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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS16 (NCBI Gene ID:51021)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS16
	Gene ID: 51021
	Gene Symbol	MRPS16
	Gene ID	51021
	Gene Name	mitochondrial ribosomal protein S16
	Synonyms	CGI-132\|COXPD2\|MRP-S16\|RPMS16
	Cytomap	10q22.2
	Type of Gene	protein-coding
	Description	28S ribosomal protein S16, mitochondrialS16mtmitochondrial small ribosomal subunit protein bS16m
	Modification date	20200320
	UniProtAcc	Q9Y3D3

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS16	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS16[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS16	Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation	15505824

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000372945	75011520	75011781	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000372945	75011520	75011781	2651	225	485	137	4	91

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9Y3D3	4	91	1	34	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9Y3D3	4	91	35	137	Chain	ID=PRO_0000030618;Note=28S ribosomal protein S16%2C mitochondrial
Q9Y3D3	4	91	12	12	Natural variant	ID=VAR_031525;Note=Y->H;Dbxref=dbSNP:rs7905009

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	MRPS16	-1.64208084987431	0.00239070039242506
HNSC	MRPS16	-2.01564621821803	0.00518989327406416

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	MRPS16	-0.08783165	0.007920669
BLCA	MRPS16	-0.090741037	0.022496
UCEC	MRPS16	0.110331472	0.039915334

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS16 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPS16	PSMC3	0.808006458	3.87E-12
DLBC	Cell metabolism gene	MRPS16	TIMM50	0.815769894	1.64E-12
DLBC	Epifactor	MRPS16	FBL	0.823027265	7.06E-13
DLBC	IUPHAR	MRPS16	BIRC5	0.800843043	8.26E-12
DLBC	IUPHAR	MRPS16	SLC25A3	0.808340356	3.73E-12
THYM	Cell metabolism gene	MRPS16	ALG3	0.800115423	2.09E-28
THYM	Cell metabolism gene	MRPS16	ITPA	0.800853258	1.72E-28
THYM	Cell metabolism gene	MRPS16	GALK1	0.800974759	1.66E-28
THYM	Cell metabolism gene	MRPS16	OAZ1	0.802289587	1.17E-28
THYM	Cell metabolism gene	MRPS16	PYCRL	0.802696796	1.04E-28
THYM	Cell metabolism gene	MRPS16	SLC27A5	0.803594559	8.17E-29
THYM	Cell metabolism gene	MRPS16	PSMA5	0.805203643	5.25E-29
THYM	Cell metabolism gene	MRPS16	EXOSC5	0.807011932	3.18E-29
THYM	Cell metabolism gene	MRPS16	PREB	0.807155252	3.05E-29
THYM	Cell metabolism gene	MRPS16	APRT	0.807541971	2.74E-29
THYM	Cell metabolism gene	MRPS16	CCT7	0.808957333	1.84E-29
THYM	Cell metabolism gene	MRPS16	PSMA7	0.809727681	1.48E-29
THYM	Cell metabolism gene	MRPS16	EXOSC1	0.810217948	1.29E-29
THYM	Cell metabolism gene	MRPS16	PSMB4	0.81265898	6.41E-30
THYM	Cell metabolism gene	MRPS16	PSMD8	0.81449277	3.76E-30
THYM	Cell metabolism gene	MRPS16	WBSCR22	0.814796312	3.45E-30
THYM	Cell metabolism gene	MRPS16	CCT3	0.815487041	2.81E-30
THYM	Cell metabolism gene	MRPS16	GUK1	0.818031105	1.33E-30
THYM	Cell metabolism gene	MRPS16	HMOX2	0.821899608	4.13E-31
THYM	Cell metabolism gene	MRPS16	DGUOK	0.824762447	1.71E-31
THYM	Cell metabolism gene	MRPS16	GRPEL1	0.825604011	1.32E-31
THYM	Cell metabolism gene	MRPS16	SNRPD1	0.828908344	4.64E-32
THYM	Cell metabolism gene	MRPS16	PHKG2	0.828996914	4.51E-32
THYM	Cell metabolism gene	MRPS16	UROS	0.830958707	2.40E-32
THYM	Cell metabolism gene	MRPS16	LSM3	0.832736942	1.35E-32
THYM	Cell metabolism gene	MRPS16	PSMD13	0.83393208	9.10E-33
THYM	Cell metabolism gene	MRPS16	PSMB7	0.835994131	4.59E-33
THYM	Cell metabolism gene	MRPS16	PAFAH1B3	0.837294699	2.96E-33
THYM	Cell metabolism gene	MRPS16	PSMC3	0.838348028	2.08E-33
THYM	Cell metabolism gene	MRPS16	TPI1	0.838748499	1.81E-33
THYM	Cell metabolism gene	MRPS16	SEC61G	0.838959327	1.69E-33
THYM	Cell metabolism gene	MRPS16	TIMM50	0.839746209	1.29E-33
THYM	Cell metabolism gene	MRPS16	TIMM10	0.840702363	9.27E-34
THYM	Cell metabolism gene	MRPS16	MTX1	0.84132747	7.46E-34
THYM	Cell metabolism gene	MRPS16	CYC1	0.843707228	3.25E-34
THYM	Cell metabolism gene	MRPS16	POLR3K	0.84435952	2.58E-34
THYM	Cell metabolism gene	MRPS16	FDPS	0.846542204	1.18E-34
THYM	Cell metabolism gene	MRPS16	NANS	0.848449882	5.93E-35
THYM	Cell metabolism gene	MRPS16	POLD2	0.851364799	2.03E-35
THYM	Cell metabolism gene	MRPS16	GEMIN6	0.851466725	1.95E-35
THYM	Cell metabolism gene	MRPS16	TIMM17B	0.85220023	1.48E-35
THYM	Cell metabolism gene	MRPS16	SNRPB	0.852449876	1.35E-35
THYM	Cell metabolism gene	MRPS16	SNRPD2	0.852953342	1.12E-35
THYM	Cell metabolism gene	MRPS16	PSMD4	0.85363189	8.65E-36
THYM	Cell metabolism gene	MRPS16	TSTA3	0.854287262	6.75E-36
THYM	Cell metabolism gene	MRPS16	ATP5G1	0.856573708	2.80E-36
THYM	Cell metabolism gene	MRPS16	GEMIN7	0.857736452	1.78E-36
THYM	Cell metabolism gene	MRPS16	NOP56	0.858969481	1.10E-36
THYM	Cell metabolism gene	MRPS16	PMPCA	0.860118001	6.98E-37
THYM	Cell metabolism gene	MRPS16	ATIC	0.860572757	5.82E-37
THYM	Cell metabolism gene	MRPS16	TIMM13	0.86210362	3.15E-37
THYM	Cell metabolism gene	MRPS16	LSM4	0.863110484	2.09E-37
THYM	Cell metabolism gene	MRPS16	POLR2H	0.863409545	1.85E-37
THYM	Cell metabolism gene	MRPS16	TOMM40	0.865725453	7.13E-38
THYM	Cell metabolism gene	MRPS16	ACOT8	0.866463155	5.25E-38
THYM	Cell metabolism gene	MRPS16	EXOSC4	0.866494747	5.18E-38
THYM	Cell metabolism gene	MRPS16	NME1	0.867066786	4.07E-38
THYM	Cell metabolism gene	MRPS16	PGP	0.869913116	1.21E-38
THYM	Cell metabolism gene	MRPS16	PSMB2	0.87209711	4.70E-39
THYM	Cell metabolism gene	MRPS16	HMBS	0.873169986	2.93E-39
THYM	Cell metabolism gene	MRPS16	EBP	0.874409608	1.69E-39
THYM	Cell metabolism gene	MRPS16	SNRPE	0.874628015	1.53E-39
THYM	Cell metabolism gene	MRPS16	PSMB3	0.876216535	7.49E-40
THYM	Cell metabolism gene	MRPS16	TIMM8B	0.877274201	4.62E-40
THYM	Cell metabolism gene	MRPS16	DTYMK	0.895963552	4.07E-44
THYM	CGC	MRPS16	RECQL4	0.803345349	8.74E-29
THYM	CGC	MRPS16	PRCC	0.812949541	5.89E-30
THYM	CGC	MRPS16	COX6C	0.831763937	1.85E-32
THYM	CGC	MRPS16	ATIC	0.860572757	5.82E-37
THYM	CGC	MRPS16	SDHAF2	0.869668303	1.35E-38
THYM	Epifactor	MRPS16	HDGF	0.802302955	1.16E-28
THYM	Epifactor	MRPS16	SIRT6	0.803003995	9.59E-29
THYM	Epifactor	MRPS16	RRP8	0.804854763	5.78E-29
THYM	Epifactor	MRPS16	EXOSC5	0.807011932	3.18E-29
THYM	Epifactor	MRPS16	EXOSC1	0.810217948	1.29E-29
THYM	Epifactor	MRPS16	TAF10	0.813806165	4.60E-30
THYM	Epifactor	MRPS16	NAP1L4	0.819486747	8.58E-31
THYM	Epifactor	MRPS16	RUVBL2	0.824638878	1.78E-31
THYM	Epifactor	MRPS16	VPS72	0.824880105	1.65E-31
THYM	Epifactor	MRPS16	PPM1G	0.849323828	4.31E-35
THYM	Epifactor	MRPS16	PPP4C	0.856757425	2.61E-36
THYM	Epifactor	MRPS16	EXOSC4	0.866494747	5.18E-38
THYM	Epifactor	MRPS16	BRMS1	0.867743835	3.06E-38
THYM	Epifactor	MRPS16	CDK5	0.870300141	1.03E-38
THYM	IUPHAR	MRPS16	SIRT6	0.803003995	9.59E-29
THYM	IUPHAR	MRPS16	SLC27A5	0.803594559	8.17E-29
THYM	IUPHAR	MRPS16	STK16	0.808026293	2.39E-29
THYM	IUPHAR	MRPS16	MFSD2B	0.811171212	9.82E-30
THYM	IUPHAR	MRPS16	MTCH2	0.818610545	1.12E-30
THYM	IUPHAR	MRPS16	HMOX2	0.821899608	4.13E-31
THYM	IUPHAR	MRPS16	UCHL3	0.822794462	3.14E-31
THYM	IUPHAR	MRPS16	PHKG2	0.828996914	4.51E-32
THYM	IUPHAR	MRPS16	USP5	0.841432763	7.20E-34
THYM	IUPHAR	MRPS16	FDPS	0.846542204	1.18E-34
THYM	IUPHAR	MRPS16	ECE2	0.862745606	2.43E-37
THYM	IUPHAR	MRPS16	CDK5	0.870300141	1.03E-38
THYM	IUPHAR	MRPS16	PSMB2	0.87209711	4.70E-39
THYM	Kinase	MRPS16	STK16	0.808026293	2.39E-29
THYM	Kinase	MRPS16	PHKG2	0.828996914	4.51E-32
THYM	Kinase	MRPS16	ADCK4	0.832389714	1.51E-32
THYM	Kinase	MRPS16	CDK5	0.870300141	1.03E-38
THYM	TF	MRPS16	PREB	0.807155252	3.05E-29
THYM	TF	MRPS16	ZNF688	0.814620648	3.63E-30
THYM	TF	MRPS16	ZNF668	0.817022918	1.79E-30
THYM	TF	MRPS16	USF1	0.832087811	1.67E-32
THYM	TSG	MRPS16	TSSC4	0.80236819	1.14E-28
THYM	TSG	MRPS16	SIRT6	0.803003995	9.59E-29
THYM	TSG	MRPS16	MYO1A	0.810730474	1.11E-29
THYM	TSG	MRPS16	ZNF668	0.817022918	1.79E-30
THYM	TSG	MRPS16	RTN4IP1	0.831809506	1.82E-32
THYM	TSG	MRPS16	NME1	0.867066786	4.07E-38
THYM	TSG	MRPS16	BRMS1	0.867743835	3.06E-38
UCS	Cell metabolism gene	MRPS16	ALG3	0.800115423	2.09E-28
UCS	Cell metabolism gene	MRPS16	ITPA	0.800853258	1.72E-28
UCS	Cell metabolism gene	MRPS16	GALK1	0.800974759	1.66E-28
UCS	Cell metabolism gene	MRPS16	OAZ1	0.802289587	1.17E-28
UCS	Cell metabolism gene	MRPS16	PYCRL	0.802696796	1.04E-28
UCS	Cell metabolism gene	MRPS16	SLC27A5	0.803594559	8.17E-29
UCS	Cell metabolism gene	MRPS16	PSMA5	0.805203643	5.25E-29
UCS	Cell metabolism gene	MRPS16	EXOSC5	0.807011932	3.18E-29
UCS	Cell metabolism gene	MRPS16	PREB	0.807155252	3.05E-29
UCS	Cell metabolism gene	MRPS16	APRT	0.807541971	2.74E-29
UCS	Cell metabolism gene	MRPS16	CCT7	0.808957333	1.84E-29
UCS	Cell metabolism gene	MRPS16	PSMA7	0.809727681	1.48E-29
UCS	Cell metabolism gene	MRPS16	EXOSC1	0.810217948	1.29E-29
UCS	Cell metabolism gene	MRPS16	PSMB4	0.81265898	6.41E-30
UCS	Cell metabolism gene	MRPS16	PSMD8	0.81449277	3.76E-30
UCS	Cell metabolism gene	MRPS16	WBSCR22	0.814796312	3.45E-30
UCS	Cell metabolism gene	MRPS16	CCT3	0.815487041	2.81E-30
UCS	Cell metabolism gene	MRPS16	GUK1	0.818031105	1.33E-30
UCS	Cell metabolism gene	MRPS16	HMOX2	0.821899608	4.13E-31
UCS	Cell metabolism gene	MRPS16	DGUOK	0.824762447	1.71E-31
UCS	Cell metabolism gene	MRPS16	GRPEL1	0.825604011	1.32E-31
UCS	Cell metabolism gene	MRPS16	SNRPD1	0.828908344	4.64E-32
UCS	Cell metabolism gene	MRPS16	PHKG2	0.828996914	4.51E-32
UCS	Cell metabolism gene	MRPS16	UROS	0.830958707	2.40E-32
UCS	Cell metabolism gene	MRPS16	LSM3	0.832736942	1.35E-32
UCS	Cell metabolism gene	MRPS16	PSMD13	0.83393208	9.10E-33
UCS	Cell metabolism gene	MRPS16	PSMB7	0.835994131	4.59E-33
UCS	Cell metabolism gene	MRPS16	PAFAH1B3	0.837294699	2.96E-33
UCS	Cell metabolism gene	MRPS16	PSMC3	0.838348028	2.08E-33
UCS	Cell metabolism gene	MRPS16	TPI1	0.838748499	1.81E-33
UCS	Cell metabolism gene	MRPS16	SEC61G	0.838959327	1.69E-33
UCS	Cell metabolism gene	MRPS16	TIMM50	0.839746209	1.29E-33
UCS	Cell metabolism gene	MRPS16	TIMM10	0.840702363	9.27E-34
UCS	Cell metabolism gene	MRPS16	MTX1	0.84132747	7.46E-34
UCS	Cell metabolism gene	MRPS16	CYC1	0.843707228	3.25E-34
UCS	Cell metabolism gene	MRPS16	POLR3K	0.84435952	2.58E-34
UCS	Cell metabolism gene	MRPS16	FDPS	0.846542204	1.18E-34
UCS	Cell metabolism gene	MRPS16	NANS	0.848449882	5.93E-35
UCS	Cell metabolism gene	MRPS16	POLD2	0.851364799	2.03E-35
UCS	Cell metabolism gene	MRPS16	GEMIN6	0.851466725	1.95E-35
UCS	Cell metabolism gene	MRPS16	TIMM17B	0.85220023	1.48E-35
UCS	Cell metabolism gene	MRPS16	SNRPB	0.852449876	1.35E-35
UCS	Cell metabolism gene	MRPS16	SNRPD2	0.852953342	1.12E-35
UCS	Cell metabolism gene	MRPS16	PSMD4	0.85363189	8.65E-36
UCS	Cell metabolism gene	MRPS16	TSTA3	0.854287262	6.75E-36
UCS	Cell metabolism gene	MRPS16	ATP5G1	0.856573708	2.80E-36
UCS	Cell metabolism gene	MRPS16	GEMIN7	0.857736452	1.78E-36
UCS	Cell metabolism gene	MRPS16	NOP56	0.858969481	1.10E-36
UCS	Cell metabolism gene	MRPS16	PMPCA	0.860118001	6.98E-37
UCS	Cell metabolism gene	MRPS16	ATIC	0.860572757	5.82E-37
UCS	Cell metabolism gene	MRPS16	TIMM13	0.86210362	3.15E-37
UCS	Cell metabolism gene	MRPS16	LSM4	0.863110484	2.09E-37
UCS	Cell metabolism gene	MRPS16	POLR2H	0.863409545	1.85E-37
UCS	Cell metabolism gene	MRPS16	TOMM40	0.865725453	7.13E-38
UCS	Cell metabolism gene	MRPS16	ACOT8	0.866463155	5.25E-38
UCS	Cell metabolism gene	MRPS16	EXOSC4	0.866494747	5.18E-38
UCS	Cell metabolism gene	MRPS16	NME1	0.867066786	4.07E-38
UCS	Cell metabolism gene	MRPS16	PGP	0.869913116	1.21E-38
UCS	Cell metabolism gene	MRPS16	PSMB2	0.87209711	4.70E-39
UCS	Cell metabolism gene	MRPS16	HMBS	0.873169986	2.93E-39
UCS	Cell metabolism gene	MRPS16	EBP	0.874409608	1.69E-39
UCS	Cell metabolism gene	MRPS16	SNRPE	0.874628015	1.53E-39
UCS	Cell metabolism gene	MRPS16	PSMB3	0.876216535	7.49E-40
UCS	Cell metabolism gene	MRPS16	TIMM8B	0.877274201	4.62E-40
UCS	Cell metabolism gene	MRPS16	DTYMK	0.895963552	4.07E-44
UCS	CGC	MRPS16	RECQL4	0.803345349	8.74E-29
UCS	CGC	MRPS16	PRCC	0.812949541	5.89E-30
UCS	CGC	MRPS16	COX6C	0.831763937	1.85E-32
UCS	CGC	MRPS16	ATIC	0.860572757	5.82E-37
UCS	CGC	MRPS16	SDHAF2	0.869668303	1.35E-38
UCS	Epifactor	MRPS16	HDGF	0.802302955	1.16E-28
UCS	Epifactor	MRPS16	SIRT6	0.803003995	9.59E-29
UCS	Epifactor	MRPS16	RRP8	0.804854763	5.78E-29
UCS	Epifactor	MRPS16	EXOSC5	0.807011932	3.18E-29
UCS	Epifactor	MRPS16	EXOSC1	0.810217948	1.29E-29
UCS	Epifactor	MRPS16	TAF10	0.813806165	4.60E-30
UCS	Epifactor	MRPS16	NAP1L4	0.819486747	8.58E-31
UCS	Epifactor	MRPS16	RUVBL2	0.824638878	1.78E-31
UCS	Epifactor	MRPS16	VPS72	0.824880105	1.65E-31
UCS	Epifactor	MRPS16	PPM1G	0.849323828	4.31E-35
UCS	Epifactor	MRPS16	PPP4C	0.856757425	2.61E-36
UCS	Epifactor	MRPS16	EXOSC4	0.866494747	5.18E-38
UCS	Epifactor	MRPS16	BRMS1	0.867743835	3.06E-38
UCS	Epifactor	MRPS16	CDK5	0.870300141	1.03E-38
UCS	IUPHAR	MRPS16	SIRT6	0.803003995	9.59E-29
UCS	IUPHAR	MRPS16	SLC27A5	0.803594559	8.17E-29
UCS	IUPHAR	MRPS16	STK16	0.808026293	2.39E-29
UCS	IUPHAR	MRPS16	MFSD2B	0.811171212	9.82E-30
UCS	IUPHAR	MRPS16	MTCH2	0.818610545	1.12E-30
UCS	IUPHAR	MRPS16	HMOX2	0.821899608	4.13E-31
UCS	IUPHAR	MRPS16	UCHL3	0.822794462	3.14E-31
UCS	IUPHAR	MRPS16	PHKG2	0.828996914	4.51E-32
UCS	IUPHAR	MRPS16	USP5	0.841432763	7.20E-34
UCS	IUPHAR	MRPS16	FDPS	0.846542204	1.18E-34
UCS	IUPHAR	MRPS16	ECE2	0.862745606	2.43E-37
UCS	IUPHAR	MRPS16	CDK5	0.870300141	1.03E-38
UCS	IUPHAR	MRPS16	PSMB2	0.87209711	4.70E-39
UCS	Kinase	MRPS16	STK16	0.808026293	2.39E-29
UCS	Kinase	MRPS16	PHKG2	0.828996914	4.51E-32
UCS	Kinase	MRPS16	ADCK4	0.832389714	1.51E-32
UCS	Kinase	MRPS16	CDK5	0.870300141	1.03E-38
UCS	TF	MRPS16	PREB	0.807155252	3.05E-29
UCS	TF	MRPS16	ZNF688	0.814620648	3.63E-30
UCS	TF	MRPS16	ZNF668	0.817022918	1.79E-30
UCS	TF	MRPS16	USF1	0.832087811	1.67E-32
UCS	TSG	MRPS16	TSSC4	0.80236819	1.14E-28
UCS	TSG	MRPS16	SIRT6	0.803003995	9.59E-29
UCS	TSG	MRPS16	MYO1A	0.810730474	1.11E-29
UCS	TSG	MRPS16	ZNF668	0.817022918	1.79E-30
UCS	TSG	MRPS16	RTN4IP1	0.831809506	1.82E-32
UCS	TSG	MRPS16	NME1	0.867066786	4.07E-38
UCS	TSG	MRPS16	BRMS1	0.867743835	3.06E-38

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	MRPS16	MRPS12	2.11566333114824	0.000125885009765625
BRCA	MRPS16	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS16	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MRPS16	MRPS7	1.27029395477208	0.00182077236082954
KIRC	MRPS16	MRPS15	1.11572283836012	0.00361818577801855
ESCA	MRPS16	MRPS12	-1.86248549814506	0.0048828125
PRAD	MRPS16	MRPS9	1.04379115553269	0.00496210155254694
CHOL	MRPS16	MRPS6	2.57097392409939	0.0078125
KICH	MRPS16	MRPS2	1.26543989555015	0.0114533305168152
LUSC	MRPS16	MRPS6	-1.26158810839259	0.013873001943322
THCA	MRPS16	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MRPS16	MRPS5	-2.15440118747854	0.0185546875
ESCA	MRPS16	MRPS2	-3.20556788084675	0.0244140625
HNSC	MRPS16	MRPS12	1.33677139927136	0.0248336488591576
THCA	MRPS16	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS16	MRPS11	-2.30276998968219	0.040130615234375
LUAD	MRPS16	MRPS12	-5.3399185683719	1.00823612619819e-08
THCA	MRPS16	MRPS10	1.33413691764991	1.55171507174296e-05
BRCA	MRPS16	MRPS12	-1.59537235222597	1.66215672512325e-20
LUAD	MRPS16	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS16	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPS16	MRPS2	-2.70930846488508	1.92864354932136e-09
LUAD	MRPS16	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRPS16	MRPS11	-1.24304977976804	2.31302509538916e-07
LIHC	MRPS16	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MRPS16	MRPS12	1.48941080926405	3.19480895996094e-05
PRAD	MRPS16	MRPS6	1.00673230965164	3.48152859299693e-07
LUAD	MRPS16	MRPS14	-3.02634914022647	4.24616078981701e-06
LIHC	MRPS16	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	MRPS16	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS16	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MRPS16	MRPS11	-2.9004097541444	5.43966600483641e-07
LUSC	MRPS16	MRPS14	-3.86726163364221	6.1453992201761e-05
KICH	MRPS16	MRPS6	-1.34376231922276	7.49826431274414e-05
BRCA	MRPS16	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS16

ICT1, ELAVL1, ZP3, CAND1, ATXN10, MRPS2, MRPS9, MRPS26, MRPS25, MCAT, SLC25A5, HNRNPU, FAM50B, SSBP1, PSMC1, PSMA5, HNRNPDL, PSMC2, HNRNPR, MPV17, PSMA7, CEP76, TRMT10B, PSMD7, Naa50, COQ4, ADCK3, FAM136A, CDC14B, DUSP11, SBF1, MRPS34, MRPS27, RRS1, AARS2, GEMIN4, LEO1, MRPL22, PITRM1, ZNF830, EFTUD2, HEXIM1, MEPCE, LARP7, RECQL4, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H1, TCF7L2, ALYREF, SNRNP70, FBXW8, CCDC8, OBSL1, CUL9, PLEKHA4, ZC3H18, ESR1, IMMP2L, PRKAG2, GRSF1, ZC3HAV1, IGF2BP2, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, COX15, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLIRP, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, MKI67, CLPP, NINL, DNAJC19, HSCB, MRPS23, MRPS31, MRPS14, MRPS24, UFL1, DDRGK1, COX8A, PDHA1, USP15, FZR1, MAP4K1, MAP4K3, MRPS18B, MRPS18C, MRPS17, ZNF346, SURF6, RPL10, MRPS11, MRPS15, LIN28A, ZC3H3, H1FNT, APOBEC3D, ABT1, MRPS6, ZNF574, MRPL2, PRR3, ERAL1, NOG, RPL7A, KLF12, SOX15, TLX2, KLF15, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPS16	chr10	75009107	T	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS16	chr10	75009316	CAAG	C	Deletion	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS16	chr10	75009753	CAGG	C	Deletion	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS16	chr10	75009976	C	CA	Duplication	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS16	chr10	75010159	AG	A	Deletion	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS16	chr10	75010597	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS16	chr10	75010635	G	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75010644	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75010680	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75010692	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75010693	G	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_2	SO:0001587\|nonsense	SO:0001587\|nonsense
MRPS16	chr10	75010712	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75010724	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75010748	AC	A	Deletion	Pathogenic	not_provided
MRPS16	chr10	75010754	A	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75010902	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75010996	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011046	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011300	AT	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011309	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011455	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011660	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75011683	G	T	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75011699	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75011726	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75011729	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75011732	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75011736	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75011757	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75011761	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS16	chr10	75011774	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS16	chr10	75011784	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011793	C	T	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75011942	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75012122	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75012216	C	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS16	chr10	75012248	C	G	single_nucleotide_variant	Benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MRPS16	chr10	75012253	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MRPS16	chr10	75012321	AAC	A	Microsatellite	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MRPS16	chr10	75012335	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MRPS16	chr10	75012343	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MRPS16	chr10	75012357	ACCG	A	Deletion	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MRPS16	chr10	75012423	T	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency
MRPS16	chr10	75012466	C	T	single_nucleotide_variant	Likely_benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS16	BLCA	chr10	75011600	75011600	G	C	Silent	p.L65L	4
MRPS16	BLCA	chr10	75011600	75011600	G	C	Silent		2
MRPS16	LUAD	chr10	75010727	75010727	C	A	Silent	p.L99L	2
MRPS16	CHOL	chr10	75011619	75011619	T	G	Missense_Mutation		2
MRPS16	LUAD	chr10	75011685	75011685	G	C	Missense_Mutation	p.A37G	2
MRPS16	CHOL	chr10	75011619	75011619	T	G	Missense_Mutation	p.N59T	2
MRPS16	LIHC	chr10	75010634	75010634	T	C	Silent	p.T130T	1
MRPS16	LUAD	chr10	75011591	75011591	G	C	Silent	p.L68L	1
MRPS16	CHOL	chr10	75006528	75006528	T	C	Missense_Mutation		1
MRPS16	READ	chr10	75011736	75011736	C	T	Missense_Mutation	p.R20H	1
MRPS16	COAD	chr10	75010681	75010681	C	T	Missense_Mutation	p.A115T	1
MRPS16	THCA	chr10	75011557	75011557	C	A	Missense_Mutation		1
MRPS16	COAD	chr10	75010702	75010702	C	T	Missense_Mutation	p.E108K	1
MRPS16	HNSC	chr10	75011546	75011546	G	C	Silent		1
MRPS16	HNSC	chr10	75011546	75011546	G	C	Silent	p.L83L	1
MRPS16	LIHC	chr10	75010748	75010748	A	G	Silent		1
MRPS16	LIHC	chr10	75010617	75010617	T	C	Missense_Mutation		1

Copy number variation (CNV) of MRPS16
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS16
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
86486	N/A	BU679813	DNAJC9-AS1	chr10	75010629	+	MRPS16	chr10	75010732	-
86486	LIHC	TCGA-DD-AADN-01A	ECD	chr10	74894361	-	MRPS16	chr10	75010749	-
86486	N/A	CF144815	IFI30	chr19	18285675	-	MRPS16	chr10	75009992	-
95355	N/A	BM013703	MRPS16	chr10	75008607	-	FAM149B1	chr10	74962227	-
60822	N/A	CB048514	MRPS16	chr10	75008601	-	NUDT13	chr10	74882673	-
92156	N/A	AA601157	MRPS16	chr10	75009742	-	P4HA1	chr10	74808304	-
95094	N/A	BQ014524	MRPS16	chr10	75010662	-	S100A11	chr1	152009409	-
102141	N/A	CF144818	MRPS16	chr10	75009717	-	SACS	chr13	23942966	+
68145	BLCA	TCGA-XF-A9ST	MRPS16	chr10	75010573	-	TTC18	chr10	75016174	-
68145	BLCA	TCGA-XF-A9ST	MRPS16	chr10	75010596	-	TTC18	chr10	75016174	-
68145	BLCA	TCGA-XF-A9ST	MRPS16	chr10	75010683	-	TTC18	chr10	75016175	-
68145	BLCA	TCGA-XF-A9ST	MRPS16	chr10	75011521	-	TTC18	chr10	75016174	-
68145	BRCA	TCGA-A8-A07W-01A	MRPS16	chr10	75010681	-	TTC18	chr10	75016173	-
68145	COAD	TCGA-AA-A00K-01A	MRPS16	chr10	75010567	-	TTC18	chr10	75016174	-
86486	N/A	CF122943	PDZD8	chr10	119104430	+	MRPS16	chr10	75009681	-
86492	STAD	TCGA-HU-8238-01A	SRPK1	chr6	35810312	-	MRPS16	chr10	75009076	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	MRPS16	0.000416019509473614	0.012

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPS16	0.00297993596123991	0.089
THCA	MRPS16	1.51226883669031e-05	5e-04
KIRC	MRPS16	0.00733384520021056	0.21
LGG	MRPS16	0.000299949304254064	0.0096
PAAD	MRPS16	0.0183500235895829	0.51
SKCM	MRPS16	0.00143829475042053	0.045
THYM	MRPS16	0.0277616658329352	0.75

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1864843	Combined Oxidative Phosphorylation Deficiency 2	4	CTD_human;GENOMICS_ENGLAND;ORPHANET