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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF1AX (NCBI Gene ID:1964)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF1AX
	Gene ID: 1964
	Gene Symbol	EIF1AX
	Gene ID	1964
	Gene Name	eukaryotic translation initiation factor 1A X-linked
	Synonyms	EIF1A\|EIF1AP1\|EIF4C\|eIF-1A\|eIF-4C
	Cytomap	Xp22.12
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 1A, X-chromosomalPutative eukaryotic translation initiation factor 1AeIF-1A X isoformeukaryotic translation initiation factor 1A, X chromosomeeukaryotic translation initiation factor 4C
	Modification date	20200313
	UniProtAcc	P47813

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF1AX	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF1AX[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF1AX	Molecular network including eIF1AX, RPS7, and 14-3-3γ regulates protein translation and cell proliferation in bovine mammary epithelial cells	25281768

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000379607	20152074	20152125	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000379607	20152074	20152125	4444	409	459	144	68	85

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P47813	68	85	1	144	Chain	ID=PRO_0000145101;Note=Eukaryotic translation initiation factor 1A%2C X-chromosomal
P47813	68	85	22	96	Domain	Note=S1-like
P47813	68	85	76	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1D7Q
P47813	68	85	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1D7Q

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	EIF1AX	1.69033449545845	9.99853946268559e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
ESCA	EIF1AX	hsa-miR-1-3p	99	0.323551913611303	0.00385787488580292

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
TGCT	EIF1AX	-0.127823521	0.008572796
PAAD	EIF1AX	-0.25375654	0.03013398

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF1AX (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Cell metabolism gene	EIF1AX	SMG1	0.801631326	4.17E-19
UVM	Cell metabolism gene	EIF1AX	SRP19	0.801734235	4.09E-19
UVM	Cell metabolism gene	EIF1AX	PSMD10	0.807077587	1.57E-19
UVM	Cell metabolism gene	EIF1AX	NUP50	0.807922131	1.35E-19
UVM	Cell metabolism gene	EIF1AX	SLC19A2	0.811946652	6.41E-20
UVM	Cell metabolism gene	EIF1AX	PPAT	0.81246117	5.82E-20
UVM	Cell metabolism gene	EIF1AX	DIS3	0.812846855	5.41E-20
UVM	Cell metabolism gene	EIF1AX	FBXW7	0.813824979	4.50E-20
UVM	Cell metabolism gene	EIF1AX	C1GALT1	0.814921816	3.66E-20
UVM	Cell metabolism gene	EIF1AX	FPGT	0.815384554	3.35E-20
UVM	Cell metabolism gene	EIF1AX	ACADSB	0.817861755	2.08E-20
UVM	Cell metabolism gene	EIF1AX	DBT	0.819363931	1.55E-20
UVM	Cell metabolism gene	EIF1AX	PIKFYVE	0.820088495	1.35E-20
UVM	Cell metabolism gene	EIF1AX	GPAM	0.821077317	1.11E-20
UVM	Cell metabolism gene	EIF1AX	TRDMT1	0.821792016	9.61E-21
UVM	Cell metabolism gene	EIF1AX	CCT2	0.822500603	8.35E-21
UVM	Cell metabolism gene	EIF1AX	NUP107	0.823473754	6.87E-21
UVM	Cell metabolism gene	EIF1AX	TBL1XR1	0.823891568	6.32E-21
UVM	Cell metabolism gene	EIF1AX	VBP1	0.824301075	5.82E-21
UVM	Cell metabolism gene	EIF1AX	LPGAT1	0.825584183	4.48E-21
UVM	Cell metabolism gene	EIF1AX	TRMT11	0.828133584	2.66E-21
UVM	Cell metabolism gene	EIF1AX	ALG13	0.831106518	1.43E-21
UVM	Cell metabolism gene	EIF1AX	CSGALNACT2	0.831718834	1.26E-21
UVM	Cell metabolism gene	EIF1AX	XPO1	0.833305663	8.96E-22
UVM	Cell metabolism gene	EIF1AX	PRKAA1	0.833532629	8.54E-22
UVM	Cell metabolism gene	EIF1AX	EDEM3	0.835245453	5.90E-22
UVM	Cell metabolism gene	EIF1AX	NUDT12	0.8354993	5.59E-22
UVM	Cell metabolism gene	EIF1AX	MTR	0.837520075	3.59E-22
UVM	Cell metabolism gene	EIF1AX	PLA2G12A	0.838190057	3.10E-22
UVM	Cell metabolism gene	EIF1AX	AGPS	0.842542757	1.17E-22
UVM	Cell metabolism gene	EIF1AX	ACSL4	0.843891863	8.58E-23
UVM	Cell metabolism gene	EIF1AX	NUP54	0.845620728	5.75E-23
UVM	Cell metabolism gene	EIF1AX	MTMR6	0.846353837	4.85E-23
UVM	Cell metabolism gene	EIF1AX	MED17	0.846594513	4.58E-23
UVM	Cell metabolism gene	EIF1AX	RANBP2	0.847868463	3.39E-23
UVM	Cell metabolism gene	EIF1AX	ENOPH1	0.848576957	2.87E-23
UVM	Cell metabolism gene	EIF1AX	NFYB	0.848738498	2.76E-23
UVM	Cell metabolism gene	EIF1AX	DCK	0.849662425	2.22E-23
UVM	Cell metabolism gene	EIF1AX	AASDHPPT	0.849917773	2.08E-23
UVM	Cell metabolism gene	EIF1AX	SACM1L	0.852193748	1.20E-23
UVM	Cell metabolism gene	EIF1AX	PSMC6	0.852401348	1.14E-23
UVM	Cell metabolism gene	EIF1AX	GRPEL2	0.85544396	5.39E-24
UVM	Cell metabolism gene	EIF1AX	PIGA	0.855832115	4.89E-24
UVM	Cell metabolism gene	EIF1AX	NAMPT	0.859426122	1.96E-24
UVM	Cell metabolism gene	EIF1AX	MANEA	0.861185389	1.24E-24
UVM	Cell metabolism gene	EIF1AX	NUPL2	0.86245404	8.91E-25
UVM	Cell metabolism gene	EIF1AX	GXYLT1	0.862836393	8.05E-25
UVM	Cell metabolism gene	EIF1AX	ALG10B	0.864130993	5.71E-25
UVM	Cell metabolism gene	EIF1AX	IDI1	0.868515304	1.73E-25
UVM	Cell metabolism gene	EIF1AX	PNPLA8	0.870388433	1.03E-25
UVM	Cell metabolism gene	EIF1AX	PPP1CB	0.874177671	3.48E-26
UVM	Cell metabolism gene	EIF1AX	FAR1	0.875222294	2.57E-26
UVM	Cell metabolism gene	EIF1AX	FBXL3	0.875449599	2.40E-26
UVM	Cell metabolism gene	EIF1AX	ETNK1	0.878173452	1.07E-26
UVM	Cell metabolism gene	EIF1AX	GNPDA2	0.890675847	2.00E-28
UVM	CGC	EIF1AX	PALB2	0.800319251	5.25E-19
UVM	CGC	EIF1AX	USP8	0.80167712	4.13E-19
UVM	CGC	EIF1AX	N4BP2	0.803074761	3.23E-19
UVM	CGC	EIF1AX	JAK2	0.803379945	3.06E-19
UVM	CGC	EIF1AX	APC	0.803591353	2.95E-19
UVM	CGC	EIF1AX	HSP90AA1	0.804296335	2.60E-19
UVM	CGC	EIF1AX	PWWP2A	0.805737251	2.01E-19
UVM	CGC	EIF1AX	ABI1	0.806366131	1.79E-19
UVM	CGC	EIF1AX	ARID2	0.806409558	1.78E-19
UVM	CGC	EIF1AX	BAZ1A	0.806690276	1.69E-19
UVM	CGC	EIF1AX	ITGAV	0.806839524	1.64E-19
UVM	CGC	EIF1AX	POT1	0.806901833	1.62E-19
UVM	CGC	EIF1AX	ATM	0.807168452	1.55E-19
UVM	CGC	EIF1AX	ARHGAP5	0.807263022	1.52E-19
UVM	CGC	EIF1AX	ATF1	0.808673179	1.18E-19
UVM	CGC	EIF1AX	RAD17	0.80907908	1.09E-19
UVM	CGC	EIF1AX	TRIM33	0.811527866	6.93E-20
UVM	CGC	EIF1AX	FBXW7	0.813824979	4.50E-20
UVM	CGC	EIF1AX	AKAP9	0.814295267	4.12E-20
UVM	CGC	EIF1AX	KDM6A	0.815737973	3.13E-20
UVM	CGC	EIF1AX	TET2	0.817464969	2.24E-20
UVM	CGC	EIF1AX	ERCC4	0.823122022	7.37E-21
UVM	CGC	EIF1AX	TBL1XR1	0.823891568	6.32E-21
UVM	CGC	EIF1AX	MSH2	0.824486093	5.60E-21
UVM	CGC	EIF1AX	GOPC	0.826357114	3.83E-21
UVM	CGC	EIF1AX	CUL3	0.827276725	3.17E-21
UVM	CGC	EIF1AX	DDX10	0.828825237	2.30E-21
UVM	CGC	EIF1AX	KTN1	0.829471015	2.01E-21
UVM	CGC	EIF1AX	FBXO11	0.831007439	1.46E-21
UVM	CGC	EIF1AX	XPO1	0.833305663	8.96E-22
UVM	CGC	EIF1AX	DICER1	0.834103879	7.55E-22
UVM	CGC	EIF1AX	BMPR1A	0.83562027	5.44E-22
UVM	CGC	EIF1AX	SMAD4	0.839509219	2.31E-22
UVM	CGC	EIF1AX	KRAS	0.841098321	1.62E-22
UVM	CGC	EIF1AX	BCLAF1	0.846001306	5.26E-23
UVM	CGC	EIF1AX	RANBP2	0.847868463	3.39E-23
UVM	CGC	EIF1AX	MALT1	0.850519194	1.80E-23
UVM	CGC	EIF1AX	RGPD3	0.853552639	8.61E-24
UVM	CGC	EIF1AX	MLLT10	0.856613939	4.01E-24
UVM	CGC	EIF1AX	CDC73	0.857773541	2.99E-24
UVM	CGC	EIF1AX	ATRX	0.858373436	2.57E-24
UVM	CGC	EIF1AX	PHF6	0.865946951	3.50E-25
UVM	CGC	EIF1AX	DEK	0.866241251	3.23E-25
UVM	CGC	EIF1AX	SF3B1	0.871225921	8.11E-26
UVM	CGC	EIF1AX	SUZ12	0.873703971	3.99E-26
UVM	CGC	EIF1AX	ETNK1	0.878173452	1.07E-26
UVM	CGC	EIF1AX	CREB1	0.880429441	5.39E-27
UVM	CGC	EIF1AX	KIF5B	0.880914054	4.64E-27
UVM	CGC	EIF1AX	PMS1	0.89488697	4.70E-29
UVM	CGC	EIF1AX	STAG2	0.902147967	3.32E-30
UVM	Epifactor	EIF1AX	SUV39H2	0.802306462	3.70E-19
UVM	Epifactor	EIF1AX	JAK2	0.803379945	3.06E-19
UVM	Epifactor	EIF1AX	HAT1	0.806067983	1.89E-19
UVM	Epifactor	EIF1AX	HLTF	0.806284838	1.82E-19
UVM	Epifactor	EIF1AX	ARID2	0.806409558	1.78E-19
UVM	Epifactor	EIF1AX	BAZ1A	0.806690276	1.69E-19
UVM	Epifactor	EIF1AX	ATM	0.807168452	1.55E-19
UVM	Epifactor	EIF1AX	BRWD3	0.80907869	1.09E-19
UVM	Epifactor	EIF1AX	CHUK	0.810223064	8.83E-20
UVM	Epifactor	EIF1AX	TRIM33	0.811527866	6.93E-20
UVM	Epifactor	EIF1AX	CDK17	0.811610903	6.82E-20
UVM	Epifactor	EIF1AX	ACTR6	0.812579852	5.69E-20
UVM	Epifactor	EIF1AX	UBE2D1	0.814887148	3.68E-20
UVM	Epifactor	EIF1AX	KDM6A	0.815737973	3.13E-20
UVM	Epifactor	EIF1AX	FAM175A	0.816594426	2.65E-20
UVM	Epifactor	EIF1AX	CBX3	0.816631353	2.64E-20
UVM	Epifactor	EIF1AX	TET2	0.817464969	2.24E-20
UVM	Epifactor	EIF1AX	PHF20L1	0.817810007	2.10E-20
UVM	Epifactor	EIF1AX	YY1	0.818081876	1.99E-20
UVM	Epifactor	EIF1AX	UCHL5	0.819868227	1.41E-20
UVM	Epifactor	EIF1AX	TAF7	0.821530693	1.01E-20
UVM	Epifactor	EIF1AX	BRMS1L	0.822347963	8.60E-21
UVM	Epifactor	EIF1AX	TBL1XR1	0.823891568	6.32E-21
UVM	Epifactor	EIF1AX	HCFC2	0.825810022	4.28E-21
UVM	Epifactor	EIF1AX	CUL3	0.827276725	3.17E-21
UVM	Epifactor	EIF1AX	TADA1	0.829178506	2.14E-21
UVM	Epifactor	EIF1AX	SMARCAD1	0.829305617	2.08E-21
UVM	Epifactor	EIF1AX	ZBTB33	0.829573211	1.97E-21
UVM	Epifactor	EIF1AX	CIR1	0.831406266	1.34E-21
UVM	Epifactor	EIF1AX	DNAJC2	0.831971724	1.19E-21
UVM	Epifactor	EIF1AX	MBTD1	0.832258083	1.12E-21
UVM	Epifactor	EIF1AX	DDX50	0.833324274	8.93E-22
UVM	Epifactor	EIF1AX	USP15	0.833428196	8.73E-22
UVM	Epifactor	EIF1AX	PRKAA1	0.833532629	8.54E-22
UVM	Epifactor	EIF1AX	AEBP2	0.836563026	4.43E-22
UVM	Epifactor	EIF1AX	TLK1	0.837379901	3.71E-22
UVM	Epifactor	EIF1AX	BRWD1	0.83904654	2.56E-22
UVM	Epifactor	EIF1AX	EPC2	0.840437201	1.88E-22
UVM	Epifactor	EIF1AX	HMGB1	0.840623398	1.80E-22
UVM	Epifactor	EIF1AX	NSL1	0.841048885	1.64E-22
UVM	Epifactor	EIF1AX	TAF9B	0.842045207	1.31E-22
UVM	Epifactor	EIF1AX	UHRF2	0.844471364	7.51E-23
UVM	Epifactor	EIF1AX	CHD9	0.844694589	7.13E-23
UVM	Epifactor	EIF1AX	MASTL	0.846649069	4.52E-23
UVM	Epifactor	EIF1AX	CTBP2	0.84709587	4.07E-23
UVM	Epifactor	EIF1AX	SMEK1	0.848501136	2.92E-23
UVM	Epifactor	EIF1AX	NFYB	0.848738498	2.76E-23
UVM	Epifactor	EIF1AX	OGT	0.848784258	2.73E-23
UVM	Epifactor	EIF1AX	ZMYND11	0.84978683	2.15E-23
UVM	Epifactor	EIF1AX	PHIP	0.851165179	1.54E-23
UVM	Epifactor	EIF1AX	BRCC3	0.852573152	1.10E-23
UVM	Epifactor	EIF1AX	ATAD2B	0.85367687	8.35E-24
UVM	Epifactor	EIF1AX	BAZ2B	0.853773989	8.15E-24
UVM	Epifactor	EIF1AX	MLLT10	0.856613939	4.01E-24
UVM	Epifactor	EIF1AX	RCOR3	0.856629162	4.00E-24
UVM	Epifactor	EIF1AX	NIPBL	0.856745961	3.88E-24
UVM	Epifactor	EIF1AX	CDC73	0.857773541	2.99E-24
UVM	Epifactor	EIF1AX	ATRX	0.858373436	2.57E-24
UVM	Epifactor	EIF1AX	CUL4B	0.859200523	2.08E-24
UVM	Epifactor	EIF1AX	SIRT1	0.859764558	1.80E-24
UVM	Epifactor	EIF1AX	PCGF6	0.862638231	8.48E-25
UVM	Epifactor	EIF1AX	DNTTIP2	0.864776995	4.80E-25
UVM	Epifactor	EIF1AX	INO80D	0.865214045	4.27E-25
UVM	Epifactor	EIF1AX	DEK	0.866241251	3.23E-25
UVM	Epifactor	EIF1AX	FAM175B	0.867934888	2.03E-25
UVM	Epifactor	EIF1AX	SF3B1	0.871225921	8.11E-26
UVM	Epifactor	EIF1AX	JMJD1C	0.873285776	4.50E-26
UVM	Epifactor	EIF1AX	SUZ12	0.873703971	3.99E-26
UVM	Epifactor	EIF1AX	ARID4A	0.875030667	2.71E-26
UVM	Epifactor	EIF1AX	CUL5	0.876536796	1.74E-26
UVM	Epifactor	EIF1AX	ARID4B	0.877971007	1.14E-26
UVM	Epifactor	EIF1AX	CHD1	0.878618057	9.35E-27
UVM	Epifactor	EIF1AX	SMEK2	0.88309089	2.36E-27
UVM	Epifactor	EIF1AX	CUL2	0.903772926	1.78E-30
UVM	Epifactor	EIF1AX	RMI1	0.9078235	3.60E-31
UVM	Epifactor	EIF1AX	RLIM	0.910912248	1.01E-31
UVM	Epifactor	EIF1AX	YEATS4	0.925473152	1.27E-34
UVM	IUPHAR	EIF1AX	SMG1	0.801631326	4.17E-19
UVM	IUPHAR	EIF1AX	SUV39H2	0.802306462	3.70E-19
UVM	IUPHAR	EIF1AX	CRBN	0.802652978	3.48E-19
UVM	IUPHAR	EIF1AX	STK17A	0.802853835	3.36E-19
UVM	IUPHAR	EIF1AX	JAK2	0.803379945	3.06E-19
UVM	IUPHAR	EIF1AX	CYP2R1	0.803551196	2.97E-19
UVM	IUPHAR	EIF1AX	HSP90AA1	0.804296335	2.60E-19
UVM	IUPHAR	EIF1AX	TAS2R14	0.804783198	2.38E-19
UVM	IUPHAR	EIF1AX	HAT1	0.806067983	1.89E-19
UVM	IUPHAR	EIF1AX	BAZ1A	0.806690276	1.69E-19
UVM	IUPHAR	EIF1AX	ITGAV	0.806839524	1.64E-19
UVM	IUPHAR	EIF1AX	ATM	0.807168452	1.55E-19
UVM	IUPHAR	EIF1AX	RPS6KC1	0.808343972	1.25E-19
UVM	IUPHAR	EIF1AX	BRWD3	0.80907869	1.09E-19
UVM	IUPHAR	EIF1AX	CHUK	0.810223064	8.83E-20
UVM	IUPHAR	EIF1AX	ABCB10	0.810727234	8.05E-20
UVM	IUPHAR	EIF1AX	MAPK6	0.810937505	7.74E-20
UVM	IUPHAR	EIF1AX	TRIM33	0.811527866	6.93E-20
UVM	IUPHAR	EIF1AX	CDK17	0.811610903	6.82E-20
UVM	IUPHAR	EIF1AX	SLC19A2	0.811946652	6.41E-20
UVM	IUPHAR	EIF1AX	MFN1	0.812175958	6.14E-20
UVM	IUPHAR	EIF1AX	PPAT	0.81246117	5.82E-20
UVM	IUPHAR	EIF1AX	TNKS2	0.813042788	5.22E-20
UVM	IUPHAR	EIF1AX	IRAK4	0.814069408	4.30E-20
UVM	IUPHAR	EIF1AX	KDM6A	0.815737973	3.13E-20
UVM	IUPHAR	EIF1AX	PKN2	0.816286436	2.82E-20
UVM	IUPHAR	EIF1AX	NAPEPLD	0.817960574	2.04E-20
UVM	IUPHAR	EIF1AX	PIKFYVE	0.820088495	1.35E-20
UVM	IUPHAR	EIF1AX	SLC30A5	0.820167351	1.32E-20
UVM	IUPHAR	EIF1AX	MAP3K2	0.820334979	1.28E-20
UVM	IUPHAR	EIF1AX	BMPR2	0.823043971	7.49E-21
UVM	IUPHAR	EIF1AX	SENP7	0.826272155	3.90E-21
UVM	IUPHAR	EIF1AX	SLC30A9	0.827063444	3.31E-21
UVM	IUPHAR	EIF1AX	USP14	0.82775198	2.88E-21
UVM	IUPHAR	EIF1AX	FBXO11	0.831007439	1.46E-21
UVM	IUPHAR	EIF1AX	XPO1	0.833305663	8.96E-22
UVM	IUPHAR	EIF1AX	PRKAA1	0.833532629	8.54E-22
UVM	IUPHAR	EIF1AX	SENP6	0.833807795	8.05E-22
UVM	IUPHAR	EIF1AX	BMPR1A	0.83562027	5.44E-22
UVM	IUPHAR	EIF1AX	TBK1	0.835787123	5.25E-22
UVM	IUPHAR	EIF1AX	NR2C1	0.83737521	3.71E-22
UVM	IUPHAR	EIF1AX	TLK1	0.837379901	3.71E-22
UVM	IUPHAR	EIF1AX	MTR	0.837520075	3.59E-22
UVM	IUPHAR	EIF1AX	PRPF4B	0.838083147	3.17E-22
UVM	IUPHAR	EIF1AX	PLA2G12A	0.838190057	3.10E-22
UVM	IUPHAR	EIF1AX	BRWD1	0.83904654	2.56E-22
UVM	IUPHAR	EIF1AX	CLK4	0.839628971	2.25E-22
UVM	IUPHAR	EIF1AX	KRAS	0.841098321	1.62E-22
UVM	IUPHAR	EIF1AX	MAP4K3	0.845563962	5.83E-23
UVM	IUPHAR	EIF1AX	MASTL	0.846649069	4.52E-23
UVM	IUPHAR	EIF1AX	NR3C1	0.848755084	2.75E-23
UVM	IUPHAR	EIF1AX	SLC25A46	0.848770439	2.74E-23
UVM	IUPHAR	EIF1AX	TRPM7	0.849205012	2.47E-23
UVM	IUPHAR	EIF1AX	ZMYND11	0.84978683	2.15E-23
UVM	IUPHAR	EIF1AX	MALT1	0.850519194	1.80E-23
UVM	IUPHAR	EIF1AX	PHIP	0.851165179	1.54E-23
UVM	IUPHAR	EIF1AX	VRK2	0.853084762	9.66E-24
UVM	IUPHAR	EIF1AX	ATAD2B	0.85367687	8.35E-24
UVM	IUPHAR	EIF1AX	BAZ2B	0.853773989	8.15E-24
UVM	IUPHAR	EIF1AX	CLK1	0.854180129	7.37E-24
UVM	IUPHAR	EIF1AX	STK38L	0.857905176	2.89E-24
UVM	IUPHAR	EIF1AX	SIRT1	0.859764558	1.80E-24
UVM	IUPHAR	EIF1AX	XIAP	0.862706444	8.33E-25
UVM	IUPHAR	EIF1AX	NEK7	0.86425105	5.53E-25
UVM	IUPHAR	EIF1AX	YES1	0.8642815	5.48E-25
UVM	IUPHAR	EIF1AX	NEK1	0.865957918	3.49E-25
UVM	IUPHAR	EIF1AX	RIOK3	0.867973166	2.01E-25
UVM	IUPHAR	EIF1AX	IDI1	0.868515304	1.73E-25
UVM	IUPHAR	EIF1AX	JMJD1C	0.873285776	4.50E-26
UVM	IUPHAR	EIF1AX	CSNK1G3	0.87410613	3.55E-26
UVM	IUPHAR	EIF1AX	SLK	0.874370052	3.29E-26
UVM	IUPHAR	EIF1AX	BIRC2	0.888809918	3.73E-28
UVM	Kinase	EIF1AX	SMG1	0.801631326	4.17E-19
UVM	Kinase	EIF1AX	STK17A	0.802853835	3.36E-19
UVM	Kinase	EIF1AX	JAK2	0.803379945	3.06E-19
UVM	Kinase	EIF1AX	BAZ1A	0.806690276	1.69E-19
UVM	Kinase	EIF1AX	ATM	0.807168452	1.55E-19
UVM	Kinase	EIF1AX	RPS6KC1	0.808343972	1.25E-19
UVM	Kinase	EIF1AX	CHUK	0.810223064	8.83E-20
UVM	Kinase	EIF1AX	MAPK6	0.810937505	7.74E-20
UVM	Kinase	EIF1AX	TRIM33	0.811527866	6.93E-20
UVM	Kinase	EIF1AX	PAN3	0.811534877	6.92E-20
UVM	Kinase	EIF1AX	CDK17	0.811610903	6.82E-20
UVM	Kinase	EIF1AX	IRAK4	0.814069408	4.30E-20
UVM	Kinase	EIF1AX	PKN2	0.816286436	2.82E-20
UVM	Kinase	EIF1AX	MAP3K2	0.820334979	1.28E-20
UVM	Kinase	EIF1AX	BMPR2	0.823043971	7.49E-21
UVM	Kinase	EIF1AX	PRKAA1	0.833532629	8.54E-22
UVM	Kinase	EIF1AX	BMPR1A	0.83562027	5.44E-22
UVM	Kinase	EIF1AX	TBK1	0.835787123	5.25E-22
UVM	Kinase	EIF1AX	TLK1	0.837379901	3.71E-22
UVM	Kinase	EIF1AX	PRPF4B	0.838083147	3.17E-22
UVM	Kinase	EIF1AX	CLK4	0.839628971	2.25E-22
UVM	Kinase	EIF1AX	MAP4K3	0.845563962	5.83E-23
UVM	Kinase	EIF1AX	MASTL	0.846649069	4.52E-23
UVM	Kinase	EIF1AX	TRPM7	0.849205012	2.47E-23
UVM	Kinase	EIF1AX	VRK2	0.853084762	9.66E-24
UVM	Kinase	EIF1AX	CLK1	0.854180129	7.37E-24
UVM	Kinase	EIF1AX	STK38L	0.857905176	2.89E-24
UVM	Kinase	EIF1AX	NEK7	0.86425105	5.53E-25
UVM	Kinase	EIF1AX	YES1	0.8642815	5.48E-25
UVM	Kinase	EIF1AX	NEK1	0.865957918	3.49E-25
UVM	Kinase	EIF1AX	RIOK3	0.867973166	2.01E-25
UVM	Kinase	EIF1AX	CSNK1G3	0.87410613	3.55E-26
UVM	Kinase	EIF1AX	SLK	0.874370052	3.29E-26
UVM	TF	EIF1AX	ZNF223	0.800092823	5.46E-19
UVM	TF	EIF1AX	ZNF443	0.800710312	4.90E-19
UVM	TF	EIF1AX	LCOR	0.80140785	4.34E-19
UVM	TF	EIF1AX	ZNF627	0.802273847	3.72E-19
UVM	TF	EIF1AX	ZNF568	0.80392668	2.77E-19
UVM	TF	EIF1AX	ZNF347	0.804134308	2.67E-19
UVM	TF	EIF1AX	ZNF200	0.804455529	2.52E-19
UVM	TF	EIF1AX	ZNF326	0.80498703	2.29E-19
UVM	TF	EIF1AX	ARID2	0.806409558	1.78E-19
UVM	TF	EIF1AX	ATF1	0.808673179	1.18E-19
UVM	TF	EIF1AX	PRDM10	0.809279833	1.05E-19
UVM	TF	EIF1AX	THAP2	0.809317282	1.04E-19
UVM	TF	EIF1AX	ZNF615	0.81009128	9.05E-20
UVM	TF	EIF1AX	ZNF558	0.810138786	8.97E-20
UVM	TF	EIF1AX	ZNF654	0.810505055	8.38E-20
UVM	TF	EIF1AX	ZNF146	0.8105805	8.27E-20
UVM	TF	EIF1AX	ZNF222	0.812453218	5.83E-20
UVM	TF	EIF1AX	ZNF480	0.812959374	5.30E-20
UVM	TF	EIF1AX	BACH1	0.814671052	3.83E-20
UVM	TF	EIF1AX	TTF1	0.816202537	2.86E-20
UVM	TF	EIF1AX	ZNF611	0.816219201	2.85E-20
UVM	TF	EIF1AX	ZNF600	0.81666193	2.62E-20
UVM	TF	EIF1AX	ZNF235	0.816689598	2.61E-20
UVM	TF	EIF1AX	TET2	0.817464969	2.24E-20
UVM	TF	EIF1AX	YY1	0.818081876	1.99E-20
UVM	TF	EIF1AX	ZNF224	0.819924716	1.39E-20
UVM	TF	EIF1AX	ZNF440	0.820775632	1.18E-20
UVM	TF	EIF1AX	ZMAT1	0.820921425	1.14E-20
UVM	TF	EIF1AX	ZNF624	0.82104105	1.12E-20
UVM	TF	EIF1AX	ZNF585A	0.821817572	9.56E-21
UVM	TF	EIF1AX	ZFP30	0.822433003	8.46E-21
UVM	TF	EIF1AX	ZNF23	0.823657424	6.62E-21
UVM	TF	EIF1AX	ZNF100	0.823801833	6.43E-21
UVM	TF	EIF1AX	ZNF227	0.824905527	5.15E-21
UVM	TF	EIF1AX	ZNF799	0.825606701	4.46E-21
UVM	TF	EIF1AX	ZNF354A	0.825891838	4.21E-21
UVM	TF	EIF1AX	ZNF397	0.826491749	3.73E-21
UVM	TF	EIF1AX	ZNF160	0.826791991	3.50E-21
UVM	TF	EIF1AX	ZNF614	0.828798855	2.32E-21
UVM	TF	EIF1AX	ZNF92	0.829036868	2.20E-21
UVM	TF	EIF1AX	ZBTB33	0.829573211	1.97E-21
UVM	TF	EIF1AX	ZNF44	0.829709407	1.92E-21
UVM	TF	EIF1AX	ZNF383	0.830591867	1.59E-21
UVM	TF	EIF1AX	ZNF484	0.830662279	1.57E-21
UVM	TF	EIF1AX	ZNF468	0.835033189	6.18E-22
UVM	TF	EIF1AX	ZNF507	0.835153389	6.02E-22
UVM	TF	EIF1AX	ZNF430	0.835559093	5.52E-22
UVM	TF	EIF1AX	ZNF420	0.83585743	5.17E-22
UVM	TF	EIF1AX	AEBP2	0.836563026	4.43E-22
UVM	TF	EIF1AX	ZNF138	0.836610146	4.39E-22
UVM	TF	EIF1AX	ZFP14	0.836837422	4.17E-22
UVM	TF	EIF1AX	ZBTB6	0.836935725	4.08E-22
UVM	TF	EIF1AX	NR2C1	0.83737521	3.71E-22
UVM	TF	EIF1AX	ZNF91	0.837440839	3.66E-22
UVM	TF	EIF1AX	ZNF765	0.838029539	3.21E-22
UVM	TF	EIF1AX	ZNF143	0.838421066	2.95E-22
UVM	TF	EIF1AX	ZNF320	0.838929656	2.63E-22
UVM	TF	EIF1AX	ZNF644	0.839148761	2.51E-22
UVM	TF	EIF1AX	SMAD4	0.839509219	2.31E-22
UVM	TF	EIF1AX	ZNF782	0.839598124	2.27E-22
UVM	TF	EIF1AX	ZNF41	0.839714283	2.21E-22
UVM	TF	EIF1AX	ZNF546	0.840128446	2.01E-22
UVM	TF	EIF1AX	FOXN2	0.840506556	1.85E-22
UVM	TF	EIF1AX	PURB	0.842087915	1.29E-22
UVM	TF	EIF1AX	ZNF700	0.842437524	1.20E-22
UVM	TF	EIF1AX	ZNF808	0.842452806	1.19E-22
UVM	TF	EIF1AX	MEF2A	0.843783382	8.79E-23
UVM	TF	EIF1AX	ZNF253	0.844529637	7.41E-23
UVM	TF	EIF1AX	ZNF658	0.845487218	5.93E-23
UVM	TF	EIF1AX	ZNF674	0.847278342	3.90E-23
UVM	TF	EIF1AX	ZBED5	0.847697425	3.53E-23
UVM	TF	EIF1AX	TOPORS	0.847853353	3.41E-23
UVM	TF	EIF1AX	ZNF529	0.847895995	3.37E-23
UVM	TF	EIF1AX	NFYB	0.848738498	2.76E-23
UVM	TF	EIF1AX	NR3C1	0.848755084	2.75E-23
UVM	TF	EIF1AX	JRKL	0.84917322	2.49E-23
UVM	TF	EIF1AX	ZNF292	0.849750379	2.17E-23
UVM	TF	EIF1AX	EEA1	0.850443651	1.84E-23
UVM	TF	EIF1AX	ZNF675	0.850451464	1.83E-23
UVM	TF	EIF1AX	ZNF234	0.851429525	1.45E-23
UVM	TF	EIF1AX	ZNF354B	0.851459656	1.44E-23
UVM	TF	EIF1AX	ZNF701	0.85193214	1.28E-23
UVM	TF	EIF1AX	ZNF800	0.852040283	1.25E-23
UVM	TF	EIF1AX	ZNF37A	0.852435633	1.13E-23
UVM	TF	EIF1AX	ZNF680	0.853312577	9.14E-24
UVM	TF	EIF1AX	BAZ2B	0.853773989	8.15E-24
UVM	TF	EIF1AX	ZNF780A	0.854390815	7.00E-24
UVM	TF	EIF1AX	ZNF226	0.855259552	5.64E-24
UVM	TF	EIF1AX	RBAK	0.855370431	5.49E-24
UVM	TF	EIF1AX	ZNF248	0.855652987	5.11E-24
UVM	TF	EIF1AX	ZBTB11	0.85571986	5.03E-24
UVM	TF	EIF1AX	ZNF141	0.856084985	4.59E-24
UVM	TF	EIF1AX	ZNF780B	0.856088327	4.58E-24
UVM	TF	EIF1AX	HDX	0.857242157	3.43E-24
UVM	TF	EIF1AX	ZNF75D	0.857400348	3.29E-24
UVM	TF	EIF1AX	ZNF10	0.857674005	3.07E-24
UVM	TF	EIF1AX	ZNF791	0.858355951	2.58E-24
UVM	TF	EIF1AX	LIN54	0.858573948	2.44E-24
UVM	TF	EIF1AX	ZNF83	0.859759383	1.80E-24
UVM	TF	EIF1AX	ZNF12	0.860142273	1.63E-24
UVM	TF	EIF1AX	ZNF449	0.860243921	1.59E-24
UVM	TF	EIF1AX	SP3	0.861059005	1.28E-24
UVM	TF	EIF1AX	ZNF254	0.861101613	1.27E-24
UVM	TF	EIF1AX	TMF1	0.861158727	1.25E-24
UVM	TF	EIF1AX	ZNF25	0.861938863	1.02E-24
UVM	TF	EIF1AX	GPBP1	0.862261172	9.37E-25
UVM	TF	EIF1AX	PCGF6	0.862638231	8.48E-25
UVM	TF	EIF1AX	ZNF267	0.862808846	8.11E-25
UVM	TF	EIF1AX	ZNF268	0.863693519	6.41E-25
UVM	TF	EIF1AX	MYNN	0.863948012	5.99E-25
UVM	TF	EIF1AX	ZNF280C	0.864690089	4.91E-25
UVM	TF	EIF1AX	ZNF845	0.864774536	4.80E-25
UVM	TF	EIF1AX	ZNF14	0.86506905	4.44E-25
UVM	TF	EIF1AX	ZNF493	0.865537256	3.91E-25
UVM	TF	EIF1AX	NFXL1	0.865552618	3.89E-25
UVM	TF	EIF1AX	ZNF148	0.86642469	3.07E-25
UVM	TF	EIF1AX	CEBPZ	0.867433986	2.33E-25
UVM	TF	EIF1AX	ZNF461	0.868275738	1.85E-25
UVM	TF	EIF1AX	ZNF43	0.870145914	1.10E-25
UVM	TF	EIF1AX	ZNF140	0.870236508	1.07E-25
UVM	TF	EIF1AX	ZNF432	0.871021199	8.59E-26
UVM	TF	EIF1AX	ELF2	0.871832348	6.83E-26
UVM	TF	EIF1AX	ZNF470	0.872311496	5.95E-26
UVM	TF	EIF1AX	ZNF84	0.873274084	4.52E-26
UVM	TF	EIF1AX	ZNF195	0.874112626	3.54E-26
UVM	TF	EIF1AX	ZNF131	0.874736453	2.96E-26
UVM	TF	EIF1AX	ZNF761	0.875559504	2.32E-26
UVM	TF	EIF1AX	ZNF24	0.876872482	1.58E-26
UVM	TF	EIF1AX	ZNF569	0.876892062	1.57E-26
UVM	TF	EIF1AX	ZNF260	0.879174054	7.90E-27
UVM	TF	EIF1AX	ZNF708	0.879955323	6.23E-27
UVM	TF	EIF1AX	ZBTB1	0.879961465	6.22E-27
UVM	TF	EIF1AX	CREB1	0.880429441	5.39E-27
UVM	TF	EIF1AX	ZNF136	0.880614704	5.09E-27
UVM	TF	EIF1AX	CREBZF	0.880639062	5.05E-27
UVM	TF	EIF1AX	ZNF441	0.881563161	3.80E-27
UVM	TF	EIF1AX	AHCTF1	0.882361783	2.97E-27
UVM	TF	EIF1AX	ZNF26	0.882944237	2.47E-27
UVM	TF	EIF1AX	IKZF5	0.88366822	1.97E-27
UVM	TF	EIF1AX	ZNF567	0.884752736	1.40E-27
UVM	TF	EIF1AX	GABPA	0.885372619	1.14E-27
UVM	TF	EIF1AX	ZNF510	0.885914095	9.62E-28
UVM	TF	EIF1AX	ZNF606	0.886118483	9.00E-28
UVM	TF	EIF1AX	SMAD5	0.886252952	8.62E-28
UVM	TF	EIF1AX	ZNF180	0.886459384	8.06E-28
UVM	TF	EIF1AX	ZNF181	0.88763423	5.50E-28
UVM	TF	EIF1AX	ZNF182	0.889445977	3.02E-28
UVM	TF	EIF1AX	THAP6	0.89011712	2.42E-28
UVM	TF	EIF1AX	ZNF280D	0.890428173	2.18E-28
UVM	TF	EIF1AX	DMTF1	0.890631135	2.03E-28
UVM	TF	EIF1AX	ZNF721	0.892700303	1.00E-28
UVM	TF	EIF1AX	ZNF566	0.893375858	7.96E-29
UVM	TF	EIF1AX	ZNF302	0.893446339	7.76E-29
UVM	TF	EIF1AX	ZNF518A	0.894316225	5.74E-29
UVM	TF	EIF1AX	ZNF527	0.895417166	3.90E-29
UVM	TF	EIF1AX	ZNF431	0.896307018	2.84E-29
UVM	TF	EIF1AX	ZNF33A	0.897052665	2.18E-29
UVM	TF	EIF1AX	ZNF28	0.898481855	1.30E-29
UVM	TF	EIF1AX	ZBTB41	0.900330248	6.56E-30
UVM	TF	EIF1AX	THAP9	0.903804427	1.76E-30
UVM	TF	EIF1AX	ZFX	0.908890643	2.33E-31
UVM	TF	EIF1AX	THAP5	0.913540344	3.31E-32
UVM	TSG	EIF1AX	PALB2	0.800319251	5.25E-19
UVM	TSG	EIF1AX	PTPN12	0.802260942	3.73E-19
UVM	TSG	EIF1AX	APC	0.803591353	2.95E-19
UVM	TSG	EIF1AX	TMEFF1	0.80387704	2.80E-19
UVM	TSG	EIF1AX	HLTF	0.806284838	1.82E-19
UVM	TSG	EIF1AX	ARID2	0.806409558	1.78E-19
UVM	TSG	EIF1AX	ITGAV	0.806839524	1.64E-19
UVM	TSG	EIF1AX	ATM	0.807168452	1.55E-19
UVM	TSG	EIF1AX	MLH3	0.809273124	1.05E-19
UVM	TSG	EIF1AX	CHUK	0.810223064	8.83E-20
UVM	TSG	EIF1AX	NEDD4	0.81152342	6.94E-20
UVM	TSG	EIF1AX	FBXW7	0.813824979	4.50E-20
UVM	TSG	EIF1AX	KDM6A	0.815737973	3.13E-20
UVM	TSG	EIF1AX	TTF1	0.816202537	2.86E-20
UVM	TSG	EIF1AX	TET2	0.817464969	2.24E-20
UVM	TSG	EIF1AX	WDR11	0.817517337	2.22E-20
UVM	TSG	EIF1AX	NAPEPLD	0.817960574	2.04E-20
UVM	TSG	EIF1AX	APAF1	0.819444692	1.53E-20
UVM	TSG	EIF1AX	USP33	0.82150858	1.02E-20
UVM	TSG	EIF1AX	INTS6	0.821738989	9.71E-21
UVM	TSG	EIF1AX	BMPR2	0.823043971	7.49E-21
UVM	TSG	EIF1AX	MSH2	0.824486093	5.60E-21
UVM	TSG	EIF1AX	RBBP8	0.827278846	3.17E-21
UVM	TSG	EIF1AX	PRKAA1	0.833532629	8.54E-22
UVM	TSG	EIF1AX	DICER1	0.834103879	7.55E-22
UVM	TSG	EIF1AX	BMPR1A	0.83562027	5.44E-22
UVM	TSG	EIF1AX	SMAD4	0.839509219	2.31E-22
UVM	TSG	EIF1AX	RINT1	0.841063857	1.63E-22
UVM	TSG	EIF1AX	PNN	0.841409004	1.51E-22
UVM	TSG	EIF1AX	GORAB	0.842448278	1.19E-22
UVM	TSG	EIF1AX	UHRF2	0.844471364	7.51E-23
UVM	TSG	EIF1AX	TOPORS	0.847853353	3.41E-23
UVM	TSG	EIF1AX	SMCHD1	0.848059924	3.24E-23
UVM	TSG	EIF1AX	COPS2	0.848608918	2.85E-23
UVM	TSG	EIF1AX	ZNF292	0.849750379	2.17E-23
UVM	TSG	EIF1AX	ZMYND11	0.84978683	2.15E-23
UVM	TSG	EIF1AX	CCAR1	0.851094036	1.57E-23
UVM	TSG	EIF1AX	FAM188A	0.854986429	6.04E-24
UVM	TSG	EIF1AX	KRIT1	0.856811829	3.82E-24
UVM	TSG	EIF1AX	CDC73	0.857773541	2.99E-24
UVM	TSG	EIF1AX	RB1CC1	0.859125947	2.12E-24
UVM	TSG	EIF1AX	SIRT1	0.859764558	1.80E-24
UVM	TSG	EIF1AX	DCLRE1A	0.860470232	1.50E-24
UVM	TSG	EIF1AX	PPM1A	0.862022672	9.98E-25
UVM	TSG	EIF1AX	PHF6	0.865946951	3.50E-25
UVM	TSG	EIF1AX	SUZ12	0.873703971	3.99E-26
UVM	TSG	EIF1AX	CUL5	0.876536796	1.74E-26
UVM	TSG	EIF1AX	LIN9	0.87683112	1.60E-26
UVM	TSG	EIF1AX	TANK	0.878338394	1.02E-26
UVM	TSG	EIF1AX	CHD1	0.878618057	9.35E-27
UVM	TSG	EIF1AX	VEZT	0.888891308	3.63E-28
UVM	TSG	EIF1AX	DMTF1	0.890631135	2.03E-28
UVM	TSG	EIF1AX	CUL2	0.903772926	1.78E-30

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
HNSC	EIF1AX	EIF1	-4.13399438210909	0.000228392819053625
PRAD	EIF1AX	EIF3A	1.13680328391952	0.000363360004697762
BRCA	EIF1AX	RPS18	-1.10158173051468	0.000391662487298429
PRAD	EIF1AX	RPS15	2.38682220239643	0.000931746432967977
KIRP	EIF1AX	RPS11	-1.01861570565103	0.00105937570333481
KIRP	EIF1AX	RPS14	-1.10710481020121	0.00114433001726866
LIHC	EIF1AX	EIF2S3	-4.62530933210412	0.00154404530385922
KICH	EIF1AX	EIF2S2	-1.06278646532411	0.00308787822723389
COAD	EIF1AX	RPS18	1.09459381578659	0.00468936562538148
BLCA	EIF1AX	EIF3A	-4.45104058307747	0.00532913208007812
LUSC	EIF1AX	RPS15	-1.54018132537089	0.00665527288479679
PRAD	EIF1AX	EIF1	1.32822648991353	0.00674237731133815
COAD	EIF1AX	RPS11	1.35307548998204	0.0312207043170929
ESCA	EIF1AX	EIF2S3	-1.31322237574718	0.0419921875
THCA	EIF1AX	RPS14	1.18855682463527	0.0484049760061147
BRCA	EIF1AX	EIF2S2	-2.57303037687825	1.70212120584918e-09
THCA	EIF1AX	RPS2	-2.9749691422722	1.8399565126656e-05
KIRC	EIF1AX	RPS2	-3.31623058345719	2.17100738110179e-12
STAD	EIF1AX	EIF2S2	-2.13186277769467	3.17529775202275e-05
KIRP	EIF1AX	RPS2	-2.72788021566791	5.12227416038514e-08
LUAD	EIF1AX	RPS2	-2.88992098496468	6.51132046672323e-08
KIRC	EIF1AX	RPS15	-1.51134139657827	6.64395189280361e-09
BRCA	EIF1AX	EIF3A	-1.218215573148	7.39403582934137e-06
KICH	EIF1AX	RPS2	-4.73426315307469	8.34465026855468e-07
KIRP	EIF1AX	RPS15	-1.53644743209735	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF1AX

IPO13, IKBKG, DCC, ELAVL1, APP, FLII, ADSL, BPGM, ASGR2, KCTD17, FAM84B, CRHBP, ERBB3, LCMT1, MRM1, RAB3IL1, NAP1L1, TGFB1, BBOX1, TFG, CRACR2A, SGOL2, AMDHD1, ACAA1, SMARCD1, CDK4, HSPB1, SUB1, NPM1, RPL10, Eif3a, Rpl35, Rrbp1, EIF1AY, NCR3LG1, PSG1, WFDC2, POF1B, PDK3, SOD1, EFTUD2, TNIP2, HEXIM1, MEPCE, LARP7, LRRK2, RFPL3, RAD18, MAP2K3, PRKD1, ESR1, NUPR1, ATG10, STAC2, STRN3, MEF2BNB, SOGA3, NEUROG3, PRKAR1A, DTNBP1, MND1, DNAJC8, HINT3, IGFBP5, NRBF2, NDUFS5, GATAD2A, FAM103A1, CTNNA3, CDC20B, FAHD2B, RNF31, TYW3, SPIN1, JUNB, nsp1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF1AX	chrX	20148655	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF1AX	chrX	20150342	C	T	single_nucleotide_variant	Likely_pathogenic	Multiple_myeloma	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF1AX	chrX	20153964	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF1AX	LGG	chrX	20156713	20156713	C	A	Missense_Mutation		8
EIF1AX	HNSC	chrX	20156731	20156731	C	T	Missense_Mutation	p.G9D	8
EIF1AX	THCA	chrX	20156735	20156735	C	T	Missense_Mutation	p.G8R	8
EIF1AX	LGG	chrX	20156713	20156713	C	T	Missense_Mutation	p.G15D	8
EIF1AX	HNSC	chrX	20156731	20156731	C	T	Missense_Mutation		5
EIF1AX	THCA	chrX	20156735	20156735	C	T	Missense_Mutation		5
EIF1AX	THCA	chrX	20156732	20156732	C	G	Missense_Mutation	p.G9R	5
EIF1AX	LGG	chrX	20156719	20156719	C	T	Missense_Mutation	p.R13H	5
EIF1AX	KIRP	chrX	20152121	20152121	C	A	Missense_Mutation	p.W70L	4
EIF1AX	UVM	chrX	20156740	20156740	C	T	Missense_Mutation		4
EIF1AX	UVM	chrX	20156740	20156740	C	T	Missense_Mutation	p.G6D	4
EIF1AX	THCA	chrX	20148726	20148726	C	A	Splice_Site		3
EIF1AX	THYM	chrX	20159748	20159748	T	C	Missense_Mutation	p.N4S	3
EIF1AX	UVM	chrX	20152122	20152122	A	T	Missense_Mutation	p.W70R	3
EIF1AX	THCA	chrX	20156732	20156732	C	G	Missense_Mutation		3
EIF1AX	UCEC	chrX	20159755	20159755	G	A	Missense_Mutation	p.P2S	3
EIF1AX	BRCA	chrX	20148683	20148683	T	G	Missense_Mutation	p.D127A	3
EIF1AX	BRCA	chrX	20148714	20148714	C	A	Nonsense_Mutation	p.E117*	3
EIF1AX	LGG	chrX	20156729	20156729	T	C	Missense_Mutation	p.K10E	3
EIF1AX	SARC	chrX	20156712	20156712	A	G	Silent		2
EIF1AX	LGG	chrX	20156729	20156729	T	C	Missense_Mutation		2
EIF1AX	UVM	chrX	20156740	20156740	C	T	Splice_Site	p.G6_splice	2
EIF1AX	SKCM	chrX	20156723	20156723	T	C	Missense_Mutation	p.R12G	2
EIF1AX	LIHC	chrX	20156687	20156687	T	-	Frame_Shift_Del	p.R24fs	2
EIF1AX	UCEC	chrX	20150319	20150319	G	A	Silent	p.Y106	2
EIF1AX	SKCM	chrX	20156737	20156737	T	C	Missense_Mutation	p.K7R	2
EIF1AX	UCEC	chrX	20150343	20150343	G	A	Silent	p.D98	2
EIF1AX	UCEC	chrX	20152109	20152109	G	A	Missense_Mutation	p.S74L	2
EIF1AX	CESC	chrX	20156734	20156734	C	T	Missense_Mutation		2
EIF1AX	STAD	chrX	20153904	20153904	G	A	Silent	p.F52F	2
EIF1AX	LGG	chrX	20156713	20156713	C	A	Missense_Mutation	p.G15V	2
EIF1AX	LUAD	chrX	20156717	20156717	T	A	Missense_Mutation	p.R14W	2
EIF1AX	UVM	chrX	20152122	20152122	A	T	Missense_Mutation		2
EIF1AX	STAD	chrX	20153954	20153954	C	T	Missense_Mutation	p.A36T	2
EIF1AX	LUAD	chrX	20148716	20148716	T	C	Missense_Mutation	p.N116S	2
EIF1AX	COAD	chrX	20152120	20152120	C	A	Missense_Mutation	p.W70C	2
EIF1AX	LUAD	chrX	20153879	20153879	T	G	Missense_Mutation	p.I61L	2
EIF1AX	GBM	chrX	20148634	20148634	G	A	Silent		1
EIF1AX	THYM	chrX	20159743	20159743	C	T	Missense_Mutation	p.G6S	1
EIF1AX	SARC	chrX	20156712	20156712	A	G	Silent	p.G15G	1
EIF1AX	UVM	chrX	20156735	20156737	CTT	-	In_Frame_Del	p.7_8del	1
EIF1AX	HNSC	chrX	20153883	20153883	A	G	Silent	p.C59C	1
EIF1AX	LGG	chrX	20150322	20150322	T	C	Silent		1
EIF1AX	THYM	chrX	20159743	20159743	C	T	Splice_Site	p.G6_splice	1
EIF1AX	SARC	chrX	20156712	20156712	A	G	Silent	p.G15	1
EIF1AX	LIHC	chrX	20152085	20152086	-	G	Frame_Shift_Ins	p.R82fs	1
EIF1AX	UVM	chrX	20156735	20156737	CTT	-	In_Frame_Del	p.KG7del	1
EIF1AX	KIRP	chrX	20152121	20152121	C	A	Missense_Mutation		1
EIF1AX	THCA	chrX	20148725	20148725	G	A	Missense_Mutation	p.A113V	1
EIF1AX	LIHC	chrX	20159753	20159753	G	-	Frame_Shift_Del	p.P2fs	1
EIF1AX	UVM	chrX	20156735	20156737	CTT	-	In_Frame_Del	p.7_8KG>R	1
EIF1AX	STAD	chrX	20153904	20153904	G	A	Silent		1
EIF1AX	THCA	chrX	20148725	20148725	G	A	Splice_Site	p.A113_splice	1
EIF1AX	LIHC	chrX	20159750	20159750	C	-	Frame_Shift_Del	p.K3fs	1
EIF1AX	THCA	chrX	20148693	20148693	C	A	Nonsense_Mutation	p.G124*	1
EIF1AX	CESC	chrX	20156734	20156734	C	T	Missense_Mutation	p.G8E	1
EIF1AX	THCA	chrX	20148692	20148692	C	A	Missense_Mutation	p.G124V	1
EIF1AX	UVM	chrX	20156735	20156737	CTT	-	In_Frame_Del		1
EIF1AX	STAD	chrX	20153899	20153899	C	T	Missense_Mutation	p.G54D	1
EIF1AX	THYM	chrX	20159743	20159743	C	T	Missense_Mutation		1
EIF1AX	GBM	chrX	20148634	20148634	G	A	Silent	p.D143_splice	1
EIF1AX	THCA	chrX	20148725	20148725	G	A	Missense_Mutation		1
EIF1AX	LGG	chrX	20150322	20150322	T	C	Silent	p.A105A	1
EIF1AX	THYM	chrX	20159748	20159748	T	C	Missense_Mutation		1
EIF1AX	OV	chrX	20156742	20156742	T	G	Splice_Site	p.G6_splice	1

Copy number variation (CNV) of EIF1AX
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF1AX
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
70718	N/A	AW021788	EIF1AX	chrX	20145171	-	LAMTOR4	chr7	99748682	+
101120	Non-Cancer	ERR315461	EIF1AX	chrX	20153856	-	RPS6KA3	chrX	20181158	-
78002	N/A	BQ436116	GLIS2	chr16	4388373	+	EIF1AX	chrX	20144883	-
78012	LIHC	TCGA-DD-AADJ	RPS6KA3	chrX	20284681	-	EIF1AX	chrX	20153959	-
78012	LIHC	TCGA-DD-AADJ-01A	RPS6KA3	chrX	20284682	-	EIF1AX	chrX	20153959	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	EIF1AX	0.000108793938804378	0.00087
READ	EIF1AX	0.000258215651555145	0.0018
DLBC	EIF1AX	0.00166641995401666	0.01
TGCT	EIF1AX	0.00277568562871128	0.014
MESO	EIF1AX	0.0028305435721782	0.014
KICH	EIF1AX	0.00288860445800327	0.014
ACC	EIF1AX	0.0107649745498549	0.022
UVM	EIF1AX	0.0497203678312722	0.05
HNSC	EIF1AX	1.29916502874391e-23	3.2e-22
LGG	EIF1AX	1.44508568940423e-18	2.9e-17
THYM	EIF1AX	1.52060568553715e-12	2.6e-11
SKCM	EIF1AX	1.69114082258999e-08	2e-07
PCPG	EIF1AX	1.98818472587858e-06	2.2e-05
PAAD	EIF1AX	2.21229630465337e-19	4.6e-18
COAD	EIF1AX	2.31136040588553e-10	3.7e-09
GBM	EIF1AX	2.82283537456721e-10	4.2e-09
KIRC	EIF1AX	3.20638483309479e-35	8.7e-34
THCA	EIF1AX	3.46371263958515e-42	9.7e-41
STAD	EIF1AX	3.82745665742077e-15	7.3e-14
LIHC	EIF1AX	3.8619391003703e-31	1e-29
BLCA	EIF1AX	3.86758871714594e-15	7.3e-14
LAML	EIF1AX	3.97200011804536e-10	5.6e-09
CHOL	EIF1AX	4.72585065537341e-06	4.7e-05
ESCA	EIF1AX	5.24398357787519e-05	0.00047
KIRP	EIF1AX	6.74842170757809e-20	1.5e-18
LUSC	EIF1AX	7.35665393269603e-22	1.7e-20
LUAD	EIF1AX	9.58249165731062e-23	2.3e-21
SARC	EIF1AX	9.77046867613854e-09	1.3e-07

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	EIF1AX	0.0022718539595365	0.073
KIRC	EIF1AX	0.00309953998388223	0.096
OV	EIF1AX	1.19222586268758e-05	0.00039
BLCA	EIF1AX	0.0362405683464093	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0220633	Uveal melanoma	1	CTD_human
C0238463	Papillary thyroid carcinoma	1	ORPHANET