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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TTC3-UBR5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TTC3-UBR5
	FusionPDB ID: 95071
	FusionGDB2.0 ID: 95071
		Hgene	Tgene
	Gene symbol	TTC3	UBR5
	Gene ID	7267	51366
	Gene name	tetratricopeptide repeat domain 3	ubiquitin protein ligase E3 component n-recognin 5
	Synonyms	DCRR1\|RNF105\|TPRDIII	DD5\|EDD\|EDD1\|HYD
	Cytomap	21q22.13	8q22.3
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3	E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
	Modification date	20200320	20200315
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000479930, ENST00000354749, ENST00000355666, ENST00000399017, ENST00000399010, ENST00000540756,	ENST00000220959, ENST00000518205, ENST00000520539, ENST00000521922, ENST00000519528,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 15 X 11=3300	14 X 17 X 10=2380
	# samples	20	19
	** MAII score	log2(20/3300*10)=-4.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2380*10)=-3.64689024986436 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TTC3 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TTC3(38538884)-UBR5(103273392), # samples:1
Anticipated loss of major functional domain due to fusion event.	TTC3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TTC3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TTC3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TTC3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TTC3	GO:0006511	ubiquitin-dependent protein catabolic process	20059950
Hgene	TTC3	GO:0070936	protein K48-linked ubiquitination	20059950
Tgene	UBR5	GO:0000209	protein polyubiquitination	21118991\|28689657
Tgene	UBR5	GO:0006974	cellular response to DNA damage stimulus	12011095
Tgene	UBR5	GO:0010628	positive regulation of gene expression	18076571
Tgene	UBR5	GO:0050847	progesterone receptor signaling pathway	12011095
Tgene	UBR5	GO:0070936	protein K48-linked ubiquitination	28689657

Fusion gene breakpoints across TTC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AW363719	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000355666	TTC3	chr21	38538884	+	ENST00000520539	UBR5	chr8	103273392	-	5226	3473	96	3548	1150
ENST00000355666	TTC3	chr21	38538884	+	ENST00000220959	UBR5	chr8	103273392	-	4502	3473	96	3548	1150
ENST00000355666	TTC3	chr21	38538884	+	ENST00000518205	UBR5	chr8	103273392	-	4040	3473	96	3548	1150
ENST00000355666	TTC3	chr21	38538884	+	ENST00000521922	UBR5	chr8	103273392	-	4040	3473	96	3548	1150
ENST00000399017	TTC3	chr21	38538884	+	ENST00000520539	UBR5	chr8	103273392	-	7868	6115	2708	6190	1160
ENST00000399017	TTC3	chr21	38538884	+	ENST00000220959	UBR5	chr8	103273392	-	7144	6115	2708	6190	1160
ENST00000399017	TTC3	chr21	38538884	+	ENST00000518205	UBR5	chr8	103273392	-	6682	6115	2708	6190	1160
ENST00000399017	TTC3	chr21	38538884	+	ENST00000521922	UBR5	chr8	103273392	-	6682	6115	2708	6190	1160
ENST00000354749	TTC3	chr21	38538884	+	ENST00000520539	UBR5	chr8	103273392	-	6589	4836	1459	4911	1150
ENST00000354749	TTC3	chr21	38538884	+	ENST00000220959	UBR5	chr8	103273392	-	5865	4836	1459	4911	1150
ENST00000354749	TTC3	chr21	38538884	+	ENST00000518205	UBR5	chr8	103273392	-	5403	4836	1459	4911	1150
ENST00000354749	TTC3	chr21	38538884	+	ENST00000521922	UBR5	chr8	103273392	-	5403	4836	1459	4911	1150

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355666	ENST00000520539	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000164717	0.99983525
ENST00000355666	ENST00000220959	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000251448	0.9997485
ENST00000355666	ENST00000518205	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000318029	0.99968195
ENST00000355666	ENST00000521922	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000318029	0.99968195
ENST00000399017	ENST00000520539	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.002091863	0.9979081
ENST00000399017	ENST00000220959	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.002309551	0.99769044
ENST00000399017	ENST00000518205	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.002475191	0.9975248
ENST00000399017	ENST00000521922	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.002475191	0.9975248
ENST00000354749	ENST00000520539	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000656873	0.9993431
ENST00000354749	ENST00000220959	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000814214	0.99918574
ENST00000354749	ENST00000518205	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000906678	0.9990933
ENST00000354749	ENST00000521922	TTC3	chr21	38538884	+	UBR5	chr8	103273392	-	0.000906678	0.9990933

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95071_95071_1_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000220959_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_2_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000518205_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_3_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000520539_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_4_TTC3-UBR5_TTC3_chr21_38538884_ENST00000354749_UBR5_chr8_103273392_ENST00000521922_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_5_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000220959_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_6_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000518205_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_7_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000520539_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_8_TTC3-UBR5_TTC3_chr21_38538884_ENST00000355666_UBR5_chr8_103273392_ENST00000521922_length(amino acids)=1150AA_BP=
MCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKI
NIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGD
VTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLL
YGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRT
ANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNN
ESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVL
VVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQP
QKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPD
CEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETV
DNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELK
EVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALH
SALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDV

--------------------------------------------------------------

>95071_95071_9_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000220959_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------

>95071_95071_10_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000518205_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------

>95071_95071_11_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000520539_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------

>95071_95071_12_TTC3-UBR5_TTC3_chr21_38538884_ENST00000399017_UBR5_chr8_103273392_ENST00000521922_length(amino acids)=1160AA_BP=
MRRKWSTASNLCTMDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISV
LQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEE
ALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRA
IEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ
KQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPK
HKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQ
LNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPT
SNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKD
FLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNP
PKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTR
IFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLE
EHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:38538884/chr8:103273392)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

1528_1537

2800.0

Compositional bias

Note=Poly-Ser

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

1671_1681

2800.0

Compositional bias

Note=Poly-Ser

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

1762_1768

2800.0

Compositional bias

Note=Poly-Ala

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

1986_1997

2800.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2036_2059

2800.0

Compositional bias

Note=Pro-rich

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2329_2348

2800.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2357_2366

2800.0

Compositional bias

Note=Arg/Asp-rich (mixed charge)

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2489_2500

2800.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2737_2757

2800.0

Compositional bias

Note=Pro-rich

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

940_945

2800.0

Compositional bias

Note=Poly-Glu

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

980_985

2800.0

Compositional bias

Note=Poly-Ser

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2377_2454

2800.0

Domain

PABC

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

2462_2799

2800.0

Domain

HECT

Tgene

UBR5

chr21:38538884

chr8:103273392

ENST00000520539

1177_1245

2800.0

Zinc finger

UBR-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

1018_1029

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

1020_1029

2026.0

Compositional bias

Note=Poly-Lys

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

1172_1185

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

1563_1579

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

1899_1902

2026.0

Compositional bias

Note=Poly-Lys

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

453_456

2026.0

Compositional bias

Note=Poly-Ser

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

1018_1029

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

1020_1029

2026.0

Compositional bias

Note=Poly-Lys

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

1172_1185

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

1563_1579

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

1899_1902

2026.0

Compositional bias

Note=Poly-Lys

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

453_456

2026.0

Compositional bias

Note=Poly-Ser

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

1018_1029

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

1020_1029

2026.0

Compositional bias

Note=Poly-Lys

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

1172_1185

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

1563_1579

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

1899_1902

2026.0

Compositional bias

Note=Poly-Lys

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

453_456

2026.0

Compositional bias

Note=Poly-Ser

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

231_264

2026.0

Repeat

Note=TPR 1

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

266_298

2026.0

Repeat

Note=TPR 2

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

536_572

2026.0

Repeat

Note=TPR 3

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

576_609

2026.0

Repeat

Note=TPR 4

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

231_264

2026.0

Repeat

Note=TPR 1

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

266_298

2026.0

Repeat

Note=TPR 2

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

536_572

2026.0

Repeat

Note=TPR 3

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

576_609

2026.0

Repeat

Note=TPR 4

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

231_264

2026.0

Repeat

Note=TPR 1

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

266_298

2026.0

Repeat

Note=TPR 2

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

536_572

2026.0

Repeat

Note=TPR 3

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

576_609

2026.0

Repeat

Note=TPR 4

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000354749

1957_1997

2026.0

Zinc finger

RING-type

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000355666

1957_1997

2026.0

Zinc finger

RING-type

Hgene

TTC3

chr21:38538884

chr8:103273392

ENST00000399017

1957_1997

2026.0

Zinc finger

RING-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TTC3
UBR5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TTC3	chr21:38538884	chr8:103273392	ENST00000354749	+	1	45	1_230	0	2026.0	POLG
Hgene	TTC3	chr21:38538884	chr8:103273392	ENST00000355666	+	1	46	1_230	0	2026.0	POLG
Hgene	TTC3	chr21:38538884	chr8:103273392	ENST00000399017	+	1	46	1_230	0	2026.0	POLG

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Related Drugs to TTC3-UBR5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TTC3-UBR5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source