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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:XRCC5-ABCB4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: XRCC5-ABCB4
FusionPDB ID: 99760
FusionGDB2.0 ID: 99760
HgeneTgene
Gene symbol

XRCC5

ABCB4

Gene ID

7520

5244

Gene nameX-ray repair cross complementing 5ATP binding cassette subfamily B member 4
SynonymsKARP-1|KARP1|KU80|KUB2|Ku86|NFIVABC21|GBD1|ICP3|MDR2|MDR2/3|MDR3|PFIC-3|PGY3
Cytomap

2q35

7q21.12

Type of geneprotein-codingprotein-coding
DescriptionX-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKuphosphatidylcholine translocator ABCB4ATP-binding cassette sub-family B member 4ATP-binding cassette, sub-family B (MDR/TAP), member 4P-glycoprotein 3P-glycoprotein-3/multiple drug resistance-3multidrug resistance protein 3multiple drug resistance 3
Modification date2020031320200315
UniProtAcc.

P21439

Ensembl transtripts involved in fusion geneENST idsENST00000471649, ENST00000392132, 
ENST00000392133, 		ENST00000265723, 
ENST00000358400, ENST00000359206, 
ENST00000453593, ENST00000545634, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 7=9104 X 5 X 4=80
# samples 124
** MAII scorelog2(12/910*10)=-2.92283213947754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: XRCC5 [Title/Abstract] AND ABCB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)XRCC5(216997110)-ABCB4(87031618), # samples:1
Anticipated loss of major functional domain due to fusion event.XRCC5-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXRCC5

GO:0002218

activation of innate immune response

28712728

HgeneXRCC5

GO:0006303

double-strand break repair via nonhomologous end joining

26359349

HgeneXRCC5

GO:0045860

positive regulation of protein kinase activity

22504299

HgeneXRCC5

GO:0071480

cellular response to gamma radiation

26359349

TgeneABCB4

GO:0032376

positive regulation of cholesterol transport

17523162

TgeneABCB4

GO:0045332

phospholipid translocation

8898203

TgeneABCB4

GO:0055088

lipid homeostasis

17523162

TgeneABCB4

GO:0061092

positive regulation of phospholipid translocation

17523162

TgeneABCB4

GO:0099040

ceramide translocation

8898203

TgeneABCB4

GO:1903413

cellular response to bile acid

17523162

TgeneABCB4

GO:2001140

positive regulation of phospholipid transport

8898203


check buttonFusion gene breakpoints across XRCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10T-01AXRCC5chr2

216997110

+ABCB4chr7

87031618

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392133XRCC5chr2216997110+ENST00000358400ABCB4chr787031618-18321574711780569
ENST00000392133XRCC5chr2216997110+ENST00000265723ABCB4chr787031618-18281574711780569
ENST00000392132XRCC5chr2216997110+ENST00000358400ABCB4chr787031618-15111253561459467
ENST00000392132XRCC5chr2216997110+ENST00000265723ABCB4chr787031618-15071253561459467

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392133ENST00000358400XRCC5chr2216997110+ABCB4chr787031618-0.0022787490.99772125
ENST00000392133ENST00000265723XRCC5chr2216997110+ABCB4chr787031618-0.0023429120.99765706
ENST00000392132ENST00000358400XRCC5chr2216997110+ABCB4chr787031618-0.0005512360.9994487
ENST00000392132ENST00000265723XRCC5chr2216997110+ABCB4chr787031618-0.000567960.999432

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99760_99760_1_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392132_ABCB4_chr7_87031618_ENST00000265723_length(amino acids)=467AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ

--------------------------------------------------------------

>99760_99760_2_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392132_ABCB4_chr7_87031618_ENST00000358400_length(amino acids)=467AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ

--------------------------------------------------------------

>99760_99760_3_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392133_ABCB4_chr7_87031618_ENST00000265723_length(amino acids)=569AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV

--------------------------------------------------------------

>99760_99760_4_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392133_ABCB4_chr7_87031618_ENST00000358400_length(amino acids)=569AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:216997110/chr7:87031618)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCB4

P21439

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:17523162, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258, ECO:0000269|PubMed:7957936, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9366571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021138_165371.0733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223138_165371.0733.0RegionNote=Leucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021478_519371.0733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223478_519371.0733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021251_460371.0733.0DomainNote=Ku
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223251_460371.0733.0DomainNote=Ku
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021720_728371.0733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223720_728371.0733.0MotifNote=EEXXXDL motif
TgeneABCB4chr2:216997110chr7:87031618ENST0000026572326281034_12791218.01287.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628394_6301218.01287.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000265723262857_3591218.01287.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628711_9991218.01287.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000035840025271034_12791164.01233.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527394_6301164.01233.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000358400252757_3591164.01233.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527711_9991164.01233.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000035920626281034_12791211.01280.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628394_6301211.01280.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000359206262857_3591211.01280.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628711_9991211.01280.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000045359324261034_12791164.01233.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426394_6301164.01233.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000453593242657_3591164.01233.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426711_9991164.01233.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000054563425271034_12791211.01280.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527394_6301211.01280.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000545634252757_3591211.01280.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527711_9991211.01280.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000026572326281069_10761218.01287.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628429_4361218.01287.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000035840025271069_10761164.01233.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527429_4361164.01233.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000035920626281069_10761211.01280.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628429_4361211.01280.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000045359324261069_10761164.01233.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426429_4361164.01233.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000054563425271069_10761211.01280.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527429_4361211.01280.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628140_1881218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000026572326281_501218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628211_2171218.01287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628239_2961218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628319_3321218.01287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628355_7111218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628733_7551218.01287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000265723262874_1181218.01287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628777_8311218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628853_8531218.01287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628874_9331218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628957_9721218.01287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628995_12861218.01287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527140_1881164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000035840025271_501164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527211_2171164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527239_2961164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527319_3321164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527355_7111164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527733_7551164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000358400252774_1181164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527777_8311164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527853_8531164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527874_9331164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527957_9721164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527995_12861164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628140_1881211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000035920626281_501211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628211_2171211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628239_2961211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628319_3321211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628355_7111211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628733_7551211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000359206262874_1181211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628777_8311211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628853_8531211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628874_9331211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628957_9721211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628995_12861211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426140_1881164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000045359324261_501164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426211_2171164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426239_2961164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426319_3321164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426355_7111164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426733_7551164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000453593242674_1181164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426777_8311164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426853_8531164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426874_9331164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426957_9721164.01233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426995_12861164.01233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527140_1881211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000054563425271_501211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527211_2171211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527239_2961211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527319_3321211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527355_7111211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527733_7551211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000545634252774_1181211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527777_8311211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527853_8531211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527874_9331211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527957_9721211.01280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527995_12861211.01280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628119_1391218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628189_2101218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628218_2381218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628297_3181218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628333_3541218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000265723262851_731218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628712_7321218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628756_7761218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628832_8521218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628854_8731218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628934_9561218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628973_9941218.01287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527119_1391164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527189_2101164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527218_2381164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527297_3181164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527333_3541164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000358400252751_731164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527712_7321164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527756_7761164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527832_8521164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527854_8731164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527934_9561164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527973_9941164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628119_1391211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628189_2101211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628218_2381211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628297_3181211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628333_3541211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000359206262851_731211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628712_7321211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628756_7761211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628832_8521211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628854_8731211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628934_9561211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628973_9941211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426119_1391164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426189_2101164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426218_2381164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426297_3181164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426333_3541164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000453593242651_731164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426712_7321164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426756_7761164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426832_8521164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426854_8731164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426934_9561164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426973_9941164.01233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527119_1391211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527189_2101211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527218_2381211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527297_3181211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527333_3541211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000545634252751_731211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527712_7321211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527756_7761211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527832_8521211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527854_8731211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527934_9561211.01280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527973_9941211.01280.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
XRCC5
ABCB4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628625_6471218.01287.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527625_6471164.01233.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628625_6471211.01280.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426625_6471164.01233.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527625_6471211.01280.0HAX1


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Related Drugs to XRCC5-ABCB4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to XRCC5-ABCB4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource