Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CPEB3 (NCBI Gene ID:22849)

Gene Summary

Gene Summary

Gene Information	Gene Name: CPEB3
	Gene ID: 22849
	Gene Symbol	CPEB3
	Gene ID	22849
	Gene Name	cytoplasmic polyadenylation element binding protein 3
	Synonyms	-
	Cytomap	10q23.32
	Type of Gene	protein-coding
	Description	cytoplasmic polyadenylation element-binding protein 3CPE-BP3CPE-binding protein 3hCPEB-3
	Modification date	20200322
	UniProtAcc	Q8NE35

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0045727	Positive regulation of translation
GO:0006414	Translational elongation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CPEB3	GO:0000122	negative regulation of transcription by RNA polymerase II	20639532
Hgene	CPEB3	GO:0017148	negative regulation of translation	21336257\|22711986
Hgene	CPEB3	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21336257
Hgene	CPEB3	GO:0061158	3'-UTR-mediated mRNA destabilization	21336257
Hgene	CPEB3	GO:0071230	cellular response to amino acid stimulus	20639532\|22730302
Hgene	CPEB3	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21336257

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CPEB3	(733 - 1119.25]

Top

Translation Studies in PubMed

We searched PubMed using 'CPEB3[title] AND translation [title] AND human.'

Gene	Title	PMID
CPEB3	PEB3-dowregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice	33941859

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000265997	93851586	93851701	Frame-shift
ENST00000265997	93902785	93902875	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000265997	93902785	93902875	4868	1537	1626	698	454	484

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	CPEB3	-2.62322690566665	0.0009765625
THCA	CPEB3	-2.13966947208296	1.4511333759112e-09
KIRP	CPEB3	-2.10404966038944	2.00234353542328e-08
STAD	CPEB3	-1.54185853666543	4.89074736833573e-05
KIRC	CPEB3	-2.21721784201043	9.27353127921009e-13
BRCA	CPEB3	-1.73007606795991	9.80448817083816e-10
LIHC	CPEB3	-2.05610354356704	9.93036701162759e-10

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
TGCT	CPEB3	2	1	0.034408947465652	0.22651887755102	0.149922663551402	1.91591645584212	1.59815486896454

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
CESC	CPEB3	2	1	0.0109727944242387	0.250724041811847	0.13898701863354	-1.14804506323289	-0.649869612544063
MESO	CPEB3	2	1	0.0499025992436606	0.249465	0.132282291666667	-0.17133758355802	0.963065471997425

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with CPEB3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	CPEB3	DAO	0.800756107	4.01E-11
CHOL	Cell metabolism gene	CPEB3	HIBCH	0.801118249	3.87E-11
CHOL	Cell metabolism gene	CPEB3	CES2	0.801675548	3.67E-11
CHOL	Cell metabolism gene	CPEB3	LDHD	0.80215826	3.50E-11
CHOL	Cell metabolism gene	CPEB3	PIGV	0.802682994	3.32E-11
CHOL	Cell metabolism gene	CPEB3	GLUD1	0.802701255	3.31E-11
CHOL	Cell metabolism gene	CPEB3	SLC10A1	0.803721272	3.00E-11
CHOL	Cell metabolism gene	CPEB3	DGAT2	0.804207279	2.86E-11
CHOL	Cell metabolism gene	CPEB3	CNDP1	0.80424684	2.85E-11
CHOL	Cell metabolism gene	CPEB3	QDPR	0.804432923	2.79E-11
CHOL	Cell metabolism gene	CPEB3	SAR1B	0.804603921	2.75E-11
CHOL	Cell metabolism gene	CPEB3	ACACB	0.804865355	2.68E-11
CHOL	Cell metabolism gene	CPEB3	GOT2	0.805312451	2.56E-11
CHOL	Cell metabolism gene	CPEB3	PLIN1	0.805593577	2.49E-11
CHOL	Cell metabolism gene	CPEB3	LONP2	0.806079526	2.37E-11
CHOL	Cell metabolism gene	CPEB3	HAL	0.806601173	2.25E-11
CHOL	Cell metabolism gene	CPEB3	UPB1	0.80689218	2.19E-11
CHOL	Cell metabolism gene	CPEB3	ALAD	0.807636495	2.03E-11
CHOL	Cell metabolism gene	CPEB3	ACADL	0.808296093	1.90E-11
CHOL	Cell metabolism gene	CPEB3	GLS2	0.808428952	1.87E-11
CHOL	Cell metabolism gene	CPEB3	MOCS2	0.808888945	1.79E-11
CHOL	Cell metabolism gene	CPEB3	CTH	0.809162176	1.74E-11
CHOL	Cell metabolism gene	CPEB3	PLA2G12B	0.809775088	1.63E-11
CHOL	Cell metabolism gene	CPEB3	ALDH9A1	0.809884927	1.61E-11
CHOL	Cell metabolism gene	CPEB3	ACAA1	0.810188665	1.56E-11
CHOL	Cell metabolism gene	CPEB3	PROS1	0.810973976	1.44E-11
CHOL	Cell metabolism gene	CPEB3	ABCA1	0.812053634	1.29E-11
CHOL	Cell metabolism gene	CPEB3	ASPA	0.812859433	1.19E-11
CHOL	Cell metabolism gene	CPEB3	HIBADH	0.817174067	7.53E-12
CHOL	Cell metabolism gene	CPEB3	HADH	0.817380758	7.36E-12
CHOL	Cell metabolism gene	CPEB3	SCP2	0.817755198	7.07E-12
CHOL	Cell metabolism gene	CPEB3	INHBC	0.817855629	7.00E-12
CHOL	Cell metabolism gene	CPEB3	PIK3R1	0.817971053	6.91E-12
CHOL	Cell metabolism gene	CPEB3	PDHB	0.818623333	6.44E-12
CHOL	Cell metabolism gene	CPEB3	ABCG2	0.818765837	6.34E-12
CHOL	Cell metabolism gene	CPEB3	PIPOX	0.818878075	6.27E-12
CHOL	Cell metabolism gene	CPEB3	ST3GAL6	0.819008168	6.18E-12
CHOL	Cell metabolism gene	CPEB3	GLUD2	0.819037371	6.16E-12
CHOL	Cell metabolism gene	CPEB3	MTHFD1	0.819161686	6.08E-12
CHOL	Cell metabolism gene	CPEB3	PANK1	0.821790867	4.56E-12
CHOL	Cell metabolism gene	CPEB3	TDO2	0.822595491	4.17E-12
CHOL	Cell metabolism gene	CPEB3	ACADM	0.822690888	4.13E-12
CHOL	Cell metabolism gene	CPEB3	FBP1	0.822706169	4.12E-12
CHOL	Cell metabolism gene	CPEB3	ADI1	0.823573463	3.75E-12
CHOL	Cell metabolism gene	CPEB3	DBH	0.824629543	3.33E-12
CHOL	Cell metabolism gene	CPEB3	MLYCD	0.824741156	3.29E-12
CHOL	Cell metabolism gene	CPEB3	SLC25A13	0.825663111	2.96E-12
CHOL	Cell metabolism gene	CPEB3	SUCLG2	0.825755356	2.93E-12
CHOL	Cell metabolism gene	CPEB3	GPHN	0.827871669	2.31E-12
CHOL	Cell metabolism gene	CPEB3	AGL	0.828895435	2.05E-12
CHOL	Cell metabolism gene	CPEB3	AASS	0.829211368	1.98E-12
CHOL	Cell metabolism gene	CPEB3	SLC25A15	0.832842202	1.30E-12
CHOL	Cell metabolism gene	CPEB3	LPA	0.832965383	1.28E-12
CHOL	Cell metabolism gene	CPEB3	MTM1	0.833966527	1.13E-12
CHOL	Cell metabolism gene	CPEB3	PPARA	0.83595359	8.94E-13
CHOL	Cell metabolism gene	CPEB3	SARDH	0.838747773	6.36E-13
CHOL	Cell metabolism gene	CPEB3	IDI1	0.839463404	5.83E-13
CHOL	Cell metabolism gene	CPEB3	PI4K2B	0.839572395	5.75E-13
CHOL	Cell metabolism gene	CPEB3	EHHADH	0.840600738	5.06E-13
CHOL	Cell metabolism gene	CPEB3	PHYH	0.845531958	2.71E-13
CHOL	Cell metabolism gene	CPEB3	ACOX2	0.845774151	2.63E-13
CHOL	Cell metabolism gene	CPEB3	ALAS1	0.845824373	2.61E-13
CHOL	Cell metabolism gene	CPEB3	MCEE	0.847817962	2.02E-13
CHOL	Cell metabolism gene	CPEB3	ALDH5A1	0.851948843	1.17E-13
CHOL	Cell metabolism gene	CPEB3	BCKDHB	0.852563571	1.07E-13
CHOL	Cell metabolism gene	CPEB3	A2M	0.856465176	6.28E-14
CHOL	Cell metabolism gene	CPEB3	ENPP1	0.85749228	5.44E-14
CHOL	Cell metabolism gene	CPEB3	GNMT	0.858098822	4.99E-14
CHOL	Cell metabolism gene	CPEB3	MUT	0.858358973	4.81E-14
CHOL	Cell metabolism gene	CPEB3	PCK2	0.858970483	4.41E-14
CHOL	Cell metabolism gene	CPEB3	SLC25A20	0.859284969	4.22E-14
CHOL	Cell metabolism gene	CPEB3	RAPGEF4	0.85934909	4.18E-14
CHOL	Cell metabolism gene	CPEB3	ACSM5	0.861837261	2.92E-14
CHOL	Cell metabolism gene	CPEB3	ACSL1	0.869628192	9.11E-15
CHOL	Cell metabolism gene	CPEB3	ABCB11	0.871507034	6.80E-15
CHOL	Cell metabolism gene	CPEB3	CAT	0.874031595	4.56E-15
CHOL	Cell metabolism gene	CPEB3	HSD17B4	0.889533692	3.18E-16
CHOL	Cell metabolism gene	CPEB3	ALDH6A1	0.89800175	6.24E-17
CHOL	Cell metabolism gene	CPEB3	ABAT	0.89820909	5.99E-17
CHOL	Cell metabolism gene	CPEB3	ACADSB	0.903616603	1.96E-17
CHOL	CGC	CPEB3	ESR1	0.802299872	3.45E-11
CHOL	CGC	CPEB3	NCOA4	0.812297426	1.26E-11
CHOL	CGC	CPEB3	PIK3R1	0.817971053	6.91E-12
CHOL	CGC	CPEB3	GPHN	0.827871669	2.31E-12
CHOL	Epifactor	CPEB3	KAT2B	0.823378024	3.83E-12
CHOL	Epifactor	CPEB3	CECR2	0.888915248	3.56E-16
CHOL	IUPHAR	CPEB3	ESR1	0.802299872	3.45E-11
CHOL	IUPHAR	CPEB3	SLC10A1	0.803721272	3.00E-11
CHOL	IUPHAR	CPEB3	CNDP1	0.80424684	2.85E-11
CHOL	IUPHAR	CPEB3	SLC35D1	0.804432394	2.79E-11
CHOL	IUPHAR	CPEB3	ACACB	0.804865355	2.68E-11
CHOL	IUPHAR	CPEB3	CHRNA4	0.805300201	2.56E-11
CHOL	IUPHAR	CPEB3	NR1I3	0.807876696	1.98E-11
CHOL	IUPHAR	CPEB3	CNTFR	0.808075462	1.94E-11
CHOL	IUPHAR	CPEB3	SIGMAR1	0.808869514	1.79E-11
CHOL	IUPHAR	CPEB3	CTH	0.809162176	1.74E-11
CHOL	IUPHAR	CPEB3	ALDH9A1	0.809884927	1.61E-11
CHOL	IUPHAR	CPEB3	ABCA8	0.810280176	1.55E-11
CHOL	IUPHAR	CPEB3	SGK3	0.810709314	1.48E-11
CHOL	IUPHAR	CPEB3	ABHD6	0.810879739	1.46E-11
CHOL	IUPHAR	CPEB3	SLC7A2	0.81135029	1.39E-11
CHOL	IUPHAR	CPEB3	AQP9	0.811764146	1.33E-11
CHOL	IUPHAR	CPEB3	CYP3A43	0.812000399	1.30E-11
CHOL	IUPHAR	CPEB3	ABCA1	0.812053634	1.29E-11
CHOL	IUPHAR	CPEB3	FOLH1B	0.815996331	8.53E-12
CHOL	IUPHAR	CPEB3	SLC25A42	0.816015623	8.51E-12
CHOL	IUPHAR	CPEB3	NLRP14	0.816667372	7.94E-12
CHOL	IUPHAR	CPEB3	PIK3R1	0.817971053	6.91E-12
CHOL	IUPHAR	CPEB3	ABCG2	0.818765837	6.34E-12
CHOL	IUPHAR	CPEB3	MOGAT2	0.820699526	5.14E-12
CHOL	IUPHAR	CPEB3	SLC6A1	0.820968303	4.99E-12
CHOL	IUPHAR	CPEB3	SLC31A1	0.821996645	4.46E-12
CHOL	IUPHAR	CPEB3	TDO2	0.822595491	4.17E-12
CHOL	IUPHAR	CPEB3	SLC6A13	0.822739352	4.11E-12
CHOL	IUPHAR	CPEB3	KAT2B	0.823378024	3.83E-12
CHOL	IUPHAR	CPEB3	DBH	0.824629543	3.33E-12
CHOL	IUPHAR	CPEB3	MLYCD	0.824741156	3.29E-12
CHOL	IUPHAR	CPEB3	SLC25A13	0.825663111	2.96E-12
CHOL	IUPHAR	CPEB3	GPR88	0.829085801	2.01E-12
CHOL	IUPHAR	CPEB3	SLC22A25	0.831853696	1.46E-12
CHOL	IUPHAR	CPEB3	SLC25A15	0.832842202	1.30E-12
CHOL	IUPHAR	CPEB3	PPARA	0.83595359	8.94E-13
CHOL	IUPHAR	CPEB3	SLC6A12	0.836228335	8.65E-13
CHOL	IUPHAR	CPEB3	ADRA1A	0.837154709	7.73E-13
CHOL	IUPHAR	CPEB3	SFXN1	0.83814731	6.85E-13
CHOL	IUPHAR	CPEB3	IDI1	0.839463404	5.83E-13
CHOL	IUPHAR	CPEB3	PI4K2B	0.839572395	5.75E-13
CHOL	IUPHAR	CPEB3	ALDH5A1	0.851948843	1.17E-13
CHOL	IUPHAR	CPEB3	ABCA6	0.856816844	5.98E-14
CHOL	IUPHAR	CPEB3	SLC25A20	0.859284969	4.22E-14
CHOL	IUPHAR	CPEB3	RAPGEF4	0.85934909	4.18E-14
CHOL	IUPHAR	CPEB3	WNK3	0.863290783	2.37E-14
CHOL	IUPHAR	CPEB3	ABCB11	0.871507034	6.80E-15
CHOL	IUPHAR	CPEB3	CAT	0.874031595	4.56E-15
CHOL	IUPHAR	CPEB3	ENPEP	0.875747048	3.45E-15
CHOL	IUPHAR	CPEB3	LEPR	0.885289507	6.84E-16
CHOL	IUPHAR	CPEB3	CECR2	0.888915248	3.56E-16
CHOL	IUPHAR	CPEB3	ABAT	0.89820909	5.99E-17
CHOL	Kinase	CPEB3	SGK3	0.810709314	1.48E-11
CHOL	Kinase	CPEB3	WNK3	0.863290783	2.37E-14
CHOL	TF	CPEB3	ESR1	0.802299872	3.45E-11
CHOL	TF	CPEB3	NR1I3	0.807876696	1.98E-11
CHOL	TF	CPEB3	PEG3	0.817620979	7.17E-12
CHOL	TF	CPEB3	PPARA	0.83595359	8.94E-13
CHOL	TF	CPEB3	SOX5	0.844109843	3.25E-13
CHOL	TF	CPEB3	ARID3C	0.883454471	9.44E-16
CHOL	TSG	CPEB3	ESR1	0.802299872	3.45E-11
CHOL	TSG	CPEB3	GLS2	0.808428952	1.87E-11
CHOL	TSG	CPEB3	NCOA4	0.812297426	1.26E-11
CHOL	TSG	CPEB3	CTNNA3	0.817053243	7.62E-12
CHOL	TSG	CPEB3	PEG3	0.817620979	7.17E-12
CHOL	TSG	CPEB3	ABCG2	0.818765837	6.34E-12
CHOL	TSG	CPEB3	FBP1	0.822706169	4.12E-12
CHOL	TSG	CPEB3	PPARA	0.83595359	8.94E-13
CHOL	TSG	CPEB3	GNMT	0.858098822	4.99E-14
CHOL	TSG	CPEB3	CAT	0.874031595	4.56E-15
TGCT	Cell metabolism gene	CPEB3	MTMR3	0.807030802	4.66E-37
TGCT	Epifactor	CPEB3	RPS6KA5	0.809580443	1.86E-37
TGCT	Epifactor	CPEB3	ERCC6	0.814253975	3.33E-38
TGCT	Epifactor	CPEB3	BMI1	0.832621036	2.33E-41
TGCT	IUPHAR	CPEB3	TRPM7	0.804874194	1.00E-36
TGCT	IUPHAR	CPEB3	RPS6KA5	0.809580443	1.86E-37
TGCT	IUPHAR	CPEB3	NLRP14	0.818033743	7.98E-39
TGCT	IUPHAR	CPEB3	SLC12A6	0.87675659	8.03E-51
TGCT	Kinase	CPEB3	TRPM7	0.804874194	1.00E-36
TGCT	Kinase	CPEB3	RPS6KA5	0.809580443	1.86E-37
TGCT	TF	CPEB3	ZNF304	0.814471896	3.07E-38
TGCT	TF	CPEB3	ZNF654	0.841096675	6.02E-43
TGCT	TF	CPEB3	ZBTB43	0.842473728	3.26E-43
TGCT	TSG	CPEB3	SMCHD1	0.82897557	1.05E-40
THCA	Cell metabolism gene	CPEB3	SACM1L	0.802386679	6.97E-130
THCA	Cell metabolism gene	CPEB3	ACADSB	0.821750771	2.46E-141
THYM	Cell metabolism gene	CPEB3	YAP1	0.814739871	3.50E-30
THYM	Cell metabolism gene	CPEB3	PIK3C2A	0.828872115	4.69E-32
THYM	Cell metabolism gene	CPEB3	SGMS1	0.838866096	1.74E-33
THYM	CGC	CPEB3	TET2	0.800327318	1.98E-28
THYM	CGC	CPEB3	ARHGEF12	0.808796821	1.93E-29
THYM	CGC	CPEB3	ARHGAP5	0.823537765	2.50E-31
THYM	Epifactor	CPEB3	TET2	0.800327318	1.98E-28
THYM	Epifactor	CPEB3	DZIP3	0.806775054	3.40E-29
THYM	Epifactor	CPEB3	ZMYND11	0.80993218	1.40E-29
THYM	IUPHAR	CPEB3	PREPL	0.803793986	7.73E-29
THYM	IUPHAR	CPEB3	ZMYND11	0.80993218	1.40E-29
THYM	IUPHAR	CPEB3	PKN2	0.812738486	6.26E-30
THYM	IUPHAR	CPEB3	MAP4K3	0.813045445	5.73E-30
THYM	IUPHAR	CPEB3	SLC35F5	0.828586343	5.14E-32
THYM	IUPHAR	CPEB3	PIK3C2A	0.828872115	4.69E-32
THYM	IUPHAR	CPEB3	SGMS1	0.838866096	1.74E-33
THYM	Kinase	CPEB3	PKN2	0.812738486	6.26E-30
THYM	Kinase	CPEB3	MAP4K3	0.813045445	5.73E-30
THYM	TF	CPEB3	TET2	0.800327318	1.98E-28
THYM	TF	CPEB3	ZNF25	0.801564547	1.42E-28
THYM	TF	CPEB3	BBX	0.802135369	1.22E-28
THYM	TF	CPEB3	ZBTB38	0.804899098	5.71E-29
THYM	TF	CPEB3	NFAT5	0.805685108	4.59E-29
THYM	TF	CPEB3	ZNF471	0.821599615	4.53E-31
THYM	TSG	CPEB3	TET2	0.800327318	1.98E-28
THYM	TSG	CPEB3	ARHGEF12	0.808796821	1.93E-29
THYM	TSG	CPEB3	ZMYND11	0.80993218	1.40E-29
THYM	TSG	CPEB3	YAP1	0.814739871	3.50E-30
THYM	TSG	CPEB3	SGMS1	0.838866096	1.74E-33
UCS	Cell metabolism gene	CPEB3	YAP1	0.814739871	3.50E-30
UCS	Cell metabolism gene	CPEB3	PIK3C2A	0.828872115	4.69E-32
UCS	Cell metabolism gene	CPEB3	SGMS1	0.838866096	1.74E-33
UCS	CGC	CPEB3	TET2	0.800327318	1.98E-28
UCS	CGC	CPEB3	ARHGEF12	0.808796821	1.93E-29
UCS	CGC	CPEB3	ARHGAP5	0.823537765	2.50E-31
UCS	Epifactor	CPEB3	TET2	0.800327318	1.98E-28
UCS	Epifactor	CPEB3	DZIP3	0.806775054	3.40E-29
UCS	Epifactor	CPEB3	ZMYND11	0.80993218	1.40E-29
UCS	IUPHAR	CPEB3	PREPL	0.803793986	7.73E-29
UCS	IUPHAR	CPEB3	ZMYND11	0.80993218	1.40E-29
UCS	IUPHAR	CPEB3	PKN2	0.812738486	6.26E-30
UCS	IUPHAR	CPEB3	MAP4K3	0.813045445	5.73E-30
UCS	IUPHAR	CPEB3	SLC35F5	0.828586343	5.14E-32
UCS	IUPHAR	CPEB3	PIK3C2A	0.828872115	4.69E-32
UCS	IUPHAR	CPEB3	SGMS1	0.838866096	1.74E-33
UCS	Kinase	CPEB3	PKN2	0.812738486	6.26E-30
UCS	Kinase	CPEB3	MAP4K3	0.813045445	5.73E-30
UCS	TF	CPEB3	TET2	0.800327318	1.98E-28
UCS	TF	CPEB3	ZNF25	0.801564547	1.42E-28
UCS	TF	CPEB3	BBX	0.802135369	1.22E-28
UCS	TF	CPEB3	ZBTB38	0.804899098	5.71E-29
UCS	TF	CPEB3	NFAT5	0.805685108	4.59E-29
UCS	TF	CPEB3	ZNF471	0.821599615	4.53E-31
UCS	TSG	CPEB3	TET2	0.800327318	1.98E-28
UCS	TSG	CPEB3	ARHGEF12	0.808796821	1.93E-29
UCS	TSG	CPEB3	ZMYND11	0.80993218	1.40E-29
UCS	TSG	CPEB3	YAP1	0.814739871	3.50E-30
UCS	TSG	CPEB3	SGMS1	0.838866096	1.74E-33
UVM	Cell metabolism gene	CPEB3	PIKFYVE	0.800598115	5.00E-19
UVM	Cell metabolism gene	CPEB3	GXYLT1	0.804118191	2.68E-19
UVM	Cell metabolism gene	CPEB3	RORA	0.807762351	1.39E-19
UVM	CGC	CPEB3	CYLD	0.804043578	2.72E-19
UVM	CGC	CPEB3	MALT1	0.80840874	1.23E-19
UVM	Epifactor	CPEB3	RMI1	0.802289687	3.71E-19
UVM	IUPHAR	CPEB3	PIKFYVE	0.800598115	5.00E-19
UVM	IUPHAR	CPEB3	XIAP	0.803543876	2.97E-19
UVM	IUPHAR	CPEB3	NR3C1	0.803870971	2.80E-19
UVM	IUPHAR	CPEB3	RORA	0.807762351	1.39E-19
UVM	IUPHAR	CPEB3	MALT1	0.80840874	1.23E-19
UVM	TF	CPEB3	NR3C1	0.803870971	2.80E-19
UVM	TF	CPEB3	RORA	0.807762351	1.39E-19
UVM	TSG	CPEB3	CYLD	0.804043578	2.72E-19
UVM	TSG	CPEB3	TANK	0.834770285	6.54E-22

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	CPEB3	CNOT6L	-3.87663737407518	0.000364991836249828
LUAD	CPEB3	CNOT6L	-2.1633182779043	0.00060389239279426
KIRP	CPEB3	CNOT2	-1.10448855710506	0.00222697434946895
CHOL	CPEB3	CNOT6	-4.83321533739418	0.00390625
CHOL	CPEB3	CNOT8	-1.86479733449004	0.00390625
KICH	CPEB3	CNOT3	-1.1461250404339	0.00882232189178467
CHOL	CPEB3	TOB1	-1.86894127400263	0.01953125
KICH	CPEB3	CNOT8	1.5062762229379	0.0255050659179687
THCA	CPEB3	CNOT7	-1.0100272557073	2.28966131184287e-07
LIHC	CPEB3	CNOT3	-1.23300348731276	3.17814170396599e-08
BRCA	CPEB3	CNOT3	-2.12666858749727	9.14937084127887e-14

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CPEB3

NXF1, Capn1, Capn2, EGLN3, KIAA1429, CPEB4,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CPEB3	chr10	93999268	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CPEB3	KIRP	chr10	93999658	93999658	A	C	Silent	p.T150T	4
CPEB3	KIRP	chr10	93812079	93812079	A	G	Missense_Mutation	p.C663R	4
CPEB3	BRCA	chr10	93952303	93952303	C	G	Missense_Mutation	p.G366R	4
CPEB3	LIHC	chr10	93902837	93902837	C	T	Missense_Mutation		4
CPEB3	ESCA	chr10	93999920	93999920	G	-	Frame_Shift_Del	p.P63fs	4
CPEB3	PAAD	chr10	93999697	93999697	C	A	Missense_Mutation	p.Q137H	3
CPEB3	COAD	chr10	93999850	93999850	A	G	Silent	p.P86P	3
CPEB3	UCEC	chr10	93940762	93940762	T	G	Missense_Mutation	p.N394H	2
CPEB3	ESCA	chr10	94000046	94000046	C	T	Missense_Mutation	p.R21Q	2
CPEB3	STAD	chr10	93999718	93999718	G	T	Silent	p.V130V	2
CPEB3	UCEC	chr10	93999139	93999140	-	A	Frame_Shift_Ins	p.R324fs	2
CPEB3	UCEC	chr10	93999739	93999739	G	A	Silent	p.F123	2
CPEB3	ESCA	chr10	94050746	94050746	T	-	Translation_Start_Site		2
CPEB3	UVM	chr10	93841258	93841258	A	G	Missense_Mutation		2
CPEB3	LIHC	chr10	93841110	93841110	A	-	Frame_Shift_Del	p.F598fs	2
CPEB3	KIRP	chr10	93812079	93812079	A	G	Missense_Mutation	p.C649R	2
CPEB3	SKCM	chr10	93952255	93952255	T	C	Missense_Mutation	p.M382V	2
CPEB3	LIHC	chr10	93870891	93870891	A	-	Frame_Shift_Del	p.L491fs	2
CPEB3	KIRP	chr10	93812079	93812079	A	G	Missense_Mutation		2
CPEB3	SKCM	chr10	93902842	93902842	G	A	Missense_Mutation	p.P452L	2
CPEB3	PRAD	chr10	93999747	93999747	C	G	Missense_Mutation	p.D121H	2
CPEB3	UCEC	chr10	93841238	93841238	C	T	Missense_Mutation	p.D570N	2
CPEB3	CESC	chr10	93904785	93904785	G	A	Missense_Mutation		2
CPEB3	SKCM	chr10	93902868	93902868	G	A	Silent	p.I443I	2
CPEB3	UCEC	chr10	93870875	93870875	T	G	Missense_Mutation	p.K510N	2
CPEB3	BLCA	chr10	93870839	93870839	G	T	Missense_Mutation		2
CPEB3	SKCM	chr10	93902843	93902843	G	A	Missense_Mutation	p.P452S	2
CPEB3	UCEC	chr10	93904752	93904752	C	T	Missense_Mutation	p.R438H	2
CPEB3	BLCA	chr10	93952323	93952323	G	C	Missense_Mutation	p.T359S	2
CPEB3	CESC	chr10	93812013	93812013	C	A	Nonsense_Mutation		2
CPEB3	LUAD	chr10	93851587	93851587	C	T	Splice_Site	p.V549_splice	2
CPEB3	STAD	chr10	93940759	93940759	A	G	Missense_Mutation	p.F395L	2
CPEB3	UCEC	chr10	93904779	93904779	C	T	Missense_Mutation	p.R429H	2
CPEB3	STAD	chr10	93841161	93841161	G	A	Silent	p.R595R	2
CPEB3	LIHC	chr10	93999597	93999597	G	A	Missense_Mutation	p.P171S	1
CPEB3	SARC	chr10	93999214	93999214	G	T	Missense_Mutation		1
CPEB3	SKCM	chr10	93851667	93851667	T	C	Missense_Mutation	p.D536G	1
CPEB3	BLCA	chr10	93904761	93904761	C	T	Missense_Mutation	p.R421Q	1
CPEB3	KIRC	chr10	93940719	93940720	-	T	Splice_Site	.	1
CPEB3	CESC	chr10	93999172	93999172	G	C	Silent	p.L312	1
CPEB3	LIHC	chr10	93812099	93812099	A	G	Missense_Mutation		1
CPEB3	LUAD	chr10	93904753	93904753	G	T	Missense_Mutation	p.R424S	1
CPEB3	SARC	chr10	93841117	93841117	G	T	Missense_Mutation		1
CPEB3	ESCA	chr10	93851666	93851666	G	T	Missense_Mutation	p.D522E	1
CPEB3	LIHC	chr10	93904731	93904731	A	G	Missense_Mutation	p.V445A	1
CPEB3	SKCM	chr10	93851667	93851667	T	C	Missense_Mutation	p.D522G	1
CPEB3	BLCA	chr10	93870928	93870928	C	A	Nonsense_Mutation	p.E479*	1
CPEB3	KIRC	chr10	93870873	93870874	-	G	Frame_Shift_Ins	p.L511fs	1
CPEB3	COAD	chr10	93841234	93841234	C	T	Missense_Mutation	p.R571H	1
CPEB3	LIHC	chr10	93999727	93999727	G	A	Silent		1
CPEB3	LUAD	chr10	93999919	93999920	-	G	Frame_Shift_Ins	p.R63fs	1
CPEB3	STAD	chr10	93999953	93999953	G	-	Frame_Shift_Del	p.A52fs	1
CPEB3	SARC	chr10	93904856	93904856	G	T	Silent		1
CPEB3	LIHC	chr10	93999727	93999727	G	A	Silent	p.I127I	1
CPEB3	SKCM	chr10	93841190	93841190	C	T	Missense_Mutation	p.E572K	1
CPEB3	BLCA	chr10	93999434	93999434	G	-	Frame_Shift_Del	p.A225fs	1
CPEB3	COAD	chr10	93904780	93904780	G	A	Missense_Mutation	p.R429C	1
CPEB3	LIHC	chr10	93902836	93902836	A	T	Missense_Mutation		1
CPEB3	LUSC	chr10	93841226	93841226	C	A	Missense_Mutation	p.G574C	1
CPEB3	THCA	chr10	94000047	94000049	GCT	-	In_Frame_Del	p.QR20del	1
CPEB3	SARC	chr10	93999648	93999648	G	T	Missense_Mutation		1
CPEB3	HNSC	chr10	93902855	93902855	G	A	Missense_Mutation		1
CPEB3	LIHC	chr10	93841114	93841114	C	T	Missense_Mutation	p.R611H	1
CPEB3	LIHC	chr10	93902837	93902837	C	T	Missense_Mutation	p.V454I	1
CPEB3	SKCM	chr10	93940758	93940758	A	G	Missense_Mutation	p.F372S	1
CPEB3	BLCA	chr10	93999375	93999385	GCGTGTTCCAG	-	Frame_Shift_Del	p.SWNTH241fs	1
CPEB3	COAD	chr10	93952355	93952355	C	T	Silent	p.S348S	1
CPEB3	LIHC	chr10	93952348	93952348	T	C	Missense_Mutation		1
CPEB3	LUSC	chr10	93999117	93999117	G	C	Missense_Mutation	p.L331V	1
CPEB3	THYM	chr10	93999850	93999850	A	G	Silent		1
CPEB3	SARC	chr10	93902837	93902837	C	G	Missense_Mutation	p.V454L	1
CPEB3	UVM	chr10	93841258	93841258	A	G	Missense_Mutation	p.V563A	1
CPEB3	HNSC	chr10	93851633	93851633	G	T	Silent		1
CPEB3	SKCM	chr10	93851681	93851681	G	A	Silent	p.N517N	1
CPEB3	COAD	chr10	93999102	93999102	C	A	Splice_Site	.	1
CPEB3	THYM	chr10	93999186	93999186	G	T	Missense_Mutation	p.R308S	1
CPEB3	UVM	chr10	93841258	93841258	A	G	Splice_Site	p.V549_splice	1
CPEB3	HNSC	chr10	93940750	93940750	G	A	Missense_Mutation		1
CPEB3	SKCM	chr10	93851593	93851593	G	A	Nonsense_Mutation	p.R547*	1
CPEB3	CESC	chr10	93999172	93999172	G	C	Silent		1
CPEB3	COAD	chr10	93999179	93999179	G	A	Missense_Mutation	p.A310V	1
CPEB3	LIHC	chr10	94000049	94000049	T	C	Missense_Mutation	p.Q20R	1
CPEB3	PCPG	chr10	93999562	93999562	T	A	Silent	p.P182P	1
CPEB3	UCEC	chr10	93999139	93999140	-	A	Frame_Shift_Ins	p.F323fs	1
CPEB3	SKCM	chr10	93940758	93940758	A	G	Missense_Mutation	p.F395S	1
CPEB3	UVM	chr10	93841258	93841258	A	G	Splice_Site	p.V549A	1
CPEB3	BLCA	chr10	93952323	93952323	G	C	Missense_Mutation		1
CPEB3	HNSC	chr10	93952390	93952390	G	A	Missense_Mutation		1
CPEB3	LIHC	chr10	93999254	93999254	G	-	Frame_Shift_Del	p.P285fs	1
CPEB3	CESC	chr10	93851621	93851621	G	C	Missense_Mutation		1
CPEB3	LGG	chr10	93940768	93940768	C	T	Missense_Mutation	p.G369R	1
CPEB3	LIHC	chr10	93904825	93904825	T	A	Missense_Mutation	p.S414C	1
CPEB3	SKCM	chr10	93902842	93902842	G	A	Missense_Mutation	p.P466L	1
CPEB3	BLCA	chr10	93904761	93904761	C	T	Missense_Mutation		1
CPEB3	HNSC	chr10	93940750	93940750	G	A	Missense_Mutation	p.P375S	1
CPEB3	LGG	chr10	93999628	93999628	G	T	Silent	p.T160T	1
CPEB3	LIHC	chr10	93999176	93999176	G	-	Frame_Shift_Del	p.P311fs	1
CPEB3	COAD	chr10	93812116	93812116	C	T	Silent	p.P650P	1
CPEB3	LIHC	chr10	93902837	93902837	C	T	Missense_Mutation	p.V468I	1
CPEB3	PRAD	chr10	93999536	93999536	C	A	Missense_Mutation	p.R191L	1
CPEB3	SKCM	chr10	93902843	93902843	G	A	Missense_Mutation	p.P466S	1
CPEB3	HNSC	chr10	93902855	93902855	G	A	Missense_Mutation	p.R448C	1
CPEB3	CESC	chr10	93812113	93812113	G	C	Missense_Mutation		1
CPEB3	LGG	chr10	93870871	93870872	AG	-	Frame_Shift_Del	p.LY497fs	1
CPEB3	LIHC	chr10	94000094	94000094	A	-	Frame_Shift_Del	p.L6fs	1
CPEB3	COAD	chr10	93812149	93812149	G	T	Nonsense_Mutation	p.C639X	1
CPEB3	LIHC	chr10	93811980	93811980	G	A	Missense_Mutation	p.R696C	1
CPEB3	PRAD	chr10	93902802	93902802	A	T	Silent	p.S465S	1
CPEB3	SKCM	chr10	93902868	93902868	G	A	Silent	p.I457I	1
CPEB3	HNSC	chr10	93952390	93952390	G	A	Missense_Mutation	p.R337W	1
CPEB3	LGG	chr10	93940768	93940768	C	T	Missense_Mutation		1
CPEB3	LIHC	chr10	93999237	93999237	G	A	Missense_Mutation	p.P291S	1
CPEB3	PRAD	chr10	93851634	93851634	G	T	Missense_Mutation	p.P533H	1
CPEB3	SKCM	chr10	93851681	93851681	G	A	Silent	p.N531N	1
CPEB3	BLCA	chr10	93841145	93841145	G	A	Nonsense_Mutation	p.Q587*	1
CPEB3	HNSC	chr10	93902855	93902855	G	A	Missense_Mutation	p.R462C	1
CPEB3	CESC	chr10	93904785	93904785	G	A	Missense_Mutation	p.P427L	1
CPEB3	LGG	chr10	93999147	93999147	T	C	Missense_Mutation		1
CPEB3	LUAD	chr10	93902846	93902846	C	G	Missense_Mutation	p.G451R	1

Copy number variation (CNV) of CPEB3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CPEB3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101300	N/A	BF986123	CHCHD3	chr7	132599669	+	CPEB3	chr10	93964889	+
91359	N/A	EC580071	CPEB3	chr10	93809234	-	CACNB2	chr10	18508179	+
101300	N/A	DW462381	CPEB3	chr10	93987193	-	CPEB3	chr10	93988264	-
101646	N/A	CS674272	CPEB3	chr10	93884870	-	CYP2S1	chr19	41700303	+
74775	N/A	EC459240	CPEB3	chr10	93976331	-	NHP2	chr5	177577969	-
74775	N/A	EC548178	CPEB3	chr10	93976601	-	NHP2	chr5	177576643	-
102684	PRAD	TCGA-HC-A631-01A	CPEB3	chr10	93841077	-	PRIM1	chr12	57140816	-
101527	N/A	AX185025	CPEB3	chr10	93948403	-	RPRD2	chr1	150341838	+
101300	N/A	CB047909	EGFLAM	chr5	38464491	+	CPEB3	chr10	94040121	+
101300	N/A	EC527506	KIF11	chr10	94355011	-	CPEB3	chr10	93988267	-
101300	N/A	BC043362	LDLRAD2	chr1	22149041	+	CPEB3	chr10	93976771	+
101300	N/A	AI832185	MARCH5	chr10	94065126	-	CPEB3	chr10	93967564	-
101300	N/A	AW129709	MYC	chr8	128753124	-	CPEB3	chr10	93952082	+
101313	UCEC	TCGA-5B-A90C	ZMIZ1	chr10	80976031	+	CPEB3	chr10	93904869	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CPEB3	0.000195156169239497	0.0055

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CPEB3	0.0372863623552894	1
KICH	CPEB3	0.0314419616602323	0.94
LGG	CPEB3	2.39222702175203e-05	0.00079
BLCA	CPEB3	0.0392153330432193	1
THYM	CPEB3	0.0273967265825723	0.85
SARC	CPEB3	0.00725354816027892	0.23

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C2239176	Liver carcinoma	1	CTD_human