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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:VPS53-UBR5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: VPS53-UBR5
	FusionPDB ID: 98493
	FusionGDB2.0 ID: 98493
		Hgene	Tgene
	Gene symbol	VPS53	UBR5
	Gene ID	55275	51366
	Gene name	VPS53 subunit of GARP complex	ubiquitin protein ligase E3 component n-recognin 5
	Synonyms	HCCS1\|PCH2E\|hVps53L\|pp13624	DD5\|EDD\|EDD1\|HYD
	Cytomap	17p13.3	8q22.3
	Type of gene	protein-coding	protein-coding
	Description	vacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunit	E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
	Modification date	20200313	20200315
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000291074, ENST00000437048, ENST00000446250, ENST00000571805, ENST00000576149, ENST00000401468, ENST00000574029,	ENST00000519528, ENST00000220959, ENST00000518205, ENST00000520539, ENST00000521922,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 15 X 14=3780	14 X 17 X 10=2380
	# samples	24	19
	** MAII score	log2(24/3780*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2380*10)=-3.64689024986436 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: VPS53 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	VPS53(526773)-UBR5(103277506), # samples:1
Anticipated loss of major functional domain due to fusion event.	VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UBR5	GO:0000209	protein polyubiquitination	21118991\|28689657
Tgene	UBR5	GO:0006974	cellular response to DNA damage stimulus	12011095
Tgene	UBR5	GO:0010628	positive regulation of gene expression	18076571
Tgene	UBR5	GO:0050847	progesterone receptor signaling pathway	12011095
Tgene	UBR5	GO:0070936	protein K48-linked ubiquitination	28689657

Fusion gene breakpoints across VPS53 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-IN-8462-11A	VPS53	chr17	526773	-	UBR5	chr8	103277506	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000437048	VPS53	chr17	526773	-	ENST00000520539	UBR5	chr8	103277506	-	3531	1263	147	2240	697
ENST00000437048	VPS53	chr17	526773	-	ENST00000220959	UBR5	chr8	103277506	-	2804	1263	147	2237	696
ENST00000437048	VPS53	chr17	526773	-	ENST00000518205	UBR5	chr8	103277506	-	2342	1263	147	2237	696
ENST00000437048	VPS53	chr17	526773	-	ENST00000521922	UBR5	chr8	103277506	-	2342	1263	147	2237	696
ENST00000291074	VPS53	chr17	526773	-	ENST00000520539	UBR5	chr8	103277506	-	3431	1163	134	2140	668
ENST00000291074	VPS53	chr17	526773	-	ENST00000220959	UBR5	chr8	103277506	-	2704	1163	134	2137	667
ENST00000291074	VPS53	chr17	526773	-	ENST00000518205	UBR5	chr8	103277506	-	2242	1163	134	2137	667
ENST00000291074	VPS53	chr17	526773	-	ENST00000521922	UBR5	chr8	103277506	-	2242	1163	134	2137	667
ENST00000571805	VPS53	chr17	526773	-	ENST00000520539	UBR5	chr8	103277506	-	3521	1253	137	2230	697
ENST00000571805	VPS53	chr17	526773	-	ENST00000220959	UBR5	chr8	103277506	-	2794	1253	137	2227	696
ENST00000571805	VPS53	chr17	526773	-	ENST00000518205	UBR5	chr8	103277506	-	2332	1253	137	2227	696
ENST00000571805	VPS53	chr17	526773	-	ENST00000521922	UBR5	chr8	103277506	-	2332	1253	137	2227	696

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000437048	ENST00000520539	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.000734665	0.9992654
ENST00000437048	ENST00000220959	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.001998937	0.99800104
ENST00000437048	ENST00000518205	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.003831013	0.99616903
ENST00000437048	ENST00000521922	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.003831013	0.99616903
ENST00000291074	ENST00000520539	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.000394775	0.99960524
ENST00000291074	ENST00000220959	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.001279283	0.9987207
ENST00000291074	ENST00000518205	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.002598106	0.99740195
ENST00000291074	ENST00000521922	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.002598106	0.99740195
ENST00000571805	ENST00000520539	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.000732153	0.9992679
ENST00000571805	ENST00000220959	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.001975424	0.9980246
ENST00000571805	ENST00000518205	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.003782756	0.9962172
ENST00000571805	ENST00000521922	VPS53	chr17	526773	-	UBR5	chr8	103277506	-	0.003782756	0.9962172

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98493_98493_1_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000220959_length(amino acids)=667AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL
DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL
ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA
EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL

--------------------------------------------------------------

>98493_98493_2_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000518205_length(amino acids)=667AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL
DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL
ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA
EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL

--------------------------------------------------------------

>98493_98493_3_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000520539_length(amino acids)=668AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLQENRKRHGSSRSVVDMD
LDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQ
LILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLT
AEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQH

--------------------------------------------------------------

>98493_98493_4_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000521922_length(amino acids)=667AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL
DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL
ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA
EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL

--------------------------------------------------------------

>98493_98493_5_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000220959_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

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>98493_98493_6_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000518205_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------

>98493_98493_7_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000520539_length(amino acids)=697AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNR
HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHR
MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF

--------------------------------------------------------------

>98493_98493_8_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000521922_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------

>98493_98493_9_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000220959_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

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>98493_98493_10_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000518205_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

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>98493_98493_11_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000520539_length(amino acids)=697AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNR
HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHR
MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF

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>98493_98493_12_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000521922_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:526773/chr8:103277506)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VPS53

chr17:526773

chr8:103277506

ENST00000291074

97_138

343.0

671.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VPS53

chr17:526773

chr8:103277506

ENST00000437048

97_138

372.0

833.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VPS53

chr17:526773

chr8:103277506

ENST00000571805

97_138

372.0

700.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2489_2500

2474.0

2800.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2737_2757

2474.0

2800.0

Compositional bias

Note=Pro-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

1528_1537

2474.0

2800.0

Compositional bias

Note=Poly-Ser

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

1671_1681

2474.0

2800.0

Compositional bias

Note=Poly-Ser

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

1762_1768

2474.0

2800.0

Compositional bias

Note=Poly-Ala

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

1986_1997

2474.0

2800.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2036_2059

2474.0

2800.0

Compositional bias

Note=Pro-rich

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2329_2348

2474.0

2800.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2357_2366

2474.0

2800.0

Compositional bias

Note=Arg/Asp-rich (mixed charge)

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

940_945

2474.0

2800.0

Compositional bias

Note=Poly-Glu

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

980_985

2474.0

2800.0

Compositional bias

Note=Poly-Ser

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2377_2454

2474.0

2800.0

Domain

PABC

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

2462_2799

2474.0

2800.0

Domain

HECT

Tgene

UBR5

chr17:526773

chr8:103277506

ENST00000520539

1177_1245

2474.0

2800.0

Zinc finger

UBR-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
VPS53
UBR5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to VPS53-UBR5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to VPS53-UBR5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source