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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MRPS33 (NCBI Gene ID:51650)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MRPS33
Gene ID: 51650
Gene Symbol

MRPS33

Gene ID

51650

Gene Namemitochondrial ribosomal protein S33
SynonymsCGI-139|MRP-S33|PTD003|S33mt
Cytomap

7q34

Type of Geneprotein-coding
Description28S ribosomal protein S33, mitochondrialmitochondrial small ribosomal subunit protein mS33
Modification date20200313
UniProtAcc

Q9Y291


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0005840Ribosome
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS33(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'MRPS33[title] AND translation [title] AND human.'
GeneTitlePMID
MRPS33..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000003247871407102181407104603UTR-3CDS
ENST000004969581407102181407104603UTR-3CDS

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
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check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
BRCAMRPS33-2.503674235762720.000154377851145473
LUSCMRPS33-3.327026699718655.71093314566242e-07


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
SARCMRPS330.4322351260.000167654
BLCAMRPS33-0.0720899750.005176046
LGGMRPS330.0912375670.049320517

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MRPS33 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
GBMCell metabolism geneMRPS33PSMC20.8065177171.19E-40
GBMEpifactorMRPS33ZNHIT10.8363944872.97E-46
KICHCell metabolism geneMRPS33PMPCB0.8143379839.64E-23
LAMLCell metabolism geneMRPS33LSM50.8083664833.35E-41
THCACell metabolism geneMRPS33ATP5G10.8156113381.47E-137
THYMCell metabolism geneMRPS33PSMB40.8049909765.57E-29
THYMCell metabolism geneMRPS33TBCA0.8055342744.79E-29
THYMCell metabolism geneMRPS33FH0.8202752886.77E-31
THYMCell metabolism geneMRPS33CYC10.8250988371.54E-31
THYMCGCMRPS33COX6C0.8028067791.01E-28
THYMCGCMRPS33FH0.8202752886.77E-31
THYMTSGMRPS33FH0.8202752886.77E-31
UCSCell metabolism geneMRPS33PSMB40.8049909765.57E-29
UCSCell metabolism geneMRPS33TBCA0.8055342744.79E-29
UCSCell metabolism geneMRPS33FH0.8202752886.77E-31
UCSCell metabolism geneMRPS33CYC10.8250988371.54E-31
UCSCGCMRPS33COX6C0.8028067791.01E-28
UCSCGCMRPS33FH0.8202752886.77E-31
UCSTSGMRPS33FH0.8202752886.77E-31


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
LIHCMRPS33MRPS31-1.075652322561630.000180054839259286
BRCAMRPS33MRPS15-2.195675516823180.000188684660674703
KICHMRPS33MRPS51.251082878384370.000249803066253662
HNSCMRPS33MRPS23-1.648501182419920.0007221434505027
THCAMRPS33MRPS231.866400512816150.000772056397653126
KIRCMRPS33MRPS18B-1.089993480106740.00208385211535325
LIHCMRPS33MRPS18C-1.253360420466980.00251545393492315
LUSCMRPS33MRPS21-1.067382108984510.00291962754379891
COADMRPS33MRPS18C-3.485058302403650.00322914123535157
LUADMRPS33MRPS311.581409157004420.00351308111790755
KIRCMRPS33MRPS151.115722838360120.00361818577801855
CHOLMRPS33MRPS23-3.475072171657320.00390625
CHOLMRPS33MRPS18B-1.343419614730830.0078125
KICHMRPS33MRPS21.265439895550150.0114533305168152
THCAMRPS33MRPS15-1.199606024229950.0140154883942907
KICHMRPS33MRPS31-1.441716135774950.0173123478889465
BLCAMRPS33MRPS18B-2.793162037050830.0180816650390625
ESCAMRPS33MRPS5-2.154401187478540.0185546875
LUADMRPS33MRPS18B-2.591326042841760.0228310323601027
ESCAMRPS33MRPS2-3.205567880846750.0244140625
THCAMRPS33MRPS11-3.106947285409620.0252226935182201
COADMRPS33MRPS311.259306100836780.0253507494926453
STADMRPS33MRPS18B-2.187838450614950.0341199110262096
BLCAMRPS33MRPS11-2.302769989682190.040130615234375
KIRPMRPS33MRPS21-1.889331025219320.0413399673998356
BLCAMRPS33MRPS31-1.749897165816380.0445594787597656
BRCAMRPS33MRPS21-1.819757862910871.52500483244108e-06
LIHCMRPS33MRPS23-3.605472667898871.76596269781643e-07
LUADMRPS33MRPS5-2.208819458859271.77904381378076e-06
LUSCMRPS33MRPS2-2.709308464885081.92864354932136e-09
BRCAMRPS33MRPS11-1.243049779768042.31302509538916e-07
LUADMRPS33MRPL42-6.346102496024912.48255276366547e-08
LUADMRPS33MRPS21-2.128285416554244.20890892730867e-05
LIHCMRPS33MRPS2-1.147710553588284.2584580238307e-05
LUSCMRPS33MRPS5-7.659563899623194.27210217182982e-06
KIRCMRPS33MRPL42-4.3820953362485.26630854166927e-06
LUSCMRPS33MRPS11-2.90040975414445.43966600483641e-07
PRADMRPS33MRPS311.428780089783386.76861513404814e-05
THCAMRPS33MRPS31-1.557598099332116.91106419786075e-09
KIRCMRPS33MRPS31-4.325410042408659.31897250092369e-08


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MRPS33
NOL12, RPL13, TRA2A, RPL6, MRPS2, ZC3H3, RPS8, TRMT10B, ZNF707, MRPS31, MRPS5, HNRNPU, CDKN2AIP, CISD3, CDC14B, MRPS34, MRPS27, MRPS15, MRPS11, PDGFB, AURKAIP1, ZNF169, E4F1, RPL18, ZBTB48, RBM42, SNRNP70, EFTUD2, MEPCE, LARP7, RECQL4, MRM1, HSPD1, PDK1, TRMT61B, TCF7L2, CUL9, ZC3H18, FGFR1, PTPRR, SNCA, SRC, XPC, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, GRSF1, HINT2, ICT1, LONP1, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD3, RPUSD4, SLIRP, SSBP1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, ORF4a, HSCB, MAP4K3, LIN28B, YBX1, RPL26, MRPS18B, RPL17, ABT1, RBMS2, MRPS17, GLI4, SRSF3, ZNF460, RPS9, H1FNT, MRPS18C, MRPS23, HNRNPR, SRSF6, MRPS6, MRPS25, MCAT, RBM47, GLTSCR2, MRPS7, RPL4, APOBEC3D, MRPL2, MRPL18, MED17, CBX6, RPL10, SRP14, MRPS24, RPL23A, HIST1H2AM, MRPS9, RPL35, ZNF574, SRSF7, NEIL1, RPL36AL, KLF12,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MRPS33UCSchr7140710232140710232GTMissense_Mutationp.L68I3
MRPS33ESCAchr7140710420140710420GAMissense_Mutationp.S5L3
MRPS33PAADchr7140710243140710243GAMissense_Mutationp.T64M3
MRPS33SKCMchr7140710239140710239GASilentp.L65L2
MRPS33UCECchr7140710251140710251GTSilentp.L612
MRPS33LIHCchr7140710231140710231AGMissense_Mutation2
MRPS33LIHCchr7140710338140710338TCSilent2
MRPS33BRCAchr7140706249140706249CGMissense_Mutationp.R101T2
MRPS33CESCchr7140710384140710384CTMissense_Mutation2
MRPS33LIHCchr7140710338140710338TCSilentp.K32K2
MRPS33STADchr7140706259140706259CTMissense_Mutationp.E98K2
MRPS33STADchr7140706300140706300CTMissense_Mutationp.R84Q2
MRPS33ESCAchr7140710420140710420GAMissense_Mutation2
MRPS33PAADchr7140710243140710243GAMissense_Mutation2
MRPS33UCECchr7140706286140706286GTMissense_Mutationp.R89S2
MRPS33KIRCchr7140710230140710230ACSilentp.L68L1
MRPS33SKCMchr7140710238140710238GANonsense_Mutationp.R66X1
MRPS33UCSchr7140710232140710232GTMissense_Mutation1
MRPS33SKCMchr7140706242140706242TCSilentp.A103A1
MRPS33LIHCchr7140710383140710383CTSilent1
MRPS33SKCMchr7140710238140710238GANonsense_Mutationp.R66*1
MRPS33COADchr7140710260140710260GASilentp.Y58Y1
MRPS33LIHCchr7140710231140710231AGMissense_Mutationp.L68P1
MRPS33LIHCchr7140706238140706238T-Frame_Shift_Delp.R105fs1
MRPS33THYMchr7140710358140710358TCMissense_Mutation1
MRPS33LIHCchr7140710377140710377A-Frame_Shift_Delp.F19fs1
MRPS33UCECchr7140706271140706271GAMissense_Mutationp.P94S1
MRPS33HNSCchr7140710224140710224GCSilent1
MRPS33MESOchr7140710412140710412CAMissense_Mutation1
MRPS33UCECchr7140710370140710370C-Frame_Shift_Delp.V22fs1
MRPS33HNSCchr7140710224140710224GCSilentp.L70L1
MRPS33UCECchr7140706250140706250T-Frame_Shift_Delp.R101fs1
MRPS33KIRCchr7140710333140710333A-Frame_Shift_Delp.V34fs1

check buttonCopy number variation (CNV) of MRPS33
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MRPS33
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
54117BLCATCGA-K4-A3WV-01ABRAFchr7140624366-MRPS33chr7140706335-
54117BLCATCGA-K4-A3WV-01ABRAFchr7140624366-MRPS33chr7140710460-
54117N/ABE835337CTNNB1chr341281235+MRPS33chr7140706183-
54117PRADTCGA-YJ-A8SW-01ALUC7L2chr7139060902+MRPS33chr7140710460-
54121OVTCGA-36-1577MKRN1chr7140178959-MRPS33chr7140706335-
54121OVTCGA-36-1577MKRN1chr7140178959-MRPS33chr7140710460-
54121OVTCGA-36-1577-01AMKRN1chr7140178960-MRPS33chr7140706335-
54121OVTCGA-36-1577-01AMKRN1chr7140178960-MRPS33chr7140710417-
54121OVTCGA-36-1577-01AMKRN1chr7140178960-MRPS33chr7140710460-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LIHCMRPS330.0001749855731744830.0047
KIRPMRPS330.0005810593021095620.015
KIRCMRPS336.46745378341243e-060.00018

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LUADMRPS330.04035834953770161
LUSCMRPS330.0003908459618746950.013
LGGMRPS333.5391101600289e-081.2e-06
PCPGMRPS330.004190120788873360.13
SARCMRPS330.0313603224997540.94

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0005586Bipolar Disorder1CTD_human
C0005587Depression, Bipolar1CTD_human
C0024713Manic Disorder1CTD_human
C0338831Manic1CTD_human