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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TRIM71 (NCBI Gene ID:131405)

Gene Summary

Gene Summary

Gene Information	Gene Name: TRIM71
	Gene ID: 131405
	Gene Symbol	TRIM71
	Gene ID	131405
	Gene Name	tripartite motif containing 71
	Synonyms	HYDCC1\|LIN-41\|LIN41
	Cytomap	3p22.3
	Type of Gene	protein-coding
	Description	E3 ubiquitin-protein ligase TRIM71RING-type E3 ubiquitin transferase TRIM71abnormal cell LINeage LIN-41homolog of C. elegans Lin-41protein lin-41 homologtripartite motif containing 71, E3 ubiquitin protein ligasetripartite motif-containing protein 7
	Modification date	20200313
	UniProtAcc	Q2Q1W2

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRIM71	GO:0017148	negative regulation of translation	23125361
Hgene	TRIM71	GO:0061158	3'-UTR-mediated mRNA destabilization	23125361

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TRIM71	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'TRIM71[title] AND translation [title] AND human.'

Gene	Title	PMID
TRIM71	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	TRIM71	-1.72374332356924	0.000294681332419049
KIRP	TRIM71	-1.87622711327744	0.00527895997429013
LUAD	TRIM71	-5.14884793069944	8.51355532875163e-11

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CHOL	TRIM71	hsa-miR-125b-5p	98	-0.347203247428495	0.0194504280873793
CHOL	TRIM71	hsa-miR-409-3p	71	0.444627802600538	0.00221296910195471

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LAML	TRIM71	2	3	0.00623200527331237	0.534197719298246	0.627010217391304	-0.725710306634881	-1.07696695550304
SARC	TRIM71	2	3	0.0411018877853632	0.512364800242131	0.639946608946609	-0.0124947005295177	0.286714467421519

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
READ	TRIM71	3	2	0.0450856414391119	0.654752976704055	0.53764	0.898711247703982	0.672307823296838

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THYM	TRIM71	-0.309392664	0.002091868

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TRIM71 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	TRIM71	TSHB	0.860989629	3.31E-14
CHOL	CGC	TRIM71	DCC	0.820796558	5.09E-12
CHOL	IUPHAR	TRIM71	GABRR3	0.937780507	2.27E-21
CHOL	TF	TRIM71	NKX2-4	0.937780507	2.27E-21
CHOL	TSG	TRIM71	DCC	0.820796558	5.09E-12
DLBC	Cell metabolism gene	TRIM71	PLA2G4E	0.808477203	3.67E-12
DLBC	IUPHAR	TRIM71	PLA2G4E	0.808477203	3.67E-12
KICH	Cell metabolism gene	TRIM71	NT5C1A	0.891820586	2.07E-32
KICH	IUPHAR	TRIM71	ILDR2	0.837457628	4.43E-25
KICH	IUPHAR	TRIM71	NT5C1A	0.891820586	2.07E-32
TGCT	CGC	TRIM71	STIL	0.813519738	4.37E-38
TGCT	CGC	TRIM71	TET1	0.830886245	4.80E-41
TGCT	CGC	TRIM71	SALL4	0.855834527	6.08E-46
TGCT	Epifactor	TRIM71	TET1	0.830886245	4.80E-41
TGCT	Epifactor	TRIM71	CECR2	0.835990355	5.59E-42
TGCT	IUPHAR	TRIM71	CECR2	0.835990355	5.59E-42
TGCT	TF	TRIM71	ZNF675	0.801151306	3.68E-36
TGCT	TF	TRIM71	TET1	0.830886245	4.80E-41
TGCT	TF	TRIM71	ARID3B	0.850938421	6.53E-45
TGCT	TF	TRIM71	SALL4	0.855834527	6.08E-46
TGCT	TSG	TRIM71	SALL4	0.855834527	6.08E-46

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
PRAD	TRIM71	BBOX1	1.02923298127203	0.000931746432967977
HNSC	TRIM71	LIN28B	-3.637237905407	0.0023768350959738
CHOL	TRIM71	BBOX1	-2.14659282621794	0.0078125
CHOL	TRIM71	ZNF362	-3.14254900339506	0.01171875
PRAD	TRIM71	DICER1	1.54768558737379	0.0130781232419534
BLCA	TRIM71	CAPN3	1.21852989649077	0.0289306640625
KIRP	TRIM71	TRAT1	-1.97055765544983	0.0453950124792755
LIHC	TRIM71	BBOX1	-1.53811873130105	2.28054594243154e-08
LUSC	TRIM71	TRAT1	-1.86136489009036	5.45378040851963e-05
THCA	TRIM71	BBOX1	-1.15213579453948	6.18215597921662e-07
LUAD	TRIM71	LIN28B	-1.96723920023194	9.56917315705946e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TRIM71

LIN28B, AGO2, DICER1, LIN28A, HIST1H1A, THAP2, TRAK2, E4F1, WDR46, SYCE3, CDX1, RRS1, ZNF324B, HIST1H1E, FGF8, RSBN1, GLTSCR2, EZH2, TP53, MIRLET7F2, MIR1-1, MIR1-2, MIR15A, MIR18B, MIR25, MIR29A, MIR29B1, MIR155, MIR100, N, CDKN1A, UPF1, SMG1, DCP1A, SMG7, FGF13, CCDC140, THAP3, SURF6, RPL35, KRR1, RPS3, HIST1H1C, ZNF346, PRR3, YBX2, RPL31, YBX1, PURG, RPL19, PABPC5, ZNF467, SRSF4, RPS16, ZNF668, CBX6, RPL26, IGF2BP1, DHX9,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TRIM71	chr3	32859791	C	CCGGCTGCCGGCGGCGGG	Duplication	Likely_pathogenic	Non-obstructive_azoospermia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TRIM71	chr3	32859809	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRIM71	chr3	32859820	C	T	single_nucleotide_variant	Uncertain_significance	Cryptozoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32859940	T	C	single_nucleotide_variant	Uncertain_significance	Cryptozoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32860125	G	T	single_nucleotide_variant	Likely_benign	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32860357	G	C	single_nucleotide_variant	Likely_benign	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32860375	T	A	single_nucleotide_variant	Uncertain_significance	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32915303	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TRIM71	chr3	32927475	C	T	single_nucleotide_variant	Uncertain_significance	Cryptozoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32932182	C	T	single_nucleotide_variant	Uncertain_significance	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32932245	C	T	single_nucleotide_variant	Uncertain_significance	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32932309	C	G	single_nucleotide_variant	Uncertain_significance	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32932485	G	A	single_nucleotide_variant	Uncertain_significance	Non-obstructive_azoospermia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32932519	G	A	single_nucleotide_variant	Pathogenic	Hydrocephalus,_congenital_communicating,_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32932582	G	A	single_nucleotide_variant	Likely_pathogenic	Congenital_hydrocephalus	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32933006	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRIM71	chr3	32933083	G	A	single_nucleotide_variant	Pathogenic	Hydrocephalus,_congenital_communicating,_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TRIM71	chr3	32933129	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TRIM71	chr3	32933146	G	A	single_nucleotide_variant	Likely_pathogenic	Congenital_hydrocephalus	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TRIM71	STAD	chr3	32933115	32933115	C	T	Missense_Mutation	p.R807C	5
TRIM71	LIHC	chr3	32915309	32915309	G	A	Splice_Site		5
TRIM71	LUAD	chr3	32860298	32860298	G	T	Silent	p.P242P	5
TRIM71	SKCM	chr3	32932742	32932742	C	T	Silent	p.F682F	5
TRIM71	GBM	chr3	32932739	32932739	G	A	Silent	p.T681T	4
TRIM71	SKCM	chr3	32932942	32932942	C	T	Missense_Mutation	p.S749F	4
TRIM71	BRCA	chr3	32932211	32932211	C	A	Missense_Mutation	p.F505L	4
TRIM71	BRCA	chr3	32933156	32933156	G	T	Missense_Mutation	p.M820I	4
TRIM71	BRCA	chr3	32933232	32933232	G	A	Missense_Mutation	p.G846S	3
TRIM71	UCEC	chr3	32932439	32932439	G	T	Missense_Mutation	p.K581N	3
TRIM71	PRAD	chr3	32932570	32932570	G	A	Missense_Mutation	p.R625H	3
TRIM71	UCEC	chr3	32915422	32915422	G	A	Missense_Mutation	p.R322Q	3
TRIM71	SKCM	chr3	32932943	32932943	C	T	Silent	p.S749S	3
TRIM71	HNSC	chr3	32932010	32932010	G	T	Silent	p.L438L	3
TRIM71	SKCM	chr3	32933287	32933287	G	A	Missense_Mutation	p.R864Q	3
TRIM71	ESCA	chr3	32931919	32931919	T	C	Missense_Mutation	p.L408P	3
TRIM71	READ	chr3	32932655	32932655	C	T	Silent	p.F653F	3
TRIM71	COAD	chr3	32931948	32931948	G	A	Missense_Mutation	p.V418M	3
TRIM71	LUAD	chr3	32933145	32933145	C	T	Missense_Mutation	p.R817W	3
TRIM71	LGG	chr3	32927435	32927435	G	A	Missense_Mutation	p.E344K	3
TRIM71	SKCM	chr3	32932556	32932556	C	T	Silent	p.I620I	2
TRIM71	STAD	chr3	32860312	32860312	C	T	Missense_Mutation	p.A247V	2
TRIM71	LGG	chr3	32932670	32932670	C	T	Silent		2
TRIM71	PRAD	chr3	32933082	32933082	C	T	Missense_Mutation	p.R796C	2
TRIM71	SARC	chr3	32933059	32933059	G	A	Missense_Mutation	p.G788D	2
TRIM71	SKCM	chr3	32915324	32915324	C	T	Silent	p.Y289Y	2
TRIM71	STAD	chr3	32932136	32932136	C	T	Silent	p.S480S	2
TRIM71	LIHC	chr3	32933199	32933199	G	-	Frame_Shift_Del	p.G835fs	2
TRIM71	SKCM	chr3	32927434	32927434	C	T	Silent	p.I343I	2
TRIM71	CESC	chr3	32915372	32915372	G	A	Silent		2
TRIM71	HNSC	chr3	32933213	32933213	G	A	Silent	p.G839G	2
TRIM71	LIHC	chr3	32932464	32932464	G	-	Frame_Shift_Del	p.G590fs	2
TRIM71	SKCM	chr3	32859584	32859584	C	T	Silent	p.F4F	2
TRIM71	STAD	chr3	32932581	32932581	C	T	Missense_Mutation	p.R629C	2
TRIM71	STAD	chr3	32932038	32932038	C	T	Missense_Mutation		2
TRIM71	STAD	chr3	32859644	32859644	G	A	Silent	p.P24P	2
TRIM71	CESC	chr3	32915396	32915396	C	T	Silent		2
TRIM71	PRAD	chr3	32932438	32932438	A	T	Missense_Mutation	p.K581M	2
TRIM71	SKCM	chr3	32931962	32931962	G	A	Silent	p.L422L	2
TRIM71	STAD	chr3	32859684	32859684	A	T	Missense_Mutation	p.T38S	2
TRIM71	UCEC	chr3	32915329	32915329	A	G	Missense_Mutation	p.D291G	2
TRIM71	GBM	chr3	32932739	32932739	G	A	Silent		2
TRIM71	STAD	chr3	32932742	32932742	C	T	Silent		2
TRIM71	STAD	chr3	32860324	32860324	C	T	Missense_Mutation	p.A251V	2
TRIM71	HNSC	chr3	32931915	32931915	A	C	Missense_Mutation	p.N407H	2
TRIM71	COAD	chr3	32933286	32933286	C	T	Nonsense_Mutation	p.R864X	2
TRIM71	UCEC	chr3	32927530	32927530	G	-	Frame_Shift_Del	p.E376fs	2
TRIM71	BLCA	chr3	32932040	32932040	G	A	Silent	p.R448R	2
TRIM71	STAD	chr3	32933178	32933178	C	A	Missense_Mutation		2
TRIM71	STAD	chr3	32932608	32932608	G	A	Missense_Mutation	p.A638T	2
TRIM71	COAD	chr3	32859629	32859629	C	T	Silent	p.C19C	2
TRIM71	HNSC	chr3	32933083	32933083	G	A	Missense_Mutation	p.R796H	2
TRIM71	UCEC	chr3	32927537	32927537	C	T	Missense_Mutation	p.R378C	2
TRIM71	SKCM	chr3	32932199	32932199	G	A	Silent	p.K501K	2
TRIM71	SKCM	chr3	32931959	32931959	C	T	Silent	p.V421V	2
TRIM71	STAD	chr3	32932035	32932035	G	A	Missense_Mutation	p.V447M	2
TRIM71	STAD	chr3	32932065	32932065	G	A	Missense_Mutation	p.D457N	2
TRIM71	COAD	chr3	32927475	32927475	C	T	Missense_Mutation	p.A357V	2
TRIM71	LUAD	chr3	32932170	32932170	G	A	Missense_Mutation	p.D492N	2
TRIM71	BLCA	chr3	32927521	32927521	G	A	Silent	p.K372K	2
TRIM71	LGG	chr3	32932670	32932670	C	T	Silent	p.G658G	2
TRIM71	UCEC	chr3	32932414	32932414	A	G	Missense_Mutation	p.N573S	2
TRIM71	LIHC	chr3	32932714	32932714	A	G	Missense_Mutation		2
TRIM71	SKCM	chr3	32932694	32932694	G	A	Silent	p.R666R	2
TRIM71	STAD	chr3	32933178	32933178	C	A	Missense_Mutation	p.L828M	2
TRIM71	STAD	chr3	32860361	32860361	G	A	Silent	p.P263P	2
TRIM71	KIRC	chr3	32932071	32932071	G	C	Missense_Mutation	p.V459L	2
TRIM71	BLCA	chr3	32932410	32932410	G	C	Missense_Mutation	p.E572Q	2
TRIM71	ESCA	chr3	32932582	32932582	G	C	Missense_Mutation	p.R629P	2
TRIM71	UCEC	chr3	32932742	32932742	C	T	Silent	p.F682	2
TRIM71	LIHC	chr3	32932669	32932669	G	A	Missense_Mutation		2
TRIM71	SKCM	chr3	32933161	32933161	A	T	Missense_Mutation	p.E822V	2
TRIM71	SKCM	chr3	32932358	32932358	C	T	Silent	p.P554P	2
TRIM71	STAD	chr3	32932038	32932038	C	T	Missense_Mutation	p.R448W	2
TRIM71	STAD	chr3	32860341	32860341	G	A	Missense_Mutation	p.G257R	2
TRIM71	BLCA	chr3	32933231	32933231	C	T	Silent	p.S845S	2
TRIM71	UCEC	chr3	32933128	32933128	C	T	Missense_Mutation	p.A811V	2
TRIM71	LIHC	chr3	32915309	32915309	G	A	Splice_Site	.	2
TRIM71	SKCM	chr3	32933207	32933207	C	G	Silent	p.G837G	2
TRIM71	STAD	chr3	32932852	32932852	C	T	Missense_Mutation	p.T719M	2
TRIM71	LUAD	chr3	32932777	32932777	G	A	Missense_Mutation	p.G694E	2
TRIM71	PCPG	chr3	32932862	32932862	C	T	Silent		2
TRIM71	SARC	chr3	32933059	32933059	G	A	Missense_Mutation		2
TRIM71	UCEC	chr3	32933261	32933261	C	T	Silent	p.I855	2
TRIM71	LIHC	chr3	32932669	32932669	G	A	Missense_Mutation	p.G658D	2
TRIM71	SKCM	chr3	32932868	32932868	C	T	Silent	p.I724I	2
TRIM71	STAD	chr3	32860404	32860404	T	A	Missense_Mutation	p.C278S	2
TRIM71	STAD	chr3	32932496	32932496	T	C	Silent	p.G600G	2
TRIM71	PCPG	chr3	32932862	32932862	C	T	Silent	p.H722H	2
TRIM71	SARC	chr3	32932838	32932838	C	T	Silent		2
TRIM71	SKCM	chr3	32932625	32932625	C	T	Silent	p.F643F	2
TRIM71	SKCM	chr3	32927476	32927476	G	A	Silent	p.A357A	2
TRIM71	LUAD	chr3	32859640	32859640	C	G	Missense_Mutation	p.A23G	1
TRIM71	BLCA	chr3	32932942	32932942	C	A	Missense_Mutation		1
TRIM71	COAD	chr3	32932642	32932642	G	A	Missense_Mutation	p.R649Q	1
TRIM71	KIRP	chr3	32860208	32860208	C	T	Silent	p.C212C	1
TRIM71	STAD	chr3	32932421	32932422	-	A	Frame_Shift_Ins	p.P575fs	1
TRIM71	BLCA	chr3	32860419	32860419	G	C	Missense_Mutation	p.D283H	1
TRIM71	ESCA	chr3	32927511	32927511	C	T	Missense_Mutation	p.A369V	1
TRIM71	SKCM	chr3	32915402	32915402	G	A	Silent	p.Q315Q	1
TRIM71	SKCM	chr3	32932587	32932587	C	T	Nonsense_Mutation	p.Q631*	1
TRIM71	GBM	chr3	32860416	32860416	G	A	Missense_Mutation		1
TRIM71	HNSC	chr3	32933123	32933123	T	C	Silent	p.I809I	1
TRIM71	KIRP	chr3	32932124	32932124	C	T	Silent	p.G476G	1
TRIM71	LUAD	chr3	32933250	32933250	G	T	Missense_Mutation	p.D852Y	1
TRIM71	BLCA	chr3	32932318	32932318	G	C	Missense_Mutation		1
TRIM71	COAD	chr3	32932939	32932939	A	T	Missense_Mutation	p.D748V	1
TRIM71	BLCA	chr3	32932942	32932942	C	A	Missense_Mutation	p.S749Y	1
TRIM71	ESCA	chr3	32932232	32932232	C	T	Silent	p.H512H	1
TRIM71	LGG	chr3	32927435	32927435	G	A	Missense_Mutation		1
TRIM71	SARC	chr3	32915368	32915368	G	T	Missense_Mutation	p.G304V	1
TRIM71	SKCM	chr3	32932809	32932809	G	A	Missense_Mutation	p.D705N	1
TRIM71	SKCM	chr3	32932869	32932869	C	T	Nonsense_Mutation	p.Q725X	1
TRIM71	STAD	chr3	32932035	32932035	G	A	Missense_Mutation		1
TRIM71	STAD	chr3	32915308	32915308	A	G	Splice_Site	.	1
TRIM71	GBM	chr3	32933302	32933302	A	G	Silent		1
TRIM71	KIRP	chr3	32915387	32915387	C	A	Missense_Mutation	p.S310R	1
TRIM71	LUAD	chr3	32933216	32933216	G	A	Silent	p.Q840Q	1
TRIM71	BLCA	chr3	32932722	32932722	C	T	Missense_Mutation		1
TRIM71	COAD	chr3	32933066	32933066	C	A	Silent	p.G790G	1
TRIM71	BLCA	chr3	32932318	32932318	G	C	Missense_Mutation	p.S541T	1
TRIM71	ESCA	chr3	32932232	32932232	C	T	Silent		1
TRIM71	LGG	chr3	32932723	32932723	G	A	Missense_Mutation		1
TRIM71	SARC	chr3	32932838	32932838	C	T	Silent	p.I714I	1
TRIM71	SKCM	chr3	32932357	32932357	C	T	Missense_Mutation	p.P554L	1
TRIM71	LIHC	chr3	32860383	32860383	T	-	Frame_Shift_Del	p.F271fs	1
TRIM71	KIRP	chr3	32932925	32932925	C	A	Silent		1
TRIM71	LUSC	chr3	32933223	32933223	C	T	Missense_Mutation	p.R843C	1
TRIM71	BLCA	chr3	32932040	32932040	G	A	Silent		1
TRIM71	COAD	chr3	32933116	32933116	G	A	Missense_Mutation	p.R807H	1
TRIM71	BLCA	chr3	32932722	32932722	C	T	Missense_Mutation	p.R676C	1
TRIM71	GBM	chr3	32933041	32933041	G	A	Missense_Mutation	p.R782H	1
TRIM71	LGG	chr3	32932914	32932914	G	A	Missense_Mutation		1
TRIM71	SARC	chr3	32932042	32932042	G	T	Missense_Mutation		1
TRIM71	SKCM	chr3	32932856	32932856	G	A	Silent	p.R720R	1
TRIM71	CESC	chr3	32915396	32915396	C	T	Silent	p.Y313	1
TRIM71	LUAD	chr3	32933097	32933097	G	T	Missense_Mutation	p.A801S	1
TRIM71	KIRP	chr3	32932841	32932841	G	A	Silent		1
TRIM71	MESO	chr3	32915338	32915338	C	A	Missense_Mutation		1
TRIM71	PRAD	chr3	32915352	32915352	C	A	Missense_Mutation	p.R299S	1
TRIM71	SKCM	chr3	32915400	32915400	C	T	Nonsense_Mutation	p.Q315*	1
TRIM71	STAD	chr3	32915308	32915308	A	G	Splice_Site	p.V285_splice	1
TRIM71	BLCA	chr3	32932092	32932092	C	G	Missense_Mutation		1
TRIM71	GBM	chr3	32859692	32859692	G	A	Silent	p.T40T	1
TRIM71	HNSC	chr3	32933123	32933123	T	C	Silent		1
TRIM71	SARC	chr3	32932838	32932838	C	T	Silent	p.I714	1
TRIM71	SKCM	chr3	32933286	32933286	C	T	Nonsense_Mutation	p.R864*	1
TRIM71	SKCM	chr3	32915400	32915400	C	T	Nonsense_Mutation	p.Q315X	1
TRIM71	ACC	chr3	32932887	32932887	G	T	Missense_Mutation	p.G731C	1
TRIM71	BLCA	chr3	32915444	32915444	G	A	Silent		1
TRIM71	KIRP	chr3	32915387	32915387	C	A	Missense_Mutation		1
TRIM71	OV	chr3	32907173	32907173	C	T	Silent		1
TRIM71	READ	chr3	32932173	32932173	G	T	Missense_Mutation	p.G493C	1
TRIM71	SKCM	chr3	32932865	32932865	G	A	Silent	p.R723R	1
TRIM71	STAD	chr3	32859686	32859686	G	A	Silent	p.T38T	1
TRIM71	BLCA	chr3	32932092	32932092	C	G	Missense_Mutation	p.Q466E	1
TRIM71	GBM	chr3	32915463	32915463	C	T	Nonsense_Mutation	p.R336*	1
TRIM71	HNSC	chr3	32933213	32933213	G	A	Silent		1
TRIM71	LIHC	chr3	32932471	32932471	C	G	Missense_Mutation		1
TRIM71	SKCM	chr3	32860396	32860396	T	C	Missense_Mutation	p.L275P	1
TRIM71	BLCA	chr3	32927521	32927521	G	A	Silent		1
TRIM71	HNSC	chr3	32932864	32932864	G	A	Missense_Mutation	p.R723Q	1
TRIM71	ESCA	chr3	32932232	32932232	C	T	Silent	p.H512	1
TRIM71	OV	chr3	32890468	32890468	G	-	Frame_Shift_Del		1
TRIM71	SKCM	chr3	32932697	32932697	C	T	Silent	p.I667I	1
TRIM71	STAD	chr3	32859727	32859727	C	T	Missense_Mutation	p.A52V	1
TRIM71	BLCA	chr3	32915444	32915444	G	A	Silent	p.L329L	1
TRIM71	HNSC	chr3	32931915	32931915	A	C	Missense_Mutation		1
TRIM71	SKCM	chr3	32932226	32932226	T	G	Nonsense_Mutation	p.Y510*	1
TRIM71	BLCA	chr3	32932410	32932410	G	C	Missense_Mutation		1
TRIM71	COAD	chr3	32927553	32927553	T	G	Missense_Mutation	p.L383R	1
TRIM71	LUAD	chr3	32933252	32933252	C	A	Missense_Mutation	p.D852E	1
TRIM71	LGG	chr3	32932914	32932914	G	A	Missense_Mutation	p.E740K	1
TRIM71	PAAD	chr3	32860298	32860298	G	A	Silent		1
TRIM71	READ	chr3	32932913	32932913	C	T	Silent	p.F739F	1
TRIM71	SKCM	chr3	32932970	32932970	G	A	Silent	p.E758E	1
TRIM71	STAD	chr3	32859669	32859669	T	C	Missense_Mutation	p.S33P	1
TRIM71	BLCA	chr3	32932639	32932639	C	T	Missense_Mutation	p.S648F	1
TRIM71	GBM	chr3	32933302	32933302	A	G	Silent	p.869	1
TRIM71	HNSC	chr3	32933083	32933083	G	A	Missense_Mutation		1
TRIM71	SKCM	chr3	32931965	32931965	G	A	Silent	p.E423E	1
TRIM71	BLCA	chr3	32933231	32933231	C	T	Silent		1
TRIM71	KIRP	chr3	32859580	32859580	C	T	Missense_Mutation	p.S3L	1
TRIM71	ESCA	chr3	32859629	32859629	C	T	Silent	p.C19	1
TRIM71	LGG	chr3	32915357	32915357	G	A	Silent	p.E300E	1
TRIM71	PAAD	chr3	32860161	32860161	C	T	Missense_Mutation	p.H197Y	1
TRIM71	SARC	chr3	32915368	32915368	G	T	Missense_Mutation		1
TRIM71	SKCM	chr3	32915464	32915464	G	A	Missense_Mutation	p.R336Q	1
TRIM71	STAD	chr3	32932817	32932817	G	A	Silent	p.A707A	1
TRIM71	BLCA	chr3	32932659	32932659	C	T	Nonsense_Mutation	p.R655*	1
TRIM71	GBM	chr3	32859711	32859711	G	A	Missense_Mutation	p.G47R	1
TRIM71	HNSC	chr3	32932010	32932010	G	T	Silent		1
TRIM71	SKCM	chr3	32860221	32860221	G	A	Missense_Mutation	p.E217K	1
TRIM71	STAD	chr3	32932420	32932421	-	A	Frame_Shift_Ins	p.P575fs	1
TRIM71	BLCA	chr3	32932217	32932217	C	A	Silent		1
TRIM71	COAD	chr3	32932074	32932074	A	G	Missense_Mutation	p.M460V	1
TRIM71	KIRP	chr3	32859581	32859581	G	T	Silent	p.S3S	1
TRIM71	BLCA	chr3	32932056	32932056	C	T	Nonsense_Mutation	p.Q454*	1
TRIM71	ESCA	chr3	32931919	32931919	T	C	Missense_Mutation		1
TRIM71	LGG	chr3	32932723	32932723	G	A	Missense_Mutation	p.R676H	1
TRIM71	SKCM	chr3	32932117	32932117	C	T	Missense_Mutation	p.S474F	1
TRIM71	STAD	chr3	32859730	32859730	C	G	Missense_Mutation	p.A53G	1
TRIM71	GBM	chr3	32915463	32915463	C	T	Nonsense_Mutation		1
TRIM71	HNSC	chr3	32931948	32931948	G	A	Missense_Mutation		1
TRIM71	SKCM	chr3	32932226	32932226	T	G	Nonsense_Mutation	p.Y510X	1
TRIM71	SKCM	chr3	32932869	32932869	C	T	Nonsense_Mutation	p.Q725*	1
TRIM71	BLCA	chr3	32860419	32860419	G	C	Missense_Mutation		1
TRIM71	COAD	chr3	32932353	32932353	C	T	Nonsense_Mutation	p.R553X	1
TRIM71	KIRP	chr3	32927537	32927537	C	A	Missense_Mutation	p.R378S	1
TRIM71	LUAD	chr3	32860366	32860366	T	A	Missense_Mutation	p.F265Y	1
TRIM71	BLCA	chr3	32932217	32932217	C	A	Silent	p.V507V	1
TRIM71	ESCA	chr3	32859540	32859540	C	G	Missense_Mutation		1
TRIM71	SKCM	chr3	32933053	32933053	C	T	Missense_Mutation	p.S786L	1
TRIM71	STAD	chr3	32859698	32859698	G	-	Frame_Shift_Del	p.S42fs	1
TRIM71	GBM	chr3	32933041	32933041	G	A	Missense_Mutation		1
TRIM71	HNSC	chr3	32932864	32932864	G	A	Missense_Mutation		1
TRIM71	LIHC	chr3	32932714	32932714	A	G	Missense_Mutation	p.D673G	1

Copy number variation (CNV) of TRIM71
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TRIM71
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96394	N/A	EI782752	DHRSX	chrY	2111611	+	TRIM71	chr3	32817021	+
96394	N/A	AY010234	DNAJC10	chr2	183601113	+	TRIM71	chr3	32936973	-
96394	N/A	BC030207	NR0B2	chr1	27237980	-	TRIM71	chr3	32933728	+
96394	N/A	BF247056	SYT16	chr14	62353645	-	TRIM71	chr3	32869047	-
94168	TGCT	TCGA-XY-A8S3-01B	TRIM71	chr3	32860424	+	CNOT10	chr3	32814949	+
94168	N/A	BM987958	TRIM71	chr3	32868226	+	RAB3B	chr1	52383396	+
96394	SARC	TCGA-MB-A8JK-01A	UBP1	chr3	33481228	-	TRIM71	chr3	32915310	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	TRIM71	0.000470488810476029	0.013
TGCT	TRIM71	0.0024346057331275	0.066
KIRC	TRIM71	0.00366848530288486	0.095
CHOL	TRIM71	0.0177016937438334	0.44
BRCA	TRIM71	0.0499765124896926	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	TRIM71	0.0446009374413919	1
LGG	TRIM71	0.0284562201938413	0.88
BRCA	TRIM71	0.0425586680294304	1
PRAD	TRIM71	0.00904271739292007	0.29
OV	TRIM71	0.00577374280014864	0.19

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source