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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CDK5RAP1 (NCBI Gene ID:51654)

Gene Summary

Gene Summary

Gene Information	Gene Name: CDK5RAP1
	Gene ID: 51654
	Gene Symbol	CDK5RAP1
	Gene ID	51654
	Gene Name	CDK5 regulatory subunit associated protein 1
	Synonyms	C20orf34\|C42\|CGI-05\|HSPC167
	Cytomap	20q11.21
	Type of Gene	protein-coding
	Description	CDK5 regulatory subunit-associated protein 1CDK5 activator-binding protein C42
	Modification date	20200313
	UniProtAcc	Q96SZ6

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK5RAP1	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	11882646

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CDK5RAP1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'CDK5RAP1[title] AND translation [title] AND human.'

Gene	Title	PMID
CDK5RAP1	Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans	25738458

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000357886	31948156	31948297	In-frame
ENST00000357886	31958304	31958435	Frame-shift
ENST00000357886	31960447	31960503	Frame-shift
ENST00000357886	31971285	31971327	In-frame
ENST00000357886	31975128	31975339	Frame-shift
ENST00000357886	31981837	31981872	Frame-shift
ENST00000357886	31982818	31982922	Frame-shift
ENST00000357886	31984566	31984890	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000357886	31948156	31948297	2181	1739	1879	601	528	575
ENST00000357886	31971285	31971327	2181	1031	1072	601	292	306

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	CDK5RAP1	-2.23793302914222	0.0009765625
LUAD	CDK5RAP1	-4.21683270226742	1.08875420407917e-07
LUSC	CDK5RAP1	-3.17888161583003	1.12587271987372e-05
BRCA	CDK5RAP1	-2.63965887905737	3.76758675610252e-06
STAD	CDK5RAP1	-1.37355475632562	4.09781932830811e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
READ	CDK5RAP1	2	1	0.0457513229263509	0.251972222222222	0.145860126582278	0.00265299287569629	0.183185388562696
THYM	CDK5RAP1	2	1	0.0440368710658852	0.38415652173913	0.158931818181818	0.878975537160579	0.560550635973636

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	CDK5RAP1	0.110433397	0.033960075
DLBC	CDK5RAP1	-0.044936987	0.038290811
SKCM	CDK5RAP1	-0.073155629	0.049297854

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CDK5RAP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	CDK5RAP1	RAE1	0.802206676	3.12E-75
COAD	Cell metabolism gene	CDK5RAP1	NFS1	0.803877508	9.05E-76
COAD	Cell metabolism gene	CDK5RAP1	DPM1	0.806192744	1.60E-76
COAD	Epifactor	CDK5RAP1	ACTR5	0.839901643	8.53E-89
DLBC	Cell metabolism gene	CDK5RAP1	NOP56	0.821676643	8.28E-13
READ	Cell metabolism gene	CDK5RAP1	MOCS3	0.801230836	1.04E-24
READ	Cell metabolism gene	CDK5RAP1	AHCY	0.81550897	3.29E-26
READ	Cell metabolism gene	CDK5RAP1	NFS1	0.81553213	3.27E-26
READ	Cell metabolism gene	CDK5RAP1	RAE1	0.840171825	3.95E-29
READ	Epifactor	CDK5RAP1	ACTR5	0.826859808	1.70E-27
READ	IUPHAR	CDK5RAP1	AHCY	0.81550897	3.29E-26
THYM	Cell metabolism gene	CDK5RAP1	TIMM8B	0.801820058	1.32E-28
THYM	Cell metabolism gene	CDK5RAP1	PHKG2	0.802911265	9.84E-29
THYM	Cell metabolism gene	CDK5RAP1	PSME2	0.80326997	8.92E-29
THYM	Cell metabolism gene	CDK5RAP1	TIMM17B	0.804352592	6.63E-29
THYM	Cell metabolism gene	CDK5RAP1	PFDN4	0.804884228	5.73E-29
THYM	Cell metabolism gene	CDK5RAP1	ITPA	0.808171324	2.30E-29
THYM	Cell metabolism gene	CDK5RAP1	PSMD4	0.810984506	1.04E-29
THYM	Cell metabolism gene	CDK5RAP1	POLR2I	0.811068518	1.01E-29
THYM	Cell metabolism gene	CDK5RAP1	SNRPD2	0.813643566	4.82E-30
THYM	Cell metabolism gene	CDK5RAP1	PSMB7	0.814377896	3.89E-30
THYM	Cell metabolism gene	CDK5RAP1	HSD17B10	0.815375466	2.91E-30
THYM	Cell metabolism gene	CDK5RAP1	PSMC1	0.821665686	4.44E-31
THYM	Cell metabolism gene	CDK5RAP1	TIMM50	0.825074492	1.55E-31
THYM	Cell metabolism gene	CDK5RAP1	PSMB3	0.828122596	5.96E-32
THYM	Cell metabolism gene	CDK5RAP1	TOMM40	0.829215746	4.21E-32
THYM	Cell metabolism gene	CDK5RAP1	ACOT8	0.832764079	1.34E-32
THYM	Cell metabolism gene	CDK5RAP1	EBP	0.832831154	1.31E-32
THYM	Epifactor	CDK5RAP1	PRPF31	0.80828289	2.23E-29
THYM	Epifactor	CDK5RAP1	BRMS1	0.809792113	1.45E-29
THYM	Epifactor	CDK5RAP1	ZNHIT1	0.811499611	8.94E-30
THYM	Epifactor	CDK5RAP1	SIRT6	0.812402992	6.90E-30
THYM	Epifactor	CDK5RAP1	ZGPAT	0.814579512	3.67E-30
THYM	Epifactor	CDK5RAP1	ACTR5	0.820324601	6.67E-31
THYM	Epifactor	CDK5RAP1	INO80E	0.825461611	1.38E-31
THYM	IUPHAR	CDK5RAP1	PHKG2	0.802911265	9.84E-29
THYM	IUPHAR	CDK5RAP1	SIRT6	0.812402992	6.90E-30
THYM	Kinase	CDK5RAP1	PHKG2	0.802911265	9.84E-29
THYM	TF	CDK5RAP1	DNTTIP1	0.806865295	3.31E-29
THYM	TF	CDK5RAP1	ZGPAT	0.814579512	3.67E-30
THYM	TSG	CDK5RAP1	BRMS1	0.809792113	1.45E-29
THYM	TSG	CDK5RAP1	NPRL2	0.809860426	1.43E-29
THYM	TSG	CDK5RAP1	SIRT6	0.812402992	6.90E-30
THYM	TSG	CDK5RAP1	GADD45GIP1	0.821707325	4.38E-31
UCS	Cell metabolism gene	CDK5RAP1	TIMM8B	0.801820058	1.32E-28
UCS	Cell metabolism gene	CDK5RAP1	PHKG2	0.802911265	9.84E-29
UCS	Cell metabolism gene	CDK5RAP1	PSME2	0.80326997	8.92E-29
UCS	Cell metabolism gene	CDK5RAP1	TIMM17B	0.804352592	6.63E-29
UCS	Cell metabolism gene	CDK5RAP1	PFDN4	0.804884228	5.73E-29
UCS	Cell metabolism gene	CDK5RAP1	ITPA	0.808171324	2.30E-29
UCS	Cell metabolism gene	CDK5RAP1	PSMD4	0.810984506	1.04E-29
UCS	Cell metabolism gene	CDK5RAP1	POLR2I	0.811068518	1.01E-29
UCS	Cell metabolism gene	CDK5RAP1	SNRPD2	0.813643566	4.82E-30
UCS	Cell metabolism gene	CDK5RAP1	PSMB7	0.814377896	3.89E-30
UCS	Cell metabolism gene	CDK5RAP1	HSD17B10	0.815375466	2.91E-30
UCS	Cell metabolism gene	CDK5RAP1	PSMC1	0.821665686	4.44E-31
UCS	Cell metabolism gene	CDK5RAP1	TIMM50	0.825074492	1.55E-31
UCS	Cell metabolism gene	CDK5RAP1	PSMB3	0.828122596	5.96E-32
UCS	Cell metabolism gene	CDK5RAP1	TOMM40	0.829215746	4.21E-32
UCS	Cell metabolism gene	CDK5RAP1	ACOT8	0.832764079	1.34E-32
UCS	Cell metabolism gene	CDK5RAP1	EBP	0.832831154	1.31E-32
UCS	Epifactor	CDK5RAP1	PRPF31	0.80828289	2.23E-29
UCS	Epifactor	CDK5RAP1	BRMS1	0.809792113	1.45E-29
UCS	Epifactor	CDK5RAP1	ZNHIT1	0.811499611	8.94E-30
UCS	Epifactor	CDK5RAP1	SIRT6	0.812402992	6.90E-30
UCS	Epifactor	CDK5RAP1	ZGPAT	0.814579512	3.67E-30
UCS	Epifactor	CDK5RAP1	ACTR5	0.820324601	6.67E-31
UCS	Epifactor	CDK5RAP1	INO80E	0.825461611	1.38E-31
UCS	IUPHAR	CDK5RAP1	PHKG2	0.802911265	9.84E-29
UCS	IUPHAR	CDK5RAP1	SIRT6	0.812402992	6.90E-30
UCS	Kinase	CDK5RAP1	PHKG2	0.802911265	9.84E-29
UCS	TF	CDK5RAP1	DNTTIP1	0.806865295	3.31E-29
UCS	TF	CDK5RAP1	ZGPAT	0.814579512	3.67E-30
UCS	TSG	CDK5RAP1	BRMS1	0.809792113	1.45E-29
UCS	TSG	CDK5RAP1	NPRL2	0.809860426	1.43E-29
UCS	TSG	CDK5RAP1	SIRT6	0.812402992	6.90E-30
UCS	TSG	CDK5RAP1	GADD45GIP1	0.821707325	4.38E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	CDK5RAP1	PLTP	1.06954476730787	0.00010840546945246
HNSC	CDK5RAP1	CDK5R1	1.37292259433844	0.000172794781747143
KIRP	CDK5RAP1	CDK5R1	-1.20896936898017	0.000234263017773628
STAD	CDK5RAP1	TRMU	-1.01642610446473	0.00361521635204554
KICH	CDK5RAP1	TRMU	2.0137405661954	0.00557881593704224
ESCA	CDK5RAP1	TRMU	-1.21180682199353	0.013671875
UCEC	CDK5RAP1	CDK5	-3.96536107977514	0.015625
UCEC	CDK5RAP1	CDK5R1	-3.36038410547384	0.015625
BLCA	CDK5RAP1	CDK5R1	-3.33459993174137	0.0180816650390625
HNSC	CDK5RAP1	PLTP	2.40070895190329	0.0265030336049676
CHOL	CDK5RAP1	CDK5	-6.01644937924613	0.02734375
CHOL	CDK5RAP1	CDK5R1	-1.40831127169556	0.02734375
KIRC	CDK5RAP1	CDK5	-1.20507317666492	1.04336657477644e-05
KICH	CDK5RAP1	TRIT1	2.97402325130185	1.19209289550781e-07
BRCA	CDK5RAP1	CDK5R1	-1.70460912685192	1.45639384659002e-16
KICH	CDK5RAP1	CDK5R1	-1.87634073678737	1.96695327758789e-06
THCA	CDK5RAP1	TRIT1	-2.80035466979561	2.66386605625348e-05
BLCA	CDK5RAP1	TRIT1	3.5336547877957	3.814697265625e-06
LUSC	CDK5RAP1	TRMU	-2.71608164177158	4.69835911599163e-07
KICH	CDK5RAP1	PLTP	1.26177149129365	5.24520874023437e-06
PRAD	CDK5RAP1	CDK5R1	-1.33213325793624	5.28685894712292e-08
LUAD	CDK5RAP1	CDK5R1	-4.23728003480487	5.58846210385235e-10
KIRC	CDK5RAP1	CDK5R1	-1.31554494023695	5.64417171139558e-12
LUAD	CDK5RAP1	CDK5	-2.51775917389116	5.71853870724502e-08
LUSC	CDK5RAP1	CDK5	-2.86626011122885	8.4644938627013e-08
BRCA	CDK5RAP1	CDK5	-2.65574164985352	9.52250150985207e-30

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CDK5RAP1

CDK5R1, BAG3, EXOSC3, EXOSC5, KCTD17, C9orf41, WWP2, KIAA0930, ZMYND19, NDUFAF5, XRCC6, XRCC5, PDZK1, PLA2G10, ZZEF1, ARMC8, MATR3, HNRNPL, RIPK4, MRM1, TRMT61B, HDAC2, SNRNP70, PLEKHA4, OPTN, E, nsp16, ORF6, IMMP2L, AUH, C12orf65, C1QBP, C21orf33, C6orf203, MCUR1, GFM1, HINT2, ICT1, METTL17, MRPL11, MRPS12, MRRF, MTERF3, MTG2, MTIF2, MTRF1L, PMPCB, SSBP1, TBRG4, TEFM, TRUB2, TSFM, EXD2, LDLR, CLPP, HSCB, AARS2, COX8A, CS, PDHA1, GPSM3, HS1BP3, MAEA, UQCRFS1, GCAT, LDLRAD1, AMACR, HHIPL1, SSC4D, NDUFS7, TUBB, TUBB2A, NDUFS6, YARS2, CA6, FAHD1, ARID3B, SLURP1, FAM174A, NAA38, WDYHV1, VASP, MRPS24, CLEC11A, AK4, FTSJ2, FMOD, SFTPA2, FAM219B, TRIM43, RAB43, HEXIM2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CDK5RAP1	chr20	31967262	C	T	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CDK5RAP1	chr20	31975209	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CDK5RAP1	SKCM	chr20	31967359	31967359	G	A	Missense_Mutation	p.R353C	5
CDK5RAP1	LIHC	chr20	31954764	31954764	T	-	Frame_Shift_Del	p.K495fs	4
CDK5RAP1	UCEC	chr20	31967358	31967358	C	T	Missense_Mutation	p.R339H	4
CDK5RAP1	PAAD	chr20	31979986	31979986	C	T	Missense_Mutation	p.R169Q	3
CDK5RAP1	PAAD	chr20	31973465	31973465	A	G	Silent	p.L289L	3
CDK5RAP1	HNSC	chr20	31973565	31973565	C	T	Missense_Mutation	p.R256Q	3
CDK5RAP1	BRCA	chr20	31961928	31961928	G	A	Missense_Mutation	p.R400W	3
CDK5RAP1	HNSC	chr20	31958354	31958354	C	G	Missense_Mutation		3
CDK5RAP1	ESCA	chr20	31984822	31984822	C	T	Missense_Mutation	p.G17R	3
CDK5RAP1	PAAD	chr20	31984682	31984682	C	T	Silent	p.P63P	3
CDK5RAP1	BRCA	chr20	31967344	31967344	G	A	Silent	p.L344	2
CDK5RAP1	ESCA	chr20	31984822	31984822	C	T	Missense_Mutation		2
CDK5RAP1	HNSC	chr20	31958354	31958354	C	G	Missense_Mutation	p.R462P	2
CDK5RAP1	UCEC	chr20	31975296	31975296	C	A	Missense_Mutation	p.E196D	2
CDK5RAP1	BRCA	chr20	31975264	31975264	G	A	Missense_Mutation	p.A207V	2
CDK5RAP1	STAD	chr20	31975140	31975140	C	T	Silent	p.T248T	2
CDK5RAP1	HNSC	chr20	31980046	31980046	T	C	Missense_Mutation	p.E149G	2
CDK5RAP1	LIHC	chr20	31958330	31958330	A	-	Frame_Shift_Del	p.F470fs	2
CDK5RAP1	UCEC	chr20	31979980	31979980	C	T	Missense_Mutation	p.R171H	2
CDK5RAP1	BRCA	chr20	31984736	31984736	C	A	Missense_Mutation	p.E45D	2
CDK5RAP1	LIHC	chr20	31967440	31967440	C	G	Missense_Mutation		2
CDK5RAP1	PCPG	chr20	31984647	31984647	G	A	Missense_Mutation		2
CDK5RAP1	BLCA	chr20	31962020	31962020	T	G	Splice_Site		2
CDK5RAP1	LIHC	chr20	31975292	31975292	T	-	Frame_Shift_Del	p.M198fs	2
CDK5RAP1	MESO	chr20	31954812	31954812	C	T	Missense_Mutation	p.D422N	2
CDK5RAP1	PCPG	chr20	31984647	31984647	G	A	Missense_Mutation	p.P75L	2
CDK5RAP1	BLCA	chr20	31946862	31946862	G	C	Missense_Mutation	p.S598C	2
CDK5RAP1	STAD	chr20	31961920	31961920	C	-	Splice_Site		2
CDK5RAP1	CESC	chr20	31954734	31954734	G	T	Silent		2
CDK5RAP1	HNSC	chr20	31967498	31967498	C	G	Splice_Site		2
CDK5RAP1	PRAD	chr20	31961946	31961946	G	A	Missense_Mutation	p.R408C	2
CDK5RAP1	KIRC	chr20	31946924	31946924	G	A	Silent	p.T563T	2
CDK5RAP1	STAD	chr20	31979974	31979974	C	T	Missense_Mutation		2
CDK5RAP1	PAAD	chr20	31984682	31984682	C	T	Silent		2
CDK5RAP1	KIRC	chr20	31967381	31967381	A	T	Nonsense_Mutation	p.Y345*	2
CDK5RAP1	LUAD	chr20	31973519	31973519	C	A	Silent	p.R271R	2
CDK5RAP1	STAD	chr20	31982904	31982904	C	T	Missense_Mutation	p.G108D	2
CDK5RAP1	KIRC	chr20	31946924	31946924	G	A	Silent	p.T577T	2
CDK5RAP1	PAAD	chr20	31979986	31979986	C	T	Missense_Mutation		2
CDK5RAP1	SKCM	chr20	31967359	31967359	G	A	Missense_Mutation	p.R249C	2
CDK5RAP1	THCA	chr20	31981850	31981850	G	A	Missense_Mutation	p.T144I	2
CDK5RAP1	UCEC	chr20	31954807	31954807	C	T	Missense_Mutation	p.R467Q	2
CDK5RAP1	UCEC	chr20	31967310	31967310	C	A	Missense_Mutation	p.R355M	2
CDK5RAP1	ESCA	chr20	31984794	31984794	G	A	Missense_Mutation		2
CDK5RAP1	HNSC	chr20	31967483	31967483	C	T	Silent	p.V311V	2
CDK5RAP1	LIHC	chr20	31973536	31973536	T	C	Missense_Mutation		1
CDK5RAP1	LUSC	chr20	31960462	31960462	C	A	Missense_Mutation	p.R430I	1
CDK5RAP1	SKCM	chr20	31975170	31975170	G	A	Silent	p.V238V	1
CDK5RAP1	BLCA	chr20	31948265	31948265	G	T	Silent		1
CDK5RAP1	STAD	chr20	31967484	31967484	A	G	Missense_Mutation	p.V297A	1
CDK5RAP1	BLCA	chr20	31973485	31973485	G	C	Missense_Mutation	p.L283V	1
CDK5RAP1	SKCM	chr20	31982865	31982865	G	A	Missense_Mutation	p.S121F	1
CDK5RAP1	LIHC	chr20	31946923	31946923	A	G	Missense_Mutation		1
CDK5RAP1	LUSC	chr20	31967387	31967387	G	T	Silent	p.T343T	1
CDK5RAP1	SKCM	chr20	31967344	31967344	G	A	Silent	p.L358L	1
CDK5RAP1	BLCA	chr20	31973485	31973485	G	C	Missense_Mutation		1
CDK5RAP1	ESCA	chr20	31967447	31967447	G	T	Missense_Mutation	p.D309E	1
CDK5RAP1	BLCA	chr20	31948220	31948220	C	T	Missense_Mutation	p.M554I	1
CDK5RAP1	SKCM	chr20	31961942	31961942	A	C	Missense_Mutation	p.V409G	1
CDK5RAP1	SKCM	chr20	31979977	31979977	G	A	Missense_Mutation	p.S172F	1
CDK5RAP1	LUSC	chr20	31967306	31967306	G	T	Silent	p.I370I	1
CDK5RAP1	BLCA	chr20	31948220	31948220	C	T	Missense_Mutation		1
CDK5RAP1	ESCA	chr20	31984794	31984794	G	A	Missense_Mutation	p.S26L	1
CDK5RAP1	STAD	chr20	31958354	31958354	C	T	Missense_Mutation	p.R462Q	1
CDK5RAP1	SKCM	chr20	31973529	31973529	G	A	Missense_Mutation	p.P268L	1
CDK5RAP1	SKCM	chr20	31984706	31984706	G	A	Silent	p.F55F	1
CDK5RAP1	LIHC	chr20	31973469	31973469	T	C	Missense_Mutation	p.K288R	1
CDK5RAP1	BLCA	chr20	31946862	31946862	G	C	Missense_Mutation		1
CDK5RAP1	HNSC	chr20	31967483	31967483	C	T	Silent		1
CDK5RAP1	STAD	chr20	31979974	31979974	C	T	Missense_Mutation	p.R173Q	1
CDK5RAP1	HNSC	chr20	31967498	31967498	C	G	Splice_Site	p.G307_splice	1
CDK5RAP1	LIHC	chr20	31954758	31954758	C	-	Frame_Shift_Del	p.R498fs	1
CDK5RAP1	OV	chr20	31448341	31448341	G	T	Missense_Mutation		1
CDK5RAP1	LIHC	chr20	31967440	31967440	C	G	Missense_Mutation	p.E312Q	1
CDK5RAP1	BLCA	chr20	31961946	31961946	G	A	Missense_Mutation		1
CDK5RAP1	STAD	chr20	31954730	31954730	G	T	Silent	p.R507R	1
CDK5RAP1	BLCA	chr20	31958311	31958311	C	T	Missense_Mutation	p.M476I	1
CDK5RAP1	LIHC	chr20	31958339	31958339	T	-	Frame_Shift_Del	p.N467fs	1
CDK5RAP1	SKCM	chr20	31967319	31967319	G	A	Missense_Mutation	p.P366L	1
CDK5RAP1	OV	chr20	31979987	31979987	G	A	Missense_Mutation	p.R169W	1
CDK5RAP1	COAD	chr20	31973533	31973533	C	T	Missense_Mutation	p.V177I	1
CDK5RAP1	LIHC	chr20	31967440	31967440	C	G	Missense_Mutation	p.E326Q	1
CDK5RAP1	BLCA	chr20	31958311	31958311	C	T	Missense_Mutation		1
CDK5RAP1	HNSC	chr20	31980046	31980046	T	C	Missense_Mutation		1
CDK5RAP1	SKCM	chr20	31975337	31975337	A	C	Missense_Mutation	p.C93G	1
CDK5RAP1	STAD	chr20	31967484	31967484	A	G	Missense_Mutation	p.V311A	1
CDK5RAP1	THYM	chr20	31958405	31958405	C	T	Missense_Mutation	p.G431D	1
CDK5RAP1	BLCA	chr20	31954743	31954743	G	A	Silent	p.L502L	1
CDK5RAP1	KIRC	chr20	31958402	31958402	A	T	Missense_Mutation	p.F432Y	1
CDK5RAP1	LIHC	chr20	31973534	31973534	A	-	Frame_Shift_Del	p.I266fs	1
CDK5RAP1	SKCM	chr20	31967317	31967317	C	T	Missense_Mutation	p.E367K	1
CDK5RAP1	STAD	chr20	31961920	31961920	C	-	Splice_Site	.	1
CDK5RAP1	COAD	chr20	31981849	31981849	T	C	Silent	p.T54T	1
CDK5RAP1	BLCA	chr20	31954743	31954743	G	A	Silent		1
CDK5RAP1	HNSC	chr20	31973565	31973565	C	T	Missense_Mutation		1
CDK5RAP1	SKCM	chr20	31967344	31967344	G	A	Silent	p.L254L	1
CDK5RAP1	STAD	chr20	31962015	31962015	G	T	Missense_Mutation	p.L385M	1
CDK5RAP1	UCEC	chr20	31984846	31984846	G	T	Missense_Mutation	p.Q9K	1
CDK5RAP1	BLCA	chr20	31973474	31973474	C	T	Silent	p.V286V	1
CDK5RAP1	SKCM	chr20	31975337	31975337	A	C	Missense_Mutation	p.C183G	1
CDK5RAP1	PAAD	chr20	31973465	31973465	A	G	Silent		1
CDK5RAP1	COAD	chr20	31984727	31984727	C	T	Silent	p.E48E	1
CDK5RAP1	BLCA	chr20	31973474	31973474	C	T	Silent		1
CDK5RAP1	SKCM	chr20	31982865	31982865	G	A	Missense_Mutation	p.S31F	1
CDK5RAP1	STAD	chr20	31980017	31980017	A	G	Silent	p.L159L	1
CDK5RAP1	UCEC	chr20	31980006	31980006	A	G	Silent	p.L162L	1
CDK5RAP1	BLCA	chr20	31948225	31948225	C	G	Missense_Mutation	p.E553Q	1
CDK5RAP1	LUAD	chr20	31967468	31967468	C	G	Missense_Mutation	p.Q316H	1
CDK5RAP1	SKCM	chr20	31967305	31967305	G	A	Missense_Mutation	p.R371C	1
CDK5RAP1	STAD	chr20	31960473	31960476	AACT	-	Frame_Shift_Del	p.412_413del	1
CDK5RAP1	ACC	chr20	31967333	31967333	G	C	Silent	p.V347V	1
CDK5RAP1	COAD	chr20	31967304	31967304	C	T	Missense_Mutation	p.R267H	1
CDK5RAP1	BLCA	chr20	31948225	31948225	C	G	Missense_Mutation		1
CDK5RAP1	HNSC	chr20	31975138	31975138	G	T	Missense_Mutation		1
CDK5RAP1	BLCA	chr20	31961944	31961944	A	T	Silent	p.R408R	1
CDK5RAP1	LGG	chr20	31958332	31958333	-	CC	Frame_Shift_Ins	p.V469fs	1
CDK5RAP1	LUAD	chr20	31984820	31984820	T	A	Silent	p.G17G	1
CDK5RAP1	SKCM	chr20	31975249	31975249	G	A	Missense_Mutation	p.P212L	1
CDK5RAP1	PAAD	chr20	31967401	31967401	G	T	Missense_Mutation		1
CDK5RAP1	STAD	chr20	31954730	31954730	G	T	Silent	p.R493R	1
CDK5RAP1	ACC	chr20	31967333	31967333	G	C	Silent	p.V257V	1
CDK5RAP1	BLCA	chr20	31961944	31961944	A	T	Silent		1
CDK5RAP1	HNSC	chr20	31975138	31975138	G	T	Missense_Mutation	p.S249Y	1
CDK5RAP1	SKCM	chr20	31975249	31975249	G	A	Missense_Mutation	p.P122L	1
CDK5RAP1	BLCA	chr20	31962020	31962020	T	G	Splice_Site	p.V384_splice	1
CDK5RAP1	LIHC	chr20	31967330	31967330	G	A	Silent		1
CDK5RAP1	LUSC	chr20	31984835	31984835	C	A	Missense_Mutation	p.R12S	1
CDK5RAP1	SKCM	chr20	31967440	31967440	C	T	Missense_Mutation	p.E326K	1
CDK5RAP1	STAD	chr20	31962015	31962015	G	T	Missense_Mutation	p.L371M	1
CDK5RAP1	ACC	chr20	31967333	31967333	G	C	Silent	p.V361V	1
CDK5RAP1	BLCA	chr20	31948265	31948265	G	T	Silent	p.G539G	1
CDK5RAP1	SKCM	chr20	31973529	31973529	G	A	Missense_Mutation	p.P178L	1

Copy number variation (CNV) of CDK5RAP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CDK5RAP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100981	LUAD	TCGA-75-6211-01A	CDK5RAP1	chr20	31967267	-	CDH4	chr20	60503248	+
15266	N/A	AX186755	CDK5RAP1	chr20	31963586	+	CTD-3105H18.18	chr19	12556402	+
102971	STAD	TCGA-MX-A666-01A	CDK5RAP1	chr20	31973456	-	EPS15L1	chr19	16466662	-
103056	LUAD	TCGA-55-8206-01A	CDK5RAP1	chr20	31979948	-	GNAS	chr20	57478586	+
103056	LUAD	TCGA-55-8206-01A	CDK5RAP1	chr20	31979949	-	GNAS	chr20	57478582	+
86647	STAD	TCGA-CD-8525-01A	CDK5RAP1	chr20	31989234	-	HNRNPLL	chr2	38813023	-
95728	OV	TCGA-31-1951-01A	CDK5RAP1	chr20	31967267	-	TMEM248	chr7	66406835	+
35692	BRCA	TCGA-BH-A0DI-01A	CDK5RAP1	chr20	31989234	-	ZMIZ2	chr7	44798880	+
91932	N/A	GM682738	KRCC1	chr2	88326724	-	CDK5RAP1	chr20	31959956	+
91932	BLCA	TCGA-BL-A0C8	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
91932	BLCA	TCGA-BL-A0C8-01A	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
91932	BRCA	TCGA-E9-A1NF-01A	NUP50	chr22	45571961	+	CDK5RAP1	chr20	31946929	-
91932	N/A	AA319710	PPP2R2C	chr4	6325065	-	CDK5RAP1	chr20	31954692	-
91932	COAD	TCGA-A6-2677	PTPRA	chr20	2854406	+	CDK5RAP1	chr20	31975339	-
91932	LUAD	TCGA-49-4512-01A	RALY	chr20	32619410	+	CDK5RAP1	chr20	31946929	-
91932	PRAD	TCGA-ZG-A9L9-01A	TFAP2A	chr6	10402725	-	CDK5RAP1	chr20	31958435	-
91938	STAD	TCGA-HU-A4G8	TMEM230	chr20	5093606	-	CDK5RAP1	chr20	31984890	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	CDK5RAP1	0.00487620012617561	0.14
UVM	CDK5RAP1	0.0183310459523701	0.49
LUSC	CDK5RAP1	0.0382806933736325	1
ACC	CDK5RAP1	0.0385725762947162	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	CDK5RAP1	0.0440935534192686	1
THCA	CDK5RAP1	0.00669366074390932	0.21
LGG	CDK5RAP1	0.0334765580125143	1
BRCA	CDK5RAP1	0.0418119483803422	1
PAAD	CDK5RAP1	0.00508413147542024	0.16
UCEC	CDK5RAP1	0.000492172186779164	0.016

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source