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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TRAP1 (NCBI Gene ID:10131)

Gene Summary

Gene Summary

Gene Information	Gene Name: TRAP1
	Gene ID: 10131
	Gene Symbol	TRAP1
	Gene ID	10131
	Gene Name	TNF receptor associated protein 1
	Synonyms	HSP 75\|HSP75\|HSP90L\|TRAP-1
	Cytomap	16p13.3
	Type of Gene	protein-coding
	Description	heat shock protein 75 kDa, mitochondrialTNFR-associated protein 1testicular tissue protein Li 209tumor necrosis factor type 1 receptor-associated protein
	Modification date	20200313
	UniProtAcc	Q12931

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'TRAP1[title] AND translation [title] AND human.'

Gene	Title	PMID
TRAP1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000246957	3708793	3708866	Frame-shift
ENST00000246957	3712882	3712968	Frame-shift
ENST00000246957	3721722	3721792	Frame-shift
ENST00000246957	3722700	3722821	Frame-shift
ENST00000246957	3727498	3727659	Frame-shift
ENST00000246957	3729719	3729791	In-frame
ENST00000246957	3735996	3736137	In-frame
ENST00000246957	3740827	3740986	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000246957	3729719	3729791	2313	561	632	704	157	181
ENST00000246957	3735996	3736137	2313	420	560	704	110	157
ENST00000246957	3740827	3740986	2313	178	336	704	29	82

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q12931	29	82	1	59	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q12931	110	157	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
Q12931	29	82	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
Q12931	157	181	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
Q12931	110	157	119	119	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q12931	157	181	158	158	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q12931	157	181	171	171	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q12931	157	181	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q5XHZ0
Q12931	157	181	174	174	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q5XHZ0
Q12931	29	82	30	82	Alternative sequence	ID=VSP_055061;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q12931	29	82	53	53	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q12931	110	157	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	110	157	111	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	110	157	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	110	157	149	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	110	157	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	157	181	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	157	181	165	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K
Q12931	157	181	179	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F3K

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	TRAP1	2.03966343840993	0.00179363833740354
PRAD	TRAP1	-1.80392022500731	1.07845847709215e-06
LUAD	TRAP1	-1.87625108559362	5.46188198426923e-11
BRCA	TRAP1	-1.06380779579514	7.66115886908469e-07
LUSC	TRAP1	-3.45372314024462	8.03131069907519e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
HNSC	TRAP1	0.080423481	0.020606514

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TRAP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	TRAP1	HSPD1	0.806095697	1.72E-76
COAD	TSG	TRAP1	HSPD1	0.806095697	1.72E-76
DLBC	Cell metabolism gene	TRAP1	TOMM40	0.823366812	6.78E-13
THYM	Cell metabolism gene	TRAP1	NME2	0.821545787	4.60E-31
THYM	Cell metabolism gene	TRAP1	PYCRL	0.836771695	3.53E-33
THYM	TF	TRAP1	NME2	0.821545787	4.60E-31
UCS	Cell metabolism gene	TRAP1	NME2	0.821545787	4.60E-31
UCS	Cell metabolism gene	TRAP1	PYCRL	0.836771695	3.53E-33
UCS	TF	TRAP1	NME2	0.821545787	4.60E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	TRAP1	SDHC	-1.52840691496805	0.000213860534131527
KIRC	TRAP1	SF3B3	-2.08803468573903	0.000285669684800144
HNSC	TRAP1	HSPD1	-1.59453887978196	0.000299885096865183
HNSC	TRAP1	SDHB	-5.12872014006671	0.000352023011600978
KIRP	TRAP1	SF3B3	-3.09726252244998	0.000772962812334299
LUSC	TRAP1	SUGT1	-1.60068865953167	0.00188801965955652
LIHC	TRAP1	AHSA1	-1.72615353398641	0.00221270975997039
KICH	TRAP1	SDHC	-1.10524823939928	0.0027848482131958
LUSC	TRAP1	SDHB	-1.49864562677473	0.00544874388117211
CHOL	TRAP1	HSPD1	-1.75958114436608	0.0078125
CHOL	TRAP1	SF3B3	-3.88275194777757	0.0078125
LUAD	TRAP1	SDHB	-1.51151695452528	0.0197825515973911
STAD	TRAP1	SDHB	-1.81284145175548	0.0279771662317216
UCEC	TRAP1	CYCS	-2.81266000225107	0.03125
READ	TRAP1	SDHA	-4.34806314177228	0.03125
READ	TRAP1	SDHD	-2.8560583931641	0.03125
READ	TRAP1	SUGT1	2.10579759798728	0.03125
CHOL	TRAP1	AHSA1	-1.36106793751016	0.0390625
KIRP	TRAP1	SUGT1	1.13926418133893	0.0394268441013992
LUAD	TRAP1	SF3B3	-6.09200707558835	1.10656371043093e-09
KIRC	TRAP1	SDHD	-1.66582171713554	1.13694293675248e-12
THCA	TRAP1	SDHC	1.40135887023041	1.73868443332877e-06
KIRC	TRAP1	SDHB	-3.83169487360232	1.81720885548231e-11
KIRP	TRAP1	SDHB	-2.90126424917802	2.00234353542328e-08
LUAD	TRAP1	AHSA1	-2.58952440987595	2.13281101437522e-07
LUAD	TRAP1	SUGT1	-2.18000490498598	2.62128880710432e-05
STAD	TRAP1	SDHD	-2.74997902866966	2.66358256340027e-06
THCA	TRAP1	SDHD	-2.87171638846854	2.78096836888549e-09
KICH	TRAP1	CYCS	1.56563374350741	2.98023223876953e-07
KICH	TRAP1	SDHA	1.06559309009896	2.98023223876953e-07
COAD	TRAP1	SDHB	-1.83943839161897	2.98023223876954e-07
COAD	TRAP1	SDHA	-4.06823294258253	2.98023223876954e-08
COAD	TRAP1	SDHD	-1.68696357518675	2.98023223876954e-08
THCA	TRAP1	CYCS	1.97748704739574	3.03520282946109e-06
STAD	TRAP1	HSPD1	-1.76107966337221	3.25962901115418e-08
BRCA	TRAP1	AHSA1	-2.44132549455198	3.30135919357351e-12
LUAD	TRAP1	HSPD1	-4.07650103036032	3.996080695583e-11
LUAD	TRAP1	SDHA	-2.39554422079373	4.60050884813659e-08
BRCA	TRAP1	CYCS	-1.49929042625543	4.88583064086618e-16
LUAD	TRAP1	CYCS	-6.2492698502496	5.91982739853218e-07
KIRC	TRAP1	SDHC	-1.82002730146872	6.10702203899889e-12
KIRP	TRAP1	SDHD	-1.81785087580238	8.84756445884705e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TRAP1

RB1, TNFRSF1A, SF3A2, EXT2, EXT1, HGS, H2AFX, UBC, RYK, HDAC5, AI837181, RAD21, CUL3, CUL5, PSMC4, APP, WDHD1, VDAC2, VAMP2, TRAF3IP1, FN1, C1QBP, ESX1, TPM3, FBXO6, EIF4A1, EEF1G, EEF1A1, HSPA5, GAPDH, RPS19, RPL7A, EIF2AK4, FKBP5, MAGED2, OGFR, USP7, CDK4, PRKACB, CDK9, CDK5, CEP250, CEP72, LGALS3BP, NXF1, CUL7, OBSL1, CCDC8, DND1, ALDOA, ALDOC, COQ3, COX6B1, DUT, GLRX, IQGAP1, LTA4H, PRDX5, AK2, ASNS, CFL1, HSDL2, PCMT1, PKM, RPE, SOD1, UFM1, NTRK1, CRKL, MKNK2, KIF2A, PAX6, FAN1, DNAJC11, Ppp6r1, GAN, SNW1, CDC5L, PA2G4, SND1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, SF3A3, DNAJC8, PLS3, CPSF6, NANS, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CBS, COQ2, COX15, DLD, DLST, HSD17B10, PARK7, PDHA1, SOAT1, VDAC1, EDEM3, MCPH1, TES, CDK1, MAD2L1, CCNB1, PHOSPHO1, UBE2M, TNIP2, MAPK3, MAPK1, SDHA, SPDL1, RIPK4, ESR2, HEXIM1, LARP7, RUNX1, AGR2, WWOX, RECQL4, METTL14, KIAA1429, ATG16L1, RBX1, TMEM41B, NR2C2, UBQLN2, ZFYVE21, ENO2, GOT1, GSR, IDH1, OAT, OXCT1, PGD, AADAT, TXNRD2, TYK2, APEX1, TNFRSF10A, Dppa3, GSK3B, ANO7, BIRC3, BRD7, ARIH2, PLEKHA4, MAGEA3, PINK1, YAP1, TFCP2, ZC3H18, PRKD1, ACTB, HSPA9, SYTL4, E, nsp16, HSCB, NEK4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, PTGER4, ECT2, KIF14, KIF23, PRC1, ACAD9, AUH, MCUR1, CCDC90B, FASTKD5, RPUSD3, NDN, BRD4, BRAF, BKRF1, KDM4C, KDF1, AARS2, COX8A, SFXN1, AASS, ABCB10, ABCB7, ABHD10, ACAT1, ACO2, ACOT1, ACOT2, ACOT9, AFG3L2, AK4, ALAS1, ALDH1B1, ATAD3A, ATP5A1, ATP5B, ATPIF1, ATP5J2-PTCD1, ATP5F1, ATP5J, ATPAF1, BCKDHA, C17orf80, C8orf82, CARS2, CLPB, CLPP, CLPX, COQ5, COQ6, CORO7-PAM16, COX4I1, COX5B, DARS2, DBT, DHTKD1, DHX30, DNAJA3, EARS2, ECH1, ECI2, ECSIT, ELAC2, ERAL1, ETFA, FASTKD2, FECH, FLAD1, GFM1, GLRX5, GLS, GLUD1, GRPEL1, GRSF1, GTPBP10, GUF1, HADH, HADHA, HINT2, HSPE1, IARS2, IBA57, IDH3B, ISCU, KIAA0391, LARS2, LETM1, LONP1, LRPPRC, LYPLAL1, LYRM2, LYRM7, MDH2, ME2, MGME1, MMAB, RNMTL1, MRPL19, MRPL24, MRPL37, MRPL42, MRPL44, MRPL45, MRPL46, MRPS17, MRPS22, MRPS24, MRPS26, MRPS27, MRPS28, MRPS31, MRPS35, MRPS36, MRPS6, MRPS9, MTERF3, MTHFD1L, MTIF2, MTPAP, MTRF1L, NDUFA10, NDUFA6, NDUFAF1, NDUFAF2, NDUFAF4, NDUFAF5, NDUFAF7, NDUFS2, NDUFS3, NDUFS6, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NNT, NT5DC2, OGDH, OXA1L, PCK2, PDE12, PDK1, PDK3, PDPR, PHB, PHB2, PNPLA8, PNPT1, POLDIP2, POLG, POLRMT, PPA2, PPIF, PREPL, PTCD3, PTPMT1, PYCR1, PYCR2, QRSL1, RARS2, RPS3, RTN4IP1, ACN9, SHMT2, SLC30A9, SSBP1, STOML2, SUCLA2, SUPV3L1, TACO1, TARS2, THEM4, THG1L, TIMM44, TRMT1, TRMT10C, TRMT5, UQCRFS1, VARS2, VWA8, YARS2, DDX24, GARS, HSPD1, SLC25A5, SSR4, FXR1, WDR5, NAA40, ARSF, DYNC1H1, FNBP4, UBR5, ORF8, TMPRSS2, ORF10, ORF7b, PFKM, CNR2, NR3C1, DDX3X, SAMM50,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TRAP1	chr16	3716017	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRAP1	chr16	3716025	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3716366	CA	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3721754	G	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3721773	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3721802	A	AG	Insertion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3723046	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3724330	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3724352	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRAP1	chr16	3724365	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3724428	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3724451	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRAP1	chr16	3724465	G	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3726074	GG	CA	Indel	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3726094	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3726160	A	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3726365	CGGGCGGGGGGCGGGG	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3726454	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3727512	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3727537	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRAP1	chr16	3727609	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRAP1	chr16	3727630	A	AG	Duplication	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TRAP1	chr16	3729713	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3729714	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3729764	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3736085	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3736128	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3736147	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3738887	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3739066	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
TRAP1	chr16	3739074	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRAP1	chr16	3739144	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3740991	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRAP1	chr16	3767473	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRAP1	chr16	3767509	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TRAP1	CHOL	chr16	3729751	3729751	T	C	Missense_Mutation		3
TRAP1	UCEC	chr16	3729730	3729730	G	A	Missense_Mutation	p.S178L	3
TRAP1	CHOL	chr16	3729751	3729751	T	C	Missense_Mutation	p.N171S	3
TRAP1	BRCA	chr16	3729754	3729754	G	C	Missense_Mutation	p.S170C	3
TRAP1	PAAD	chr16	3740954	3740954	C	A	Missense_Mutation	p.A41S	3
TRAP1	LIHC	chr16	3716032	3716032	A	-	Frame_Shift_Del	p.F232fs	3
TRAP1	UCEC	chr16	3740897	3740897	T	C	Missense_Mutation	p.S60G	3
TRAP1	UCEC	chr16	3721754	3721754	G	A	Missense_Mutation	p.R402W	3
TRAP1	KIRP	chr16	3712967	3712967	G	A	Splice_Site	p.A570_splice	2
TRAP1	ESCA	chr16	3722755	3722755	G	T	Missense_Mutation	p.L371I	2
TRAP1	STAD	chr16	3736090	3736090	T	-	Frame_Shift_Del	p.L127fs	2
TRAP1	STAD	chr16	3716054	3716054	G	A	Missense_Mutation	p.A434V	2
TRAP1	KIRP	chr16	3712967	3712967	G	A	Silent		2
TRAP1	UCEC	chr16	3708826	3708826	C	T	Missense_Mutation	p.E661K	2
TRAP1	STAD	chr16	3724366	3724366	G	A	Missense_Mutation	p.R340C	2
TRAP1	STAD	chr16	3736128	3736128	G	A	Missense_Mutation	p.R114W	2
TRAP1	CESC	chr16	3722736	3722736	G	A	Missense_Mutation		2
TRAP1	HNSC	chr16	3736066	3736066	G	A	Silent	p.D134D	2
TRAP1	KIRP	chr16	3724481	3724481	C	A	Missense_Mutation		2
TRAP1	UCEC	chr16	3708861	3708861	G	A	Missense_Mutation	p.A649V	2
TRAP1	PAAD	chr16	3740954	3740954	C	A	Missense_Mutation		2
TRAP1	STAD	chr16	3740920	3740920	C	A	Missense_Mutation	p.S52I	2
TRAP1	PRAD	chr16	3713497	3713497	T	G	Missense_Mutation	p.K337Q	2
TRAP1	STAD	chr16	3712930	3712930	T	C	Missense_Mutation	p.M583V	2
TRAP1	UCEC	chr16	3713495	3713497	CTT	-	In_Frame_Del	p.K546in_frame_del	2
TRAP1	LIHC	chr16	3708188	3708188	G	-	Frame_Shift_Del	p.P477fs	2
TRAP1	STAD	chr16	3726065	3726065	C	A	Missense_Mutation	p.K262N	2
TRAP1	UCEC	chr16	3721734	3721734	G	A	Silent	p.S408	2
TRAP1	PAAD	chr16	3722703	3722703	C	T	Missense_Mutation	p.R388Q	2
TRAP1	UCEC	chr16	3724386	3724386	G	A	Missense_Mutation	p.T333M	2
TRAP1	LIHC	chr16	3716059	3716059	T	-	Frame_Shift_Del	p.K223fs	2
TRAP1	PAAD	chr16	3724437	3724437	C	T	Missense_Mutation	p.R316H	2
TRAP1	STAD	chr16	3713498	3713498	C	T	Silent	p.K545K	2
TRAP1	LIHC	chr16	3716009	3716009	C	T	Missense_Mutation		2
TRAP1	UCEC	chr16	3725388	3725388	C	T	Silent	p.T275	2
TRAP1	STAD	chr16	3740886	3740886	G	A	Silent	p.T63T	2
TRAP1	CESC	chr16	3708835	3708835	G	A	Missense_Mutation	p.R658C	2
TRAP1	LIHC	chr16	3739091	3739091	C	A	Missense_Mutation		2
TRAP1	SKCM	chr16	3725373	3725373	G	A	Silent	p.F71F	2
TRAP1	UCEC	chr16	3726052	3726052	C	T	Missense_Mutation	p.E267K	2
TRAP1	HNSC	chr16	3727627	3727627	C	A	Missense_Mutation		2
TRAP1	STAD	chr16	3740865	3740865	G	T	Silent	p.P70P	2
TRAP1	STAD	chr16	3708226	3708226	G	A	Silent		2
TRAP1	UCEC	chr16	3736106	3736106	C	A	Missense_Mutation	p.S121I	2
TRAP1	STAD	chr16	3739122	3739122	A	G	Silent	p.H88H	2
TRAP1	COAD	chr16	3708226	3708226	G	A	Silent	p.Y673Y	2
TRAP1	STAD	chr16	3724428	3724428	G	A	Missense_Mutation		2
TRAP1	BLCA	chr16	3739139	3739139	C	T	Splice_Site		2
TRAP1	STAD	chr16	3724368	3724368	A	T	Missense_Mutation	p.I339N	2
TRAP1	SKCM	chr16	3727657	3727657	G	T	Silent	p.A129A	1
TRAP1	DLBC	chr16	3724365	3724365	C	T	Missense_Mutation	p.R340H	1
TRAP1	LIHC	chr16	3713465	3713465	C	T	Silent	p.V556V	1
TRAP1	PAAD	chr16	3713514	3713514	C	T	Missense_Mutation		1
TRAP1	STAD	chr16	3724428	3724428	G	A	Missense_Mutation	p.A319V	1
TRAP1	BLCA	chr16	3724352	3724352	G	A	Silent		1
TRAP1	HNSC	chr16	3726128	3726128	G	A	Silent	p.I32I	1
TRAP1	PRAD	chr16	3729744	3729744	C	T	Silent	p.G173G	1
TRAP1	STAD	chr16	3716059	3716059	T	-	Frame_Shift_Del	p.D433fs	1
TRAP1	KIRP	chr16	3724472	3724472	C	A	Missense_Mutation		1
TRAP1	SKCM	chr16	3725373	3725373	G	A	Silent	p.F227F	1
TRAP1	UCEC	chr16	3713495	3713497	CTT	-	In_Frame_Del	p.K546del	1
TRAP1	LIHC	chr16	3716009	3716009	C	T	Missense_Mutation	p.R449Q	1
TRAP1	PAAD	chr16	3722703	3722703	C	T	Missense_Mutation		1
TRAP1	HNSC	chr16	3712055	3712055	G	A	Nonsense_Mutation	p.Q416*	1
TRAP1	PRAD	chr16	3736032	3736032	G	A	Nonsense_Mutation	p.Q146*	1
TRAP1	COAD	chr16	3708854	3708854	G	A	Silent	p.I651I	1
TRAP1	LIHC	chr16	3736090	3736090	T	-	Frame_Shift_Del	p.K126fs	1
TRAP1	SKCM	chr16	3712001	3712001	C	T	Missense_Mutation	p.E590K	1
TRAP1	ESCA	chr16	3722755	3722755	G	T	Missense_Mutation		1
TRAP1	LIHC	chr16	3716009	3716009	C	T	Missense_Mutation	p.R240Q	1
TRAP1	PAAD	chr16	3724437	3724437	C	T	Missense_Mutation		1
TRAP1	PRAD	chr16	3712941	3712941	G	A	Missense_Mutation	p.T370M	1
TRAP1	COAD	chr16	3714361	3714361	G	A	Missense_Mutation	p.R495C	1
TRAP1	LIHC	chr16	3713482	3713482	C	-	Frame_Shift_Del	p.E342fs	1
TRAP1	SKCM	chr16	3722817	3722817	G	A	Missense_Mutation	p.P141L	1
TRAP1	ESCA	chr16	3726074	3726074	G	A	Silent		1
TRAP1	LIHC	chr16	3739091	3739091	C	A	Missense_Mutation	p.D99Y	1
TRAP1	CESC	chr16	3716075	3716075	A	T	Missense_Mutation		1
TRAP1	HNSC	chr16	3722789	3722789	C	T	Silent	p.L150L	1
TRAP1	COAD	chr16	3714429	3714429	G	A	Missense_Mutation	p.S472F	1
TRAP1	KIRP	chr16	3736138	3736138	C	A	Splice_Site		1
TRAP1	LUAD	chr16	3725361	3725361	G	A	Silent	p.P75P	1
TRAP1	SKCM	chr16	3740953	3740953	G	A	Missense_Mutation	p.A41V	1
TRAP1	ESCA	chr16	3726074	3726074	G	A	Silent	p.S259S	1
TRAP1	PRAD	chr16	3727584	3727594	AGTAGAAACCC	-	Frame_Shift_Del	p.VGFYS203fs	1
TRAP1	STAD	chr16	3708226	3708226	G	A	Silent	p.Y464Y	1
TRAP1	CESC	chr16	3708835	3708835	G	A	Missense_Mutation		1
TRAP1	HNSC	chr16	3722789	3722789	C	T	Silent	p.L359L	1
TRAP1	COAD	chr16	3724381	3724381	C	T	Missense_Mutation	p.A335T	1
TRAP1	LIHC	chr16	3714320	3714320	T	C	Silent		1
TRAP1	LUAD	chr16	3724358	3724358	G	C	Missense_Mutation	p.I133M	1
TRAP1	SKCM	chr16	3714414	3714414	G	A	Missense_Mutation	p.S268F	1
TRAP1	HNSC	chr16	3722789	3722789	C	T	Silent		1
TRAP1	STAD	chr16	3727537	3727537	T	G	Silent	p.A222A	1
TRAP1	READ	chr16	3725373	3725373	G	A	Silent	p.F280F	1
TRAP1	STAD	chr16	3724428	3724428	G	A	Missense_Mutation	p.A110V	1
TRAP1	CESC	chr16	3716075	3716075	A	T	Missense_Mutation	p.I218N	1
TRAP1	HNSC	chr16	3726128	3726128	G	A	Silent	p.I241I	1
TRAP1	COAD	chr16	3725372	3725372	C	T	Missense_Mutation	p.V281I	1
TRAP1	LIHC	chr16	3713466	3713466	A	G	Missense_Mutation		1
TRAP1	LUAD	chr16	3740936	3740936	G	A	Nonsense_Mutation	p.R47*	1
TRAP1	SKCM	chr16	3727657	3727657	G	T	Silent	p.A182A	1
TRAP1	HNSC	chr16	3726128	3726128	G	A	Silent		1
TRAP1	SARC	chr16	3725327	3725327	G	T	Missense_Mutation		1
TRAP1	STAD	chr16	3714317	3714317	C	T	Silent	p.E509E	1
TRAP1	THYM	chr16	3714412	3714412	C	A	Missense_Mutation		1
TRAP1	CESC	chr16	3715983	3715983	G	A	Nonsense_Mutation		1
TRAP1	KIRC	chr16	3726076	3726076	A	G	Missense_Mutation	p.S259P	1
TRAP1	COAD	chr16	3736083	3736083	G	A	Missense_Mutation	p.H129Y	1
TRAP1	LUAD	chr16	3740882	3740882	C	T	Missense_Mutation	p.E65K	1
TRAP1	SKCM	chr16	3712001	3712001	C	T	Missense_Mutation	p.E434K	1
TRAP1	HNSC	chr16	3739110	3739110	G	A	Silent		1
TRAP1	PAAD	chr16	3724437	3724437	C	T	Missense_Mutation	p.R107H	1
TRAP1	SARC	chr16	3740861	3740861	G	T	Missense_Mutation		1
TRAP1	STAD	chr16	3725375	3725375	A	G	Missense_Mutation	p.F280L	1
TRAP1	THYM	chr16	3713453	3713453	C	T	Silent		1
TRAP1	KIRP	chr16	3712967	3712967	G	A	Silent	p.A570A	1
TRAP1	COAD	chr16	3736085	3736085	C	T	Missense_Mutation	p.R128H	1
TRAP1	LUAD	chr16	3724427	3724427	C	A	Silent	p.A110A	1
TRAP1	PAAD	chr16	3713514	3713514	C	T	Missense_Mutation	p.R331H	1
TRAP1	SARC	chr16	3708159	3708159	G	T	Missense_Mutation		1
TRAP1	STAD	chr16	3716059	3716059	T	-	Frame_Shift_Del	p.K432fs	1
TRAP1	CESC	chr16	3722736	3722736	G	A	Missense_Mutation	p.T377M	1
TRAP1	KIRP	chr16	3727498	3727498	C	G	Splice_Site	.	1
TRAP1	COAD	chr16	3740841	3740842	TG	-	Frame_Shift_Del	p.78_79del	1
TRAP1	LIHC	chr16	3712966	3712966	C	T	Missense_Mutation	p.A571T	1
TRAP1	LUAD	chr16	3725361	3725361	G	A	Silent	p.P284P	1
TRAP1	ACC	chr16	3722703	3722703	C	T	Missense_Mutation	p.R179Q	1
TRAP1	HNSC	chr16	3724418	3724418	G	A	Silent	p.H113H	1
TRAP1	PAAD	chr16	3713514	3713514	C	T	Missense_Mutation	p.R540H	1
TRAP1	KIRP	chr16	3712967	3712967	G	A	Silent	p.A517A	1
TRAP1	SARC	chr16	3712046	3712046	C	T	Missense_Mutation		1
TRAP1	STAD	chr16	3715978	3715978	C	A	Missense_Mutation		1
TRAP1	CESC	chr16	3715983	3715983	G	A	Nonsense_Mutation	p.Q458*	1
TRAP1	LIHC	chr16	3708188	3708188	G	-	Frame_Shift_Del	p.P686fs	1
TRAP1	OV	chr16	3653465	3653465	C	T	Missense_Mutation	p.D557N	1
TRAP1	HNSC	chr16	3739110	3739110	G	A	Silent	p.A92A	1
TRAP1	PRAD	chr16	3726121	3726121	C	A	Missense_Mutation	p.A244S	1

Copy number variation (CNV) of TRAP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TRAP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101731	STAD	TCGA-BR-6458	ADNP	chr20	49547362	-	TRAP1	chr16	3729791	-
101731	N/A	CB050054	CASC4	chr15	44676365	+	TRAP1	chr16	3715462	-
101731	BLCA	TCGA-GV-A3QI-01A	CREBBP	chr16	3841981	-	TRAP1	chr16	3740985	-
101731	BLCA	TCGA-GV-A3QI-01A	CREBBP	chr16	3841982	-	TRAP1	chr16	3740986	-
101731	BRCA	TCGA-AR-A1AR-01A	CREBBP	chr16	3929833	-	TRAP1	chr16	3740986	-
101731	BRCA	TCGA-B6-A0RE-01A	CREBBP	chr16	3817721	-	TRAP1	chr16	3716119	-
101731	ESCA	TCGA-LN-A49S	CREBBP	chr16	3929833	-	TRAP1	chr16	3739138	-
101731	HNSC	TCGA-CV-6948	CREBBP	chr16	3860604	-	TRAP1	chr16	3740986	-
101731	STAD	TCGA-CG-4441-01A	CREBBP	chr16	3900298	-	TRAP1	chr16	3740986	-
101731	N/A	AA640304	DNASE1	chr16	3707868	+	TRAP1	chr16	3729750	+
101731	N/A	DA379519	HNRNPH1	chr5	179050049	-	TRAP1	chr16	3728552	-
101731	N/A	BE728037	KIF13B	chr8	29037628	-	TRAP1	chr16	3713503	-
93760	BRCA	TCGA-E9-A1NE-01A	TRAP1	chr16	3721723	-	ADCY9	chr16	4029276	-
102007	LUSC	TCGA-43-8115-01A	TRAP1	chr16	3740828	-	CREBBP	chr16	3799684	-
93760	N/A	FN086938	TRAP1	chr16	3708048	-	HYDIN2	chr1	367084	+
93760	HNSC	TCGA-CR-7388	TRAP1	chr16	3711994	-	IGKC	chr2	89157198	-
93760	N/A	EC574554	TRAP1	chr16	3712009	-	PPP2R2C	chr4	6492733	-
93760	N/A	EC537079	TRAP1	chr16	3752492	+	SMAD7	chr18	46466844	+
101731	Non-Cancer	161N	ZNF264	chr19	57703314	+	TRAP1	chr16	3727659	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	TRAP1	0.000186829178401964	0.0052
LUAD	TRAP1	0.00218006238714819	0.059
KIRP	TRAP1	0.00236525800607437	0.061
SARC	TRAP1	0.00582557002765256	0.15
HNSC	TRAP1	0.0115192245818449	0.28
MESO	TRAP1	0.0223486553785845	0.51
LUSC	TRAP1	0.032239992147237	0.71
LAML	TRAP1	0.0337029795792951	0.71
PAAD	TRAP1	0.0485253032655707	0.97

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	TRAP1	0.00514758699829935	0.16
THCA	TRAP1	1.63677291222842e-05	0.00054
PRAD	TRAP1	0.0267894299904451	0.8
PAAD	TRAP1	0.0061412836563318	0.19

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024623	Malignant neoplasm of stomach	1	CTD_human
C0029408	Degenerative polyarthritis	1	CTD_human
C0086743	Osteoarthrosis Deformans	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
C1968949	Cakut	1	GENOMICS_ENGLAND
C4225671	VATER/VACTERL ASSOCIATION	1	GENOMICS_ENGLAND