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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TRNAU1AP (NCBI Gene ID:54952)

Gene Summary

Gene Summary

Gene Information	Gene Name: TRNAU1AP
	Gene ID: 54952
	Gene Symbol	TRNAU1AP
	Gene ID	54952
	Gene Name	tRNA selenocysteine 1 associated protein 1
	Synonyms	PRO1902\|SECP43\|TRSPAP1
	Cytomap	1p35.3
	Type of Gene	protein-coding
	Description	tRNA selenocysteine 1-associated protein 1tRNA selenocysteine associated protein (SECP43)tRNA selenocysteine-associated protein 1
	Modification date	20200313
	UniProtAcc	Q9NX07

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TRNAU1AP	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'TRNAU1AP[title] AND translation [title] AND human.'

Gene	Title	PMID
TRNAU1AP	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000373830	28887144	28887244	Frame-shift
ENST00000373830	28893805	28893925	In-frame
ENST00000373830	28897687	28897850	Frame-shift
ENST00000373830	28898378	28898412	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000373830	28893805	28893925	1810	437	556	287	137	176

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9NX07	137	176	1	287	Chain	ID=PRO_0000304917;Note=tRNA selenocysteine 1-associated protein 1
Q9NX07	137	176	96	175	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q9NX07	137	176	136	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DHG
Q9NX07	137	176	147	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DHG
Q9NX07	137	176	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DHG
Q9NX07	137	176	162	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DHG

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	TRNAU1AP	-1.56635696696237	0.000137265065605683
CHOL	TRNAU1AP	-1.36228203168816	0.02734375
THCA	TRNAU1AP	-2.34899508686103	1.55290879513537e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LIHC	TRNAU1AP	-0.081095205	0.029863767

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TRNAU1AP (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	Cell metabolism gene	TRNAU1AP	SNRPG	0.826860667	2.38E-44
KICH	Cell metabolism gene	TRNAU1AP	TXNDC12	0.818840134	3.59E-23
KICH	Cell metabolism gene	TRNAU1AP	LSM2	0.822606762	1.54E-23
KICH	IUPHAR	TRNAU1AP	STK19	0.811938161	1.61E-22
KICH	Kinase	TRNAU1AP	STK19	0.811938161	1.61E-22
KICH	TF	TRNAU1AP	CREB3L4	0.817970903	4.35E-23
KICH	TSG	TRNAU1AP	TTC4	0.855372113	3.70E-27
LGG	Cell metabolism gene	TRNAU1AP	AK2	0.809053122	5.76E-124
LGG	Cell metabolism gene	TRNAU1AP	PSMA5	0.809284732	4.32E-124
LGG	TSG	TRNAU1AP	TTC4	0.83622005	7.22E-140
TGCT	Epifactor	TRNAU1AP	INO80E	0.8028673	2.03E-36
THYM	Cell metabolism gene	TRNAU1AP	TOMM22	0.801350663	1.50E-28
THYM	Cell metabolism gene	TRNAU1AP	ACTB	0.808370416	2.17E-29
THYM	Cell metabolism gene	TRNAU1AP	PAFAH1B3	0.810528122	1.18E-29
THYM	Cell metabolism gene	TRNAU1AP	SNRPD3	0.811312358	9.43E-30
THYM	Cell metabolism gene	TRNAU1AP	PSMB1	0.8136885	4.76E-30
THYM	Cell metabolism gene	TRNAU1AP	PGP	0.814186727	4.12E-30
THYM	Cell metabolism gene	TRNAU1AP	SNRPB	0.815800017	2.57E-30
THYM	Cell metabolism gene	TRNAU1AP	PHKG2	0.816355069	2.18E-30
THYM	Cell metabolism gene	TRNAU1AP	POLD2	0.816508993	2.08E-30
THYM	Cell metabolism gene	TRNAU1AP	PSMD9	0.816911898	1.85E-30
THYM	Cell metabolism gene	TRNAU1AP	NT5M	0.817456067	1.57E-30
THYM	Cell metabolism gene	TRNAU1AP	POLR2J	0.818313906	1.22E-30
THYM	Cell metabolism gene	TRNAU1AP	SLC27A5	0.818381879	1.20E-30
THYM	Cell metabolism gene	TRNAU1AP	INPP5K	0.819469304	8.63E-31
THYM	Cell metabolism gene	TRNAU1AP	PSMA6	0.821237681	5.06E-31
THYM	Cell metabolism gene	TRNAU1AP	POLR3K	0.821491725	4.68E-31
THYM	Cell metabolism gene	TRNAU1AP	TIMM22	0.822478858	3.46E-31
THYM	Cell metabolism gene	TRNAU1AP	MTMR14	0.827164151	8.07E-32
THYM	Cell metabolism gene	TRNAU1AP	DGUOK	0.828049916	6.10E-32
THYM	Cell metabolism gene	TRNAU1AP	TIMM13	0.830430482	2.85E-32
THYM	Cell metabolism gene	TRNAU1AP	LSM3	0.833166903	1.17E-32
THYM	Cell metabolism gene	TRNAU1AP	SLC25A11	0.833598426	1.02E-32
THYM	Cell metabolism gene	TRNAU1AP	TIMM8B	0.833870238	9.28E-33
THYM	Cell metabolism gene	TRNAU1AP	APRT	0.835679414	5.10E-33
THYM	Cell metabolism gene	TRNAU1AP	SNRPD1	0.837059734	3.21E-33
THYM	Cell metabolism gene	TRNAU1AP	PSMB10	0.837130522	3.13E-33
THYM	Cell metabolism gene	TRNAU1AP	SNRPF	0.838902222	1.72E-33
THYM	Cell metabolism gene	TRNAU1AP	PSMB3	0.839015194	1.65E-33
THYM	Cell metabolism gene	TRNAU1AP	POLA2	0.840526503	9.85E-34
THYM	Cell metabolism gene	TRNAU1AP	ACOT8	0.841397506	7.29E-34
THYM	Cell metabolism gene	TRNAU1AP	DTYMK	0.841698068	6.56E-34
THYM	Cell metabolism gene	TRNAU1AP	FAU	0.841710808	6.53E-34
THYM	Cell metabolism gene	TRNAU1AP	GUK1	0.843831754	3.11E-34
THYM	Cell metabolism gene	TRNAU1AP	MED18	0.845057034	2.01E-34
THYM	Cell metabolism gene	TRNAU1AP	ZNRD1	0.846520381	1.19E-34
THYM	Cell metabolism gene	TRNAU1AP	PSMB6	0.847292182	9.03E-35
THYM	Cell metabolism gene	TRNAU1AP	LSM5	0.848008351	6.97E-35
THYM	Cell metabolism gene	TRNAU1AP	PSMA5	0.848596991	5.62E-35
THYM	Cell metabolism gene	TRNAU1AP	APOA1	0.852669352	1.24E-35
THYM	Cell metabolism gene	TRNAU1AP	UROD	0.854351623	6.58E-36
THYM	Cell metabolism gene	TRNAU1AP	PSMA4	0.855115426	4.92E-36
THYM	Cell metabolism gene	TRNAU1AP	AAAS	0.858120686	1.54E-36
THYM	Cell metabolism gene	TRNAU1AP	GALK1	0.858778267	1.19E-36
THYM	Cell metabolism gene	TRNAU1AP	SNRPD2	0.859386106	9.33E-37
THYM	Cell metabolism gene	TRNAU1AP	LSM4	0.86227196	2.94E-37
THYM	Cell metabolism gene	TRNAU1AP	LSM2	0.868634207	2.10E-38
THYM	Cell metabolism gene	TRNAU1AP	SEC61B	0.869441579	1.49E-38
THYM	Cell metabolism gene	TRNAU1AP	FPGS	0.869762659	1.29E-38
THYM	Cell metabolism gene	TRNAU1AP	PSMB7	0.87223317	4.43E-39
THYM	Cell metabolism gene	TRNAU1AP	PSMD13	0.899299442	6.37E-45
THYM	Cell metabolism gene	TRNAU1AP	PSMC3	0.905431183	1.77E-46
THYM	CGC	TRNAU1AP	U2AF1	0.812821155	6.11E-30
THYM	CGC	TRNAU1AP	BAX	0.827651681	6.92E-32
THYM	CGC	TRNAU1AP	RBM10	0.834586174	7.33E-33
THYM	CGC	TRNAU1AP	SDHAF2	0.862110049	3.14E-37
THYM	CGC	TRNAU1AP	TFPT	0.881943935	5.21E-41
THYM	Epifactor	TRNAU1AP	SUV420H2	0.801036318	1.64E-28
THYM	Epifactor	TRNAU1AP	HIST1H2AJ	0.803338007	8.76E-29
THYM	Epifactor	TRNAU1AP	MBD3	0.803782752	7.76E-29
THYM	Epifactor	TRNAU1AP	SIRT6	0.805610355	4.69E-29
THYM	Epifactor	TRNAU1AP	ACTB	0.808370416	2.17E-29
THYM	Epifactor	TRNAU1AP	SUV39H1	0.812840755	6.08E-30
THYM	Epifactor	TRNAU1AP	ANP32B	0.816362663	2.18E-30
THYM	Epifactor	TRNAU1AP	INO80E	0.824860575	1.66E-31
THYM	Epifactor	TRNAU1AP	CDK9	0.825811053	1.23E-31
THYM	Epifactor	TRNAU1AP	PRPF31	0.827963681	6.27E-32
THYM	Epifactor	TRNAU1AP	DMAP1	0.831474725	2.03E-32
THYM	Epifactor	TRNAU1AP	CCDC101	0.831506693	2.01E-32
THYM	Epifactor	TRNAU1AP	ZNHIT1	0.834248882	8.19E-33
THYM	Epifactor	TRNAU1AP	HMGN2	0.83524349	5.89E-33
THYM	Epifactor	TRNAU1AP	H2AFX	0.83661547	3.73E-33
THYM	Epifactor	TRNAU1AP	PPM1G	0.838090012	2.27E-33
THYM	Epifactor	TRNAU1AP	MAZ	0.839317888	1.49E-33
THYM	Epifactor	TRNAU1AP	HIST2H2AC	0.840391082	1.03E-33
THYM	Epifactor	TRNAU1AP	RBX1	0.845375334	1.80E-34
THYM	Epifactor	TRNAU1AP	HIRIP3	0.848469152	5.89E-35
THYM	Epifactor	TRNAU1AP	BRMS1	0.84865144	5.51E-35
THYM	Epifactor	TRNAU1AP	CXXC1	0.851017327	2.31E-35
THYM	Epifactor	TRNAU1AP	SS18L2	0.857977431	1.62E-36
THYM	Epifactor	TRNAU1AP	PRMT7	0.860019878	7.26E-37
THYM	Epifactor	TRNAU1AP	MCRS1	0.862939762	2.24E-37
THYM	Epifactor	TRNAU1AP	C17orf49	0.866082822	6.15E-38
THYM	Epifactor	TRNAU1AP	TAF10	0.867889597	2.88E-38
THYM	Epifactor	TRNAU1AP	RUVBL2	0.871862266	5.21E-39
THYM	Epifactor	TRNAU1AP	PPP4C	0.87733164	4.50E-40
THYM	Epifactor	TRNAU1AP	TFPT	0.881943935	5.21E-41
THYM	Epifactor	TRNAU1AP	TRIM28	0.881978747	5.12E-41
THYM	IUPHAR	TRNAU1AP	CTRL	0.803429146	8.54E-29
THYM	IUPHAR	TRNAU1AP	SIRT6	0.805610355	4.69E-29
THYM	IUPHAR	TRNAU1AP	SPNS3	0.809376085	1.64E-29
THYM	IUPHAR	TRNAU1AP	SUV39H1	0.812840755	6.08E-30
THYM	IUPHAR	TRNAU1AP	PSMB1	0.8136885	4.76E-30
THYM	IUPHAR	TRNAU1AP	S1PR4	0.81468125	3.56E-30
THYM	IUPHAR	TRNAU1AP	PHKG2	0.816355069	2.18E-30
THYM	IUPHAR	TRNAU1AP	NT5M	0.817456067	1.57E-30
THYM	IUPHAR	TRNAU1AP	SLC27A5	0.818381879	1.20E-30
THYM	IUPHAR	TRNAU1AP	INPP5K	0.819469304	8.63E-31
THYM	IUPHAR	TRNAU1AP	CDK9	0.825811053	1.23E-31
THYM	IUPHAR	TRNAU1AP	SLC25A11	0.833598426	1.02E-32
THYM	IUPHAR	TRNAU1AP	PSMB6	0.847292182	9.03E-35
THYM	IUPHAR	TRNAU1AP	PPIA	0.848998666	4.86E-35
THYM	IUPHAR	TRNAU1AP	CSNK2B	0.851999843	1.60E-35
THYM	IUPHAR	TRNAU1AP	PRMT7	0.860019878	7.26E-37
THYM	IUPHAR	TRNAU1AP	TWF2	0.865763397	7.02E-38
THYM	IUPHAR	TRNAU1AP	TRIM28	0.881978747	5.12E-41
THYM	Kinase	TRNAU1AP	PHKG2	0.816355069	2.18E-30
THYM	Kinase	TRNAU1AP	CDK9	0.825811053	1.23E-31
THYM	Kinase	TRNAU1AP	TRIM28	0.881978747	5.12E-41
THYM	TF	TRNAU1AP	MBD3	0.803782752	7.76E-29
THYM	TF	TRNAU1AP	TIGD3	0.803992725	7.32E-29
THYM	TF	TRNAU1AP	RBCK1	0.808534373	2.07E-29
THYM	TF	TRNAU1AP	THAP3	0.809858141	1.43E-29
THYM	TF	TRNAU1AP	NAIF1	0.815878999	2.51E-30
THYM	TF	TRNAU1AP	ZNF668	0.816208143	2.28E-30
THYM	TF	TRNAU1AP	ZNF688	0.816941454	1.83E-30
THYM	TF	TRNAU1AP	ZNF691	0.817112889	1.74E-30
THYM	TF	TRNAU1AP	ZBTB17	0.822450587	3.49E-31
THYM	TF	TRNAU1AP	MXD3	0.838562313	1.93E-33
THYM	TF	TRNAU1AP	ZNF428	0.839206167	1.55E-33
THYM	TF	TRNAU1AP	MAZ	0.839317888	1.49E-33
THYM	TF	TRNAU1AP	DRAP1	0.844312332	2.62E-34
THYM	TF	TRNAU1AP	CXXC1	0.851017327	2.31E-35
THYM	TF	TRNAU1AP	ZNF653	0.858693536	1.23E-36
THYM	TF	TRNAU1AP	GTF3A	0.865446722	8.01E-38
THYM	TF	TRNAU1AP	PIN1	0.870596442	9.04E-39
THYM	TF	TRNAU1AP	ZNF444	0.884046033	1.89E-41
THYM	TF	TRNAU1AP	THYN1	0.922370228	2.13E-51
THYM	TSG	TRNAU1AP	SIRT6	0.805610355	4.69E-29
THYM	TSG	TRNAU1AP	NPRL2	0.811705062	8.43E-30
THYM	TSG	TRNAU1AP	FBXO25	0.813641605	4.82E-30
THYM	TSG	TRNAU1AP	ZNF668	0.816208143	2.28E-30
THYM	TSG	TRNAU1AP	PARK7	0.821294565	4.97E-31
THYM	TSG	TRNAU1AP	GLTSCR2	0.824913914	1.63E-31
THYM	TSG	TRNAU1AP	PLEKHO1	0.82729121	7.75E-32
THYM	TSG	TRNAU1AP	BAX	0.827651681	6.92E-32
THYM	TSG	TRNAU1AP	TSSC4	0.831672372	1.91E-32
THYM	TSG	TRNAU1AP	H2AFX	0.83661547	3.73E-33
THYM	TSG	TRNAU1AP	GNB2L1	0.844862606	2.16E-34
THYM	TSG	TRNAU1AP	AIF1	0.847166814	9.45E-35
THYM	TSG	TRNAU1AP	BRMS1	0.84865144	5.51E-35
THYM	TSG	TRNAU1AP	PIN1	0.870596442	9.04E-39
THYM	TSG	TRNAU1AP	HTRA2	0.87692886	5.42E-40
THYM	TSG	TRNAU1AP	AIP	0.895974391	4.04E-44
THYM	TSG	TRNAU1AP	PFN1	0.910820649	6.17E-48
UCS	Cell metabolism gene	TRNAU1AP	TOMM22	0.801350663	1.50E-28
UCS	Cell metabolism gene	TRNAU1AP	ACTB	0.808370416	2.17E-29
UCS	Cell metabolism gene	TRNAU1AP	PAFAH1B3	0.810528122	1.18E-29
UCS	Cell metabolism gene	TRNAU1AP	SNRPD3	0.811312358	9.43E-30
UCS	Cell metabolism gene	TRNAU1AP	PSMB1	0.8136885	4.76E-30
UCS	Cell metabolism gene	TRNAU1AP	PGP	0.814186727	4.12E-30
UCS	Cell metabolism gene	TRNAU1AP	SNRPB	0.815800017	2.57E-30
UCS	Cell metabolism gene	TRNAU1AP	PHKG2	0.816355069	2.18E-30
UCS	Cell metabolism gene	TRNAU1AP	POLD2	0.816508993	2.08E-30
UCS	Cell metabolism gene	TRNAU1AP	PSMD9	0.816911898	1.85E-30
UCS	Cell metabolism gene	TRNAU1AP	NT5M	0.817456067	1.57E-30
UCS	Cell metabolism gene	TRNAU1AP	POLR2J	0.818313906	1.22E-30
UCS	Cell metabolism gene	TRNAU1AP	SLC27A5	0.818381879	1.20E-30
UCS	Cell metabolism gene	TRNAU1AP	INPP5K	0.819469304	8.63E-31
UCS	Cell metabolism gene	TRNAU1AP	PSMA6	0.821237681	5.06E-31
UCS	Cell metabolism gene	TRNAU1AP	POLR3K	0.821491725	4.68E-31
UCS	Cell metabolism gene	TRNAU1AP	TIMM22	0.822478858	3.46E-31
UCS	Cell metabolism gene	TRNAU1AP	MTMR14	0.827164151	8.07E-32
UCS	Cell metabolism gene	TRNAU1AP	DGUOK	0.828049916	6.10E-32
UCS	Cell metabolism gene	TRNAU1AP	TIMM13	0.830430482	2.85E-32
UCS	Cell metabolism gene	TRNAU1AP	LSM3	0.833166903	1.17E-32
UCS	Cell metabolism gene	TRNAU1AP	SLC25A11	0.833598426	1.02E-32
UCS	Cell metabolism gene	TRNAU1AP	TIMM8B	0.833870238	9.28E-33
UCS	Cell metabolism gene	TRNAU1AP	APRT	0.835679414	5.10E-33
UCS	Cell metabolism gene	TRNAU1AP	SNRPD1	0.837059734	3.21E-33
UCS	Cell metabolism gene	TRNAU1AP	PSMB10	0.837130522	3.13E-33
UCS	Cell metabolism gene	TRNAU1AP	SNRPF	0.838902222	1.72E-33
UCS	Cell metabolism gene	TRNAU1AP	PSMB3	0.839015194	1.65E-33
UCS	Cell metabolism gene	TRNAU1AP	POLA2	0.840526503	9.85E-34
UCS	Cell metabolism gene	TRNAU1AP	ACOT8	0.841397506	7.29E-34
UCS	Cell metabolism gene	TRNAU1AP	DTYMK	0.841698068	6.56E-34
UCS	Cell metabolism gene	TRNAU1AP	FAU	0.841710808	6.53E-34
UCS	Cell metabolism gene	TRNAU1AP	GUK1	0.843831754	3.11E-34
UCS	Cell metabolism gene	TRNAU1AP	MED18	0.845057034	2.01E-34
UCS	Cell metabolism gene	TRNAU1AP	ZNRD1	0.846520381	1.19E-34
UCS	Cell metabolism gene	TRNAU1AP	PSMB6	0.847292182	9.03E-35
UCS	Cell metabolism gene	TRNAU1AP	LSM5	0.848008351	6.97E-35
UCS	Cell metabolism gene	TRNAU1AP	PSMA5	0.848596991	5.62E-35
UCS	Cell metabolism gene	TRNAU1AP	APOA1	0.852669352	1.24E-35
UCS	Cell metabolism gene	TRNAU1AP	UROD	0.854351623	6.58E-36
UCS	Cell metabolism gene	TRNAU1AP	PSMA4	0.855115426	4.92E-36
UCS	Cell metabolism gene	TRNAU1AP	AAAS	0.858120686	1.54E-36
UCS	Cell metabolism gene	TRNAU1AP	GALK1	0.858778267	1.19E-36
UCS	Cell metabolism gene	TRNAU1AP	SNRPD2	0.859386106	9.33E-37
UCS	Cell metabolism gene	TRNAU1AP	LSM4	0.86227196	2.94E-37
UCS	Cell metabolism gene	TRNAU1AP	LSM2	0.868634207	2.10E-38
UCS	Cell metabolism gene	TRNAU1AP	SEC61B	0.869441579	1.49E-38
UCS	Cell metabolism gene	TRNAU1AP	FPGS	0.869762659	1.29E-38
UCS	Cell metabolism gene	TRNAU1AP	PSMB7	0.87223317	4.43E-39
UCS	Cell metabolism gene	TRNAU1AP	PSMD13	0.899299442	6.37E-45
UCS	Cell metabolism gene	TRNAU1AP	PSMC3	0.905431183	1.77E-46
UCS	CGC	TRNAU1AP	U2AF1	0.812821155	6.11E-30
UCS	CGC	TRNAU1AP	BAX	0.827651681	6.92E-32
UCS	CGC	TRNAU1AP	RBM10	0.834586174	7.33E-33
UCS	CGC	TRNAU1AP	SDHAF2	0.862110049	3.14E-37
UCS	CGC	TRNAU1AP	TFPT	0.881943935	5.21E-41
UCS	Epifactor	TRNAU1AP	SUV420H2	0.801036318	1.64E-28
UCS	Epifactor	TRNAU1AP	HIST1H2AJ	0.803338007	8.76E-29
UCS	Epifactor	TRNAU1AP	MBD3	0.803782752	7.76E-29
UCS	Epifactor	TRNAU1AP	SIRT6	0.805610355	4.69E-29
UCS	Epifactor	TRNAU1AP	ACTB	0.808370416	2.17E-29
UCS	Epifactor	TRNAU1AP	SUV39H1	0.812840755	6.08E-30
UCS	Epifactor	TRNAU1AP	ANP32B	0.816362663	2.18E-30
UCS	Epifactor	TRNAU1AP	INO80E	0.824860575	1.66E-31
UCS	Epifactor	TRNAU1AP	CDK9	0.825811053	1.23E-31
UCS	Epifactor	TRNAU1AP	PRPF31	0.827963681	6.27E-32
UCS	Epifactor	TRNAU1AP	DMAP1	0.831474725	2.03E-32
UCS	Epifactor	TRNAU1AP	CCDC101	0.831506693	2.01E-32
UCS	Epifactor	TRNAU1AP	ZNHIT1	0.834248882	8.19E-33
UCS	Epifactor	TRNAU1AP	HMGN2	0.83524349	5.89E-33
UCS	Epifactor	TRNAU1AP	H2AFX	0.83661547	3.73E-33
UCS	Epifactor	TRNAU1AP	PPM1G	0.838090012	2.27E-33
UCS	Epifactor	TRNAU1AP	MAZ	0.839317888	1.49E-33
UCS	Epifactor	TRNAU1AP	HIST2H2AC	0.840391082	1.03E-33
UCS	Epifactor	TRNAU1AP	RBX1	0.845375334	1.80E-34
UCS	Epifactor	TRNAU1AP	HIRIP3	0.848469152	5.89E-35
UCS	Epifactor	TRNAU1AP	BRMS1	0.84865144	5.51E-35
UCS	Epifactor	TRNAU1AP	CXXC1	0.851017327	2.31E-35
UCS	Epifactor	TRNAU1AP	SS18L2	0.857977431	1.62E-36
UCS	Epifactor	TRNAU1AP	PRMT7	0.860019878	7.26E-37
UCS	Epifactor	TRNAU1AP	MCRS1	0.862939762	2.24E-37
UCS	Epifactor	TRNAU1AP	C17orf49	0.866082822	6.15E-38
UCS	Epifactor	TRNAU1AP	TAF10	0.867889597	2.88E-38
UCS	Epifactor	TRNAU1AP	RUVBL2	0.871862266	5.21E-39
UCS	Epifactor	TRNAU1AP	PPP4C	0.87733164	4.50E-40
UCS	Epifactor	TRNAU1AP	TFPT	0.881943935	5.21E-41
UCS	Epifactor	TRNAU1AP	TRIM28	0.881978747	5.12E-41
UCS	IUPHAR	TRNAU1AP	CTRL	0.803429146	8.54E-29
UCS	IUPHAR	TRNAU1AP	SIRT6	0.805610355	4.69E-29
UCS	IUPHAR	TRNAU1AP	SPNS3	0.809376085	1.64E-29
UCS	IUPHAR	TRNAU1AP	SUV39H1	0.812840755	6.08E-30
UCS	IUPHAR	TRNAU1AP	PSMB1	0.8136885	4.76E-30
UCS	IUPHAR	TRNAU1AP	S1PR4	0.81468125	3.56E-30
UCS	IUPHAR	TRNAU1AP	PHKG2	0.816355069	2.18E-30
UCS	IUPHAR	TRNAU1AP	NT5M	0.817456067	1.57E-30
UCS	IUPHAR	TRNAU1AP	SLC27A5	0.818381879	1.20E-30
UCS	IUPHAR	TRNAU1AP	INPP5K	0.819469304	8.63E-31
UCS	IUPHAR	TRNAU1AP	CDK9	0.825811053	1.23E-31
UCS	IUPHAR	TRNAU1AP	SLC25A11	0.833598426	1.02E-32
UCS	IUPHAR	TRNAU1AP	PSMB6	0.847292182	9.03E-35
UCS	IUPHAR	TRNAU1AP	PPIA	0.848998666	4.86E-35
UCS	IUPHAR	TRNAU1AP	CSNK2B	0.851999843	1.60E-35
UCS	IUPHAR	TRNAU1AP	PRMT7	0.860019878	7.26E-37
UCS	IUPHAR	TRNAU1AP	TWF2	0.865763397	7.02E-38
UCS	IUPHAR	TRNAU1AP	TRIM28	0.881978747	5.12E-41
UCS	Kinase	TRNAU1AP	PHKG2	0.816355069	2.18E-30
UCS	Kinase	TRNAU1AP	CDK9	0.825811053	1.23E-31
UCS	Kinase	TRNAU1AP	TRIM28	0.881978747	5.12E-41
UCS	TF	TRNAU1AP	MBD3	0.803782752	7.76E-29
UCS	TF	TRNAU1AP	TIGD3	0.803992725	7.32E-29
UCS	TF	TRNAU1AP	RBCK1	0.808534373	2.07E-29
UCS	TF	TRNAU1AP	THAP3	0.809858141	1.43E-29
UCS	TF	TRNAU1AP	NAIF1	0.815878999	2.51E-30
UCS	TF	TRNAU1AP	ZNF668	0.816208143	2.28E-30
UCS	TF	TRNAU1AP	ZNF688	0.816941454	1.83E-30
UCS	TF	TRNAU1AP	ZNF691	0.817112889	1.74E-30
UCS	TF	TRNAU1AP	ZBTB17	0.822450587	3.49E-31
UCS	TF	TRNAU1AP	MXD3	0.838562313	1.93E-33
UCS	TF	TRNAU1AP	ZNF428	0.839206167	1.55E-33
UCS	TF	TRNAU1AP	MAZ	0.839317888	1.49E-33
UCS	TF	TRNAU1AP	DRAP1	0.844312332	2.62E-34
UCS	TF	TRNAU1AP	CXXC1	0.851017327	2.31E-35
UCS	TF	TRNAU1AP	ZNF653	0.858693536	1.23E-36
UCS	TF	TRNAU1AP	GTF3A	0.865446722	8.01E-38
UCS	TF	TRNAU1AP	PIN1	0.870596442	9.04E-39
UCS	TF	TRNAU1AP	ZNF444	0.884046033	1.89E-41
UCS	TF	TRNAU1AP	THYN1	0.922370228	2.13E-51
UCS	TSG	TRNAU1AP	SIRT6	0.805610355	4.69E-29
UCS	TSG	TRNAU1AP	NPRL2	0.811705062	8.43E-30
UCS	TSG	TRNAU1AP	FBXO25	0.813641605	4.82E-30
UCS	TSG	TRNAU1AP	ZNF668	0.816208143	2.28E-30
UCS	TSG	TRNAU1AP	PARK7	0.821294565	4.97E-31
UCS	TSG	TRNAU1AP	GLTSCR2	0.824913914	1.63E-31
UCS	TSG	TRNAU1AP	PLEKHO1	0.82729121	7.75E-32
UCS	TSG	TRNAU1AP	BAX	0.827651681	6.92E-32
UCS	TSG	TRNAU1AP	TSSC4	0.831672372	1.91E-32
UCS	TSG	TRNAU1AP	H2AFX	0.83661547	3.73E-33
UCS	TSG	TRNAU1AP	GNB2L1	0.844862606	2.16E-34
UCS	TSG	TRNAU1AP	AIF1	0.847166814	9.45E-35
UCS	TSG	TRNAU1AP	BRMS1	0.84865144	5.51E-35
UCS	TSG	TRNAU1AP	PIN1	0.870596442	9.04E-39
UCS	TSG	TRNAU1AP	HTRA2	0.87692886	5.42E-40
UCS	TSG	TRNAU1AP	AIP	0.895974391	4.04E-44
UCS	TSG	TRNAU1AP	PFN1	0.910820649	6.17E-48
UVM	TSG	TRNAU1AP	PARK7	0.803996068	2.74E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	TRNAU1AP	SNRPC	1.31914488567847	0.000120222568511963
LIHC	TRNAU1AP	SNRNP70	-1.24726314691249	0.000131999218450268
COAD	TRNAU1AP	SF3B1	-1.80613847758886	0.000190287828445435
HNSC	TRNAU1AP	SNRNP70	-1.39678280201819	0.000333792391984389
PRAD	TRNAU1AP	SNRPA1	-1.07177192796564	0.000389431583638804
COAD	TRNAU1AP	PRPF39	-3.45961025960099	0.000524610280990601
BRCA	TRNAU1AP	SEPSECS	-1.49569251700223	0.000941794422102645
COAD	TRNAU1AP	PSTK	-2.83493023793761	0.00197160243988037
LUSC	TRNAU1AP	PSTK	-1.10450833392405	0.00201130880831994
PRAD	TRNAU1AP	PSTK	1.42484344304779	0.00312472017787764
CHOL	TRNAU1AP	SEPSECS	-1.79794121924099	0.00390625
ESCA	TRNAU1AP	SNRPA1	-1.16441200959288	0.0068359375
PRAD	TRNAU1AP	SNRNP70	-1.92025110361916	0.0130781232419534
ESCA	TRNAU1AP	SNRPD3	-1.34158239045332	0.013671875
BLCA	TRNAU1AP	SF3B1	-1.83735297760829	0.0206589639990262
COAD	TRNAU1AP	SEPSECS	-1.79606545257874	0.023610919713974
LIHC	TRNAU1AP	SECISBP2	-1.75320478083999	0.0244988885611231
READ	TRNAU1AP	EEFSEC	-2.14513057008022	0.03125
READ	TRNAU1AP	SNRNP70	-1.94959373395684	0.03125
COAD	TRNAU1AP	EEFSEC	-9.71610086929807	1.59740447998047e-05
LUSC	TRNAU1AP	SNRNP70	-1.66676302684772	1.65402843598856e-05
STAD	TRNAU1AP	SNRPA1	-1.31996994244749	1.73319131135941e-06
KIRP	TRNAU1AP	SNRPD3	1.11820860964659	2.66358256340027e-06
HNSC	TRNAU1AP	SNRPA1	-1.74788780464001	5.60817215955468e-06
COAD	TRNAU1AP	SNRNP70	-4.05487077987472	5.66244125366212e-07
PRAD	TRNAU1AP	SECISBP2	1.87774240131642	5.80245434965193e-05
KIRC	TRNAU1AP	PSTK	2.45946657502431	7.59244533881681e-10
BRCA	TRNAU1AP	SNRPC	-2.40402221553371	9.39298818048331e-22
STAD	TRNAU1AP	SNRNP70	-1.29682459133379	9.4762071967125e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TRNAU1AP

CAND1, LMNB2, PRPF39, ZG16B, BRCA1, APOOL, CENPW, CTNNBL1, FDPS, LUC7L3, PELO, SKA3, KDM6B, TP63, ITFG1, DDX58, SLC25A15, HELZ, ZBTB20, EXPH5, MTO1, SLC25A4, TIMMDC1, SLC25A16, PKP2, ATXN2, BCAS2, QKI, GTSE1, USP10, DMRTB1, RBM42, SECISBP2, PRRC2B, Ssbp1, 2700060E02Rik, Nudt21, Htatsf1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TRNAU1AP	BRCA	chr1	28880170	28880170	G	T	Nonsense_Mutation	p.E16*	4
TRNAU1AP	BRCA	chr1	28904895	28904896	-	ACTT	RNA	NULL	4
TRNAU1AP	UCS	chr1	28897731	28897731	A	G	Missense_Mutation	p.S192G	3
TRNAU1AP	ESCA	chr1	28897783	28897783	A	G	Missense_Mutation	p.Y209C	3
TRNAU1AP	PAAD	chr1	28891240	28891240	G	T	Missense_Mutation	p.D102Y	3
TRNAU1AP	BRCA	chr1	28904118	28904118	A	T	Silent	p.T278	3
TRNAU1AP	UCEC	chr1	28887750	28887750	G	C	RNA	NULL	2
TRNAU1AP	CESC	chr1	28897738	28897738	A	C	Missense_Mutation		2
TRNAU1AP	LUAD	chr1	28880162	28880162	A	G	Missense_Mutation	p.Y13C	2
TRNAU1AP	UCEC	chr1	28897727	28897727	T	G	Missense_Mutation	p.S190R	2
TRNAU1AP	SARC	chr1	28887176	28887176	G	T	Missense_Mutation		2
TRNAU1AP	CESC	chr1	28904068	28904068	G	A	Missense_Mutation		2
TRNAU1AP	UCEC	chr1	28897780	28897780	G	A	Missense_Mutation	p.G208D	2
TRNAU1AP	SARC	chr1	28904058	28904058	G	T	Missense_Mutation		2
TRNAU1AP	SARC	chr1	28904058	28904058	G	T	Missense_Mutation	p.M258I	2
TRNAU1AP	PAAD	chr1	28891240	28891240	G	T	Missense_Mutation		2
TRNAU1AP	BLCA	chr1	28898397	28898397	G	C	Missense_Mutation	p.D238H	2
TRNAU1AP	SKCM	chr1	28904082	28904082	C	T	Silent	p.D266D	2
TRNAU1AP	BRCA	chr1	28904191	28904192	GA	-	RNA	NULL	2
TRNAU1AP	ESCA	chr1	28897783	28897783	A	G	Missense_Mutation		2
TRNAU1AP	UCEC	chr1	28887186	28887186	C	T	Missense_Mutation	p.A56V	2
TRNAU1AP	LIHC	chr1	28880202	28880202	G	-	Frame_Shift_Del	p.M26fs	1
TRNAU1AP	SARC	chr1	28879629	28879629	G	T	Missense_Mutation		1
TRNAU1AP	THYM	chr1	28879627	28879627	C	T	Missense_Mutation		1
TRNAU1AP	THYM	chr1	28893924	28893924	G	T	Missense_Mutation		1
TRNAU1AP	OV	chr1	28770319	28770319	G	C	Missense_Mutation		1
TRNAU1AP	SARC	chr1	28897732	28897732	G	T	Missense_Mutation		1
TRNAU1AP	CESC	chr1	28897738	28897738	A	C	Missense_Mutation	p.N194T	1
TRNAU1AP	THYM	chr1	28893908	28893908	C	T	Silent		1
TRNAU1AP	OV	chr1	28777579	28777579	T	C	RNA	NULL	1
TRNAU1AP	UCS	chr1	28897731	28897731	A	G	Missense_Mutation		1
TRNAU1AP	BLCA	chr1	28898397	28898397	G	C	Missense_Mutation		1
TRNAU1AP	CESC	chr1	28904068	28904068	G	A	Missense_Mutation	p.E262K	1
TRNAU1AP	THYM	chr1	28879627	28879627	C	T	Missense_Mutation	p.A2V	1
TRNAU1AP	OV	chr1	28763886	28763886	C	T	Silent	p.P121	1
TRNAU1AP	BLCA	chr1	28887162	28887162	G	A	Missense_Mutation		1
TRNAU1AP	COAD	chr1	28891260	28891260	T	C	Silent	p.D108D	1
TRNAU1AP	THYM	chr1	28893924	28893924	G	T	Missense_Mutation	p.A177S	1
TRNAU1AP	THYM	chr1	28887162	28887162	G	T	Missense_Mutation	p.C48F	1
TRNAU1AP	PAAD	chr1	28880217	28880217	G	T	Missense_Mutation		1
TRNAU1AP	BLCA	chr1	28887162	28887162	G	A	Missense_Mutation	p.C48Y	1
TRNAU1AP	SKCM	chr1	28891336	28891336	G	A	Missense_Mutation	p.G134S	1
TRNAU1AP	ESCA	chr1	28904175	28904177	ATG	-	RNA	NULL	1
TRNAU1AP	THYM	chr1	28893908	28893908	C	T	Silent	p.S171S	1
TRNAU1AP	SKCM	chr1	28880232	28880232	C	T	Silent	p.I36I	1
TRNAU1AP	UCEC	chr1	28904041	28904041	G	A	Missense_Mutation	p.A253T	1
TRNAU1AP	PRAD	chr1	28891266	28891266	C	T	Silent	p.G110G	1
TRNAU1AP	SKCM	chr1	28880233	28880233	C	T	Nonsense_Mutation	p.R37*	1
TRNAU1AP	UCEC	chr1	28891254	28891254	C	T	Silent	p.D106D	1
TRNAU1AP	LIHC	chr1	28904033	28904033	T	C	Missense_Mutation		1
TRNAU1AP	READ	chr1	28880172	28880172	G	T	Missense_Mutation	p.E16D	1
TRNAU1AP	SKCM	chr1	28887878	28887878	C	A	Missense_Mutation	p.N82K	1
TRNAU1AP	LIHC	chr1	28893884	28893884	G	-	Frame_Shift_Del	p.L163fs	1
TRNAU1AP	READ	chr1	28893924	28893924	G	A	Missense_Mutation	p.A177T	1
TRNAU1AP	TGCT	chr1	28891260	28891260	T	C	Silent		1

Copy number variation (CNV) of TRNAU1AP
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TRNAU1AP
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
85965	N/A	AA360336	CYP20A1	chr2	204169478	+	TRNAU1AP	chr1	28899769	-
85965	OV	TCGA-24-1544-01A	EPB41	chr1	29241280	+	TRNAU1AP	chr1	28880152	+
85965	BLCA	TCGA-DK-A6B2	GMEB1	chr1	29019557	+	TRNAU1AP	chr1	28887144	+
85965	BLCA	TCGA-DK-A6B2-01A	GMEB1	chr1	29019557	+	TRNAU1AP	chr1	28887145	+
85965	BRCA	TCGA-A7-A26G	GMEB1	chr1	28995351	+	TRNAU1AP	chr1	28897687	+
85965	BRCA	TCGA-A7-A26G-01A	GMEB1	chr1	28995351	+	TRNAU1AP	chr1	28897688	+
85965	OV	TCGA-24-2023	GMEB1	chr1	28995351	+	TRNAU1AP	chr1	28898378	+
85965	OV	TCGA-24-2023-01A	GMEB1	chr1	28995351	+	TRNAU1AP	chr1	28898379	+
85965	N/A	BE008614	KIF26B	chr1	245349460	-	TRNAU1AP	chr1	28893865	+
85965	N/A	BE008620	KIF26B	chr1	245349463	-	TRNAU1AP	chr1	28893865	+
85965	KIRC	TCGA-B0-5119-01A	NOL9	chr1	6601890	-	TRNAU1AP	chr1	28904012	+
85965	KIRC	TCGA-B0-5119-01A	NOL9	chr1	6609631	-	TRNAU1AP	chr1	28904012	+
85965	STAD	TCGA-BR-4357	PHACTR4	chr1	28733974	+	TRNAU1AP	chr1	28880151	+
85965	STAD	TCGA-CD-8525-01A	PHACTR4	chr1	28696336	+	TRNAU1AP	chr1	28897688	+
85965	Non-Cancer	TCGA-IC-A6RE-11A	RCC1	chr1	28832596	+	TRNAU1AP	chr1	28891214	+
85969	N/A	AW298043	SPOP	chr17	47677549	+	TRNAU1AP	chr1	28904053	+
94329	N/A	AA745507	TRNAU1AP	chr1	28902056	+	EPB41	chr1	29374809	+
94329	KIRC	TCGA-B0-5119-01A	TRNAU1AP	chr1	28898412	+	NOL9	chr1	6593501	-
94329	BRCA	TCGA-AO-A1KR-01A	TRNAU1AP	chr1	28880249	-	PHACTR4	chr1	28800066	+
94329	COAD	TCGA-D5-6931	TRNAU1AP	chr1	28880249	+	PTPRU	chr1	29618380	+
94329	COAD	TCGA-D5-6931-01A	TRNAU1AP	chr1	28880249	+	PTPRU	chr1	29618381	+
94329	BRCA	TCGA-C8-A134-01A	TRNAU1AP	chr1	28893925	+	RCC1	chr1	28861562	+
100607	Non-Cancer	91N	TRNAU1AP	chr1	28887244	+	TIA1	chr2	70441626	-
102496	N/A	EC491219	TRNAU1AP	chr1	28884337	-	UBE2L3	chr22	21951023	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TRNAU1AP	0.00310349881382595	0.087
LUSC	TRNAU1AP	0.0114689480784761	0.31
GBM	TRNAU1AP	0.0206211061607904	0.54
LUAD	TRNAU1AP	0.0276109408750993	0.69
BRCA	TRNAU1AP	0.0333637056735481	0.8

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TRNAU1AP	0.0196477001685819	0.61
BRCA	TRNAU1AP	0.000916240740555251	0.03
HNSC	TRNAU1AP	0.0144453591196445	0.46

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source