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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL13 (NCBI Gene ID:28998)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL13
	Gene ID: 28998
	Gene Symbol	MRPL13
	Gene ID	28998
	Gene Name	mitochondrial ribosomal protein L13
	Synonyms	L13\|L13A\|L13mt\|RPL13\|RPML13
	Cytomap	8q24.12
	Type of Gene	protein-coding
	Description	39S ribosomal protein L13, mitochondrialMRP-L13mitochondrial large ribosomal subunit protein uL13m
	Modification date	20200313
	UniProtAcc	Q9BYD1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL13	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL13[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL13	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000306185	121426229	121426351	Frame-shift
ENST00000306185	121437545	121437606	Frame-shift
ENST00000306185	121444269	121444363	Frame-shift
ENST00000306185	121455424	121455548	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	MRPL13	1.54402472107614	0.000655351190157038
ESCA	MRPL13	-1.07746088474995	0.0068359375

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	MRPL13	0.427664241	0.01223592
MESO	MRPL13	0.123377679	0.020594699

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL13 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	MRPL13	POLR2K	0.802949775	1.80E-75
DLBC	Epifactor	MRPL13	ENY2	0.80126307	7.91E-12
GBM	Cell metabolism gene	MRPL13	DPM1	0.807169852	9.17E-41
GBM	Cell metabolism gene	MRPL13	MLX	0.807264161	8.84E-41
GBM	Cell metabolism gene	MRPL13	ADH5	0.808333415	5.78E-41
GBM	Cell metabolism gene	MRPL13	PSMB3	0.808401096	5.63E-41
GBM	Cell metabolism gene	MRPL13	PFDN5	0.811556167	1.59E-41
GBM	Cell metabolism gene	MRPL13	TIMM8B	0.812522915	1.07E-41
GBM	Cell metabolism gene	MRPL13	LSM3	0.813040554	8.67E-42
GBM	Cell metabolism gene	MRPL13	LYPLA1	0.815257775	3.48E-42
GBM	Cell metabolism gene	MRPL13	PSMA7	0.817099415	1.61E-42
GBM	Cell metabolism gene	MRPL13	NME2	0.822684007	1.49E-43
GBM	Cell metabolism gene	MRPL13	PSMB4	0.836983783	2.24E-46
GBM	Cell metabolism gene	MRPL13	PSMD14	0.842473524	1.56E-47
GBM	Cell metabolism gene	MRPL13	SDHC	0.851581684	1.49E-49
GBM	Cell metabolism gene	MRPL13	GEMIN6	0.867115214	2.47E-53
GBM	Cell metabolism gene	MRPL13	SNRPG	0.870827452	2.62E-54
GBM	Cell metabolism gene	MRPL13	POLR2K	0.872902382	7.24E-55
GBM	Cell metabolism gene	MRPL13	PSMA5	0.879235397	1.24E-56
GBM	Cell metabolism gene	MRPL13	LSM1	0.916387137	1.69E-69
GBM	CGC	MRPL13	SDHC	0.851581684	1.49E-49
GBM	Epifactor	MRPL13	ENY2	0.851584579	1.49E-49
GBM	Epifactor	MRPL13	DPY30	0.85784459	5.04E-51
GBM	IUPHAR	MRPL13	ITGAE	0.80648635	1.20E-40
GBM	IUPHAR	MRPL13	PSMD14	0.842473524	1.56E-47
GBM	TF	MRPL13	GTF2B	0.805448625	1.80E-40
GBM	TF	MRPL13	MLX	0.807264161	8.84E-41
GBM	TF	MRPL13	NME2	0.822684007	1.49E-43
HNSC	Epifactor	MRPL13	ENY2	0.829605412	7.28E-145
LIHC	Cell metabolism gene	MRPL13	POLR2K	0.827649208	1.16E-107
LIHC	Epifactor	MRPL13	ENY2	0.859581845	7.93E-125
PRAD	Epifactor	MRPL13	ENY2	0.812261074	2.13E-130
SKCM	Cell metabolism gene	MRPL13	POLR2K	0.8225388	9.06E-118
TGCT	Cell metabolism gene	MRPL13	PSMB2	0.802438051	2.35E-36
TGCT	Cell metabolism gene	MRPL13	PSMA5	0.817144174	1.12E-38
TGCT	IUPHAR	MRPL13	PSMB2	0.802438051	2.35E-36
TGCT	TSG	MRPL13	PHB	0.809552868	1.88E-37
THYM	Cell metabolism gene	MRPL13	SDHB	0.813508558	5.01E-30
THYM	Cell metabolism gene	MRPL13	PSMA2	0.827442541	7.39E-32
THYM	Cell metabolism gene	MRPL13	RAE1	0.83854621	1.94E-33
THYM	CGC	MRPL13	SDHB	0.813508558	5.01E-30
THYM	Epifactor	MRPL13	ENY2	0.85723466	2.17E-36
THYM	TSG	MRPL13	SDHB	0.813508558	5.01E-30
UCS	Cell metabolism gene	MRPL13	SDHB	0.813508558	5.01E-30
UCS	Cell metabolism gene	MRPL13	PSMA2	0.827442541	7.39E-32
UCS	Cell metabolism gene	MRPL13	RAE1	0.83854621	1.94E-33
UCS	CGC	MRPL13	SDHB	0.813508558	5.01E-30
UCS	Epifactor	MRPL13	ENY2	0.85723466	2.17E-36
UCS	TSG	MRPL13	SDHB	0.813508558	5.01E-30
UVM	Cell metabolism gene	MRPL13	GFPT1	0.80019212	5.37E-19
UVM	Cell metabolism gene	MRPL13	TBCE	0.801046475	4.62E-19
UVM	Cell metabolism gene	MRPL13	MCEE	0.80641987	1.77E-19
UVM	Cell metabolism gene	MRPL13	SAR1B	0.810669014	8.13E-20
UVM	Cell metabolism gene	MRPL13	MED30	0.815040708	3.57E-20
UVM	Cell metabolism gene	MRPL13	RAP1B	0.817971475	2.03E-20
UVM	Cell metabolism gene	MRPL13	ALG5	0.823671433	6.60E-21
UVM	Cell metabolism gene	MRPL13	MDH1	0.824016288	6.16E-21
UVM	Cell metabolism gene	MRPL13	PDP1	0.826554775	3.68E-21
UVM	Cell metabolism gene	MRPL13	PIK3C2A	0.833353268	8.87E-22
UVM	Cell metabolism gene	MRPL13	PSMC2	0.837248321	3.81E-22
UVM	Cell metabolism gene	MRPL13	TIMM17A	0.839014447	2.58E-22
UVM	Cell metabolism gene	MRPL13	PSME4	0.841242568	1.57E-22
UVM	Cell metabolism gene	MRPL13	PSMA4	0.853437437	8.86E-24
UVM	Cell metabolism gene	MRPL13	PSMD12	0.856611403	4.02E-24
UVM	Cell metabolism gene	MRPL13	LYPLA1	0.858834488	2.28E-24
UVM	Cell metabolism gene	MRPL13	PSMA3	0.861997682	1.00E-24
UVM	Cell metabolism gene	MRPL13	PSMA6	0.867944508	2.03E-25
UVM	Cell metabolism gene	MRPL13	TGS1	0.871841218	6.81E-26
UVM	Cell metabolism gene	MRPL13	IMPA1	0.880890562	4.68E-27
UVM	Cell metabolism gene	MRPL13	PSMD14	0.881819384	3.51E-27
UVM	Cell metabolism gene	MRPL13	TRAM1	0.903149665	2.26E-30
UVM	Cell metabolism gene	MRPL13	YWHAZ	0.90862505	2.60E-31
UVM	Cell metabolism gene	MRPL13	SLC25A32	0.919237816	2.59E-33
UVM	Cell metabolism gene	MRPL13	POLR2K	0.923768591	2.97E-34
UVM	Cell metabolism gene	MRPL13	AZIN1	0.934666118	8.94E-37
UVM	CGC	MRPL13	UBR5	0.885029442	1.28E-27
UVM	CGC	MRPL13	TCEA1	0.886637876	7.61E-28
UVM	CGC	MRPL13	RAD21	0.910949991	9.96E-32
UVM	CGC	MRPL13	NBN	0.915773972	1.25E-32
UVM	Epifactor	MRPL13	SMARCA5	0.802732855	3.43E-19
UVM	Epifactor	MRPL13	TAF5	0.807554924	1.44E-19
UVM	Epifactor	MRPL13	MASTL	0.814902429	3.67E-20
UVM	Epifactor	MRPL13	ACTR6	0.817216617	2.35E-20
UVM	Epifactor	MRPL13	PDP1	0.826554775	3.68E-21
UVM	Epifactor	MRPL13	ANP32E	0.828236434	2.60E-21
UVM	Epifactor	MRPL13	CBX3	0.848492735	2.93E-23
UVM	Epifactor	MRPL13	ATAD2	0.853130431	9.55E-24
UVM	Epifactor	MRPL13	RAD54B	0.874235143	3.42E-26
UVM	Epifactor	MRPL13	UBR5	0.885029442	1.28E-27
UVM	Epifactor	MRPL13	TAF2	0.889663213	2.81E-28
UVM	Epifactor	MRPL13	PHF20L1	0.899795573	8.00E-30
UVM	Epifactor	MRPL13	ENY2	0.903675385	1.85E-30
UVM	Epifactor	MRPL13	YWHAZ	0.90862505	2.60E-31
UVM	Epifactor	MRPL13	NBN	0.915773972	1.25E-32
UVM	IUPHAR	MRPL13	MAP4K3	0.800064293	5.49E-19
UVM	IUPHAR	MRPL13	NIPAL2	0.802116057	3.83E-19
UVM	IUPHAR	MRPL13	TBK1	0.802754057	3.42E-19
UVM	IUPHAR	MRPL13	IDE	0.804084293	2.70E-19
UVM	IUPHAR	MRPL13	VRK2	0.806445827	1.76E-19
UVM	IUPHAR	MRPL13	NSMAF	0.806583925	1.72E-19
UVM	IUPHAR	MRPL13	MASTL	0.814902429	3.67E-20
UVM	IUPHAR	MRPL13	TMEM165	0.817916571	2.06E-20
UVM	IUPHAR	MRPL13	ABCB10	0.821444907	1.03E-20
UVM	IUPHAR	MRPL13	PIK3C2A	0.833353268	8.87E-22
UVM	IUPHAR	MRPL13	ATAD2	0.853130431	9.55E-24
UVM	IUPHAR	MRPL13	ATP6V1H	0.862230722	9.45E-25
UVM	IUPHAR	MRPL13	PTK2	0.874833946	2.87E-26
UVM	IUPHAR	MRPL13	IMPA1	0.880890562	4.68E-27
UVM	IUPHAR	MRPL13	PSMD14	0.881819384	3.51E-27
UVM	IUPHAR	MRPL13	ATP6V1C1	0.888972487	3.54E-28
UVM	IUPHAR	MRPL13	STK3	0.901863049	3.69E-30
UVM	IUPHAR	MRPL13	CYP51A1	0.908513271	2.72E-31
UVM	IUPHAR	MRPL13	SLC25A32	0.919237816	2.59E-33
UVM	Kinase	MRPL13	MAP4K3	0.800064293	5.49E-19
UVM	Kinase	MRPL13	TBK1	0.802754057	3.42E-19
UVM	Kinase	MRPL13	VRK2	0.806445827	1.76E-19
UVM	Kinase	MRPL13	MASTL	0.814902429	3.67E-20
UVM	Kinase	MRPL13	PTK2	0.874833946	2.87E-26
UVM	Kinase	MRPL13	STK3	0.901863049	3.69E-30
UVM	TF	MRPL13	ZNF251	0.800151233	5.40E-19
UVM	TF	MRPL13	ZNF250	0.808665963	1.18E-19
UVM	TF	MRPL13	ZNF572	0.829106217	2.17E-21
UVM	TF	MRPL13	E2F5	0.838110853	3.15E-22
UVM	TF	MRPL13	TERF1	0.873812676	3.87E-26
UVM	TF	MRPL13	ZNF7	0.893719396	7.06E-29
UVM	TSG	MRPL13	DNAJA3	0.82132279	1.05E-20
UVM	TSG	MRPL13	NBN	0.915773972	1.25E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPL13	MRPL32	-3.7979134181794	0.000134327661287861
STAD	MRPL13	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL13	MRPL11	-1.04966837625557	0.000354478033746394
KIRC	MRPL13	MRPL24	-1.34802117098363	0.000369980864421695
KIRC	MRPL13	MRPL46	-7.36081421944909	0.0011460554764592
LUAD	MRPL13	MRPL32	-2.1966239418264	0.00121089428940613
KIRP	MRPL13	MRPL46	-7.17671685013906	0.00123529229313135
BLCA	MRPL13	MRPL27	-4.19270554058168	0.00202178955078125
KICH	MRPL13	MRPL24	1.42000841970622	0.00378090143203735
CHOL	MRPL13	MRPL3	-2.68429255990621	0.00390625
CHOL	MRPL13	MRPL46	-2.73791743817321	0.00390625
ESCA	MRPL13	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL13	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL13	MRPL17	-1.18756178214998	0.009765625
LIHC	MRPL13	MRPL17	-1.06225729770915	0.0124123499319886
KIRP	MRPL13	MRPL24	-2.9092481117556	0.0139979305677116
STAD	MRPL13	MRPL4	1.4393539135682	0.0279771662317216
KIRC	MRPL13	MRPL32	-2.79664327578899	0.0376051795400881
LUAD	MRPL13	MRPL24	-3.53731160751159	1.10656371043093e-09
PRAD	MRPL13	MRPL11	1.12581653394628	1.15996224044503e-05
BRCA	MRPL13	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL13	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL13	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL13	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL13	MRPL3	1.69955762234244	1.97132191719422e-08
LIHC	MRPL13	MRPL32	-1.20074144698753	2.24402029682138e-06
LIHC	MRPL13	MRPL24	1.01230339617377	2.71217975233539e-06
COAD	MRPL13	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL13	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL13	MRPL27	-1.81809468729316	3.90393047420304e-06
BRCA	MRPL13	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL13	MRPL17	-6.83409683292749	6.93230040561614e-07
LUSC	MRPL13	MRPL24	-2.80841690659614	7.95689711347621e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL13

OXA1L, ICT1, MRPL11, MRPS9, MRPL17, MRPL16, MRPL3, MRPL14, MRPL15, MRPL42, MRPL23, MRPL55, MRPL45, MRPL39, MRPS28, MRPL10, MRPL52, MRPL24, MRPL38, MRPL41, MRPL9, MRPL2, MRPL19, MRPL44, SCFD1, OGDH, MPV17, DLD, SLC25A3, HNRNPU, NDUFB10, NDUFS1, CUL7, FN1, MOV10, FBXW11, RPL13, MRPL28, RPL6, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL37, MRPS30, MRPL47, MRPL18, MRPL50, MRPL1, TIGD6, Fbxw11, Brwd3, DHRS4, C6orf203, NDUFS3, LYRM2, PPM1K, COQ6, COQ4, COQ2, CDC14B, DUSP11, MRPL12, MRPL35, RPL18, PPAN, RPL7, ZNF324B, PDGFB, CYLD, PDHA1, GINS4, MTBP, MTOR, PPP2R1A, WDR61, ESR2, MEPCE, LARP7, DPF2, RECQL4, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, LTN1, SNRNP70, NFX1, Hsp22, PLEKHA4, ERCC6, KIF14, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, CHCHD1, CS, FASTKD2, FASTKD5, GFM1, GFM2, GRSF1, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, SSBP1, TACO1, TBRG4, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, DNAJA3, DNAJC15, DNAJC19, DNAJC28, DNAJC9, HSCB, MRPL27, MRPL49, MRPL22, MRPL21, MKRN1, PARK2, SRSF3, RNMTL1, MRPL48, NUPL2, RPL32, FAM120A, MRPS18A, PRR3, GLO1, RPL37, RPL13A, MRPL34, RBMS2, MRPL51, RPL26, PTCD1, IGF2BP3, SRSF5, RPL17, MRPL30, YBX2, HIST1H2AM, RPL19, MRPL40, LIN28A, MALSU1, MRPL32, RPL36AL, RPL23AP32, MRPL53, MRPL43, MRPL20, GADD45GIP1, H1FNT, H2AFB3, GNL3, YBX1, MRPL57, MRPL46, MRPL33, RPS9, RPL27A, DDX28, ZNF346, RPL23A, HNRNPCL1, ZNF574, FAHD1, MRPL54, RPL31, RPUSD3, RPL10, RBMS3, SRSF7, WBSCR16, NEIL1, RPL35, APOBEC3D, RPL4, RPL3, GTPBP10, YARS2, BTF3, WIPI1, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPL13	chr8	121455555	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL13	KIRP	chr8	121455496	121455496	G	A	Missense_Mutation	p.P27L	10
MRPL13	KIRP	chr8	121455496	121455496	G	A	Missense_Mutation		4
MRPL13	PAAD	chr8	121426282	121426282	G	A	Silent	p.L155L	3
MRPL13	BRCA	chr8	121432115	121432115	T	C	Missense_Mutation	p.R124G	3
MRPL13	LUAD	chr8	121457313	121457313	G	A	Missense_Mutation	p.P8S	3
MRPL13	PAAD	chr8	121426282	121426282	G	A	Silent		2
MRPL13	LIHC	chr8	121444294	121444294	T	C	Missense_Mutation	p.Q74R	2
MRPL13	BLCA	chr8	121426333	121426333	G	C	Missense_Mutation	p.L138V	2
MRPL13	STAD	chr8	121426273	121426273	A	G	Missense_Mutation	p.Y158H	2
MRPL13	PCPG	chr8	121432125	121432125	T	G	Silent	p.T120T	2
MRPL13	LIHC	chr8	121455507	121455507	C	-	Frame_Shift_Del	p.G23fs	2
MRPL13	PRAD	chr8	121426335	121426335	A	C	Missense_Mutation	p.I137S	2
MRPL13	ESCA	chr8	121426269	121426269	G	T	Missense_Mutation	p.T159K	2
MRPL13	SKCM	chr8	121426320	121426320	A	G	Missense_Mutation	p.V142A	2
MRPL13	SKCM	chr8	121457312	121457312	G	A	Missense_Mutation	p.P8L	2
MRPL13	ESCA	chr8	121455468	121455468	A	G	Silent	p.S36S	2
MRPL13	BLCA	chr8	121426299	121426299	C	T	Missense_Mutation	p.R149Q	1
MRPL13	GBM	chr8	121432169	121432170	-	T	Frame_Shift_Ins	p.K105fs	1
MRPL13	STAD	chr8	121444341	121444343	AAC	-	In_Frame_Del	p.58_59del	1
MRPL13	HNSC	chr8	121437559	121437559	C	A	Missense_Mutation		1
MRPL13	LIHC	chr8	121455541	121455542	-	C	Frame_Shift_Ins	p.H12fs	1
MRPL13	PCPG	chr8	121432125	121432125	T	G	Silent		1
MRPL13	UCEC	chr8	121455499	121455499	T	C	Missense_Mutation	p.Q26R	1
MRPL13	LIHC	chr8	121455503	121455503	T	-	Frame_Shift_Del	p.M25fs	1
MRPL13	COAD	chr8	121432141	121432141	T	-	Frame_Shift_Del	p.N115fs	1
MRPL13	UCEC	chr8	121444270	121444270	C	A	Missense_Mutation	p.G82_splice	1
MRPL13	COAD	chr8	121432151	121432151	G	A	Silent	p.L112L	1
MRPL13	LGG	chr8	121426350	121426350	T	C	Splice_Site	p.Y132_splice	1
MRPL13	LIHC	chr8	121444290	121444290	T	-	Frame_Shift_Del	p.K75fs	1
MRPL13	COAD	chr8	121444282	121444282	G	A	Missense_Mutation	p.S78F	1
MRPL13	READ	chr8	121426300	121426300	G	A	Nonsense_Mutation	p.R149X	1
MRPL13	LIHC	chr8	121426258	121426258	T	C	Missense_Mutation		1
MRPL13	LIHC	chr8	121444352	121444352	C	-	Frame_Shift_Del	p.D55fs	1
MRPL13	READ	chr8	121444364	121444364	C	G	Splice_Site	.	1
MRPL13	ESCA	chr8	121455468	121455468	A	G	Silent	p.S36	1
MRPL13	LIHC	chr8	121444294	121444294	T	C	Missense_Mutation		1
MRPL13	LUAD	chr8	121437552	121437552	T	A	Silent	p.P100P	1
MRPL13	LIHC	chr8	121408364	121408364	T	C	Silent		1
MRPL13	LUAD	chr8	121444300	121444300	C	A	Missense_Mutation	p.W72L	1
MRPL13	ESCA	chr8	121455468	121455468	A	G	Silent		1
MRPL13	LIHC	chr8	121408362	121408362	G	T	Missense_Mutation		1
MRPL13	BLCA	chr8	121426299	121426299	C	T	Missense_Mutation		1
MRPL13	LUAD	chr8	121444298	121444298	C	G	Missense_Mutation	p.E73Q	1
MRPL13	ESCA	chr8	121426339	121426339	C	A	Missense_Mutation	p.D136Y	1
MRPL13	SKCM	chr8	121426231	121426231	G	A	Splice_Site	p.P172_splice	1
MRPL13	LIHC	chr8	121426290	121426290	G	T	Missense_Mutation		1
MRPL13	BLCA	chr8	121426333	121426333	G	C	Missense_Mutation		1
MRPL13	SKCM	chr8	121426230	121426230	G	A	Splice_Site	p.P172_splice	1
MRPL13	LIHC	chr8	121455467	121455467	T	C	Missense_Mutation	p.I37V	1

Copy number variation (CNV) of MRPL13
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL13
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
88777	BLCA	TCGA-G2-A2EO-01A	ASAP1	chr8	131226802	-	MRPL13	chr8	121393413	-
88777	BLCA	TCGA-E7-A7DV-01A	FAM49B	chr8	130915558	-	MRPL13	chr8	121444363	-
88777	BLCA	TCGA-E7-A7DV-01A	FAM49B	chr8	130915558	-	MRPL13	chr8	121455548	-
88777	N/A	AX341668	GRAMD1B	chr11	123272093	-	MRPL13	chr8	121444363	-
88777	N/A	FN124574	GRAMD1B	chr11	123272123	+	MRPL13	chr8	121455423	+
102967	N/A	AX351352	MRPL13	chr8	121444363	+	GRAMD1B	chr11	123272093	+
102668	BRCA	TCGA-A2-A3XT-01A	MRPL13	chr8	121426230	-	RNF130	chr5	179467647	-
102784	N/A	EC558027	MRPL13	chr8	121455670	-	SRSF1	chr17	56080876	+
88777	N/A	FN176556	NVL	chr1	224427032	-	MRPL13	chr8	121432092	+
88779	OV	TCGA-30-1718-01A	TAF2	chr8	120814034	-	MRPL13	chr8	121393413	-
88779	STAD	TCGA-FP-8209-01A	TAF2	chr8	120768246	-	MRPL13	chr8	121408364	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
ESCA	MRPL13	0.00589016377284225	0.16
LUAD	MRPL13	0.0121955094761911	0.32
LAML	MRPL13	0.0130887118267286	0.33
LGG	MRPL13	0.0434230756516504	1
LIHC	MRPL13	3.48353503794322e-06	9.8e-05

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MRPL13	0.0335876741041149	0.94
STAD	MRPL13	0.0432465765027704	1
THCA	MRPL13	0.0324237677092673	0.94
KIRC	MRPL13	0.00962971332389101	0.31
KIRP	MRPL13	0.0271330954535922	0.81
SKCM	MRPL13	0.0380527925149711	1
UCEC	MRPL13	0.0130604277843739	0.4
THYM	MRPL13	0.00520260360674545	0.17

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0007137	Squamous cell carcinoma	1	CTD_human
C0024623	Malignant neoplasm of stomach	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human