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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UBE4B-PLEKHG5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UBE4B-PLEKHG5
	FusionPDB ID: 96333
	FusionGDB2.0 ID: 96333
		Hgene	Tgene
	Gene symbol	UBE4B	PLEKHG5
	Gene ID	10277	57449
	Gene name	ubiquitination factor E4B	pleckstrin homology and RhoGEF domain containing G5
	Synonyms	E4\|HDNB1\|UBOX3\|UFD2\|UFD2A	CMTRIC\|DSMA4\|GEF720\|Syx\|Tech
	Cytomap	1p36.22	1p36.31
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, y	pleckstrin homology domain-containing family G member 5NFkB activating proteinPH domain-containing family G member 5guanine nucleotide exchange factor 720novel PH domain-containing proteinpleckstrin homology domain containing, family G (with RhoGef d
	Modification date	20200313	20200320
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000253251, ENST00000343090, ENST00000377153, ENST00000377157, ENST00000475795,	ENST00000340850, ENST00000377725, ENST00000377728, ENST00000377732, ENST00000377737, ENST00000377740, ENST00000400913, ENST00000400915, ENST00000535355, ENST00000537245, ENST00000544978, ENST00000377748,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 13 X 10=2340	4 X 3 X 4=48
	# samples	23	6
	** MAII score	log2(23/2340*10)=-3.34680276352639 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UBE4B [Title/Abstract] AND PLEKHG5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UBE4B(10093752)-PLEKHG5(6556629), # samples:2
Anticipated loss of major functional domain due to fusion event.	UBE4B-PLEKHG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UBE4B-PLEKHG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UBE4B-PLEKHG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UBE4B-PLEKHG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UBE4B-PLEKHG5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBE4B	GO:0008626	granzyme-mediated apoptotic signaling pathway	11802788
Hgene	UBE4B	GO:0009411	response to UV	11802788
Hgene	UBE4B	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	23509263

Fusion gene breakpoints across UBE4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLEKHG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-56-7730-01A	UBE4B	chr1	10093752	-	PLEKHG5	chr1	6556629	-
ChimerDB4	LUSC	TCGA-56-7730-01A	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6556629	-
ChimerDB4	LUSC	TCGA-56-7730	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000253251	UBE4B	chr1	10093752	+	ENST00000377748	PLEKHG5	chr1	6537718	-	5442	863	839	3970	1043
ENST00000253251	UBE4B	chr1	10093752	+	ENST00000377732	PLEKHG5	chr1	6537718	-	4412	863	839	3970	1043
ENST00000253251	UBE4B	chr1	10093752	+	ENST00000400915	PLEKHG5	chr1	6537718	-	4412	863	839	3970	1043
ENST00000253251	UBE4B	chr1	10093752	+	ENST00000377740	PLEKHG5	chr1	6537718	-	3719	863	839	3277	812
ENST00000343090	UBE4B	chr1	10093752	+	ENST00000377748	PLEKHG5	chr1	6537718	-	4678	99	75	3206	1043
ENST00000343090	UBE4B	chr1	10093752	+	ENST00000377732	PLEKHG5	chr1	6537718	-	3648	99	75	3206	1043
ENST00000343090	UBE4B	chr1	10093752	+	ENST00000400915	PLEKHG5	chr1	6537718	-	3648	99	75	3206	1043
ENST00000343090	UBE4B	chr1	10093752	+	ENST00000377740	PLEKHG5	chr1	6537718	-	2955	99	75	2513	812
ENST00000377153	UBE4B	chr1	10093752	+	ENST00000377748	PLEKHG5	chr1	6537718	-	5000	421	397	3528	1043
ENST00000377153	UBE4B	chr1	10093752	+	ENST00000377732	PLEKHG5	chr1	6537718	-	3970	421	397	3528	1043
ENST00000377153	UBE4B	chr1	10093752	+	ENST00000400915	PLEKHG5	chr1	6537718	-	3970	421	397	3528	1043
ENST00000377153	UBE4B	chr1	10093752	+	ENST00000377740	PLEKHG5	chr1	6537718	-	3277	421	397	2835	812

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000253251	ENST00000377748	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.008805921	0.99119407
ENST00000253251	ENST00000377732	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.010236774	0.98976326
ENST00000253251	ENST00000400915	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.010236774	0.98976326
ENST00000253251	ENST00000377740	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.01088927	0.98911077
ENST00000343090	ENST00000377748	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.00490252	0.99509746
ENST00000343090	ENST00000377732	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.006059791	0.99394023
ENST00000343090	ENST00000400915	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.006059791	0.99394023
ENST00000343090	ENST00000377740	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.014210951	0.985789
ENST00000377153	ENST00000377748	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.007028442	0.9929716
ENST00000377153	ENST00000377732	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.008702754	0.99129725
ENST00000377153	ENST00000400915	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.008702754	0.99129725
ENST00000377153	ENST00000377740	UBE4B	chr1	10093752	+	PLEKHG5	chr1	6537718	-	0.015159591	0.98484045

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96333_96333_1_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000253251_PLEKHG5_chr1_6537718_ENST00000377732_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_2_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000253251_PLEKHG5_chr1_6537718_ENST00000377740_length(amino acids)=812AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHWKLTLAQLYRIRTTLLLNSTLTAS

--------------------------------------------------------------

>96333_96333_3_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000253251_PLEKHG5_chr1_6537718_ENST00000377748_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_4_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000253251_PLEKHG5_chr1_6537718_ENST00000400915_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_5_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000343090_PLEKHG5_chr1_6537718_ENST00000377732_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_6_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000343090_PLEKHG5_chr1_6537718_ENST00000377740_length(amino acids)=812AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHWKLTLAQLYRIRTTLLLNSTLTAS

--------------------------------------------------------------

>96333_96333_7_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000343090_PLEKHG5_chr1_6537718_ENST00000377748_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_8_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000343090_PLEKHG5_chr1_6537718_ENST00000400915_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_9_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000377153_PLEKHG5_chr1_6537718_ENST00000377732_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_10_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000377153_PLEKHG5_chr1_6537718_ENST00000377740_length(amino acids)=812AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHWKLTLAQLYRIRTTLLLNSTLTAS

--------------------------------------------------------------

>96333_96333_11_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000377153_PLEKHG5_chr1_6537718_ENST00000377748_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

>96333_96333_12_UBE4B-PLEKHG5_UBE4B_chr1_10093752_ENST00000377153_PLEKHG5_chr1_6537718_ENST00000400915_length(amino acids)=1043AA_BP=3
MEELSADEVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRK
STGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYL
RVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSS
GSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWREL
IDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTR
ALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE
EPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM
KEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQ
NQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSP
EFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTP
VQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:10093752/chr1:6556629)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000340850

38_43

1007.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377725

38_43

1020.6666666666666

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377728

38_43

1007.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377732

38_43

8.0

1044.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377737

38_43

1007.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000400913

38_43

1007.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000400915

38_43

27.0

1063.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000535355

38_43

40.0

1076.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000544978

38_43

931.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000340850

336_528

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000340850

584_684

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377725

336_528

1020.6666666666666

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377725

584_684

1020.6666666666666

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377728

336_528

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377728

584_684

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377732

336_528

8.0

1044.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377732

584_684

8.0

1044.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377737

336_528

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377737

584_684

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377748

336_528

48.0

1084.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377748

584_684

48.0

1084.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000400913

336_528

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000400913

584_684

1007.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000400915

336_528

27.0

1063.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000400915

584_684

27.0

1063.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000535355

336_528

40.0

1076.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000535355

584_684

40.0

1076.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000537245

336_528

50.0

1086.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000537245

584_684

50.0

1086.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000544978

336_528

931.0

Domain

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000544978

584_684

931.0

Domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBE4B

chr1:10093752

chr1:6537718

ENST00000253251

1227_1300

8.0

1174.0

Domain

Note=U-box

Hgene

UBE4B

chr1:10093752

chr1:6537718

ENST00000343090

1227_1300

8.0

1303.0

Domain

Note=U-box

Hgene

UBE4B

chr1:10093752

chr1:6537718

ENST00000377157

1227_1300

1062.0

Domain

Note=U-box

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000377748

38_43

48.0

1084.0

Compositional bias

Note=Poly-Glu

Tgene

PLEKHG5

chr1:10093752

chr1:6537718

ENST00000537245

38_43

50.0

1086.0

Compositional bias

Note=Poly-Glu

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UBE4B
PLEKHG5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to UBE4B-PLEKHG5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to UBE4B-PLEKHG5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source