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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: LARP1B (NCBI Gene ID:55132)

Gene Summary

Gene Summary

Gene Information	Gene Name: LARP1B
	Gene ID: 55132
	Gene Symbol	LARP1B
	Gene ID	55132
	Gene Name	La ribonucleoprotein 1B
	Synonyms	LARP2
	Cytomap	4q28.2
	Type of Gene	protein-coding
	Description	la-related protein 1BLa ribonucleoprotein domain family member 1BLa ribonucleoprotein domain family, member 2la-related protein 2
	Modification date	20200313
	UniProtAcc	Q659C4

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
LARP1B	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'LARP1B[title] AND translation [title] AND human.'

Gene	Title	PMID
LARP1B	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000326639	129003319	129003460	In-frame
ENST00000326639	129012155	129012299	In-frame
ENST00000326639	129012501	129012667	Frame-shift
ENST00000326639	129019340	129019485	Frame-shift
ENST00000326639	129035724	129035897	Frame-shift
ENST00000326639	129042980	129043343	In-frame
ENST00000326639	129083348	129083472	Frame-shift
ENST00000326639	129098026	129098062	In-frame
ENST00000326639	129100560	129100667	Frame-shift
ENST00000326639	129127582	129127692	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000326639	129003319	129003460	4908	429	569	914	72	119
ENST00000326639	129012155	129012299	4908	570	713	914	119	167
ENST00000326639	129042980	129043343	4908	1373	1735	914	387	508
ENST00000326639	129098026	129098062	4908	1860	1895	914	549	561

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	LARP1B	1.33815746051579	0.000172235302272547
CHOL	LARP1B	-4.70275403182968	0.00390625
KICH	LARP1B	2.62138492218361	1.0073184967041e-05
LIHC	LARP1B	-1.4428316113072	1.92112539203419e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
KICH	LARP1B	hsa-miR-15b-5p	95	0.414595999253048	0.000145436673808623
SKCM	LARP1B	hsa-miR-424-5p	96	-0.446859785783836	4.41130881997423e-05

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PAAD	LARP1B	-0.173792839	0.005049353

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with LARP1B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	LARP1B	ALDH6A1	0.804015367	2.91E-11
CHOL	Cell metabolism gene	LARP1B	GLUD2	0.809380271	1.70E-11
CHOL	Cell metabolism gene	LARP1B	RETSAT	0.834954353	1.01E-12
CHOL	Cell metabolism gene	LARP1B	SEC24B	0.838953777	6.20E-13
CHOL	IUPHAR	LARP1B	TRIB1	0.802454475	3.40E-11
CHOL	IUPHAR	LARP1B	SLC39A14	0.813567146	1.10E-11
CHOL	IUPHAR	LARP1B	KCNN2	0.81883505	6.30E-12
CHOL	IUPHAR	LARP1B	F11	0.824242456	3.48E-12
CHOL	IUPHAR	LARP1B	FOLH1	0.84334014	3.59E-13
CHOL	Kinase	LARP1B	TRIB1	0.802454475	3.40E-11
CHOL	TF	LARP1B	ARID3C	0.802656026	3.33E-11
CHOL	TSG	LARP1B	PGRMC2	0.821889041	4.51E-12
DLBC	IUPHAR	LARP1B	SLC4A7	0.852703769	1.45E-14
TGCT	Cell metabolism gene	LARP1B	SLC25A16	0.816892235	1.23E-38
TGCT	Epifactor	LARP1B	PRDM14	0.841979472	4.06E-43
TGCT	IUPHAR	LARP1B	HCN2	0.801930396	2.81E-36
TGCT	IUPHAR	LARP1B	SLC45A4	0.802567147	2.25E-36
TGCT	IUPHAR	LARP1B	GJA10	0.808727972	2.53E-37
TGCT	IUPHAR	LARP1B	NSMAF	0.811415847	9.51E-38
TGCT	IUPHAR	LARP1B	SLC25A16	0.816892235	1.23E-38
TGCT	IUPHAR	LARP1B	NLRP7	0.820220962	3.44E-39
TGCT	IUPHAR	LARP1B	KCNG3	0.835845141	5.94E-42
TGCT	TF	LARP1B	MYBL2	0.801614671	3.13E-36
TGCT	TF	LARP1B	ZNF589	0.810537613	1.31E-37
TGCT	TF	LARP1B	ZNF578	0.810736509	1.22E-37
TGCT	TF	LARP1B	NFE2L3	0.811312883	9.87E-38
TGCT	TF	LARP1B	ZNF675	0.824467094	6.50E-40
TGCT	TF	LARP1B	NANOG	0.828492466	1.29E-40
TGCT	TF	LARP1B	PRDM14	0.841979472	4.06E-43
THYM	Cell metabolism gene	LARP1B	PIKFYVE	0.801807862	1.33E-28
THYM	IUPHAR	LARP1B	PIKFYVE	0.801807862	1.33E-28
UCS	Cell metabolism gene	LARP1B	PIKFYVE	0.801807862	1.33E-28
UCS	IUPHAR	LARP1B	PIKFYVE	0.801807862	1.33E-28
UVM	Cell metabolism gene	LARP1B	PNPLA8	0.800435234	5.14E-19
UVM	Cell metabolism gene	LARP1B	PPP1CB	0.807726976	1.40E-19
UVM	Cell metabolism gene	LARP1B	CSGALNACT2	0.81284459	5.42E-20
UVM	Cell metabolism gene	LARP1B	PLA2G12A	0.816784702	2.56E-20
UVM	Cell metabolism gene	LARP1B	SEC24B	0.819664584	1.46E-20
UVM	Cell metabolism gene	LARP1B	GXYLT1	0.820271753	1.30E-20
UVM	Cell metabolism gene	LARP1B	MANEA	0.821506948	1.02E-20
UVM	Cell metabolism gene	LARP1B	DCK	0.839518234	2.31E-22
UVM	Cell metabolism gene	LARP1B	ENOPH1	0.849540787	2.28E-23
UVM	Cell metabolism gene	LARP1B	FBXW7	0.854808071	6.31E-24
UVM	Cell metabolism gene	LARP1B	NUP54	0.856699084	3.93E-24
UVM	CGC	LARP1B	TET2	0.804292312	2.60E-19
UVM	CGC	LARP1B	STAG2	0.811239457	7.31E-20
UVM	CGC	LARP1B	PHF6	0.82662573	3.63E-21
UVM	CGC	LARP1B	MLLT10	0.836877249	4.14E-22
UVM	CGC	LARP1B	FBXW7	0.854808071	6.31E-24
UVM	CGC	LARP1B	MALT1	0.858728961	2.35E-24
UVM	Epifactor	LARP1B	TET2	0.804292312	2.60E-19
UVM	Epifactor	LARP1B	UBE2D3	0.806955349	1.61E-19
UVM	Epifactor	LARP1B	CUL2	0.810512173	8.37E-20
UVM	Epifactor	LARP1B	YEATS4	0.822462286	8.41E-21
UVM	Epifactor	LARP1B	RMI1	0.82530371	4.75E-21
UVM	Epifactor	LARP1B	ZMYND11	0.825392865	4.66E-21
UVM	Epifactor	LARP1B	MLLT10	0.836877249	4.14E-22
UVM	IUPHAR	LARP1B	XIAP	0.804237254	2.62E-19
UVM	IUPHAR	LARP1B	NEK7	0.812444218	5.84E-20
UVM	IUPHAR	LARP1B	PLA2G12A	0.816784702	2.56E-20
UVM	IUPHAR	LARP1B	STK38L	0.821977799	9.26E-21
UVM	IUPHAR	LARP1B	SLK	0.822965107	7.61E-21
UVM	IUPHAR	LARP1B	ZMYND11	0.825392865	4.66E-21
UVM	IUPHAR	LARP1B	BIRC2	0.846310567	4.90E-23
UVM	IUPHAR	LARP1B	MALT1	0.858728961	2.35E-24
UVM	IUPHAR	LARP1B	NEK1	0.867498714	2.29E-25
UVM	Kinase	LARP1B	NEK7	0.812444218	5.84E-20
UVM	Kinase	LARP1B	STK38L	0.821977799	9.26E-21
UVM	Kinase	LARP1B	SLK	0.822965107	7.61E-21
UVM	Kinase	LARP1B	NEK1	0.867498714	2.29E-25
UVM	TF	LARP1B	GABPA	0.800916543	4.73E-19
UVM	TF	LARP1B	DMTF1	0.802312421	3.70E-19
UVM	TF	LARP1B	TET2	0.804292312	2.60E-19
UVM	TF	LARP1B	ZNF585A	0.804919359	2.32E-19
UVM	TF	LARP1B	ZNF248	0.805290756	2.17E-19
UVM	TF	LARP1B	ZNF25	0.806399903	1.78E-19
UVM	TF	LARP1B	THAP5	0.808906368	1.13E-19
UVM	TF	LARP1B	ZNF33A	0.809101704	1.09E-19
UVM	TF	LARP1B	ZNF606	0.809297192	1.05E-19
UVM	TF	LARP1B	IKZF5	0.813878118	4.46E-20
UVM	TF	LARP1B	ZNF432	0.8219591	9.30E-21
UVM	TF	LARP1B	ZNF567	0.823023233	7.52E-21
UVM	TF	LARP1B	ZFX	0.823147116	7.33E-21
UVM	TF	LARP1B	LIN54	0.838581706	2.84E-22
UVM	TF	LARP1B	THAP9	0.85470732	6.47E-24
UVM	TF	LARP1B	THAP6	0.861581764	1.12E-24
UVM	TF	LARP1B	ELF2	0.86264227	8.48E-25
UVM	TSG	LARP1B	DMTF1	0.802312421	3.70E-19
UVM	TSG	LARP1B	TET2	0.804292312	2.60E-19
UVM	TSG	LARP1B	CUL2	0.810512173	8.37E-20
UVM	TSG	LARP1B	VEZT	0.817426812	2.26E-20
UVM	TSG	LARP1B	ZMYND11	0.825392865	4.66E-21
UVM	TSG	LARP1B	PHF6	0.82662573	3.63E-21
UVM	TSG	LARP1B	TANK	0.828170883	2.64E-21
UVM	TSG	LARP1B	RCHY1	0.840158876	2.00E-22
UVM	TSG	LARP1B	FBXW7	0.854808071	6.31E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	LARP1B	MAN1A2	-1.98471015502085	0.00109657614318825
ESCA	LARP1B	TMEM206	-1.78920247135457	0.001953125
CHOL	LARP1B	PABPC1	-4.56272528815353	0.00390625
CHOL	LARP1B	PGRMC2	-13.1236641581537	0.00390625
CHOL	LARP1B	TMEM206	-3.00191382168402	0.00390625
CHOL	LARP1B	UBAP2	-4.31861641957003	0.00390625
LUSC	LARP1B	PGRMC2	1.02839886865035	0.00406635823555482
BLCA	LARP1B	LARP1	-3.14511945488335	0.0108261108398438
LUSC	LARP1B	NENF	-1.62265429300526	0.0109310209423722
KIRC	LARP1B	NENF	-2.25490885407538	0.0156992148165757
BLCA	LARP1B	PABPC1	1.31485302792746	0.0180816650390625
READ	LARP1B	TMEM206	-4.72330530333926	0.03125
HNSC	LARP1B	UBAP2	1.17098855651331	0.038631391710851
KIRP	LARP1B	UBAP2	-1.21754411334196	0.0394268441013992
KIRP	LARP1B	MAN1A2	-3.39240120179873	0.0413399673998356
LUAD	LARP1B	NENF	-3.27231699663375	0.0417265102143948
PRAD	LARP1B	LARP1	-4.32858209458213	1.02977929185394e-06
STAD	LARP1B	PGRMC2	-3.32233218570352	1.60322524607182e-05
KICH	LARP1B	PGRMC2	2.93329594389484	1.78813934326172e-07
PRAD	LARP1B	TMEM206	-3.13038768113216	2.79265505746968e-06
LIHC	LARP1B	LARP1	-2.87067203862976	2.96133940972468e-07
LIHC	LARP1B	PABPC1	-1.72076961362188	2.98009622125841e-06
COAD	LARP1B	TMEM206	-5.78174860074785	2.98023223876954e-08
STAD	LARP1B	TMEM206	-1.56510840876939	4.09781932830811e-08
STAD	LARP1B	UBAP2	2.31812548539395	5.24520874023438e-06
LIHC	LARP1B	TMEM206	-1.10549160095543	5.52349441012722e-09
PRAD	LARP1B	PABPC1	-2.10200318363476	8.55379952759014e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with LARP1B

ELAVL1, CUL3, APP, UBC, POLR2J, KIF2A, TRIM69, CCNI2, TRA2A, NIFK, RPS2, ZC3H3, HNRNPA1, LUC7L2, CCNG1, POC1A, Rpl35, GSPT2, LARP1, ELAVL2, CDX1, DGCR8, H2AFX, APOBEC3D, WDR46, HIST1H1E, SNRNP70, MEPCE, LARP7, SERBP1, FBL, GSK3B, RC3H1, BRD7, TBC1D25, PIBF1, MRPL28, MEOX2, RBBP8NL, RABIF, HIST1H4A, DAZL, LARP4B, MKRN2, PABPC1, CAPRIN1, FXR1, LSM14A, CTIF, DDX19B, MOV10, IGF2BP2, SYNCRIP, ECT2, KIF23, EXD2, RBM39, DDRGK1, ACTB, RPS20, FZR1, FAM120A, ZBTB47, YBX2, PURG, HIST1H1D, FGF17, GLI4, PRR3, HNRNPUL2, REXO4, HNRNPC, LIN28B, CCDC140, RPL26, HNRNPCL2, HNRNPCL1, ZFC3H1, RPS3A, PABPC5, OASL, RBMS2, HNRNPU, LIN28A, H1FNT, SRSF6, PAIP2B, RPL23AP32, NEIL1, PER1, ZNF346, MAP7, HIST1H1B, RSL1D1, RPS6, MYBBP1A, RPL31, RPS19, RPL17, YBX1, RNF151, RPS3, IGF2BP3, CBX6, SURF6, NOG, NUPL2, THAP3, SRSF4, ILF3, PTBP3, SRSF3, SRSF5, RPLP0, RBM47, SRSF7, RPSAP58, CLK3, ILF2, ABT1, MAGEB2, SRSF1, RPSA, RPL19, RPL36AL, HIST1H1A, PAIP1, RPS10, MSLN, Nudt21,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
LARP1B	chr4	129043143	G	T	single_nucleotide_variant	Uncertain_significance	Malignant_tumor_of_prostate	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
LARP1B	HNSC	chr4	129043203	129043203	C	T	Missense_Mutation	p.P462S	4
LARP1B	PAAD	chr4	129043322	129043322	A	T	Missense_Mutation	p.E501D	3
LARP1B	HNSC	chr4	129043203	129043203	C	T	Missense_Mutation		3
LARP1B	CESC	chr4	129012266	129012266	C	T	Missense_Mutation	p.R157W	3
LARP1B	UCEC	chr4	129019450	129019450	C	T	Nonsense_Mutation	p.Q260*	3
LARP1B	UCEC	chr4	129035883	129035883	C	A	Missense_Mutation	p.P383T	3
LARP1B	UCEC	chr4	129035811	129035811	G	T	Missense_Mutation	p.G359C	3
LARP1B	UCEC	chr4	129127662	129127662	C	T	Nonsense_Mutation	p.Q797*	3
LARP1B	PAAD	chr4	129012165	129012165	G	A	Missense_Mutation	p.R123Q	3
LARP1B	UCS	chr4	129128488	129128488	C	T	Missense_Mutation	p.L833F	3
LARP1B	LIHC	chr4	128999091	128999091	C	G	Missense_Mutation		2
LARP1B	UCEC	chr4	129043089	129043089	C	T	Nonsense_Mutation	p.R424*	2
LARP1B	CESC	chr4	129098043	129098043	G	T	Silent		2
LARP1B	KIRC	chr4	129098058	129098058	G	A	Silent	p.K560K	2
LARP1B	LUAD	chr4	129043061	129043061	G	T	Missense_Mutation	p.L414F	2
LARP1B	LIHC	chr4	128999091	128999091	C	G	Missense_Mutation	p.A64G	2
LARP1B	STAD	chr4	129012197	129012197	G	A	Missense_Mutation	p.V134I	2
LARP1B	SARC	chr4	129012526	129012526	A	T	Missense_Mutation		2
LARP1B	UCEC	chr4	129043185	129043185	C	T	Missense_Mutation	p.P456S	2
LARP1B	CESC	chr4	129100652	129100652	G	C	Missense_Mutation	p.G663A	2
LARP1B	ESCA	chr4	128999117	128999117	G	T	Missense_Mutation	p.A73S	2
LARP1B	UCEC	chr4	129099656	129099656	G	A	Silent	p.S585	2
LARP1B	SARC	chr4	129100643	129100643	G	A	Missense_Mutation		2
LARP1B	SKCM	chr4	129120711	129120711	T	C	Silent	p.F707F	2
LARP1B	UCEC	chr4	129099702	129099702	A	G	Missense_Mutation	p.T601A	2
LARP1B	KIRP	chr4	129083352	129083352	G	T	Nonsense_Mutation		2
LARP1B	STAD	chr4	129012184	129012184	T	C	Silent	p.D129D	2
LARP1B	ESCA	chr4	128999117	128999117	G	T	Missense_Mutation		2
LARP1B	SARC	chr4	129012526	129012526	A	T	Missense_Mutation	p.Y176F	2
LARP1B	SKCM	chr4	129128529	129128529	C	T	Silent	p.F846F	2
LARP1B	UCEC	chr4	129099766	129099766	T	C	Missense_Mutation	p.V622A	2
LARP1B	STAD	chr4	129121797	129121797	G	T	Missense_Mutation	p.W762C	2
LARP1B	BRCA	chr4	129043387	129043387	G	C	Nonstop_Mutation	p.L491F	2
LARP1B	HNSC	chr4	129043065	129043065	G	A	Missense_Mutation		2
LARP1B	SKCM	chr4	129012229	129012229	C	T	Silent	p.I144I	2
LARP1B	SKCM	chr4	129099679	129099679	C	T	Missense_Mutation	p.S593F	2
LARP1B	UCEC	chr4	129120621	129120621	C	T	Silent	p.G677	2
LARP1B	BRCA	chr4	129043387	129043387	G	C	Nonsense_Mutation	p.*523S	2
LARP1B	SKCM	chr4	129043225	129043225	C	T	Missense_Mutation	p.T469I	2
LARP1B	SKCM	chr4	129120679	129120679	C	T	Missense_Mutation	p.P697S	2
LARP1B	UCEC	chr4	129120747	129120747	C	T	Silent	p.C719	2
LARP1B	KIRC	chr4	129121753	129121753	C	A	Missense_Mutation	p.H748N	2
LARP1B	STAD	chr4	129121762	129121762	A	-	Frame_Shift_Del	p.K751fs	2
LARP1B	CESC	chr4	129120696	129120696	G	A	Silent		2
LARP1B	SKCM	chr4	129120680	129120680	C	T	Missense_Mutation	p.P697L	2
LARP1B	UCEC	chr4	129012544	129012544	G	T	Missense_Mutation	p.R182M	2
LARP1B	UCEC	chr4	129131184	129131184	G	A	Silent	p.P907	2
LARP1B	CESC	chr4	129100652	129100652	G	C	Missense_Mutation		2
LARP1B	LUAD	chr4	129012285	129012285	G	T	Missense_Mutation	p.R163I	2
LARP1B	UCEC	chr4	129019373	129019373	G	A	Missense_Mutation	p.R234Q	2
LARP1B	LIHC	chr4	129028308	129028308	C	A	Missense_Mutation		2
LARP1B	PAAD	chr4	129043322	129043322	A	T	Missense_Mutation		2
LARP1B	LIHC	chr4	129035772	129035772	A	-	Frame_Shift_Del	p.K346fs	2
LARP1B	CESC	chr4	129019476	129019476	C	T	Silent		2
LARP1B	HNSC	chr4	129043274	129043274	T	C	Silent	p.N485N	2
LARP1B	KIRC	chr4	129043237	129043237	G	C	Missense_Mutation	p.R473P	2
LARP1B	SKCM	chr4	129035873	129035873	T	C	Silent	p.H379H	2
LARP1B	UCEC	chr4	129028409	129028409	T	C	Missense_Mutation	p.F310S	2
LARP1B	BLCA	chr4	129043216	129043216	G	C	Missense_Mutation	p.R466P	2
LARP1B	LIHC	chr4	129131107	129131107	C	-	Frame_Shift_Del	p.P883fs	2
LARP1B	CESC	chr4	129012266	129012266	C	T	Missense_Mutation		2
LARP1B	KIRC	chr4	129012653	129012653	T	C	Silent	p.Y218Y	2
LARP1B	LUAD	chr4	129043234	129043234	C	G	Missense_Mutation	p.S472C	2
LARP1B	UCEC	chr4	129035799	129035799	G	T	Missense_Mutation	p.A355S	2
LARP1B	SKCM	chr4	129127673	129127673	C	A	Silent	p.T800T	1
LARP1B	BLCA	chr4	129043216	129043216	G	C	Missense_Mutation		1
LARP1B	COAD	chr4	129019465	129019465	A	G	Missense_Mutation	p.N265D	1
LARP1B	BLCA	chr4	129019483	129019483	G	C	Missense_Mutation	p.E271Q	1
LARP1B	LIHC	chr4	129043162	129043162	T	-	Frame_Shift_Del	p.I448fs	1
LARP1B	SARC	chr4	129035764	129035764	G	T	Missense_Mutation		1
LARP1B	THCA	chr4	129099611	129099611	G	T	Missense_Mutation		1
LARP1B	HNSC	chr4	129131155	129131155	A	T	Missense_Mutation	p.I898L	1
LARP1B	SKCM	chr4	129131171	129131171	G	A	Missense_Mutation	p.R903K	1
LARP1B	PAAD	chr4	128999013	128999013	A	C	Missense_Mutation	p.K38T	1
LARP1B	BLCA	chr4	128996104	128996104	G	C	Missense_Mutation		1
LARP1B	DLBC	chr4	129035899	129035899	T	C	Splice_Site	.	1
LARP1B	BLCA	chr4	129128527	129128527	T	C	Missense_Mutation	p.F846L	1
LARP1B	HNSC	chr4	129003419	129003419	C	T	Missense_Mutation		1
LARP1B	LIHC	chr4	129100622	129100622	G	-	Frame_Shift_Del	p.W653fs	1
LARP1B	UCEC	chr4	129127690	129127690	C	T	Missense_Mutation	p.S806F	1
LARP1B	SKCM	chr4	129121743	129121743	C	T	Silent	p.F744F	1
LARP1B	KIRP	chr4	128998994	128998994	A	C	Missense_Mutation	p.K32Q	1
LARP1B	LUAD	chr4	129035746	129035746	G	A	Missense_Mutation	p.R337K	1
LARP1B	LIHC	chr4	129028308	129028308	C	A	Missense_Mutation	p.S276R	1
LARP1B	PAAD	chr4	129128500	129128500	C	A	Missense_Mutation	p.L837I	1
LARP1B	STAD	chr4	129121762	129121762	A	-	Frame_Shift_Del	p.N750fs	1
LARP1B	BLCA	chr4	129012638	129012638	A	G	Silent		1
LARP1B	BLCA	chr4	129127589	129127589	G	C	Silent	p.G772G	1
LARP1B	HNSC	chr4	129043204	129043204	C	G	Missense_Mutation		1
LARP1B	LIHC	chr4	129131037	129131037	A	-	Frame_Shift_Del	p.R858fs	1
LARP1B	SARC	chr4	129012245	129012245	G	T	Missense_Mutation		1
LARP1B	UCEC	chr4	129128537	129128537	A	G	Missense_Mutation	p.D849_splice	1
LARP1B	SKCM	chr4	129042981	129042981	G	T	Splice_Site	p.E388_splice	1
LARP1B	HNSC	chr4	129043065	129043065	G	A	Missense_Mutation	p.D416N	1
LARP1B	KIRP	chr4	128999004	128999004	A	G	Missense_Mutation	p.K35R	1
LARP1B	LUAD	chr4	129012218	129012218	G	T	Missense_Mutation	p.G141C	1
LARP1B	LIHC	chr4	129127685	129127685	C	A	Nonsense_Mutation	p.Y804X	1
LARP1B	PRAD	chr4	129121699	129121699	C	T	Nonsense_Mutation	p.Q730*	1
LARP1B	STAD	chr4	129127626	129127627	-	A	Frame_Shift_Ins	p.E785fs	1
LARP1B	BLCA	chr4	129043286	129043286	C	T	Silent		1
LARP1B	ESCA	chr4	129120737	129120737	G	T	Missense_Mutation	p.R716L	1
LARP1B	BLCA	chr4	129043145	129043145	C	T	Silent	p.D442D	1
LARP1B	HNSC	chr4	129012524	129012524	T	C	Silent		1
LARP1B	LIHC	chr4	129003340	129003340	C	-	Frame_Shift_Del	p.P80fs	1
LARP1B	SKCM	chr4	129131132	129131132	C	T	Missense_Mutation	p.S890F	1
LARP1B	CESC	chr4	129100541	129100541	C	G	RNA	NULL	1
LARP1B	HNSC	chr4	129121769	129121769	T	-	Frame_Shift_Del	p.M753fs	1
LARP1B	LUAD	chr4	129012520	129012520	A	G	Missense_Mutation	p.Y174C	1
LARP1B	LIHC	chr4	129019441	129019441	C	T	Nonsense_Mutation	p.Q257X	1
LARP1B	READ	chr4	129012668	129012668	G	A	Splice_Site	.	1
LARP1B	BLCA	chr4	129019483	129019483	G	C	Missense_Mutation		1
LARP1B	BLCA	chr4	129003369	129003369	G	C	Missense_Mutation	p.E89D	1
LARP1B	HNSC	chr4	129120715	129120715	C	A	Missense_Mutation		1
LARP1B	LIHC	chr4	129028477	129028477	T	-	Frame_Shift_Del	p.F333fs	1
LARP1B	SKCM	chr4	129120748	129120748	C	T	Silent	p.L720L	1
LARP1B	CESC	chr4	129120696	129120696	G	A	Silent	p.L702	1
LARP1B	KIRC	chr4	129128464	129128464	A	G	Missense_Mutation	p.K825E	1
LARP1B	LGG	chr4	129012278	129012278	C	T	Nonsense_Mutation	p.R161*	1
LARP1B	LUSC	chr4	129127647	129127647	A	G	Missense_Mutation	p.I792V	1
LARP1B	LIHC	chr4	128999019	128999019	G	-	Frame_Shift_Del	p.S40fs	1
LARP1B	READ	chr4	129043135	129043135	A	C	Missense_Mutation	p.E439A	1
LARP1B	BLCA	chr4	129099690	129099690	C	A	Missense_Mutation		1
LARP1B	ESCA	chr4	129120737	129120737	G	T	Missense_Mutation		1
LARP1B	LIHC	chr4	129121709	129121709	A	-	Frame_Shift_Del	p.E733fs	1
LARP1B	SKCM	chr4	129120747	129120747	C	T	Silent	p.C719C	1
LARP1B	COAD	chr4	129035844	129035844	G	T	Nonsense_Mutation	p.E370X	1
LARP1B	KIRC	chr4	129127627	129127627	A	-	Frame_Shift_Del	p.E785fs	1
LARP1B	LGG	chr4	129012278	129012278	C	T	Missense_Mutation		1
LARP1B	LUSC	chr4	129035746	129035746	G	C	Missense_Mutation	p.R337T	1
LARP1B	LIHC	chr4	129028555	129028555	T	G	Missense_Mutation	p.X359E	1
LARP1B	READ	chr4	129099718	129099718	G	A	Missense_Mutation	p.R606Q	1
LARP1B	STAD	chr4	129043260	129043260	G	T	Missense_Mutation	p.A481S	1
LARP1B	BLCA	chr4	129128527	129128527	T	C	Missense_Mutation		1
LARP1B	GBM	chr4	129003366	129003366	A	G	Silent	p.S88S	1
LARP1B	HNSC	chr4	129131155	129131155	A	T	Missense_Mutation		1
LARP1B	LIHC	chr4	128998992	128998992	A	-	Frame_Shift_Del	p.E31fs	1
LARP1B	SKCM	chr4	129043343	129043343	G	A	Splice_Site	p.K508_splice	1
LARP1B	COAD	chr4	129043216	129043216	G	A	Missense_Mutation	p.R466Q	1
LARP1B	LGG	chr4	129028412	129028412	C	A	Missense_Mutation		1
LARP1B	LUSC	chr4	129012165	129012165	G	T	Missense_Mutation	p.R123L	1
LARP1B	LIHC	chr4	129043173	129043173	A	G	Missense_Mutation	p.T452A	1
LARP1B	READ	chr4	128999036	128999036	G	T	Nonsense_Mutation	p.E46X	1
LARP1B	BLCA	chr4	129127589	129127589	G	C	Silent		1
LARP1B	GBM	chr4	128999066	128999066	G	C	Missense_Mutation	p.G56R	1
LARP1B	HNSC	chr4	129012524	129012524	T	C	Silent	p.G175G	1
LARP1B	LIHC	chr4	129083423	129083423	T	-	Frame_Shift_Del	p.P533fs	1
LARP1B	SKCM	chr4	129099585	129099585	G	A	Splice_Site		1
LARP1B	COAD	chr4	129120606	129120606	T	G	Silent	p.A672A	1
LARP1B	KIRC	chr4	129003396	129003396	C	A	Missense_Mutation	p.N98K	1
LARP1B	LIHC	chr4	129003375	129003375	A	G	Silent		1
LARP1B	PAAD	chr4	129012181	129012181	G	A	Silent		1
LARP1B	LIHC	chr4	129043193	129043194	-	A	Frame_Shift_Ins	p.VK458fs	1
LARP1B	READ	chr4	129028332	129028332	G	T	Missense_Mutation	p.E284D	1
LARP1B	STAD	chr4	129127627	129127628	-	A	Frame_Shift_Ins	p.E785fs	1
LARP1B	BLCA	chr4	129043145	129043145	C	T	Silent		1
LARP1B	GBM	chr4	128999066	128999066	G	C	Missense_Mutation		1
LARP1B	HNSC	chr4	129003419	129003419	C	T	Missense_Mutation	p.A106V	1
LARP1B	SKCM	chr4	129127653	129127653	C	T	Nonsense_Mutation	p.Q794X	1
LARP1B	SKCM	chr4	129120688	129120688	G	A	Missense_Mutation	p.E700K	1
LARP1B	UCS	chr4	129128488	129128488	C	T	Missense_Mutation		1
LARP1B	COAD	chr4	129120708	129120708	C	T	Silent	p.G706G	1
LARP1B	HNSC	chr4	129043120	129043120	A	C	Missense_Mutation		1
LARP1B	READ	chr4	129121708	129121708	G	T	Nonsense_Mutation	p.E733X	1
LARP1B	THCA	chr4	129028485	129028485	T	G	Silent		1
LARP1B	BLCA	chr4	129003369	129003369	G	C	Missense_Mutation		1
LARP1B	LUAD	chr4	128998985	128998985	A	G	Missense_Mutation	p.R29G	1
LARP1B	LIHC	chr4	129100622	129100622	G	T	Missense_Mutation		1
LARP1B	SKCM	chr4	129012157	129012157	T	C	Splice_Site	p.S120_splice	1
LARP1B	COAD	chr4	129120719	129120719	A	C	Missense_Mutation	p.Q710P	1
LARP1B	HNSC	chr4	129043274	129043274	T	C	Silent		1
LARP1B	SARC	chr4	129012243	129012243	G	T	Missense_Mutation		1
LARP1B	THCA	chr4	129099645	129099645	A	G	Translation_Start_Site		1
LARP1B	HNSC	chr4	129043120	129043120	A	C	Missense_Mutation	p.N434T	1
LARP1B	SKCM	chr4	129127653	129127653	C	T	Nonsense_Mutation	p.Q794*	1

Copy number variation (CNV) of LARP1B
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across LARP1B
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97209	N/A	BP432766	DHFR	chr5	79946482	-	LARP1B	chr4	129002937	-
97209	N/A	EC564330	INTU	chr4	128627992	+	LARP1B	chr4	129011057	+
99845	N/A	BX107631	LARP1B	chr4	129003378	+	BTG3	chr21	18966628	-
44121	BLCA	TCGA-XF-A9SP-01A	LARP1B	chr4	129012667	-	C4orf29	chr4	128956917	+
102349	N/A	EC518035	LARP1B	chr4	128995310	-	CDKAL1	chr6	20597971	-
101994	N/A	BF873944	LARP1B	chr4	128999075	-	FBLN1	chr22	45929052	-
44121	N/A	AA714879	LARP1B	chr4	129017950	-	INTU	chr4	128619391	-
97209	N/A	AI652589	LARP1B	chr4	129012262	-	LARP1B	chr4	129097226	-
97209	N/A	EB362731	LARP1B	chr4	128995615	-	LARP1B	chr4	129003460	-
92801	N/A	EC447226	LARP1B	chr4	129002937	+	MTRNR2L1	chr17	22022809	-
44121	N/A	EC583628	LARP1B	chr4	129002937	+	MTRNR2L12	chr3	96336695	+
44121	STAD	TCGA-BR-8590-01A	LARP1B	chr4	129028468	+	SLC25A31	chr4	128665827	+
76712	Non-Cancer	ERR315487	LARP1B	chr4	129043343	+	THAP9	chr4	83838097	+
97209	N/A	EC529075	LRRTM3	chr10	68773155	+	LARP1B	chr4	128995629	+
97209	N/A	EC558777	MTRNR2L12	chr3	96336695	-	LARP1B	chr4	129002937	-
97209	STAD	TCGA-KB-A6F7	PHF17	chr4	129752965	+	LARP1B	chr4	129083348	+
97209	STAD	TCGA-KB-A6F7	PHF17	chr4	129752965	+	LARP1B	chr4	129099585	+
97209	STAD	TCGA-KB-A6F7	PHF17	chr4	129752965	+	LARP1B	chr4	129100560	+
97209	STAD	TCGA-KB-A6F7-01A	PHF17	chr4	129752965	-	LARP1B	chr4	129083349	+
97209	N/A	AA713933	RGS6	chr14	73087784	+	LARP1B	chr4	129103262	-
97209	N/A	AW023530	RPL37A	chr2	217366190	+	LARP1B	chr4	128983772	-
97209	N/A	AA303012	S100A11	chr1	152005172	+	LARP1B	chr4	129029795	-
97209	N/A	CB048112	SBF2-AS1	chr11	9814506	+	LARP1B	chr4	128998983	-
97209	N/A	EC558791	SPECC1	chr17	20169680	+	LARP1B	chr4	129039687	-
97215	OV	TCGA-24-2024	USP14	chr18	166819	+	LARP1B	chr4	129028293	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	LARP1B	0.000129409020481428	0.0035
THYM	LARP1B	0.00483594772972764	0.13
LIHC	LARP1B	0.029788795861822	0.74
PCPG	LARP1B	0.0305095097111376	0.74
STAD	LARP1B	0.033790609337206	0.78
HNSC	LARP1B	0.0483966959032874	1
LUAD	LARP1B	5.34885742164016e-05	0.0015

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	LARP1B	0.000741722035363811	0.024
LUSC	LARP1B	0.000839131211634128	0.027
THCA	LARP1B	0.00715725984660119	0.21
LAML	LARP1B	0.00495063490089001	0.15
ESCA	LARP1B	0.00682287596117645	0.2

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source