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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BAIAP2L1-MET

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BAIAP2L1-MET
	FusionPDB ID: 8923
	FusionGDB2.0 ID: 8923
		Hgene	Tgene
	Gene symbol	BAIAP2L1	MET
	Gene ID	55971	8731
	Gene name	BAR/IMD domain containing adaptor protein 2 like 1	RNA guanine-7 methyltransferase
	Synonyms	IRTKS	CMT1\|CMT1c\|MET\|Met\|RG7MT1\|cm1p\|hCMT1\|hMet
	Cytomap	7q21.3-q22.1	18p11.21
	Type of gene	protein-coding	protein-coding
	Description	brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1BAI1 associated protein 2 like 1BAI1-associated protein 2-like protein 1insulin receptor tyrosine kinase substrate	mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
	Modification date	20200313	20200329
	UniProtAcc	Q9UHR4	Q9H1A3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000005260, ENST00000462558,	ENST00000436117, ENST00000495962, ENST00000539704, ENST00000318493, ENST00000397752,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 13 X 9=2340	14 X 18 X 10=2520
	# samples	23	27
	** MAII score	log2(23/2340*10)=-3.34680276352639 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/2520*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BAIAP2L1 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BAIAP2L1(97939757)-MET(116414935), # samples:2
Anticipated loss of major functional domain due to fusion event.	BAIAP2L1-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAIAP2L1-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAIAP2L1-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BAIAP2L1-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BAIAP2L1	GO:0009617	response to bacterium	19366662
Hgene	BAIAP2L1	GO:0030838	positive regulation of actin filament polymerization	21098279
Tgene	MET	GO:0006370	7-methylguanosine mRNA capping	27422871

Fusion gene breakpoints across BAIAP2L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-BQ-7049-01A	BAIAP2L1	chr7	97939757	-	MET	chr7	116414935	+
ChimerDB4	KIRP	TCGA-BQ-7049	BAIAP2L1	chr7	97939756	-	MET	chr7	116414934	+
ChimerDB4	KIRP	TCGA-BQ-7049	BAIAP2L1	chr7	97939757	-	MET	chr7	116414935	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000005260	BAIAP2L1	chr7	97939757	-	ENST00000397752	MET	chr7	116414935	+	4578	1171	33	2315	760
ENST00000005260	BAIAP2L1	chr7	97939757	-	ENST00000318493	MET	chr7	116414935	+	2534	1171	33	2315	760
ENST00000005260	BAIAP2L1	chr7	97939756	-	ENST00000397752	MET	chr7	116414934	+	4578	1171	33	2315	760
ENST00000005260	BAIAP2L1	chr7	97939756	-	ENST00000318493	MET	chr7	116414934	+	2534	1171	33	2315	760

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000005260	ENST00000397752	BAIAP2L1	chr7	97939757	-	MET	chr7	116414935	+	0.000213812	0.9997862
ENST00000005260	ENST00000318493	BAIAP2L1	chr7	97939757	-	MET	chr7	116414935	+	0.000811131	0.99918884
ENST00000005260	ENST00000397752	BAIAP2L1	chr7	97939756	-	MET	chr7	116414934	+	0.000213812	0.9997862
ENST00000005260	ENST00000318493	BAIAP2L1	chr7	97939756	-	MET	chr7	116414934	+	0.000811131	0.99918884

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8923_8923_1_BAIAP2L1-MET_BAIAP2L1_chr7_97939756_ENST00000005260_MET_chr7_116414934_ENST00000318493_length(amino acids)=760AA_BP=378
MPQVLTFSQRRRARALSGRRLRRRPTLQSPLVAPRPSRCPESGGHEAQPRPPALARPAAAAMSRGPEEVNRLTESTYRNVMEQFNPGLRN
LINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATL
KRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHY
YHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLID
MFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR
NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYV

--------------------------------------------------------------

>8923_8923_2_BAIAP2L1-MET_BAIAP2L1_chr7_97939756_ENST00000005260_MET_chr7_116414934_ENST00000397752_length(amino acids)=760AA_BP=378
MPQVLTFSQRRRARALSGRRLRRRPTLQSPLVAPRPSRCPESGGHEAQPRPPALARPAAAAMSRGPEEVNRLTESTYRNVMEQFNPGLRN
LINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATL
KRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHY
YHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLID
MFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR
NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYV

--------------------------------------------------------------

>8923_8923_3_BAIAP2L1-MET_BAIAP2L1_chr7_97939757_ENST00000005260_MET_chr7_116414935_ENST00000318493_length(amino acids)=760AA_BP=378
MPQVLTFSQRRRARALSGRRLRRRPTLQSPLVAPRPSRCPESGGHEAQPRPPALARPAAAAMSRGPEEVNRLTESTYRNVMEQFNPGLRN
LINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATL
KRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHY
YHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLID
MFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR
NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYV

--------------------------------------------------------------

>8923_8923_4_BAIAP2L1-MET_BAIAP2L1_chr7_97939757_ENST00000005260_MET_chr7_116414935_ENST00000397752_length(amino acids)=760AA_BP=378
MPQVLTFSQRRRARALSGRRLRRRPTLQSPLVAPRPSRCPESGGHEAQPRPPALARPAAAAMSRGPEEVNRLTESTYRNVMEQFNPGLRN
LINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATL
KRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHY
YHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLID
MFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR
NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:97939757/chr7:116414935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BAIAP2L1 Q9UHR4	MET Q9H1A3
FUNCTION: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269\|PubMed:17430976, ECO:0000269\|PubMed:19366662, ECO:0000269\|PubMed:22921828}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BAIAP2L1

chr7:97939756

chr7:116414934

ENST00000005260

115_154

318.3333333333333

512.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2L1

chr7:97939757

chr7:116414935

ENST00000005260

115_154

318.3333333333333

512.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2L1

chr7:97939756

chr7:116414934

ENST00000005260

1_249

318.3333333333333

512.0

Domain

IMD

Hgene

BAIAP2L1

chr7:97939757

chr7:116414935

ENST00000005260

1_249

318.3333333333333

512.0

Domain

IMD

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

1078_1345

1027.3333333333333

1409.0

Domain

Protein kinase

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

1078_1345

1009.3333333333334

1391.0

Domain

Protein kinase

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

1078_1345

0.0

765.0

Domain

Protein kinase

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

27_515

0.0

765.0

Domain

Sema

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

563_655

0.0

765.0

Domain

Note=IPT/TIG 1

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

657_739

0.0

765.0

Domain

Note=IPT/TIG 2

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

742_836

0.0

765.0

Domain

Note=IPT/TIG 3

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

1078_1345

1027.3333333333333

1409.0

Domain

Protein kinase

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

1078_1345

1009.3333333333334

1391.0

Domain

Protein kinase

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

1078_1345

0.0

765.0

Domain

Protein kinase

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

27_515

0.0

765.0

Domain

Sema

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

563_655

0.0

765.0

Domain

Note=IPT/TIG 1

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

657_739

0.0

765.0

Domain

Note=IPT/TIG 2

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

742_836

0.0

765.0

Domain

Note=IPT/TIG 3

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

1084_1092

1027.3333333333333

1409.0

Nucleotide binding

ATP

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

1084_1092

1009.3333333333334

1391.0

Nucleotide binding

ATP

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

1084_1092

0.0

765.0

Nucleotide binding

ATP

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

1084_1092

1027.3333333333333

1409.0

Nucleotide binding

ATP

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

1084_1092

1009.3333333333334

1391.0

Nucleotide binding

ATP

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

1084_1092

0.0

765.0

Nucleotide binding

ATP

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

25_932

0.0

765.0

Topological domain

Extracellular

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

956_1390

0.0

765.0

Topological domain

Cytoplasmic

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

25_932

0.0

765.0

Topological domain

Extracellular

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

956_1390

0.0

765.0

Topological domain

Cytoplasmic

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000436117

933_955

0.0

765.0

Transmembrane

Helical

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000436117

933_955

0.0

765.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BAIAP2L1

chr7:97939756

chr7:116414934

ENST00000005260

339_402

318.3333333333333

512.0

Domain

SH3

Hgene

BAIAP2L1

chr7:97939757

chr7:116414935

ENST00000005260

339_402

318.3333333333333

512.0

Domain

SH3

Hgene

BAIAP2L1

chr7:97939756

chr7:116414934

ENST00000005260

483_511

318.3333333333333

512.0

Region

Note=Binds F-actin

Hgene

BAIAP2L1

chr7:97939757

chr7:116414935

ENST00000005260

483_511

318.3333333333333

512.0

Region

Note=Binds F-actin

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

27_515

1027.3333333333333

1409.0

Domain

Sema

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

563_655

1027.3333333333333

1409.0

Domain

Note=IPT/TIG 1

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

657_739

1027.3333333333333

1409.0

Domain

Note=IPT/TIG 2

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

742_836

1027.3333333333333

1409.0

Domain

Note=IPT/TIG 3

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

27_515

1009.3333333333334

1391.0

Domain

Sema

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

563_655

1009.3333333333334

1391.0

Domain

Note=IPT/TIG 1

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

657_739

1009.3333333333334

1391.0

Domain

Note=IPT/TIG 2

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

742_836

1009.3333333333334

1391.0

Domain

Note=IPT/TIG 3

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

27_515

1027.3333333333333

1409.0

Domain

Sema

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

563_655

1027.3333333333333

1409.0

Domain

Note=IPT/TIG 1

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

657_739

1027.3333333333333

1409.0

Domain

Note=IPT/TIG 2

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

742_836

1027.3333333333333

1409.0

Domain

Note=IPT/TIG 3

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

27_515

1009.3333333333334

1391.0

Domain

Sema

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

563_655

1009.3333333333334

1391.0

Domain

Note=IPT/TIG 1

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

657_739

1009.3333333333334

1391.0

Domain

Note=IPT/TIG 2

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

742_836

1009.3333333333334

1391.0

Domain

Note=IPT/TIG 3

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

25_932

1027.3333333333333

1409.0

Topological domain

Extracellular

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

956_1390

1027.3333333333333

1409.0

Topological domain

Cytoplasmic

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

25_932

1009.3333333333334

1391.0

Topological domain

Extracellular

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

956_1390

1009.3333333333334

1391.0

Topological domain

Cytoplasmic

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

25_932

1027.3333333333333

1409.0

Topological domain

Extracellular

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

956_1390

1027.3333333333333

1409.0

Topological domain

Cytoplasmic

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

25_932

1009.3333333333334

1391.0

Topological domain

Extracellular

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

956_1390

1009.3333333333334

1391.0

Topological domain

Cytoplasmic

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000318493

933_955

1027.3333333333333

1409.0

Transmembrane

Helical

Tgene

MET

chr7:97939756

chr7:116414934

ENST00000397752

933_955

1009.3333333333334

1391.0

Transmembrane

Helical

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000318493

933_955

1027.3333333333333

1409.0

Transmembrane

Helical

Tgene

MET

chr7:97939757

chr7:116414935

ENST00000397752

933_955

1009.3333333333334

1391.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1530_BAIAP2L1_97939757_MET_116414935_ranked_0.pdb	BAIAP2L1	97939756	97939757	ENST00000318493	MET	chr7	116414935	+	MPQVLTFSQRRRARALSGRRLRRRPTLQSPLVAPRPSRCPESGGHEAQPRPPALARPAAAAMSRGPEEVNRLTESTYRNVMEQFNPGLRN LINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATL KRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHY YHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLID MFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYV	760

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

BAIAP2L1_pLDDT.png

MET_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BAIAP2L1
MET

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to BAIAP2L1-MET

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to BAIAP2L1-MET

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BAIAP2L1	C0003873	Rheumatoid Arthritis	1	CTD_human