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Fusion Protein:TPM4-RPL18A |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: TPM4-RPL18A | FusionPDB ID: 93413 | FusionGDB2.0 ID: 93413 | Hgene | Tgene | Gene symbol | TPM4 | RPL18A | Gene ID | 7171 | 6142 |
Gene name | tropomyosin 4 | ribosomal protein L18a | |
Synonyms | HEL-S-108 | L18A | |
Cytomap | 19p13.12-p13.11 | 19p13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | tropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 108 | 60S ribosomal protein L18alarge ribosomal subunit protein eL20ribosomal protein L18a-like protein | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | P67936 | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000300933, ENST00000344824, ENST00000538887, ENST00000591645, | ENST00000599870, ENST00000222247, ENST00000599898, ENST00000600147, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 22 X 19 X 9=3762 | 5 X 6 X 4=120 |
# samples | 25 | 6 | |
** MAII score | log2(25/3762*10)=-3.91149984886111 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: TPM4 [Title/Abstract] AND RPL18A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TPM4(16199930)-RPL18A(17972102), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RPL18A | GO:0002181 | cytoplasmic translation | 25957688 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-20-0991-01A | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000344824 | TPM4 | chr19 | 16199930 | + | ENST00000222247 | RPL18A | chr19 | 17972102 | + | 1323 | 757 | 58 | 1269 | 403 |
ENST00000344824 | TPM4 | chr19 | 16199930 | + | ENST00000600147 | RPL18A | chr19 | 17972102 | + | 2094 | 757 | 58 | 1203 | 381 |
ENST00000344824 | TPM4 | chr19 | 16199930 | + | ENST00000599898 | RPL18A | chr19 | 17972102 | + | 1205 | 757 | 58 | 1152 | 364 |
ENST00000538887 | TPM4 | chr19 | 16199930 | + | ENST00000222247 | RPL18A | chr19 | 17972102 | + | 1292 | 726 | 27 | 1238 | 403 |
ENST00000538887 | TPM4 | chr19 | 16199930 | + | ENST00000600147 | RPL18A | chr19 | 17972102 | + | 2063 | 726 | 27 | 1172 | 381 |
ENST00000538887 | TPM4 | chr19 | 16199930 | + | ENST00000599898 | RPL18A | chr19 | 17972102 | + | 1174 | 726 | 27 | 1121 | 364 |
ENST00000300933 | TPM4 | chr19 | 16199930 | + | ENST00000222247 | RPL18A | chr19 | 17972102 | + | 1357 | 791 | 29 | 1303 | 424 |
ENST00000300933 | TPM4 | chr19 | 16199930 | + | ENST00000600147 | RPL18A | chr19 | 17972102 | + | 2128 | 791 | 29 | 1237 | 402 |
ENST00000300933 | TPM4 | chr19 | 16199930 | + | ENST00000599898 | RPL18A | chr19 | 17972102 | + | 1239 | 791 | 29 | 1186 | 385 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000344824 | ENST00000222247 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.007489086 | 0.9925109 |
ENST00000344824 | ENST00000600147 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.006676917 | 0.993323 |
ENST00000344824 | ENST00000599898 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.003973842 | 0.99602616 |
ENST00000538887 | ENST00000222247 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.008116594 | 0.9918834 |
ENST00000538887 | ENST00000600147 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.006398444 | 0.9936015 |
ENST00000538887 | ENST00000599898 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.004304338 | 0.9956956 |
ENST00000300933 | ENST00000222247 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.007399224 | 0.99260074 |
ENST00000300933 | ENST00000600147 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.006494383 | 0.9935056 |
ENST00000300933 | ENST00000599898 | TPM4 | chr19 | 16199930 | + | RPL18A | chr19 | 17972102 | + | 0.003982422 | 0.9960175 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >93413_93413_1_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000222247_length(amino acids)=424AA_BP=1 MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKC HTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRD -------------------------------------------------------------- >93413_93413_2_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000599898_length(amino acids)=385AA_BP=1 MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKLKKMKKSSGEI VYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIK -------------------------------------------------------------- >93413_93413_3_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000600147_length(amino acids)=402AA_BP=1 MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKC HTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRD -------------------------------------------------------------- >93413_93413_4_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000222247_length(amino acids)=403AA_BP=1 MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA -------------------------------------------------------------- >93413_93413_5_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000599898_length(amino acids)=364AA_BP=1 MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWL RYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRP -------------------------------------------------------------- >93413_93413_6_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000600147_length(amino acids)=381AA_BP=1 MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA -------------------------------------------------------------- >93413_93413_7_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000222247_length(amino acids)=403AA_BP=1 MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA -------------------------------------------------------------- >93413_93413_8_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000599898_length(amino acids)=364AA_BP=1 MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWL RYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRP -------------------------------------------------------------- >93413_93413_9_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000600147_length(amino acids)=381AA_BP=1 MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16199930/chr19:17972102) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
TPM4 | . |
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TPM4 | chr19:16199930 | chr19:17972102 | ENST00000300933 | + | 5 | 8 | 2_248 | 177.0 | 249.0 | Coiled coil | Ontology_term=ECO:0000250 |
Hgene | TPM4 | chr19:16199930 | chr19:17972102 | ENST00000344824 | + | 6 | 9 | 2_248 | 213.0 | 285.0 | Coiled coil | Ontology_term=ECO:0000250 |
Hgene | TPM4 | chr19:16199930 | chr19:17972102 | ENST00000538887 | + | 6 | 10 | 2_248 | 213.0 | 270.0 | Coiled coil | Ontology_term=ECO:0000250 |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
TPM4 | TCERG1, TRIP6, PACSIN1, ARRB1, SP1, CDK2, AKT1, TPM3, TPM2, TPM1, SRXN1, HNRNPK, DBN1, ZYX, PCMT1, G3BP1, PSMD2, PSMA6, CDH2, SULT1A1, SERPINH1, ILF3, ILF2, TELO2, MYH9, PSMD1, SNRNP70, TXN2, SRSF2, PRKCDBP, CORO1C, TPM3P4, DCTN2, PSMC2, ATF2, PAN2, HDAC8, PARK2, CAP1, FASN, KIAA1598, SIRT1, TP53, LNX1, PYCARD, EGFR, ACTN1, ACTN2, COX5A, OSTF1, ACTN4, ATP1A1, ATP5F1, CENPE, CKB, COX4I1, MYH7B, NDUFB10, PSMA1, TBCD, NTRK1, ADD1, CAPZA2, FLNA, PPP1CB, PPP1CC, IQGAP1, SLC33A1, PDLIM7, MAPRE1, ANLN, MYO19, MYO18A, CFAP97, Actb, Mapre1, Flot1, Myh9, Myo1c, Rab5c, Tpm1, Dctn3, Uso1, Anapc13, Calml3, 2510003E04Rik, Myh10, Tbck, Mast3, MCM2, SMURF1, ZNF131, DLST, UBE2A, CFTR, TMPO, PTPLA, PPP6C, PPM1D, PTP4A3, PTPN2, CDC25C, PTPRCAP, DUSP7, PPTC7, DUSP19, PPM1M, ILKAP, DUSP21, PHPT1, DUSP12, PPP1R3C, EFTUD2, PIH1D1, TNF, NOD2, RNF181, RNF144A, CDK9, RAB9A, HK1, METTL14, WTAP, ATG16L1, ESR2, DISC1, USP14, APEX1, DYRK1A, SCARB2, VMP1, AKT3, ATF3, PICK1, SNAPIN, JRK, CUL7, PLEKHA4, SRC, UNK, CIT, AURKB, CHMP4C, ECT2, KIF20A, PRNP, MFN2, OPA1, HNRNPH1, nsp13ab, NPC1, UCHL1, COPS5, DANCR, RIN3, TRIM24, BAG5, AR, ISG15, TMOD1, TRIM37, NAA40, MRPL50, LANCL2, ALAD, BTF3, TRIM26, EP300, CTSB, CTSS, DPP4, E, ORF8, TMPRSS2, TOP3B, CTSL, FURIN, IFITM1, IFITM3, CLEC4D, CLEC4E, nsp4, nsp6, nsp8, ORF10, S, FGD5, CCNF, PDE4B, FOS, ELK3, GATA4, IRF8, KLF10, KLF12, KLF3, KLF6, VSX1, ZIC3, MYC, NKX2-5, SOX5, STAT5B, TEAD1, TLX1, |
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Gene | STRING network |
TPM4 | ![]() |
RPL18A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to TPM4-RPL18A |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TPM4-RPL18A |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TPM4 | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human |
Hgene | TPM4 | C0003949 | Asbestosis | 1 | CTD_human |
Hgene | TPM4 | C0005818 | Blood Platelet Disorders | 1 | GENOMICS_ENGLAND |
Hgene | TPM4 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | TPM4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | TPM4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | TPM4 | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | TPM4 | C0029459 | Osteoporosis, Senile | 1 | CTD_human |
Hgene | TPM4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | TPM4 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | TPM4 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
Hgene | TPM4 | C0334121 | Inflammatory Myofibroblastic Tumor | 1 | ORPHANET |
Hgene | TPM4 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Hgene | TPM4 | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human |
Hgene | TPM4 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | TPM4 | C2751260 | Macrothrombocytopenia | 1 | GENOMICS_ENGLAND |
Hgene | TPM4 | C2930617 | Pulmonary Fibrosis - from Asbestos Exposure | 1 | CTD_human |
Hgene | TPM4 | C4304021 | Autosomal dominant macrothrombocytopenia | 1 | ORPHANET |