Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ASCC3 (NCBI Gene ID:10973)

Gene Summary

Gene Summary

Gene Information	Gene Name: ASCC3
	Gene ID: 10973
	Gene Symbol	ASCC3
	Gene ID	10973
	Gene Name	activating signal cointegrator 1 complex subunit 3
	Synonyms	ASC1p200\|HELIC1\|RNAH
	Cytomap	6q16.3
	Type of Gene	protein-coding
	Description	activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
	Modification date	20200313
	UniProtAcc	Q8N3C0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASCC3	GO:0006307	DNA dealkylation involved in DNA repair	22055184
Hgene	ASCC3	GO:0032508	DNA duplex unwinding	22055184

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ASCC3	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'ASCC3[title] AND translation [title] AND human.'

Gene	Title	PMID
ASCC3	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000369162	100988038	100988263	In-frame
ENST00000369162	101098413	101098590	In-frame
ENST00000369162	101173414	101173579	In-frame
ENST00000369162	101246588	101246714	In-frame
ENST00000369162	101296023	101296583	Frame-shift
ENST00000369162	101311939	101312090	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000369162	100988038	100988263	8163	5896	6120	2202	1850	1925
ENST00000369162	101098413	101098590	8163	3421	3597	2202	1025	1084
ENST00000369162	101173414	101173579	8163	2083	2247	2202	579	634
ENST00000369162	101246588	101246714	8163	1615	1740	2202	423	465

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q8N3C0	579	634	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
Q8N3C0	1850	1925	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
Q8N3C0	1025	1084	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
Q8N3C0	423	465	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
Q8N3C0	579	634	486	669	Domain	Note=Helicase ATP-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q8N3C0	1025	1084	978	1287	Domain	Note=SEC63 1
Q8N3C0	1850	1925	1812	2176	Domain	Note=SEC63 2
Q8N3C0	579	634	611	614	Motif	Note=DEVH box
Q8N3C0	579	634	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
Q8N3C0	1850	1925	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
Q8N3C0	1025	1084	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
Q8N3C0	423	465	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
Q8N3C0	1850	1925	732	2202	Alternative sequence	ID=VSP_042958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8N3C0	1025	1084	732	2202	Alternative sequence	ID=VSP_042958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8N3C0	1025	1084	1050	1050	Natural variant	ID=VAR_034860;Note=V->I;Dbxref=dbSNP:rs9497983
Q8N3C0	423	465	444	444	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8N3C0	579	634	582	582	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	ASCC3	2.18518498783614	0.009765625
KIRP	ASCC3	-5.24180349883123	4.97791916131974e-07
BRCA	ASCC3	2.06358786352366	7.50752312589849e-07
THCA	ASCC3	-2.23628356566653	8.91332468972732e-06

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	ASCC3	-0.085846993	0.002366129
OV	ASCC3	-0.063683251	0.007478496
KIRC	ASCC3	0.02237996	0.037586956

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with ASCC3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
PRAD	CGC	ASCC3	PTPRK	0.800417252	6.83E-124
PRAD	CGC	ASCC3	GOPC	0.807948421	5.62E-128
PRAD	Epifactor	ASCC3	MAP3K7	0.856885141	8.01E-160
PRAD	IUPHAR	ASCC3	PTPRK	0.800417252	6.83E-124
PRAD	IUPHAR	ASCC3	MAP3K7	0.856885141	8.01E-160
PRAD	Kinase	ASCC3	MAP3K7	0.856885141	8.01E-160
PRAD	TSG	ASCC3	PTPRK	0.800417252	6.83E-124
PRAD	TSG	ASCC3	HACE1	0.82314522	8.48E-137
THCA	Cell metabolism gene	ASCC3	IQGAP1	0.80226462	8.15E-130
THCA	IUPHAR	ASCC3	TNFRSF10A	0.807193226	1.33E-132
THCA	TSG	ASCC3	TNFRSF10A	0.807193226	1.33E-132
THYM	Cell metabolism gene	ASCC3	PDPR	0.801103486	1.61E-28
THYM	Cell metabolism gene	ASCC3	NEU3	0.801330523	1.51E-28
THYM	Cell metabolism gene	ASCC3	ARFGEF2	0.804123165	7.07E-29
THYM	Cell metabolism gene	ASCC3	AASDHPPT	0.807411477	2.84E-29
THYM	Cell metabolism gene	ASCC3	PIKFYVE	0.808916519	1.86E-29
THYM	Cell metabolism gene	ASCC3	EP300	0.809747036	1.47E-29
THYM	Cell metabolism gene	ASCC3	PI4K2B	0.811127653	9.94E-30
THYM	Cell metabolism gene	ASCC3	ACER2	0.813753748	4.67E-30
THYM	Cell metabolism gene	ASCC3	PIK3R4	0.815746542	2.61E-30
THYM	Cell metabolism gene	ASCC3	UGCG	0.816847993	1.89E-30
THYM	Cell metabolism gene	ASCC3	SEC24B	0.817527778	1.54E-30
THYM	Cell metabolism gene	ASCC3	RQCD1	0.819970575	7.42E-31
THYM	Cell metabolism gene	ASCC3	POLR2B	0.820048246	7.25E-31
THYM	Cell metabolism gene	ASCC3	MED23	0.821126459	5.23E-31
THYM	Cell metabolism gene	ASCC3	NCOA2	0.822121216	3.86E-31
THYM	Cell metabolism gene	ASCC3	RANBP2	0.826176763	1.10E-31
THYM	Cell metabolism gene	ASCC3	PAFAH1B2	0.826883208	8.82E-32
THYM	Cell metabolism gene	ASCC3	CDK8	0.827001911	8.49E-32
THYM	Cell metabolism gene	ASCC3	PHAX	0.82715482	8.09E-32
THYM	Cell metabolism gene	ASCC3	GLS	0.830008702	3.26E-32
THYM	Cell metabolism gene	ASCC3	MUT	0.832216386	1.60E-32
THYM	Cell metabolism gene	ASCC3	NCOA6	0.841870172	6.18E-34
THYM	Cell metabolism gene	ASCC3	PATL1	0.842490654	4.98E-34
THYM	Cell metabolism gene	ASCC3	MED1	0.843957735	2.97E-34
THYM	Cell metabolism gene	ASCC3	SMG1	0.844410235	2.53E-34
THYM	Cell metabolism gene	ASCC3	NCOR1	0.847844476	7.39E-35
THYM	Cell metabolism gene	ASCC3	SEC24D	0.849581937	3.92E-35
THYM	Cell metabolism gene	ASCC3	GLUD2	0.853132683	1.04E-35
THYM	Cell metabolism gene	ASCC3	PIK3CA	0.853184075	1.02E-35
THYM	Cell metabolism gene	ASCC3	SYNJ2	0.862010605	3.27E-37
THYM	Cell metabolism gene	ASCC3	UPF2	0.880028611	1.29E-40
THYM	Cell metabolism gene	ASCC3	MANEA	0.880033959	1.29E-40
THYM	Cell metabolism gene	ASCC3	NUP153	0.898180316	1.20E-44
THYM	CGC	ASCC3	CREB1	0.802954156	9.73E-29
THYM	CGC	ASCC3	BRD4	0.803048132	9.48E-29
THYM	CGC	ASCC3	EP300	0.809747036	1.47E-29
THYM	CGC	ASCC3	PPM1D	0.810120689	1.32E-29
THYM	CGC	ASCC3	CHD2	0.810620579	1.15E-29
THYM	CGC	ASCC3	UBR5	0.816292926	2.22E-30
THYM	CGC	ASCC3	NUP98	0.82109416	5.28E-31
THYM	CGC	ASCC3	NCOA2	0.822121216	3.86E-31
THYM	CGC	ASCC3	TRRAP	0.82441144	1.91E-31
THYM	CGC	ASCC3	VHL	0.826049953	1.15E-31
THYM	CGC	ASCC3	RANBP2	0.826176763	1.10E-31
THYM	CGC	ASCC3	PAFAH1B2	0.826883208	8.82E-32
THYM	CGC	ASCC3	ATRX	0.828154071	5.90E-32
THYM	CGC	ASCC3	NSD1	0.83500416	6.38E-33
THYM	CGC	ASCC3	SPEN	0.835576277	5.27E-33
THYM	CGC	ASCC3	GOPC	0.838206111	2.18E-33
THYM	CGC	ASCC3	STRN	0.842391393	5.15E-34
THYM	CGC	ASCC3	MLLT10	0.84752733	8.30E-35
THYM	CGC	ASCC3	MAPK1	0.847588702	8.11E-35
THYM	CGC	ASCC3	NCOR1	0.847844476	7.39E-35
THYM	CGC	ASCC3	PTPN11	0.849547152	3.97E-35
THYM	CGC	ASCC3	LATS1	0.851434851	1.97E-35
THYM	CGC	ASCC3	PIK3CA	0.853184075	1.02E-35
THYM	CGC	ASCC3	N4BP2	0.859006635	1.08E-36
THYM	CGC	ASCC3	BARD1	0.86608003	6.16E-38
THYM	CGC	ASCC3	FUBP1	0.873772193	2.25E-39
THYM	CGC	ASCC3	ARID1B	0.874415435	1.69E-39
THYM	CGC	ASCC3	BIRC6	0.887560658	3.32E-42
THYM	CGC	ASCC3	BCLAF1	0.900940669	2.50E-45
THYM	CGC	ASCC3	STAG1	0.903487768	5.66E-46
THYM	Epifactor	ASCC3	USP12	0.800551808	1.86E-28
THYM	Epifactor	ASCC3	BRD4	0.803048132	9.48E-29
THYM	Epifactor	ASCC3	GTF2I	0.80461479	6.17E-29
THYM	Epifactor	ASCC3	PHC3	0.805471407	4.87E-29
THYM	Epifactor	ASCC3	CTR9	0.805589316	4.72E-29
THYM	Epifactor	ASCC3	SIRT1	0.807930679	2.46E-29
THYM	Epifactor	ASCC3	EP300	0.809747036	1.47E-29
THYM	Epifactor	ASCC3	TAF1L	0.810131458	1.32E-29
THYM	Epifactor	ASCC3	RLIM	0.810304695	1.26E-29
THYM	Epifactor	ASCC3	CHD2	0.810620579	1.15E-29
THYM	Epifactor	ASCC3	SMEK2	0.810905773	1.06E-29
THYM	Epifactor	ASCC3	ZNF217	0.811156703	9.86E-30
THYM	Epifactor	ASCC3	ZZZ3	0.812851228	6.06E-30
THYM	Epifactor	ASCC3	UBR5	0.816292926	2.22E-30
THYM	Epifactor	ASCC3	NCOA2	0.822121216	3.86E-31
THYM	Epifactor	ASCC3	RBBP5	0.823971952	2.19E-31
THYM	Epifactor	ASCC3	KDM3B	0.824222279	2.02E-31
THYM	Epifactor	ASCC3	TRRAP	0.82441144	1.91E-31
THYM	Epifactor	ASCC3	JMJD1C	0.825046658	1.57E-31
THYM	Epifactor	ASCC3	TAF1	0.825161847	1.51E-31
THYM	Epifactor	ASCC3	MPHOSPH8	0.827040494	8.39E-32
THYM	Epifactor	ASCC3	UBR2	0.827076611	8.30E-32
THYM	Epifactor	ASCC3	RNF168	0.827628205	6.97E-32
THYM	Epifactor	ASCC3	ATRX	0.828154071	5.90E-32
THYM	Epifactor	ASCC3	TADA2A	0.831303547	2.15E-32
THYM	Epifactor	ASCC3	NSD1	0.83500416	6.38E-33
THYM	Epifactor	ASCC3	SPEN	0.835576277	5.27E-33
THYM	Epifactor	ASCC3	ADNP	0.836733343	3.58E-33
THYM	Epifactor	ASCC3	NCOA6	0.841870172	6.18E-34
THYM	Epifactor	ASCC3	RSF1	0.842957664	4.23E-34
THYM	Epifactor	ASCC3	PHF8	0.843146356	3.96E-34
THYM	Epifactor	ASCC3	EPC2	0.847432707	8.59E-35
THYM	Epifactor	ASCC3	MLLT10	0.84752733	8.30E-35
THYM	Epifactor	ASCC3	TET3	0.847828217	7.44E-35
THYM	Epifactor	ASCC3	NCOR1	0.847844476	7.39E-35
THYM	Epifactor	ASCC3	SMARCAD1	0.848080053	6.79E-35
THYM	Epifactor	ASCC3	TAF2	0.848275504	6.32E-35
THYM	Epifactor	ASCC3	C11orf30	0.851055918	2.27E-35
THYM	Epifactor	ASCC3	EPC1	0.852712918	1.22E-35
THYM	Epifactor	ASCC3	DDX21	0.853000843	1.10E-35
THYM	Epifactor	ASCC3	BRPF3	0.853030883	1.09E-35
THYM	Epifactor	ASCC3	PPP4R2	0.858722991	1.21E-36
THYM	Epifactor	ASCC3	ZRANB3	0.86297208	2.21E-37
THYM	Epifactor	ASCC3	MGA	0.865379358	8.24E-38
THYM	Epifactor	ASCC3	BARD1	0.86608003	6.16E-38
THYM	Epifactor	ASCC3	SHPRH	0.869466172	1.47E-38
THYM	Epifactor	ASCC3	REST	0.871173313	7.04E-39
THYM	Epifactor	ASCC3	MAP3K7	0.871661079	5.69E-39
THYM	Epifactor	ASCC3	ARID1B	0.874415435	1.69E-39
THYM	Epifactor	ASCC3	ATF2	0.87451995	1.61E-39
THYM	Epifactor	ASCC3	BPTF	0.876511684	6.55E-40
THYM	Epifactor	ASCC3	SMARCA5	0.882985968	3.16E-41
THYM	IUPHAR	ASCC3	ATP13A3	0.801067295	1.62E-28
THYM	IUPHAR	ASCC3	ERN1	0.80280484	1.01E-28
THYM	IUPHAR	ASCC3	BRD4	0.803048132	9.48E-29
THYM	IUPHAR	ASCC3	NEK1	0.806114175	4.08E-29
THYM	IUPHAR	ASCC3	NEK4	0.80637335	3.80E-29
THYM	IUPHAR	ASCC3	SIRT1	0.807930679	2.46E-29
THYM	IUPHAR	ASCC3	PIKFYVE	0.808916519	1.86E-29
THYM	IUPHAR	ASCC3	EP300	0.809747036	1.47E-29
THYM	IUPHAR	ASCC3	PPM1D	0.810120689	1.32E-29
THYM	IUPHAR	ASCC3	TAF1L	0.810131458	1.32E-29
THYM	IUPHAR	ASCC3	PI4K2B	0.811127653	9.94E-30
THYM	IUPHAR	ASCC3	SLC30A5	0.811885857	8.00E-30
THYM	IUPHAR	ASCC3	TMEM30A	0.813147579	5.56E-30
THYM	IUPHAR	ASCC3	ACER2	0.813753748	4.67E-30
THYM	IUPHAR	ASCC3	PDPK1	0.815341977	2.94E-30
THYM	IUPHAR	ASCC3	SLC25A40	0.815423074	2.87E-30
THYM	IUPHAR	ASCC3	PIK3R4	0.815746542	2.61E-30
THYM	IUPHAR	ASCC3	UGCG	0.816847993	1.89E-30
THYM	IUPHAR	ASCC3	SLC39A10	0.817006978	1.80E-30
THYM	IUPHAR	ASCC3	SLC38A7	0.819414319	8.77E-31
THYM	IUPHAR	ASCC3	NCOA2	0.822121216	3.86E-31
THYM	IUPHAR	ASCC3	KDM3B	0.824222279	2.02E-31
THYM	IUPHAR	ASCC3	TRRAP	0.82441144	1.91E-31
THYM	IUPHAR	ASCC3	SLC25A24	0.824729046	1.73E-31
THYM	IUPHAR	ASCC3	JMJD1C	0.825046658	1.57E-31
THYM	IUPHAR	ASCC3	TAF1	0.825161847	1.51E-31
THYM	IUPHAR	ASCC3	SLC10A7	0.825642173	1.30E-31
THYM	IUPHAR	ASCC3	CDK8	0.827001911	8.49E-32
THYM	IUPHAR	ASCC3	SLC35A3	0.829303873	4.09E-32
THYM	IUPHAR	ASCC3	SLK	0.829709813	3.59E-32
THYM	IUPHAR	ASCC3	GLS	0.830008702	3.26E-32
THYM	IUPHAR	ASCC3	HIPK3	0.833451101	1.07E-32
THYM	IUPHAR	ASCC3	NSD1	0.83500416	6.38E-33
THYM	IUPHAR	ASCC3	TNKS	0.83862545	1.89E-33
THYM	IUPHAR	ASCC3	PHF8	0.843146356	3.96E-34
THYM	IUPHAR	ASCC3	SMG1	0.844410235	2.53E-34
THYM	IUPHAR	ASCC3	DPP8	0.847355881	8.83E-35
THYM	IUPHAR	ASCC3	MAPK1	0.847588702	8.11E-35
THYM	IUPHAR	ASCC3	TNKS2	0.85135301	2.04E-35
THYM	IUPHAR	ASCC3	LATS1	0.851434851	1.97E-35
THYM	IUPHAR	ASCC3	NR2C2	0.85278662	1.19E-35
THYM	IUPHAR	ASCC3	BRPF3	0.853030883	1.09E-35
THYM	IUPHAR	ASCC3	PIK3CA	0.853184075	1.02E-35
THYM	IUPHAR	ASCC3	ADAM17	0.856924902	2.45E-36
THYM	IUPHAR	ASCC3	SENP6	0.858469265	1.34E-36
THYM	IUPHAR	ASCC3	SYNJ2	0.862010605	3.27E-37
THYM	IUPHAR	ASCC3	SCYL2	0.862800354	2.37E-37
THYM	IUPHAR	ASCC3	MAP3K7	0.871661079	5.69E-39
THYM	IUPHAR	ASCC3	MAPK8	0.872364033	4.18E-39
THYM	IUPHAR	ASCC3	BPTF	0.876511684	6.55E-40
THYM	IUPHAR	ASCC3	ADAM10	0.876888863	5.52E-40
THYM	IUPHAR	ASCC3	BIRC6	0.887560658	3.32E-42
THYM	Kinase	ASCC3	ERN1	0.80280484	1.01E-28
THYM	Kinase	ASCC3	BRD4	0.803048132	9.48E-29
THYM	Kinase	ASCC3	NEK1	0.806114175	4.08E-29
THYM	Kinase	ASCC3	NEK4	0.80637335	3.80E-29
THYM	Kinase	ASCC3	TAF1L	0.810131458	1.32E-29
THYM	Kinase	ASCC3	PDPK1	0.815341977	2.94E-30
THYM	Kinase	ASCC3	PIK3R4	0.815746542	2.61E-30
THYM	Kinase	ASCC3	TRRAP	0.82441144	1.91E-31
THYM	Kinase	ASCC3	TAF1	0.825161847	1.51E-31
THYM	Kinase	ASCC3	CDK8	0.827001911	8.49E-32
THYM	Kinase	ASCC3	SLK	0.829709813	3.59E-32
THYM	Kinase	ASCC3	HIPK3	0.833451101	1.07E-32
THYM	Kinase	ASCC3	SMG1	0.844410235	2.53E-34
THYM	Kinase	ASCC3	MAPK1	0.847588702	8.11E-35
THYM	Kinase	ASCC3	LATS1	0.851434851	1.97E-35
THYM	Kinase	ASCC3	SCYL2	0.862800354	2.37E-37
THYM	Kinase	ASCC3	MAP3K7	0.871661079	5.69E-39
THYM	Kinase	ASCC3	MAPK8	0.872364033	4.18E-39
THYM	TF	ASCC3	ZNF543	0.802756013	1.03E-28
THYM	TF	ASCC3	CREB1	0.802954156	9.73E-29
THYM	TF	ASCC3	ZNF91	0.804533486	6.31E-29
THYM	TF	ASCC3	GTF2I	0.80461479	6.17E-29
THYM	TF	ASCC3	ZFP91	0.804940123	5.64E-29
THYM	TF	ASCC3	ZNF689	0.807223376	3.00E-29
THYM	TF	ASCC3	ZNF710	0.810080233	1.34E-29
THYM	TF	ASCC3	ZNF641	0.81020997	1.29E-29
THYM	TF	ASCC3	ZNF623	0.81022503	1.29E-29
THYM	TF	ASCC3	BBX	0.810275698	1.27E-29
THYM	TF	ASCC3	ZNF217	0.811156703	9.86E-30
THYM	TF	ASCC3	ZNF180	0.812061458	7.61E-30
THYM	TF	ASCC3	ZNF407	0.812732347	6.27E-30
THYM	TF	ASCC3	ZZZ3	0.812851228	6.06E-30
THYM	TF	ASCC3	ZNF611	0.812917116	5.95E-30
THYM	TF	ASCC3	ZNF614	0.813494207	5.03E-30
THYM	TF	ASCC3	ZNF627	0.814352251	3.92E-30
THYM	TF	ASCC3	ZSCAN12	0.815861838	2.52E-30
THYM	TF	ASCC3	ZNF28	0.819408539	8.79E-31
THYM	TF	ASCC3	ZNF225	0.819968675	7.42E-31
THYM	TF	ASCC3	SP4	0.820262039	6.80E-31
THYM	TF	ASCC3	ZNF254	0.8210631	5.33E-31
THYM	TF	ASCC3	JRKL	0.82165836	4.45E-31
THYM	TF	ASCC3	HIVEP1	0.82191284	4.12E-31
THYM	TF	ASCC3	ZNF432	0.822092375	3.90E-31
THYM	TF	ASCC3	NCOA2	0.822121216	3.86E-31
THYM	TF	ASCC3	TMF1	0.82242178	3.52E-31
THYM	TF	ASCC3	ZNF292	0.822843496	3.10E-31
THYM	TF	ASCC3	ZNF644	0.828801851	4.80E-32
THYM	TF	ASCC3	ZNF570	0.828953829	4.57E-32
THYM	TF	ASCC3	ZNF800	0.829825089	3.46E-32
THYM	TF	ASCC3	RREB1	0.830503649	2.78E-32
THYM	TF	ASCC3	ZNF134	0.830690872	2.62E-32
THYM	TF	ASCC3	ZBTB10	0.834994573	6.40E-33
THYM	TF	ASCC3	ZNF776	0.835067916	6.25E-33
THYM	TF	ASCC3	SPEN	0.835576277	5.27E-33
THYM	TF	ASCC3	SP3	0.836042436	4.51E-33
THYM	TF	ASCC3	ADNP	0.836733343	3.58E-33
THYM	TF	ASCC3	ZNF426	0.836986908	3.29E-33
THYM	TF	ASCC3	SON	0.839064491	1.63E-33
THYM	TF	ASCC3	ZNF420	0.83909534	1.61E-33
THYM	TF	ASCC3	ZNF146	0.845206281	1.91E-34
THYM	TF	ASCC3	TET3	0.847828217	7.44E-35
THYM	TF	ASCC3	ZNF765	0.849646819	3.83E-35
THYM	TF	ASCC3	ZNF281	0.849713226	3.74E-35
THYM	TF	ASCC3	NR2C2	0.85278662	1.19E-35
THYM	TF	ASCC3	RLF	0.853120315	1.05E-35
THYM	TF	ASCC3	ELK3	0.854411931	6.43E-36
THYM	TF	ASCC3	ZNF318	0.860441785	6.13E-37
THYM	TF	ASCC3	ZNF813	0.863495862	1.79E-37
THYM	TF	ASCC3	ZBTB39	0.863660725	1.67E-37
THYM	TF	ASCC3	MGA	0.865379358	8.24E-38
THYM	TF	ASCC3	REST	0.871173313	7.04E-39
THYM	TF	ASCC3	ZNF430	0.873370113	2.68E-39
THYM	TF	ASCC3	ATF2	0.87451995	1.61E-39
THYM	TF	ASCC3	BPTF	0.876511684	6.55E-40
THYM	TSG	ASCC3	USP12	0.800551808	1.86E-28
THYM	TSG	ASCC3	PHC3	0.805471407	4.87E-29
THYM	TSG	ASCC3	SIRT1	0.807930679	2.46E-29
THYM	TSG	ASCC3	TP53BP2	0.816503267	2.09E-30
THYM	TSG	ASCC3	NUP98	0.82109416	5.28E-31
THYM	TSG	ASCC3	HIVEP1	0.82191284	4.12E-31
THYM	TSG	ASCC3	ZNF292	0.822843496	3.10E-31
THYM	TSG	ASCC3	KDM3B	0.824222279	2.02E-31
THYM	TSG	ASCC3	ANAPC1	0.824491482	1.86E-31
THYM	TSG	ASCC3	VHL	0.826049953	1.15E-31
THYM	TSG	ASCC3	PTPN11	0.849547152	3.97E-35
THYM	TSG	ASCC3	LATS1	0.851434851	1.97E-35
THYM	TSG	ASCC3	NR2C2	0.85278662	1.19E-35
THYM	TSG	ASCC3	IGF2R	0.862192214	3.04E-37
THYM	TSG	ASCC3	BARD1	0.86608003	6.16E-38
THYM	TSG	ASCC3	SHPRH	0.869466172	1.47E-38
THYM	TSG	ASCC3	HACE1	0.884393257	1.60E-41
UCS	Cell metabolism gene	ASCC3	PDPR	0.801103486	1.61E-28
UCS	Cell metabolism gene	ASCC3	NEU3	0.801330523	1.51E-28
UCS	Cell metabolism gene	ASCC3	ARFGEF2	0.804123165	7.07E-29
UCS	Cell metabolism gene	ASCC3	AASDHPPT	0.807411477	2.84E-29
UCS	Cell metabolism gene	ASCC3	PIKFYVE	0.808916519	1.86E-29
UCS	Cell metabolism gene	ASCC3	EP300	0.809747036	1.47E-29
UCS	Cell metabolism gene	ASCC3	PI4K2B	0.811127653	9.94E-30
UCS	Cell metabolism gene	ASCC3	ACER2	0.813753748	4.67E-30
UCS	Cell metabolism gene	ASCC3	PIK3R4	0.815746542	2.61E-30
UCS	Cell metabolism gene	ASCC3	UGCG	0.816847993	1.89E-30
UCS	Cell metabolism gene	ASCC3	SEC24B	0.817527778	1.54E-30
UCS	Cell metabolism gene	ASCC3	RQCD1	0.819970575	7.42E-31
UCS	Cell metabolism gene	ASCC3	POLR2B	0.820048246	7.25E-31
UCS	Cell metabolism gene	ASCC3	MED23	0.821126459	5.23E-31
UCS	Cell metabolism gene	ASCC3	NCOA2	0.822121216	3.86E-31
UCS	Cell metabolism gene	ASCC3	RANBP2	0.826176763	1.10E-31
UCS	Cell metabolism gene	ASCC3	PAFAH1B2	0.826883208	8.82E-32
UCS	Cell metabolism gene	ASCC3	CDK8	0.827001911	8.49E-32
UCS	Cell metabolism gene	ASCC3	PHAX	0.82715482	8.09E-32
UCS	Cell metabolism gene	ASCC3	GLS	0.830008702	3.26E-32
UCS	Cell metabolism gene	ASCC3	MUT	0.832216386	1.60E-32
UCS	Cell metabolism gene	ASCC3	NCOA6	0.841870172	6.18E-34
UCS	Cell metabolism gene	ASCC3	PATL1	0.842490654	4.98E-34
UCS	Cell metabolism gene	ASCC3	MED1	0.843957735	2.97E-34
UCS	Cell metabolism gene	ASCC3	SMG1	0.844410235	2.53E-34
UCS	Cell metabolism gene	ASCC3	NCOR1	0.847844476	7.39E-35
UCS	Cell metabolism gene	ASCC3	SEC24D	0.849581937	3.92E-35
UCS	Cell metabolism gene	ASCC3	GLUD2	0.853132683	1.04E-35
UCS	Cell metabolism gene	ASCC3	PIK3CA	0.853184075	1.02E-35
UCS	Cell metabolism gene	ASCC3	SYNJ2	0.862010605	3.27E-37
UCS	Cell metabolism gene	ASCC3	UPF2	0.880028611	1.29E-40
UCS	Cell metabolism gene	ASCC3	MANEA	0.880033959	1.29E-40
UCS	Cell metabolism gene	ASCC3	NUP153	0.898180316	1.20E-44
UCS	CGC	ASCC3	CREB1	0.802954156	9.73E-29
UCS	CGC	ASCC3	BRD4	0.803048132	9.48E-29
UCS	CGC	ASCC3	EP300	0.809747036	1.47E-29
UCS	CGC	ASCC3	PPM1D	0.810120689	1.32E-29
UCS	CGC	ASCC3	CHD2	0.810620579	1.15E-29
UCS	CGC	ASCC3	UBR5	0.816292926	2.22E-30
UCS	CGC	ASCC3	NUP98	0.82109416	5.28E-31
UCS	CGC	ASCC3	NCOA2	0.822121216	3.86E-31
UCS	CGC	ASCC3	TRRAP	0.82441144	1.91E-31
UCS	CGC	ASCC3	VHL	0.826049953	1.15E-31
UCS	CGC	ASCC3	RANBP2	0.826176763	1.10E-31
UCS	CGC	ASCC3	PAFAH1B2	0.826883208	8.82E-32
UCS	CGC	ASCC3	ATRX	0.828154071	5.90E-32
UCS	CGC	ASCC3	NSD1	0.83500416	6.38E-33
UCS	CGC	ASCC3	SPEN	0.835576277	5.27E-33
UCS	CGC	ASCC3	GOPC	0.838206111	2.18E-33
UCS	CGC	ASCC3	STRN	0.842391393	5.15E-34
UCS	CGC	ASCC3	MLLT10	0.84752733	8.30E-35
UCS	CGC	ASCC3	MAPK1	0.847588702	8.11E-35
UCS	CGC	ASCC3	NCOR1	0.847844476	7.39E-35
UCS	CGC	ASCC3	PTPN11	0.849547152	3.97E-35
UCS	CGC	ASCC3	LATS1	0.851434851	1.97E-35
UCS	CGC	ASCC3	PIK3CA	0.853184075	1.02E-35
UCS	CGC	ASCC3	N4BP2	0.859006635	1.08E-36
UCS	CGC	ASCC3	BARD1	0.86608003	6.16E-38
UCS	CGC	ASCC3	FUBP1	0.873772193	2.25E-39
UCS	CGC	ASCC3	ARID1B	0.874415435	1.69E-39
UCS	CGC	ASCC3	BIRC6	0.887560658	3.32E-42
UCS	CGC	ASCC3	BCLAF1	0.900940669	2.50E-45
UCS	CGC	ASCC3	STAG1	0.903487768	5.66E-46
UCS	Epifactor	ASCC3	USP12	0.800551808	1.86E-28
UCS	Epifactor	ASCC3	BRD4	0.803048132	9.48E-29
UCS	Epifactor	ASCC3	GTF2I	0.80461479	6.17E-29
UCS	Epifactor	ASCC3	PHC3	0.805471407	4.87E-29
UCS	Epifactor	ASCC3	CTR9	0.805589316	4.72E-29
UCS	Epifactor	ASCC3	SIRT1	0.807930679	2.46E-29
UCS	Epifactor	ASCC3	EP300	0.809747036	1.47E-29
UCS	Epifactor	ASCC3	TAF1L	0.810131458	1.32E-29
UCS	Epifactor	ASCC3	RLIM	0.810304695	1.26E-29
UCS	Epifactor	ASCC3	CHD2	0.810620579	1.15E-29
UCS	Epifactor	ASCC3	SMEK2	0.810905773	1.06E-29
UCS	Epifactor	ASCC3	ZNF217	0.811156703	9.86E-30
UCS	Epifactor	ASCC3	ZZZ3	0.812851228	6.06E-30
UCS	Epifactor	ASCC3	UBR5	0.816292926	2.22E-30
UCS	Epifactor	ASCC3	NCOA2	0.822121216	3.86E-31
UCS	Epifactor	ASCC3	RBBP5	0.823971952	2.19E-31
UCS	Epifactor	ASCC3	KDM3B	0.824222279	2.02E-31
UCS	Epifactor	ASCC3	TRRAP	0.82441144	1.91E-31
UCS	Epifactor	ASCC3	JMJD1C	0.825046658	1.57E-31
UCS	Epifactor	ASCC3	TAF1	0.825161847	1.51E-31
UCS	Epifactor	ASCC3	MPHOSPH8	0.827040494	8.39E-32
UCS	Epifactor	ASCC3	UBR2	0.827076611	8.30E-32
UCS	Epifactor	ASCC3	RNF168	0.827628205	6.97E-32
UCS	Epifactor	ASCC3	ATRX	0.828154071	5.90E-32
UCS	Epifactor	ASCC3	TADA2A	0.831303547	2.15E-32
UCS	Epifactor	ASCC3	NSD1	0.83500416	6.38E-33
UCS	Epifactor	ASCC3	SPEN	0.835576277	5.27E-33
UCS	Epifactor	ASCC3	ADNP	0.836733343	3.58E-33
UCS	Epifactor	ASCC3	NCOA6	0.841870172	6.18E-34
UCS	Epifactor	ASCC3	RSF1	0.842957664	4.23E-34
UCS	Epifactor	ASCC3	PHF8	0.843146356	3.96E-34
UCS	Epifactor	ASCC3	EPC2	0.847432707	8.59E-35
UCS	Epifactor	ASCC3	MLLT10	0.84752733	8.30E-35
UCS	Epifactor	ASCC3	TET3	0.847828217	7.44E-35
UCS	Epifactor	ASCC3	NCOR1	0.847844476	7.39E-35
UCS	Epifactor	ASCC3	SMARCAD1	0.848080053	6.79E-35
UCS	Epifactor	ASCC3	TAF2	0.848275504	6.32E-35
UCS	Epifactor	ASCC3	C11orf30	0.851055918	2.27E-35
UCS	Epifactor	ASCC3	EPC1	0.852712918	1.22E-35
UCS	Epifactor	ASCC3	DDX21	0.853000843	1.10E-35
UCS	Epifactor	ASCC3	BRPF3	0.853030883	1.09E-35
UCS	Epifactor	ASCC3	PPP4R2	0.858722991	1.21E-36
UCS	Epifactor	ASCC3	ZRANB3	0.86297208	2.21E-37
UCS	Epifactor	ASCC3	MGA	0.865379358	8.24E-38
UCS	Epifactor	ASCC3	BARD1	0.86608003	6.16E-38
UCS	Epifactor	ASCC3	SHPRH	0.869466172	1.47E-38
UCS	Epifactor	ASCC3	REST	0.871173313	7.04E-39
UCS	Epifactor	ASCC3	MAP3K7	0.871661079	5.69E-39
UCS	Epifactor	ASCC3	ARID1B	0.874415435	1.69E-39
UCS	Epifactor	ASCC3	ATF2	0.87451995	1.61E-39
UCS	Epifactor	ASCC3	BPTF	0.876511684	6.55E-40
UCS	Epifactor	ASCC3	SMARCA5	0.882985968	3.16E-41
UCS	IUPHAR	ASCC3	ATP13A3	0.801067295	1.62E-28
UCS	IUPHAR	ASCC3	ERN1	0.80280484	1.01E-28
UCS	IUPHAR	ASCC3	BRD4	0.803048132	9.48E-29
UCS	IUPHAR	ASCC3	NEK1	0.806114175	4.08E-29
UCS	IUPHAR	ASCC3	NEK4	0.80637335	3.80E-29
UCS	IUPHAR	ASCC3	SIRT1	0.807930679	2.46E-29
UCS	IUPHAR	ASCC3	PIKFYVE	0.808916519	1.86E-29
UCS	IUPHAR	ASCC3	EP300	0.809747036	1.47E-29
UCS	IUPHAR	ASCC3	PPM1D	0.810120689	1.32E-29
UCS	IUPHAR	ASCC3	TAF1L	0.810131458	1.32E-29
UCS	IUPHAR	ASCC3	PI4K2B	0.811127653	9.94E-30
UCS	IUPHAR	ASCC3	SLC30A5	0.811885857	8.00E-30
UCS	IUPHAR	ASCC3	TMEM30A	0.813147579	5.56E-30
UCS	IUPHAR	ASCC3	ACER2	0.813753748	4.67E-30
UCS	IUPHAR	ASCC3	PDPK1	0.815341977	2.94E-30
UCS	IUPHAR	ASCC3	SLC25A40	0.815423074	2.87E-30
UCS	IUPHAR	ASCC3	PIK3R4	0.815746542	2.61E-30
UCS	IUPHAR	ASCC3	UGCG	0.816847993	1.89E-30
UCS	IUPHAR	ASCC3	SLC39A10	0.817006978	1.80E-30
UCS	IUPHAR	ASCC3	SLC38A7	0.819414319	8.77E-31
UCS	IUPHAR	ASCC3	NCOA2	0.822121216	3.86E-31
UCS	IUPHAR	ASCC3	KDM3B	0.824222279	2.02E-31
UCS	IUPHAR	ASCC3	TRRAP	0.82441144	1.91E-31
UCS	IUPHAR	ASCC3	SLC25A24	0.824729046	1.73E-31
UCS	IUPHAR	ASCC3	JMJD1C	0.825046658	1.57E-31
UCS	IUPHAR	ASCC3	TAF1	0.825161847	1.51E-31
UCS	IUPHAR	ASCC3	SLC10A7	0.825642173	1.30E-31
UCS	IUPHAR	ASCC3	CDK8	0.827001911	8.49E-32
UCS	IUPHAR	ASCC3	SLC35A3	0.829303873	4.09E-32
UCS	IUPHAR	ASCC3	SLK	0.829709813	3.59E-32
UCS	IUPHAR	ASCC3	GLS	0.830008702	3.26E-32
UCS	IUPHAR	ASCC3	HIPK3	0.833451101	1.07E-32
UCS	IUPHAR	ASCC3	NSD1	0.83500416	6.38E-33
UCS	IUPHAR	ASCC3	TNKS	0.83862545	1.89E-33
UCS	IUPHAR	ASCC3	PHF8	0.843146356	3.96E-34
UCS	IUPHAR	ASCC3	SMG1	0.844410235	2.53E-34
UCS	IUPHAR	ASCC3	DPP8	0.847355881	8.83E-35
UCS	IUPHAR	ASCC3	MAPK1	0.847588702	8.11E-35
UCS	IUPHAR	ASCC3	TNKS2	0.85135301	2.04E-35
UCS	IUPHAR	ASCC3	LATS1	0.851434851	1.97E-35
UCS	IUPHAR	ASCC3	NR2C2	0.85278662	1.19E-35
UCS	IUPHAR	ASCC3	BRPF3	0.853030883	1.09E-35
UCS	IUPHAR	ASCC3	PIK3CA	0.853184075	1.02E-35
UCS	IUPHAR	ASCC3	ADAM17	0.856924902	2.45E-36
UCS	IUPHAR	ASCC3	SENP6	0.858469265	1.34E-36
UCS	IUPHAR	ASCC3	SYNJ2	0.862010605	3.27E-37
UCS	IUPHAR	ASCC3	SCYL2	0.862800354	2.37E-37
UCS	IUPHAR	ASCC3	MAP3K7	0.871661079	5.69E-39
UCS	IUPHAR	ASCC3	MAPK8	0.872364033	4.18E-39
UCS	IUPHAR	ASCC3	BPTF	0.876511684	6.55E-40
UCS	IUPHAR	ASCC3	ADAM10	0.876888863	5.52E-40
UCS	IUPHAR	ASCC3	BIRC6	0.887560658	3.32E-42
UCS	Kinase	ASCC3	ERN1	0.80280484	1.01E-28
UCS	Kinase	ASCC3	BRD4	0.803048132	9.48E-29
UCS	Kinase	ASCC3	NEK1	0.806114175	4.08E-29
UCS	Kinase	ASCC3	NEK4	0.80637335	3.80E-29
UCS	Kinase	ASCC3	TAF1L	0.810131458	1.32E-29
UCS	Kinase	ASCC3	PDPK1	0.815341977	2.94E-30
UCS	Kinase	ASCC3	PIK3R4	0.815746542	2.61E-30
UCS	Kinase	ASCC3	TRRAP	0.82441144	1.91E-31
UCS	Kinase	ASCC3	TAF1	0.825161847	1.51E-31
UCS	Kinase	ASCC3	CDK8	0.827001911	8.49E-32
UCS	Kinase	ASCC3	SLK	0.829709813	3.59E-32
UCS	Kinase	ASCC3	HIPK3	0.833451101	1.07E-32
UCS	Kinase	ASCC3	SMG1	0.844410235	2.53E-34
UCS	Kinase	ASCC3	MAPK1	0.847588702	8.11E-35
UCS	Kinase	ASCC3	LATS1	0.851434851	1.97E-35
UCS	Kinase	ASCC3	SCYL2	0.862800354	2.37E-37
UCS	Kinase	ASCC3	MAP3K7	0.871661079	5.69E-39
UCS	Kinase	ASCC3	MAPK8	0.872364033	4.18E-39
UCS	TF	ASCC3	ZNF543	0.802756013	1.03E-28
UCS	TF	ASCC3	CREB1	0.802954156	9.73E-29
UCS	TF	ASCC3	ZNF91	0.804533486	6.31E-29
UCS	TF	ASCC3	GTF2I	0.80461479	6.17E-29
UCS	TF	ASCC3	ZFP91	0.804940123	5.64E-29
UCS	TF	ASCC3	ZNF689	0.807223376	3.00E-29
UCS	TF	ASCC3	ZNF710	0.810080233	1.34E-29
UCS	TF	ASCC3	ZNF641	0.81020997	1.29E-29
UCS	TF	ASCC3	ZNF623	0.81022503	1.29E-29
UCS	TF	ASCC3	BBX	0.810275698	1.27E-29
UCS	TF	ASCC3	ZNF217	0.811156703	9.86E-30
UCS	TF	ASCC3	ZNF180	0.812061458	7.61E-30
UCS	TF	ASCC3	ZNF407	0.812732347	6.27E-30
UCS	TF	ASCC3	ZZZ3	0.812851228	6.06E-30
UCS	TF	ASCC3	ZNF611	0.812917116	5.95E-30
UCS	TF	ASCC3	ZNF614	0.813494207	5.03E-30
UCS	TF	ASCC3	ZNF627	0.814352251	3.92E-30
UCS	TF	ASCC3	ZSCAN12	0.815861838	2.52E-30
UCS	TF	ASCC3	ZNF28	0.819408539	8.79E-31
UCS	TF	ASCC3	ZNF225	0.819968675	7.42E-31
UCS	TF	ASCC3	SP4	0.820262039	6.80E-31
UCS	TF	ASCC3	ZNF254	0.8210631	5.33E-31
UCS	TF	ASCC3	JRKL	0.82165836	4.45E-31
UCS	TF	ASCC3	HIVEP1	0.82191284	4.12E-31
UCS	TF	ASCC3	ZNF432	0.822092375	3.90E-31
UCS	TF	ASCC3	NCOA2	0.822121216	3.86E-31
UCS	TF	ASCC3	TMF1	0.82242178	3.52E-31
UCS	TF	ASCC3	ZNF292	0.822843496	3.10E-31
UCS	TF	ASCC3	ZNF644	0.828801851	4.80E-32
UCS	TF	ASCC3	ZNF570	0.828953829	4.57E-32
UCS	TF	ASCC3	ZNF800	0.829825089	3.46E-32
UCS	TF	ASCC3	RREB1	0.830503649	2.78E-32
UCS	TF	ASCC3	ZNF134	0.830690872	2.62E-32
UCS	TF	ASCC3	ZBTB10	0.834994573	6.40E-33
UCS	TF	ASCC3	ZNF776	0.835067916	6.25E-33
UCS	TF	ASCC3	SPEN	0.835576277	5.27E-33
UCS	TF	ASCC3	SP3	0.836042436	4.51E-33
UCS	TF	ASCC3	ADNP	0.836733343	3.58E-33
UCS	TF	ASCC3	ZNF426	0.836986908	3.29E-33
UCS	TF	ASCC3	SON	0.839064491	1.63E-33
UCS	TF	ASCC3	ZNF420	0.83909534	1.61E-33
UCS	TF	ASCC3	ZNF146	0.845206281	1.91E-34
UCS	TF	ASCC3	TET3	0.847828217	7.44E-35
UCS	TF	ASCC3	ZNF765	0.849646819	3.83E-35
UCS	TF	ASCC3	ZNF281	0.849713226	3.74E-35
UCS	TF	ASCC3	NR2C2	0.85278662	1.19E-35
UCS	TF	ASCC3	RLF	0.853120315	1.05E-35
UCS	TF	ASCC3	ELK3	0.854411931	6.43E-36
UCS	TF	ASCC3	ZNF318	0.860441785	6.13E-37
UCS	TF	ASCC3	ZNF813	0.863495862	1.79E-37
UCS	TF	ASCC3	ZBTB39	0.863660725	1.67E-37
UCS	TF	ASCC3	MGA	0.865379358	8.24E-38
UCS	TF	ASCC3	REST	0.871173313	7.04E-39
UCS	TF	ASCC3	ZNF430	0.873370113	2.68E-39
UCS	TF	ASCC3	ATF2	0.87451995	1.61E-39
UCS	TF	ASCC3	BPTF	0.876511684	6.55E-40
UCS	TSG	ASCC3	USP12	0.800551808	1.86E-28
UCS	TSG	ASCC3	PHC3	0.805471407	4.87E-29
UCS	TSG	ASCC3	SIRT1	0.807930679	2.46E-29
UCS	TSG	ASCC3	TP53BP2	0.816503267	2.09E-30
UCS	TSG	ASCC3	NUP98	0.82109416	5.28E-31
UCS	TSG	ASCC3	HIVEP1	0.82191284	4.12E-31
UCS	TSG	ASCC3	ZNF292	0.822843496	3.10E-31
UCS	TSG	ASCC3	KDM3B	0.824222279	2.02E-31
UCS	TSG	ASCC3	ANAPC1	0.824491482	1.86E-31
UCS	TSG	ASCC3	VHL	0.826049953	1.15E-31
UCS	TSG	ASCC3	PTPN11	0.849547152	3.97E-35
UCS	TSG	ASCC3	LATS1	0.851434851	1.97E-35
UCS	TSG	ASCC3	NR2C2	0.85278662	1.19E-35
UCS	TSG	ASCC3	IGF2R	0.862192214	3.04E-37
UCS	TSG	ASCC3	BARD1	0.86608003	6.16E-38
UCS	TSG	ASCC3	SHPRH	0.869466172	1.47E-38
UCS	TSG	ASCC3	HACE1	0.884393257	1.60E-41
UVM	Cell metabolism gene	ASCC3	TRMT11	0.815887913	3.04E-20
UVM	Cell metabolism gene	ASCC3	MANEA	0.820523129	1.24E-20
UVM	Cell metabolism gene	ASCC3	PGM3	0.829212411	2.13E-21
UVM	Cell metabolism gene	ASCC3	COL4A3BP	0.839643194	2.24E-22
UVM	Cell metabolism gene	ASCC3	CCNC	0.869185412	1.44E-25
UVM	Cell metabolism gene	ASCC3	MED23	0.872042454	6.43E-26
UVM	CGC	ASCC3	LATS1	0.800985398	4.67E-19
UVM	CGC	ASCC3	FGFR1OP	0.803702434	2.89E-19
UVM	CGC	ASCC3	GOPC	0.826921749	3.41E-21
UVM	CGC	ASCC3	CCNC	0.869185412	1.44E-25
UVM	Epifactor	ASCC3	MAP3K7	0.861695223	1.09E-24
UVM	IUPHAR	ASCC3	LATS1	0.800985398	4.67E-19
UVM	IUPHAR	ASCC3	MAP3K2	0.807641499	1.42E-19
UVM	IUPHAR	ASCC3	TMEM30A	0.809521974	1.01E-19
UVM	IUPHAR	ASCC3	TNKS2	0.814110937	4.26E-20
UVM	IUPHAR	ASCC3	IFNGR1	0.845196486	6.35E-23
UVM	IUPHAR	ASCC3	MAP3K7	0.861695223	1.09E-24
UVM	Kinase	ASCC3	LATS1	0.800985398	4.67E-19
UVM	Kinase	ASCC3	MAP3K2	0.807641499	1.42E-19
UVM	Kinase	ASCC3	COL4A3BP	0.839643194	2.24E-22
UVM	Kinase	ASCC3	MAP3K7	0.861695223	1.09E-24
UVM	TSG	ASCC3	LATS1	0.800985398	4.67E-19
UVM	TSG	ASCC3	SOD2	0.807924238	1.35E-19
UVM	TSG	ASCC3	PDSS2	0.845664289	5.69E-23
UVM	TSG	ASCC3	CCNC	0.869185412	1.44E-25

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	ASCC3	ASCC2	-3.16145158043654	0.000157924260899676
COAD	ASCC3	ASCC1	-1.08291850716374	0.00028228759765625
STAD	ASCC3	ZNF598	1.90805357051412	0.000433447770774365
COAD	ASCC3	CDC5L	-2.92762646435926	0.00177955627441406
LIHC	ASCC3	ZNF598	-2.14881301213792	0.00182077236082954
HNSC	ASCC3	ASCC1	-1.15387951517859	0.00302236390302824
THCA	ASCC3	ANKZF1	-3.43650164630031	0.00681094256685597
KIRP	ASCC3	ANKZF1	-1.61132866975132	0.0105091729201376
KIRP	ASCC3	TRIP4	-1.39464355922267	0.0124990218318999
CHOL	ASCC3	PRPF8	-1.71206315303684	0.01953125
ESCA	ASCC3	ZNF598	1.25106219261408	0.0244140625
UCEC	ASCC3	ANKZF1	2.7268611217094	0.046875
KICH	ASCC3	ANKZF1	1.27322087580613	1.0073184967041e-05
KIRC	ASCC3	ANKZF1	-2.12424646752068	1.03420313223267e-10
BRCA	ASCC3	ZNF598	-1.1638047490822	1.46241900078771e-11
BRCA	ASCC3	PRPF8	-2.58159913381184	1.63428227339056e-08
LUSC	ASCC3	ANKZF1	-2.85359504487486	1.96457667164042e-06
LUAD	ASCC3	ZNF598	-2.12729389726251	3.16320496270304e-09
PRAD	ASCC3	ZNF598	-1.44121746895011	3.48452906745071e-06
PRAD	ASCC3	ASCC1	1.85803625084882	3.62784175771099e-05
LUAD	ASCC3	ANKZF1	-3.18847532900235	3.64267431164553e-07
KICH	ASCC3	CDC5L	1.66472252294517	3.814697265625e-05
LIHC	ASCC3	ANKZF1	-3.17956706455575	4.0207800187107e-07
KIRP	ASCC3	ZNF598	-2.13529054966028	4.6566128730774e-09
KIRC	ASCC3	ASCC1	1.17322821298021	4.78942706319417e-05
LUAD	ASCC3	ASCC1	-3.45972551520068	6.05809956862828e-05
STAD	ASCC3	ANKZF1	-1.1841020236204	6.68526627123356e-05
HNSC	ASCC3	ZNF598	1.19099633730873	8.09852713246075e-05
LIHC	ASCC3	TRIP4	-2.05741049955716	8.10485983396854e-07
KICH	ASCC3	TRIP4	-2.18314831686334	8.80360603332519e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ASCC3

EIF3F, OTUD6B, G3BP1, G3BP2, SIRT7, CAND1, NOTCH1, SKIL, SOX2, HECW2, LGR4, ENO1, MOV10, NXF1, CCDC8, ALKBH3, RPS2, ASCC1, THBS3, ASCC2, NTRK1, IFI16, CC2D2A, CEP170, CEP128, CDK1, IQGAP1, Rpl35, Srp72, Rrbp1, HCCS, ZNF263, UBC, ZNF598, RPS3, PABPC1, ASCC3, BTF3, CDK12, DNA2, EIF3H, FARSA, GFI1B, CEP295, LEO1, MBTPS2, METAP2, NUDC, RBM25, RINT1, RPLP1, SEC22B, SRP19, USE1, WDR61, WDR7, XPO1, TRIP4, CHD3, CDC34, ESR2, EZH2, RECQL4, DCPS, MB21D1, MYC, KIAA1429, ATG16L1, NR2C2, GBF1, CD74, DDX60, CDC14A, DUSP2, PTPN6, LMBR1L, NFX1, WWP2, BRD7, TRIM28, PLEKHA4, MIB1, PTEN, PYCR1, VIM, nsp2, ESR1, DDX3X, STAU1, TRIM56, MKRN2, TDRD3, PAIP1, FXR2, LRRC31, BRD1, BRPF3, nsp2ab, LRRC59, NDN, Apc2, nsp15, LGALS9, USP10, DNAJA2, DNAJC7, ARPC5, ISG15, GOLGA1, IMPDH2, RPS20, NOG, RPS13, DGKZ, PPP4R1L, HNRNPCL2, PTGES3, HSD17B7P2, DGCR2, ENTPD1, LOC388882, ABT1, PURG, RPS6, TRIM52, PABPC5, PVALB, TTC9C, BEX1, UBXN6, BAG2, FAM96A, INF2, PLBD1, RPS10, NT5C, KLHL34, B4GALT2, HDHD1, ZNF252P-AS1, HSPB8, METTL21B, RBM4B, CIB2, FBXW7, Rrp1, FBXO32, SIRT6,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
ASCC3	chr6	100960590	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	100960780	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	100988121	T	C	single_nucleotide_variant	Uncertain_significance	See_cases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	101079039	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ASCC3	chr6	101086528	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ASCC3	chr6	101090545	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ASCC3	chr6	101094516	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	101095145	CT	C	Deletion	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
ASCC3	chr6	101098518	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	101100754	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ASCC3	chr6	101100783	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ASCC3	chr6	101103634	GA	G	Deletion	Uncertain_significance	not_specified	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
ASCC3	chr6	101163360	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	101163364	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ASCC3	chr6	101215020	C	A	single_nucleotide_variant	Uncertain_significance	not_specified\|not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
ASCC3	chr6	101215223	TA	T	Deletion	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ASCC3	chr6	101253659	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	101296023	C	A	single_nucleotide_variant	Likely_pathogenic	See_cases	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
ASCC3	chr6	101296285	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ASCC3	chr6	101296544	G	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ASCC3	chr6	101312005	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ASCC3	COAD	chr6	101296418	101296418	C	T	Missense_Mutation	p.R136Q	10
ASCC3	LUAD	chr6	101095256	101095256	C	A	Missense_Mutation	p.R1108S	5
ASCC3	ESCA	chr6	101076966	101076966	C	A	Missense_Mutation	p.V1434F	5
ASCC3	ESCA	chr6	101103625	101103625	G	A	Missense_Mutation	p.R925W	5
ASCC3	READ	chr6	101296284	101296284	C	T	Missense_Mutation	p.E181K	5
ASCC3	SKCM	chr6	100957860	100957860	G	A	Nonsense_Mutation	p.R2137*	5
ASCC3	KIRC	chr6	101095127	101095127	C	A	Silent	p.L1151L	5
ASCC3	STAD	chr6	101127558	101127558	T	-	Frame_Shift_Del	p.N741fs	4
ASCC3	UCEC	chr6	101053536	101053536	G	A	Silent	p.F1695	4
ASCC3	KIRP	chr6	101296249	101296249	T	A	Silent	p.I192I	4
ASCC3	LIHC	chr6	101095146	101095146	T	-	Frame_Shift_Del	p.K1145fs	4
ASCC3	BRCA	chr6	101054655	101054655	C	G	Missense_Mutation	p.D1669H	4
ASCC3	BRCA	chr6	101073157	101073157	G	A	Missense_Mutation	p.R1566C	4
ASCC3	UCEC	chr6	100957933	100957933	G	A	Silent	p.D2112	4
ASCC3	UCS	chr6	101248328	101248328	T	G	Missense_Mutation	p.Q325H	3
ASCC3	ESCA	chr6	100988137	100988137	G	T	Missense_Mutation	p.L1893I	3
ASCC3	UCEC	chr6	101049705	101049705	G	A	Missense_Mutation	p.R1762C	3
ASCC3	SKCM	chr6	101053472	101053472	G	A	Missense_Mutation	p.L1717F	3
ASCC3	UCEC	chr6	101110257	101110257	C	A	Missense_Mutation	p.W814C	3
ASCC3	UVM	chr6	101075567	101075567	C	T	Missense_Mutation	p.R1514Q	3
ASCC3	ACC	chr6	101246658	101246658	C	G	Missense_Mutation	p.R442S	3
ASCC3	PRAD	chr6	101098516	101098516	T	C	Silent	p.V1050V	3
ASCC3	UCEC	chr6	101315843	101315843	G	A	Missense_Mutation	p.R11C	3
ASCC3	UVM	chr6	101075824	101075824	C	T	Missense_Mutation	p.R1472Q	3
ASCC3	ESCA	chr6	101099510	101099510	G	C	Missense_Mutation	p.L1001V	3
ASCC3	GBM	chr6	101037629	101037629	C	T	Missense_Mutation	p.E1811K	3
ASCC3	HNSC	chr6	100964151	100964151	C	A	Nonsense_Mutation	p.E1994*	3
ASCC3	LIHC	chr6	101094554	101094554	A	G	Silent		3
ASCC3	KIRP	chr6	101075824	101075824	C	A	Missense_Mutation	p.R1472L	3
ASCC3	STAD	chr6	101091910	101091910	T	-	Frame_Shift_Del	p.Q1244fs	3
ASCC3	UCEC	chr6	101248252	101248252	C	G	Missense_Mutation	p.E351Q	3
ASCC3	KIRP	chr6	101075824	101075824	C	A	Missense_Mutation		3
ASCC3	UCEC	chr6	101296063	101296063	C	T	Missense_Mutation	p.M254I	3
ASCC3	LUAD	chr6	101073106	101073106	C	T	Missense_Mutation	p.E1583K	3
ASCC3	LIHC	chr6	101248245	101248245	T	-	Frame_Shift_Del	p.K353fs	3
ASCC3	PAAD	chr6	101054895	101054895	G	A	Missense_Mutation	p.H1619Y	3
ASCC3	BLCA	chr6	100957932	100957932	C	T	Missense_Mutation	p.E2113K	3
ASCC3	LUAD	chr6	100957385	100957385	C	G	Missense_Mutation	p.M2162I	3
ASCC3	PAAD	chr6	101215160	101215160	T	C	Missense_Mutation	p.E486G	3
ASCC3	BRCA	chr6	101086576	101086576	C	T	Silent	p.T1341	3
ASCC3	STAD	chr6	101296426	101296426	A	G	Silent	p.A133A	2
ASCC3	UCEC	chr6	100960782	100960782	A	C	Missense_Mutation	p.L2030V	2
ASCC3	PAAD	chr6	101075801	101075801	T	C	Missense_Mutation	p.T1480A	2
ASCC3	SKCM	chr6	101173462	101173462	C	T	Missense_Mutation	p.D619N	2
ASCC3	SARC	chr6	101247339	101247339	T	C	Missense_Mutation		2
ASCC3	CESC	chr6	101315861	101315861	G	C	Missense_Mutation		2
ASCC3	HNSC	chr6	101296082	101296082	C	G	Missense_Mutation	p.C248S	2
ASCC3	STAD	chr6	101127565	101127565	C	-	Frame_Shift_Del	p.A739fs	2
ASCC3	UCEC	chr6	101095148	101095148	T	G	Missense_Mutation	p.K1144N	2
ASCC3	SKCM	chr6	100957947	100957947	G	A	Missense_Mutation	p.P2108S	2
ASCC3	STAD	chr6	101094585	101094585	G	A	Missense_Mutation	p.P1180L	2
ASCC3	UCEC	chr6	100988055	100988055	G	A	Missense_Mutation	p.A1920V	2
ASCC3	SKCM	chr6	101077016	101077016	G	A	Missense_Mutation	p.S1417F	2
ASCC3	CESC	chr6	101312040	101312040	C	T	Nonsense_Mutation	p.W47*	2
ASCC3	UCEC	chr6	101100728	101100728	A	C	Missense_Mutation	p.V954G	2
ASCC3	GBM	chr6	101037629	101037629	C	T	Missense_Mutation		2
ASCC3	STAD	chr6	101214491	101214491	C	T	Missense_Mutation	p.E563K	2
ASCC3	LIHC	chr6	100960788	100960788	T	A	Missense_Mutation	p.N2028Y	2
ASCC3	UCEC	chr6	101037618	101037618	A	C	Silent	p.T1814	2
ASCC3	BLCA	chr6	101246631	101246631	G	A	Silent	p.L451L	2
ASCC3	SKCM	chr6	101127554	101127554	A	G	Silent	p.C742C	2
ASCC3	HNSC	chr6	100964147	100964147	G	C	Missense_Mutation		2
ASCC3	STAD	chr6	101095278	101095278	C	T	Missense_Mutation	p.R1101H	2
ASCC3	UCEC	chr6	101109738	101109738	G	A	Nonsense_Mutation	p.R883*	2
ASCC3	SKCM	chr6	101100660	101100660	A	C	Missense_Mutation	p.S977A	2
ASCC3	STAD	chr6	101075830	101075830	A	G	Missense_Mutation	p.V1470A	2
ASCC3	THCA	chr6	101253689	101253689	A	G	Missense_Mutation	p.I290T	2
ASCC3	STAD	chr6	101091945	101091945	T	C	Missense_Mutation	p.I1232V	2
ASCC3	SKCM	chr6	101090551	101090551	G	A	Silent	p.I1269I	2
ASCC3	STAD	chr6	101109731	101109731	G	A	Missense_Mutation	p.P885L	2
ASCC3	LIHC	chr6	100960788	100960788	T	A	Missense_Mutation		2
ASCC3	UCEC	chr6	101110385	101110385	G	A	Nonsense_Mutation	p.R772*	2
ASCC3	BLCA	chr6	100966000	100966000	C	T	Missense_Mutation	p.A1932T	2
ASCC3	PAAD	chr6	101054895	101054895	G	A	Missense_Mutation		2
ASCC3	STAD	chr6	101103582	101103582	G	A	Missense_Mutation	p.A939V	2
ASCC3	STAD	chr6	101246682	101246682	A	G	Silent	p.N434N	2
ASCC3	UCEC	chr6	101054908	101054908	G	A	Silent	p.F1614	2
ASCC3	BLCA	chr6	101246631	101246631	G	A	Silent		2
ASCC3	BLCA	chr6	101037582	101037582	A	T	Missense_Mutation	p.H1826Q	2
ASCC3	STAD	chr6	101166009	101166009	C	T	Missense_Mutation	p.G674D	2
ASCC3	LIHC	chr6	101296578	101296578	T	C	Missense_Mutation		2
ASCC3	LUAD	chr6	101053528	101053528	T	A	Missense_Mutation	p.Q1698L	2
ASCC3	UCEC	chr6	101247440	101247440	G	A	Missense_Mutation	p.A379V	2
ASCC3	LUAD	chr6	100964152	100964152	G	T	Silent	p.I1993I	2
ASCC3	BLCA	chr6	101049784	101049784	T	G	Missense_Mutation	p.L1735F	2
ASCC3	PAAD	chr6	101075801	101075801	T	C	Missense_Mutation		2
ASCC3	STAD	chr6	101215064	101215064	C	T	Missense_Mutation	p.R518H	2
ASCC3	LIHC	chr6	101086535	101086535	T	-	Frame_Shift_Del	p.K1355fs	2
ASCC3	STAD	chr6	101166000	101166000	C	T	Missense_Mutation	p.R677Q	2
ASCC3	UCEC	chr6	101073174	101073174	A	C	Missense_Mutation	p.I1560R	2
ASCC3	BLCA	chr6	101214503	101214503	T	C	Missense_Mutation	p.I559V	2
ASCC3	GBM	chr6	101248186	101248186	G	A	Missense_Mutation	p.R373W	2
ASCC3	STAD	chr6	101246604	101246604	G	C	Missense_Mutation	p.I460M	2
ASCC3	UCEC	chr6	101248282	101248282	G	A	Nonsense_Mutation	p.R341*	2
ASCC3	STAD	chr6	101109778	101109778	C	T	Silent	p.T869T	2
ASCC3	PAAD	chr6	101215160	101215160	T	C	Missense_Mutation		2
ASCC3	SKCM	chr6	101296521	101296521	G	A	Missense_Mutation	p.H102Y	2
ASCC3	LIHC	chr6	101099464	101099464	G	C	Missense_Mutation		2
ASCC3	STAD	chr6	101086686	101086686	G	C	Missense_Mutation	p.L1305V	2
ASCC3	UCEC	chr6	101075555	101075555	C	T	Missense_Mutation	p.R1518H	2
ASCC3	LUAD	chr6	101073156	101073156	C	A	Missense_Mutation	p.R1566L	2
ASCC3	UCEC	chr6	101248367	101248367	T	G	Missense_Mutation	p.K312N	2
ASCC3	BRCA	chr6	101075523	101075523	A	T	Missense_Mutation	p.F1529I	2
ASCC3	LIHC	chr6	101054916	101054916	G	-	Frame_Shift_Del	p.L1612fs	2
ASCC3	LUAD	chr6	101053536	101053536	G	A	Silent	p.F1695F	2
ASCC3	SKCM	chr6	101109875	101109875	G	A	Missense_Mutation	p.S837F	2
ASCC3	STAD	chr6	101246645	101246645	C	T	Missense_Mutation	p.E447K	2
ASCC3	UCEC	chr6	101075556	101075556	G	A	Missense_Mutation	p.R1518C	2
ASCC3	BLCA	chr6	101103593	101103593	G	A	Silent	p.I935I	2
ASCC3	LUAD	chr6	101103674	101103674	A	G	Silent	p.T908T	2
ASCC3	UCEC	chr6	101296563	101296563	C	A	Nonsense_Mutation	p.E88*	2
ASCC3	BRCA	chr6	101075570	101075570	A	C	Missense_Mutation	p.F1513C	2
ASCC3	CHOL	chr6	101100758	101100758	G	C	Missense_Mutation	p.P944R	2
ASCC3	STAD	chr6	101037585	101037585	C	T	Silent	p.K1825K	2
ASCC3	LIHC	chr6	101296578	101296578	T	C	Missense_Mutation	p.T83A	2
ASCC3	LUAD	chr6	101075568	101075568	G	A	Nonsense_Mutation	p.R1514*	2
ASCC3	SKCM	chr6	101166119	101166119	G	A	Silent	p.S637S	2
ASCC3	ESCA	chr6	101076966	101076966	C	A	Missense_Mutation		2
ASCC3	HNSC	chr6	101054640	101054640	G	A	Missense_Mutation	p.R1674C	2
ASCC3	STAD	chr6	101095278	101095278	C	T	Missense_Mutation		2
ASCC3	STAD	chr6	101037604	101037604	G	A	Missense_Mutation	p.A1819V	2
ASCC3	UCEC	chr6	101090484	101090484	G	T	Missense_Mutation	p.L1292I	2
ASCC3	LUAD	chr6	101049771	101049771	C	T	Missense_Mutation	p.A1740T	2
ASCC3	UCEC	chr6	101311941	101311941	T	C	Missense_Mutation	p.I80M	2
ASCC3	SARC	chr6	101247339	101247339	T	C	Missense_Mutation	p.M413V	2
ASCC3	STAD	chr6	101099511	101099511	T	C	Silent	p.E1000E	2
ASCC3	LIHC	chr6	101166124	101166124	C	T	Missense_Mutation		2
ASCC3	STAD	chr6	101100601	101100601	C	A	Missense_Mutation	p.E996D	2
ASCC3	LUAD	chr6	100965956	100965956	C	G	Silent	p.L1946L	2
ASCC3	SKCM	chr6	101296463	101296463	G	A	Missense_Mutation	p.P121L	2
ASCC3	STAD	chr6	101109731	101109731	G	A	Missense_Mutation		2
ASCC3	STAD	chr6	101037562	101037562	T	A	Missense_Mutation	p.K1833M	2
ASCC3	UCEC	chr6	101090573	101090573	G	T	Missense_Mutation	p.P1262H	2
ASCC3	UCEC	chr6	101311967	101311967	C	A	Missense_Mutation	p.D72Y	2
ASCC3	STAD	chr6	101296277	101296277	G	T	Missense_Mutation	p.P183Q	2
ASCC3	STAD	chr6	101054919	101054919	T	C	Missense_Mutation	p.T1611A	2
ASCC3	BLCA	chr6	101110370	101110370	C	G	Missense_Mutation	p.D777H	2
ASCC3	SKCM	chr6	101086613	101086613	G	A	Missense_Mutation	p.P1329L	2
ASCC3	CESC	chr6	101248365	101248365	A	T	Missense_Mutation		2
ASCC3	ESCA	chr6	101099510	101099510	G	C	Missense_Mutation		2
ASCC3	UCEC	chr6	101091990	101091990	C	A	Nonsense_Mutation	p.G1217*	2
ASCC3	STAD	chr6	101296112	101296112	A	G	Missense_Mutation	p.M238T	2
ASCC3	LIHC	chr6	101166124	101166124	C	T	Missense_Mutation	p.E636K	2
ASCC3	HNSC	chr6	101215218	101215218	C	T	Missense_Mutation		1
ASCC3	SKCM	chr6	100988127	100988127	T	A	Missense_Mutation	p.Q1896L	1
ASCC3	LGG	chr6	101247437	101247437	A	C	Missense_Mutation	p.L380R	1
ASCC3	LIHC	chr6	101073192	101073192	G	-	Frame_Shift_Del	p.P1554fs	1
ASCC3	LUAD	chr6	100960595	100960595	C	A	Missense_Mutation	p.G2092V	1
ASCC3	BLCA	chr6	101215213	101215213	C	A	Missense_Mutation		1
ASCC3	BLCA	chr6	101163293	101163293	C	G	Nonstop_Mutation	p.*732Y	1
ASCC3	DLBC	chr6	101037846	101037846	G	A	Missense_Mutation	p.S1798F	1
ASCC3	HNSC	chr6	101076996	101076996	T	C	Missense_Mutation		1
ASCC3	BLCA	chr6	100957860	100957860	G	T	Silent		1
ASCC3	BLCA	chr6	101127582	101127582	A	G	Missense_Mutation	p.M733T	1
ASCC3	LUSC	chr6	101075504	101075504	C	A	Missense_Mutation	p.C1535F	1
ASCC3	ESCA	chr6	101166020	101166020	G	T	Missense_Mutation	p.F670L	1
ASCC3	LIHC	chr6	100957882	100957882	A	G	Silent		1
ASCC3	STAD	chr6	101165958	101165958	G	A	Missense_Mutation	p.A691V	1
ASCC3	LIHC	chr6	101110287	101110287	T	-	Frame_Shift_Del	p.K804fs	1
ASCC3	LUAD	chr6	101296580	101296580	C	T	Missense_Mutation	p.G82E	1
ASCC3	LIHC	chr6	101075740	101075740	G	T	Missense_Mutation	p.A1500D	1
ASCC3	THYM	chr6	100964126	100964126	G	T	Missense_Mutation	p.A2002D	1
ASCC3	LUAD	chr6	100957984	100957984	C	A	Splice_Site		1
ASCC3	BLCA	chr6	101103664	101103664	C	G	Missense_Mutation	p.E912Q	1
ASCC3	OV	chr6	100957917	100957917	T	C	Missense_Mutation	p.I2118V	1
ASCC3	COAD	chr6	101090570	101090570	A	C	Missense_Mutation	p.L1263W	1
ASCC3	GBM	chr6	101253737	101253737	G	T	Missense_Mutation		1
ASCC3	KIRC	chr6	101110412	101110412	C	T	Missense_Mutation	p.V763I	1
ASCC3	LIHC	chr6	101163393	101163393	T	C	Missense_Mutation	p.N699S	1
ASCC3	TGCT	chr6	101296389	101296389	G	A	Missense_Mutation		1
ASCC3	HNSC	chr6	100960612	100960612	C	T	Silent		1
ASCC3	SKCM	chr6	101075584	101075584	C	T	Missense_Mutation	p.M1508I	1
ASCC3	LGG	chr6	101296419	101296419	G	A	Nonsense_Mutation	p.R136*	1
ASCC3	STAD	chr6	101296227	101296227	G	T	Missense_Mutation	p.L200M	1
ASCC3	LIHC	chr6	101098556	101098556	A	-	Frame_Shift_Del	p.L1038fs	1
ASCC3	LUAD	chr6	100964121	100964121	C	A	Nonsense_Mutation	p.G2004*	1
ASCC3	BLCA	chr6	100957868	100957868	C	G	Missense_Mutation		1
ASCC3	BLCA	chr6	100964128	100964128	A	C	Missense_Mutation	p.H2001Q	1
ASCC3	PAAD	chr6	101073182	101073182	A	G	Silent	p.P1557P	1
ASCC3	HNSC	chr6	101054640	101054640	G	A	Missense_Mutation		1
ASCC3	BLCA	chr6	101296120	101296120	C	T	Silent		1
ASCC3	BLCA	chr6	100988255	100988255	T	C	Silent	p.E1853E	1
ASCC3	LUSC	chr6	101076979	101076979	C	T	Silent	p.E1429E	1
ASCC3	SARC	chr6	101214512	101214512	G	T	Missense_Mutation		1
ASCC3	ESCA	chr6	101095202	101095202	A	T	Silent	p.P1126P	1
ASCC3	HNSC	chr6	101215218	101215218	C	T	Missense_Mutation	p.G467R	1
ASCC3	LIHC	chr6	101312035	101312035	T	C	Missense_Mutation		1
ASCC3	STAD	chr6	101110345	101110345	C	T	Missense_Mutation	p.G785E	1
ASCC3	LIHC	chr6	101110331	101110331	C	-	Frame_Shift_Del	p.D790fs	1
ASCC3	LUAD	chr6	101214441	101214441	C	A	Missense_Mutation	p.Q579H	1
ASCC3	LIHC	chr6	101075744	101075744	G	A	Missense_Mutation	p.L1499F	1
ASCC3	UVM	chr6	101075567	101075567	C	T	Missense_Mutation		1
ASCC3	BLCA	chr6	101214545	101214545	C	T	Missense_Mutation	p.E545K	1
ASCC3	OV	chr6	101054904	101054904	T	C	Missense_Mutation	p.I1616V	1
ASCC3	COAD	chr6	101094554	101094554	A	G	Silent	p.P1190P	1
ASCC3	KIRC	chr6	101049749	101049749	T	-	Frame_Shift_Del	p.K1747fs	1
ASCC3	THCA	chr6	101253689	101253689	A	G	Missense_Mutation		1
ASCC3	HNSC	chr6	101073102	101073102	T	C	Missense_Mutation		1
ASCC3	SKCM	chr6	101053462	101053462	G	A	Missense_Mutation	p.P1720L	1
ASCC3	LGG	chr6	101086606	101086606	C	A	Missense_Mutation	p.Q1331H	1
ASCC3	STAD	chr6	100960674	100960674	G	A	Nonsense_Mutation	p.R2066X	1
ASCC3	LIHC	chr6	101110260	101110260	G	-	Frame_Shift_Del	p.A813fs	1
ASCC3	LUAD	chr6	100964120	100964120	C	A	Missense_Mutation	p.G2004V	1
ASCC3	BLCA	chr6	101312009	101312009	G	A	Silent		1
ASCC3	PRAD	chr6	101253644	101253644	G	T	Missense_Mutation	p.A305D	1
ASCC3	BLCA	chr6	101095297	101095297	C	T	Missense_Mutation		1
ASCC3	BLCA	chr6	101110332	101110332	C	T	Silent	p.Q789Q	1
ASCC3	LUSC	chr6	101296127	101296127	G	A	Missense_Mutation	p.S233L	1
ASCC3	SARC	chr6	101173498	101173498	G	T	Missense_Mutation		1
ASCC3	CESC	chr6	101095188	101095188	G	C	Nonsense_Mutation		1
ASCC3	ESCA	chr6	101315860	101315860	C	T	Missense_Mutation	p.R5H	1
ASCC3	HNSC	chr6	101307046	101307046	C	T	Missense_Mutation	p.D92N	1
ASCC3	LIHC	chr6	101253676	101253676	A	G	Silent		1
ASCC3	STAD	chr6	101049723	101049723	A	G	Missense_Mutation	p.W1756R	1
ASCC3	LIHC	chr6	101248302	101248302	T	-	Frame_Shift_Del	p.K334fs	1
ASCC3	LUAD	chr6	100960595	100960596	CC	AA	Missense_Mutation	p.G2092L	1
ASCC3	LIHC	chr6	101075734	101075735	-	AG	Frame_Shift_Ins	p.W1502fs	1
ASCC3	LUAD	chr6	101214441	101214441	C	A	Splice_Site	p.Q579_splice	1
ASCC3	BLCA	chr6	101246710	101246710	A	G	Missense_Mutation	p.I425T	1
ASCC3	OV	chr6	101165950	101165950	C	G	Splice_Site	e11+1	1
ASCC3	COAD	chr6	101166095	101166095	G	A	Silent	p.L645L	1
ASCC3	GBM	chr6	100960736	100960736	G	A	Missense_Mutation		1
ASCC3	KIRC	chr6	101173539	101173539	C	A	Missense_Mutation	p.R593I	1
ASCC3	LIHC	chr6	101095214	101095214	A	G	Silent	p.G1122G	1
ASCC3	ESCA	chr6	101095202	101095202	A	T	Silent	p.P1126	1
ASCC3	HNSC	chr6	101103624	101103624	C	T	Missense_Mutation		1
ASCC3	HNSC	chr6	101307046	101307046	C	T	Missense_Mutation		1
ASCC3	SKCM	chr6	100964096	100964096	G	A	Missense_Mutation	p.S2012F	1
ASCC3	LGG	chr6	101075864	101075864	C	A	Splice_Site		1
ASCC3	LIHC	chr6	101166078	101166078	A	-	Frame_Shift_Del	p.L651fs	1
ASCC3	LUAD	chr6	100960719	100960719	C	G	Missense_Mutation	p.E2051Q	1
ASCC3	BLCA	chr6	100964128	100964128	A	C	Missense_Mutation		1
ASCC3	BLCA	chr6	101054639	101054639	C	T	Missense_Mutation	p.R1674H	1
ASCC3	BLCA	chr6	100957932	100957932	C	T	Missense_Mutation		1
ASCC3	BLCA	chr6	101098466	101098466	C	T	Missense_Mutation	p.R1067Q	1
ASCC3	LUSC	chr6	100957342	100957342	G	C	Missense_Mutation	p.L2177V	1
ASCC3	SARC	chr6	101247341	101247341	G	T	Missense_Mutation		1
ASCC3	CESC	chr6	101312040	101312040	C	T	Nonsense_Mutation		1
ASCC3	ESCA	chr6	101103609	101103609	G	T	Missense_Mutation	p.P930Q	1
ASCC3	HNSC	chr6	101098482	101098482	G	A	Nonsense_Mutation	p.Q1062*	1
ASCC3	STAD	chr6	101053555	101053555	C	T	Missense_Mutation	p.R1689H	1
ASCC3	LUAD	chr6	101037629	101037629	C	A	Nonsense_Mutation	p.E1811*	1
ASCC3	LUAD	chr6	100965873	100965873	A	G	Missense_Mutation	p.L1974P	1
ASCC3	LIHC	chr6	101054670	101054670	C	A	Nonsense_Mutation	p.G1664X	1
ASCC3	LUAD	chr6	101248359	101248359	C	A	Missense_Mutation	p.G315V	1
ASCC3	ACC	chr6	101173535	101173535	C	G	Missense_Mutation	p.K594N	1
ASCC3	SKCM	chr6	100957860	100957860	G	A	Nonsense_Mutation	p.R2137X	1
ASCC3	COAD	chr6	101247331	101247331	T	C	Silent	p.T415T	1
ASCC3	GBM	chr6	101054729	101054729	A	G	Missense_Mutation		1
ASCC3	KIRC	chr6	101248212	101248212	A	T	Missense_Mutation	p.L364H	1
ASCC3	LIHC	chr6	100960741	100960741	T	-	Frame_Shift_Del	p.G2044fs	1
ASCC3	THYM	chr6	101247347	101247347	G	T	Missense_Mutation		1
ASCC3	HNSC	chr6	101100668	101100668	C	G	Missense_Mutation	p.G974A	1
ASCC3	SKCM	chr6	101166001	101166001	G	A	Nonsense_Mutation	p.R677*	1
ASCC3	LIHC	chr6	101163359	101163359	C	A	Missense_Mutation		1
ASCC3	LIHC	chr6	101248267	101248267	T	-	Frame_Shift_Del	p.R346fs	1
ASCC3	LUAD	chr6	100964172	100964172	C	G	Missense_Mutation	p.A1987P	1
ASCC3	PRAD	chr6	101166013	101166013	C	A	Missense_Mutation	p.D673Y	1
ASCC3	SKCM	chr6	101090562	101090562	G	A	Nonsense_Mutation	p.Q1266*	1
ASCC3	BLCA	chr6	101075843	101075843	G	T	Missense_Mutation		1
ASCC3	BLCA	chr6	101315833	101315833	G	A	Missense_Mutation	p.S14L	1
ASCC3	LUSC	chr6	101054691	101054691	C	A	Missense_Mutation	p.A1657S	1
ASCC3	SARC	chr6	101253758	101253758	T	A	Splice_Site		1
ASCC3	CESC	chr6	101095188	101095188	G	C	Nonsense_Mutation	p.S1131*	1
ASCC3	STAD	chr6	101053556	101053556	G	A	Missense_Mutation	p.R1689C	1
ASCC3	LUSC	chr6	101103640	101103640	T	C	Missense_Mutation	p.T920A	1
ASCC3	LIHC	chr6	101054671	101054671	C	A	Missense_Mutation	p.K1663N	1
ASCC3	UCEC	chr6	101173467	101173467	T	C	Missense_Mutation	p.H617R	1
ASCC3	BLCA	chr6	101073134	101073134	C	G	Missense_Mutation		1
ASCC3	SKCM	chr6	101090562	101090562	G	A	Nonsense_Mutation	p.Q1266X	1
ASCC3	COAD	chr6	101296389	101296389	G	A	Missense_Mutation	p.L146F	1
ASCC3	HNSC	chr6	101075745	101075745	G	C	Missense_Mutation		1
ASCC3	ESCA	chr6	101296336	101296336	A	-	Frame_Shift_Del	p.F163fs	1
ASCC3	HNSC	chr6	101103624	101103624	C	T	Missense_Mutation	p.R925Q	1
ASCC3	SKCM	chr6	101109679	101109682	TACC	-	Splice_Site	p.D901_splice	1
ASCC3	LIHC	chr6	101296173	101296173	T	-	Frame_Shift_Del	p.T218fs	1
ASCC3	LUAD	chr6	101095322	101095322	T	A	Silent	p.A1086A	1
ASCC3	BLCA	chr6	101054639	101054639	C	T	Missense_Mutation		1
ASCC3	READ	chr6	101110344	101110344	T	C	Silent	p.G785G	1
ASCC3	SKCM	chr6	100957841	100957841	G	A	Missense_Mutation	p.S2143F	1
ASCC3	LUSC	chr6	101095237	101095237	C	G	Missense_Mutation	p.V1115L	1
ASCC3	BLCA	chr6	101110332	101110332	C	T	Silent		1
ASCC3	BLCA	chr6	101073163	101073176	ATGAGACAAATATC	-	Frame_Shift_Del	p.LIFVSS1559fs	1
ASCC3	LUSC	chr6	101095199	101095199	C	G	Missense_Mutation	p.L1127F	1
ASCC3	SARC	chr6	101215177	101215177	G	T	Silent		1
ASCC3	CESC	chr6	101315861	101315861	G	C	Missense_Mutation	p.R5G	1
ASCC3	HNSC	chr6	101076996	101076996	T	C	Missense_Mutation	p.I1424V	1
ASCC3	LIHC	chr6	101091970	101091970	C	A	Missense_Mutation		1
ASCC3	STAD	chr6	100960674	100960674	G	A	Nonsense_Mutation	p.R2066*	1
ASCC3	THYM	chr6	101307047	101307047	C	T	Silent		1
ASCC3	LUAD	chr6	101090599	101090599	C	A	Silent	p.L1253L	1
ASCC3	LIHC	chr6	101109765	101109765	T	C	Missense_Mutation	p.S874G	1
ASCC3	LIHC	chr6	101173567	101173567	T	G	Missense_Mutation	p.T584P	1
ASCC3	UCEC	chr6	101091953	101091953	T	G	Missense_Mutation	p.N1229T	1
ASCC3	LUAD	chr6	101098455	101098455	C	G	Missense_Mutation	p.D1071H	1
ASCC3	BLCA	chr6	101248192	101248192	C	T	Missense_Mutation		1
ASCC3	BLCA	chr6	100957868	100957868	C	G	Missense_Mutation	p.G2134A	1
ASCC3	HNSC	chr6	101246603	101246603	G	T	Missense_Mutation		1
ASCC3	KIRP	chr6	101109798	101109798	C	T	Missense_Mutation	p.E863K	1
ASCC3	READ	chr6	101127606	101127606	C	T	Missense_Mutation	p.R725Q	1
ASCC3	BRCA	chr6	101166095	101166095	G	A	Silent	p.L645	1
ASCC3	HNSC	chr6	101075745	101075745	G	C	Missense_Mutation	p.D1498E	1
ASCC3	STAD	chr6	101127565	101127565	C	-	Frame_Shift_Del		1
ASCC3	LIHC	chr6	101075814	101075814	A	-	Frame_Shift_Del	p.F1475fs	1
ASCC3	BLCA	chr6	101037582	101037582	A	T	Missense_Mutation		1
ASCC3	BLCA	chr6	101307003	101307003	C	T	Missense_Mutation	p.R106K	1
ASCC3	THYM	chr6	101076918	101076918	G	T	Missense_Mutation		1
ASCC3	LUAD	chr6	101075586	101075586	T	G	Splice_Site	p.M1508_splice	1
ASCC3	LUSC	chr6	101311979	101311979	C	T	Missense_Mutation	p.E68K	1
ASCC3	BLCA	chr6	101098466	101098466	C	T	Missense_Mutation		1
ASCC3	MESO	chr6	101090583	101090583	T	A	Missense_Mutation		1
ASCC3	SARC	chr6	101086515	101086515	C	T	Missense_Mutation		1
ASCC3	CHOL	chr6	101100758	101100758	G	C	Missense_Mutation		1
ASCC3	GBM	chr6	101054729	101054729	A	G	Missense_Mutation	p.I1644T	1
ASCC3	HNSC	chr6	101037825	101037825	T	A	Missense_Mutation	p.E1805V	1
ASCC3	STAD	chr6	101296505	101296506	AC	-	Frame_Shift_Del	p.107_107del	1
ASCC3	LIHC	chr6	101253728	101253728	A	G	Missense_Mutation		1
ASCC3	STAD	chr6	101077033	101077033	C	T	Silent	p.V1411V	1
ASCC3	SKCM	chr6	100957956	100957956	G	A	Missense_Mutation	p.P2105S	1
ASCC3	LIHC	chr6	101095306	101095306	C	T	Missense_Mutation	p.A1092T	1
ASCC3	BLCA	chr6	101103664	101103664	C	G	Missense_Mutation		1
ASCC3	BLCA	chr6	101296316	101296316	G	T	Nonsense_Mutation	p.S170*	1
ASCC3	PAAD	chr6	101073182	101073182	A	G	Silent		1
ASCC3	COAD	chr6	101315861	101315861	G	A	Missense_Mutation	p.R5C	1
ASCC3	HNSC	chr6	101100668	101100668	C	G	Missense_Mutation		1
ASCC3	CESC	chr6	101100745	101100745	C	T	Silent		1
ASCC3	ESCA	chr6	100988137	100988137	G	T	Missense_Mutation		1
ASCC3	HNSC	chr6	101215068	101215068	T	A	Missense_Mutation	p.I517F	1
ASCC3	STAD	chr6	101127558	101127558	T	-	Frame_Shift_Del		1
ASCC3	LIHC	chr6	101296057	101296057	A	G	Silent		1
ASCC3	LIHC	chr6	101098542	101098542	A	-	Frame_Shift_Del	p.C1042fs	1
ASCC3	LUAD	chr6	101307034	101307034	C	A	Nonsense_Mutation	p.E96*	1
ASCC3	BLCA	chr6	101214503	101214503	T	C	Missense_Mutation		1
ASCC3	THYM	chr6	100960643	100960643	G	A	Missense_Mutation		1
ASCC3	BLCA	chr6	101073163	101073176	ATGAGACAAATATC	-	Frame_Shift_Del		1
ASCC3	MESO	chr6	101090583	101090583	T	A	Missense_Mutation	p.I1259F	1
ASCC3	SARC	chr6	100957312	100957312	G	T	Missense_Mutation		1
ASCC3	GBM	chr6	101110219	101110219	A	T	Splice_Site	p.K826_splice	1
ASCC3	KICH	chr6	101127578	101127578	A	G	Silent		1
ASCC3	STAD	chr6	101296172	101296173	-	T	Frame_Shift_Ins	p.T218fs	1
ASCC3	LIHC	chr6	101099463	101099463	G	T	Silent		1
ASCC3	STAD	chr6	101248368	101248368	T	G	Missense_Mutation	p.K312T	1
ASCC3	BLCA	chr6	101214545	101214545	C	T	Missense_Mutation		1
ASCC3	BLCA	chr6	101312009	101312009	G	A	Silent	p.L58L	1
ASCC3	PAAD	chr6	101296418	101296418	C	A	Missense_Mutation		1
ASCC3	COAD	chr6	100960736	100960736	G	A	Missense_Mutation	p.S2045L	1
ASCC3	HNSC	chr6	101037825	101037825	T	A	Missense_Mutation		1
ASCC3	LUSC	chr6	101095150	101095150	T	A	Nonsense_Mutation	p.K1144*	1
ASCC3	READ	chr6	101110342	101110342	A	T	Missense_Mutation	p.M786K	1
ASCC3	CESC	chr6	101091942	101091942	A	G	Missense_Mutation		1
ASCC3	LIHC	chr6	100965968	100965968	A	G	Silent		1
ASCC3	LIHC	chr6	101100721	101100721	T	-	Frame_Shift_Del	p.E956fs	1
ASCC3	BLCA	chr6	101098465	101098465	T	A	Silent		1
ASCC3	BLCA	chr6	101095297	101095297	C	T	Missense_Mutation	p.E1095K	1
ASCC3	THYM	chr6	101248318	101248318	G	T	Missense_Mutation	p.Q329K	1
ASCC3	BLCA	chr6	101315833	101315833	G	A	Missense_Mutation		1
ASCC3	MESO	chr6	100960766	100960772	ACTGGCA	-	Frame_Shift_Del	p.LPV2033fs	1
ASCC3	COAD	chr6	100964147	100964147	G	C	Missense_Mutation	p.S1995C	1
ASCC3	GBM	chr6	101073206	101073206	A	G	Silent	p.I1549I	1
ASCC3	KIRC	chr6	101054679	101054679	T	C	Missense_Mutation	p.I1661V	1
ASCC3	STAD	chr6	101315870	101315870	C	A	Missense_Mutation	p.A2S	1
ASCC3	SKCM	chr6	101315838	101315838	G	A	Silent	p.S12S	1
ASCC3	KIRP	chr6	101296249	101296249	T	A	Silent		1
ASCC3	UCEC	chr6	101296335	101296336	-	A	Frame_Shift_Ins	p.F163fs	1
ASCC3	BLCA	chr6	101246710	101246710	A	G	Missense_Mutation		1
ASCC3	BLCA	chr6	101248283	101248283	A	C	Nonsense_Mutation	p.Y340*	1
ASCC3	COAD	chr6	101053552	101053552	G	A	Missense_Mutation	p.A1690V	1
ASCC3	HNSC	chr6	101296082	101296082	C	G	Missense_Mutation		1
ASCC3	LUSC	chr6	100988080	100988080	C	G	Missense_Mutation	p.D1912H	1
ASCC3	READ	chr6	101214448	101214448	C	T	Missense_Mutation	p.R577Q	1
ASCC3	CESC	chr6	100957344	100957344	T	C	Missense_Mutation		1
ASCC3	ESCA	chr6	101095202	101095202	A	T	Silent		1
ASCC3	HNSC	chr6	101073102	101073102	T	C	Missense_Mutation	p.D1584G	1
ASCC3	LIHC	chr6	101109765	101109765	T	C	Missense_Mutation		1
ASCC3	LIHC	chr6	101296196	101296196	G	-	Frame_Shift_Del	p.P210fs	1
ASCC3	LUAD	chr6	101090536	101090536	A	T	Missense_Mutation	p.D1274E	1
ASCC3	BLCA	chr6	101307003	101307003	C	T	Missense_Mutation		1
ASCC3	LIHC	chr6	101073148	101073148	G	A	Missense_Mutation	p.R1569C	1
ASCC3	THYM	chr6	100960643	100960643	G	A	Missense_Mutation	p.A2076V	1
ASCC3	BLCA	chr6	101073134	101073134	C	G	Missense_Mutation	p.L1573F	1
ASCC3	OV	chr6	101072612	101072612	T	C	Missense_Mutation		1
ASCC3	SARC	chr6	101075758	101075758	G	T	Missense_Mutation	p.A1494D	1
ASCC3	COAD	chr6	101075489	101075489	C	T	Missense_Mutation	p.S1540N	1
ASCC3	GBM	chr6	101109901	101109901	T	C	Silent		1
ASCC3	LIHC	chr6	101247376	101247376	T	C	Missense_Mutation	p.I400M	1
ASCC3	STAD	chr6	101296505	101296506	AC	-	Frame_Shift_Del	p.V107fs	1
ASCC3	SKCM	chr6	101090585	101090585	G	A	Missense_Mutation	p.P1258L	1
ASCC3	LGG	chr6	100957869	100957869	C	G	Missense_Mutation	p.G2134R	1
ASCC3	LIHC	chr6	100957936	100957936	T	-	Frame_Shift_Del	p.K2111fs	1
ASCC3	LUAD	chr6	100960596	100960596	C	A	Missense_Mutation	p.G2092W	1
ASCC3	BLCA	chr6	100966000	100966000	C	T	Missense_Mutation		1
ASCC3	COAD	chr6	101073184	101073184	G	T	Missense_Mutation	p.P1557T	1
ASCC3	HNSC	chr6	101215068	101215068	T	A	Missense_Mutation		1
ASCC3	LUSC	chr6	101296201	101296201	G	A	Silent	p.C208C	1
ASCC3	READ	chr6	101248365	101248365	A	T	Missense_Mutation	p.I313N	1
ASCC3	HNSC	chr6	101037825	101037825	T	A	Splice_Site	p.E1805_splice	1
ASCC3	STAD	chr6	101092001	101092001	T	G	Missense_Mutation		1
ASCC3	LIHC	chr6	101214514	101214514	T	C	Missense_Mutation		1
ASCC3	STAD	chr6	101092001	101092001	T	G	Missense_Mutation	p.H1213P	1
ASCC3	LIHC	chr6	100960741	100960741	T	-	Frame_Shift_Del	p.K2043fs	1
ASCC3	LUAD	chr6	101095196	101095196	T	A	Missense_Mutation	p.R1128S	1
ASCC3	BLCA	chr6	101103593	101103593	G	A	Silent		1
ASCC3	BLCA	chr6	101075843	101075843	G	T	Missense_Mutation	p.L1466I	1
ASCC3	LIHC	chr6	101312035	101312035	T	C	Missense_Mutation	p.K49R	1
ASCC3	THYM	chr6	101247347	101247347	G	T	Missense_Mutation	p.A410D	1
ASCC3	LUAD	chr6	101166053	101166053	T	A	Silent	p.T659T	1
ASCC3	UCS	chr6	101248328	101248328	T	G	Missense_Mutation		1
ASCC3	BLCA	chr6	101248192	101248192	C	T	Missense_Mutation	p.E371K	1
ASCC3	OV	chr6	101248260	101248260	G	A	Missense_Mutation	p.A348V	1
ASCC3	SARC	chr6	101253758	101253758	T	A	Splice_Site	e4-2	1
ASCC3	COAD	chr6	101086481	101086481	G	T	Nonsense_Mutation	p.S1373X	1
ASCC3	GBM	chr6	101073206	101073206	A	G	Silent		1
ASCC3	KIRC	chr6	101166054	101166054	G	C	Missense_Mutation	p.T659R	1
ASCC3	TGCT	chr6	101166095	101166095	G	A	Silent		1

Copy number variation (CNV) of ASCC3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ASCC3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97494	SARC	TCGA-HB-A3YV	AKAP12	chr6	151561859	+	ASCC3	chr6	100988263	-
97494	SARC	TCGA-HB-A3YV-01A	AKAP12	chr6	151561859	+	ASCC3	chr6	101037935	-
97494	N/A	DA153697	ARL15	chr5	53409032	-	ASCC3	chr6	101054966	-
79266	BRCA	TCGA-A8-A06T-01A	ASCC3	chr6	101053444	-	ATL1	chr14	51094749	+
99091	STAD	TCGA-D7-A4Z0-01A	ASCC3	chr6	101311940	-	GPBP1L1	chr1	46106075	-
79075	BRCA	TCGA-AN-A0AM-01A	ASCC3	chr6	101214440	-	GRIK2	chr6	102247522	+
79075	BRCA	TCGA-AN-A0AM-01A	ASCC3	chr6	101214441	-	GRIK2	chr6	102192474	+
79075	BRCA	TCGA-AN-A0AM-01A	ASCC3	chr6	101214441	-	GRIK2	chr6	102247523	+
79075	BRCA	TCGA-E9-A248-01A	ASCC3	chr6	100978082	-	GRIK2	chr6	102250312	-
79075	BRCA	TCGA-E9-A248-01A	ASCC3	chr6	101052506	-	GRIK2	chr6	102250312	-
79075	UCEC	TCGA-EY-A3QX-01A	ASCC3	chr6	101037509	-	GRIK2	chr6	101864082	-
93667	ESCA	TCGA-2H-A9GJ	ASCC3	chr6	101328936	-	ITPK1	chr14	93483146	-
102286	N/A	AI359004	ASCC3	chr6	100994386	+	NEAT1	chr11	65198575	-
101007	BRCA	TCGA-E9-A248-01A	ASCC3	chr6	101308910	-	PLEKHG1	chr6	151031975	-
100540	LGG	TCGA-E1-5304-01A	ASCC3	chr6	101163338	-	SERINC1	chr6	122768149	-
68526	LUSC	TCGA-85-7843-01A	ASCC3	chr6	101037510	-	SIM1	chr6	100901720	-
100932	PRAD	TCGA-VP-A87C-01A	ASCC3	chr6	101315784	-	SYNE1	chr6	152563575	-
72906	Non-Cancer	211N	ASCC3	chr6	101311939	-	TMEM30A	chr6	75977464	-
101773	READ	TCGA-AH-6644-01A	ASCC3	chr6	100988039	-	TPD52L1	chr6	125541224	+
79126	ACC	TCGA-OR-A5JY-01A	ASCC3	chr6	101052507	-	TXNRD2	chr22	19929420	-
97040	SARC	TCGA-HB-A3YV-01A	ASCC3	chr6	101315784	-	WASF1	chr6	110448832	-
97494	PAAD	TCGA-L1-A7W4-01A	FAXC	chr6	99790774	-	ASCC3	chr6	100960794	-
97494	PRAD	TCGA-KK-A8ID-01A	FAXC	chr6	99796983	-	ASCC3	chr6	100988263	-
97494	BRCA	TCGA-AR-A1AJ-01A	FBXL4	chr6	99395682	-	ASCC3	chr6	101315914	-
97494	LUSC	TCGA-46-6026-01A	HACE1	chr6	105291098	-	ASCC3	chr6	101312090	-
97494	BRCA	TCGA-BH-A1F0-01A	HIVEP3	chr1	42094420	-	ASCC3	chr6	101054964	-
97494	LIHC	TCGA-CC-A8HV-01A	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
97494	GBM	TCGA-27-2526	OTUD7A	chr15	31862220	-	ASCC3	chr6	100988263	-
97494	GBM	TCGA-27-2526-01A	OTUD7A	chr15	31862221	-	ASCC3	chr6	100988263	-
97494	STAD	TCGA-CD-A486	PNISR	chr6	99873090	-	ASCC3	chr6	101054964	-
97494	STAD	TCGA-CD-A486-01A	PNISR	chr6	99873091	-	ASCC3	chr6	101054964	-
97494	BRCA	TCGA-BH-A0BO-01A	PPP2R5D	chr6	42957426	+	ASCC3	chr6	101215221	-
97494	STAD	TCGA-HU-A4G2	REV3L	chr6	111803952	-	ASCC3	chr6	101253756	-
97494	LUAD	TCGA-69-7760-01A	SIM1	chr6	100868666	-	ASCC3	chr6	100988263	-
97494	Non-Cancer	TCGA-BQ-7046-11A	UBE4B	chr1	10093752	+	ASCC3	chr6	101127628	-
97497	LIHC	TCGA-ZP-A9D0-01A	USP45	chr6	99912480	-	ASCC3	chr6	100988263	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	ASCC3	0.00185795240717193	0.052
KIRP	ASCC3	0.00260224950188084	0.07

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	ASCC3	0.0115731284661171	0.38

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0020796	Profound Mental Retardation	1	CTD_human
C0917816	Mental deficiency	1	CTD_human