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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GAPDH (NCBI Gene ID:2597)

Gene Summary

Gene Summary

Gene Information	Gene Name: GAPDH
	Gene ID: 2597
	Gene Symbol	GAPDH
	Gene ID	2597
	Gene Name	glyceraldehyde-3-phosphate dehydrogenase
	Synonyms	G3PD\|GAPD\|HEL-S-162eP
	Cytomap	12p13.31
	Type of Gene	protein-coding
	Description	glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH
	Modification date	20200327
	UniProtAcc	P04406

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GAPDH	GO:0010951	negative regulation of endopeptidase activity	22832495
Hgene	GAPDH	GO:0017148	negative regulation of translation	23071094
Hgene	GAPDH	GO:0031640	killing of cells of other organism	22832495
Hgene	GAPDH	GO:0050715	positive regulation of cytokine secretion	22832495
Hgene	GAPDH	GO:0050832	defense response to fungus	22832495
Hgene	GAPDH	GO:0051873	killing by host of symbiont cells	22832495
Hgene	GAPDH	GO:0052501	positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction	22832495
Hgene	GAPDH	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	22832495
Hgene	GAPDH	GO:0071346	cellular response to interferon-gamma	15479637

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
GAPDH	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'GAPDH[title] AND translation [title] AND human.'

Gene	Title	PMID
GAPDH	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000229239	6645849	6645956	Frame-shift
ENST00000396859	6645849	6645956	Frame-shift
ENST00000396861	6645849	6645956	Frame-shift
ENST00000229239	6646266	6646382	Frame-shift
ENST00000396859	6646266	6646382	Frame-shift
ENST00000396861	6646266	6646382	Frame-shift
ENST00000229239	6646474	6646556	Frame-shift
ENST00000396859	6646474	6646556	Frame-shift
ENST00000396861	6646474	6646556	Frame-shift
ENST00000229239	6646749	6647162	Frame-shift
ENST00000396859	6646749	6647162	Frame-shift
ENST00000396861	6646749	6647162	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	GAPDH	-3.07354785261475	0.02734375
BRCA	GAPDH	-1.37642902567885	1.15182974050406e-18
LUAD	GAPDH	-2.39625242862964	7.0750762948169e-11

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GAPDH (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BLCA	Cell metabolism gene	GAPDH	TPI1	0.804263022	7.12E-98
BRCA	Cell metabolism gene	GAPDH	TPI1	0.877020957	0
CESC	Cell metabolism gene	GAPDH	TPI1	0.828830935	3.68E-79
COAD	Cell metabolism gene	GAPDH	TPI1	0.804233409	6.94E-76
DLBC	Cell metabolism gene	GAPDH	CCT7	0.805349754	5.14E-12
DLBC	Cell metabolism gene	GAPDH	NME2	0.810270265	3.02E-12
DLBC	Cell metabolism gene	GAPDH	SNRPD3	0.810918057	2.81E-12
DLBC	Cell metabolism gene	GAPDH	TIMM13	0.813401324	2.14E-12
DLBC	Cell metabolism gene	GAPDH	PSMC3	0.815567633	1.67E-12
DLBC	Cell metabolism gene	GAPDH	SNRPB	0.846689205	3.41E-14
DLBC	Cell metabolism gene	GAPDH	MIF	0.857337288	7.34E-15
DLBC	Cell metabolism gene	GAPDH	TPI1	0.922707305	1.14E-20
DLBC	Epifactor	GAPDH	ANP32B	0.81236626	2.40E-12
DLBC	IUPHAR	GAPDH	SLC25A3	0.876375349	3.37E-16
DLBC	TF	GAPDH	NME2	0.810270265	3.02E-12
ESCA	Cell metabolism gene	GAPDH	TPI1	0.86830239	5.59E-61
GBM	Cell metabolism gene	GAPDH	TPI1	0.865502111	6.40E-53
HNSC	Cell metabolism gene	GAPDH	TPI1	0.856287034	5.82E-164
LUAD	Cell metabolism gene	GAPDH	TPI1	0.890149317	4.34E-198
LUSC	Cell metabolism gene	GAPDH	TPI1	0.9187761	1.44E-224
MESO	Cell metabolism gene	GAPDH	TPI1	0.82460719	9.72E-23
OV	Cell metabolism gene	GAPDH	TPI1	0.849387436	6.27E-87
PAAD	Cell metabolism gene	GAPDH	TPI1	0.937194761	1.02E-84
PRAD	Cell metabolism gene	GAPDH	TPI1	0.828934796	2.20E-140
SKCM	Cell metabolism gene	GAPDH	TPI1	0.812585105	9.88E-113
STAD	Cell metabolism gene	GAPDH	TPI1	0.815063758	2.95E-108
TGCT	Cell metabolism gene	GAPDH	TPI1	0.880145719	1.07E-51
THYM	Cell metabolism gene	GAPDH	PSMA5	0.800020398	2.15E-28
THYM	Cell metabolism gene	GAPDH	COX17	0.801045872	1.63E-28
THYM	Cell metabolism gene	GAPDH	GEMIN7	0.802737526	1.03E-28
THYM	Cell metabolism gene	GAPDH	GALK1	0.80567312	4.61E-29
THYM	Cell metabolism gene	GAPDH	NT5M	0.805694389	4.58E-29
THYM	Cell metabolism gene	GAPDH	AK2	0.805873672	4.36E-29
THYM	Cell metabolism gene	GAPDH	TOMM22	0.807077519	3.12E-29
THYM	Cell metabolism gene	GAPDH	WBSCR22	0.807965609	2.43E-29
THYM	Cell metabolism gene	GAPDH	HMBS	0.810450974	1.21E-29
THYM	Cell metabolism gene	GAPDH	GRPEL1	0.810754131	1.11E-29
THYM	Cell metabolism gene	GAPDH	ACOT8	0.811237113	9.64E-30
THYM	Cell metabolism gene	GAPDH	PSMD13	0.812008175	7.73E-30
THYM	Cell metabolism gene	GAPDH	POLA2	0.812724284	6.29E-30
THYM	Cell metabolism gene	GAPDH	DGUOK	0.814140873	4.17E-30
THYM	Cell metabolism gene	GAPDH	PCYT2	0.815599886	2.72E-30
THYM	Cell metabolism gene	GAPDH	SNRPF	0.815820973	2.55E-30
THYM	Cell metabolism gene	GAPDH	PSMB7	0.816516565	2.08E-30
THYM	Cell metabolism gene	GAPDH	DUT	0.818019135	1.33E-30
THYM	Cell metabolism gene	GAPDH	SRM	0.818096235	1.30E-30
THYM	Cell metabolism gene	GAPDH	PSMC3	0.818116067	1.29E-30
THYM	Cell metabolism gene	GAPDH	CCT3	0.820211477	6.90E-31
THYM	Cell metabolism gene	GAPDH	NANS	0.820254276	6.81E-31
THYM	Cell metabolism gene	GAPDH	TIMM8B	0.821338644	4.90E-31
THYM	Cell metabolism gene	GAPDH	ANP32A	0.823444842	2.57E-31
THYM	Cell metabolism gene	GAPDH	PSMB4	0.825583948	1.33E-31
THYM	Cell metabolism gene	GAPDH	TXN	0.826600427	9.64E-32
THYM	Cell metabolism gene	GAPDH	EXOSC1	0.829188538	4.24E-32
THYM	Cell metabolism gene	GAPDH	POLR3K	0.831971152	1.73E-32
THYM	Cell metabolism gene	GAPDH	PSMD4	0.832565753	1.42E-32
THYM	Cell metabolism gene	GAPDH	BDH1	0.832594231	1.41E-32
THYM	Cell metabolism gene	GAPDH	SNRPG	0.833178149	1.17E-32
THYM	Cell metabolism gene	GAPDH	TUBA1C	0.833705273	9.80E-33
THYM	Cell metabolism gene	GAPDH	POLR2H	0.83675001	3.56E-33
THYM	Cell metabolism gene	GAPDH	SNRPD2	0.836835968	3.46E-33
THYM	Cell metabolism gene	GAPDH	POLD1	0.837124597	3.14E-33
THYM	Cell metabolism gene	GAPDH	TKT	0.838438326	2.01E-33
THYM	Cell metabolism gene	GAPDH	SEC61G	0.839749048	1.29E-33
THYM	Cell metabolism gene	GAPDH	LSM3	0.840130155	1.13E-33
THYM	Cell metabolism gene	GAPDH	SNRPD1	0.840402974	1.03E-33
THYM	Cell metabolism gene	GAPDH	PSMB3	0.840919432	8.60E-34
THYM	Cell metabolism gene	GAPDH	GEMIN6	0.841838342	6.25E-34
THYM	Cell metabolism gene	GAPDH	NME1	0.847831041	7.43E-35
THYM	Cell metabolism gene	GAPDH	IDH2	0.848057302	6.84E-35
THYM	Cell metabolism gene	GAPDH	PSMB2	0.848180387	6.55E-35
THYM	Cell metabolism gene	GAPDH	PREB	0.848651933	5.51E-35
THYM	Cell metabolism gene	GAPDH	PSMA4	0.849710419	3.74E-35
THYM	Cell metabolism gene	GAPDH	PHKG2	0.850712639	2.58E-35
THYM	Cell metabolism gene	GAPDH	NOP56	0.85628539	3.14E-36
THYM	Cell metabolism gene	GAPDH	LSM5	0.858095904	1.55E-36
THYM	Cell metabolism gene	GAPDH	SNRPE	0.862163867	3.07E-37
THYM	Cell metabolism gene	GAPDH	SNRPB	0.862171637	3.06E-37
THYM	Cell metabolism gene	GAPDH	TIMM17B	0.862692726	2.48E-37
THYM	Cell metabolism gene	GAPDH	PGP	0.862831611	2.34E-37
THYM	Cell metabolism gene	GAPDH	TK1	0.863329147	1.91E-37
THYM	Cell metabolism gene	GAPDH	TOMM40	0.865087248	9.30E-38
THYM	Cell metabolism gene	GAPDH	PSMA6	0.870140897	1.10E-38
THYM	Cell metabolism gene	GAPDH	TOMM5	0.880723176	9.30E-41
THYM	Cell metabolism gene	GAPDH	TSTA3	0.884569875	1.46E-41
THYM	Cell metabolism gene	GAPDH	LSM4	0.889039491	1.57E-42
THYM	Cell metabolism gene	GAPDH	EBP	0.889084376	1.54E-42
THYM	Cell metabolism gene	GAPDH	DTYMK	0.890131161	8.98E-43
THYM	Cell metabolism gene	GAPDH	ATIC	0.893368616	1.65E-43
THYM	Cell metabolism gene	GAPDH	PAFAH1B3	0.911478652	4.04E-48
THYM	CGC	GAPDH	SDHAF2	0.817496694	1.56E-30
THYM	CGC	GAPDH	FEN1	0.833066009	1.21E-32
THYM	CGC	GAPDH	POLD1	0.837124597	3.14E-33
THYM	CGC	GAPDH	BCL2L12	0.838336343	2.08E-33
THYM	CGC	GAPDH	IDH2	0.848057302	6.84E-35
THYM	CGC	GAPDH	COX6C	0.86388181	1.53E-37
THYM	CGC	GAPDH	FANCG	0.86559351	7.54E-38
THYM	CGC	GAPDH	ATIC	0.893368616	1.65E-43
THYM	CGC	GAPDH	RECQL4	0.899870512	4.61E-45
THYM	Epifactor	GAPDH	TAF10	0.804635185	6.14E-29
THYM	Epifactor	GAPDH	RUVBL1	0.805807406	4.44E-29
THYM	Epifactor	GAPDH	HIST1H2AJ	0.806725015	3.44E-29
THYM	Epifactor	GAPDH	AURKB	0.806835316	3.34E-29
THYM	Epifactor	GAPDH	HDGF	0.808926266	1.86E-29
THYM	Epifactor	GAPDH	CHRAC1	0.815204023	3.06E-30
THYM	Epifactor	GAPDH	H2AFZ	0.816097994	2.35E-30
THYM	Epifactor	GAPDH	ANP32A	0.823444842	2.57E-31
THYM	Epifactor	GAPDH	HIST1H2BH	0.825810594	1.23E-31
THYM	Epifactor	GAPDH	MAZ	0.826619083	9.58E-32
THYM	Epifactor	GAPDH	UBE2T	0.827463437	7.34E-32
THYM	Epifactor	GAPDH	HIST2H2AC	0.827983511	6.23E-32
THYM	Epifactor	GAPDH	SIRT7	0.828876371	4.69E-32
THYM	Epifactor	GAPDH	EXOSC1	0.829188538	4.24E-32
THYM	Epifactor	GAPDH	PPP4C	0.830812941	2.52E-32
THYM	Epifactor	GAPDH	ENY2	0.830903075	2.45E-32
THYM	Epifactor	GAPDH	RUVBL2	0.833481706	1.06E-32
THYM	Epifactor	GAPDH	BRMS1	0.838084843	2.27E-33
THYM	Epifactor	GAPDH	H2AFX	0.838115269	2.25E-33
THYM	Epifactor	GAPDH	VPS72	0.848928148	4.98E-35
THYM	Epifactor	GAPDH	SUV39H1	0.857122759	2.27E-36
THYM	Epifactor	GAPDH	NAP1L4	0.867753899	3.05E-38
THYM	Epifactor	GAPDH	CDK5	0.894381269	9.58E-44
THYM	Epifactor	GAPDH	PPM1G	0.899430189	5.92E-45
THYM	IUPHAR	GAPDH	PKMYT1	0.800558724	1.86E-28
THYM	IUPHAR	GAPDH	NT5M	0.805694389	4.58E-29
THYM	IUPHAR	GAPDH	AURKB	0.806835316	3.34E-29
THYM	IUPHAR	GAPDH	LETM1	0.815221435	3.04E-30
THYM	IUPHAR	GAPDH	UCHL3	0.821163166	5.17E-31
THYM	IUPHAR	GAPDH	SIRT7	0.828876371	4.69E-32
THYM	IUPHAR	GAPDH	TOP1MT	0.829274716	4.13E-32
THYM	IUPHAR	GAPDH	MTCH2	0.831383007	2.09E-32
THYM	IUPHAR	GAPDH	PPIA	0.844558831	2.40E-34
THYM	IUPHAR	GAPDH	IDH2	0.848057302	6.84E-35
THYM	IUPHAR	GAPDH	PSMB2	0.848180387	6.55E-35
THYM	IUPHAR	GAPDH	PHKG2	0.850712639	2.58E-35
THYM	IUPHAR	GAPDH	BIRC5	0.852397076	1.38E-35
THYM	IUPHAR	GAPDH	SUV39H1	0.857122759	2.27E-36
THYM	IUPHAR	GAPDH	ECE2	0.879408304	1.72E-40
THYM	IUPHAR	GAPDH	CDK5	0.894381269	9.58E-44
THYM	Kinase	GAPDH	PKMYT1	0.800558724	1.86E-28
THYM	Kinase	GAPDH	AURKB	0.806835316	3.34E-29
THYM	Kinase	GAPDH	PHKG2	0.850712639	2.58E-35
THYM	Kinase	GAPDH	CDK5	0.894381269	9.58E-44
THYM	TF	GAPDH	ETV2	0.801700179	1.37E-28
THYM	TF	GAPDH	ZNF444	0.81355319	4.95E-30
THYM	TF	GAPDH	PIN1	0.816331241	2.20E-30
THYM	TF	GAPDH	ZNF668	0.82055465	6.22E-31
THYM	TF	GAPDH	MYBL2	0.820831435	5.72E-31
THYM	TF	GAPDH	MAZ	0.826619083	9.58E-32
THYM	TF	GAPDH	MXD3	0.826894312	8.79E-32
THYM	TF	GAPDH	ZNF672	0.845804022	1.54E-34
THYM	TF	GAPDH	E2F1	0.847697353	7.80E-35
THYM	TF	GAPDH	PREB	0.848651933	5.51E-35
THYM	TF	GAPDH	MYPOP	0.852029997	1.58E-35
THYM	TF	GAPDH	USF1	0.863809251	1.57E-37
THYM	TF	GAPDH	GTF3A	0.881646381	6.00E-41
THYM	TSG	GAPDH	PIN1	0.816331241	2.20E-30
THYM	TSG	GAPDH	ZNF668	0.82055465	6.22E-31
THYM	TSG	GAPDH	ANP32A	0.823444842	2.57E-31
THYM	TSG	GAPDH	RAD51C	0.826766539	9.15E-32
THYM	TSG	GAPDH	BRMS1	0.838084843	2.27E-33
THYM	TSG	GAPDH	H2AFX	0.838115269	2.25E-33
THYM	TSG	GAPDH	E2F1	0.847697353	7.80E-35
THYM	TSG	GAPDH	NME1	0.847831041	7.43E-35
THYM	TSG	GAPDH	MYO1A	0.857379921	2.05E-36
THYM	TSG	GAPDH	FANCG	0.86559351	7.54E-38
UCEC	Cell metabolism gene	GAPDH	TPI1	0.867153586	3.71E-62
UCS	Cell metabolism gene	GAPDH	PSMA5	0.800020398	2.15E-28
UCS	Cell metabolism gene	GAPDH	COX17	0.801045872	1.63E-28
UCS	Cell metabolism gene	GAPDH	GEMIN7	0.802737526	1.03E-28
UCS	Cell metabolism gene	GAPDH	GALK1	0.80567312	4.61E-29
UCS	Cell metabolism gene	GAPDH	NT5M	0.805694389	4.58E-29
UCS	Cell metabolism gene	GAPDH	AK2	0.805873672	4.36E-29
UCS	Cell metabolism gene	GAPDH	TOMM22	0.807077519	3.12E-29
UCS	Cell metabolism gene	GAPDH	WBSCR22	0.807965609	2.43E-29
UCS	Cell metabolism gene	GAPDH	HMBS	0.810450974	1.21E-29
UCS	Cell metabolism gene	GAPDH	GRPEL1	0.810754131	1.11E-29
UCS	Cell metabolism gene	GAPDH	ACOT8	0.811237113	9.64E-30
UCS	Cell metabolism gene	GAPDH	PSMD13	0.812008175	7.73E-30
UCS	Cell metabolism gene	GAPDH	POLA2	0.812724284	6.29E-30
UCS	Cell metabolism gene	GAPDH	DGUOK	0.814140873	4.17E-30
UCS	Cell metabolism gene	GAPDH	PCYT2	0.815599886	2.72E-30
UCS	Cell metabolism gene	GAPDH	SNRPF	0.815820973	2.55E-30
UCS	Cell metabolism gene	GAPDH	PSMB7	0.816516565	2.08E-30
UCS	Cell metabolism gene	GAPDH	DUT	0.818019135	1.33E-30
UCS	Cell metabolism gene	GAPDH	SRM	0.818096235	1.30E-30
UCS	Cell metabolism gene	GAPDH	PSMC3	0.818116067	1.29E-30
UCS	Cell metabolism gene	GAPDH	CCT3	0.820211477	6.90E-31
UCS	Cell metabolism gene	GAPDH	NANS	0.820254276	6.81E-31
UCS	Cell metabolism gene	GAPDH	TIMM8B	0.821338644	4.90E-31
UCS	Cell metabolism gene	GAPDH	ANP32A	0.823444842	2.57E-31
UCS	Cell metabolism gene	GAPDH	PSMB4	0.825583948	1.33E-31
UCS	Cell metabolism gene	GAPDH	TXN	0.826600427	9.64E-32
UCS	Cell metabolism gene	GAPDH	EXOSC1	0.829188538	4.24E-32
UCS	Cell metabolism gene	GAPDH	POLR3K	0.831971152	1.73E-32
UCS	Cell metabolism gene	GAPDH	PSMD4	0.832565753	1.42E-32
UCS	Cell metabolism gene	GAPDH	BDH1	0.832594231	1.41E-32
UCS	Cell metabolism gene	GAPDH	SNRPG	0.833178149	1.17E-32
UCS	Cell metabolism gene	GAPDH	TUBA1C	0.833705273	9.80E-33
UCS	Cell metabolism gene	GAPDH	POLR2H	0.83675001	3.56E-33
UCS	Cell metabolism gene	GAPDH	SNRPD2	0.836835968	3.46E-33
UCS	Cell metabolism gene	GAPDH	POLD1	0.837124597	3.14E-33
UCS	Cell metabolism gene	GAPDH	TKT	0.838438326	2.01E-33
UCS	Cell metabolism gene	GAPDH	SEC61G	0.839749048	1.29E-33
UCS	Cell metabolism gene	GAPDH	LSM3	0.840130155	1.13E-33
UCS	Cell metabolism gene	GAPDH	SNRPD1	0.840402974	1.03E-33
UCS	Cell metabolism gene	GAPDH	PSMB3	0.840919432	8.60E-34
UCS	Cell metabolism gene	GAPDH	GEMIN6	0.841838342	6.25E-34
UCS	Cell metabolism gene	GAPDH	NME1	0.847831041	7.43E-35
UCS	Cell metabolism gene	GAPDH	IDH2	0.848057302	6.84E-35
UCS	Cell metabolism gene	GAPDH	PSMB2	0.848180387	6.55E-35
UCS	Cell metabolism gene	GAPDH	PREB	0.848651933	5.51E-35
UCS	Cell metabolism gene	GAPDH	PSMA4	0.849710419	3.74E-35
UCS	Cell metabolism gene	GAPDH	PHKG2	0.850712639	2.58E-35
UCS	Cell metabolism gene	GAPDH	NOP56	0.85628539	3.14E-36
UCS	Cell metabolism gene	GAPDH	LSM5	0.858095904	1.55E-36
UCS	Cell metabolism gene	GAPDH	SNRPE	0.862163867	3.07E-37
UCS	Cell metabolism gene	GAPDH	SNRPB	0.862171637	3.06E-37
UCS	Cell metabolism gene	GAPDH	TIMM17B	0.862692726	2.48E-37
UCS	Cell metabolism gene	GAPDH	PGP	0.862831611	2.34E-37
UCS	Cell metabolism gene	GAPDH	TK1	0.863329147	1.91E-37
UCS	Cell metabolism gene	GAPDH	TOMM40	0.865087248	9.30E-38
UCS	Cell metabolism gene	GAPDH	PSMA6	0.870140897	1.10E-38
UCS	Cell metabolism gene	GAPDH	TOMM5	0.880723176	9.30E-41
UCS	Cell metabolism gene	GAPDH	TSTA3	0.884569875	1.46E-41
UCS	Cell metabolism gene	GAPDH	LSM4	0.889039491	1.57E-42
UCS	Cell metabolism gene	GAPDH	EBP	0.889084376	1.54E-42
UCS	Cell metabolism gene	GAPDH	DTYMK	0.890131161	8.98E-43
UCS	Cell metabolism gene	GAPDH	ATIC	0.893368616	1.65E-43
UCS	Cell metabolism gene	GAPDH	PAFAH1B3	0.911478652	4.04E-48
UCS	CGC	GAPDH	SDHAF2	0.817496694	1.56E-30
UCS	CGC	GAPDH	FEN1	0.833066009	1.21E-32
UCS	CGC	GAPDH	POLD1	0.837124597	3.14E-33
UCS	CGC	GAPDH	BCL2L12	0.838336343	2.08E-33
UCS	CGC	GAPDH	IDH2	0.848057302	6.84E-35
UCS	CGC	GAPDH	COX6C	0.86388181	1.53E-37
UCS	CGC	GAPDH	FANCG	0.86559351	7.54E-38
UCS	CGC	GAPDH	ATIC	0.893368616	1.65E-43
UCS	CGC	GAPDH	RECQL4	0.899870512	4.61E-45
UCS	Epifactor	GAPDH	TAF10	0.804635185	6.14E-29
UCS	Epifactor	GAPDH	RUVBL1	0.805807406	4.44E-29
UCS	Epifactor	GAPDH	HIST1H2AJ	0.806725015	3.44E-29
UCS	Epifactor	GAPDH	AURKB	0.806835316	3.34E-29
UCS	Epifactor	GAPDH	HDGF	0.808926266	1.86E-29
UCS	Epifactor	GAPDH	CHRAC1	0.815204023	3.06E-30
UCS	Epifactor	GAPDH	H2AFZ	0.816097994	2.35E-30
UCS	Epifactor	GAPDH	ANP32A	0.823444842	2.57E-31
UCS	Epifactor	GAPDH	HIST1H2BH	0.825810594	1.23E-31
UCS	Epifactor	GAPDH	MAZ	0.826619083	9.58E-32
UCS	Epifactor	GAPDH	UBE2T	0.827463437	7.34E-32
UCS	Epifactor	GAPDH	HIST2H2AC	0.827983511	6.23E-32
UCS	Epifactor	GAPDH	SIRT7	0.828876371	4.69E-32
UCS	Epifactor	GAPDH	EXOSC1	0.829188538	4.24E-32
UCS	Epifactor	GAPDH	PPP4C	0.830812941	2.52E-32
UCS	Epifactor	GAPDH	ENY2	0.830903075	2.45E-32
UCS	Epifactor	GAPDH	RUVBL2	0.833481706	1.06E-32
UCS	Epifactor	GAPDH	BRMS1	0.838084843	2.27E-33
UCS	Epifactor	GAPDH	H2AFX	0.838115269	2.25E-33
UCS	Epifactor	GAPDH	VPS72	0.848928148	4.98E-35
UCS	Epifactor	GAPDH	SUV39H1	0.857122759	2.27E-36
UCS	Epifactor	GAPDH	NAP1L4	0.867753899	3.05E-38
UCS	Epifactor	GAPDH	CDK5	0.894381269	9.58E-44
UCS	Epifactor	GAPDH	PPM1G	0.899430189	5.92E-45
UCS	IUPHAR	GAPDH	PKMYT1	0.800558724	1.86E-28
UCS	IUPHAR	GAPDH	NT5M	0.805694389	4.58E-29
UCS	IUPHAR	GAPDH	AURKB	0.806835316	3.34E-29
UCS	IUPHAR	GAPDH	LETM1	0.815221435	3.04E-30
UCS	IUPHAR	GAPDH	UCHL3	0.821163166	5.17E-31
UCS	IUPHAR	GAPDH	SIRT7	0.828876371	4.69E-32
UCS	IUPHAR	GAPDH	TOP1MT	0.829274716	4.13E-32
UCS	IUPHAR	GAPDH	MTCH2	0.831383007	2.09E-32
UCS	IUPHAR	GAPDH	PPIA	0.844558831	2.40E-34
UCS	IUPHAR	GAPDH	IDH2	0.848057302	6.84E-35
UCS	IUPHAR	GAPDH	PSMB2	0.848180387	6.55E-35
UCS	IUPHAR	GAPDH	PHKG2	0.850712639	2.58E-35
UCS	IUPHAR	GAPDH	BIRC5	0.852397076	1.38E-35
UCS	IUPHAR	GAPDH	SUV39H1	0.857122759	2.27E-36
UCS	IUPHAR	GAPDH	ECE2	0.879408304	1.72E-40
UCS	IUPHAR	GAPDH	CDK5	0.894381269	9.58E-44
UCS	Kinase	GAPDH	PKMYT1	0.800558724	1.86E-28
UCS	Kinase	GAPDH	AURKB	0.806835316	3.34E-29
UCS	Kinase	GAPDH	PHKG2	0.850712639	2.58E-35
UCS	Kinase	GAPDH	CDK5	0.894381269	9.58E-44
UCS	TF	GAPDH	ETV2	0.801700179	1.37E-28
UCS	TF	GAPDH	ZNF444	0.81355319	4.95E-30
UCS	TF	GAPDH	PIN1	0.816331241	2.20E-30
UCS	TF	GAPDH	ZNF668	0.82055465	6.22E-31
UCS	TF	GAPDH	MYBL2	0.820831435	5.72E-31
UCS	TF	GAPDH	MAZ	0.826619083	9.58E-32
UCS	TF	GAPDH	MXD3	0.826894312	8.79E-32
UCS	TF	GAPDH	ZNF672	0.845804022	1.54E-34
UCS	TF	GAPDH	E2F1	0.847697353	7.80E-35
UCS	TF	GAPDH	PREB	0.848651933	5.51E-35
UCS	TF	GAPDH	MYPOP	0.852029997	1.58E-35
UCS	TF	GAPDH	USF1	0.863809251	1.57E-37
UCS	TF	GAPDH	GTF3A	0.881646381	6.00E-41
UCS	TSG	GAPDH	PIN1	0.816331241	2.20E-30
UCS	TSG	GAPDH	ZNF668	0.82055465	6.22E-31
UCS	TSG	GAPDH	ANP32A	0.823444842	2.57E-31
UCS	TSG	GAPDH	RAD51C	0.826766539	9.15E-32
UCS	TSG	GAPDH	BRMS1	0.838084843	2.27E-33
UCS	TSG	GAPDH	H2AFX	0.838115269	2.25E-33
UCS	TSG	GAPDH	E2F1	0.847697353	7.80E-35
UCS	TSG	GAPDH	NME1	0.847831041	7.43E-35
UCS	TSG	GAPDH	MYO1A	0.857379921	2.05E-36
UCS	TSG	GAPDH	FANCG	0.86559351	7.54E-38
UVM	Cell metabolism gene	GAPDH	TPI1	0.826545426	3.69E-21
UVM	Cell metabolism gene	GAPDH	ALDOA	0.870405216	1.02E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	GAPDH	ENO1	-1.02325508064814	0.000557802151888609
LIHC	GAPDH	PGK1	-1.62651308012298	0.000568486322514105
STAD	GAPDH	EPRS	-1.48171581324647	0.000789262883452143
KIRP	GAPDH	SIAH1	-1.37596029910525	0.00114433001726866
THCA	GAPDH	RPL13A	1.00055529557489	0.00121938003080576
LIHC	GAPDH	SIAH1	1.47099038865582	0.00197548163802745
STAD	GAPDH	SYNCRIP	-3.24695040489934	0.00222697434946895
CHOL	GAPDH	ALDOA	-2.83387560694992	0.00390625
CHOL	GAPDH	PLG	-2.31501506240181	0.00390625
KIRC	GAPDH	SIAH1	-1.33474518982333	0.00417312852243992
LIHC	GAPDH	ENO1	-1.32167947065926	0.0105240117726964
CHOL	GAPDH	HTT	-1.06148752250872	0.01171875
ESCA	GAPDH	ENO1	-1.15865001896573	0.013671875
ESCA	GAPDH	HTT	-1.11267300323171	0.013671875
BRCA	GAPDH	HTT	-1.12770251374077	0.020837402758111
READ	GAPDH	ENO1	-2.94309512655985	0.03125
ESCA	GAPDH	PGK1	-1.04591062145054	0.0322265625
KIRC	GAPDH	RPL13A	-2.22570045477256	1.02382991067149e-08
BRCA	GAPDH	TPI1	-1.37170663261113	1.36788884617068e-23
HNSC	GAPDH	PGK1	2.21538633644678	1.62206470122328e-06
KIRC	GAPDH	PLG	-1.2340406832486	1.84732884766841e-08
LIHC	GAPDH	EPRS	-7.10731017811505	2.28054594243154e-08
THCA	GAPDH	SYNCRIP	-3.15946429809988	2.46790521879123e-10
THCA	GAPDH	PGK1	1.06230877349493	2.71193687064843e-08
KIRC	GAPDH	PGK1	2.38099062998124	5.90713644357014e-13
KIRC	GAPDH	ENO1	1.29733189096776	6.21583666708237e-08
LIHC	GAPDH	HTT	-6.76350618083823	7.84143794524039e-06
BRCA	GAPDH	PGK1	-3.58045831848903	9.12761079680225e-22
HNSC	GAPDH	TPI1	2.18355531277556	9.12882633201663e-05
KIRP	GAPDH	PLG	-4.44004779974123	9.31322574615479e-10
PRAD	GAPDH	EPRS	-1.76339127457265	9.52775218277559e-05
HNSC	GAPDH	ENO1	1.01360337851514	9.68786002886192e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GAPDH

QRICH2, TXN, POU2F1, POU2F2, STIP1, NPAT, PLD2, LAMTOR5, PRDX1, ARL15, BTBD2, LAMA4, PAFAH1B3, PCDHA4, PSMD11, SERPINB9, TK1, RPA2, PRKCI, ATXN1, AR, PDIA2, PTK2, USP25, CDKN1A, SET, CCNB1, CBL, PPP2R2A, POU5F1, CD4, Mapk13, NR1H4, HNF4G, SIRT1, PCNA, MAPK1, PSMA3, GSK3B, BID, RBM5, KARS, HES1, ACTC1, GOT2, NFYC, OSMR, OSTF1, YWHAE, SNCA, KCNE3, ANXA1, SMN1, ANXA7, GADD45A, ARRB2, SLC2A4, EP300, TP53, TERF1, TINF2, ACD, POT1, HTT, GAPDH, PARK2, SIAH1, CUL3, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, KAT5, ISG15, MYOC, MDM2, ATN1, AKT1, GRB2, AP2M1, NPM1, APP, PSEN1, PGK1, TPI1, PKM, ENO1, HSPD1, EEF1A1, CSTF3, PGAM1, OLA1, PABPN1, HNRNPA3, ESR1, LIG4, HSP90AA1, HSP90AB1, BTK, FN1, VCAM1, ATF2, IQCB1, ITGA4, CD81, ICAM1, MAPK7, RAD52, ADRB2, EGFR, CDK17, YWHAQ, FBXO6, TRAP1, CDKN2A, PRPF40A, GAS7, CAPNS1, ACOT7, CRYZ, DCPS, DFFA, FERMT2, GBP1, HSPA9, METAP2, PPIB, RAP1GDS1, TUBA1A, TUBA1C, TUBB, TUFM, TYMP, UBQLN1, HSPA1L, MAT2B, PPP5C, YWHAG, rev, RPA3, RPA1, ASB15, ASB16, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, SIRT6, BLK, PRKY, MAP3K5, GAPDHS, ASPSCR1, HNRNPA1, AKR1A1, ASS1, CTBP1, DPYD, DTNB, DUT, ENO2, ENO3, ALDOA, CFL1, HSPA8, NLRP2, NUDC, PSMD3, SOD1, TACO1, TKT, GDPGP1, GLOD4, GPD1L, MSRB3, PGAM2, PRDX2, PRDX5, SMEK1, TANGO2, NTRK1, HSPB2, EWSR1, PPME1, CASC5, MED8, ANKRD36, Bmpr1a, Kif1c, MCM2, MCM5, CDC5L, ESRRB, CDC73, RABGGTA, ZIC1, GRIA2, SLC9A1, MTNR1A, CYLD, TRIM25, BRCA1, HDAC6, TARDBP, ZNF598, FBXO7, BCL2L1, PSMD4, HDAC4, KRAS, CTNNB1, JUP, PPP6C, YAF2, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, NKX2-1, AKTIP, CHD3, CHD4, RNF4, SPDL1, RIOK1, PRKCZ, ZUFSP, HEXIM1, MEPCE, RNF123, PPT1, SNAI1, AGR2, RECQL4, PIK3R1, ZFP36L2, MYC, CDK9, NEK2, GRWD1, KRT17, METTL3, METTL14, KIAA1429, PTPRF, FAF1, TET2, USP14, NR2C2, UBQLN2, OTUB2, BMH2, BMH1, ATXN3, MDH2, CUL4A, ITFG1, BIRC3, CTBP2, PPIA, TEX101, AGO2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, HCVgp1, LINC01554, ZC3H18, ERBB2, EMC1, EMC2, EMC4, MMGT1, ZNF891, ZNF646, NDUFB6, PHF19, HIST1H2AB, ZNF92, CROCC, KRT39, GPRC5A, SEC62, LNP1, SPAG6, SVIL, CDK5, G3BP1, OBSCN, TSHZ3, CDCA2, NEBL, NUP107, SLC4A3, CCDC38, SNIP1, ANKRD55, M, nsp13, nsp4, nsp6, SMC3, NIPBL, MAU2, ITGB5, DUX4, CIT, ANLN, CHMP4C, RXFP4, KIF14, KIF23, PRC1, NMRAL1, NDN, BRD4, Apc2, RBM39, LGALS9, KEAP1, TXNIP, INSIG2, RIN3, OGT, SPOP, UFL1, DDRGK1, DDX39B, TRIM37, ATG7, ATG3, FZR1, NUFIP2, SHANK3, SMARCA2, TSC2, WDR5, NUDCD2, NAA40, BGLT3, SYT6, SERBP1, RWDD2B, DNAJB6, CCAR2, SPRTN, USP11, BTF3, DPP4, E, ORF8, S, ORF10, FGD5, NBR1, MAGEL2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GAPDH	chr12	6640244	T	C	single_nucleotide_variant	Pathogenic	Microcephaly_21,_primary,_autosomal_recessive	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
GAPDH	chr12	6643991	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GAPDH	KIRC	chr12	6646512	6646512	G	T	Missense_Mutation	p.A161S	5
GAPDH	UCEC	chr12	6646115	6646115	A	G	Missense_Mutation	p.D89G	3
GAPDH	ESCA	chr12	6645892	6645892	G	A	Missense_Mutation	p.G58S	3
GAPDH	UCS	chr12	6646101	6646101	A	C	Missense_Mutation	p.K84N	3
GAPDH	HNSC	chr12	6646508	6646508	C	T	Silent	p.P159P	2
GAPDH	TGCT	chr12	6647109	6647109	T	C	Silent		2
GAPDH	CESC	chr12	6646823	6646823	G	T	Missense_Mutation		2
GAPDH	SKCM	chr12	6644008	6644008	G	A	Missense_Mutation	p.V4M	2
GAPDH	CESC	chr12	6646823	6646823	G	T	Missense_Mutation	p.R200L	2
GAPDH	KIRP	chr12	6646478	6646485	TGCCTCCT	-	Frame_Shift_Del	p.149_151del	2
GAPDH	SKCM	chr12	6645674	6645674	G	A	Missense_Mutation	p.G15E	2
GAPDH	UCEC	chr12	6646132	6646132	G	A	Missense_Mutation	p.V95I	2
GAPDH	UCEC	chr12	6647106	6647106	C	A	Silent	p.T294	2
GAPDH	STAD	chr12	6646855	6646855	A	G	Missense_Mutation		2
GAPDH	UCEC	chr12	6647361	6647361	A	G	Splice_Site	e6-2	2
GAPDH	KIRP	chr12	6645958	6645958	T	C	Splice_Site		2
GAPDH	SARC	chr12	6647317	6647317	A	C	Missense_Mutation		2
GAPDH	STAD	chr12	6646855	6646855	A	G	Missense_Mutation	p.T211A	2
GAPDH	ESCA	chr12	6646278	6646278	G	-	Frame_Shift_Del	p.Q113fs	2
GAPDH	SARC	chr12	6647317	6647317	A	C	Missense_Mutation	p.H330P	2
GAPDH	LUAD	chr12	6647123	6647123	G	A	Missense_Mutation	p.G300D	2
GAPDH	HNSC	chr12	6646845	6646845	C	A	Silent	p.I207I	2
GAPDH	STAD	chr12	6647006	6647006	T	C	Missense_Mutation	p.V261A	2
GAPDH	BRCA	chr12	6646882	6646882	G	C	Missense_Mutation	p.V220L	2
GAPDH	CESC	chr12	6643991	6643991	C	G	Missense_Mutation		2
GAPDH	BLCA	chr12	6645670	6645670	A	G	Missense_Mutation		1
GAPDH	LUSC	chr12	6645907	6645907	G	A	Missense_Mutation	p.E63K	1
GAPDH	HNSC	chr12	6646377	6646377	C	A	Silent		1
GAPDH	THCA	chr12	6646320	6646320	T	C	Silent		1
GAPDH	BLCA	chr12	6645883	6645883	A	G	Missense_Mutation		1
GAPDH	LUSC	chr12	6646779	6646779	G	T	Missense_Mutation	p.Q185H	1
GAPDH	HNSC	chr12	6647075	6647075	C	G	Missense_Mutation		1
GAPDH	SKCM	chr12	6646281	6646281	G	A	Silent	p.G72G	1
GAPDH	BLCA	chr12	6646380	6646380	C	G	Missense_Mutation		1
GAPDH	COAD	chr12	6645733	6645733	G	T	Missense_Mutation	p.D35Y	1
GAPDH	OV	chr12	6516803	6516803	G	C	Missense_Mutation	p.V171L	1
GAPDH	HNSC	chr12	6646845	6646845	C	A	Silent		1
GAPDH	BLCA	chr12	6647115	6647115	T	C	Silent		1
GAPDH	KIRP	chr12	6646478	6646485	TGCCTCCT	-	Frame_Shift_Del	p.NASC149fs	1
GAPDH	COAD	chr12	6646278	6646278	G	-	Frame_Shift_Del	p.Q71fs	1
GAPDH	PRAD	chr12	6645760	6645760	G	A	Splice_Site		1
GAPDH	HNSC	chr12	6646508	6646508	C	T	Silent		1
GAPDH	SKCM	chr12	6647267	6647267	G	A	Splice_Site	p.W313_splice	1
GAPDH	BLCA	chr12	6647116	6647116	G	T	Missense_Mutation		1
GAPDH	KIRP	chr12	6646478	6646485	TGCCTCCT	-	Frame_Shift_Del	p.N149fs	1
GAPDH	ESCA	chr12	6646278	6646278	G	-	Frame_Shift_Del	p.G115fs	1
GAPDH	SARC	chr12	6646086	6646086	G	T	Missense_Mutation		1
GAPDH	HNSC	chr12	6646891	6646891	G	A	Missense_Mutation		1
GAPDH	SKCM	chr12	6646283	6646283	G	A	Missense_Mutation	p.G115E	1
GAPDH	BLCA	chr12	6645883	6645883	A	G	Missense_Mutation	p.K55E	1
GAPDH	HNSC	chr12	6646520	6646520	C	T	Silent	p.V163V	1
GAPDH	SKCM	chr12	6645673	6645673	G	A	Missense_Mutation	p.G15R	1
GAPDH	UCS	chr12	6646101	6646101	A	C	Missense_Mutation		1
GAPDH	BLCA	chr12	6646380	6646380	C	G	Missense_Mutation	p.I147M	1
GAPDH	LIHC	chr12	6646092	6646093	-	C	Frame_Shift_Ins	p.L82fs	1
GAPDH	ESCA	chr12	6646278	6646278	G	-	Frame_Shift_Del		1
GAPDH	SARC	chr12	6643975	6643975	G	T	Splice_Site		1
GAPDH	HNSC	chr12	6647075	6647075	C	G	Missense_Mutation	p.S284C	1
GAPDH	SKCM	chr12	6646281	6646281	G	A	Silent	p.G114G	1
GAPDH	STAD	chr12	6646936	6646936	G	T	Missense_Mutation	p.A238S	1
GAPDH	BLCA	chr12	6647116	6647116	G	T	Missense_Mutation	p.G298W	1
GAPDH	LIHC	chr12	6646825	6646825	G	-	Frame_Shift_Del	p.G201fs	1
GAPDH	HNSC	chr12	6646377	6646377	C	A	Silent	p.I146I	1
GAPDH	SKCM	chr12	6644007	6644007	G	A	Translation_Start_Site		1
GAPDH	STAD	chr12	6647143	6647156	TTTGTCAAGCTCAT	-	Frame_Shift_Del	p.306_311del	1
GAPDH	BLCA	chr12	6647115	6647115	T	C	Silent	p.A297A	1
GAPDH	ESCA	chr12	6644003	6644003	G	T	Missense_Mutation	p.G2V	1
GAPDH	SKCM	chr12	6646283	6646283	G	A	Missense_Mutation	p.G73E	1
GAPDH	LUAD	chr12	6647021	6647021	C	T	Missense_Mutation	p.S266L	1
GAPDH	GBM	chr12	6647098	6647098	T	G	Missense_Mutation	p.S292A	1
GAPDH	SKCM	chr12	6647267	6647267	G	A	Nonsense_Mutation	p.W271X	1
GAPDH	HNSC	chr12	6646891	6646891	G	A	Missense_Mutation	p.E223K	1
GAPDH	STAD	chr12	6647143	6647156	TTTGTCAAGCTCAT	-	Frame_Shift_Del	p.F307fs	1
GAPDH	LUAD	chr12	6646140	6646140	G	T	Missense_Mutation	p.E97D	1
GAPDH	GBM	chr12	6647098	6647098	T	G	Missense_Mutation		1
GAPDH	SKCM	chr12	6644007	6644007	G	A	Silent	p.K3K	1

Copy number variation (CNV) of GAPDH
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GAPDH
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103040	N/A	U34995	ALKBH5	chr17	18087143	-	GAPDH	chr12	6643694	+
103040	GBM	TCGA-41-4097-01A	ATP2A2	chr12	110771088	+	GAPDH	chr12	6647364	+
103040	N/A	AW277218	ATXN1	chr6	16559598	-	GAPDH	chr12	6647537	-
103040	N/A	BQ420306	CALML4	chr15	68490023	+	GAPDH	chr12	6647483	+
103040	N/A	BI117444	CDKN1A	chr6	36654550	+	GAPDH	chr12	6643705	+
103040	LUSC	TCGA-63-5128	COL4A2	chr13	111138107	+	GAPDH	chr12	6645663	+
103040	BLCA	TCGA-GV-A3QI-01A	DHRS2	chr14	24105981	+	GAPDH	chr12	6645660	+
103040	SARC	TCGA-DX-A1KZ-01A	FKBP4	chr12	2907037	+	GAPDH	chr12	6643976	+
101149	LUSC	TCGA-66-2783-01A	GAPDH	chr12	6643735	+	ACTB	chr7	5569294	-
101271	Non-Cancer	ERR188388	GAPDH	chr12	6646544	+	ACTG1	chr17	79479145	-
95898	N/A	BF344908	GAPDH	chr12	6647529	+	ADAMTSL1	chr9	18428426	+
91473	N/A	BF337259	GAPDH	chr12	6647537	+	ALPK2	chr18	56261175	+
94146	LIHC	TCGA-CC-A7IL-01A	GAPDH	chr12	6647481	-	APOA2	chr1	161193418	-
98737	N/A	BF337442	GAPDH	chr12	6647532	+	ATP8A2	chr13	25967045	+
87261	.	.	GAPDH	chr12	6644027	+	BCL6	chr3	187452695	-
32426	OV	TCGA-20-1687	GAPDH	chr12	6643735	+	CLDN3	chr7	73184600	-
99610	LUSC	TCGA-22-4593-01A	GAPDH	chr12	6647162	+	COL3A1	chr2	189862426	+
98985	N/A	BF526913	GAPDH	chr12	6647537	+	DOCK11	chrX	117738516	-
59691	N/A	AX396450	GAPDH	chr12	6646516	+	ECHS1	chr10	135179503	-
100195	N/A	BF525449	GAPDH	chr12	6647534	+	EFCAB6	chr22	43944420	+
100195	N/A	BM014593	GAPDH	chr12	6647534	+	EFCAB6	chr22	43944421	+
93134	N/A	BQ314751	GAPDH	chr12	6646143	+	EIF1	chr17	39847268	+
77753	READ	TCGA-AG-3887	GAPDH	chr12	6645955	+	FAM159B	chr5	63986326	+
32426	N/A	BF343739	GAPDH	chr12	6647541	+	FAM230A	chr22	20340438	-
103040	N/A	AA229834	GAPDH	chr12	6647435	+	GAPDH	chr12	6647418	-
103040	N/A	AW118507	GAPDH	chr12	6647453	-	GAPDH	chr12	6647317	+
103040	N/A	BF337613	GAPDH	chr12	6647371	-	GAPDH	chr12	6647442	+
103040	N/A	BI003826	GAPDH	chr12	6643683	-	GAPDH	chr12	6643978	+
103040	N/A	EC562809	GAPDH	chr12	6647514	+	GAPDH	chr12	6647353	+
102237	LIHC	TCGA-CC-5263-01A	GAPDH	chr12	6647351	+	H2AFV	chr7	44866840	-
92763	SKCM	TCGA-EE-A3AG-06A	GAPDH	chr12	6647481	-	HSPB1	chr7	75931861	+
32426	N/A	EC500536	GAPDH	chr12	6647534	+	IFFO1	chr12	6647686	+
99272	CESC	TCGA-FU-A5XV-01A	GAPDH	chr12	6647000	-	JUP	chr17	39911487	-
99572	HNSC	TCGA-HD-7229	GAPDH	chr12	6645919	+	KRT17	chr17	39778724	-
95288	HNSC	TCGA-CN-4742	GAPDH	chr12	6647463	+	KRT6A	chr12	52886936	-
100826	N/A	BF526283	GAPDH	chr12	6647534	+	LAMA3	chr18	21275758	+
98938	N/A	BF337211	GAPDH	chr12	6647535	+	LRP1B	chr2	141275300	-
64479	N/A	BF344678	GAPDH	chr12	6647537	+	MAGT1	chrX	77105389	+
97528	STAD	TCGA-D7-5577-01A	GAPDH	chr12	6647524	+	MAN1C1	chr1	26112407	+
100243	OV	TCGA-04-1361	GAPDH	chr12	6643735	+	MRPL51	chr12	6602138	-
32426	N/A	BF816390	GAPDH	chr12	6643686	-	MRPS17	chr7	56022696	+
60020	LUAD	TCGA-44-4112-01A	GAPDH	chr12	6644027	+	NCAPD2	chr12	6637339	+
87000	N/A	BP277720	GAPDH	chr12	6646494	+	NUFIP2	chr17	27620990	-
98891	COAD	TCGA-AA-3514-01A	GAPDH	chr12	6646176	+	PDE6A	chr5	149246803	-
101118	N/A	BC013852	GAPDH	chr12	6647444	+	PEA15	chr1	160184354	+
102075	N/A	BF527013	GAPDH	chr12	6647536	+	RBMS3	chr3	29466697	+
80746	N/A	DW440511	GAPDH	chr12	6646535	+	RPL23	chr17	37009979	-
98635	LUAD	TCGA-97-8175-01A	GAPDH	chr12	6647470	-	SERPINA1	chr14	94844936	-
98635	N/A	CB147232	GAPDH	chr12	6646881	-	SERPINA1	chr14	94854945	-
97282	N/A	BM148786	GAPDH	chr12	6646382	+	SLC39A11	chr17	70900950	-
102901	OV	TCGA-25-1316	GAPDH	chr12	6643735	+	SNRPD2	chr19	46191824	-
96115	N/A	DA446259	GAPDH	chr12	6645897	+	SON	chr21	34927473	+
91923	N/A	BF342117	GAPDH	chr12	6647534	+	TMEM97	chr17	26650477	-
66827	N/A	AA593512	GAPDH	chr12	6647534	+	TMIGD1	chr17	28646450	+
99184	HNSC	TCGA-CN-6024-01A	GAPDH	chr12	6646176	+	TNC	chr9	117783546	-
92759	N/A	BF337526	GAPDH	chr12	6647537	+	TRIOBP	chr22	38128516	+
102850	OV	TCGA-24-2038	GAPDH	chr12	6643735	+	UBC	chr12	125398320	-
100935	N/A	BF343557	GAPDH	chr12	6647537	+	UBQLN1	chr9	86288462	+
102307	N/A	BF526075	GAPDH	chr12	6647537	+	ZNF532	chr18	56572093	-
103040	CESC	TCGA-IR-A3LI-01A	GNAS	chr20	57478846	+	GAPDH	chr12	6647267	+
103040	N/A	BG232146	HIC2	chr22	21786965	-	GAPDH	chr12	6647537	-
103040	N/A	BM144198	HS3ST4	chr16	26073951	+	GAPDH	chr12	6647535	-
103040	Non-Cancer	ERR188353	IGHA1	chr14	106174693	-	GAPDH	chr12	6647419	+
103040	N/A	BM144199	ITGB8	chr7	20378811	-	GAPDH	chr12	6647532	-
103040	N/A	BM464550	KATNBL1	chr15	34439844	+	GAPDH	chr12	6645907	+
103040	N/A	EC583093	KLHL8	chr4	88102786	+	GAPDH	chr12	6647047	-
103040	Non-Cancer	ERR315469	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
103040	N/A	BG926120	PDCD4	chr10	112641287	+	GAPDH	chr12	6646488	+
103040	N/A	BE255519	PRMT2	chr21	48081784	+	GAPDH	chr12	6645706	+
103040	N/A	AW498880	RPL28	chr19	55899730	+	GAPDH	chr12	6644002	+
103040	OV	TCGA-13-0901-01B	RPS14	chr5	149826365	-	GAPDH	chr12	6647331	+
103040	N/A	BP430119	RPS16	chr19	39924313	-	GAPDH	chr12	6647295	+
103040	N/A	CV312017	SKP1	chr5	133497575	+	GAPDH	chr12	6646910	+
103040	N/A	BF820683	SRRT	chr7	100484540	+	GAPDH	chr12	6647322	+
103040	N/A	AJ711772	TOMM6	chr6	41757469	+	GAPDH	chr12	6647011	+
103040	N/A	BC044944	ZNF638	chr2	71603450	+	GAPDH	chr12	6647482	+
103041	N/A	DB548780	ZNF836	chr19	52659282	-	GAPDH	chr12	6647484	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	GAPDH	0.00549532951152461	0.15
LUAD	GAPDH	0.00853817737896347	0.23
READ	GAPDH	0.0270810498045807	0.7
THCA	GAPDH	0.0488887792741497	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	GAPDH	0.0499381707212634	1
LGG	GAPDH	8.8221316441283e-05	0.0029
BRCA	GAPDH	0.0442977633907641	1
ESCA	GAPDH	0.000253404288559409	0.0081
THYM	GAPDH	0.0209158791590255	0.65
SARC	GAPDH	0.0408541716299452	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P04406	DB02059	Adenosine-5-Diphosphoribose		Small molecule	Experimental
P04406	DB03893	Thionicotinamide-Adenine-Dinucleotide		Small molecule	Experimental
P04406	DB07347	4-(2-Aminoethyl)Benzenesulfonyl Fluoride		Small molecule	Experimental
P04406	DB09092	Xanthinol	Cofactor	Small molecule	Approved\|Withdrawn
P04406	DB02059	Adenosine-5-Diphosphoribose
P04406	DB03893	Thionicotinamide-Adenine-Dinucleotide
P04406	DB07347	4-(2-Aminoethyl)Benzenesulfonyl Fluoride
P04406	DB09092	Xanthinol	Cofactor

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C2239176	Liver carcinoma	2	CTD_human
C0001787	Osteoporosis, Age-Related	1	CTD_human
C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
C0007137	Squamous cell carcinoma	1	CTD_human
C0009402	Colorectal Carcinoma	1	CTD_human
C0029408	Degenerative polyarthritis	1	CTD_human
C0029456	Osteoporosis	1	CTD_human
C0029459	Osteoporosis, Senile	1	CTD_human
C0086743	Osteoarthrosis Deformans	1	CTD_human
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
C0546837	Malignant neoplasm of esophagus	1	CTD_human
C0751406	Post-Traumatic Osteoporosis	1	CTD_human
C0948089	Acute Coronary Syndrome	1	CTD_human