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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PIWIL4 (NCBI Gene ID:143689)

Gene Summary

Gene Summary

Gene Information	Gene Name: PIWIL4
	Gene ID: 143689
	Gene Symbol	PIWIL4
	Gene ID	143689
	Gene Name	piwi like RNA-mediated gene silencing 4
	Synonyms	HIWI2\|MIWI2
	Cytomap	11q21
	Type of Gene	protein-coding
	Description	piwi-like protein 4piwi-like 4testis tissue sperm-binding protein Li 85P
	Modification date	20200313
	UniProtAcc	Q7Z3Z4

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PIWIL4	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'PIWIL4[title] AND translation [title] AND human.'

Gene	Title	PMID
PIWIL4	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000299001	94308164	94308296	In-frame
ENST00000299001	94337149	94337222	Frame-shift
ENST00000299001	94341748	94341852	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000299001	94308164	94308296	3216	378	509	852	55	99

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q7Z3Z4	55	99	1	852	Chain	ID=PRO_0000234572;Note=Piwi-like protein 4
Q7Z3Z4	55	99	1	69	Alternative sequence	ID=VSP_036665;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q7Z3Z4	55	99	78	78	Natural variant	ID=VAR_028367;Note=Q->R;Dbxref=dbSNP:rs12276921
Q7Z3Z4	55	99	99	99	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	PIWIL4	3.29305378581944	5.60797254840577e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
OV	PIWIL4	-0.046521126	0.001955708

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PIWIL4 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Epifactor	PIWIL4	VPS72	0.813707371	1.09E-11
CHOL	IUPHAR	PIWIL4	LPAR2	0.814444382	1.01E-11
DLBC	IUPHAR	PIWIL4	SLC9A9	0.818021303	1.27E-12
TGCT	TSG	PIWIL4	HECA	0.804872907	1.00E-36
UVM	Cell metabolism gene	PIWIL4	ME2	0.835871327	5.15E-22
UVM	IUPHAR	PIWIL4	IFNGR1	0.813287231	4.98E-20
UVM	TF	PIWIL4	ZNF75D	0.802937267	3.31E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	PIWIL4	TDRKH	-2.35054040805301	0.000154274946618889
LIHC	PIWIL4	HSP90AA1	-1.87137739671902	0.0003817245773207
STAD	PIWIL4	TDRKH	-1.54610939736591	0.000772962812334299
PRAD	PIWIL4	MAEL	-2.3661636167606	0.000817525595737914
LUAD	PIWIL4	MAEL	-6.19185333647027	0.0016989769898434
HNSC	PIWIL4	TDRD1	-2.22172147165928	0.00186235073124408
KIRP	PIWIL4	TDRD9	-1.44317546534812	0.00239070039242506
BLCA	PIWIL4	MOV10L1	-2.2459025740491	0.0033416748046875
KIRP	PIWIL4	FKBP6	-1.06618123891793	0.00378712571418864
LUAD	PIWIL4	FKBP6	-2.54133050249485	0.007411236655529
COAD	PIWIL4	MOV10L1	-1.2507305928268	0.00793844461441041
PRAD	PIWIL4	DICER1	1.54768558737379	0.0130781232419534
CHOL	PIWIL4	FKBP6	-3.42220640119472	0.0208625823327655
ESCA	PIWIL4	HSP90AA1	-2.95407832928575	0.0322265625
CHOL	PIWIL4	TDRKH	-3.94276179244914	0.0390625
BLCA	PIWIL4	TDRD9	1.06553720728077	0.040130615234375
KICH	PIWIL4	TDRKH	1.37293937269262	1.0073184967041e-05
BRCA	PIWIL4	HSP90AA1	2.1978220577015	1.13731762084626e-08
PRAD	PIWIL4	TDRD1	2.58804684959852	1.77484038698563e-08
KIRP	PIWIL4	MOV10L1	2.29966204672133	2.0815059542656e-07
KIRC	PIWIL4	TDRD9	-2.07747875035683	2.55316341696988e-08
BRCA	PIWIL4	MAEL	-1.18581225781999	2.88434406714333e-05
THCA	PIWIL4	TDRD9	-1.37443883161284	3.30629686127371e-10
STAD	PIWIL4	HSP90AA1	-1.65705125430285	3.51201742887497e-06
BRCA	PIWIL4	TNRC6A	-1.24656754002514	3.76762765813611e-06
KIRC	PIWIL4	TDRKH	1.35420573562768	3.87430708887757e-09
LUAD	PIWIL4	TDRD9	-2.98578541487185	4.65161857317772e-05
COAD	PIWIL4	TDRKH	-1.761968138371	6.03199005126954e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PIWIL4

DICER1, RELA, HIST1H1B, NEK4, PRSS1, CSTA, DCD, FABP5, KPRP, DDX39A, BEND3, TDRKH, FCHO1, PCDHGA9,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PIWIL4	chr11	94318680	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PIWIL4	chr11	94320265	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PIWIL4	chr11	94320300	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PIWIL4	chr11	94320305	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PIWIL4	chr11	94326720	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
PIWIL4	chr11	94330966	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PIWIL4	chr11	94335094	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PIWIL4	chr11	94340728	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PIWIL4	LUAD	chr11	94322291	94322291	A	G	Missense_Mutation	p.N307D	5
PIWIL4	CESC	chr11	94322352	94322352	A	T	Missense_Mutation		5
PIWIL4	CESC	chr11	94322353	94322353	G	A	Silent		5
PIWIL4	COAD	chr11	94352981	94352981	G	A	Missense_Mutation	p.E742K	4
PIWIL4	LUAD	chr11	94330994	94330994	A	G	Silent	p.L431L	4
PIWIL4	UCEC	chr11	94310653	94310653	G	T	Nonsense_Mutation	p.E170*	4
PIWIL4	SKCM	chr11	94341758	94341758	C	T	Silent	p.L617L	3
PIWIL4	UCS	chr11	94322371	94322371	G	T	Missense_Mutation	p.E333D	3
PIWIL4	BRCA	chr11	94308183	94308183	C	G	Missense_Mutation	p.S62C	3
PIWIL4	UCS	chr11	94318621	94318621	A	C	Missense_Mutation	p.K216Q	3
PIWIL4	LIHC	chr11	94353216	94353216	C	A	Missense_Mutation	p.T783N	3
PIWIL4	UCS	chr11	94310616	94310616	C	T	Silent	p.F157F	3
PIWIL4	UCEC	chr11	94301960	94301960	G	A	Missense_Mutation	p.R51K	3
PIWIL4	CESC	chr11	94337148	94337148	A	G	Splice_Site		3
PIWIL4	BLCA	chr11	94310554	94310554	A	G	Missense_Mutation	p.R137G	3
PIWIL4	UCEC	chr11	94351149	94351149	C	G	Missense_Mutation	p.H682D	3
PIWIL4	KIRP	chr11	94340737	94340737	A	G	Missense_Mutation	p.I591V	3
PIWIL4	PAAD	chr11	94310447	94310447	C	A	Missense_Mutation	p.S101Y	3
PIWIL4	KIRP	chr11	94341805	94341805	C	T	Silent	p.D632D	3
PIWIL4	LIHC	chr11	94353216	94353216	C	A	Missense_Mutation		3
PIWIL4	STAD	chr11	94340624	94340624	C	A	Missense_Mutation	p.S553Y	2
PIWIL4	UCEC	chr11	94335001	94335001	G	A	Missense_Mutation	p.R474Q	2
PIWIL4	BRCA	chr11	94331003	94331003	G	C	Missense_Mutation	p.W434C	2
PIWIL4	HNSC	chr11	94320237	94320237	T	C	Silent		2
PIWIL4	LIHC	chr11	94318670	94318670	C	A	Missense_Mutation		2
PIWIL4	STAD	chr11	94316686	94316686	C	T	Missense_Mutation	p.P196S	2
PIWIL4	CESC	chr11	94326762	94326762	G	A	Missense_Mutation	p.E369K	2
PIWIL4	BLCA	chr11	94335120	94335120	G	A	Missense_Mutation	p.G514R	2
PIWIL4	COAD	chr11	94337220	94337220	C	T	Silent	p.L546L	2
PIWIL4	SKCM	chr11	94310540	94310540	C	T	Missense_Mutation	p.P132L	2
PIWIL4	SKCM	chr11	94334973	94334973	T	A	Missense_Mutation	p.S465T	2
PIWIL4	UCEC	chr11	94340607	94340607	A	G	Silent	p.V547	2
PIWIL4	STAD	chr11	94308224	94308224	A	C	Missense_Mutation	p.N76H	2
PIWIL4	BLCA	chr11	94326765	94326765	G	C	Missense_Mutation		2
PIWIL4	BLCA	chr11	94340677	94340677	C	T	Missense_Mutation	p.P571S	2
PIWIL4	SKCM	chr11	94341757	94341757	C	T	Silent	p.S616S	2
PIWIL4	UCEC	chr11	94340634	94340634	G	T	Missense_Mutation	p.K556N	2
PIWIL4	STAD	chr11	94340675	94340675	G	A	Missense_Mutation	p.C570Y	2
PIWIL4	BLCA	chr11	94316613	94316613	G	A	Splice_Site		2
PIWIL4	BLCA	chr11	94328539	94328539	C	G	Silent	p.L405L	2
PIWIL4	KICH	chr11	94353042	94353042	G	A	Missense_Mutation	p.R762H	2
PIWIL4	LIHC	chr11	94318670	94318670	C	A	Missense_Mutation	p.P232Q	2
PIWIL4	SKCM	chr11	94320221	94320221	C	T	Missense_Mutation	p.S241F	2
PIWIL4	UCEC	chr11	94341805	94341805	C	T	Silent	p.D632	2
PIWIL4	CESC	chr11	94326762	94326762	G	A	Missense_Mutation		2
PIWIL4	HNSC	chr11	94341767	94341767	G	A	Missense_Mutation	p.V620I	2
PIWIL4	STAD	chr11	94328536	94328536	T	C	Silent	p.R404R	2
PIWIL4	KIRC	chr11	94308185	94308185	G	C	Missense_Mutation	p.G63R	2
PIWIL4	SKCM	chr11	94352941	94352941	G	A	Silent	p.V728V	2
PIWIL4	UCEC	chr11	94351164	94351164	C	T	Missense_Mutation	p.R687W	2
PIWIL4	HNSC	chr11	94349700	94349700	T	C	Missense_Mutation	p.V662A	2
PIWIL4	LAML	chr11	93940384	93940384	G	C	Missense_Mutation	p.A18P	2
PIWIL4	LIHC	chr11	94331044	94331044	T	C	Missense_Mutation		2
PIWIL4	STAD	chr11	94326774	94326774	G	A	Missense_Mutation	p.A373T	2
PIWIL4	LIHC	chr11	94354059	94354059	A	T	Silent	p.P820P	2
PIWIL4	SKCM	chr11	94318641	94318641	T	C	Silent	p.I222I	2
PIWIL4	UCEC	chr11	94352990	94352990	C	T	Missense_Mutation	p.R745C	2
PIWIL4	LGG	chr11	94328504	94328504	C	T	Nonsense_Mutation	p.Q394*	2
PIWIL4	LIHC	chr11	94351131	94351131	A	G	Missense_Mutation		2
PIWIL4	PAAD	chr11	94310447	94310447	C	A	Missense_Mutation		2
PIWIL4	STAD	chr11	94326792	94326792	C	T	Missense_Mutation	p.L379F	2
PIWIL4	SKCM	chr11	94316683	94316683	C	T	Silent	p.L195L	2
PIWIL4	UCEC	chr11	94308223	94308223	A	C	Missense_Mutation	p.K75N	2
PIWIL4	UCEC	chr11	94353018	94353018	C	A	Missense_Mutation	p.T754N	2
PIWIL4	LIHC	chr11	94337220	94337220	C	T	Silent		2
PIWIL4	LIHC	chr11	94352999	94352999	C	A	Missense_Mutation		2
PIWIL4	STAD	chr11	94353244	94353244	C	T	Silent	p.N792N	2
PIWIL4	SKCM	chr11	94353008	94353008	C	T	Missense_Mutation	p.P751S	2
PIWIL4	UCEC	chr11	94353164	94353164	T	C	Missense_Mutation	p.Y766H	2
PIWIL4	COAD	chr11	94322352	94322352	A	T	Missense_Mutation	p.Q327L	2
PIWIL4	LIHC	chr11	94354059	94354059	A	T	Silent		2
PIWIL4	SARC	chr11	94351157	94351157	G	T	Missense_Mutation		2
PIWIL4	STAD	chr11	94330984	94330984	G	A	Missense_Mutation	p.R428H	2
PIWIL4	LIHC	chr11	94353004	94353004	C	-	Frame_Shift_Del	p.N749fs	2
PIWIL4	SKCM	chr11	94340698	94340698	C	T	Missense_Mutation	p.L578F	2
PIWIL4	UCEC	chr11	94320235	94320235	T	C	Missense_Mutation	p.F246L	2
PIWIL4	COAD	chr11	94322353	94322353	G	A	Silent	p.Q327Q	2
PIWIL4	LIHC	chr11	94354053	94354053	T	G	Missense_Mutation		2
PIWIL4	SARC	chr11	94301961	94301961	G	T	Missense_Mutation		2
PIWIL4	STAD	chr11	94320238	94320238	G	A	Missense_Mutation	p.A247T	2
PIWIL4	SKCM	chr11	94300761	94300761	C	T	Missense_Mutation	p.A26V	2
PIWIL4	UCEC	chr11	94322298	94322298	G	T	Missense_Mutation	p.R309I	2
PIWIL4	STAD	chr11	94316686	94316686	C	T	Missense_Mutation		2
PIWIL4	BLCA	chr11	94316737	94316737	T	C	Splice_Site		2
PIWIL4	LIHC	chr11	94354053	94354053	T	G	Missense_Mutation	p.S818R	2
PIWIL4	STAD	chr11	94326704	94326704	G	A	Silent	p.S349S	2
PIWIL4	UCEC	chr11	94326748	94326748	G	T	Missense_Mutation	p.R364I	2
PIWIL4	BRCA	chr11	94322383	94322383	G	T	Silent	p.V337	2
PIWIL4	CESC	chr11	94316638	94316638	C	G	Missense_Mutation		2
PIWIL4	BLCA	chr11	94316728	94316728	T	C	Missense_Mutation	p.F210L	1
PIWIL4	COAD	chr11	94328518	94328518	T	G	Silent	p.A398A	1
PIWIL4	HNSC	chr11	94340739	94340739	C	T	Silent	p.I591I	1
PIWIL4	LIHC	chr11	94316706	94316706	C	A	Nonsense_Mutation	p.C202X	1
PIWIL4	SARC	chr11	94337172	94337172	G	T	Missense_Mutation	p.A530S	1
PIWIL4	KIRP	chr11	94301931	94301931	C	A	Silent		1
PIWIL4	LIHC	chr11	94340653	94340653	A	-	Frame_Shift_Del	p.K564fs	1
PIWIL4	LUAD	chr11	94316616	94316616	C	A	Silent	p.V172V	1
PIWIL4	BLCA	chr11	94340677	94340677	C	T	Missense_Mutation		1
PIWIL4	HNSC	chr11	94331061	94331061	A	C	Missense_Mutation	p.I454L	1
PIWIL4	LIHC	chr11	94308255	94308255	G	C	Missense_Mutation	p.C86S	1
PIWIL4	STAD	chr11	94335140	94335141	-	A	Frame_Shift_Ins	p.N521fs	1
PIWIL4	HNSC	chr11	94340739	94340739	C	T	Silent		1
PIWIL4	KIRP	chr11	94278671	94278671	C	A	Missense_Mutation		1
PIWIL4	LIHC	chr11	94316706	94316706	C	A	Nonsense_Mutation		1
PIWIL4	LIHC	chr11	94354095	94354095	G	T	Silent		1
PIWIL4	LUAD	chr11	94316682	94316682	G	A	Silent	p.E194E	1
PIWIL4	CESC	chr11	94341823	94341823	C	T	Silent	p.C638C	1
PIWIL4	COAD	chr11	94353309	94353309	C	T	Missense_Mutation	p.P814L	1
PIWIL4	KICH	chr11	94353042	94353042	G	A	Missense_Mutation		1
PIWIL4	SKCM	chr11	94322335	94322335	G	A	Silent	p.K321K	1
PIWIL4	THYM	chr11	94337149	94337149	G	A	Splice_Site	.	1
PIWIL4	BRCA	chr11	94318660	94318660	C	T	Missense_Mutation	p.P229S	1
PIWIL4	HNSC	chr11	94331061	94331061	A	C	Missense_Mutation		1
PIWIL4	KIRP	chr11	94340804	94340804	C	A	Missense_Mutation		1
PIWIL4	LUAD	chr11	94351135	94351135	G	T	Missense_Mutation	p.W677L	1
PIWIL4	LIHC	chr11	94318691	94318691	A	G	Missense_Mutation		1
PIWIL4	LUSC	chr11	94300723	94300723	C	T	Silent	p.A13A	1
PIWIL4	CESC	chr11	94337148	94337148	A	G	Splice_Site	e13-2	1
PIWIL4	THYM	chr11	94316713	94316713	G	T	Missense_Mutation	p.V205F	1
PIWIL4	SKCM	chr11	94353025	94353025	G	A	Silent	p.V756V	1
PIWIL4	KIRP	chr11	94340737	94340737	A	G	Missense_Mutation		1
PIWIL4	LUAD	chr11	94301943	94301943	C	T	Silent	p.G45G	1
PIWIL4	CESC	chr11	94316638	94316638	C	G	Missense_Mutation	p.Q180E	1
PIWIL4	LIHC	chr11	94351263	94351263	T	C	Missense_Mutation		1
PIWIL4	MESO	chr11	94349713	94349713	G	T	Missense_Mutation		1
PIWIL4	BLCA	chr11	94328539	94328539	C	G	Silent		1
PIWIL4	BLCA	chr11	94352998	94352998	A	T	Silent	p.V747V	1
PIWIL4	DLBC	chr11	94320300	94320300	C	T	Silent	p.V267V	1
PIWIL4	LIHC	chr11	94335097	94335097	T	C	Missense_Mutation	p.L506S	1
PIWIL4	SKCM	chr11	94318623	94318623	G	C	Missense_Mutation	p.K216N	1
PIWIL4	BLCA	chr11	94352998	94352998	A	T	Silent		1
PIWIL4	CESC	chr11	94341823	94341823	C	T	Silent	p.C638	1
PIWIL4	PAAD	chr11	94351179	94351179	C	A	Missense_Mutation		1
PIWIL4	READ	chr11	94354117	94354117	G	T	Nonsense_Mutation	p.E840X	1
PIWIL4	ESCA	chr11	94352930	94352930	A	T	Nonsense_Mutation	p.R725X	1
PIWIL4	KIRP	chr11	94300728	94300728	G	A	Missense_Mutation	p.S15N	1
PIWIL4	SKCM	chr11	94353174	94353174	A	G	Missense_Mutation	p.Y769C	1
PIWIL4	CESC	chr11	94322358	94322358	G	A	Missense_Mutation		1
PIWIL4	LUAD	chr11	94341824	94341824	G	T	Missense_Mutation	p.V639L	1
PIWIL4	BLCA	chr11	94310554	94310554	A	G	Missense_Mutation		1
PIWIL4	COAD	chr11	94320237	94320237	T	C	Silent	p.F246F	1
PIWIL4	READ	chr11	94331025	94331025	A	G	Missense_Mutation	p.I442V	1
PIWIL4	BLCA	chr11	94353178	94353178	G	A	Silent	p.L770L	1
PIWIL4	GBM	chr11	94328516	94328516	G	A	Missense_Mutation	p.A398T	1
PIWIL4	LIHC	chr11	94316706	94316706	C	A	Nonsense_Mutation	p.C202*	1
PIWIL4	SKCM	chr11	94326773	94326773	C	T	Silent	p.L372L	1
PIWIL4	CESC	chr11	94326710	94326710	G	A	Silent		1
PIWIL4	BLCA	chr11	94354146	94354146	C	G	Silent		1
PIWIL4	COAD	chr11	94320250	94320250	T	C	Missense_Mutation	p.S251P	1
PIWIL4	SARC	chr11	94337172	94337172	G	T	Missense_Mutation		1
PIWIL4	BLCA	chr11	94301962	94301962	A	G	Missense_Mutation	p.I52V	1
PIWIL4	GBM	chr11	94335056	94335056	C	T	Silent	p.S492S	1
PIWIL4	LIHC	chr11	94352999	94352999	C	A	Missense_Mutation	p.Q748K	1
PIWIL4	LIHC	chr11	94322348	94322348	T	C	Missense_Mutation		1
PIWIL4	LUAD	chr11	94320403	94320403	G	A	Missense_Mutation	p.V302I	1
PIWIL4	SKCM	chr11	94316730	94316730	C	T	Silent	p.F210F	1
PIWIL4	ACC	chr11	94340769	94340769	C	T	Silent	p.C601C	1
PIWIL4	CESC	chr11	94341823	94341823	C	T	Silent		1
PIWIL4	BLCA	chr11	94353178	94353178	G	A	Silent		1
PIWIL4	PAAD	chr11	94278557	94278557	G	T	Missense_Mutation		1
PIWIL4	BLCA	chr11	94331053	94331053	C	T	Missense_Mutation	p.S451L	1
PIWIL4	GBM	chr11	94335056	94335056	C	T	Silent		1
PIWIL4	KIRP	chr11	94300709	94300709	G	C	Missense_Mutation	p.A9P	1
PIWIL4	LIHC	chr11	94310600	94310600	A	G	Missense_Mutation		1
PIWIL4	LUAD	chr11	94310469	94310469	G	T	Silent	p.L108L	1
PIWIL4	STAD	chr11	94335140	94335141	-	-	Frame_Shift_Ins		1
PIWIL4	UCS	chr11	94310616	94310616	C	T	Silent		1
PIWIL4	BLCA	chr11	94316728	94316728	T	C	Missense_Mutation		1
PIWIL4	BLCA	chr11	94301962	94301962	A	G	Missense_Mutation		1
PIWIL4	BLCA	chr11	94316613	94316613	G	A	Splice_Site	p.V172_splice	1
PIWIL4	HNSC	chr11	94349700	94349700	T	C	Missense_Mutation		1
PIWIL4	KIRP	chr11	94278514	94278514	C	A	Silent		1
PIWIL4	LIHC	chr11	94301938	94301938	A	-	Frame_Shift_Del	p.N44fs	1
PIWIL4	LUAD	chr11	94308235	94308235	C	G	Missense_Mutation	p.D79E	1
PIWIL4	UCS	chr11	94318621	94318621	A	C	Missense_Mutation		1
PIWIL4	BLCA	chr11	94331053	94331053	C	T	Missense_Mutation		1
PIWIL4	COAD	chr11	94326765	94326765	G	C	Missense_Mutation	p.A370P	1
PIWIL4	SARC	chr11	94326770	94326770	G	T	Missense_Mutation		1
PIWIL4	SKCM	chr11	94340751	94340751	C	T	Silent	p.I595I	1
PIWIL4	HNSC	chr11	94341767	94341767	G	A	Missense_Mutation		1
PIWIL4	KIRP	chr11	94341805	94341805	C	T	Silent		1
PIWIL4	LIHC	chr11	94353014	94353014	G	-	Frame_Shift_Del	p.G753fs	1
PIWIL4	LIHC	chr11	94320331	94320331	A	G	Missense_Mutation		1
PIWIL4	LUAD	chr11	94330997	94330997	G	T	Missense_Mutation	p.E432D	1
PIWIL4	STAD	chr11	94335140	94335141	-	A	Frame_Shift_Ins	p.P520fs	1
PIWIL4	UCS	chr11	94322371	94322371	G	T	Missense_Mutation		1
PIWIL4	BLCA	chr11	94335120	94335120	G	A	Missense_Mutation		1

Copy number variation (CNV) of PIWIL4
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PIWIL4
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
83013	SARC	TCGA-KD-A5QS-01A	AMOTL1	chr11	94501726	+	PIWIL4	chr11	94340605	+
86450	SARC	TCGA-DX-A3LT-01A	PIWIL4	chr11	94301974	-	THRSP	chr11	77778705	+
86450	SARC	TCGA-DX-A3LT-01A	PIWIL4	chr11	94310658	+	THRSP	chr11	77778705	+
83013	SKCM	TCGA-D9-A4Z3-01A	SLC35F2	chr11	107729384	-	PIWIL4	chr11	94340605	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
GBM	PIWIL4	0.001207928745164	0.034
BRCA	PIWIL4	0.00255190037624743	0.069
KIRP	PIWIL4	0.00629838154428849	0.16
COAD	PIWIL4	0.0113366466888088	0.28
HNSC	PIWIL4	0.0148675090163444	0.36
KIRC	PIWIL4	0.0408431304316564	0.94

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	PIWIL4	4.23857974251119e-07	1.4e-05
LUSC	PIWIL4	0.00743558464405802	0.22
THCA	PIWIL4	0.00147151195273606	0.044
KIRC	PIWIL4	0.0309825161046911	0.84
BRCA	PIWIL4	2.43365575445902e-08	8e-07
PRAD	PIWIL4	0.00928137847023606	0.26
ESCA	PIWIL4	3.29902981173036e-06	1e-04

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0028960	Oligospermia	1	CTD_human