Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: LARP1 (NCBI Gene ID:23367)

Gene Summary

Gene Summary

Gene Information	Gene Name: LARP1
	Gene ID: 23367
	Gene Symbol	LARP1
	Gene ID	23367
	Gene Name	La ribonucleoprotein 1, translational regulator
	Synonyms	LARP\|Lar1\|Lhp1
	Cytomap	5q33.2
	Type of Gene	protein-coding
	Description	la-related protein 1La ribonucleoprotein domain family member 1
	Modification date	20200313
	UniProtAcc	Q6PKG0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'LARP1[title] AND translation [title] AND human.'

Gene	Title	PMID
LARP1	Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5' TOP motifs	32094190

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BLCA	LARP1	-3.14511945488335	0.0108261108398438
PRAD	LARP1	-4.32858209458213	1.02977929185394e-06
LIHC	LARP1	-2.87067203862976	2.96133940972468e-07

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
COAD	LARP1	3	2	0.0034191834510082	0.626999165448343	0.570195331325299	0.519497950044696	0.352365631296078

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with LARP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	LARP1	MGAT5	0.810748972	1.48E-11
CHOL	Cell metabolism gene	LARP1	GALNT10	0.822150068	4.38E-12
CHOL	Epifactor	LARP1	KDM3B	0.822375455	4.28E-12
CHOL	IUPHAR	LARP1	SLC36A1	0.820625258	5.18E-12
CHOL	IUPHAR	LARP1	KDM3B	0.822375455	4.28E-12
CHOL	TF	LARP1	ZNF207	0.857442857	5.48E-14
CHOL	TSG	LARP1	KDM3B	0.822375455	4.28E-12
DLBC	Cell metabolism gene	LARP1	MCCC2	0.800374764	8.67E-12
DLBC	Cell metabolism gene	LARP1	NUP153	0.801184892	7.97E-12
DLBC	Cell metabolism gene	LARP1	PATL1	0.806885421	4.36E-12
DLBC	Cell metabolism gene	LARP1	SMG1	0.807093975	4.27E-12
DLBC	Cell metabolism gene	LARP1	ACLY	0.825628552	5.17E-13
DLBC	Cell metabolism gene	LARP1	EP300	0.836610555	1.31E-13
DLBC	Cell metabolism gene	LARP1	MED1	0.845223313	4.17E-14
DLBC	Cell metabolism gene	LARP1	POLR3A	0.857397269	7.27E-15
DLBC	CGC	LARP1	APC	0.802413508	7.01E-12
DLBC	CGC	LARP1	TRRAP	0.806873067	4.37E-12
DLBC	CGC	LARP1	NUP98	0.812779309	2.29E-12
DLBC	CGC	LARP1	BRD4	0.819149226	1.11E-12
DLBC	CGC	LARP1	KRAS	0.819763386	1.03E-12
DLBC	CGC	LARP1	BIRC6	0.825039617	5.55E-13
DLBC	CGC	LARP1	SUZ12	0.827530251	4.11E-13
DLBC	CGC	LARP1	CBL	0.828740139	3.54E-13
DLBC	CGC	LARP1	EP300	0.836610555	1.31E-13
DLBC	CGC	LARP1	PTPN11	0.857417028	7.25E-15
DLBC	Epifactor	LARP1	CHD7	0.801644548	7.60E-12
DLBC	Epifactor	LARP1	TRRAP	0.806873067	4.37E-12
DLBC	Epifactor	LARP1	DDX21	0.80734068	4.15E-12
DLBC	Epifactor	LARP1	BRD4	0.819149226	1.11E-12
DLBC	Epifactor	LARP1	ADNP	0.819295463	1.09E-12
DLBC	Epifactor	LARP1	SUZ12	0.827530251	4.11E-13
DLBC	Epifactor	LARP1	CHD8	0.835131802	1.59E-13
DLBC	Epifactor	LARP1	EP300	0.836610555	1.31E-13
DLBC	IUPHAR	LARP1	HIPK3	0.802499646	6.95E-12
DLBC	IUPHAR	LARP1	SLC7A1	0.80256933	6.90E-12
DLBC	IUPHAR	LARP1	LMTK2	0.804687211	5.52E-12
DLBC	IUPHAR	LARP1	TRRAP	0.806873067	4.37E-12
DLBC	IUPHAR	LARP1	SMG1	0.807093975	4.27E-12
DLBC	IUPHAR	LARP1	GPR75	0.807322128	4.16E-12
DLBC	IUPHAR	LARP1	SLC16A7	0.807782301	3.96E-12
DLBC	IUPHAR	LARP1	BRD4	0.819149226	1.11E-12
DLBC	IUPHAR	LARP1	KRAS	0.819763386	1.03E-12
DLBC	IUPHAR	LARP1	BIRC6	0.825039617	5.55E-13
DLBC	IUPHAR	LARP1	EP300	0.836610555	1.31E-13
DLBC	IUPHAR	LARP1	ATP2A2	0.845309276	4.12E-14
DLBC	Kinase	LARP1	HIPK3	0.802499646	6.95E-12
DLBC	Kinase	LARP1	LMTK2	0.804687211	5.52E-12
DLBC	Kinase	LARP1	TRRAP	0.806873067	4.37E-12
DLBC	Kinase	LARP1	SMG1	0.807093975	4.27E-12
DLBC	Kinase	LARP1	BRD4	0.819149226	1.11E-12
DLBC	TF	LARP1	HIC2	0.80012537	8.90E-12
DLBC	TF	LARP1	ETV3	0.805049938	5.31E-12
DLBC	TF	LARP1	ZNF609	0.808234145	3.77E-12
DLBC	TF	LARP1	ADNP	0.819295463	1.09E-12
DLBC	TF	LARP1	ZBTB39	0.83050621	2.85E-13
DLBC	TF	LARP1	ATF7	0.83543332	1.53E-13
DLBC	TSG	LARP1	RBL1	0.802009228	7.32E-12
DLBC	TSG	LARP1	APC	0.802413508	7.01E-12
DLBC	TSG	LARP1	RASSF3	0.807934908	3.90E-12
DLBC	TSG	LARP1	NUP98	0.812779309	2.29E-12
DLBC	TSG	LARP1	SUZ12	0.827530251	4.11E-13
DLBC	TSG	LARP1	CBL	0.828740139	3.54E-13
DLBC	TSG	LARP1	ANAPC1	0.83509353	1.60E-13
DLBC	TSG	LARP1	PTPN11	0.857417028	7.25E-15
GBM	Cell metabolism gene	LARP1	POLR2A	0.802735581	5.17E-40
GBM	Epifactor	LARP1	HUWE1	0.830668345	4.27E-45
GBM	Epifactor	LARP1	SUPT6H	0.835650142	4.22E-46
GBM	Epifactor	LARP1	KDM2A	0.844471757	5.77E-48
GBM	Epifactor	LARP1	MECP2	0.861671456	5.88E-52
GBM	IUPHAR	LARP1	PDPK1	0.806113155	1.39E-40
GBM	IUPHAR	LARP1	KDM2A	0.844471757	5.77E-48
GBM	Kinase	LARP1	PDPK1	0.806113155	1.39E-40
GBM	TF	LARP1	ZNF37A	0.801568929	8.09E-40
GBM	TF	LARP1	ZNF142	0.813025969	8.72E-42
GBM	TF	LARP1	KDM2A	0.844471757	5.77E-48
GBM	TF	LARP1	ZNF407	0.85582716	1.53E-50
GBM	TF	LARP1	MECP2	0.861671456	5.88E-52
TGCT	Cell metabolism gene	LARP1	PHAX	0.816153532	1.63E-38
TGCT	CGC	LARP1	STIL	0.836838701	3.88E-42
TGCT	Epifactor	LARP1	SIRT1	0.838796392	1.66E-42
TGCT	IUPHAR	LARP1	SIRT1	0.838796392	1.66E-42
TGCT	TSG	LARP1	SIRT1	0.838796392	1.66E-42
THYM	Cell metabolism gene	LARP1	ITPR3	0.801335079	1.51E-28
THYM	Cell metabolism gene	LARP1	PRKAR2A	0.809226428	1.71E-29
THYM	Cell metabolism gene	LARP1	MGAT5	0.810179082	1.30E-29
THYM	Cell metabolism gene	LARP1	PIK3C2A	0.811126643	9.95E-30
THYM	Cell metabolism gene	LARP1	AZIN1	0.817622436	1.50E-30
THYM	Cell metabolism gene	LARP1	TNPO1	0.817698709	1.46E-30
THYM	Cell metabolism gene	LARP1	PAFAH1B2	0.821312825	4.94E-31
THYM	Cell metabolism gene	LARP1	GPD2	0.822994536	2.96E-31
THYM	Cell metabolism gene	LARP1	PIP4K2C	0.823208382	2.77E-31
THYM	Cell metabolism gene	LARP1	LMAN1	0.824915224	1.63E-31
THYM	Cell metabolism gene	LARP1	KIF13A	0.833195104	1.16E-32
THYM	Cell metabolism gene	LARP1	GNA11	0.841010142	8.33E-34
THYM	Cell metabolism gene	LARP1	ARFGEF2	0.859193138	1.01E-36
THYM	Cell metabolism gene	LARP1	RRM2B	0.86584984	6.77E-38
THYM	CGC	LARP1	CTNND1	0.804144821	7.02E-29
THYM	CGC	LARP1	TET2	0.807090797	3.11E-29
THYM	CGC	LARP1	HIP1	0.817589988	1.51E-30
THYM	CGC	LARP1	PALB2	0.819774022	7.87E-31
THYM	CGC	LARP1	PAFAH1B2	0.821312825	4.94E-31
THYM	CGC	LARP1	GOLGA5	0.837429623	2.83E-33
THYM	CGC	LARP1	NBN	0.837573587	2.70E-33
THYM	CGC	LARP1	GNA11	0.841010142	8.33E-34
THYM	CGC	LARP1	NFE2L2	0.852202661	1.48E-35
THYM	CGC	LARP1	MAP3K13	0.855781582	3.81E-36
THYM	CGC	LARP1	AFF4	0.861161639	4.60E-37
THYM	CGC	LARP1	CLIP1	0.870315368	1.02E-38
THYM	Epifactor	LARP1	ADNP	0.802397835	1.13E-28
THYM	Epifactor	LARP1	DDX21	0.804817699	5.84E-29
THYM	Epifactor	LARP1	USP12	0.805404922	4.96E-29
THYM	Epifactor	LARP1	TET2	0.807090797	3.11E-29
THYM	Epifactor	LARP1	RPS6KA5	0.82023028	6.86E-31
THYM	Epifactor	LARP1	BRMS1L	0.830522682	2.77E-32
THYM	Epifactor	LARP1	CHD6	0.833229618	1.15E-32
THYM	Epifactor	LARP1	NBN	0.837573587	2.70E-33
THYM	Epifactor	LARP1	ASH1L	0.855016349	5.11E-36
THYM	IUPHAR	LARP1	ITPR3	0.801335079	1.51E-28
THYM	IUPHAR	LARP1	IDE	0.802264044	1.17E-28
THYM	IUPHAR	LARP1	ADAM17	0.808419656	2.14E-29
THYM	IUPHAR	LARP1	PRKAR2A	0.809226428	1.71E-29
THYM	IUPHAR	LARP1	FZD6	0.809297837	1.67E-29
THYM	IUPHAR	LARP1	BCL2L2	0.810836489	1.08E-29
THYM	IUPHAR	LARP1	PIK3C2A	0.811126643	9.95E-30
THYM	IUPHAR	LARP1	LMTK2	0.811306689	9.45E-30
THYM	IUPHAR	LARP1	ATP2A2	0.812619202	6.48E-30
THYM	IUPHAR	LARP1	HIPK3	0.812705823	6.32E-30
THYM	IUPHAR	LARP1	SLC38A7	0.813961022	4.40E-30
THYM	IUPHAR	LARP1	RPS6KC1	0.814134505	4.18E-30
THYM	IUPHAR	LARP1	NIPAL2	0.815967123	2.44E-30
THYM	IUPHAR	LARP1	STK35	0.816018524	2.41E-30
THYM	IUPHAR	LARP1	TBK1	0.818920931	1.02E-30
THYM	IUPHAR	LARP1	RPS6KA5	0.82023028	6.86E-31
THYM	IUPHAR	LARP1	TWF1	0.820313782	6.69E-31
THYM	IUPHAR	LARP1	PIP4K2C	0.823208382	2.77E-31
THYM	IUPHAR	LARP1	SLC30A4	0.825122846	1.53E-31
THYM	IUPHAR	LARP1	PREPL	0.828464798	5.35E-32
THYM	IUPHAR	LARP1	SLK	0.830102821	3.17E-32
THYM	IUPHAR	LARP1	SLC30A6	0.838494656	1.97E-33
THYM	IUPHAR	LARP1	TRIO	0.83898172	1.67E-33
THYM	IUPHAR	LARP1	NPTN	0.839323005	1.49E-33
THYM	IUPHAR	LARP1	SLC39A6	0.842170169	5.57E-34
THYM	IUPHAR	LARP1	SLC30A5	0.847453771	8.52E-35
THYM	IUPHAR	LARP1	NFE2L2	0.852202661	1.48E-35
THYM	IUPHAR	LARP1	ATP6V1A	0.854059545	7.36E-36
THYM	IUPHAR	LARP1	CLCN3	0.854738008	5.68E-36
THYM	IUPHAR	LARP1	ASH1L	0.855016349	5.11E-36
THYM	IUPHAR	LARP1	MAP3K13	0.855781582	3.81E-36
THYM	IUPHAR	LARP1	RRM2B	0.86584984	6.77E-38
THYM	IUPHAR	LARP1	PDPK1	0.868262289	2.46E-38
THYM	Kinase	LARP1	LMTK2	0.811306689	9.45E-30
THYM	Kinase	LARP1	HIPK3	0.812705823	6.32E-30
THYM	Kinase	LARP1	RPS6KC1	0.814134505	4.18E-30
THYM	Kinase	LARP1	STK35	0.816018524	2.41E-30
THYM	Kinase	LARP1	TBK1	0.818920931	1.02E-30
THYM	Kinase	LARP1	RPS6KA5	0.82023028	6.86E-31
THYM	Kinase	LARP1	SLK	0.830102821	3.17E-32
THYM	Kinase	LARP1	TRIO	0.83898172	1.67E-33
THYM	Kinase	LARP1	MAP3K13	0.855781582	3.81E-36
THYM	Kinase	LARP1	PDPK1	0.868262289	2.46E-38
THYM	TF	LARP1	ATF6	0.800898121	1.70E-28
THYM	TF	LARP1	ZNF426	0.802130434	1.22E-28
THYM	TF	LARP1	ADNP	0.802397835	1.13E-28
THYM	TF	LARP1	NFIC	0.806343355	3.83E-29
THYM	TF	LARP1	TET2	0.807090797	3.11E-29
THYM	TF	LARP1	ZNF28	0.811264838	9.56E-30
THYM	TF	LARP1	ZNF432	0.812844541	6.07E-30
THYM	TF	LARP1	ZNF623	0.815795181	2.57E-30
THYM	TF	LARP1	ADNP2	0.81591684	2.48E-30
THYM	TF	LARP1	ETV3	0.818730635	1.08E-30
THYM	TF	LARP1	ZNF791	0.821396909	4.82E-31
THYM	TF	LARP1	ZBTB41	0.822766728	3.17E-31
THYM	TF	LARP1	ZXDB	0.824781617	1.70E-31
THYM	TF	LARP1	RREB1	0.827019038	8.45E-32
THYM	TF	LARP1	NFXL1	0.827194075	7.99E-32
THYM	TF	LARP1	EEA1	0.828802601	4.80E-32
THYM	TF	LARP1	KLF3	0.840511723	9.90E-34
THYM	TF	LARP1	ZNF710	0.843907344	3.03E-34
THYM	TF	LARP1	HIVEP1	0.844170714	2.76E-34
THYM	TF	LARP1	NFE2L2	0.852202661	1.48E-35
THYM	TF	LARP1	ASH1L	0.855016349	5.11E-36
THYM	TSG	LARP1	CTNND1	0.804144821	7.02E-29
THYM	TSG	LARP1	USP12	0.805404922	4.96E-29
THYM	TSG	LARP1	TET2	0.807090797	3.11E-29
THYM	TSG	LARP1	TP53BP2	0.807229868	2.99E-29
THYM	TSG	LARP1	PALB2	0.819774022	7.87E-31
THYM	TSG	LARP1	NBN	0.837573587	2.70E-33
THYM	TSG	LARP1	HIVEP1	0.844170714	2.76E-34
UCS	Cell metabolism gene	LARP1	ITPR3	0.801335079	1.51E-28
UCS	Cell metabolism gene	LARP1	PRKAR2A	0.809226428	1.71E-29
UCS	Cell metabolism gene	LARP1	MGAT5	0.810179082	1.30E-29
UCS	Cell metabolism gene	LARP1	PIK3C2A	0.811126643	9.95E-30
UCS	Cell metabolism gene	LARP1	AZIN1	0.817622436	1.50E-30
UCS	Cell metabolism gene	LARP1	TNPO1	0.817698709	1.46E-30
UCS	Cell metabolism gene	LARP1	PAFAH1B2	0.821312825	4.94E-31
UCS	Cell metabolism gene	LARP1	GPD2	0.822994536	2.96E-31
UCS	Cell metabolism gene	LARP1	PIP4K2C	0.823208382	2.77E-31
UCS	Cell metabolism gene	LARP1	LMAN1	0.824915224	1.63E-31
UCS	Cell metabolism gene	LARP1	KIF13A	0.833195104	1.16E-32
UCS	Cell metabolism gene	LARP1	GNA11	0.841010142	8.33E-34
UCS	Cell metabolism gene	LARP1	ARFGEF2	0.859193138	1.01E-36
UCS	Cell metabolism gene	LARP1	RRM2B	0.86584984	6.77E-38
UCS	CGC	LARP1	CTNND1	0.804144821	7.02E-29
UCS	CGC	LARP1	TET2	0.807090797	3.11E-29
UCS	CGC	LARP1	HIP1	0.817589988	1.51E-30
UCS	CGC	LARP1	PALB2	0.819774022	7.87E-31
UCS	CGC	LARP1	PAFAH1B2	0.821312825	4.94E-31
UCS	CGC	LARP1	GOLGA5	0.837429623	2.83E-33
UCS	CGC	LARP1	NBN	0.837573587	2.70E-33
UCS	CGC	LARP1	GNA11	0.841010142	8.33E-34
UCS	CGC	LARP1	NFE2L2	0.852202661	1.48E-35
UCS	CGC	LARP1	MAP3K13	0.855781582	3.81E-36
UCS	CGC	LARP1	AFF4	0.861161639	4.60E-37
UCS	CGC	LARP1	CLIP1	0.870315368	1.02E-38
UCS	Epifactor	LARP1	ADNP	0.802397835	1.13E-28
UCS	Epifactor	LARP1	DDX21	0.804817699	5.84E-29
UCS	Epifactor	LARP1	USP12	0.805404922	4.96E-29
UCS	Epifactor	LARP1	TET2	0.807090797	3.11E-29
UCS	Epifactor	LARP1	RPS6KA5	0.82023028	6.86E-31
UCS	Epifactor	LARP1	BRMS1L	0.830522682	2.77E-32
UCS	Epifactor	LARP1	CHD6	0.833229618	1.15E-32
UCS	Epifactor	LARP1	NBN	0.837573587	2.70E-33
UCS	Epifactor	LARP1	ASH1L	0.855016349	5.11E-36
UCS	IUPHAR	LARP1	ITPR3	0.801335079	1.51E-28
UCS	IUPHAR	LARP1	IDE	0.802264044	1.17E-28
UCS	IUPHAR	LARP1	ADAM17	0.808419656	2.14E-29
UCS	IUPHAR	LARP1	PRKAR2A	0.809226428	1.71E-29
UCS	IUPHAR	LARP1	FZD6	0.809297837	1.67E-29
UCS	IUPHAR	LARP1	BCL2L2	0.810836489	1.08E-29
UCS	IUPHAR	LARP1	PIK3C2A	0.811126643	9.95E-30
UCS	IUPHAR	LARP1	LMTK2	0.811306689	9.45E-30
UCS	IUPHAR	LARP1	ATP2A2	0.812619202	6.48E-30
UCS	IUPHAR	LARP1	HIPK3	0.812705823	6.32E-30
UCS	IUPHAR	LARP1	SLC38A7	0.813961022	4.40E-30
UCS	IUPHAR	LARP1	RPS6KC1	0.814134505	4.18E-30
UCS	IUPHAR	LARP1	NIPAL2	0.815967123	2.44E-30
UCS	IUPHAR	LARP1	STK35	0.816018524	2.41E-30
UCS	IUPHAR	LARP1	TBK1	0.818920931	1.02E-30
UCS	IUPHAR	LARP1	RPS6KA5	0.82023028	6.86E-31
UCS	IUPHAR	LARP1	TWF1	0.820313782	6.69E-31
UCS	IUPHAR	LARP1	PIP4K2C	0.823208382	2.77E-31
UCS	IUPHAR	LARP1	SLC30A4	0.825122846	1.53E-31
UCS	IUPHAR	LARP1	PREPL	0.828464798	5.35E-32
UCS	IUPHAR	LARP1	SLK	0.830102821	3.17E-32
UCS	IUPHAR	LARP1	SLC30A6	0.838494656	1.97E-33
UCS	IUPHAR	LARP1	TRIO	0.83898172	1.67E-33
UCS	IUPHAR	LARP1	NPTN	0.839323005	1.49E-33
UCS	IUPHAR	LARP1	SLC39A6	0.842170169	5.57E-34
UCS	IUPHAR	LARP1	SLC30A5	0.847453771	8.52E-35
UCS	IUPHAR	LARP1	NFE2L2	0.852202661	1.48E-35
UCS	IUPHAR	LARP1	ATP6V1A	0.854059545	7.36E-36
UCS	IUPHAR	LARP1	CLCN3	0.854738008	5.68E-36
UCS	IUPHAR	LARP1	ASH1L	0.855016349	5.11E-36
UCS	IUPHAR	LARP1	MAP3K13	0.855781582	3.81E-36
UCS	IUPHAR	LARP1	RRM2B	0.86584984	6.77E-38
UCS	IUPHAR	LARP1	PDPK1	0.868262289	2.46E-38
UCS	Kinase	LARP1	LMTK2	0.811306689	9.45E-30
UCS	Kinase	LARP1	HIPK3	0.812705823	6.32E-30
UCS	Kinase	LARP1	RPS6KC1	0.814134505	4.18E-30
UCS	Kinase	LARP1	STK35	0.816018524	2.41E-30
UCS	Kinase	LARP1	TBK1	0.818920931	1.02E-30
UCS	Kinase	LARP1	RPS6KA5	0.82023028	6.86E-31
UCS	Kinase	LARP1	SLK	0.830102821	3.17E-32
UCS	Kinase	LARP1	TRIO	0.83898172	1.67E-33
UCS	Kinase	LARP1	MAP3K13	0.855781582	3.81E-36
UCS	Kinase	LARP1	PDPK1	0.868262289	2.46E-38
UCS	TF	LARP1	ATF6	0.800898121	1.70E-28
UCS	TF	LARP1	ZNF426	0.802130434	1.22E-28
UCS	TF	LARP1	ADNP	0.802397835	1.13E-28
UCS	TF	LARP1	NFIC	0.806343355	3.83E-29
UCS	TF	LARP1	TET2	0.807090797	3.11E-29
UCS	TF	LARP1	ZNF28	0.811264838	9.56E-30
UCS	TF	LARP1	ZNF432	0.812844541	6.07E-30
UCS	TF	LARP1	ZNF623	0.815795181	2.57E-30
UCS	TF	LARP1	ADNP2	0.81591684	2.48E-30
UCS	TF	LARP1	ETV3	0.818730635	1.08E-30
UCS	TF	LARP1	ZNF791	0.821396909	4.82E-31
UCS	TF	LARP1	ZBTB41	0.822766728	3.17E-31
UCS	TF	LARP1	ZXDB	0.824781617	1.70E-31
UCS	TF	LARP1	RREB1	0.827019038	8.45E-32
UCS	TF	LARP1	NFXL1	0.827194075	7.99E-32
UCS	TF	LARP1	EEA1	0.828802601	4.80E-32
UCS	TF	LARP1	KLF3	0.840511723	9.90E-34
UCS	TF	LARP1	ZNF710	0.843907344	3.03E-34
UCS	TF	LARP1	HIVEP1	0.844170714	2.76E-34
UCS	TF	LARP1	NFE2L2	0.852202661	1.48E-35
UCS	TF	LARP1	ASH1L	0.855016349	5.11E-36
UCS	TSG	LARP1	CTNND1	0.804144821	7.02E-29
UCS	TSG	LARP1	USP12	0.805404922	4.96E-29
UCS	TSG	LARP1	TET2	0.807090797	3.11E-29
UCS	TSG	LARP1	TP53BP2	0.807229868	2.99E-29
UCS	TSG	LARP1	PALB2	0.819774022	7.87E-31
UCS	TSG	LARP1	NBN	0.837573587	2.70E-33
UCS	TSG	LARP1	HIVEP1	0.844170714	2.76E-34

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	LARP1	RPS6	-3.4556058277803	0.0001224322154943
KICH	LARP1	PABPC4	-1.36755201178157	0.000287055969238281
HNSC	LARP1	C19orf66	-2.03919151204058	0.000434366491617767
THCA	LARP1	RPS6	1.46346143665389	0.00305071956645465
CHOL	LARP1	C19orf66	-2.73832331278689	0.00390625
CHOL	LARP1	PABPC1	-4.56272528815353	0.00390625
CHOL	LARP1	RPTOR	-2.34317187916664	0.00390625
KICH	LARP1	EIF4G1	-1.46656081150743	0.00612920522689819
KIRP	LARP1	RPS6	-1.15360907834159	0.0111397774890065
COAD	LARP1	RPS6	1.03379589520851	0.011966735124588
BLCA	LARP1	RPS6	-1.76940777579938	0.012359619140625
BLCA	LARP1	PABPC1	1.31485302792746	0.0180816650390625
KIRC	LARP1	PABPC4	-1.49233512628432	1.55238188425888e-10
PRAD	LARP1	C19orf66	1.28911890176209	1.82900102684565e-05
COAD	LARP1	PABPC4	-2.03666372801907	2.27093696594239e-05
LIHC	LARP1	PABPC1	-1.72076961362188	2.98009622125841e-06
KIRP	LARP1	PABPC4	-2.80798320382911	2.98023223876953e-07
BRCA	LARP1	YBX1	1.10467241966451	4.8741280959683e-05
THCA	LARP1	PABPC4	-4.00250200468713	4.88626066707067e-07
KICH	LARP1	EIF4E	1.61675210562671	6.55651092529297e-06
LIHC	LARP1	RPTOR	-4.36362270436135	6.64579404273587e-07
PRAD	LARP1	MTOR	2.45767376269894	8.16442831201447e-07
KICH	LARP1	YBX1	1.86923259160472	8.16583633422851e-06
PRAD	LARP1	PABPC1	-2.10200318363476	8.55379952759014e-07
KIRC	LARP1	C19orf66	-1.45355250121598	8.86342871857849e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with LARP1

YWHAG, YWHAB, YWHAQ, YWHAZ, RRP1B, Ybx1, BCL2L1, TNNT1, ELAVL1, SIRT7, TSG101, NFX1, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, CAND1, GRK5, SLC25A10, CDCA5, BARD1, ECT2, PAXIP1, CSNK2A1, YWHAE, ITGA4, SOX2, CLK3, SRPK1, TARDBP, EIF3A, EIF3C, EIF3E, EIF3L, EIF3K, RPS10, RPS12, RPS13, RPS14, RPS16, RPS18, RPS29, RPS3, RPS3A, RPS4X, RPS5, RPS8, RPS9, LIN28A, IVNS1ABP, AURKA, CCDC155, EZH2, SUZ12, RNF2, HIST1H1A, NOL12, SURF2, TRA2A, RPL6, NIFK, HNRNPDL, ZC3H3, HNRNPA1, PRR11, LUC7L, ILF2, LUC7L2, SNIP1, NLRP2, NTRK1, IFI16, gag, HNRNPU, CNOT2, NPM1, RPL10, NOP56, Eif3a, Pabpc1, Rpl35, Srp72, Rrbp1, FOXG1, FOXL2, FOXQ1, Ksr1, U2AF2, RC3H1, CDH1, LARP1B, GSPT2, SNRNP70, ZC3HAV1, ZCRB1, APOBEC3D, SART3, HIST1H1E, PPAN, DGCR8, ELAVL2, STRBP, FGF8, ZFC3H1, BHLHA15, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, CGN, RTKN, MAST3, LIMA1, MAGI1, TESK2, PPM1H, DCLK1, ZNF638, CBY1, DLD, TRIM25, G3BP1, BRCA1, HNRNPL, TRIM14, HBP1, WDR77, CSNK1A1, HSPA8, PYHIN1, PIH1D1, EFTUD2, RPTOR, MTOR, MLST8, PABPC1, RPL29, TNIP2, CHD3, CHD4, RNF31, CDC34, MEPCE, LARP7, DPF2, RNF123, SNAI1, AGR2, RECQL4, CDK9, FBL, HIST1H3A, KIAA1429, RC3H2, ATG16L1, PHB, NR2C2, PPP1CC, GBF1, DCAF15, OASL, MOV10, FUS, TAF15, MATR3, CYLD, HMGB1, RHBDD1, RHBDF2, N, BIRC3, WWP2, CMTR1, PLEKHA4, HNRNPD, PINK1, ZC3H18, DUSP1, ELK4, LRRC31, CIT, ANLN, AURKB, CHMP4C, KIF14, KIF20A, KIF23, PRC1, MNDA, HNRNPH1, LRRC59, INS, NDN, Rnf183, MAFB, BRD4, RBM45, C18orf8, CIC, Apc2, RBM39, MKRN1, USP10, PABPC4, MKRN2, MKRN3, GLE1, AR, UFL1, DDRGK1, RPS20, SERBP1, FZR1, WDR5, PAGE4, NAA40, EDEM1, HNRNPUL2, RPS19, YBX1, SRSF5, HNRNPC, PRR3, SRSF4, RBMS2, FAM120A, LIN28B, H1FNT, YBX2, KRR1, ABT1, PABPC5, PAIP2B, RPL17, HNRNPCL1, RPL26, SRSF6, FGF13, NUPL2, RPS6, PURG, REXO4, SRSF3, LARP4B, PAIP1, RPL31, SNRPC, RPS2, IL17B, CBX6, SRSF7, SRSF1, THAP3, NEIL1, MYBBP1A, ZNF346, RPSA, RPSAP58, RPL35, HIST1H2AM, FGFBP1, RBM47, RPL36AL, RPLP0, RBM4B, BTF3, ESR1, EP300, FBXW7, Ywhaz, Rbm47, Dusp14, OPTN, TAX1BP1, SIRT6, CPEB1, KLF15, RB1CC1, KLF16, KLF4, KLF5, KLF8, MAGEL2,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
LARP1	chr5	154173386	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
LARP1	chr5	154190810	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
LARP1	ACC	chr5	154173390	154173390	C	-	Frame_Shift_Del	p.A223fs	8
LARP1	KIRP	chr5	154183178	154183178	T	A	Missense_Mutation	p.V694D	6
LARP1	KIRC	chr5	154179286	154179286	T	A	Missense_Mutation	p.F428I	5
LARP1	COAD	chr5	154181822	154181822	G	-	Frame_Shift_Del	p.P580fs	4
LARP1	LIHC	chr5	154181822	154181822	G	-	Frame_Shift_Del	p.G582fs	4
LARP1	UCEC	chr5	154173816	154173816	G	A	Missense_Mutation	p.R332H	4
LARP1	STAD	chr5	154173390	154173391	-	C	Frame_Shift_Ins	p.A223fs	4
LARP1	BRCA	chr5	154185485	154185485	G	T	Missense_Mutation	p.C787F	4
LARP1	UCS	chr5	154179268	154179268	C	T	Missense_Mutation	p.L422F	3
LARP1	UCS	chr5	154183841	154183841	G	T	Missense_Mutation	p.E763D	3
LARP1	PRAD	chr5	154190896	154190896	C	T	Missense_Mutation	p.T901M	3
LARP1	ESCA	chr5	154172210	154172210	G	T	Missense_Mutation	p.R121L	3
LARP1	UVM	chr5	154173236	154173236	G	A	Missense_Mutation	p.R197H	3
LARP1	ESCA	chr5	154181697	154181697	T	C	Missense_Mutation	p.M539T	3
LARP1	UCEC	chr5	154092583	154092583	C	T	Missense_Mutation	p.P33L	3
LARP1	LIHC	chr5	154193447	154193447	C	-	Splice_Site	p.P952_splice	3
LARP1	UCEC	chr5	154173191	154173191	T	C	Missense_Mutation	p.M182T	3
LARP1	PAAD	chr5	154179551	154179551	G	A	Silent	p.E478E	3
LARP1	COAD	chr5	154173389	154173390	-	C	Frame_Shift_Ins	p.A223fs	3
LARP1	UCEC	chr5	154174839	154174839	G	T	Missense_Mutation	p.R369L	3
LARP1	PAAD	chr5	154174798	154174798	T	C	Silent	p.A355A	3
LARP1	BRCA	chr5	154169889	154169890	CT	-	Frame_Shift_Del	p.S71fs	3
LARP1	PAAD	chr5	154172210	154172210	G	A	Missense_Mutation	p.R121H	3
LARP1	BRCA	chr5	154181757	154181757	A	T	Missense_Mutation	p.D559V	3
LARP1	PCPG	chr5	154183828	154183828	T	A	Missense_Mutation	p.M759K	2
LARP1	CESC	chr5	154179283	154179283	G	A	Missense_Mutation		2
LARP1	UCEC	chr5	154169883	154169883	A	G	Splice_Site	e2-2	2
LARP1	KIRP	chr5	154183178	154183178	T	A	Missense_Mutation		2
LARP1	UCEC	chr5	154179440	154179440	A	G	Silent	p.A441	2
LARP1	SKCM	chr5	154181850	154181850	C	T	Missense_Mutation	p.S590L	2
LARP1	STAD	chr5	154092575	154092575	C	T	Silent	p.G30G	2
LARP1	LUAD	chr5	154173389	154173390	-	C	Frame_Shift_Ins	p.P223fs	2
LARP1	STAD	chr5	154181659	154181659	G	A	Silent		2
LARP1	CESC	chr5	154185505	154185505	A	C	Missense_Mutation		2
LARP1	UCEC	chr5	154170210	154170210	T	C	Silent	p.G91	2
LARP1	UCEC	chr5	154179522	154179522	T	C	Missense_Mutation	p.S469P	2
LARP1	SKCM	chr5	154174820	154174820	C	T	Missense_Mutation	p.L363F	2
LARP1	SKCM	chr5	154092519	154092519	C	T	Missense_Mutation	p.P12S	2
LARP1	COAD	chr5	154185462	154185462	G	A	Silent	p.T779T	2
LARP1	UVM	chr5	154173236	154173236	G	A	Missense_Mutation		2
LARP1	SARC	chr5	154193507	154193507	G	A	Missense_Mutation		2
LARP1	STAD	chr5	154188143	154188143	G	T	Missense_Mutation		2
LARP1	CESC	chr5	154092620	154092620	G	A	Silent		2
LARP1	UCEC	chr5	154173213	154173213	G	A	Silent	p.E189	2
LARP1	UCEC	chr5	154181731	154181731	T	C	Silent	p.S550	2
LARP1	LIHC	chr5	154092569	154092569	C	-	Frame_Shift_Del	p.C28fs	2
LARP1	PRAD	chr5	154182914	154182914	C	A	Missense_Mutation	p.P648H	2
LARP1	SARC	chr5	154173718	154173718	G	A	Silent		2
LARP1	SKCM	chr5	154181828	154181828	G	C	Missense_Mutation	p.D583H	2
LARP1	STAD	chr5	154173546	154173546	G	-	Frame_Shift_Del	p.R275fs	2
LARP1	CESC	chr5	154173553	154173553	C	T	Silent		2
LARP1	UCEC	chr5	154173258	154173258	A	C	Silent	p.I204	2
LARP1	UCEC	chr5	154181809	154181809	G	A	Missense_Mutation	p.M576I	2
LARP1	LIHC	chr5	154092657	154092657	C	-	Frame_Shift_Del	p.P58fs	2
LARP1	PAAD	chr5	154172210	154172210	G	A	Missense_Mutation		2
LARP1	SKCM	chr5	154183798	154183798	C	T	Missense_Mutation	p.P749L	2
LARP1	SARC	chr5	154183802	154183802	C	T	Silent		2
LARP1	STAD	chr5	154188143	154188143	G	T	Missense_Mutation	p.E864D	2
LARP1	CESC	chr5	154188117	154188117	G	C	Missense_Mutation		2
LARP1	UCEC	chr5	154173269	154173269	G	A	Missense_Mutation	p.R208H	2
LARP1	UCEC	chr5	154183160	154183160	G	A	Missense_Mutation	p.R688H	2
LARP1	PAAD	chr5	154174798	154174798	T	C	Silent		2
LARP1	SARC	chr5	154191148	154191148	A	T	Missense_Mutation		2
LARP1	STAD	chr5	154181659	154181659	G	A	Silent	p.E526E	2
LARP1	CESC	chr5	154181657	154181657	G	C	Missense_Mutation		2
LARP1	UCEC	chr5	154173497	154173497	T	C	Missense_Mutation	p.S259P	2
LARP1	UCEC	chr5	154183836	154183836	C	T	Missense_Mutation	p.R762C	2
LARP1	PAAD	chr5	154179551	154179551	G	A	Silent		2
LARP1	KIRC	chr5	154183854	154183854	A	T	Missense_Mutation	p.T768S	2
LARP1	STAD	chr5	154173380	154173380	G	A	Missense_Mutation	p.V220M	2
LARP1	CESC	chr5	154179226	154179226	C	T	Missense_Mutation		2
LARP1	UCEC	chr5	154188092	154188092	A	G	Silent	p.R847	2
LARP1	STAD	chr5	154135745	154135745	C	-	Frame_Shift_Del	p.S143fs	2
LARP1	BRCA	chr5	154170243	154170243	T	C	Silent	p.P102	2
LARP1	SARC	chr5	154181828	154181828	G	T	Missense_Mutation	p.D583Y	2
LARP1	SKCM	chr5	154173508	154173508	C	T	Silent	p.G262G	2
LARP1	ACC	chr5	154173383	154173383	C	-	Frame_Shift_Del	p.V220fs	2
LARP1	CESC	chr5	154190876	154190876	C	G	Missense_Mutation		2
LARP1	UCEC	chr5	154174736	154174736	G	T	Nonsense_Mutation	p.E335*	2
LARP1	UCEC	chr5	154193632	154193632	G	A	Silent	p.S1012	2
LARP1	KIRC	chr5	154181821	154181822	-	G	Frame_Shift_Ins	p.PG580fs	2
LARP1	SKCM	chr5	154181779	154181779	C	T	Silent	p.I566I	2
LARP1	UCEC	chr5	154174769	154174769	G	T	Missense_Mutation	p.D346Y	2
LARP1	LIHC	chr5	154173763	154173763	C	G	Missense_Mutation		2
LARP1	STAD	chr5	154183217	154183217	G	A	Missense_Mutation		2
LARP1	THCA	chr5	154190917	154190918	-	-	Splice_Site		2
LARP1	UCEC	chr5	154135745	154135745	C	-	Frame_Shift_Del		2
LARP1	SARC	chr5	154181828	154181828	G	T	Missense_Mutation		2
LARP1	SARC	chr5	154193507	154193507	G	A	Missense_Mutation	p.G971S	2
LARP1	SKCM	chr5	154185574	154185574	C	T	Missense_Mutation	p.R817C	2
LARP1	ACC	chr5	154173385	154173390	CGTGGC	-	In_Frame_Del	p.221_223del	2
LARP1	UCEC	chr5	154179309	154179309	A	C	Missense_Mutation	p.Q435H	2
LARP1	PCPG	chr5	154183828	154183828	T	A	Missense_Mutation		2
LARP1	UCEC	chr5	154092552	154092552	G	A	Missense_Mutation	p.A23T	2
LARP1	HNSC	chr5	154179150	154179150	G	T	Splice_Site		2
LARP1	UCEC	chr5	154179434	154179434	G	A	Silent	p.E439	2
LARP1	LIHC	chr5	154173763	154173763	C	G	Missense_Mutation	p.S314R	2
LARP1	SARC	chr5	154191148	154191148	A	T	Missense_Mutation	p.K933I	2
LARP1	SKCM	chr5	154179196	154179196	C	T	Missense_Mutation	p.R398C	2
LARP1	SKCM	chr5	154190886	154190886	C	T	Nonsense_Mutation	p.Q898*	1
LARP1	STAD	chr5	154181920	154181920	G	A	Silent	p.L690L	1
LARP1	BLCA	chr5	154183259	154183259	C	T	Missense_Mutation	p.S721L	1
LARP1	HNSC	chr5	154179273	154179273	C	T	Silent	p.L500L	1
LARP1	LIHC	chr5	154172207	154172207	C	-	Frame_Shift_Del	p.T120fs	1
LARP1	LUAD	chr5	154173492	154173492	G	T	Missense_Mutation	p.R257L	1
LARP1	LUAD	chr5	154174747	154174747	C	G	Missense_Mutation	p.F338L	1
LARP1	SARC	chr5	154183810	154183810	G	T	Missense_Mutation		1
LARP1	STAD	chr5	154173380	154173380	G	A	Missense_Mutation		1
LARP1	THCA	chr5	154190917	154190918	-	T	Splice_Site	.	1
LARP1	DLBC	chr5	154092616	154092616	C	T	Missense_Mutation	p.A44V	1
LARP1	GBM	chr5	154188110	154188110	G	A	Silent		1
LARP1	HNSC	chr5	154173460	154173460	G	A	Silent		1
LARP1	LIHC	chr5	154172335	154172335	C	T	Nonsense_Mutation	p.R163X	1
LARP1	OV	chr5	154154929	154154929	G	A	Missense_Mutation		1
LARP1	SARC	chr5	154183117	154183117	G	T	Missense_Mutation		1
LARP1	BLCA	chr5	154173482	154173482	G	A	Missense_Mutation		1
LARP1	CESC	chr5	154179283	154179283	G	A	Missense_Mutation	p.E427K	1
LARP1	SKCM	chr5	154181827	154181827	G	A	Silent	p.G582G	1
LARP1	STAD	chr5	154181870	154181870	G	A	Missense_Mutation	p.E674K	1
LARP1	BLCA	chr5	154183239	154183239	C	G	Silent	p.L714L	1
LARP1	COAD	chr5	154183778	154183778	G	A	Silent	p.K742K	1
LARP1	HNSC	chr5	154183811	154183811	C	T	Silent	p.S830S	1
LARP1	LIHC	chr5	154179229	154179229	C	-	Frame_Shift_Del	p.P410fs	1
LARP1	LUAD	chr5	154191138	154191138	A	G	Missense_Mutation	p.I930V	1
LARP1	PRAD	chr5	154174848	154174848	C	T	Missense_Mutation	p.A372V	1
LARP1	SARC	chr5	154181865	154181865	G	T	Missense_Mutation		1
LARP1	ESCA	chr5	154173390	154173390	C	-	Frame_Shift_Del	p.T226fs	1
LARP1	GBM	chr5	154188112	154188112	T	A	Missense_Mutation		1
LARP1	LGG	chr5	154190842	154190842	A	G	Missense_Mutation	p.Y883C	1
LARP1	HNSC	chr5	154179521	154179521	G	T	Silent	p.L468L	1
LARP1	LIHC	chr5	154182951	154182952	-	G	Frame_Shift_Ins	p.A661fs	1
LARP1	OV	chr5	154182974	154182974	G	T	Splice_Site	p.V668_splice	1
LARP1	STAD	chr5	154173390	154173391	CC	-	Frame_Shift_Del	p.223_223del	1
LARP1	BLCA	chr5	154174850	154174850	C	G	Missense_Mutation		1
LARP1	CESC	chr5	154181657	154181657	G	C	Missense_Mutation	p.E526Q	1
LARP1	SKCM	chr5	154092526	154092526	C	T	Missense_Mutation	p.P14L	1
LARP1	STAD	chr5	154182861	154182861	G	T	Missense_Mutation	p.E707D	1
LARP1	BLCA	chr5	154173531	154173531	G	T	Missense_Mutation	p.G270V	1
LARP1	THYM	chr5	154092639	154092639	G	T	Missense_Mutation		1
LARP1	KICH	chr5	154173804	154173819	ACTACATCAAGCGCCA	-	Frame_Shift_Del		1
LARP1	LIHC	chr5	154188032	154188032	G	-	Frame_Shift_Del	p.L827fs	1
LARP1	LUAD	chr5	154172335	154172335	C	T	Nonsense_Mutation	p.R163*	1
LARP1	LUAD	chr5	154181811	154181811	G	T	Missense_Mutation	p.R654L	1
LARP1	GBM	chr5	154173274	154173274	G	T	Nonsense_Mutation		1
LARP1	LGG	chr5	154179587	154179587	C	T	Silent	p.S490S	1
LARP1	HNSC	chr5	154173460	154173460	G	A	Silent	p.S246S	1
LARP1	OV	chr5	154152528	154152529	-	A	Frame_Shift_Ins	p.R240fs	1
LARP1	SKCM	chr5	154193450	154193450	C	T	Missense_Mutation	p.P952S	1
LARP1	STAD	chr5	154179464	154179464	C	T	Silent	p.T449T	1
LARP1	BLCA	chr5	154181594	154181594	C	G	Missense_Mutation		1
LARP1	CESC	chr5	154185505	154185505	A	C	Missense_Mutation	p.K794Q	1
LARP1	SKCM	chr5	154092525	154092525	C	T	Missense_Mutation	p.P14S	1
LARP1	STAD	chr5	154183768	154183768	G	A	Missense_Mutation	p.R816Q	1
LARP1	BLCA	chr5	154179579	154179579	C	T	Missense_Mutation	p.R488W	1
LARP1	COAD	chr5	154185465	154185465	T	C	Silent	p.P780P	1
LARP1	THYM	chr5	154092639	154092639	G	T	Missense_Mutation	p.D52Y	1
LARP1	LUAD	chr5	154191175	154191175	G	A	Missense_Mutation	p.R942Q	1
LARP1	LUAD	chr5	154173449	154173449	G	C	Missense_Mutation	p.D243H	1
LARP1	LUAD	chr5	154181956	154181956	C	G	Missense_Mutation	p.I702M	1
LARP1	HNSC	chr5	154179521	154179521	G	T	Silent		1
LARP1	LGG	chr5	154172182	154172182	C	T	Splice_Site	p.P112_splice	1
LARP1	CESC	chr5	154092620	154092620	G	A	Silent	p.P45	1
LARP1	HNSC	chr5	154179561	154179561	G	T	Nonsense_Mutation	p.E482*	1
LARP1	SKCM	chr5	154173498	154173498	C	T	Missense_Mutation	p.S259F	1
LARP1	STAD	chr5	154183812	154183812	C	T	Missense_Mutation	p.H754Y	1
LARP1	BLCA	chr5	154183259	154183259	C	T	Missense_Mutation		1
LARP1	STAD	chr5	154173252	154173252	A	G	Silent	p.R279R	1
LARP1	BLCA	chr5	154181879	154181879	A	C	Missense_Mutation	p.K600Q	1
LARP1	COAD	chr5	154190830	154190830	G	A	Missense_Mutation	p.R879Q	1
LARP1	THYM	chr5	154173754	154173754	C	T	Silent		1
LARP1	KIRC	chr5	154181675	154181676	TT	-	Frame_Shift_Del	p.531_532del	1
LARP1	LUAD	chr5	154179189	154179189	G	C	Missense_Mutation	p.E395D	1
LARP1	PRAD	chr5	154173201	154173201	A	C	Missense_Mutation	p.E185D	1
LARP1	LUAD	chr5	154169891	154169891	C	T	Missense_Mutation	p.S148F	1
LARP1	SKCM	chr5	154190886	154190886	C	T	Nonsense_Mutation	p.Q898X	1
LARP1	ESCA	chr5	154173457	154173457	A	G	Silent		1
LARP1	HNSC	chr5	154179188	154179188	A	G	Missense_Mutation		1
LARP1	LGG	chr5	154172182	154172182	C	T	Missense_Mutation		1
LARP1	BLCA	chr5	154173531	154173531	G	T	Missense_Mutation		1
LARP1	CESC	chr5	154188117	154188117	G	C	Missense_Mutation	p.E856Q	1
LARP1	HNSC	chr5	154179273	154179273	C	T	Silent	p.L423L	1
LARP1	LUAD	chr5	154181811	154181811	G	T	Missense_Mutation	p.R577L	1
LARP1	SKCM	chr5	154190829	154190829	C	T	Nonsense_Mutation	p.R879*	1
LARP1	STAD	chr5	154183217	154183217	G	A	Missense_Mutation	p.R707H	1
LARP1	SKCM	chr5	154182949	154182949	C	T	Missense_Mutation	p.P660S	1
LARP1	STAD	chr5	154172187	154172187	G	A	Silent	p.Q190Q	1
LARP1	BLCA	chr5	154181594	154181594	C	G	Missense_Mutation	p.L582V	1
LARP1	COAD	chr5	154191081	154191081	T	C	Missense_Mutation	p.Y911H	1
LARP1	KIRC	chr5	154191178	154191185	GTCTTGAA	-	Frame_Shift_Del	p.943_945del	1
LARP1	LUAD	chr5	154182849	154182849	G	A	Splice_Site		1
LARP1	PRAD	chr5	154181820	154181820	C	A	Missense_Mutation	p.P580Q	1
LARP1	LUAD	chr5	154179189	154179189	G	C	Missense_Mutation	p.E472D	1
LARP1	SKCM	chr5	154190829	154190829	C	T	Nonsense_Mutation	p.R879X	1
LARP1	HNSC	chr5	154193517	154193517	G	T	Missense_Mutation		1
LARP1	LGG	chr5	154182953	154182953	G	T	Missense_Mutation		1
LARP1	BLCA	chr5	154179579	154179579	C	T	Missense_Mutation		1
LARP1	CESC	chr5	154190876	154190876	C	G	Missense_Mutation	p.F894L	1
LARP1	HNSC	chr5	154179306	154179306	C	T	Silent	p.Y434Y	1
LARP1	LUAD	chr5	154173195	154173195	G	T	Missense_Mutation	p.K183N	1
LARP1	SKCM	chr5	154173543	154173543	G	C	Missense_Mutation	p.G274A	1
LARP1	STAD	chr5	154179464	154179464	C	T	Silent	p.T526T	1
LARP1	SKCM	chr5	154183801	154183801	C	T	Missense_Mutation	p.P750L	1
LARP1	STAD	chr5	154183869	154183869	T	C	Splice_Site	p.S849_splice	1
LARP1	BLCA	chr5	154173531	154173531	G	T	Missense_Mutation	p.G347V	1
LARP1	COAD	chr5	154191114	154191114	T	G	Missense_Mutation	p.Y922D	1
LARP1	GBM	chr5	154169931	154169932	GC	-	Frame_Shift_Del	p.Q84fs	1
LARP1	LUAD	chr5	154183157	154183157	C	A	Missense_Mutation	p.A687D	1
LARP1	READ	chr5	154172313	154172313	G	A	Silent	p.K155K	1
LARP1	LUAD	chr5	154182849	154182849	G	A	Splice_Site	p.Q704_splice	1
LARP1	SARC	chr5	154183802	154183802	C	T	Silent	p.P750P	1
LARP1	SKCM	chr5	154185511	154185511	C	T	Nonsense_Mutation	p.Q796X	1
LARP1	HNSC	chr5	154179306	154179306	C	T	Silent		1
LARP1	LIHC	chr5	154174794	154174794	A	G	Missense_Mutation		1
LARP1	BLCA	chr5	154181879	154181879	A	C	Missense_Mutation		1
LARP1	CESC	chr5	154191164	154191164	C	T	Silent	p.L938	1
LARP1	HNSC	chr5	154193517	154193517	G	T	Missense_Mutation	p.R974M	1
LARP1	LIHC	chr5	154173399	154173399	C	-	Frame_Shift_Del	p.T226fs	1
LARP1	LUAD	chr5	154185566	154185566	A	G	Missense_Mutation	p.H814R	1
LARP1	SKCM	chr5	154092534	154092534	G	A	Missense_Mutation	p.E17K	1
LARP1	STAD	chr5	154183812	154183812	C	T	Missense_Mutation	p.H831Y	1
LARP1	SKCM	chr5	154188023	154188023	G	A	Silent	p.R824R	1
LARP1	GBM	chr5	154188110	154188110	G	A	Silent	p.K853K	1
LARP1	KIRC	chr5	154092627	154092627	G	A	Missense_Mutation	p.E48K	1
LARP1	LUAD	chr5	154188019	154188019	A	T	Splice_Site	p.E823_splice	1
LARP1	READ	chr5	154179551	154179551	G	T	Missense_Mutation	p.E478D	1
LARP1	LUAD	chr5	154188019	154188019	A	T	Missense_Mutation	p.E900V	1
LARP1	STAD	chr5	154172296	154172296	G	T	Nonsense_Mutation	p.E150X	1
LARP1	HNSC	chr5	154179273	154179273	C	T	Silent		1
LARP1	LIHC	chr5	154181822	154181822	G	-	Frame_Shift_Del		1
LARP1	BLCA	chr5	154173482	154173482	G	A	Missense_Mutation	p.G254S	1
LARP1	CHOL	chr5	154190824	154190824	T	C	Missense_Mutation	p.L877P	1
LARP1	HNSC	chr5	154179188	154179188	A	G	Missense_Mutation	p.E395G	1
LARP1	LIHC	chr5	154191111	154191111	A	-	Frame_Shift_Del	p.K921fs	1
LARP1	LUAD	chr5	154183274	154183274	T	A	Missense_Mutation	p.V726E	1
LARP1	SKCM	chr5	154185511	154185511	C	T	Nonsense_Mutation	p.Q796*	1
LARP1	STAD	chr5	154169932	154169932	C	T	Missense_Mutation	p.R162C	1
LARP1	SKCM	chr5	154173503	154173503	C	T	Missense_Mutation	p.R261C	1
LARP1	COAD	chr5	154179581	154179581	G	A	Silent	p.R488R	1
LARP1	GBM	chr5	154188112	154188112	T	A	Missense_Mutation	p.M854K	1
LARP1	UCEC	chr5	154183804	154183804	T	C	Missense_Mutation	p.L751S	1
LARP1	LUAD	chr5	154179525	154179525	G	C	Missense_Mutation	p.A470P	1
LARP1	READ	chr5	154181722	154181722	T	G	Silent	p.T547T	1
LARP1	LUSC	chr5	154169899	154169899	G	A	Missense_Mutation	p.A74T	1
LARP1	SARC	chr5	154173718	154173718	G	A	Silent	p.T299T	1
LARP1	STAD	chr5	154173252	154173252	A	G	Silent	p.R202R	1
LARP1	CESC	chr5	154092620	154092620	G	A	Silent	p.P45P	1
LARP1	HNSC	chr5	154173241	154173241	C	T	Missense_Mutation		1
LARP1	BLCA	chr5	154174850	154174850	C	G	Missense_Mutation	p.L373V	1
LARP1	COAD	chr5	154173478	154173478	G	C	Silent	p.G252G	1
LARP1	HNSC	chr5	154179561	154179561	G	T	Nonsense_Mutation	p.E559*	1
LARP1	UCS	chr5	154179268	154179268	C	T	Missense_Mutation		1
LARP1	LIHC	chr5	154092673	154092673	C	-	Frame_Shift_Del	p.A63fs	1
LARP1	LUAD	chr5	154181956	154181956	C	G	Missense_Mutation	p.I625M	1
LARP1	SKCM	chr5	154173713	154173713	C	T	Missense_Mutation	p.R298C	1
LARP1	STAD	chr5	154185462	154185462	G	A	Silent	p.T856T	1
LARP1	COAD	chr5	154188055	154188055	T	C	Missense_Mutation	p.M835T	1
LARP1	GBM	chr5	154135677	154135677	C	T	Silent		1
LARP1	KIRC	chr5	154191178	154191185	GTCTTGAA	-	Frame_Shift_Del	p.RLE943fs	1
LARP1	LUAD	chr5	154172338	154172338	G	T	Missense_Mutation	p.G164C	1
LARP1	LIHC	chr5	154191172	154191172	T	C	Missense_Mutation		1
LARP1	MESO	chr5	154181792	154181792	C	A	Missense_Mutation		1
LARP1	STAD	chr5	154172187	154172187	G	A	Silent	p.Q113Q	1
LARP1	CESC	chr5	154191164	154191164	C	T	Silent		1
LARP1	HNSC	chr5	154173242	154173242	C	T	Missense_Mutation		1
LARP1	SKCM	chr5	154193632	154193632	G	A	Silent	p.S1012S	1
LARP1	STAD	chr5	154172296	154172296	G	T	Nonsense_Mutation	p.E227*	1
LARP1	BLCA	chr5	154181594	154181594	C	G	Missense_Mutation	p.L505V	1
LARP1	COAD	chr5	154181566	154181566	G	T	Splice_Site	.	1
LARP1	HNSC	chr5	154179306	154179306	C	T	Silent	p.Y511Y	1
LARP1	UCS	chr5	154183841	154183841	G	T	Missense_Mutation		1
LARP1	LIHC	chr5	154172257	154172257	G	-	Frame_Shift_Del	p.G137fs	1
LARP1	LUAD	chr5	154169891	154169891	C	T	Missense_Mutation	p.S71F	1
LARP1	LUAD	chr5	154185581	154185581	G	A	Missense_Mutation	p.R819H	1
LARP1	SARC	chr5	154188028	154188028	G	T	Missense_Mutation		1
LARP1	STAD	chr5	154173546	154173546	G	-	Frame_Shift_Del		1
LARP1	THCA	chr5	154172209	154172209	C	A	Missense_Mutation		1
LARP1	DLBC	chr5	154179585	154179585	T	C	Missense_Mutation	p.S490P	1
LARP1	GBM	chr5	154193504	154193504	G	A	Missense_Mutation	p.G970S	1
LARP1	OV	chr5	154162068	154162069	-	GAT	In_Frame_Ins		1
LARP1	STAD	chr5	154182861	154182861	G	T	Missense_Mutation	p.E630D	1
LARP1	ACC	chr5	154173383	154173383	C	-	Frame_Shift_Del	p.P221fs	1
LARP1	CESC	chr5	154179226	154179226	C	T	Missense_Mutation	p.L408F	1

Copy number variation (CNV) of LARP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across LARP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
83043	N/A	AK057839	CST3	chr20	23608717	+	LARP1	chr5	154194531	+
83043	BLCA	TCGA-4Z-AA84-01A	CTNNA1	chr5	138088860	-	LARP1	chr5	154190807	+
83043	BLCA	TCGA-4Z-AA84-01A	CTNNA1	chr5	138089199	+	LARP1	chr5	154190807	+
83043	N/A	BM841980	EPB41L2	chr6	131277558	-	LARP1	chr5	154196355	+
83043	STAD	TCGA-BR-A4J5-01A	IER2	chr19	13261366	+	LARP1	chr5	154169885	+
88875	Non-Cancer	2397N	LARP1	chr5	154191200	+	CNOT8	chr5	154244751	+
99820	N/A	CB054408	LARP1	chr5	154085854	-	FAM168A	chr11	73111837	+
101960	KIRC	TCGA-BP-4972-01A	LARP1	chr5	154194908	+	FTL	chr19	49468820	+
101285	N/A	BF841958	LARP1	chr5	154196201	+	HIRA	chr22	19338921	-
98098	LGG	TCGA-E1-A7Z4-01A	LARP1	chr5	154135753	+	MAFF	chr22	38609830	+
95549	N/A	U28727	LARP1	chr5	154194517	-	PAPPA	chr9	118916083	+
94778	N/A	AW968612	LARP1	chr5	154194294	-	PKD2	chr4	88933898	-
83043	CESC	TCGA-JW-A5VL-01A	NDRG1	chr8	134249419	-	LARP1	chr5	154188019	+
83043	N/A	AI636681	SAMD14	chr17	48191603	+	LARP1	chr5	154182544	-
83044	STAD	TCGA-B7-A5TJ	SLC36A1	chr5	150827374	+	LARP1	chr5	154169884	+

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LAML	LARP1	0.496572305841201	-0.700026174999987	0.000224680502859633	0.000173347629609063	0.000228067263757277	160
LGG	LARP1	1.81263362831866	0.594780830997983	0.00908548117690236	0.00871817803573498	0.00964212634440862	525
SKCM	LARP1	0.793838626683278	-0.230875079344292	0.0330329714242113	0.0360838609098599	0.0332387715816626	462
SKCM	LARP1	0.793838626683278	-0.230875079344292	0.0330329714242113	0.0360838609098599	0.0332387715816626	462
KIRC	LARP1	0.75015814381462	-0.287471236259799	0.0482409156524011	0.0483266563164134	0.0488377556725647	604
KIRC	LARP1	0.75015814381462	-0.287471236259799	0.0482409156524011	0.0483266563164134	0.0488377556725647	604

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	LARP1	0.000279732781234576	0.0078
TGCT	LARP1	0.00190093665588587	0.051
HNSC	LARP1	0.00755048119462928	0.2
READ	LARP1	0.0138714346866052	0.35
MESO	LARP1	0.0230013402712388	0.55

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	LARP1	0.000714077634083452	0.024
PRAD	LARP1	0.0242119256301562	0.73
OV	LARP1	0.0167762218736572	0.52
THYM	LARP1	0.00730191271670917	0.23
HNSC	LARP1	0.0467796982040115	1

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source