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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF4EBP1 (NCBI Gene ID:1978)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF4EBP1
	Gene ID: 1978
	Gene Symbol	EIF4EBP1
	Gene ID	1978
	Gene Name	eukaryotic translation initiation factor 4E binding protein 1
	Synonyms	4E-BP1\|4EBP1\|BP-1\|PHAS-I
	Cytomap	8p11.23
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 4E-binding protein 1eIF4E-binding protein 1phosphorylated heat- and acid-stable protein regulated by insulin 1
	Modification date	20200322
	UniProtAcc	Q13541

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF4EBP1	GO:0031929	TOR signaling	12150926\|22578813
Hgene	EIF4EBP1	GO:0045947	negative regulation of translational initiation	22578813

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF4EBP1	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'EIF4EBP1[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF4EBP1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	EIF4EBP1	-1.52730406636296	0.00170492480464144
HNSC	EIF4EBP1	1.16888194926653	0.0196738412400919
KIRP	EIF4EBP1	-2.1223854491688	2.98023223876953e-07
LUAD	EIF4EBP1	-2.82691479456829	6.51132046672323e-08
BRCA	EIF4EBP1	-1.867430312542	8.26346922422571e-07
KIRC	EIF4EBP1	-3.14860466879601	9.40007073737459e-12

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CHOL	EIF4EBP1	-0.082174008	0.014843092

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF4EBP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	EIF4EBP1	PMM2	0.802998013	9.61E-29
THYM	Cell metabolism gene	EIF4EBP1	SLC27A5	0.803290122	8.87E-29
THYM	Cell metabolism gene	EIF4EBP1	TOMM40	0.805071358	5.44E-29
THYM	Cell metabolism gene	EIF4EBP1	TSTA3	0.805341062	5.05E-29
THYM	Cell metabolism gene	EIF4EBP1	MTX1	0.807070645	3.13E-29
THYM	Cell metabolism gene	EIF4EBP1	ITPA	0.80828986	2.22E-29
THYM	Cell metabolism gene	EIF4EBP1	NANS	0.809060111	1.79E-29
THYM	Cell metabolism gene	EIF4EBP1	GEMIN7	0.810501911	1.19E-29
THYM	Cell metabolism gene	EIF4EBP1	EXOSC5	0.810652803	1.14E-29
THYM	Cell metabolism gene	EIF4EBP1	PSMB3	0.813259383	5.39E-30
THYM	Cell metabolism gene	EIF4EBP1	TIMM13	0.813542642	4.96E-30
THYM	Cell metabolism gene	EIF4EBP1	SNRPD2	0.813567369	4.93E-30
THYM	Cell metabolism gene	EIF4EBP1	TIMM10	0.821233516	5.06E-31
THYM	Cell metabolism gene	EIF4EBP1	TBCB	0.824733015	1.73E-31
THYM	Cell metabolism gene	EIF4EBP1	NME1	0.82549921	1.36E-31
THYM	Cell metabolism gene	EIF4EBP1	SRM	0.829442131	3.91E-32
THYM	Cell metabolism gene	EIF4EBP1	DOHH	0.832123705	1.65E-32
THYM	Cell metabolism gene	EIF4EBP1	HMBS	0.832143212	1.64E-32
THYM	Cell metabolism gene	EIF4EBP1	NME2	0.835169553	6.04E-33
THYM	Cell metabolism gene	EIF4EBP1	TIMM8B	0.839153748	1.58E-33
THYM	Cell metabolism gene	EIF4EBP1	EXOSC4	0.841169533	7.88E-34
THYM	Cell metabolism gene	EIF4EBP1	GMPPA	0.848756903	5.30E-35
THYM	Cell metabolism gene	EIF4EBP1	TIMM50	0.850649987	2.64E-35
THYM	Cell metabolism gene	EIF4EBP1	POLR2H	0.874248455	1.82E-39
THYM	Cell metabolism gene	EIF4EBP1	ALG3	0.874698186	1.49E-39
THYM	Epifactor	EIF4EBP1	BRMS1	0.804532572	6.31E-29
THYM	Epifactor	EIF4EBP1	EXOSC5	0.810652803	1.14E-29
THYM	Epifactor	EIF4EBP1	FBL	0.824149077	2.07E-31
THYM	Epifactor	EIF4EBP1	PRMT1	0.824233403	2.02E-31
THYM	Epifactor	EIF4EBP1	SIRT6	0.834970193	6.45E-33
THYM	Epifactor	EIF4EBP1	EXOSC4	0.841169533	7.88E-34
THYM	IUPHAR	EIF4EBP1	SLC27A5	0.803290122	8.87E-29
THYM	IUPHAR	EIF4EBP1	ECE2	0.804955333	5.62E-29
THYM	IUPHAR	EIF4EBP1	SLC39A4	0.816223004	2.27E-30
THYM	IUPHAR	EIF4EBP1	FKBP1A	0.82422907	2.02E-31
THYM	IUPHAR	EIF4EBP1	PRMT1	0.824233403	2.02E-31
THYM	IUPHAR	EIF4EBP1	SIRT6	0.834970193	6.45E-33
THYM	TF	EIF4EBP1	ZNF787	0.807555978	2.73E-29
THYM	TF	EIF4EBP1	ZNF511	0.812742428	6.25E-30
THYM	TF	EIF4EBP1	NME2	0.835169553	6.04E-33
THYM	TSG	EIF4EBP1	BRMS1	0.804532572	6.31E-29
THYM	TSG	EIF4EBP1	SLC39A4	0.816223004	2.27E-30
THYM	TSG	EIF4EBP1	GADD45GIP1	0.821301189	4.96E-31
THYM	TSG	EIF4EBP1	PYCARD	0.822713552	3.22E-31
THYM	TSG	EIF4EBP1	NME1	0.82549921	1.36E-31
THYM	TSG	EIF4EBP1	SIRT6	0.834970193	6.45E-33
UCS	Cell metabolism gene	EIF4EBP1	PMM2	0.802998013	9.61E-29
UCS	Cell metabolism gene	EIF4EBP1	SLC27A5	0.803290122	8.87E-29
UCS	Cell metabolism gene	EIF4EBP1	TOMM40	0.805071358	5.44E-29
UCS	Cell metabolism gene	EIF4EBP1	TSTA3	0.805341062	5.05E-29
UCS	Cell metabolism gene	EIF4EBP1	MTX1	0.807070645	3.13E-29
UCS	Cell metabolism gene	EIF4EBP1	ITPA	0.80828986	2.22E-29
UCS	Cell metabolism gene	EIF4EBP1	NANS	0.809060111	1.79E-29
UCS	Cell metabolism gene	EIF4EBP1	GEMIN7	0.810501911	1.19E-29
UCS	Cell metabolism gene	EIF4EBP1	EXOSC5	0.810652803	1.14E-29
UCS	Cell metabolism gene	EIF4EBP1	PSMB3	0.813259383	5.39E-30
UCS	Cell metabolism gene	EIF4EBP1	TIMM13	0.813542642	4.96E-30
UCS	Cell metabolism gene	EIF4EBP1	SNRPD2	0.813567369	4.93E-30
UCS	Cell metabolism gene	EIF4EBP1	TIMM10	0.821233516	5.06E-31
UCS	Cell metabolism gene	EIF4EBP1	TBCB	0.824733015	1.73E-31
UCS	Cell metabolism gene	EIF4EBP1	NME1	0.82549921	1.36E-31
UCS	Cell metabolism gene	EIF4EBP1	SRM	0.829442131	3.91E-32
UCS	Cell metabolism gene	EIF4EBP1	DOHH	0.832123705	1.65E-32
UCS	Cell metabolism gene	EIF4EBP1	HMBS	0.832143212	1.64E-32
UCS	Cell metabolism gene	EIF4EBP1	NME2	0.835169553	6.04E-33
UCS	Cell metabolism gene	EIF4EBP1	TIMM8B	0.839153748	1.58E-33
UCS	Cell metabolism gene	EIF4EBP1	EXOSC4	0.841169533	7.88E-34
UCS	Cell metabolism gene	EIF4EBP1	GMPPA	0.848756903	5.30E-35
UCS	Cell metabolism gene	EIF4EBP1	TIMM50	0.850649987	2.64E-35
UCS	Cell metabolism gene	EIF4EBP1	POLR2H	0.874248455	1.82E-39
UCS	Cell metabolism gene	EIF4EBP1	ALG3	0.874698186	1.49E-39
UCS	Epifactor	EIF4EBP1	BRMS1	0.804532572	6.31E-29
UCS	Epifactor	EIF4EBP1	EXOSC5	0.810652803	1.14E-29
UCS	Epifactor	EIF4EBP1	FBL	0.824149077	2.07E-31
UCS	Epifactor	EIF4EBP1	PRMT1	0.824233403	2.02E-31
UCS	Epifactor	EIF4EBP1	SIRT6	0.834970193	6.45E-33
UCS	Epifactor	EIF4EBP1	EXOSC4	0.841169533	7.88E-34
UCS	IUPHAR	EIF4EBP1	SLC27A5	0.803290122	8.87E-29
UCS	IUPHAR	EIF4EBP1	ECE2	0.804955333	5.62E-29
UCS	IUPHAR	EIF4EBP1	SLC39A4	0.816223004	2.27E-30
UCS	IUPHAR	EIF4EBP1	FKBP1A	0.82422907	2.02E-31
UCS	IUPHAR	EIF4EBP1	PRMT1	0.824233403	2.02E-31
UCS	IUPHAR	EIF4EBP1	SIRT6	0.834970193	6.45E-33
UCS	TF	EIF4EBP1	ZNF787	0.807555978	2.73E-29
UCS	TF	EIF4EBP1	ZNF511	0.812742428	6.25E-30
UCS	TF	EIF4EBP1	NME2	0.835169553	6.04E-33
UCS	TSG	EIF4EBP1	BRMS1	0.804532572	6.31E-29
UCS	TSG	EIF4EBP1	SLC39A4	0.816223004	2.27E-30
UCS	TSG	EIF4EBP1	GADD45GIP1	0.821301189	4.96E-31
UCS	TSG	EIF4EBP1	PYCARD	0.822713552	3.22E-31
UCS	TSG	EIF4EBP1	NME1	0.82549921	1.36E-31
UCS	TSG	EIF4EBP1	SIRT6	0.834970193	6.45E-33
UVM	Cell metabolism gene	EIF4EBP1	SLC25A1	0.800100445	5.45E-19
UVM	Epifactor	EIF4EBP1	RUVBL2	0.804732664	2.40E-19
UVM	Epifactor	EIF4EBP1	PELP1	0.826329817	3.85E-21
UVM	Epifactor	EIF4EBP1	C17orf49	0.830100735	1.77E-21
UVM	IUPHAR	EIF4EBP1	SLC25A1	0.800100445	5.45E-19
UVM	IUPHAR	EIF4EBP1	SLC25A39	0.803543456	2.97E-19
UVM	IUPHAR	EIF4EBP1	SCYL1	0.811115398	7.49E-20
UVM	Kinase	EIF4EBP1	SCYL1	0.811115398	7.49E-20
UVM	TSG	EIF4EBP1	SCYL1	0.811115398	7.49E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	EIF4EBP1	EIF4E2	-1.6767866186069	0.000144809484481812
BRCA	EIF4EBP1	EIF4E2	-1.81299600715269	0.000370278590179521
LUAD	EIF4EBP1	EIF4E2	-1.75169025615215	0.000823732994424591
THCA	EIF4EBP1	FKBP1A	-2.88688228811274	0.00088455514534471
BRCA	EIF4EBP1	RHEB	-1.34423616302394	0.00103883851257192
CHOL	EIF4EBP1	RPTOR	-2.34317187916664	0.00390625
KICH	EIF4EBP1	EIF4G1	-1.46656081150743	0.00612920522689819
BLCA	EIF4EBP1	FKBP1A	-2.74500958748462	0.0061798095703125
KICH	EIF4EBP1	RHEB	1.83191315229171	0.0236499309539795
LUAD	EIF4EBP1	AKT1	-4.53714460696341	0.0301695351050489
LUAD	EIF4EBP1	MLST8	-1.0067433555627	1.03207777888518e-06
KIRC	EIF4EBP1	EIF4E2	-4.19473040895577	1.04336657477644e-05
BRCA	EIF4EBP1	MLST8	-1.86304443127359	1.06372586581501e-16
BRCA	EIF4EBP1	AKT1S1	-1.36773925418723	1.24224675305145e-11
LUSC	EIF4EBP1	MLST8	-2.07059311474544	3.67421243367441e-07
LIHC	EIF4EBP1	AKT1S1	1.82771941001661	4.2584580238307e-05
LIHC	EIF4EBP1	FKBP1A	-1.09181838113595	4.43935944712054e-05
PRAD	EIF4EBP1	RHEB	1.54870835586921	4.59461327401057e-05
KICH	EIF4EBP1	EIF4E	1.61675210562671	6.55651092529297e-06
LIHC	EIF4EBP1	RPTOR	-4.36362270436135	6.64579404273587e-07
PRAD	EIF4EBP1	MTOR	2.45767376269894	8.16442831201447e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF4EBP1

CHTF8, EIF4E, UBAC1, ATM, MTOR, LRPAP1, PPP2R2A, Mtor, RPTOR, MEC1, GSK3B, IRAK4, PRKCA, KLHL25, MAPK1, AGO2, LRRK2, MAPK14, STK3, PPP2R4, PRKDC, LATS1, SLMAP, MLST8, REL, TCF4, AKT2, AKT3, CCDC94, CHMP2A, DDX1, FLNB, GGA1, HNRNPA1, SHMT2, HNRNPAB, AKT1, BUB1, MAPKAPK5, TRIM25, TRIM14, TOR1, RICTOR, MEOX1, PICK1, POU6F2, LMO2, EIF4E2, DDIT4L, EIF4E1B, ZNF655, EIF4G1, EIF4EBP2, EIF4ENIF1, EIF4G3, EIF4A2, EIF3B, EIF3D, EIF3C, EIF3L, EIF3I, EIF3K, EIF3H, EIF3G, EIF3A, EIF3M, EIF3E, ANGEL1, RPS27L, EIF3F, CRMP1, FBXO11, CARM1, PCBP3, BTBD1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF4EBP1	chr8	37914738	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF4EBP1	SKCM	chr8	37914620	37914620	G	A	Missense_Mutation	p.R56Q	4
EIF4EBP1	HNSC	chr8	37914654	37914654	G	T	Silent	p.V67V	3
EIF4EBP1	SKCM	chr8	37914672	37914672	G	A	Silent	p.R73R	2
EIF4EBP1	ESCA	chr8	37914778	37914778	G	A	Missense_Mutation	p.G109S	2
EIF4EBP1	ESCA	chr8	37914778	37914778	G	A	Missense_Mutation		2
EIF4EBP1	STAD	chr8	37914620	37914620	G	A	Missense_Mutation		2
EIF4EBP1	ESCA	chr8	37914778	37914778	G	A	Splice_Site	p.G109_splice	2
EIF4EBP1	STAD	chr8	37914619	37914619	C	T	Missense_Mutation	p.R56W	2
EIF4EBP1	KIRP	chr8	37914666	37914666	C	A	Silent		2
EIF4EBP1	BLCA	chr8	37914710	37914710	G	A	Missense_Mutation	p.S86N	2
EIF4EBP1	HNSC	chr8	37914654	37914654	G	T	Silent		1
EIF4EBP1	STAD	chr8	37914773	37914773	C	T	Missense_Mutation	p.A107V	1
EIF4EBP1	HNSC	chr8	37914778	37914778	G	T	Missense_Mutation	p.G109C	1
EIF4EBP1	LIHC	chr8	37914651	37914651	T	C	Silent		1
EIF4EBP1	LIHC	chr8	37914726	37914726	G	-	Frame_Shift_Del		1
EIF4EBP1	BLCA	chr8	37914710	37914710	G	A	Missense_Mutation		1
EIF4EBP1	LUSC	chr8	37914609	37914609	C	T	Silent	p.I52I	1

Copy number variation (CNV) of EIF4EBP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF4EBP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102758	LIHC	TCGA-KR-A7K8-01A	ASPH	chr8	62430087	-	EIF4EBP1	chr8	37914599	+
102758	N/A	BF437073	BAZ1B	chr7	72866832	+	EIF4EBP1	chr8	37914456	-
102758	SARC	TCGA-DX-A3LS	C12orf65	chr12	123718078	+	EIF4EBP1	chr8	37914598	+
102758	SARC	TCGA-DX-A3LS-01A	C12orf65	chr12	123718078	+	EIF4EBP1	chr8	37914599	+
102758	LUSC	TCGA-85-8070-01A	DDHD2	chr8	38111236	+	EIF4EBP1	chr8	37914599	+
81064	BRCA	TCGA-C8-A1HN-01A	EIF4EBP1	chr8	37888236	+	ADAM12	chr10	127734701	-
99193	SARC	TCGA-LI-A67I-01A	EIF4EBP1	chr8	37888236	+	ADAM18	chr8	39564309	+
99205	LIHC	TCGA-XR-A8TG-01A	EIF4EBP1	chr8	37914778	+	GPR124	chr8	37672414	+
89687	BRCA	TCGA-E2-A106-01A	EIF4EBP1	chr8	37888236	+	POLR1D	chr13	28312844	+
99221	HNSC	TCGA-CR-7364-01A	EIF4EBP1	chr8	37888236	+	TACC1	chr8	38704217	+
71465	N/A	BG576403	EIF4EBP1	chr8	37917883	+	ZNF705D	chr8	11949437	-
102758	BRCA	TCGA-S3-AA12	GTF2E2	chr8	30510949	-	EIF4EBP1	chr8	37914598	+
102758	BRCA	TCGA-S3-AA12-01A	GTF2E2	chr8	30510950	-	EIF4EBP1	chr8	37914599	+
102758	LUSC	TCGA-43-2576	HS6ST3	chr13	96743823	+	EIF4EBP1	chr8	37914598	+
102758	LUSC	TCGA-43-2576-01A	HS6ST3	chr13	96743823	+	EIF4EBP1	chr8	37914599	+
102758	BRCA	TCGA-A7-A0D9-01A	LRRC28	chr15	99901716	+	EIF4EBP1	chr8	37914599	+
102758	PRAD	TCGA-FC-A4JI	NCOA2	chr8	71315934	-	EIF4EBP1	chr8	37914598	+
102758	PRAD	TCGA-FC-A4JI-01A	NCOA2	chr8	71315935	-	EIF4EBP1	chr8	37914599	+
102758	BRCA	TCGA-AO-A0JI	PPP2R5C	chr14	102252520	+	EIF4EBP1	chr8	37914598	+
102758	N/A	AX185526	RP11-567N4.2	chr4	76324594	-	EIF4EBP1	chr8	37890283	-
102758	STAD	TCGA-CD-8530-01A	RPL7A	chr9	136215897	+	EIF4EBP1	chr8	37914599	+
102758	N/A	BG575369	RSL1D1	chr16	11931212	-	EIF4EBP1	chr8	37894893	-
102758	STAD	TCGA-CD-A486-01A	TPTEP1	chr22	17083105	+	EIF4EBP1	chr8	37914599	+
102758	PRAD	TCGA-J9-A8CP-01A	UNC5D	chr8	35093405	-	EIF4EBP1	chr8	37914599	+
102758	BRCA	TCGA-AR-A5QQ	ZNF703	chr8	37553740	+	EIF4EBP1	chr8	37914598	+
102758	BRCA	TCGA-AR-A5QQ-01A	ZNF703	chr8	37553739	+	EIF4EBP1	chr8	37914598	+
102758	BRCA	TCGA-AR-A5QQ-01A	ZNF703	chr8	37553740	+	EIF4EBP1	chr8	37914599	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	EIF4EBP1	0.000754324471258832	0.021

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF4EBP1	3.41549495983401e-05	0.0011
SARC	EIF4EBP1	0.000193984789628357	0.0062

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0022665	Kidney Neoplasm	1	CTD_human
C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
C0282313	Condition, Preneoplastic	1	CTD_human
C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	1	CTD_human
C0740457	Malignant neoplasm of kidney	1	CTD_human
C0751958	Lymphoma, Lymphocytic, Intermediate	1	CTD_human
C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
C4505456	HIV Coinfection	1	CTD_human