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Fusion Protein:TNIP1-NIPAL4 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: TNIP1-NIPAL4 | FusionPDB ID: 92708 | FusionGDB2.0 ID: 92708 | Hgene | Tgene | Gene symbol | TNIP1 | NIPAL4 | Gene ID | 10318 | 348938 |
Gene name | TNFAIP3 interacting protein 1 | NIPA like domain containing 4 | |
Synonyms | ABIN-1|NAF1|VAN|nip40-1 | ARCI6|ICHTHYIN|ICHYN | |
Cytomap | 5q33.1 | 5q33.3 | |
Type of gene | protein-coding | protein-coding | |
Description | TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein | magnesium transporter NIPA4NIPA-like protein 4non-imprinted in Prader-Willi/Angelman syndrome region protein 4 | |
Modification date | 20200327 | 20200327 | |
UniProtAcc | Q15025 | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000315050, ENST00000389378, ENST00000518977, ENST00000520931, ENST00000521591, ENST00000522226, ENST00000523200, ENST00000523338, ENST00000524280, ENST00000521423, | ENST00000521390, ENST00000311946, ENST00000435489, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 11 X 10 X 7=770 | 2 X 1 X 1=2 |
# samples | 11 | 1 | |
** MAII score | log2(11/770*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: TNIP1 [Title/Abstract] AND NIPAL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TNIP1(150441688)-NIPAL4(156890102), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TNIP1-NIPAL4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TNIP1 | GO:0009101 | glycoprotein biosynthetic process | 9923610 |
Hgene | TNIP1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 16684768 |
Hgene | TNIP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12220502 |
Hgene | TNIP1 | GO:0085032 | modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade | 20010814 |
Hgene | TNIP1 | GO:1903003 | positive regulation of protein deubiquitination | 16684768 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | KIRC | TCGA-BP-4986-01A | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000520931 | TNIP1 | chr5 | 150441688 | - | ENST00000435489 | NIPAL4 | chr5 | 156890102 | + | 1619 | 358 | 363 | 1478 | 371 |
ENST00000520931 | TNIP1 | chr5 | 150441688 | - | ENST00000311946 | NIPAL4 | chr5 | 156890102 | + | 3293 | 358 | 363 | 1535 | 390 |
ENST00000389378 | TNIP1 | chr5 | 150441688 | - | ENST00000435489 | NIPAL4 | chr5 | 156890102 | + | 2207 | 946 | 951 | 2066 | 371 |
ENST00000389378 | TNIP1 | chr5 | 150441688 | - | ENST00000311946 | NIPAL4 | chr5 | 156890102 | + | 3881 | 946 | 951 | 2123 | 390 |
ENST00000523338 | TNIP1 | chr5 | 150441688 | - | ENST00000435489 | NIPAL4 | chr5 | 156890102 | + | 1728 | 467 | 472 | 1587 | 371 |
ENST00000523338 | TNIP1 | chr5 | 150441688 | - | ENST00000311946 | NIPAL4 | chr5 | 156890102 | + | 3402 | 467 | 472 | 1644 | 390 |
ENST00000315050 | TNIP1 | chr5 | 150441688 | - | ENST00000435489 | NIPAL4 | chr5 | 156890102 | + | 1728 | 467 | 472 | 1587 | 371 |
ENST00000315050 | TNIP1 | chr5 | 150441688 | - | ENST00000311946 | NIPAL4 | chr5 | 156890102 | + | 3402 | 467 | 472 | 1644 | 390 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000520931 | ENST00000435489 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.014686422 | 0.9853136 |
ENST00000520931 | ENST00000311946 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.005537761 | 0.9944622 |
ENST00000389378 | ENST00000435489 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.019336088 | 0.9806639 |
ENST00000389378 | ENST00000311946 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.005877899 | 0.9941221 |
ENST00000523338 | ENST00000435489 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.016560746 | 0.98343927 |
ENST00000523338 | ENST00000311946 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.005518195 | 0.9944818 |
ENST00000315050 | ENST00000435489 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.016560746 | 0.98343927 |
ENST00000315050 | ENST00000311946 | TNIP1 | chr5 | 150441688 | - | NIPAL4 | chr5 | 156890102 | + | 0.005518195 | 0.9944818 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >92708_92708_1_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR -------------------------------------------------------------- >92708_92708_2_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP -------------------------------------------------------------- >92708_92708_3_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR -------------------------------------------------------------- >92708_92708_4_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP -------------------------------------------------------------- >92708_92708_5_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR -------------------------------------------------------------- >92708_92708_6_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP -------------------------------------------------------------- >92708_92708_7_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR -------------------------------------------------------------- >92708_92708_8_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1 MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:150441688/chr5:156890102) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
TNIP1 | . |
FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 20_73 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 20_73 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 20_73 | 119.0 | 636.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 20_73 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 20_73 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 20_73 | 119.0 | 636.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 139_164 | 74.33333333333333 | 467.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 186_186 | 74.33333333333333 | 467.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 208_215 | 74.33333333333333 | 467.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 237_257 | 74.33333333333333 | 467.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 279_285 | 74.33333333333333 | 467.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 307_323 | 74.33333333333333 | 467.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 345_355 | 74.33333333333333 | 467.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 377_386 | 74.33333333333333 | 467.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 408_466 | 74.33333333333333 | 467.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 139_164 | 74.33333333333333 | 448.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 186_186 | 74.33333333333333 | 448.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 208_215 | 74.33333333333333 | 448.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 237_257 | 74.33333333333333 | 448.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 279_285 | 74.33333333333333 | 448.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 307_323 | 74.33333333333333 | 448.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 345_355 | 74.33333333333333 | 448.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 377_386 | 74.33333333333333 | 448.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 408_466 | 74.33333333333333 | 448.0 | Topological domain | Cytoplasmic | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 118_138 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 165_185 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 187_207 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 216_236 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 258_278 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 286_306 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 324_344 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 356_376 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 387_407 | 74.33333333333333 | 467.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 118_138 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 165_185 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 187_207 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 216_236 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 258_278 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 286_306 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 324_344 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 356_376 | 74.33333333333333 | 448.0 | Transmembrane | Helical | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 387_407 | 74.33333333333333 | 448.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 196_258 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 294_535 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 196_258 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 294_535 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 196_258 | 119.0 | 636.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 294_535 | 119.0 | 636.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 196_258 | 66.0 | 584.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 20_73 | 66.0 | 584.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 294_535 | 66.0 | 584.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 196_258 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 294_535 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 196_258 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 294_535 | 119.0 | 637.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 196_258 | 119.0 | 636.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 294_535 | 119.0 | 636.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 539_636 | 119.0 | 637.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 539_636 | 119.0 | 637.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 539_636 | 119.0 | 636.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 539_636 | 66.0 | 584.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 539_636 | 119.0 | 637.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 539_636 | 119.0 | 637.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 539_636 | 119.0 | 636.0 | Compositional bias | Note=Pro-rich |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 524_530 | 119.0 | 637.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 524_530 | 119.0 | 637.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 524_530 | 119.0 | 636.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 524_530 | 66.0 | 584.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 524_530 | 119.0 | 637.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 524_530 | 119.0 | 637.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 524_530 | 119.0 | 636.0 | Motif | Nuclear localization signal |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 431_588 | 119.0 | 637.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 452_510 | 119.0 | 637.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 431_588 | 119.0 | 637.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 452_510 | 119.0 | 637.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 431_588 | 119.0 | 636.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 452_510 | 119.0 | 636.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 431_588 | 66.0 | 584.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 452_510 | 66.0 | 584.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 431_588 | 119.0 | 637.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 452_510 | 119.0 | 637.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 431_588 | 119.0 | 637.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 452_510 | 119.0 | 637.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 431_588 | 119.0 | 636.0 | Region | Required for inhibitory activity of TNF-induced NF-kappa-B activation |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 452_510 | 119.0 | 636.0 | Region | Note=Ubiquitin-binding domain (UBD) |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000311946 | 0 | 6 | 1_117 | 74.33333333333333 | 467.0 | Topological domain | Extracellular | |
Tgene | NIPAL4 | chr5:150441688 | chr5:156890102 | ENST00000435489 | 0 | 5 | 1_117 | 74.33333333333333 | 448.0 | Topological domain | Extracellular |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
TNIP1 | |
NIPAL4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 94_412 | 119.0 | 637.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 94_412 | 119.0 | 637.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 94_412 | 119.0 | 636.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 94_412 | 66.0 | 584.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 94_412 | 119.0 | 637.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 94_412 | 119.0 | 637.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 94_412 | 119.0 | 636.0 | Nef |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000315050 | - | 4 | 18 | 351_367 | 119.0 | 637.0 | Shigella flexneri ipah9.8 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000389378 | - | 4 | 18 | 351_367 | 119.0 | 637.0 | Shigella flexneri ipah9.8 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000518977 | - | 4 | 18 | 351_367 | 119.0 | 636.0 | Shigella flexneri ipah9.8 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000520931 | - | 3 | 17 | 351_367 | 66.0 | 584.0 | Shigella flexneri ipah9.8 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000521591 | - | 4 | 18 | 351_367 | 119.0 | 637.0 | Shigella flexneri ipah9.8 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000522226 | - | 4 | 18 | 351_367 | 119.0 | 637.0 | Shigella flexneri ipah9.8 |
Hgene | TNIP1 | chr5:150441688 | chr5:156890102 | ENST00000523338 | - | 4 | 18 | 351_367 | 119.0 | 636.0 | Shigella flexneri ipah9.8 |
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Related Drugs to TNIP1-NIPAL4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TNIP1-NIPAL4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |