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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIM24-BRAF

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIM24-BRAF
FusionPDB ID: 94004
FusionGDB2.0 ID: 94004
HgeneTgene
Gene symbol

TRIM24

BRAF

Gene ID

8805

673

Gene nametripartite motif containing 24B-Raf proto-oncogene, serine/threonine kinase
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1B-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap

7q33-q34

7q34

Type of geneprotein-codingprotein-coding
Descriptiontranscription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2020031320200329
UniProtAcc

O15164

P15056

Ensembl transtripts involved in fusion geneENST idsENST00000497516, ENST00000343526, 
ENST00000415680, 		ENST00000288602, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 7=63048 X 58 X 16=44544
# samples 1069
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(69/44544*10)=-6.0124909441832
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIM24 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIM24(138255748)-BRAF(140550012), # samples:3
BRAF(140624366)-TRIM24(138258252), # samples:1
Anticipated loss of major functional domain due to fusion event.BRAF-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRAF-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM24-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM24-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM24-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM24-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM24

GO:0016567

protein ubiquitination

19556538

HgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480

TgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across TRIM24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AACL-01ATRIM24chr7

138239609

-BRAFchr7

140550012

-
ChimerDB4READTCGA-F5-6464-01ATRIM24chr7

138255748

-BRAFchr7

140550012

-
ChimerDB4READTCGA-F5-6464-01ATRIM24chr7

138255748

+BRAFchr7

140550012

-
ChimerDB4READTCGA-F5-6464TRIM24chr7

138255748

+BRAFchr7

140550012

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343526TRIM24chr7138255748+ENST00000288602BRAFchr7140550012-437420939242551387
ENST00000415680TRIM24chr7138255748+ENST00000288602BRAFchr7140550012-4171189011440521312
ENST00000343526TRIM24chr7138239609-ENST00000288602BRAFchr7140550012-3859157814793740753
ENST00000415680TRIM24chr7138239609-ENST00000288602BRAFchr7140550012-3823154211437041196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343526ENST00000288602TRIM24chr7138255748+BRAFchr7140550012-0.0007846620.99921536
ENST00000415680ENST00000288602TRIM24chr7138255748+BRAFchr7140550012-0.0007780930.9992219
ENST00000343526ENST00000288602TRIM24chr7138239609-BRAFchr7140550012-0.0009217240.9990783
ENST00000415680ENST00000288602TRIM24chr7138239609-BRAFchr7140550012-0.0004732420.99952674

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94004_94004_1_TRIM24-BRAF_TRIM24_chr7_138239609_ENST00000343526_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=753AA_BP=26
MAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESL
GNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPE
CCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNY
DQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINT
IEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRI
GSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKL
IDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFG
IVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSL

--------------------------------------------------------------

>94004_94004_2_TRIM24-BRAF_TRIM24_chr7_138239609_ENST00000415680_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=1196AA_BP=476
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVII
DTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSG
LSSNQLSKFPTQISLAQLRLQHMQQQVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFS
VSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRI
QDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLF
VSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID
DLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT
VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT
AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM
TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQT

--------------------------------------------------------------

>94004_94004_3_TRIM24-BRAF_TRIM24_chr7_138255748_ENST00000343526_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=1387AA_BP=667
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS
SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQL
LESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRG
LIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLM
CVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNV
HINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITV
GQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFE
MIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV
YAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSAS

--------------------------------------------------------------

>94004_94004_4_TRIM24-BRAF_TRIM24_chr7_138255748_ENST00000415680_BRAF_chr7_140550012_ENST00000288602_length(amino acids)=1312AA_BP=592
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVII
DTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSG
LSSNQLSKFPTQISLAQLRLQHMQQQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSG
QGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEE
YTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCG
VTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTC
GYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHR
NQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRR
DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEG
SSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV
IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:138255748/chr7:140550012)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM24

O15164

BRAF

P15056

FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480}.FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919289_359476.01017.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119289_359626.01051.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119289_359592.01017.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919344_347476.01017.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-9199_15476.01017.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119344_347626.01051.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+11199_15626.01051.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119344_347592.01017.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+11199_15592.01017.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919158_211476.01017.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919218_259476.01017.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-91956_82476.01017.0Zinc fingerRING-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119158_211626.01051.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119218_259626.01051.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+111956_82626.01051.0Zinc fingerRING-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119158_211592.01017.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119218_259592.01017.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+111956_82592.01017.0Zinc fingerRING-type
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018122_12946.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018428_43246.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018122_12946.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018428_43246.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018155_22746.0767.0DomainRBD
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018457_71746.0767.0DomainProtein kinase
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018155_22746.0767.0DomainRBD
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018457_71746.0767.0DomainProtein kinase
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018463_47146.0767.0Nucleotide bindingATP
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018463_47146.0767.0Nucleotide bindingATP
TgeneBRAFchr7:138239609chr7:140550012ENST00000288602018234_28046.0767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr7:138255748chr7:140550012ENST00000288602018234_28046.0767.0Zinc fingerPhorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119289_35901051.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119344_34701051.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-1199_1501051.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119932_98701051.0DomainBromo
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919932_987476.01017.0DomainBromo
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119932_987626.01051.0DomainBromo
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119932_987592.01017.0DomainBromo
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119891_90701051.0MotifNuclear localization signal
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919891_907476.01017.0MotifNuclear localization signal
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119891_907626.01051.0MotifNuclear localization signal
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119891_907592.01017.0MotifNuclear localization signal
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119754_77901051.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919754_779476.01017.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119754_779626.01051.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119754_779592.01017.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119158_21101051.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119218_25901051.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-11956_8201051.0Zinc fingerRING-type
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119826_87301051.0Zinc fingerPHD-type
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919826_873476.01017.0Zinc fingerPHD-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119826_873626.01051.0Zinc fingerPHD-type
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119826_873592.01017.0Zinc fingerPHD-type
TgeneBRAFchr7:138239609chr7:140550012ENST000002886020186_1146.0767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr7:138255748chr7:140550012ENST000002886020186_1146.0767.0Compositional biasNote=Poly-Gly


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2033_TRIM24_138255748_BRAF_140550012_ranked_0.pdbTRIM24138239609138255748ENST00000288602BRAFchr7140550012-
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS
SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQL
LESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRG
LIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLM
CVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNV
HINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITV
GQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFE
MIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV
YAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSAS
1387


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM24_pLDDT.png
all structure
all structure
BRAF_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BRAFYWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, Nedd4, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, Vps4b, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS, HSPA4, DNAJB6, PDCD11, PIP5K1A, DNAJC15, VANGL1, DNAJC11, FKBP5, HSPA4L, HSP90B1, GNAI2, DNAJC13, GNAS, PPP2CB, HSD11B2, DNAJB11, PLD2, RAP1B, WDR6, CPNE3, MYOF, COPA, UBLCP1, PPP1CA, RAD50, PIP4K2C, PHB, VIM, PGAM1, DNAJA1, MAP2K7, SPRY2, ALDOA, AP2B1, ATP5A1, SSB, IGF1R, JUP, PPP6C, PARP1, HSPB1, NME2, PRDX2, CCT7, RAB1A, FARSA, FASN, EPRS, TRAF2, REST, KIAA1429, NANOG, ITCH, SMURF2, WWP1, WWP2, PPP2CA, PPP2R2A, AURKA, LATS2, MAP2K3, MAP2K6, RASSF1, STK11, TERT, PEBP1, CRBN, FAR1, PSMC4, UBA52, UBB, UBC, RPS27A, HSPA6, HSP90AB3P, DSP, ATAD3A, ATAD3B, P4HB, SDF2L1, SLC25A22, SPTBN4, TMEM33, CTSB, NCL, HPX, TXNDC12, SLC25A11, NDUFA4, CTSV, FBP1, HSD17B3, ZNF189, ZNF510, KIF14, SRC, TRAP1, JTB, S100P, USP28,
TRIM24ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1B, DTNBP1, STAT3, NR1I3, SOX2, TNRC6A, UBE2I, MYC, MCM2, SUPT6H, MCM4, PEX5, MCM6, MCM7, SUPT16H, SSRP1, SPOP, FBXO38, PLEKHA4, CREBBP, SMG7, H2AFY, NPM1, H2AFY2, BRD2, SET, ZC3H18, RSF1, MBD1, E2F2, TOP2A, BRPF1, AFF4, PADI2, TFDP2, ZCCHC8, MLKL, PPIH, TFDP1, VPS72, ENPP6, GADD45GIP1, SEZ6L, RAD18, PSD, CDH16, YEATS4, DSC2, MLLT1, RNF43, C10orf71, RCOR2, TANC1, ACTR6, RIBC2, FMN2, RBM7, NOLC1, SRCAP, RNPS1, XPC, MFAP1, DNASE2B, XPO1, TRAF3, UBE2D1, DNAJC19, CEP78, CALM1, SUMO2, SOD1, MARCKS, CALR, PDIA4, DPP7, PTMA, RPS28, PDIA3, HSPE1, CSTB, ALDOA, MOB2, MIF, DDTL, RPRD1B, TPM3, CYCS, STMN1, BASP1, SSB, LCE3D, PGK1, PFN1, TKT, NPC2, PA2G4, TAB1, MARCKSL1, CNPY2, MYL12B, ARHGDIA, MTPN, TPI1, MDH1, PGAM1, TBCA, HMGN1, GGH, PTMS, HSP90B1, MAT2A, ANXA5, PPIB, FABP5, PDIA6, DDX39B, CMBL, TALDO1, TPM4, NUDC, CKB, NUCKS1, GSTO1, HDGF, TAGLN2, PRDX5, PARK7, PEBP1, MYL6, AHSG, SOD2, TRIM37, APEX1, ASF1A, CBX3, HIST1H2BG, TERF2IP, ZNF330, HORMAD2, MAD2L1, ZNF418, ZNF776, CRYAA, ZNF287, ABTB2, CCT8L2, ZNF17, ZNF718, ZNF484, KRT37, NUP62, PIAS4, KXD1, KNSTRN, MAGEA9, NUP62CL, ZNF726, LURAP1, ZNF383, KRT39, TGM7, ZNF460, ZNF543, KRT38, TRIM52, NLRP3, T, ELF1, ELF3, ELF4, ELF5, ERG, ETS1, ETV4, FEV, FOS, GATA2, HNF1B, HNF4A, KLF15, KLF5, KLF6, KLF8, LHX1, LHX2, LHX3, LHX4, MYOD1, NFIC, NFIX, PAX6, SOX17, SOX5, SP7, TLX3, YY1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIM24all structure
BRAFall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIM24chr7:138239609chr7:140550012ENST00000343526-119834_84001051.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138239609chr7:140550012ENST00000415680-919834_840476.01017.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000343526+1119834_840626.01051.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138255748chr7:140550012ENST00000415680+1119834_840592.01017.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)


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Related Drugs to TRIM24-BRAF


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIM24-BRAF


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM24C0238463Papillary thyroid carcinoma2ORPHANET
HgeneTRIM24C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTRIM24C2239176Liver carcinoma1CTD_human
HgeneTRIM24C3658266Prostatic Cancer, Castration-Resistant1CTD_human
HgeneTRIM24C3658267Prostatic Neoplasms, Castration-Resistant1CTD_human
TgeneBRAFC0025202melanoma24CGI;CTD_human;UNIPROT
TgeneBRAFC1275081Cardio-facio-cutaneous syndrome14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneBRAFC0009402Colorectal Carcinoma8CTD_human;UNIPROT
TgeneBRAFC0028326Noonan Syndrome8CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneBRAFC0238463Papillary thyroid carcinoma8CTD_human;ORPHANET
TgeneBRAFC0040136Thyroid Neoplasm6CGI;CTD_human
TgeneBRAFC0151468Thyroid Gland Follicular Adenoma6CTD_human
TgeneBRAFC0175704LEOPARD Syndrome6CLINGEN;GENOMICS_ENGLAND
TgeneBRAFC0549473Thyroid carcinoma6CGI;CTD_human
TgeneBRAFC3150970NOONAN SYNDROME 75CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneBRAFC0009404Colorectal Neoplasms4CTD_human
TgeneBRAFC3150971LEOPARD SYNDROME 34CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneBRAFC1519086Pilomyxoid astrocytoma3ORPHANET
TgeneBRAFC0004565Melanoma, B162CTD_human
TgeneBRAFC0009075Melanoma, Cloudman S912CTD_human
TgeneBRAFC0018598Melanoma, Harding-Passey2CTD_human
TgeneBRAFC0023443Hairy Cell Leukemia2CGI;ORPHANET
TgeneBRAFC0025205Melanoma, Experimental2CTD_human
TgeneBRAFC0033578Prostatic Neoplasms2CTD_human
TgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CGI;CTD_human
TgeneBRAFC0376358Malignant neoplasm of prostate2CTD_human
TgeneBRAFC0587248Costello syndrome (disorder)2CLINGEN;CTD_human
TgeneBRAFC3501843Nonmedullary Thyroid Carcinoma2CTD_human
TgeneBRAFC3501844Familial Nonmedullary Thyroid Cancer2CTD_human
TgeneBRAFC0002448Ameloblastoma1CTD_human
TgeneBRAFC0004114Astrocytoma1CTD_human
TgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneBRAFC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneBRAFC0017638Glioma1CGI;CTD_human
TgeneBRAFC0019621Histiocytosis, Langerhans-Cell1CGI;ORPHANET
TgeneBRAFC0022665Kidney Neoplasm1CTD_human
TgeneBRAFC0023903Liver neoplasms1CTD_human
TgeneBRAFC0024232Lymphatic Metastasis1CTD_human
TgeneBRAFC0024694Mandibular Neoplasms1CTD_human
TgeneBRAFC0027659Neoplasms, Experimental1CTD_human
TgeneBRAFC0027962Melanocytic nevus1GENOMICS_ENGLAND
TgeneBRAFC0036920Sezary Syndrome1CTD_human
TgeneBRAFC0041409Turner Syndrome, Male1CTD_human
TgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneBRAFC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
TgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
TgeneBRAFC0259783mixed gliomas1CTD_human
TgeneBRAFC0278875Adult Craniopharyngioma1CTD_human
TgeneBRAFC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneBRAFC0280785Diffuse Astrocytoma1CTD_human
TgeneBRAFC0334579Anaplastic astrocytoma1CGI;CTD_human
TgeneBRAFC0334580Protoplasmic astrocytoma1CTD_human
TgeneBRAFC0334581Gemistocytic astrocytoma1CTD_human
TgeneBRAFC0334582Fibrillary Astrocytoma1CTD_human
TgeneBRAFC0334583Pilocytic Astrocytoma1CGI;CTD_human
TgeneBRAFC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneBRAFC0345904Malignant neoplasm of liver1CTD_human
TgeneBRAFC0376407Granulomatous Slack Skin1CTD_human
TgeneBRAFC0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
TgeneBRAFC0431128Papillary craniopharyngioma1CTD_human
TgeneBRAFC0431129Adamantinous Craniopharyngioma1CTD_human
TgeneBRAFC0547065Mixed oligoastrocytoma1CTD_human
TgeneBRAFC0555198Malignant Glioma1CTD_human
TgeneBRAFC0596263Carcinogenesis1CTD_human
TgeneBRAFC0684249Carcinoma of lung1CGI;UNIPROT
TgeneBRAFC0740457Malignant neoplasm of kidney1CTD_human
TgeneBRAFC0750935Cerebral Astrocytoma1CTD_human
TgeneBRAFC0750936Intracranial Astrocytoma1CTD_human
TgeneBRAFC0751061Craniopharyngioma, Child1CTD_human
TgeneBRAFC0920269Microsatellite Instability1CTD_human
TgeneBRAFC1527404Female Pseudo-Turner Syndrome1CTD_human
TgeneBRAFC1704230Grade I Astrocytoma1CTD_human
TgeneBRAFC1721098Replication Error Phenotype1CTD_human
TgeneBRAFC2239176Liver carcinoma1CTD_human
TgeneBRAFC4551484Leopard Syndrome 11GENOMICS_ENGLAND
TgeneBRAFC4551602Noonan Syndrome 11CTD_human
TgeneBRAFC4721532Lymphoma, Non-Hodgkin, Familial1UNIPROT
TgeneBRAFC4733333familial non-medullary thyroid cancer1GENOMICS_ENGLAND