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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIT1-ADH1C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIT1-ADH1C
FusionPDB ID: 94267
FusionGDB2.0 ID: 94267
HgeneTgene
Gene symbol

TRIT1

ADH1C

Gene ID

54802

126

Gene nametRNA isopentenyltransferase 1alcohol dehydrogenase 1C (class I), gamma polypeptide
SynonymsCOXPD35|GRO1|IPPT|IPT|IPTase|MOD5|hGRO1ADH3
Cytomap

1p34.2

4q23

Type of geneprotein-codingprotein-coding
DescriptiontRNA dimethylallyltransferaseIPP transferaseisopentenyl-diphosphate:tRNA isopentenyltransferasetRNA dimethylallyltransferase, mitochondrialtRNA isopentenylpyrophosphate transferasealcohol dehydrogenase 1CADH, gamma subunitalcohol dehydrogenase 3 (class I), gamma polypeptidealdehyde reductase
Modification date2020031320200313
UniProtAcc.

P00326

Ensembl transtripts involved in fusion geneENST idsENST00000316891, ENST00000372818, 
ENST00000441669, ENST00000544981, 
ENST00000491865, ENST00000537223, 
ENST00000537440, ENST00000541099, 
ENST00000545233, 
ENST00000510055, 
ENST00000515683, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 2 X 4=563 X 4 X 2=24
# samples 63
** MAII scorelog2(6/56*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIT1 [Title/Abstract] AND ADH1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIT1(40348990)-ADH1C(100268301), # samples:2
Anticipated loss of major functional domain due to fusion event.TRIT1-ADH1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ADH1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ADH1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ADH1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADH1C

GO:0006069

ethanol oxidation

6391957


check buttonFusion gene breakpoints across TRIT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADH1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-PD-A5DF-01ATRIT1chr1

40348990

-ADH1Cchr4

100268301

-
ChimerDB4LIHCTCGA-PD-A5DF-01ATRIT1chr1

40348990

-ADH1Cchr4

100269003

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000441669TRIT1chr140348990-ENST00000515683ADH1Cchr4100268301-14421743901181263
ENST00000316891TRIT1chr140348990-ENST00000515683ADH1Cchr4100268301-14571894051196263
ENST00000372818TRIT1chr140348990-ENST00000515683ADH1Cchr4100268301-14571894051196263
ENST00000544981TRIT1chr140348990-ENST00000515683ADH1Cchr4100268301-14551874031194263
ENST00000441669TRIT1chr140348990-ENST00000515683ADH1Cchr4100269003-15441744921283263
ENST00000316891TRIT1chr140348990-ENST00000515683ADH1Cchr4100269003-15591895071298263
ENST00000372818TRIT1chr140348990-ENST00000515683ADH1Cchr4100269003-15591895071298263
ENST00000544981TRIT1chr140348990-ENST00000515683ADH1Cchr4100269003-15571875051296263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441669ENST00000515683TRIT1chr140348990-ADH1Cchr4100268301-0.0035103450.9964896
ENST00000316891ENST00000515683TRIT1chr140348990-ADH1Cchr4100268301-0.0043060170.9956939
ENST00000372818ENST00000515683TRIT1chr140348990-ADH1Cchr4100268301-0.0043060170.9956939
ENST00000544981ENST00000515683TRIT1chr140348990-ADH1Cchr4100268301-0.0037431150.9962568
ENST00000441669ENST00000515683TRIT1chr140348990-ADH1Cchr4100269003-0.0036974550.9963025
ENST00000316891ENST00000515683TRIT1chr140348990-ADH1Cchr4100269003-0.0040030490.99599695
ENST00000372818ENST00000515683TRIT1chr140348990-ADH1Cchr4100269003-0.0040030490.99599695
ENST00000544981ENST00000515683TRIT1chr140348990-ADH1Cchr4100269003-0.003332080.9966679

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94267_94267_1_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000316891_ADH1C_chr4_100268301_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_2_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000316891_ADH1C_chr4_100269003_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_3_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000372818_ADH1C_chr4_100268301_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_4_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000372818_ADH1C_chr4_100269003_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_5_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000441669_ADH1C_chr4_100268301_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_6_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000441669_ADH1C_chr4_100269003_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_7_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000544981_ADH1C_chr4_100268301_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

>94267_94267_8_TRIT1-ADH1C_TRIT1_chr1_40348990_ENST00000544981_ADH1C_chr4_100269003_ENST00000515683_length(amino acids)=263AA_BP=8
MKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:40348990/chr4:100268301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADH1C

P00326

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-11132_3758.0468.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-11032_3758.0442.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-1932_3758.0386.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-11132_3758.0468.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-11032_3758.0442.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-1932_3758.0386.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-111395_42558.0468.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-110395_42558.0442.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-19395_42558.0386.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-111395_42558.0468.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-110395_42558.0442.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-19395_42558.0386.0Zinc fingerNote=Matrin-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIT1
ADH1C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-111233_25558.0468.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-110233_25558.0442.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-19233_25558.0386.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-111233_25558.0468.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-110233_25558.0442.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-19233_25558.0386.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-111183_18758.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-111281_28358.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-111313_33158.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000316891-111323_33058.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-110183_18758.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-110281_28358.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-110313_33158.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000372818-110323_33058.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-19183_18758.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-19281_28358.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-19313_33158.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100268301ENST00000441669-19323_33058.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-111183_18758.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-111281_28358.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-111313_33158.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000316891-111323_33058.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-110183_18758.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-110281_28358.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-110313_33158.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000372818-110323_33058.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-19183_18758.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-19281_28358.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-19313_33158.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr4:100269003ENST00000441669-19323_33058.0386.0substrate tRNA


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Related Drugs to TRIT1-ADH1C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIT1-ADH1C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource