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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TUBD1-CDK12

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TUBD1-CDK12
FusionPDB ID: 95378
FusionGDB2.0 ID: 95378
HgeneTgene
Gene symbol

TUBD1

CDK12

Gene ID

51174

51755

Gene nametubulin delta 1cyclin dependent kinase 12
SynonymsTUBDCRK7|CRKR|CRKRS
Cytomap

17q23.1

17q12

Type of geneprotein-codingprotein-coding
Descriptiontubulin delta chaindelta-tubulincyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020031320200313
UniProtAcc.

Q9NYV4

Ensembl transtripts involved in fusion geneENST idsENST00000325752, ENST00000340993, 
ENST00000346141, ENST00000376094, 
ENST00000394239, ENST00000539018, 
ENST00000592426, ENST00000591611, 
ENST00000559545, ENST00000430627, 
ENST00000447079, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 16 X 8=204836 X 30 X 14=15120
# samples 2255
** MAII scorelog2(22/2048*10)=-3.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TUBD1 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TUBD1(57943970)-CDK12(37667782), # samples:3
Anticipated loss of major functional domain due to fusion event.TUBD1-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TUBD1-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across TUBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01ATUBD1chr17

57943969

-CDK12chr17

37667781

+
ChimerDB4BRCATCGA-A1-A0SN-01ATUBD1chr17

57943970

-CDK12chr17

37667782

+
ChimerDB4BRCATCGA-A1-A0SN-01ATUBD1chr17

57951899

-CDK12chr17

37667781

+
ChimerDB4BRCATCGA-A1-A0SN-01ATUBD1chr17

57951900

-CDK12chr17

37667782

+
ChimerDB4BRCATCGA-A1-A0SN-01ATUBD1chr17

57955464

-CDK12chr17

37667782

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346141TUBD1chr1757943970-ENST00000430627CDK12chr1737667782+33123713992150583
ENST00000346141TUBD1chr1757943970-ENST00000447079CDK12chr1737667782+60083713992177592
ENST00000325752TUBD1chr1757943970-ENST00000430627CDK12chr1737667782+4294135313813132583
ENST00000325752TUBD1chr1757943970-ENST00000447079CDK12chr1737667782+6990135313813159592
ENST00000340993TUBD1chr1757943970-ENST00000430627CDK12chr1737667782+4114117312012952583
ENST00000340993TUBD1chr1757943970-ENST00000447079CDK12chr1737667782+6810117312012979592
ENST00000325752TUBD1chr1757951900-ENST00000430627CDK12chr1737667782+4153121212402991583
ENST00000325752TUBD1chr1757951900-ENST00000447079CDK12chr1737667782+6849121212403018592
ENST00000394239TUBD1chr1757951900-ENST00000430627CDK12chr1737667782+4076113511632914583
ENST00000394239TUBD1chr1757951900-ENST00000447079CDK12chr1737667782+6772113511632941592
ENST00000325752TUBD1chr1757955464-ENST00000430627CDK12chr1737667782+3988104710752826583
ENST00000325752TUBD1chr1757955464-ENST00000447079CDK12chr1737667782+6684104710752853592
ENST00000340993TUBD1chr1757955464-ENST00000430627CDK12chr1737667782+3973103210602811583
ENST00000340993TUBD1chr1757955464-ENST00000447079CDK12chr1737667782+6669103210602838592
ENST00000394239TUBD1chr1757955464-ENST00000430627CDK12chr1737667782+39119709982749583
ENST00000394239TUBD1chr1757955464-ENST00000447079CDK12chr1737667782+66079709982776592
ENST00000346141TUBD1chr1757943969-ENST00000430627CDK12chr1737667781+33123713992150583
ENST00000346141TUBD1chr1757943969-ENST00000447079CDK12chr1737667781+60083713992177592
ENST00000325752TUBD1chr1757943969-ENST00000430627CDK12chr1737667781+4294135313813132583
ENST00000325752TUBD1chr1757943969-ENST00000447079CDK12chr1737667781+6990135313813159592
ENST00000340993TUBD1chr1757943969-ENST00000430627CDK12chr1737667781+4114117312012952583
ENST00000340993TUBD1chr1757943969-ENST00000447079CDK12chr1737667781+6810117312012979592
ENST00000325752TUBD1chr1757951899-ENST00000430627CDK12chr1737667781+4153121212402991583
ENST00000325752TUBD1chr1757951899-ENST00000447079CDK12chr1737667781+6849121212403018592
ENST00000394239TUBD1chr1757951899-ENST00000430627CDK12chr1737667781+4076113511632914583
ENST00000394239TUBD1chr1757951899-ENST00000447079CDK12chr1737667781+6772113511632941592

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346141ENST00000430627TUBD1chr1757943970-CDK12chr1737667782+0.0056276920.99437225
ENST00000346141ENST00000447079TUBD1chr1757943970-CDK12chr1737667782+0.0008826930.9991173
ENST00000325752ENST00000430627TUBD1chr1757943970-CDK12chr1737667782+0.0036724760.99632746
ENST00000325752ENST00000447079TUBD1chr1757943970-CDK12chr1737667782+0.0010977530.9989022
ENST00000340993ENST00000430627TUBD1chr1757943970-CDK12chr1737667782+0.0037415950.9962584
ENST00000340993ENST00000447079TUBD1chr1757943970-CDK12chr1737667782+0.0010393890.9989606
ENST00000325752ENST00000430627TUBD1chr1757951900-CDK12chr1737667782+0.0043324360.9956676
ENST00000325752ENST00000447079TUBD1chr1757951900-CDK12chr1737667782+0.0011458760.99885416
ENST00000394239ENST00000430627TUBD1chr1757951900-CDK12chr1737667782+0.0044570520.99554294
ENST00000394239ENST00000447079TUBD1chr1757951900-CDK12chr1737667782+0.0011331920.9988668
ENST00000325752ENST00000430627TUBD1chr1757955464-CDK12chr1737667782+0.0044911680.9955088
ENST00000325752ENST00000447079TUBD1chr1757955464-CDK12chr1737667782+0.0010910550.998909
ENST00000340993ENST00000430627TUBD1chr1757955464-CDK12chr1737667782+0.0044339280.99556607
ENST00000340993ENST00000447079TUBD1chr1757955464-CDK12chr1737667782+0.0010861550.9989139
ENST00000394239ENST00000430627TUBD1chr1757955464-CDK12chr1737667782+0.00464560.9953544
ENST00000394239ENST00000447079TUBD1chr1757955464-CDK12chr1737667782+0.001079010.99892104
ENST00000346141ENST00000430627TUBD1chr1757943969-CDK12chr1737667781+0.0056276920.99437225
ENST00000346141ENST00000447079TUBD1chr1757943969-CDK12chr1737667781+0.0008826930.9991173
ENST00000325752ENST00000430627TUBD1chr1757943969-CDK12chr1737667781+0.0036724760.99632746
ENST00000325752ENST00000447079TUBD1chr1757943969-CDK12chr1737667781+0.0010977530.9989022
ENST00000340993ENST00000430627TUBD1chr1757943969-CDK12chr1737667781+0.0037415950.9962584
ENST00000340993ENST00000447079TUBD1chr1757943969-CDK12chr1737667781+0.0010393890.9989606
ENST00000325752ENST00000430627TUBD1chr1757951899-CDK12chr1737667781+0.0043324360.9956676
ENST00000325752ENST00000447079TUBD1chr1757951899-CDK12chr1737667781+0.0011458760.99885416
ENST00000394239ENST00000430627TUBD1chr1757951899-CDK12chr1737667781+0.0044570520.99554294
ENST00000394239ENST00000447079TUBD1chr1757951899-CDK12chr1737667781+0.0011331920.9988668

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95378_95378_1_TUBD1-CDK12_TUBD1_chr17_57943969_ENST00000325752_CDK12_chr17_37667781_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_2_TUBD1-CDK12_TUBD1_chr17_57943969_ENST00000325752_CDK12_chr17_37667781_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_3_TUBD1-CDK12_TUBD1_chr17_57943969_ENST00000340993_CDK12_chr17_37667781_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_4_TUBD1-CDK12_TUBD1_chr17_57943969_ENST00000340993_CDK12_chr17_37667781_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_5_TUBD1-CDK12_TUBD1_chr17_57943969_ENST00000346141_CDK12_chr17_37667781_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_6_TUBD1-CDK12_TUBD1_chr17_57943969_ENST00000346141_CDK12_chr17_37667781_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_7_TUBD1-CDK12_TUBD1_chr17_57943970_ENST00000325752_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_8_TUBD1-CDK12_TUBD1_chr17_57943970_ENST00000325752_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_9_TUBD1-CDK12_TUBD1_chr17_57943970_ENST00000340993_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_10_TUBD1-CDK12_TUBD1_chr17_57943970_ENST00000340993_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_11_TUBD1-CDK12_TUBD1_chr17_57943970_ENST00000346141_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_12_TUBD1-CDK12_TUBD1_chr17_57943970_ENST00000346141_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_13_TUBD1-CDK12_TUBD1_chr17_57951899_ENST00000325752_CDK12_chr17_37667781_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_14_TUBD1-CDK12_TUBD1_chr17_57951899_ENST00000325752_CDK12_chr17_37667781_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_15_TUBD1-CDK12_TUBD1_chr17_57951899_ENST00000394239_CDK12_chr17_37667781_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_16_TUBD1-CDK12_TUBD1_chr17_57951899_ENST00000394239_CDK12_chr17_37667781_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_17_TUBD1-CDK12_TUBD1_chr17_57951900_ENST00000325752_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_18_TUBD1-CDK12_TUBD1_chr17_57951900_ENST00000325752_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_19_TUBD1-CDK12_TUBD1_chr17_57951900_ENST00000394239_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_20_TUBD1-CDK12_TUBD1_chr17_57951900_ENST00000394239_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_21_TUBD1-CDK12_TUBD1_chr17_57955464_ENST00000325752_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_22_TUBD1-CDK12_TUBD1_chr17_57955464_ENST00000325752_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_23_TUBD1-CDK12_TUBD1_chr17_57955464_ENST00000340993_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_24_TUBD1-CDK12_TUBD1_chr17_57955464_ENST00000340993_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

>95378_95378_25_TUBD1-CDK12_TUBD1_chr17_57955464_ENST00000394239_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=583AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPP
EPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN
SGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGT

--------------------------------------------------------------

>95378_95378_26_TUBD1-CDK12_TUBD1_chr17_57955464_ENST00000394239_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=592AA_BP=
MWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSF
IPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEP
VKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQ
DSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPH
ILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGF
SAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57943970/chr17:37667782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDK12

Q9NYV4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBD1chr17:57943969chr17:37667781ENST00000325752-79143_149358.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943969chr17:37667781ENST00000340993-68143_149303.3333333333333399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943969chr17:37667781ENST00000592426-68143_149358.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000325752-79143_149358.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000340993-68143_149303.3333333333333399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000592426-68143_149358.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000325752-69143_149311.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000394239-68143_149311.3333333333333397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000592426-58143_149311.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000325752-69143_149311.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000394239-68143_149311.3333333333333397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000592426-58143_149311.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000325752-59143_149256.3333333333333454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000340993-58143_149256.3333333333333399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000376094-46143_149256.3333333333333352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000394239-58143_149256.3333333333333397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000592426-48143_149256.3333333333333454.0Nucleotide bindingGTP
TgeneCDK12chr17:57943969chr17:37667781ENST000004306276141266_1280888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943969chr17:37667781ENST000004470796141266_1280888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943970chr17:37667782ENST000004306276141266_1280888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943970chr17:37667782ENST000004470796141266_1280888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951899chr17:37667781ENST000004306276141266_1280888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951899chr17:37667781ENST000004470796141266_1280888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951900chr17:37667782ENST000004306276141266_1280888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951900chr17:37667782ENST000004470796141266_1280888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57955464chr17:37667782ENST000004306276141266_1280888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57955464chr17:37667782ENST000004470796141266_1280888.66666666666661491.0Compositional biasNote=Poly-Pro

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBD1chr17:57943969chr17:37667781ENST00000346141-35143_149104.33333333333333200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943969chr17:37667781ENST00000376094-16143_1490352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943969chr17:37667781ENST00000394239-18143_1490397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943969chr17:37667781ENST00000539018-46143_149142.33333333333334238.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000346141-35143_149104.33333333333333200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000376094-16143_1490352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000394239-18143_1490397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57943970chr17:37667782ENST00000539018-46143_149142.33333333333334238.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000340993-18143_1490399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000346141-15143_1490200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000376094-16143_1490352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951899chr17:37667781ENST00000539018-36143_14995.33333333333333238.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000340993-18143_1490399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000346141-15143_1490200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000376094-16143_1490352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57951900chr17:37667782ENST00000539018-36143_14995.33333333333333238.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000346141-15143_1490200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57955464chr17:37667782ENST00000539018-26143_14940.333333333333336238.0Nucleotide bindingGTP
TgeneCDK12chr17:57943969chr17:37667781ENST00000430627614407_413888.66666666666661482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57943969chr17:37667781ENST00000430627614535_540888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943969chr17:37667781ENST00000447079614407_413888.66666666666661491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57943969chr17:37667781ENST00000447079614535_540888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943970chr17:37667782ENST00000430627614407_413888.66666666666661482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57943970chr17:37667782ENST00000430627614535_540888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943970chr17:37667782ENST00000447079614407_413888.66666666666661491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57943970chr17:37667782ENST00000447079614535_540888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951899chr17:37667781ENST00000430627614407_413888.66666666666661482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57951899chr17:37667781ENST00000430627614535_540888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951899chr17:37667781ENST00000447079614407_413888.66666666666661491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57951899chr17:37667781ENST00000447079614535_540888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951900chr17:37667782ENST00000430627614407_413888.66666666666661482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57951900chr17:37667782ENST00000430627614535_540888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57951900chr17:37667782ENST00000447079614407_413888.66666666666661491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57951900chr17:37667782ENST00000447079614535_540888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57955464chr17:37667782ENST00000430627614407_413888.66666666666661482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57955464chr17:37667782ENST00000430627614535_540888.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57955464chr17:37667782ENST00000447079614407_413888.66666666666661491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:57955464chr17:37667782ENST00000447079614535_540888.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:57943969chr17:37667781ENST00000430627614727_1020888.66666666666661482.0DomainProtein kinase
TgeneCDK12chr17:57943969chr17:37667781ENST00000447079614727_1020888.66666666666661491.0DomainProtein kinase
TgeneCDK12chr17:57943970chr17:37667782ENST00000430627614727_1020888.66666666666661482.0DomainProtein kinase
TgeneCDK12chr17:57943970chr17:37667782ENST00000447079614727_1020888.66666666666661491.0DomainProtein kinase
TgeneCDK12chr17:57951899chr17:37667781ENST00000430627614727_1020888.66666666666661482.0DomainProtein kinase
TgeneCDK12chr17:57951899chr17:37667781ENST00000447079614727_1020888.66666666666661491.0DomainProtein kinase
TgeneCDK12chr17:57951900chr17:37667782ENST00000430627614727_1020888.66666666666661482.0DomainProtein kinase
TgeneCDK12chr17:57951900chr17:37667782ENST00000447079614727_1020888.66666666666661491.0DomainProtein kinase
TgeneCDK12chr17:57955464chr17:37667782ENST00000430627614727_1020888.66666666666661482.0DomainProtein kinase
TgeneCDK12chr17:57955464chr17:37667782ENST00000447079614727_1020888.66666666666661491.0DomainProtein kinase
TgeneCDK12chr17:57943969chr17:37667781ENST00000430627614733_741888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943969chr17:37667781ENST00000430627614814_819888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943969chr17:37667781ENST00000447079614733_741888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943969chr17:37667781ENST00000447079614814_819888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943970chr17:37667782ENST00000430627614733_741888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943970chr17:37667782ENST00000430627614814_819888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943970chr17:37667782ENST00000447079614733_741888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57943970chr17:37667782ENST00000447079614814_819888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951899chr17:37667781ENST00000430627614733_741888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951899chr17:37667781ENST00000430627614814_819888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951899chr17:37667781ENST00000447079614733_741888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951899chr17:37667781ENST00000447079614814_819888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951900chr17:37667782ENST00000430627614733_741888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951900chr17:37667782ENST00000430627614814_819888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951900chr17:37667782ENST00000447079614733_741888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57951900chr17:37667782ENST00000447079614814_819888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57955464chr17:37667782ENST00000430627614733_741888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57955464chr17:37667782ENST00000430627614814_819888.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57955464chr17:37667782ENST00000447079614733_741888.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:57955464chr17:37667782ENST00000447079614814_819888.66666666666661491.0Nucleotide bindingNote=ATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TUBD1
CDK12


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TUBD1-CDK12


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TUBD1-CDK12


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource