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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TNIP1-NIPAL4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TNIP1-NIPAL4
FusionPDB ID: 92708
FusionGDB2.0 ID: 92708
HgeneTgene
Gene symbol

TNIP1

NIPAL4

Gene ID

10318

348938

Gene nameTNFAIP3 interacting protein 1NIPA like domain containing 4
SynonymsABIN-1|NAF1|VAN|nip40-1ARCI6|ICHTHYIN|ICHYN
Cytomap

5q33.1

5q33.3

Type of geneprotein-codingprotein-coding
DescriptionTNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling proteinmagnesium transporter NIPA4NIPA-like protein 4non-imprinted in Prader-Willi/Angelman syndrome region protein 4
Modification date2020032720200327
UniProtAcc

Q15025

.
Ensembl transtripts involved in fusion geneENST idsENST00000315050, ENST00000389378, 
ENST00000518977, ENST00000520931, 
ENST00000521591, ENST00000522226, 
ENST00000523200, ENST00000523338, 
ENST00000524280, ENST00000521423, 
ENST00000521390, ENST00000311946, 
ENST00000435489, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 10 X 7=7702 X 1 X 1=2
# samples 111
** MAII scorelog2(11/770*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: TNIP1 [Title/Abstract] AND NIPAL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TNIP1(150441688)-NIPAL4(156890102), # samples:2
Anticipated loss of major functional domain due to fusion event.TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNIP1-NIPAL4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIP1

GO:0009101

glycoprotein biosynthetic process

9923610

HgeneTNIP1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

16684768

HgeneTNIP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

12220502

HgeneTNIP1

GO:0085032

modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

20010814

HgeneTNIP1

GO:1903003

positive regulation of protein deubiquitination

16684768


check buttonFusion gene breakpoints across TNIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NIPAL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4986-01ATNIP1chr5

150441688

-NIPAL4chr5

156890102

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000520931TNIP1chr5150441688-ENST00000435489NIPAL4chr5156890102+16193583631478371
ENST00000520931TNIP1chr5150441688-ENST00000311946NIPAL4chr5156890102+32933583631535390
ENST00000389378TNIP1chr5150441688-ENST00000435489NIPAL4chr5156890102+22079469512066371
ENST00000389378TNIP1chr5150441688-ENST00000311946NIPAL4chr5156890102+38819469512123390
ENST00000523338TNIP1chr5150441688-ENST00000435489NIPAL4chr5156890102+17284674721587371
ENST00000523338TNIP1chr5150441688-ENST00000311946NIPAL4chr5156890102+34024674721644390
ENST00000315050TNIP1chr5150441688-ENST00000435489NIPAL4chr5156890102+17284674721587371
ENST00000315050TNIP1chr5150441688-ENST00000311946NIPAL4chr5156890102+34024674721644390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520931ENST00000435489TNIP1chr5150441688-NIPAL4chr5156890102+0.0146864220.9853136
ENST00000520931ENST00000311946TNIP1chr5150441688-NIPAL4chr5156890102+0.0055377610.9944622
ENST00000389378ENST00000435489TNIP1chr5150441688-NIPAL4chr5156890102+0.0193360880.9806639
ENST00000389378ENST00000311946TNIP1chr5150441688-NIPAL4chr5156890102+0.0058778990.9941221
ENST00000523338ENST00000435489TNIP1chr5150441688-NIPAL4chr5156890102+0.0165607460.98343927
ENST00000523338ENST00000311946TNIP1chr5150441688-NIPAL4chr5156890102+0.0055181950.9944818
ENST00000315050ENST00000435489TNIP1chr5150441688-NIPAL4chr5156890102+0.0165607460.98343927
ENST00000315050ENST00000311946TNIP1chr5150441688-NIPAL4chr5156890102+0.0055181950.9944818

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92708_92708_1_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------

>92708_92708_2_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------

>92708_92708_3_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------

>92708_92708_4_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------

>92708_92708_5_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------

>92708_92708_6_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------

>92708_92708_7_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------

>92708_92708_8_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:150441688/chr5:156890102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNIP1

Q15025

.
FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-41820_73119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-41820_73119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-41820_73119.0636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-41820_73119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-41820_73119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-41820_73119.0636.0Coiled coilOntology_term=ECO:0000255
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606139_16474.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606186_18674.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606208_21574.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606237_25774.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606279_28574.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606307_32374.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606345_35574.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606377_38674.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606408_46674.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905139_16474.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905186_18674.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905208_21574.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905237_25774.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905279_28574.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905307_32374.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905345_35574.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905377_38674.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905408_46674.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606118_13874.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606165_18574.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606187_20774.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606216_23674.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606258_27874.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606286_30674.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606324_34474.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606356_37674.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000031194606387_40774.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905118_13874.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905165_18574.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905187_20774.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905216_23674.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905258_27874.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905286_30674.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905324_34474.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905356_37674.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:150441688chr5:156890102ENST0000043548905387_40774.33333333333333448.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418196_258119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418294_535119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418196_258119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418294_535119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418196_258119.0636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418294_535119.0636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317196_25866.0584.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-31720_7366.0584.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317294_53566.0584.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418196_258119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418294_535119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418196_258119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418294_535119.0637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418196_258119.0636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418294_535119.0636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418539_636119.0637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418539_636119.0637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418539_636119.0636.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317539_63666.0584.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418539_636119.0637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418539_636119.0637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418539_636119.0636.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418524_530119.0637.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418524_530119.0637.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418524_530119.0636.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317524_53066.0584.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418524_530119.0637.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418524_530119.0637.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418524_530119.0636.0MotifNuclear localization signal
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418431_588119.0637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418452_510119.0637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418431_588119.0637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418452_510119.0637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418431_588119.0636.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418452_510119.0636.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317431_58866.0584.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317452_51066.0584.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418431_588119.0637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418452_510119.0637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418431_588119.0637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418452_510119.0637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418431_588119.0636.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418452_510119.0636.0RegionNote=Ubiquitin-binding domain (UBD)
TgeneNIPAL4chr5:150441688chr5:156890102ENST00000311946061_11774.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:150441688chr5:156890102ENST00000435489051_11774.33333333333333448.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TNIP1
NIPAL4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-41894_412119.0637.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-41894_412119.0637.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-41894_412119.0636.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-31794_41266.0584.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-41894_412119.0637.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-41894_412119.0637.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-41894_412119.0636.0Nef
HgeneTNIP1chr5:150441688chr5:156890102ENST00000315050-418351_367119.0637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150441688chr5:156890102ENST00000389378-418351_367119.0637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150441688chr5:156890102ENST00000518977-418351_367119.0636.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150441688chr5:156890102ENST00000520931-317351_36766.0584.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150441688chr5:156890102ENST00000521591-418351_367119.0637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150441688chr5:156890102ENST00000522226-418351_367119.0637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150441688chr5:156890102ENST00000523338-418351_367119.0636.0Shigella flexneri ipah9.8


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Related Drugs to TNIP1-NIPAL4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TNIP1-NIPAL4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource