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Translation Factor: EIF2S3 (NCBI Gene ID:1968) |
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Gene Summary |
Gene Information | Gene Name: EIF2S3 | Gene ID: 1968 | Gene Symbol | EIF2S3 | Gene ID | 1968 |
Gene Name | eukaryotic translation initiation factor 2 subunit gamma | |
Synonyms | EIF2|EIF2G|EIF2gamma|MEHMO|MRXSBRK|eIF-2gA | |
Cytomap | Xp22.11 | |
Type of Gene | protein-coding | |
Description | eukaryotic translation initiation factor 2 subunit 3eIF-2-gamma XeIF-2gXeukaryotic translation initiation factor 2 subunit gamma Xeukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaeukaryotic translation initiation factor 2G | |
Modification date | 20200313 | |
UniProtAcc | P41091 |
Child GO biological process term(s) under GO:0006412 |
GO ID | GO term |
GO:0006417 | Regulation of translation |
GO:0008135 | Translation factor activity, RNA binding |
GO:0045727 | Positive regulation of translation |
GO:0002181 | Cytoplasmic translation |
GO:0006413 | Translational initiation |
GO:0006412 | Translation |
Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF2S3 | GO:0006413 | translational initiation | 10900014 |
Inferred gene age of translation factor. |
Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
EIF2S3 | >1119.25 |
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We searched PubMed using 'EIF2S3[title] AND translation [title] AND human.' |
Gene | Title | PMID |
EIF2S3 | MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2 | 30517694 |
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Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
ENST00000253039 | 24078204 | 24078299 | Frame-shift |
ENST00000253039 | 24080532 | 24080691 | In-frame |
ENST00000253039 | 24082317 | 24082452 | In-frame |
ENST00000253039 | 24084114 | 24084209 | Frame-shift |
ENST00000253039 | 24086080 | 24086225 | Frame-shift |
ENST00000253039 | 24089674 | 24089844 | Frame-shift |
ENST00000253039 | 24091207 | 24091380 | Frame-shift |
Exon skipping position in the amino acid sequence. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
ENST00000253039 | 24080532 | 24080691 | 2875 | 732 | 890 | 472 | 159 | 212 |
ENST00000253039 | 24082317 | 24082452 | 2875 | 891 | 1025 | 472 | 212 | 257 |
Potentially (partially) lost protein functional features of UniProt. |
UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
P41091 | 159 | 212 | 2 | 472 | Chain | ID=PRO_0000137438;Note=Eukaryotic translation initiation factor 2 subunit 3 |
P41091 | 212 | 257 | 2 | 472 | Chain | ID=PRO_0000137438;Note=Eukaryotic translation initiation factor 2 subunit 3 |
P41091 | 159 | 212 | 39 | 248 | Domain | Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059 |
P41091 | 212 | 257 | 39 | 248 | Domain | Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059 |
P41091 | 159 | 212 | 190 | 193 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
P41091 | 159 | 212 | 190 | 193 | Region | Note=G4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059 |
P41091 | 212 | 257 | 225 | 227 | Region | Note=G5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059 |
P41091 | 212 | 257 | 222 | 222 | Natural variant | ID=VAR_077139;Note=In MEHMO%3B decreased interaction with the other eIF2 complex subunits EIF2S1 and EIF2S2. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23063529;Dbxref=dbSNP:rs886040855,PMID:23063529 |
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Gene expression level across TCGA pancancer |
Gene expression level across GTEx pantissue |
Expression level of gene isoforms across TCGA pancancer |
Expression level of gene isoforms across GTEx pantissue |
Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
Cancer type | Translation factor | FC | adj.pval |
LIHC | EIF2S3 | -4.62530933210412 | 0.00154404530385922 |
ESCA | EIF2S3 | -1.31322237574718 | 0.0419921875 |
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Translation factor expression regulation through miRNA binding |
Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
Translation factor expression regulation through methylation in the promoter of Translation factor |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through copy number variation of Translation factor |
Cancer type | Gene | Coefficient | Pvalue |
PAAD | EIF2S3 | -0.303408041 | 0.002265862 |
SKCM | EIF2S3 | -0.031584333 | 0.038957074 |
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Strongly correlated genes belong to cellular important gene groups with EIF2S3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
CHOL | Cell metabolism gene | EIF2S3 | SLC25A6 | 0.838706284 | 6.40E-13 |
CHOL | IUPHAR | EIF2S3 | SLC25A6 | 0.838706284 | 6.40E-13 |
UVM | TSG | EIF2S3 | RBMX | 0.81050733 | 8.38E-20 |
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Protein 3D structure Visit iCn3D. |
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Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
* Edge colors based on TCGA cancer types. |
* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
LIHC | EIF2S3 | EIF2B5 | -2.17335102876885 | 0.000112780019881286 |
KICH | EIF2S3 | EIF2B3 | 2.17795043401278 | 0.000216901302337646 |
HNSC | EIF2S3 | EIF1 | -4.13399438210909 | 0.000228392819053625 |
PRAD | EIF2S3 | EIF3A | 1.13680328391952 | 0.000363360004697762 |
THCA | EIF2S3 | EIF2B3 | -2.27193247701228 | 0.000372452864704637 |
BRCA | EIF2S3 | EIF5 | -1.16704316213885 | 0.00107943958337404 |
KICH | EIF2S3 | EIF2S2 | -1.06278646532411 | 0.00308787822723389 |
HNSC | EIF2S3 | EIF2B3 | -1.66956934127194 | 0.00459462782941955 |
KIRP | EIF2S3 | EIF3G | -2.4178322962129 | 0.00471024587750435 |
BLCA | EIF2S3 | EIF3A | -4.45104058307747 | 0.00532913208007812 |
PRAD | EIF2S3 | EIF1 | 1.32822648991353 | 0.00674237731133815 |
COAD | EIF2S3 | EIF2B3 | -1.60183733464354 | 0.00938254594802858 |
COAD | EIF2S3 | EIF2B5 | -3.82949281161428 | 0.011966735124588 |
CHOL | EIF2S3 | EIF2B2 | -1.61211785827489 | 0.02734375 |
UCEC | EIF2S3 | EIF3G | -3.35078334696571 | 0.03125 |
BLCA | EIF2S3 | EIF3G | -3.07707559649091 | 0.0323410034179688 |
LUAD | EIF2S3 | EIF3B | -5.80435587546762 | 1.0542655358657e-09 |
BRCA | EIF2S3 | EIF2S2 | -2.57303037687825 | 1.70212120584918e-09 |
BRCA | EIF2S3 | EIF3G | 1.87948385011271 | 1.9107949115022e-06 |
KIRC | EIF2S3 | EIF3B | -1.56313263784517 | 2.35252849767166e-12 |
STAD | EIF2S3 | EIF2S2 | -2.13186277769467 | 3.17529775202275e-05 |
STAD | EIF2S3 | EIF3B | -4.7724660972007 | 3.25962901115418e-08 |
LIHC | EIF2S3 | EIF2B2 | -1.75683032348821 | 4.08414278982391e-05 |
LUAD | EIF2S3 | EIF2B2 | -3.96081365689084 | 4.19177862905507e-09 |
HNSC | EIF2S3 | EIF3B | 2.6202554263604 | 4.48234413852334e-06 |
KIRP | EIF2S3 | EIF3B | -2.7592297042974 | 4.6566128730774e-09 |
LIHC | EIF2S3 | EIF5 | -2.12060405382854 | 4.66164898670786e-08 |
BRCA | EIF2S3 | EIF2B3 | -1.42398409637427 | 6.27134207487183e-10 |
BRCA | EIF2S3 | EIF3A | -1.218215573148 | 7.39403582934137e-06 |
Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
PPI interactors with EIF2S3 |
EIF1B, CASP4, DCC, RAD21, NDRG1, HDGF, ELAVL1, CDK2, CAND1, GRK5, EIF2S1, FN1, MAPK6, TARDBP, AIMP1, AIP, DNAJA1, EEF1E1, QARS, RARS, IMPDH2, IQGAP1, CCAR2, PLD3, rev, RNF2, EIF2S2, UNK, ABCF2, GTPBP1, HBS1L, POLR1B, SUB1, RPS4X, WIBG, NTRK1, XPO1, DNAJC7, NOP56, Hsph1, Rrbp1, Bag2, NF2, Ksr1, C1orf131, CDC73, CDH1, CYLD, TRIM25, KRAS, PRPF8, EFTUD2, AAR2, RIOK1, ESR2, AGR2, CDK9, RPS6KB2, KRT17, PHB, NRAS, MAPT, NR2C2, PRMT7, PSMD14, CD74, DDX60, MAB21L2, SNRNP70, ITFG1, BIRC3, STAU1, NFX1, BRD7, TP53, TRIM28, PLEKHA4, N, HCVgp1, ZC3H18, ATRX, M, nsp13, nsp14, nsp4, nsp6, ORF3a, ORF7b, ESR1, NEK4, DUX4, NDN, BRD4, NUPR1, C18orf8, nsp3, Apc2, LGALS9, IFI16, BKRF1, CD274, UFL1, DDRGK1, AKAP1, ANAPC2, DHFRL1, EIF6, LAMTOR1, POLR2C, FZR1, WDR5, NAA40, CDC123, SPRTN, BTF3, FBXW7, FURIN, IFITM1, IFITM3, E, ORF10, ORF6, ORF8, S, CCNF, SQSTM1, |
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Clinically associated variants from ClinVar. |
Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
EIF2S3 | chrX | 24073090 | C | G | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24073091 | G | T | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24073113 | C | T | single_nucleotide_variant | Likely_benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24073761 | C | T | single_nucleotide_variant | Benign | MEHMO_syndrome|not_specified|not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24073785 | A | G | single_nucleotide_variant | Benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24073803 | T | C | single_nucleotide_variant | Benign/Likely_benign | not_specified|not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
EIF2S3 | chrX | 24075532 | C | G | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
EIF2S3 | chrX | 24075534 | A | G | single_nucleotide_variant | Likely_benign | not_specified | SO:0001627|intron_variant | SO:0001627|intron_variant |
EIF2S3 | chrX | 24075762 | G | A | single_nucleotide_variant | Uncertain_significance | Inborn_genetic_diseases | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24075777 | C | T | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24075794 | T | C | single_nucleotide_variant | Likely_benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24075812 | T | A | single_nucleotide_variant | Uncertain_significance | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24075862 | A | G | single_nucleotide_variant | Likely_benign | not_specified | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24075867 | G | A | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24078238 | T | C | single_nucleotide_variant | Likely_benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24078252 | C | T | single_nucleotide_variant | Likely_pathogenic | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24078254 | A | G | single_nucleotide_variant | Likely_pathogenic | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24082345 | T | C | single_nucleotide_variant | Pathogenic | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24082350 | A | G | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24082355 | A | G | single_nucleotide_variant | Likely_benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24084119 | T | G | single_nucleotide_variant | Pathogenic | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24084139 | A | T | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24084162 | C | G | single_nucleotide_variant | Likely_pathogenic | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24084216 | T | C | single_nucleotide_variant | Likely_benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
EIF2S3 | chrX | 24086125 | T | C | single_nucleotide_variant | Benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24086142 | T | A | single_nucleotide_variant | Uncertain_significance | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24086179 | T | C | single_nucleotide_variant | Likely_benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24086216 | G | A | single_nucleotide_variant | Likely_pathogenic | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
EIF2S3 | chrX | 24091193 | A | G | single_nucleotide_variant | Uncertain_significance | MEHMO_syndrome | SO:0001627|intron_variant | SO:0001627|intron_variant |
EIF2S3 | chrX | 24091291 | C | T | single_nucleotide_variant | Benign | not_specified|not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24091339 | A | G | single_nucleotide_variant | Benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
EIF2S3 | chrX | 24094873 | ACAAT | A | Deletion | Pathogenic/Likely_pathogenic | MEHMO_syndrome|not_provided | SO:0001589|frameshift_variant | SO:0001589|frameshift_variant |
EIF2S3 | chrX | 24094886 | C | G | single_nucleotide_variant | Uncertain_significance | MEHMO_syndrome | SO:0001583|missense_variant | SO:0001583|missense_variant |
nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
SNVs and Indels |
Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
EIF2S3 | ESCA | chrX | 24075597 | 24075597 | C | T | Missense_Mutation | p.H65Y | 6 |
EIF2S3 | BLCA | chrX | 24073777 | 24073777 | C | A | Missense_Mutation | 5 | |
EIF2S3 | KIRP | chrX | 24089815 | 24089815 | C | T | Missense_Mutation | p.R385C | 4 |
EIF2S3 | UCEC | chrX | 24091292 | 24091292 | G | T | Missense_Mutation | p.D423Y | 3 |
EIF2S3 | UCEC | chrX | 24075832 | 24075832 | C | T | Missense_Mutation | p.T115M | 3 |
EIF2S3 | UCEC | chrX | 24075780 | 24075780 | C | T | Missense_Mutation | p.R98W | 3 |
EIF2S3 | BRCA | chrX | 24082440 | 24082440 | C | A | Missense_Mutation | p.P254T | 3 |
EIF2S3 | BLCA | chrX | 24086216 | 24086216 | G | A | Missense_Mutation | p.G335S | 3 |
EIF2S3 | SKCM | chrX | 24089794 | 24089794 | C | T | Missense_Mutation | p.L378F | 2 |
EIF2S3 | SKCM | chrX | 24089795 | 24089795 | T | A | Missense_Mutation | p.L378H | 2 |
EIF2S3 | BLCA | chrX | 24075862 | 24075862 | A | G | Missense_Mutation | 2 | |
EIF2S3 | SKCM | chrX | 24086119 | 24086119 | C | T | Silent | p.S302S | 2 |
EIF2S3 | LUAD | chrX | 24094881 | 24094881 | G | T | Missense_Mutation | p.K466N | 2 |
EIF2S3 | BRCA | chrX | 24082437 | 24082437 | G | A | Missense_Mutation | p.E253K | 2 |
EIF2S3 | UCEC | chrX | 24073092 | 24073092 | G | A | Missense_Mutation | p.G3S | 2 |
EIF2S3 | ESCA | chrX | 24091268 | 24091268 | G | T | Missense_Mutation | p.G415W | 2 |
EIF2S3 | STAD | chrX | 24089745 | 24089745 | C | T | Silent | 2 | |
EIF2S3 | LIHC | chrX | 24084190 | 24084190 | T | C | Missense_Mutation | 2 | |
EIF2S3 | UCEC | chrX | 24073733 | 24073733 | A | G | Missense_Mutation | p.D24G | 2 |
EIF2S3 | ESCA | chrX | 24075597 | 24075597 | C | T | Missense_Mutation | 2 | |
EIF2S3 | STAD | chrX | 24086195 | 24086195 | C | T | Silent | p.L328L | 2 |
EIF2S3 | CESC | chrX | 24089770 | 24089770 | G | A | Missense_Mutation | 2 | |
EIF2S3 | LIHC | chrX | 24084190 | 24084190 | T | C | Missense_Mutation | p.I283T | 2 |
EIF2S3 | UCEC | chrX | 24080667 | 24080667 | G | A | Missense_Mutation | p.E205K | 2 |
EIF2S3 | PRAD | chrX | 24075812 | 24075812 | T | C | Silent | p.S108S | 2 |
EIF2S3 | STAD | chrX | 24089745 | 24089745 | C | T | Silent | p.V361V | 2 |
EIF2S3 | KICH | chrX | 24075766 | 24075766 | A | G | Missense_Mutation | p.D93G | 2 |
EIF2S3 | CESC | chrX | 24094872 | 24094872 | G | A | Silent | 2 | |
EIF2S3 | LIHC | chrX | 24086213 | 24086213 | G | - | Frame_Shift_Del | p.G335fs | 2 |
EIF2S3 | UCEC | chrX | 24082445 | 24082445 | G | A | Silent | p.R255 | 2 |
EIF2S3 | STAD | chrX | 24086182 | 24086182 | G | A | Silent | p.A323A | 2 |
EIF2S3 | LIHC | chrX | 24091341 | 24091341 | A | - | Frame_Shift_Del | p.E439fs | 2 |
EIF2S3 | UCEC | chrX | 24091279 | 24091279 | T | C | Silent | p.S418 | 2 |
EIF2S3 | BLCA | chrX | 24084129 | 24084129 | G | C | Missense_Mutation | p.D263H | 2 |
EIF2S3 | LIHC | chrX | 24086175 | 24086175 | T | - | Frame_Shift_Del | p.L321fs | 2 |
EIF2S3 | GBM | chrX | 24073154 | 24073154 | G | A | Silent | p.L23_splice | 1 |
EIF2S3 | BLCA | chrX | 24086205 | 24086205 | C | T | Missense_Mutation | p.A331V | 1 |
EIF2S3 | COAD | chrX | 24086128 | 24086128 | T | C | Silent | p.S305S | 1 |
EIF2S3 | LIHC | chrX | 24086120 | 24086120 | A | - | Frame_Shift_Del | p.K303fs | 1 |
EIF2S3 | GBM | chrX | 24075581 | 24075581 | A | T | Missense_Mutation | p.K59N | 1 |
EIF2S3 | BLCA | chrX | 24091329 | 24091329 | C | T | Missense_Mutation | p.T435I | 1 |
EIF2S3 | KIRP | chrX | 24089815 | 24089815 | C | T | Missense_Mutation | 1 | |
EIF2S3 | UCEC | chrX | 24091379 | 24091379 | C | T | Missense_Mutation | p.R452_splice | 1 |
EIF2S3 | COAD | chrX | 24091214 | 24091214 | A | G | Missense_Mutation | p.K397E | 1 |
EIF2S3 | LUAD | chrX | 24094891 | 24094891 | G | T | Missense_Mutation | p.D470Y | 1 |
EIF2S3 | BLCA | chrX | 24086216 | 24086216 | G | A | Missense_Mutation | 1 | |
EIF2S3 | GBM | chrX | 24089786 | 24089786 | A | T | Missense_Mutation | 1 | |
EIF2S3 | BLCA | chrX | 24086096 | 24086096 | G | A | Missense_Mutation | p.E295K | 1 |
EIF2S3 | LGG | chrX | 24075552 | 24075552 | G | A | Missense_Mutation | p.V50I | 1 |
EIF2S3 | DLBC | chrX | 24073785 | 24073785 | A | G | Silent | p.T41T | 1 |
EIF2S3 | SKCM | chrX | 24075645 | 24075645 | C | T | Missense_Mutation | p.L81F | 1 |
EIF2S3 | BLCA | chrX | 24084129 | 24084129 | G | C | Missense_Mutation | 1 | |
EIF2S3 | GBM | chrX | 24075581 | 24075581 | A | T | Missense_Mutation | 1 | |
EIF2S3 | LGG | chrX | 24084146 | 24084146 | C | A | Silent | p.G268G | 1 |
EIF2S3 | LUSC | chrX | 24078262 | 24078262 | C | T | Silent | p.N147N | 1 |
EIF2S3 | SKCM | chrX | 24086118 | 24086118 | C | T | Missense_Mutation | p.S302F | 1 |
EIF2S3 | BLCA | chrX | 24073096 | 24073096 | G | A | Missense_Mutation | 1 | |
EIF2S3 | HNSC | chrX | 24091373 | 24091373 | C | T | Missense_Mutation | 1 | |
EIF2S3 | LIHC | chrX | 24078262 | 24078262 | C | T | Silent | 1 | |
EIF2S3 | OV | chrX | 23996091 | 23996091 | A | T | Silent | 1 | |
EIF2S3 | SARC | chrX | 24075644 | 24075644 | G | T | Missense_Mutation | 1 | |
EIF2S3 | BLCA | chrX | 24080591 | 24080591 | C | T | Silent | 1 | |
EIF2S3 | HNSC | chrX | 24091373 | 24091373 | C | T | Missense_Mutation | p.H450Y | 1 |
EIF2S3 | CESC | chrX | 24086129 | 24086129 | G | A | Missense_Mutation | 1 | |
EIF2S3 | PAAD | chrX | 24075575 | 24075575 | C | A | Silent | 1 | |
EIF2S3 | SARC | chrX | 24084145 | 24084145 | G | T | Missense_Mutation | 1 | |
EIF2S3 | BLCA | chrX | 24091329 | 24091329 | C | T | Missense_Mutation | 1 | |
EIF2S3 | KICH | chrX | 24075766 | 24075766 | A | G | Missense_Mutation | 1 | |
EIF2S3 | ESCA | chrX | 24091268 | 24091268 | G | T | Missense_Mutation | 1 | |
EIF2S3 | SARC | chrX | 24089749 | 24089749 | G | T | Missense_Mutation | 1 | |
EIF2S3 | BLCA | chrX | 24086096 | 24086096 | G | A | Missense_Mutation | 1 | |
EIF2S3 | ESCA | chrX | 24089816 | 24089816 | G | T | Missense_Mutation | p.R385L | 1 |
EIF2S3 | SARC | chrX | 24075758 | 24075758 | G | T | Missense_Mutation | 1 | |
EIF2S3 | SARC | chrX | 24091349 | 24091349 | G | T | Missense_Mutation | 1 | |
EIF2S3 | KIRC | chrX | 24073090 | 24073091 | - | GGG | In_Frame_Ins | p.A2delinsAG | 1 |
EIF2S3 | CESC | chrX | 24089770 | 24089770 | G | A | Missense_Mutation | p.E370K | 1 |
EIF2S3 | ESCA | chrX | 24089724 | 24089724 | G | T | Silent | p.V354V | 1 |
EIF2S3 | SARC | chrX | 24089749 | 24089749 | G | T | Missense_Mutation | p.A363S | 1 |
EIF2S3 | KIRC | chrX | 24091372 | 24091372 | A | T | Missense_Mutation | p.K449N | 1 |
EIF2S3 | TGCT | chrX | 24073761 | 24073761 | C | T | Silent | 1 | |
EIF2S3 | CESC | chrX | 24094872 | 24094872 | G | A | Silent | p.V463 | 1 |
EIF2S3 | GBM | chrX | 24094874 | 24094877 | CAAT | - | Frame_Shift_Del | p.T464fs | 1 |
EIF2S3 | SARC | chrX | 24075758 | 24075758 | G | T | Missense_Mutation | p.K90N | 1 |
EIF2S3 | BLCA | chrX | 24073096 | 24073096 | G | A | Missense_Mutation | p.G4E | 1 |
EIF2S3 | KIRC | chrX | 24084113 | 24084113 | A | T | Splice_Site | 1 | |
EIF2S3 | THYM | chrX | 24078291 | 24078291 | T | C | Missense_Mutation | p.L157P | 1 |
EIF2S3 | COAD | chrX | 24073761 | 24073761 | C | T | Silent | p.H33H | 1 |
EIF2S3 | LIHC | chrX | 24089724 | 24089724 | G | - | Frame_Shift_Del | p.V354fs | 1 |
Copy number variation (CNV) of EIF2S3 * Click on the image to open the original image in a new window. |
Fusion gene breakpoints (product of the structural variants (SVs)) across EIF2S3 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion genes with this translation factor from FusionGDB2.0. |
FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
95399 | N/A | BG774247 | EIF2S3 | chrX | 24095884 | - | H19 | chr11 | 2019057 | - |
98974 | N/A | AI830759 | EIF2S3 | chrX | 24095226 | + | HNRNPA3 | chr2 | 178087487 | + |
98844 | N/A | BQ371816 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
90464 | N/A | BF858913 | EIF2S3 | chrX | 24094526 | - | NR2C2 | chr3 | 14993253 | + |
78669 | STAD | TCGA-CG-5718 | EIF2S3 | chrX | 24078299 | + | PRDX4 | chrX | 23704401 | + |
78669 | STAD | TCGA-CG-5718-01A | EIF2S3 | chrX | 24078299 | + | PRDX4 | chrX | 23704402 | + |
101140 | N/A | AA460998 | FAM213A | chr10 | 82192088 | + | EIF2S3 | chrX | 24095449 | + |
101140 | N/A | AW580222 | GFPT1 | chr2 | 69560231 | + | EIF2S3 | chrX | 24080683 | - |
101140 | Non-Cancer | TCGA-HU-A4GC-11A | MLTK | chr2 | 174090042 | + | EIF2S3 | chrX | 24095464 | + |
101140 | SARC | TCGA-DX-A1KY-01A | PDK3 | chrX | 24483678 | + | EIF2S3 | chrX | 24073732 | + |
101140 | N/A | BP430336 | TUBA1B | chr12 | 49522545 | - | EIF2S3 | chrX | 24095269 | - |
101146 | UCEC | TCGA-AX-A3G4 | ZFX | chrX | 24167911 | + | EIF2S3 | chrX | 24089674 | + |
101146 | UCEC | TCGA-AX-A3G4-01A | ZFX | chrX | 24167911 | + | EIF2S3 | chrX | 24089675 | + |
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Kaplan-Meier plots with logrank tests of overall survival (OS) |
Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
GBM | EIF2S3 | 0.000119044160811642 | 0.0015 |
ESCA | EIF2S3 | 0.00038883853054575 | 0.0047 |
MESO | EIF2S3 | 0.000504050003878022 | 0.0055 |
BRCA | EIF2S3 | 0.000578233543098314 | 0.0058 |
LUAD | EIF2S3 | 0.00168866355477819 | 0.015 |
ACC | EIF2S3 | 0.00350019395854102 | 0.028 |
CHOL | EIF2S3 | 0.00839173144390323 | 0.059 |
DLBC | EIF2S3 | 0.0168326098953598 | 0.1 |
COAD | EIF2S3 | 0.0318457983395009 | 0.16 |
LAML | EIF2S3 | 1.18868734305814e-05 | 2e-04 |
SARC | EIF2S3 | 1.2054221418744e-07 | 2.5e-06 |
LGG | EIF2S3 | 1.28681854560967e-19 | 3.5e-18 |
PAAD | EIF2S3 | 2.03351569452554e-05 | 0.00033 |
KIRP | EIF2S3 | 2.21119153047962e-15 | 5.7e-14 |
STAD | EIF2S3 | 2.61278950217271e-07 | 5.2e-06 |
LIHC | EIF2S3 | 2.98398165297351e-05 | 0.00045 |
SKCM | EIF2S3 | 3.49286799825527e-06 | 6.3e-05 |
LUSC | EIF2S3 | 3.97742951682647e-09 | 9.1e-08 |
THCA | EIF2S3 | 4.26796563240378e-20 | 1.2e-18 |
BLCA | EIF2S3 | 4.99378359125826e-09 | 1.1e-07 |
PCPG | EIF2S3 | 5.85596001714123e-05 | 0.00082 |
THYM | EIF2S3 | 6.46740810705517e-10 | 1.6e-08 |
HNSC | EIF2S3 | 8.1218392446105e-14 | 2e-12 |
KIRC | EIF2S3 | 9.94881730377697e-07 | 1.9e-05 |
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Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
OV | EIF2S3 | 0.00013352715546737 | 0.0044 |
ACC | EIF2S3 | 0.00211578851493571 | 0.068 |
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Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Diseases associated with this translation factor. (DisGeNet 4.0) |
Disease ID | Disease Name | # PubMeds | Disease source |
C1846278 | MENTAL RETARDATION, EPILEPTIC SEIZURES, HYPOGONADISM AND HYPOGENITALISM, MICROCEPHALY, AND OBESITY (disorder) | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
C0011847 | Diabetes | 1 | GENOMICS_ENGLAND |
C0014544 | Epilepsy | 1 | GENOMICS_ENGLAND |
C0020619 | Hypogonadism | 1 | GENOMICS_ENGLAND |
C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND |