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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRA2A-AQP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRA2A-AQP1
FusionPDB ID: 93572
FusionGDB2.0 ID: 93572
HgeneTgene
Gene symbol

TRA2A

AQP1

Gene ID

29896

84182

Gene nametransformer 2 alpha homologMINDY lysine 48 deubiquitinase 4
SynonymsAWMS1|HSU53209AQP-1|AQP1|C7orf67|CHIP28|FAM188B
Cytomap

7p15.3

7p14.3

Type of geneprotein-codingprotein-coding
Descriptiontransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog Aprobable ubiquitin carboxyl-terminal hydrolase MINDY-4Aquaporin-1Aquaporin-CHIPMINDY deubiquitinase 4Urine water channelWater channel protein for red blood cells and kidney proximal tubulefamily with sequence similarity 188 member Bprobable deubiqu
Modification date2020031320200313
UniProtAcc.

Q8NBQ7

Ensembl transtripts involved in fusion geneENST idsENST00000297071, ENST00000392502, 
ENST00000538367, ENST00000474586, 
ENST00000409611, ENST00000409899, 
ENST00000441328, ENST00000482461, 
ENST00000311813, ENST00000434909, 
ENST00000509504, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 14 X 9=25205 X 7 X 3=105
# samples 246
** MAII scorelog2(24/2520*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRA2A [Title/Abstract] AND AQP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRA2A(23571408)-AQP1(30961681), # samples:3
Anticipated loss of major functional domain due to fusion event.TRA2A-AQP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRA2A-AQP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRA2A-AQP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRA2A-AQP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399


check buttonFusion gene breakpoints across TRA2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AQP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EK-A2PM-01ATRA2Achr7

23571407

-AQP1chr7

30961680

+
ChimerDB4CESCTCGA-EK-A2PM-01ATRA2Achr7

23571408

-AQP1chr7

30961681

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297071TRA2Achr723571408-ENST00000434909AQP1chr730961681+862253217678153
ENST00000297071TRA2Achr723571408-ENST00000509504AQP1chr730961681+862253217678153
ENST00000297071TRA2Achr723571408-ENST00000311813AQP1chr730961681+2566253217678153
ENST00000297071TRA2Achr723571407-ENST00000434909AQP1chr730961680+862253217678153
ENST00000297071TRA2Achr723571407-ENST00000509504AQP1chr730961680+862253217678153
ENST00000297071TRA2Achr723571407-ENST00000311813AQP1chr730961680+2566253217678153

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297071ENST00000434909TRA2Achr723571408-AQP1chr730961681+0.0073475020.9926524
ENST00000297071ENST00000509504TRA2Achr723571408-AQP1chr730961681+0.0073475020.9926524
ENST00000297071ENST00000311813TRA2Achr723571408-AQP1chr730961681+0.0137676220.9862324
ENST00000297071ENST00000434909TRA2Achr723571407-AQP1chr730961680+0.0073475020.9926524
ENST00000297071ENST00000509504TRA2Achr723571407-AQP1chr730961680+0.0073475020.9926524
ENST00000297071ENST00000311813TRA2Achr723571407-AQP1chr730961680+0.0137676220.9862324

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93572_93572_1_TRA2A-AQP1_TRA2A_chr7_23571407_ENST00000297071_AQP1_chr7_30961680_ENST00000311813_length(amino acids)=153AA_BP=12
MSDVEENNFEGRLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF

--------------------------------------------------------------

>93572_93572_2_TRA2A-AQP1_TRA2A_chr7_23571407_ENST00000297071_AQP1_chr7_30961680_ENST00000434909_length(amino acids)=153AA_BP=12
MSDVEENNFEGRLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF

--------------------------------------------------------------

>93572_93572_3_TRA2A-AQP1_TRA2A_chr7_23571407_ENST00000297071_AQP1_chr7_30961680_ENST00000509504_length(amino acids)=153AA_BP=12
MSDVEENNFEGRLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF

--------------------------------------------------------------

>93572_93572_4_TRA2A-AQP1_TRA2A_chr7_23571408_ENST00000297071_AQP1_chr7_30961681_ENST00000311813_length(amino acids)=153AA_BP=12
MSDVEENNFEGRLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF

--------------------------------------------------------------

>93572_93572_5_TRA2A-AQP1_TRA2A_chr7_23571408_ENST00000297071_AQP1_chr7_30961681_ENST00000434909_length(amino acids)=153AA_BP=12
MSDVEENNFEGRLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF

--------------------------------------------------------------

>93572_93572_6_TRA2A-AQP1_TRA2A_chr7_23571408_ENST00000297071_AQP1_chr7_30961681_ENST00000509504_length(amino acids)=153AA_BP=12
MSDVEENNFEGRLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:23571408/chr7:30961681)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AQP1

Q8NBQ7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity). {ECO:0000250|UniProtKB:Q8BHH1, ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:24918044, ECO:0000269|PubMed:31546170}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304159_162128.0270.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104159_16277.0219.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904159_16213.0155.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815159_16245.0187.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304159_162128.0270.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104159_16277.0219.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904159_16213.0155.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815159_16245.0187.0Compositional biasNote=Poly-Arg
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304187_192128.0270.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304193_200128.0270.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104187_19277.0219.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104193_20077.0219.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110477_8477.0219.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904187_19213.0155.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904193_20013.0155.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990471_7613.0155.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990477_8413.0155.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815187_19245.0187.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815193_20045.0187.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281571_7645.0187.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281577_8445.0187.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304187_192128.0270.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304193_200128.0270.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104187_19277.0219.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104193_20077.0219.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110477_8477.0219.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904187_19213.0155.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904193_20013.0155.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990471_7613.0155.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990477_8413.0155.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815187_19245.0187.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815193_20045.0187.0IntramembraneNote=Helical%3B Name%3DHelix E
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281571_7645.0187.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281577_8445.0187.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304192_194128.0270.0MotifNote=NPA 2
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104192_19477.0219.0MotifNote=NPA 2
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110476_7877.0219.0MotifNote=NPA 1
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904192_19413.0155.0MotifNote=NPA 2
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990476_7813.0155.0MotifNote=NPA 1
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815192_19445.0187.0MotifNote=NPA 2
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281576_7845.0187.0MotifNote=NPA 1
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304192_194128.0270.0MotifNote=NPA 2
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104192_19477.0219.0MotifNote=NPA 2
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110476_7877.0219.0MotifNote=NPA 1
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904192_19413.0155.0MotifNote=NPA 2
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990476_7813.0155.0MotifNote=NPA 1
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815192_19445.0187.0MotifNote=NPA 2
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281576_7845.0187.0MotifNote=NPA 1
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304156_166128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304184_186128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304201_207128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304229_269128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104116_13677.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104156_16677.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104184_18677.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104201_20777.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104229_26977.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110485_9477.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904116_13613.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904156_16613.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904184_18613.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904201_20713.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904229_26913.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990437_4813.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990467_7013.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990485_9413.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815116_13645.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815156_16645.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815184_18645.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815201_20745.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815229_26945.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281567_7045.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281585_9445.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304156_166128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304184_186128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304201_207128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304229_269128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104116_13677.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104156_16677.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104184_18677.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104201_20777.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104229_26977.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110485_9477.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904116_13613.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904156_16613.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904184_18613.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904201_20713.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904229_26913.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990437_4813.0155.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990467_7013.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990485_9413.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815116_13645.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815156_16645.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815184_18645.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815201_20745.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815229_26945.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281567_7045.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281585_9445.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304137_155128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304167_183128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304208_228128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104137_15577.0219.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104167_18377.0219.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571407chr7:30961680ENST0000040961104208_22877.0219.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110495_11577.0219.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904137_15513.0155.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904167_18313.0155.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571407chr7:30961680ENST0000040989904208_22813.0155.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990449_6613.0155.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571407chr7:30961680ENST000004098990495_11513.0155.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815137_15545.0187.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815167_18345.0187.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571407chr7:30961680ENST0000044132815208_22845.0187.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281549_6645.0187.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281595_11545.0187.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304137_155128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304167_183128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304208_228128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104137_15577.0219.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104167_18377.0219.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571408chr7:30961681ENST0000040961104208_22877.0219.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110495_11577.0219.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904137_15513.0155.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904167_18313.0155.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571408chr7:30961681ENST0000040989904208_22813.0155.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990449_6613.0155.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571408chr7:30961681ENST000004098990495_11513.0155.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815137_15545.0187.0TransmembraneNote=Helical%3B Name%3DHelix 4
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815167_18345.0187.0TransmembraneNote=Helical%3B Name%3DHelix 5
TgeneAQP1chr7:23571408chr7:30961681ENST0000044132815208_22845.0187.0TransmembraneNote=Helical%3B Name%3DHelix 6
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281549_6645.0187.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281595_11545.0187.0TransmembraneNote=Helical%3B Name%3DHelix 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRA2Achr7:23571407chr7:30961680ENST00000297071-18226_28212.0283.0Compositional biasNote=Arg/Ser-rich (RS2 domain)
HgeneTRA2Achr7:23571407chr7:30961680ENST00000297071-1830_11212.0283.0Compositional biasNote=Arg/Ser-rich (RS1 domain)
HgeneTRA2Achr7:23571408chr7:30961681ENST00000297071-18226_28212.0283.0Compositional biasNote=Arg/Ser-rich (RS2 domain)
HgeneTRA2Achr7:23571408chr7:30961681ENST00000297071-1830_11212.0283.0Compositional biasNote=Arg/Ser-rich (RS1 domain)
HgeneTRA2Achr7:23571407chr7:30961680ENST00000297071-18119_19712.0283.0DomainRRM
HgeneTRA2Achr7:23571408chr7:30961681ENST00000297071-18119_19712.0283.0DomainRRM
HgeneTRA2Achr7:23571407chr7:30961680ENST00000297071-18198_22512.0283.0RegionNote=Linker
HgeneTRA2Achr7:23571408chr7:30961681ENST00000297071-18198_22512.0283.0RegionNote=Linker
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130471_76128.0270.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130477_84128.0270.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110471_7677.0219.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130471_76128.0270.0Intramembrane.
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130477_84128.0270.0IntramembraneNote=Helical%3B Name%3DHelix B
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110471_7677.0219.0Intramembrane.
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130476_78128.0270.0MotifNote=NPA 1
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130476_78128.0270.0MotifNote=NPA 1
TgeneAQP1chr7:23571407chr7:30961680ENST0000031181304116_136128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST00000311813042_7128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130437_48128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130467_70128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130485_94128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST00000409611042_777.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110437_4877.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110467_7077.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST00000409899042_713.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST00000441328152_745.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571407chr7:30961680ENST000004413281537_4845.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST0000031181304116_136128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST00000311813042_7128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130437_48128.0270.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130467_70128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130485_94128.0270.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST00000409611042_777.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110437_4877.0219.0Topological domainExtracellular
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110467_7077.0219.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST00000409899042_713.0155.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST00000441328152_745.0187.0Topological domainCytoplasmic
TgeneAQP1chr7:23571408chr7:30961681ENST000004413281537_4845.0187.0Topological domainExtracellular
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130449_66128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571407chr7:30961680ENST00000311813048_36128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571407chr7:30961680ENST000003118130495_115128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571407chr7:30961680ENST000004096110449_6677.0219.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571407chr7:30961680ENST00000409611048_3677.0219.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571407chr7:30961680ENST00000409899048_3613.0155.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571407chr7:30961680ENST00000441328158_3645.0187.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130449_66128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571408chr7:30961681ENST00000311813048_36128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571408chr7:30961681ENST000003118130495_115128.0270.0TransmembraneNote=Helical%3B Name%3DHelix 3
TgeneAQP1chr7:23571408chr7:30961681ENST000004096110449_6677.0219.0TransmembraneNote=Helical%3B Name%3DHelix 2
TgeneAQP1chr7:23571408chr7:30961681ENST00000409611048_3677.0219.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571408chr7:30961681ENST00000409899048_3613.0155.0TransmembraneNote=Helical%3B Name%3DHelix 1
TgeneAQP1chr7:23571408chr7:30961681ENST00000441328158_3645.0187.0TransmembraneNote=Helical%3B Name%3DHelix 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRA2A
AQP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRA2A-AQP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRA2A-AQP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource