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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TNPO2-DNASE2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TNPO2-DNASE2
FusionPDB ID: 92795
FusionGDB2.0 ID: 92795
HgeneTgene
Gene symbol

TNPO2

DNASE2

Gene ID

30000

1777

Gene nametransportin 2deoxyribonuclease 2, lysosomal
SynonymsIPO3|KPNB2B|TRN2DNASE2A|DNL|DNL2
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
Descriptiontransportin-2importin 3karyopherin beta 2b, transportinkaryopherin beta-2btransportin 2 (importin 3, karyopherin beta 2b)deoxyribonuclease-2-alphaDNase II alphaDNase II, lysosomalR31240_2acid DNasedeoxyribonuclease II alphadeoxyribonuclease II, lysosomallysosomal DNase II
Modification date2020031320200313
UniProtAcc.

O00115

Ensembl transtripts involved in fusion geneENST idsENST00000356861, ENST00000425528, 
ENST00000441499, ENST00000450764, 
ENST00000588216, ENST00000592287, 
ENST00000589956, 		ENST00000222219, 
ENST00000538460, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 19 X 8=28883 X 3 X 3=27
# samples 244
** MAII scorelog2(24/2888*10)=-3.58896443127865
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TNPO2 [Title/Abstract] AND DNASE2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TNPO2(12816054)-DNASE2(12987177), # samples:3
Anticipated loss of major functional domain due to fusion event.TNPO2-DNASE2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNPO2-DNASE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TNPO2-DNASE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNPO2-DNASE2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNPO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNASE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-43-5670-01ATNPO2chr19

12816054

-DNASE2chr19

12987177

-
ChimerDB4LUSCTCGA-43-5670TNPO2chr19

12816053

-DNASE2chr19

12987177

-
ChimerDB4LUSCTCGA-43-5670TNPO2chr19

12816054

-DNASE2chr19

12987177

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425528TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000441499TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000356861TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-267622571992328709
ENST00000450764TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-317927603422831829
ENST00000592287TNPO2chr1912816054-ENST00000222219DNASE2chr1912987177-32842131492202717
ENST00000588216TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-281423953312466711
ENST00000425528TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000441499TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000356861TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-267622571992328709
ENST00000450764TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-317927603422831829
ENST00000592287TNPO2chr1912816053-ENST00000222219DNASE2chr1912987177-32842131492202717
ENST00000588216TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-281423953312466711

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425528ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0105365460.98946345
ENST00000441499ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0105365460.98946345
ENST00000356861ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0091519550.99084806
ENST00000450764ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0150405310.9849594
ENST00000592287ENST00000222219TNPO2chr1912816054-DNASE2chr1912987177-0.0111233980.98887664
ENST00000588216ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0108741050.98912597
ENST00000425528ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0105365460.98946345
ENST00000441499ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0105365460.98946345
ENST00000356861ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0091519550.99084806
ENST00000450764ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0150405310.9849594
ENST00000592287ENST00000222219TNPO2chr1912816053-DNASE2chr1912987177-0.0111233980.98887664
ENST00000588216ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0108741050.98912597

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92795_92795_1_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000356861_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=709AA_BP=685
MGDVARIGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHY
QSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNR
PLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQY
MLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHE
AERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIP
HLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFG
KYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA

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>92795_92795_2_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000425528_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

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>92795_92795_3_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000441499_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

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>92795_92795_4_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000450764_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=829AA_BP=805
MDVEAAGPSPSRCEGGGSLRARSRGQRHGPPWDEGSSLGPMRIRRAPPPPPVARFHIPPPALPSPRLRGRGWRSWRGPRTWAGVDRRPPP
VRRGRSRRHAATAASGAPPGSHTEPQRPSADPGPYLRSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYL
IFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSE
DYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPE
VRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKG
DVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEW
VVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAAC
SAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLS
SVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQTCTP

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>92795_92795_5_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000588216_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

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>92795_92795_6_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000592287_DNASE2_chr19_12987177_ENST00000222219_length(amino acids)=717AA_BP=693
MEKPQRELPPLLPGAGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLIL
KNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSEL
LDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIP
HMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKS
RTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMV
PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYIL
DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCV

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>92795_92795_7_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000356861_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=709AA_BP=685
MGDVARIGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHY
QSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNR
PLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQY
MLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHE
AERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIP
HLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFG
KYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA

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>92795_92795_8_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000425528_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

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>92795_92795_9_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000441499_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

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>92795_92795_10_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000450764_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=829AA_BP=805
MDVEAAGPSPSRCEGGGSLRARSRGQRHGPPWDEGSSLGPMRIRRAPPPPPVARFHIPPPALPSPRLRGRGWRSWRGPRTWAGVDRRPPP
VRRGRSRRHAATAASGAPPGSHTEPQRPSADPGPYLRSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYL
IFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSE
DYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPE
VRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKG
DVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEW
VVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAAC
SAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLS
SVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQTCTP

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>92795_92795_11_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000588216_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

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>92795_92795_12_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000592287_DNASE2_chr19_12987177_ENST00000222219_length(amino acids)=717AA_BP=693
MEKPQRELPPLLPGAGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLIL
KNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSEL
LDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIP
HMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKS
RTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMV
PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYIL
DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12816054/chr19:12987177)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNASE2

O00115

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-172531_99674.01500.3333333333333DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-182631_99674.01509.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-182631_99674.01499.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-162431_99674.01150.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-182531_99674.0888.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-172531_99674.0901.6666666666666DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-172531_99674.01500.3333333333333DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-182631_99674.01509.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-182631_99674.01499.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-162431_99674.01150.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-182531_99674.0888.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-172531_99674.0901.6666666666666DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725127_164674.01500.3333333333333RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725171_201674.01500.3333333333333RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725214_241674.01500.3333333333333RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725253_280674.01500.3333333333333RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725296_386674.01500.3333333333333RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725394_422674.01500.3333333333333RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-172541_79674.01500.3333333333333RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725434_461674.01500.3333333333333RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725475_508674.01500.3333333333333RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725516_549674.01500.3333333333333RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725557_595674.01500.3333333333333RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725603_654674.01500.3333333333333RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-172588_121674.01500.3333333333333RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-17259_36674.01500.3333333333333RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826127_164674.01509.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826171_201674.01509.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826214_241674.01509.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826253_280674.01509.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826296_386674.01509.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826394_422674.01509.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-182641_79674.01509.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826434_461674.01509.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826475_508674.01509.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826516_549674.01509.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826557_595674.01509.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826603_654674.01509.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-182688_121674.01509.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-18269_36674.01509.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826127_164674.01499.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826171_201674.01499.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826214_241674.01499.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826253_280674.01499.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826296_386674.01499.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826394_422674.01499.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-182641_79674.01499.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826434_461674.01499.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826475_508674.01499.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826516_549674.01499.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826557_595674.01499.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826603_654674.01499.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-182688_121674.01499.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-18269_36674.01499.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624127_164674.01150.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624171_201674.01150.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624214_241674.01150.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624253_280674.01150.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624296_386674.01150.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624394_422674.01150.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-162441_79674.01150.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624434_461674.01150.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624475_508674.01150.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624516_549674.01150.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624557_595674.01150.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624603_654674.01150.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-162488_121674.01150.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-16249_36674.01150.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825127_164674.0888.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825171_201674.0888.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825214_241674.0888.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825253_280674.0888.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825296_386674.0888.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825394_422674.0888.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-182541_79674.0888.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825434_461674.0888.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825475_508674.0888.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825516_549674.0888.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825557_595674.0888.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825603_654674.0888.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-182588_121674.0888.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-18259_36674.0888.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725127_164674.0901.6666666666666RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725171_201674.0901.6666666666666RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725214_241674.0901.6666666666666RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725253_280674.0901.6666666666666RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725296_386674.0901.6666666666666RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725394_422674.0901.6666666666666RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-172541_79674.0901.6666666666666RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725434_461674.0901.6666666666666RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725475_508674.0901.6666666666666RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725516_549674.0901.6666666666666RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725557_595674.0901.6666666666666RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725603_654674.0901.6666666666666RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-172588_121674.0901.6666666666666RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-17259_36674.0901.6666666666666RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725127_164674.01500.3333333333333RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725171_201674.01500.3333333333333RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725214_241674.01500.3333333333333RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725253_280674.01500.3333333333333RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725296_386674.01500.3333333333333RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725394_422674.01500.3333333333333RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-172541_79674.01500.3333333333333RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725434_461674.01500.3333333333333RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725475_508674.01500.3333333333333RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725516_549674.01500.3333333333333RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725557_595674.01500.3333333333333RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725603_654674.01500.3333333333333RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-172588_121674.01500.3333333333333RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-17259_36674.01500.3333333333333RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826127_164674.01509.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826171_201674.01509.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826214_241674.01509.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826253_280674.01509.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826296_386674.01509.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826394_422674.01509.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-182641_79674.01509.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826434_461674.01509.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826475_508674.01509.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826516_549674.01509.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826557_595674.01509.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826603_654674.01509.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-182688_121674.01509.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-18269_36674.01509.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826127_164674.01499.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826171_201674.01499.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826214_241674.01499.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826253_280674.01499.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826296_386674.01499.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826394_422674.01499.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-182641_79674.01499.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826434_461674.01499.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826475_508674.01499.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826516_549674.01499.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826557_595674.01499.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826603_654674.01499.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-182688_121674.01499.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-18269_36674.01499.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624127_164674.01150.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624171_201674.01150.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624214_241674.01150.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624253_280674.01150.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624296_386674.01150.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624394_422674.01150.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-162441_79674.01150.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624434_461674.01150.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624475_508674.01150.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624516_549674.01150.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624557_595674.01150.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624603_654674.01150.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-162488_121674.01150.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-16249_36674.01150.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825127_164674.0888.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825171_201674.0888.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825214_241674.0888.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825253_280674.0888.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825296_386674.0888.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825394_422674.0888.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-182541_79674.0888.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825434_461674.0888.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825475_508674.0888.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825516_549674.0888.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825557_595674.0888.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825603_654674.0888.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-182588_121674.0888.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-18259_36674.0888.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725127_164674.0901.6666666666666RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725171_201674.0901.6666666666666RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725214_241674.0901.6666666666666RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725253_280674.0901.6666666666666RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725296_386674.0901.6666666666666RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725394_422674.0901.6666666666666RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-172541_79674.0901.6666666666666RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725434_461674.0901.6666666666666RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725475_508674.0901.6666666666666RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725516_549674.0901.6666666666666RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725557_595674.0901.6666666666666RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725603_654674.0901.6666666666666RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-172588_121674.0901.6666666666666RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-17259_36674.0901.6666666666666RepeatHEAT 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725665_696674.01500.3333333333333RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725704_737674.01500.3333333333333RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725745_790674.01500.3333333333333RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725798_831674.01500.3333333333333RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725840_871674.01500.3333333333333RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725874_894674.01500.3333333333333RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826665_696674.01509.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826704_737674.01509.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826745_790674.01509.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826798_831674.01509.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826840_871674.01509.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826874_894674.01509.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826665_696674.01499.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826704_737674.01499.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826745_790674.01499.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826798_831674.01499.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826840_871674.01499.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826874_894674.01499.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624665_696674.01150.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624704_737674.01150.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624745_790674.01150.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624798_831674.01150.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624840_871674.01150.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624874_894674.01150.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825665_696674.0888.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825704_737674.0888.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825745_790674.0888.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825798_831674.0888.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825840_871674.0888.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825874_894674.0888.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725665_696674.0901.6666666666666RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725704_737674.0901.6666666666666RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725745_790674.0901.6666666666666RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725798_831674.0901.6666666666666RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725840_871674.0901.6666666666666RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725874_894674.0901.6666666666666RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725665_696674.01500.3333333333333RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725704_737674.01500.3333333333333RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725745_790674.01500.3333333333333RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725798_831674.01500.3333333333333RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725840_871674.01500.3333333333333RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725874_894674.01500.3333333333333RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826665_696674.01509.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826704_737674.01509.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826745_790674.01509.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826798_831674.01509.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826840_871674.01509.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826874_894674.01509.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826665_696674.01499.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826704_737674.01499.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826745_790674.01499.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826798_831674.01499.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826840_871674.01499.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826874_894674.01499.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624665_696674.01150.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624704_737674.01150.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624745_790674.01150.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624798_831674.01150.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624840_871674.01150.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624874_894674.01150.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825665_696674.0888.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825704_737674.0888.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825745_790674.0888.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825798_831674.0888.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825840_871674.0888.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825874_894674.0888.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725665_696674.0901.6666666666666RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725704_737674.0901.6666666666666RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725745_790674.0901.6666666666666RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725798_831674.0901.6666666666666RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725840_871674.0901.6666666666666RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725874_894674.0901.6666666666666RepeatHEAT 20


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1613_TNPO2_12816054_DNASE2_12987177_ranked_0.pdbTNPO21281605312816054ENST00000538460DNASE2chr1912987177-
MDVEAAGPSPSRCEGGGSLRARSRGQRHGPPWDEGSSLGPMRIRRAPPPPPVARFHIPPPALPSPRLRGRGWRSWRGPRTWAGVDRRPPP
VRRGRSRRHAATAASGAPPGSHTEPQRPSADPGPYLRSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYL
IFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSE
DYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPE
VRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKG
DVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEW
VVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAAC
SAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLS
SVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQTCTP
829


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TNPO2_pLDDT.png
all structure
all structure
DNASE2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TNPO2
DNASE2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TNPO2-DNASE2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TNPO2-DNASE2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource