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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TNIP1 (NCBI Gene ID:10318)

Gene Summary

Gene Summary

Gene Information	Gene Name: TNIP1
	Gene ID: 10318
	Gene Symbol	TNIP1
	Gene ID	10318
	Gene Name	TNFAIP3 interacting protein 1
	Synonyms	ABIN-1\|NAF1\|VAN\|nip40-1
	Cytomap	5q33.1
	Type of Gene	protein-coding
	Description	TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein
	Modification date	20200327
	UniProtAcc	Q15025

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNIP1	GO:0009101	glycoprotein biosynthetic process	9923610
Hgene	TNIP1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	16684768
Hgene	TNIP1	GO:0070373	negative regulation of ERK1 and ERK2 cascade	12220502
Hgene	TNIP1	GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade	20010814
Hgene	TNIP1	GO:1903003	positive regulation of protein deubiquitination	16684768

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TNIP1	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'TNIP1[title] AND translation [title] AND human.'

Gene	Title	PMID
TNIP1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000315050	150411847	150411944	Frame-shift
ENST00000521591	150411847	150411944	Frame-shift
ENST00000522226	150411847	150411944	Frame-shift
ENST00000315050	150413168	150413360	In-frame
ENST00000521591	150413168	150413360	In-frame
ENST00000522226	150413168	150413360	In-frame
ENST00000315050	150414562	150414628	In-frame
ENST00000521591	150414562	150414628	In-frame
ENST00000522226	150414562	150414628	In-frame
ENST00000315050	150422100	150422232	In-frame
ENST00000521591	150422100	150422232	In-frame
ENST00000522226	150422100	150422232	In-frame
ENST00000315050	150425421	150425511	In-frame
ENST00000521591	150425421	150425511	In-frame
ENST00000522226	150425421	150425511	In-frame
ENST00000315050	150429384	150429508	Frame-shift
ENST00000521591	150429384	150429508	Frame-shift
ENST00000522226	150429384	150429508	Frame-shift
ENST00000315050	150436326	150436518	In-frame
ENST00000521591	150436326	150436518	In-frame
ENST00000522226	150436326	150436518	In-frame
ENST00000315050	150439878	150439956	In-frame
ENST00000521591	150439878	150439956	In-frame
ENST00000522226	150439878	150439956	In-frame
ENST00000315050	150444520	150444692	3UTR-3CDS
ENST00000521591	150444520	150444692	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000522226	150413168	150413360	2255	1694	1885	636	529	593
ENST00000521591	150413168	150413360	2291	1819	2010	636	529	593
ENST00000315050	150413168	150413360	2802	1698	1889	636	529	593
ENST00000522226	150414562	150414628	2255	1628	1693	636	507	529
ENST00000521591	150414562	150414628	2291	1753	1818	636	507	529
ENST00000315050	150414562	150414628	2802	1632	1697	636	507	529
ENST00000522226	150422100	150422232	2255	1109	1240	636	334	378
ENST00000521591	150422100	150422232	2291	1234	1365	636	334	378
ENST00000315050	150422100	150422232	2802	1113	1244	636	334	378
ENST00000522226	150425421	150425511	2255	953	1042	636	282	312
ENST00000521591	150425421	150425511	2291	1078	1167	636	282	312
ENST00000315050	150425421	150425511	2802	957	1046	636	282	312
ENST00000522226	150436326	150436518	2255	542	733	636	145	209
ENST00000521591	150436326	150436518	2291	667	858	636	145	209
ENST00000315050	150436326	150436518	2802	546	737	636	145	209
ENST00000522226	150439878	150439956	2255	464	541	636	119	145
ENST00000521591	150439878	150439956	2291	589	666	636	119	145
ENST00000315050	150439878	150439956	2802	468	545	636	119	145

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	TNIP1	1.63240221966042	2.25998111659284e-12
COAD	TNIP1	-1.75311344049792	2.62260437011719e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	TNIP1	-0.065794253	0.017911051
CESC	TNIP1	0.057205265	0.037203142
MESO	TNIP1	0.053114008	0.044250874

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TNIP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
TGCT	TSG	TNIP1	NINJ1	0.809519368	1.90E-37
THYM	CGC	TNIP1	NFKBIE	0.810225356	1.29E-29
UCS	CGC	TNIP1	NFKBIE	0.810225356	1.29E-29
UVM	IUPHAR	TNIP1	GRK6	0.806972691	1.60E-19
UVM	Kinase	TNIP1	GRK6	0.806972691	1.60E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
HNSC	TNIP1	TNFAIP3	1.64074220449189	0.000154256683799759
KICH	TNIP1	TAX1BP1	1.11297193980327	0.000249803066253662
THCA	TNIP1	TNFAIP3	1.94461383489945	0.000636745843936335
PRAD	TNIP1	TNIP2	-1.59742929137297	0.0008447947014615
LIHC	TNIP1	TNF	1.16984272940281	0.00126327311470459
BLCA	TNIP1	UBC	-2.97103318406418	0.0016937255859375
KIRP	TNIP1	UBC	-2.2186083712878	0.00192895717918873
LIHC	TNIP1	SELPLG	1.50838433830753	0.0019437011899127
LUAD	TNIP1	TNFAIP3	-1.06406864365455	0.00222650507088145
LUAD	TNIP1	TNF	-2.02011959393159	0.00259726426174564
THCA	TNIP1	SELPLG	-1.80760182126587	0.00263087014408499
LIHC	TNIP1	IKBKG	1.44188849302489	0.00313782336931997
STAD	TNIP1	TNFRSF1A	-1.34810426591984	0.0044123362749815
COAD	TNIP1	TNIP2	-1.02298994936843	0.00468936562538148
PRAD	TNIP1	UBC	1.38340454972911	0.00482349779780149
CHOL	TNIP1	TNFRSF1A	-2.32949221836426	0.0078125
KICH	TNIP1	SELPLG	-1.21128430820309	0.0105108022689819
BLCA	TNIP1	TNFAIP3	-2.12798079795034	0.0108261108398438
KICH	TNIP1	TNF	1.12078167946604	0.0124664902687073
COAD	TNIP1	UBC	1.14829675978632	0.012952595949173
BRCA	TNIP1	UBC	-4.44331707162822	0.0160227796839167
THCA	TNIP1	TNF	1.3339466685595	0.0190962589608376
READ	TNIP1	IKBKG	-2.74727134405965	0.03125
STAD	TNIP1	NFKB1	1.09541864183969	0.0413399673998356
LUSC	TNIP1	TNF	-1.0646802690009	0.043385243245119
BRCA	TNIP1	TNF	-1.27744044781851	0.0492641947075503
COAD	TNIP1	OPTN	-2.93716390812365	1.59740447998047e-05
LIHC	TNIP1	TNFRSF1A	-1.44445834552448	2.15714149891596e-08
KICH	TNIP1	TNFRSF1A	1.24797164850066	2.66432762145996e-05
PRAD	TNIP1	OPTN	2.2848267059205	3.50294169507139e-08
LUAD	TNIP1	SELPLG	-1.33044658212677	3.996080695583e-11
LUSC	TNIP1	SELPLG	-5.01315307346797	7.13549502039471e-10
KIRP	TNIP1	IKBKG	-2.16641271643668	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TNIP1

TTF2, MAGEB18, TNFAIP3, MAPK1, Ikbkg, TNF, IKBKG, UBC, TAX1BP1, IKBKE, TBK1, TRAF3, RARA, RARG, NFKB1, MYD88, SELPLG, PIK3R1, PIK3CD, gag, RBFOX1, nef, RNF11, CCNG1, GIT2, OPTN, ADH6, CDKN1A, EFEMP1, FUS, GTF2H1, PIN1, MAPK10, SUMO2, TNIP1, RABAC1, NME7, BYSL, EHHADH, GTF2B, KIFC3, TCEA2, ZBTB25, AP1M1, MORF4L2, NDC80, ZNHIT1, RALBP1, MORF4L1, PNKP, GABARAPL2, FAM168A, GABARAPL1, VPS33B, MAGEH1, CDIP1, SNIP1, TNIP3, MAP1LC3B, FAM161A, NIFK, MAP1LC3A, MOB1B, TCEANC2, SYT6, MOB3C, CCDC112, TXLNA, CFAP53, HDDC3, MAP3K1, CRHBP, GRAP2, SSX2IP, OFD1, PCM1, CEP97, CEP152, CEP135, CEP44, FBF1, NINL, ODF2, CENPJ, MCM10, TYRO3, CCDC121, ABHD17A, XPO1, TRAF1, ABI2, IKBIP, PIGT, SYNC, SAMD4A, HAO2, POTEF, ERP44, NAB2, EXOC1, CORO6, YLR108C, ARO2, TAE1, HUA1, RAM2, NAT1, DOA4, PDCD6, SPATA2, NOD2, OPRM1, HDAC1, TRADD, FADD, TANK, TRAF2, RBCK1, RNF31, SHARPIN, TNIP2, UEVLD, ULK3, MLF1, CD82, NBR1, TENM3, SEMA4G, PLEKHB2, PJA2, MYH11, RNF115, UMAD1, CACNA2D2, MOXD1, PODXL2, EMILIN2, EIF3C, NID2, NDNF, COCH, HIST3H2BB, SET, SMOC1, TNFRSF1A, HAPLN3, LAMA4, SPOCK3, SULF2, BIRC2, PSMD14, TCEB3, TSG101, PIBF1, TTC39A, CDC23, CDC37, RNF8, DPPA4, ZMAT2, WTAP, LENG8, TCEANC, C8orf33, DAZAP2, KRTAP8-1, KRTAP6-1, KRTAP6-2, KRTAP19-5, KIAA1598, MCRS1, LITAF, CYSRT1, MAP1LC3C, KRTAP6-3, KRTAP19-3, KRTAP19-7, ORF3a, HSPA5, nsp12, nsp7, SDCCAG3, TNRC6C, UNK, LRRC61, AP2B1, KRT8, SQSTM1, STIL, SYNE3, VIM, FXR1, LURAP1, BRK1, BFSP1, NRSN1, ZC3H14, MDFI, DMD, DUSP16, PTX3, VPS28, TNNC2, FAM167A, GLMN, BTF3, N, ARRB2, CALCOCO2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TNIP1	chr5	150413202	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TNIP1	chr5	150413290	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
TNIP1	chr5	150429452	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TNIP1	chr5	150431799	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TNIP1	chr5	150436503	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TNIP1	chr5	150436516	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TNIP1	chr5	150436517	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TNIP1	BRCA	chr5	150439923	150439923	C	T	Missense_Mutation	p.E131K	5
TNIP1	KIRP	chr5	150444534	150444534	C	G	Silent	p.G41G	4
TNIP1	ESCA	chr5	150410284	150410284	C	G	Missense_Mutation	p.G634A	3
TNIP1	ESCA	chr5	150411870	150411870	G	A	Silent		3
TNIP1	UCS	chr5	150436454	150436454	G	A	Missense_Mutation	p.T167M	3
TNIP1	UCEC	chr5	150425460	150425460	C	T	Missense_Mutation	p.E300K	3
TNIP1	UCEC	chr5	150422142	150422142	G	A	Missense_Mutation	p.R365C	3
TNIP1	ESCA	chr5	150411870	150411870	G	A	Silent	p.P618P	3
TNIP1	SKCM	chr5	150436378	150436378	G	A	Silent	p.N192N	3
TNIP1	UCEC	chr5	150416376	150416376	G	A	Missense_Mutation	p.T457M	3
TNIP1	TGCT	chr5	150436337	150436337	G	T	Missense_Mutation	p.S206Y	2
TNIP1	SKCM	chr5	150416402	150416402	G	A	Silent	p.A448A	2
TNIP1	UCEC	chr5	150418783	150418783	C	T	Missense_Mutation	p.D380N	2
TNIP1	STAD	chr5	150410293	150410293	T	C	Missense_Mutation	p.D631G	2
TNIP1	ESCA	chr5	150411870	150411870	G	A	Silent	p.P618	2
TNIP1	STAD	chr5	150418747	150418747	G	A	Missense_Mutation	p.R392C	2
TNIP1	UCEC	chr5	150425499	150425499	C	T	Missense_Mutation	p.A287T	2
TNIP1	LIHC	chr5	150410296	150410296	T	-	Frame_Shift_Del	p.N630fs	2
TNIP1	STAD	chr5	150422141	150422141	C	T	Missense_Mutation	p.R365H	2
TNIP1	UCEC	chr5	150443195	150443195	C	T	Missense_Mutation	p.D84N	2
TNIP1	LIHC	chr5	150413180	150413180	G	-	Frame_Shift_Del	p.L590fs	2
TNIP1	LIHC	chr5	150436400	150436400	C	-	Frame_Shift_Del	p.G185fs	2
TNIP1	CHOL	chr5	150409654	150409654	G	A	Nonsense_Mutation		2
TNIP1	HNSC	chr5	150422486	150422486	G	A	Missense_Mutation	p.R325W	2
TNIP1	ESCA	chr5	150410286	150410286	C	A	Missense_Mutation	p.E633D	2
TNIP1	LUAD	chr5	150422465	150422465	C	T	Missense_Mutation	p.E332K	2
TNIP1	STAD	chr5	150436492	150436492	G	A	Silent	p.D154D	2
TNIP1	SARC	chr5	150413231	150413231	G	A	Missense_Mutation	p.P573S	2
TNIP1	UCEC	chr5	150444543	150444543	T	G	Missense_Mutation	p.K38N	2
TNIP1	LIHC	chr5	150444562	150444562	T	-	Frame_Shift_Del	p.N32fs	2
TNIP1	COAD	chr5	150410296	150410296	T	-	Frame_Shift_Del	p.M534fs	2
TNIP1	ESCA	chr5	150410288	150410288	C	G	Missense_Mutation	p.E633Q	2
TNIP1	HNSC	chr5	150422172	150422172	C	T	Missense_Mutation	p.E355K	2
TNIP1	SKCM	chr5	150436501	150436501	G	A	Silent	p.P151P	2
TNIP1	ESCA	chr5	150410284	150410284	C	G	Missense_Mutation		2
TNIP1	SKCM	chr5	150443209	150443209	G	A	Missense_Mutation	p.S79F	2
TNIP1	UVM	chr5	150411884	150411884	C	G	Missense_Mutation		2
TNIP1	COAD	chr5	150413227	150413227	G	-	Frame_Shift_Del	p.P574fs	2
TNIP1	ESCA	chr5	150443229	150443229	C	A	Silent		2
TNIP1	LIHC	chr5	150441768	150441768	C	A	Missense_Mutation		2
TNIP1	UVM	chr5	150411884	150411884	C	G	Missense_Mutation	p.V614L	2
TNIP1	HNSC	chr5	150422172	150422172	C	T	Missense_Mutation		2
TNIP1	ESCA	chr5	150443229	150443229	C	A	Silent	p.L72L	2
TNIP1	TGCT	chr5	150436337	150436337	G	T	Missense_Mutation		2
TNIP1	SKCM	chr5	150416401	150416401	G	A	Missense_Mutation	p.L449F	2
TNIP1	UCEC	chr5	150411857	150411857	T	C	Missense_Mutation	p.T623A	2
TNIP1	ESCA	chr5	150410288	150410288	C	G	Missense_Mutation		1
TNIP1	LIHC	chr5	150436496	150436496	T	C	Missense_Mutation	p.E153G	1
TNIP1	PRAD	chr5	150415234	150415234	C	T	Missense_Mutation	p.R477H	1
TNIP1	BLCA	chr5	150441747	150441747	G	C	Missense_Mutation	p.P100A	1
TNIP1	HNSC	chr5	150444653	150444653	C	T	Missense_Mutation		1
TNIP1	LIHC	chr5	150441727	150441727	G	-	Frame_Shift_Del	p.P106fs	1
TNIP1	PRAD	chr5	150444612	150444612	G	A	Silent	p.S15S	1
TNIP1	THCA	chr5	150411907	150411907	C	T	Missense_Mutation	p.R606Q	1
TNIP1	GBM	chr5	150422129	150422131	AGG	-	In_Frame_Del	p.368_369LL>L	1
TNIP1	LIHC	chr5	150441768	150441768	C	A	Missense_Mutation	p.D93Y	1
TNIP1	SKCM	chr5	150411874	150411874	G	A	Missense_Mutation	p.P617L	1
TNIP1	BLCA	chr5	150411896	150411896	G	T	Missense_Mutation	p.Q610K	1
TNIP1	HNSC	chr5	150444653	150444653	C	T	Missense_Mutation	p.E2K	1
TNIP1	KIRP	chr5	150444534	150444534	C	G	Silent		1
TNIP1	LUAD	chr5	150422188	150422188	C	T	Silent	p.V349V	1
TNIP1	PRAD	chr5	150422163	150422163	G	A	Nonsense_Mutation	p.Q358*	1
TNIP1	THYM	chr5	150413328	150413328	G	T	Missense_Mutation		1
TNIP1	GBM	chr5	150443308	150443308	C	A	Missense_Mutation		1
TNIP1	SKCM	chr5	150439957	150439957	C	A	Splice_Site		1
TNIP1	HNSC	chr5	150436431	150436431	G	A	Missense_Mutation	p.P175S	1
TNIP1	ESCA	chr5	150443229	150443229	C	A	Silent	p.L72	1
TNIP1	LGG	chr5	150444602	150444602	C	A	Nonsense_Mutation	p.G19*	1
TNIP1	LUAD	chr5	150444522	150444522	T	C	Splice_Site	p.L45_splice	1
TNIP1	SARC	chr5	150413231	150413231	G	A	Missense_Mutation		1
TNIP1	THYM	chr5	150411856	150411856	G	A	Missense_Mutation		1
TNIP1	GBM	chr5	150422220	150422220	G	A	Missense_Mutation		1
TNIP1	SKCM	chr5	150411944	150411944	G	A	Splice_Site	p.P594_splice	1
TNIP1	LGG	chr5	150425452	150425454	CTT	-	In_Frame_Del	p.K302del	1
TNIP1	THYM	chr5	150411856	150411856	G	A	Missense_Mutation	p.T623I	1
TNIP1	GBM	chr5	150443267	150443267	G	A	Missense_Mutation		1
TNIP1	SKCM	chr5	150436366	150436366	G	A	Silent	p.S196S	1
TNIP1	HNSC	chr5	150410275	150410275	C	G	Nonstop_Mutation	p.*637S	1
TNIP1	LGG	chr5	150444602	150444602	C	A	Nonsense_Mutation		1
TNIP1	LUAD	chr5	150429495	150429495	C	G	Missense_Mutation	p.E246Q	1
TNIP1	STAD	chr5	150411908	150411908	G	A	Nonsense_Mutation	p.R606*	1
TNIP1	SARC	chr5	150411841	150411841	G	A	RNA	NULL	1
TNIP1	THYM	chr5	150413348	150413348	G	A	Missense_Mutation	p.R534C	1
TNIP1	UCS	chr5	150436454	150436454	G	A	Missense_Mutation		1
TNIP1	HNSC	chr5	150425467	150425467	G	A	Silent		1
TNIP1	LIHC	chr5	150410250	150410250	G	-	Frame_Shift_Del	p.P550fs	1
TNIP1	SKCM	chr5	150410310	150410310	T	C	Splice_Site		1
TNIP1	COAD	chr5	150411907	150411907	C	T	Missense_Mutation	p.E612K	1
TNIP1	LIHC	chr5	150441713	150441713	G	T	Missense_Mutation		1
TNIP1	LUSC	chr5	150416412	150416412	C	A	Missense_Mutation	p.G445V	1
TNIP1	STAD	chr5	150422226	150422226	C	A	Nonsense_Mutation	p.E337*	1
TNIP1	THYM	chr5	150413328	150413328	G	T	Missense_Mutation	p.H540Q	1
TNIP1	BLCA	chr5	150422117	150422117	T	G	Missense_Mutation		1
TNIP1	HNSC	chr5	150413222	150413222	G	T	Missense_Mutation		1
TNIP1	LIHC	chr5	150414564	150414564	T	-	Splice_Site	p.K529_splice	1
TNIP1	SKCM	chr5	150413244	150413244	G	A	Silent	p.S568S	1
TNIP1	COAD	chr5	150413182	150413182	C	T	Missense_Mutation	p.R589H	1
TNIP1	HNSC	chr5	150436497	150436497	C	T	Missense_Mutation	p.E153K	1
TNIP1	LIHC	chr5	150441722	150441722	T	C	Missense_Mutation		1
TNIP1	LUSC	chr5	150436437	150436437	C	T	Missense_Mutation	p.E173K	1
TNIP1	STAD	chr5	150411891	150411891	G	T	Missense_Mutation	p.S611R	1
TNIP1	BLCA	chr5	150444592	150444592	G	A	Missense_Mutation		1
TNIP1	HNSC	chr5	150436431	150436431	G	A	Missense_Mutation		1
TNIP1	HNSC	chr5	150415257	150415257	G	A	Silent	p.F469F	1
TNIP1	LIHC	chr5	150411874	150411874	G	-	Frame_Shift_Del	p.P618fs	1
TNIP1	SKCM	chr5	150413312	150413312	C	G	Missense_Mutation	p.G546R	1
TNIP1	OV	chr5	150441739	150441739	G	C	Silent	p.A102A	1
TNIP1	STAD	chr5	150436498	150436498	A	G	Silent	p.R152R	1
TNIP1	SKCM	chr5	150411944	150411944	G	A	Missense_Mutation	p.P594S	1
TNIP1	UVM	chr5	150411884	150411884	C	G	Missense_Mutation	p.K619N	1
TNIP1	BLCA	chr5	150422465	150422465	C	T	Missense_Mutation		1
TNIP1	HNSC	chr5	150422486	150422486	G	A	Missense_Mutation		1
TNIP1	COAD	chr5	150415226	150415226	G	A	Missense_Mutation	p.R480C	1
TNIP1	KIRP	chr5	150443286	150443286	C	T	Silent	p.Q53Q	1
TNIP1	LIHC	chr5	150413203	150413203	G	-	Frame_Shift_Del	p.P584fs	1
TNIP1	SKCM	chr5	150411892	150411892	C	T	Missense_Mutation	p.S611N	1
TNIP1	LIHC	chr5	150410290	150410290	C	-	Frame_Shift_Del	p.R632fs	1
TNIP1	PRAD	chr5	150439883	150439883	G	A	Missense_Mutation	p.A144V	1
TNIP1	STAD	chr5	150411908	150411908	G	A	Nonsense_Mutation		1
TNIP1	BLCA	chr5	150422117	150422117	T	G	Missense_Mutation	p.K373T	1
TNIP1	COAD	chr5	150425467	150425467	G	A	Silent	p.G297G	1
TNIP1	KIRP	chr5	150443282	150443283	-	ATA	In_Frame_Ins	p.E55delinsYE	1
TNIP1	LIHC	chr5	150413286	150413286	G	-	Frame_Shift_Del	p.P554fs	1
TNIP1	STAD	chr5	150411908	150411908	G	A	Nonsense_Mutation	p.R606X	1
TNIP1	LIHC	chr5	150415262	150415262	T	C	Missense_Mutation	p.I468V	1
TNIP1	PRAD	chr5	150436423	150436423	G	A	Silent	p.H177H	1
TNIP1	BLCA	chr5	150444592	150444592	G	A	Missense_Mutation	p.S22F	1
TNIP1	HNSC	chr5	150436497	150436497	C	T	Missense_Mutation		1
TNIP1	DLBC	chr5	150441711	150441711	G	C	Missense_Mutation	p.P112A	1
TNIP1	KIRP	chr5	150443283	150443286	CATC	-	Frame_Shift_Del	p.54_55del	1
TNIP1	LIHC	chr5	150413330	150413330	G	-	Frame_Shift_Del	p.H540fs	1
TNIP1	STAD	chr5	150422226	150422226	C	A	Nonsense_Mutation	p.E337X	1

Copy number variation (CNV) of TNIP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TNIP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
22783	N/A	CB048687	DIAPH3	chr13	60566981	-	TNIP1	chr5	150409510	+
92714	KIRC	TCGA-A3-3352-01A	TNIP1	chr5	150422457	-	ANXA6	chr5	150503928	-
92714	LIHC	TCGA-DD-A3A1-01A	TNIP1	chr5	150466646	-	ANXA6	chr5	150503928	-
92714	UCEC	TCGA-AX-A3FX-01A	TNIP1	chr5	150418658	-	ANXA6	chr5	150497398	-
92714	KIRC	TCGA-BP-4965-01A	TNIP1	chr5	150439879	-	ARSI	chr5	149678175	-
94930	KIRC	TCGA-BP-4965-01A	TNIP1	chr5	150439879	-	CAMK2A	chr5	149669286	-
101610	STAD	TCGA-CD-5813-01A	TNIP1	chr5	150460441	-	G3BP1	chr5	151166133	+
92714	KIRC	TCGA-BP-4986-01A	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
92714	N/A	AI695817	TNIP1	chr5	150420672	+	SERHL	chr22	42906938	+
92714	SARC	TCGA-X6-A7WC-01A	TNIP1	chr5	150418658	-	SGCD	chr5	155550866	+
98567	KIRC	TCGA-BP-4965-01A	TNIP1	chr5	150439879	-	TCOF1	chr5	149762625	+
98632	N/A	AA368174	TNIP1	chr5	150409573	+	VIM	chr10	17271771	+
100829	N/A	BG272741	TNIP1	chr5	150409510	-	ZDHHC4	chr7	6622050	-
92714	Non-Cancer	5263N	TNIP1	chr5	150411847	-	ZWILCH	chr15	66820194	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	TNIP1	0.000592223003729502	0.016
LIHC	TNIP1	5.02503574486705e-05	0.0014

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TNIP1	0.000558151858853248	0.018
LUAD	TNIP1	0.00240688399546132	0.077
THCA	TNIP1	0.019899883005197	0.62
UCS	TNIP1	0.036542735330909	1
SARC	TNIP1	0.0281654781659173	0.82
DLBC	TNIP1	0.0205148696492044	0.62

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024141	Lupus Erythematosus, Systemic	7	CTD_human;ORPHANET
C0030246	Pustulosis of Palms and Soles	2	CTD_human
C0033860	Psoriasis	2	CTD_human
C0242380	Libman-Sacks Disease	2	CTD_human
C0004096	Asthma	1	CTD_human
C0006142	Malignant neoplasm of breast	1	CTD_human
C0036421	Systemic Scleroderma	1	CTD_human
C0086981	Sicca Syndrome	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C1527336	Sjogren's Syndrome	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human