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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DNAJC3 (NCBI Gene ID:5611)

Gene Summary

Gene Summary

Gene Information	Gene Name: DNAJC3
	Gene ID: 5611
	Gene Symbol	DNAJC3
	Gene ID	5611
	Gene Name	DnaJ heat shock protein family (Hsp40) member C3
	Synonyms	ACPHD\|ERdj6\|HP58\|P58\|P58IPK\|PRKRI\|p58(IPK)
	Cytomap	13q32.1
	Type of Gene	protein-coding
	Description	dnaJ homolog subfamily C member 3DnaJ (Hsp40) homolog, subfamily C, member 3ER-resident protein ERdj6endoplasmic reticulum DNA J domain-containing protein 6interferon-induced, double-stranded RNA-activated protein kinase inhibitorprotein kinase inhib
	Modification date	20200329
	UniProtAcc	Q13217

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DNAJC3	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DNAJC3[title] AND translation [title] AND human.'

Gene	Title	PMID
DNAJC3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000602402	96377431	96377506	In-frame
ENST00000602402	96409897	96410050	In-frame
ENST00000602402	96412932	96413052	In-frame
ENST00000602402	96438192	96438325	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000602402	96377431	96377506	5608	436	510	504	106	131
ENST00000602402	96409897	96410050	5608	511	663	504	131	182
ENST00000602402	96412932	96413052	5608	846	965	504	243	282

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q13217	243	282	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
Q13217	131	182	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
Q13217	106	131	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
Q13217	131	182	105	138	Repeat	Note=TPR 3
Q13217	106	131	105	138	Repeat	Note=TPR 3
Q13217	131	182	154	187	Repeat	Note=TPR 4
Q13217	243	282	222	255	Repeat	Note=TPR 6
Q13217	243	282	268	301	Repeat	Note=TPR 7
Q13217	243	282	274	274	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26091039;Dbxref=PMID:26091039
Q13217	243	282	248	258	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21799829;Dbxref=PMID:21799829
Q13217	106	131	105	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T
Q13217	131	182	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T
Q13217	106	131	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T
Q13217	131	182	138	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T
Q13217	131	182	170	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T
Q13217	243	282	238	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T
Q13217	243	282	256	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y4T

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	DNAJC3	-3.44412351904465	0.0132303284481168
THCA	DNAJC3	-2.12121976415638	2.19889745410215e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LIHC	DNAJC3	hsa-miR-9-5p	97	-0.318313265681687	0.00495788133246211
UCEC	DNAJC3	hsa-miR-9-5p	97	0.383957219251337	0.0256757471718199

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LAML	DNAJC3	2	1	0.0191296790190592	0.2123621875	0.152294307692308	-0.398461397897991	-0.294541998859561

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
COAD	DNAJC3	-0.021515533	0.015861486
ESCA	DNAJC3	0.058225229	0.044566935

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DNAJC3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THCA	Cell metabolism gene	DNAJC3	SPCS3	0.826139573	3.99E-144
THCA	Cell metabolism gene	DNAJC3	CANX	0.826523243	2.26E-144
THCA	IUPHAR	DNAJC3	MAGT1	0.828769733	7.78E-146
THYM	Cell metabolism gene	DNAJC3	SEC31A	0.800559028	1.86E-28
THYM	Cell metabolism gene	DNAJC3	SEC24D	0.805418442	4.95E-29
THYM	Cell metabolism gene	DNAJC3	PGM3	0.805515981	4.81E-29
THYM	Cell metabolism gene	DNAJC3	PIGK	0.808044862	2.38E-29
THYM	Cell metabolism gene	DNAJC3	GALNT3	0.810535277	1.18E-29
THYM	Cell metabolism gene	DNAJC3	ARSB	0.811848929	8.09E-30
THYM	Cell metabolism gene	DNAJC3	SGMS2	0.812766862	6.21E-30
THYM	Cell metabolism gene	DNAJC3	LMAN1	0.821817896	4.24E-31
THYM	Cell metabolism gene	DNAJC3	SLC16A4	0.822229086	3.74E-31
THYM	Cell metabolism gene	DNAJC3	PRKAR1A	0.823487006	2.54E-31
THYM	Cell metabolism gene	DNAJC3	PIK3C2A	0.82701258	8.47E-32
THYM	Cell metabolism gene	DNAJC3	GFPT1	0.835406379	5.58E-33
THYM	Cell metabolism gene	DNAJC3	MCFD2	0.881951577	5.19E-41
THYM	Cell metabolism gene	DNAJC3	CANX	0.902699486	9.00E-46
THYM	CGC	DNAJC3	AFF4	0.80205144	1.24E-28
THYM	CGC	DNAJC3	ARHGEF12	0.807774551	2.57E-29
THYM	CGC	DNAJC3	CREB3L2	0.812771045	6.20E-30
THYM	CGC	DNAJC3	PRKAR1A	0.823487006	2.54E-31
THYM	CGC	DNAJC3	LATS2	0.83817112	2.20E-33
THYM	CGC	DNAJC3	ACVR1	0.854690036	5.79E-36
THYM	Epifactor	DNAJC3	KDM3B	0.804476168	6.41E-29
THYM	Epifactor	DNAJC3	ZMYND11	0.814804958	3.44E-30
THYM	Epifactor	DNAJC3	BMI1	0.854831527	5.48E-36
THYM	IUPHAR	DNAJC3	PREPL	0.801858055	1.31E-28
THYM	IUPHAR	DNAJC3	KDM3B	0.804476168	6.41E-29
THYM	IUPHAR	DNAJC3	SGMS2	0.812766862	6.21E-30
THYM	IUPHAR	DNAJC3	ZMYND11	0.814804958	3.44E-30
THYM	IUPHAR	DNAJC3	SLC35F5	0.820417184	6.48E-31
THYM	IUPHAR	DNAJC3	SLC16A4	0.822229086	3.74E-31
THYM	IUPHAR	DNAJC3	CPD	0.823418598	2.59E-31
THYM	IUPHAR	DNAJC3	PRKAR1A	0.823487006	2.54E-31
THYM	IUPHAR	DNAJC3	ITGB1	0.825950148	1.18E-31
THYM	IUPHAR	DNAJC3	PIK3C2A	0.82701258	8.47E-32
THYM	IUPHAR	DNAJC3	SLC35A5	0.828556138	5.19E-32
THYM	IUPHAR	DNAJC3	ATP2A2	0.832948871	1.26E-32
THYM	IUPHAR	DNAJC3	LATS2	0.83817112	2.20E-33
THYM	IUPHAR	DNAJC3	ACVR1	0.854690036	5.79E-36
THYM	Kinase	DNAJC3	LATS2	0.83817112	2.20E-33
THYM	Kinase	DNAJC3	ACVR1	0.854690036	5.79E-36
THYM	TF	DNAJC3	ZNF33A	0.800759171	1.76E-28
THYM	TF	DNAJC3	ZNF33B	0.8039378	7.43E-29
THYM	TF	DNAJC3	ELK3	0.810266885	1.27E-29
THYM	TF	DNAJC3	CREB3L2	0.812771045	6.20E-30
THYM	TF	DNAJC3	NFAT5	0.813790719	4.62E-30
THYM	TSG	DNAJC3	KDM3B	0.804476168	6.41E-29
THYM	TSG	DNAJC3	ARHGEF12	0.807774551	2.57E-29
THYM	TSG	DNAJC3	RNF111	0.810900632	1.06E-29
THYM	TSG	DNAJC3	ZMYND11	0.814804958	3.44E-30
THYM	TSG	DNAJC3	SASH1	0.820120161	7.09E-31
THYM	TSG	DNAJC3	PRKAR1A	0.823487006	2.54E-31
THYM	TSG	DNAJC3	ITGB1	0.825950148	1.18E-31
THYM	TSG	DNAJC3	DNAJB4	0.829988389	3.28E-32
THYM	TSG	DNAJC3	LATS2	0.83817112	2.20E-33
UCS	Cell metabolism gene	DNAJC3	SEC31A	0.800559028	1.86E-28
UCS	Cell metabolism gene	DNAJC3	SEC24D	0.805418442	4.95E-29
UCS	Cell metabolism gene	DNAJC3	PGM3	0.805515981	4.81E-29
UCS	Cell metabolism gene	DNAJC3	PIGK	0.808044862	2.38E-29
UCS	Cell metabolism gene	DNAJC3	GALNT3	0.810535277	1.18E-29
UCS	Cell metabolism gene	DNAJC3	ARSB	0.811848929	8.09E-30
UCS	Cell metabolism gene	DNAJC3	SGMS2	0.812766862	6.21E-30
UCS	Cell metabolism gene	DNAJC3	LMAN1	0.821817896	4.24E-31
UCS	Cell metabolism gene	DNAJC3	SLC16A4	0.822229086	3.74E-31
UCS	Cell metabolism gene	DNAJC3	PRKAR1A	0.823487006	2.54E-31
UCS	Cell metabolism gene	DNAJC3	PIK3C2A	0.82701258	8.47E-32
UCS	Cell metabolism gene	DNAJC3	GFPT1	0.835406379	5.58E-33
UCS	Cell metabolism gene	DNAJC3	MCFD2	0.881951577	5.19E-41
UCS	Cell metabolism gene	DNAJC3	CANX	0.902699486	9.00E-46
UCS	CGC	DNAJC3	AFF4	0.80205144	1.24E-28
UCS	CGC	DNAJC3	ARHGEF12	0.807774551	2.57E-29
UCS	CGC	DNAJC3	CREB3L2	0.812771045	6.20E-30
UCS	CGC	DNAJC3	PRKAR1A	0.823487006	2.54E-31
UCS	CGC	DNAJC3	LATS2	0.83817112	2.20E-33
UCS	CGC	DNAJC3	ACVR1	0.854690036	5.79E-36
UCS	Epifactor	DNAJC3	KDM3B	0.804476168	6.41E-29
UCS	Epifactor	DNAJC3	ZMYND11	0.814804958	3.44E-30
UCS	Epifactor	DNAJC3	BMI1	0.854831527	5.48E-36
UCS	IUPHAR	DNAJC3	PREPL	0.801858055	1.31E-28
UCS	IUPHAR	DNAJC3	KDM3B	0.804476168	6.41E-29
UCS	IUPHAR	DNAJC3	SGMS2	0.812766862	6.21E-30
UCS	IUPHAR	DNAJC3	ZMYND11	0.814804958	3.44E-30
UCS	IUPHAR	DNAJC3	SLC35F5	0.820417184	6.48E-31
UCS	IUPHAR	DNAJC3	SLC16A4	0.822229086	3.74E-31
UCS	IUPHAR	DNAJC3	CPD	0.823418598	2.59E-31
UCS	IUPHAR	DNAJC3	PRKAR1A	0.823487006	2.54E-31
UCS	IUPHAR	DNAJC3	ITGB1	0.825950148	1.18E-31
UCS	IUPHAR	DNAJC3	PIK3C2A	0.82701258	8.47E-32
UCS	IUPHAR	DNAJC3	SLC35A5	0.828556138	5.19E-32
UCS	IUPHAR	DNAJC3	ATP2A2	0.832948871	1.26E-32
UCS	IUPHAR	DNAJC3	LATS2	0.83817112	2.20E-33
UCS	IUPHAR	DNAJC3	ACVR1	0.854690036	5.79E-36
UCS	Kinase	DNAJC3	LATS2	0.83817112	2.20E-33
UCS	Kinase	DNAJC3	ACVR1	0.854690036	5.79E-36
UCS	TF	DNAJC3	ZNF33A	0.800759171	1.76E-28
UCS	TF	DNAJC3	ZNF33B	0.8039378	7.43E-29
UCS	TF	DNAJC3	ELK3	0.810266885	1.27E-29
UCS	TF	DNAJC3	CREB3L2	0.812771045	6.20E-30
UCS	TF	DNAJC3	NFAT5	0.813790719	4.62E-30
UCS	TSG	DNAJC3	KDM3B	0.804476168	6.41E-29
UCS	TSG	DNAJC3	ARHGEF12	0.807774551	2.57E-29
UCS	TSG	DNAJC3	RNF111	0.810900632	1.06E-29
UCS	TSG	DNAJC3	ZMYND11	0.814804958	3.44E-30
UCS	TSG	DNAJC3	SASH1	0.820120161	7.09E-31
UCS	TSG	DNAJC3	PRKAR1A	0.823487006	2.54E-31
UCS	TSG	DNAJC3	ITGB1	0.825950148	1.18E-31
UCS	TSG	DNAJC3	DNAJB4	0.829988389	3.28E-32
UCS	TSG	DNAJC3	LATS2	0.83817112	2.20E-33
UVM	Cell metabolism gene	DNAJC3	PDHX	0.807857187	1.36E-19
UVM	Cell metabolism gene	DNAJC3	RPE	0.821417859	1.04E-20
UVM	Cell metabolism gene	DNAJC3	MUT	0.825227668	4.82E-21
UVM	Cell metabolism gene	DNAJC3	IQGAP1	0.856714892	3.91E-24
UVM	Cell metabolism gene	DNAJC3	LMAN1	0.925431447	1.30E-34
UVM	CGC	DNAJC3	PTPN11	0.816389681	2.76E-20
UVM	Epifactor	DNAJC3	ELP2	0.833927868	7.84E-22
UVM	Epifactor	DNAJC3	CUL1	0.844132119	8.12E-23
UVM	IUPHAR	DNAJC3	ABCB7	0.873285955	4.50E-26
UVM	IUPHAR	DNAJC3	TPP2	0.879937045	6.27E-27
UVM	TSG	DNAJC3	PTPN11	0.816389681	2.76E-20
UVM	TSG	DNAJC3	CUL1	0.844132119	8.12E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	DNAJC3	PDIA6	1.39688850720027	0.000112780019881286
STAD	DNAJC3	DNAJB11	-2.58831701470337	0.000234263017773628
KIRC	DNAJC3	HSPA5	-3.68015869033778	0.000438553382338663
LIHC	DNAJC3	HSPA5	1.27259674363008	0.00268062725366399
STAD	DNAJC3	EIF2AK2	1.17314276574861	0.00315681146457791
CHOL	DNAJC3	EIF2AK2	-2.82494960203243	0.00390625
CHOL	DNAJC3	XBP1	-8.46435000705812	0.00390625
ESCA	DNAJC3	EIF2AK2	2.65103482467344	0.0048828125
STAD	DNAJC3	PDIA4	-6.44414312558725	0.00535922078415752
KIRP	DNAJC3	HSP90B1	-1.86446228658617	0.00571200484409928
KIRC	DNAJC3	DNAJB1	1.2859710297023	0.00724874285490747
STAD	DNAJC3	HSP90B1	-1.8082487306655	0.00879816571250558
STAD	DNAJC3	PDIA6	-1.83562823576885	0.0093395933508873
ESCA	DNAJC3	DNAJB11	-2.42597717048139	0.009765625
PRAD	DNAJC3	PDIA6	-2.22905717720812	0.0181156944913508
ESCA	DNAJC3	PDIA4	-2.30782881282269	0.0185546875
KICH	DNAJC3	HYOU1	-6.27112065175314	0.0187447071075439
LIHC	DNAJC3	DNAJB1	1.79689276164668	0.0227162265784831
UCEC	DNAJC3	HSP90B1	3.03409481341214	0.03125
CHOL	DNAJC3	PDIA4	-1.79788142185653	0.0390625
KICH	DNAJC3	PDIA6	2.42640579434682	1.19209289550781e-07
BRCA	DNAJC3	PDIA6	-2.61161802713444	1.45084595757064e-13
HNSC	DNAJC3	HSP90B1	-5.45363358515443	1.50112100527622e-09
KIRC	DNAJC3	DNAJB11	-1.06585882281002	2.47012955490964e-07
BRCA	DNAJC3	HYOU1	-2.40714335808139	2.58424136697134e-15
PRAD	DNAJC3	HYOU1	2.01662228702778	3.31798643818129e-07
BLCA	DNAJC3	HYOU1	-7.24240468577256	3.814697265625e-06
THCA	DNAJC3	HSPA5	-1.55933785840001	4.20046426016336e-09
KIRC	DNAJC3	PDIA4	-2.62286741965829	4.53899662243056e-11
BRCA	DNAJC3	DNAJB11	-2.21825553900809	5.6518439039327e-21
BRCA	DNAJC3	PDIA4	-2.543660823478	6.78869999729393e-28
KIRP	DNAJC3	PDIA4	-2.93284352224988	6.79492950439454e-06
THCA	DNAJC3	PDIA6	-2.19174581461745	6.92798300625088e-08
PRAD	DNAJC3	HSP90B1	1.64095926809255	7.30697930150048e-05
STAD	DNAJC3	HSPA5	-4.04539392522087	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DNAJC3

EIF2AK3, EIF2AK2, HSPA8, HSPA4, PRKRIR, DNAJB1, env, CLEC18A, GRPEL1, HSPA9, HSPH1, P4HB, PDIA6, HSPA14, HYOU1, TCTN3, TCTN1, HSPA5, TRIM25, HNRNPL, PTPRO, LAMP1, LMBR1L, TRIM28, PLEKHA4, RABL6, CASQ2, SCN4A, ORF8, E, nsp4, ORF3a, ORF7a, INS, DNAJA2, DNAJA4, DNAJB11, DNAJB12, DNAJB5, DNAJB6, DNAJC16, DNAJC1, HSPA1L, PON2, DNAJC7, TUBB4A, TMEM231, BCAP31, CNPY2, PRDX4, SEC61B, ERP29, CKAP4, SEC63, PARK7, IKBIP, KDELC2, TMTC3, DDOST, TOR1A, STT3B, EMC1, CLCC1, GANAB, NUP210, PLD3, SDF2L1, TOR1AIP1, NOMO2, PDIA3, GSR, GUSB, ERO1L, MIA3, LAMC1, LMAN1, LRPAP1, NUCB2, P4HA1, ACP1, PLOD1, PLOD2, DNAJC10, PPIB, UGGT2, PRKCSH, EMC7, UGGT1, GRAMD1A, RCN1, FKBP10, ERAP2, P3H1, HSP90B1, MOGS, TTC13, COLGALT1, CALR, CALU, TMX1, CANX, MAGT1, PLOD3, PDIA4, EMC2, MLEC, IMPDH2, FKBP8, RPN1, TXNDC5, OGT, AKAP1, CALR3, LRRC59, SYNE3, VAPA, HTRA4, SMAD4, EDEM1, SIAE, TENM3, OLFML2B, GLB1L2, WNT7A, DEDD, B4GALT4, MGAT5, TCN2, DNAJB9, GPR98, WNT10A, PYGM, PCK1, EPHA7, BRICD5, MFAP4, WNT3A, PCDHB7, ARSA, IL12RB1, SFTPC, FUT8, PCDHB3, FCN3, PRSS50, ECEL1, WNT10B, TRGV3, CDHR4, GGH, HLA-DRB3, IDS, ZFYVE1, ANPEP, CTSS, DPP4, CLEC4E, ORF10, TMEM106B,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DNAJC3	chr13	96329569	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96329587	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96361471	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DNAJC3	chr13	96361560	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96375599	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96409960	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96412327	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Malignant_tumor_of_prostate\|Ataxia,_combined_cerebellar_and_peripheral,_with_hearing_loss_and_diabetes_mellitus	SO:0001587\|nonsense	SO:0001587\|nonsense
DNAJC3	chr13	96413012	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DNAJC3	chr13	96413062	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DNAJC3	chr13	96416168	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96416192	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DNAJC3	chr13	96438294	C	T	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Ataxia,_combined_cerebellar_and_peripheral,_with_hearing_loss_and_diabetes_mellitus\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
DNAJC3	chr13	96439254	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DNAJC3	chr13	96439294	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DNAJC3	chr13	96439295	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
DNAJC3	chr13	96439340	GAAGAA	G	Microsatellite	Likely_pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
DNAJC3	chr13	96443146	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DNAJC3	ESCA	chr13	96409994	96409994	G	A	Missense_Mutation	p.A164T	3
DNAJC3	BRCA	chr13	96438207	96438207	G	A	Missense_Mutation	p.E364K	3
DNAJC3	LUAD	chr13	96416145	96416145	A	G	Missense_Mutation	p.D338G	3
DNAJC3	BLCA	chr13	96439348	96439348	G	T	Missense_Mutation	p.K432N	3
DNAJC3	SKCM	chr13	96361519	96361519	C	T	Missense_Mutation	p.L41F	3
DNAJC3	PAAD	chr13	96443261	96443261	A	G	Missense_Mutation	p.R498G	3
DNAJC3	PAAD	chr13	96409944	96409944	A	C	Missense_Mutation	p.Q147P	3
DNAJC3	BRCA	chr13	96395018	96395018	C	G	Missense_Mutation	p.P175R	3
DNAJC3	UCEC	chr13	96416094	96416094	A	G	Missense_Mutation	p.K321R	2
DNAJC3	LIHC	chr13	96412322	96412322	A	-	Frame_Shift_Del	p.E192fs	2
DNAJC3	STAD	chr13	96361576	96361576	T	C	Missense_Mutation	p.F60L	2
DNAJC3	ESCA	chr13	96409994	96409994	G	A	Missense_Mutation		2
DNAJC3	UCEC	chr13	96416198	96416198	T	C	Missense_Mutation	p.Y356H	2
DNAJC3	BLCA	chr13	96361561	96361561	G	A	Missense_Mutation	p.D55N	2
DNAJC3	CESC	chr13	96439260	96439260	G	C	Splice_Site		2
DNAJC3	LIHC	chr13	96377498	96377498	A	-	Frame_Shift_Del	p.K130fs	2
DNAJC3	STAD	chr13	96416105	96416105	G	A	Missense_Mutation	p.A325T	2
DNAJC3	UCEC	chr13	96438301	96438301	A	G	Missense_Mutation	p.Y395C	2
DNAJC3	BLCA	chr13	96409943	96409943	C	T	Nonsense_Mutation	p.Q147*	2
DNAJC3	CESC	chr13	96438251	96438251	A	C	Missense_Mutation		2
DNAJC3	PAAD	chr13	96409944	96409944	A	C	Missense_Mutation		2
DNAJC3	UCEC	chr13	96439344	96439344	A	G	Missense_Mutation	p.E431G	2
DNAJC3	CESC	chr13	96438258	96438258	G	C	Missense_Mutation		2
DNAJC3	SKCM	chr13	96415967	96415967	C	T	Missense_Mutation	p.R307C	2
DNAJC3	PAAD	chr13	96443261	96443261	A	G	Missense_Mutation		2
DNAJC3	SKCM	chr13	96329538	96329538	G	A	Missense_Mutation	p.R10Q	2
DNAJC3	UCEC	chr13	96375600	96375600	T	C	Silent	p.L100	2
DNAJC3	LIHC	chr13	96409903	96409903	A	G	Silent		2
DNAJC3	UCEC	chr13	96394968	96394968	G	T	Missense_Mutation	p.M158I	2
DNAJC3	HNSC	chr13	96416196	96416196	T	G	Missense_Mutation	p.M355R	2
DNAJC3	UCEC	chr13	96409925	96409925	G	T	Nonsense_Mutation	p.E141*	2
DNAJC3	BRCA	chr13	96412387	96412387	G	A	Missense_Mutation	p.A214T	2
DNAJC3	LUAD	chr13	96443247	96443247	C	T	Missense_Mutation	p.S493L	2
DNAJC3	STAD	chr13	96375503	96375503	C	T	Silent	p.D67D	2
DNAJC3	UCEC	chr13	96412462	96412462	G	A	Missense_Mutation	p.E239K	2
DNAJC3	KIRC	chr13	96438228	96438228	G	A	Missense_Mutation	p.E371K	2
DNAJC3	BRCA	chr13	96443192	96443192	G	A	Missense_Mutation	p.G475S	2
DNAJC3	LIHC	chr13	96409903	96409903	A	G	Silent	p.K133K	2
DNAJC3	STAD	chr13	96375615	96375615	A	G	Missense_Mutation	p.T105A	2
DNAJC3	UCEC	chr13	96412463	96412463	A	G	Missense_Mutation	p.E239G	2
DNAJC3	LUAD	chr13	96416134	96416134	G	C	Missense_Mutation	p.Q334H	1
DNAJC3	STAD	chr13	96443251	96443251	C	T	Silent	p.G494G	1
DNAJC3	BLCA	chr13	96409922	96409922	G	A	Missense_Mutation		1
DNAJC3	KIRC	chr13	96412354	96412354	G	A	Missense_Mutation	p.E203K	1
DNAJC3	SARC	chr13	96409969	96409969	G	T	Missense_Mutation		1
DNAJC3	LUAD	chr13	96415922	96415922	G	A	Missense_Mutation	p.E292K	1
DNAJC3	KIRC	chr13	96361587	96361587	C	A	Silent	p.A63A	1
DNAJC3	SARC	chr13	96443190	96443190	G	T	Missense_Mutation		1
DNAJC3	HNSC	chr13	96329505	96329505	C	T	Missense_Mutation		1
DNAJC3	LGG	chr13	96439386	96439386	C	T	Missense_Mutation	p.A445V	1
DNAJC3	LIHC	chr13	96409996	96409996	T	-	Frame_Shift_Del	p.A164fs	1
DNAJC3	SARC	chr13	96409969	96409969	G	T	Missense_Mutation	p.Q155H	1
DNAJC3	THCA	chr13	96439369	96439369	C	T	Silent		1
DNAJC3	HNSC	chr13	96416176	96416176	G	A	Silent		1
DNAJC3	OV	chr13	96395151	96395151	T	A	Missense_Mutation	p.S219R	1
DNAJC3	LGG	chr13	96377474	96377474	C	T	Missense_Mutation	p.L121F	1
DNAJC3	LIHC	chr13	96439349	96439349	A	-	Frame_Shift_Del	p.K434fs	1
DNAJC3	THCA	chr13	96439369	96439369	C	T	Silent	p.F439F	1
DNAJC3	HNSC	chr13	96416196	96416196	T	G	Missense_Mutation		1
DNAJC3	BLCA	chr13	96361567	96361567	T	G	Missense_Mutation	p.L57V	1
DNAJC3	LGG	chr13	96439386	96439386	C	T	Missense_Mutation		1
DNAJC3	CESC	chr13	96439260	96439260	G	C	Splice_Site	e11-1	1
DNAJC3	LIHC	chr13	96438208	96438208	A	-	Frame_Shift_Del	p.E364fs	1
DNAJC3	THYM	chr13	96415992	96415992	G	T	Missense_Mutation	p.C315F	1
DNAJC3	HNSC	chr13	96375576	96375576	C	T	Missense_Mutation		1
DNAJC3	BLCA	chr13	96416174	96416174	G	C	Missense_Mutation	p.E348Q	1
DNAJC3	LIHC	chr13	96412965	96412965	A	G	Missense_Mutation		1
DNAJC3	CESC	chr13	96438251	96438251	A	C	Missense_Mutation	p.E378D	1
DNAJC3	LIHC	chr13	96443200	96443200	T	-	Frame_Shift_Del	p.P477fs	1
DNAJC3	BLCA	chr13	96361561	96361561	G	A	Missense_Mutation		1
DNAJC3	HNSC	chr13	96375576	96375576	C	T	Missense_Mutation	p.P92S	1
DNAJC3	BLCA	chr13	96375563	96375563	A	T	Silent	p.S87S	1
DNAJC3	CESC	chr13	96438258	96438258	G	C	Missense_Mutation	p.E381Q	1
DNAJC3	LIHC	chr13	96415972	96415972	A	-	Frame_Shift_Del	p.S308fs	1
DNAJC3	SKCM	chr13	96412327	96412327	C	T	Nonsense_Mutation	p.R194*	1
DNAJC3	BLCA	chr13	96439348	96439348	G	T	Missense_Mutation		1
DNAJC3	BLCA	chr13	96438198	96438198	C	T	Nonsense_Mutation	p.Q361*	1
DNAJC3	LIHC	chr13	96377449	96377449	T	C	Silent		1
DNAJC3	PRAD	chr13	96443194	96443194	C	T	Silent	p.G475G	1
DNAJC3	CHOL	chr13	96412357	96412357	C	A	Missense_Mutation	p.P204T	1
DNAJC3	LUAD	chr13	96438214	96438214	C	T	Missense_Mutation	p.A366V	1
DNAJC3	SKCM	chr13	96443190	96443190	G	A	Missense_Mutation	p.G474D	1
DNAJC3	BLCA	chr13	96361567	96361567	T	G	Missense_Mutation		1
DNAJC3	HNSC	chr13	96416176	96416176	G	A	Silent	p.E348E	1
DNAJC3	LIHC	chr13	96410006	96410006	G	A	Missense_Mutation		1
DNAJC3	READ	chr13	96412433	96412433	G	A	Missense_Mutation	p.S229N	1
DNAJC3	COAD	chr13	96410006	96410006	G	A	Missense_Mutation	p.G168R	1
DNAJC3	BLCA	chr13	96361493	96361493	G	T	Missense_Mutation		1
DNAJC3	SARC	chr13	96412384	96412384	G	T	Missense_Mutation		1
DNAJC3	COAD	chr13	96443252	96443252	G	A	Missense_Mutation	p.G495R	1
DNAJC3	LUAD	chr13	96439306	96439306	A	T	Silent	p.A418A	1
DNAJC3	BLCA	chr13	96416174	96416174	G	C	Missense_Mutation		1
DNAJC3	KIRC	chr13	96361504	96361504	G	A	Missense_Mutation	p.D36N	1
DNAJC3	LIHC	chr13	96412419	96412420	-	T	Frame_Shift_Ins	p.L225fs	1
DNAJC3	SARC	chr13	96375504	96375504	C	A	Missense_Mutation		1

Copy number variation (CNV) of DNAJC3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DNAJC3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99324	N/A	FN086178	AIM2	chr1	159071767	+	DNAJC3	chr13	96446744	+
99324	N/A	BF996610	AKT2	chr19	40771152	-	DNAJC3	chr13	96445542	-
99324	N/A	EI788237	BTBD11	chr12	107928357	-	DNAJC3	chr13	96384676	+
99324	N/A	AA508569	C1S	chr12	7178336	+	DNAJC3	chr13	96362506	-
99324	N/A	U28424	CELF1	chr11	47488801	+	DNAJC3	chr13	96329483	+
100026	OV	TCGA-04-1514	DNAJC3	chr13	96361591	+	BAZ1B	chr7	72884813	-
96165	N/A	AF339816	DNAJC3	chr13	96445737	-	BID	chr22	18228626	+
103069	N/A	BG992563	DNAJC3	chr13	96444658	-	CBFA2T2	chr20	32110101	+
102117	N/A	EI781735	DNAJC3	chr13	96336145	-	CKAP5	chr11	46865998	-
87291	GBM	TCGA-14-0787-01A	DNAJC3	chr13	96416207	+	CLDN10	chr13	96212386	+
87291	LUAD	TCGA-44-4112-01A	DNAJC3	chr13	96329591	+	CLDN10	chr13	96212386	+
99324	N/A	AA533636	DNAJC3	chr13	96445339	+	DNAJC3	chr13	96445492	-
99324	N/A	AV747684	DNAJC3	chr13	96445108	+	DNAJC3	chr13	96377448	+
98200	N/A	BF327158	DNAJC3	chr13	96421588	+	FAM222B	chr17	27103906	-
94452	HNSC	TCGA-CV-7438	DNAJC3	chr13	96377506	+	FOXN3	chr14	89817152	-
98325	BRCA	TCGA-GM-A2DF-01A	DNAJC3	chr13	96329591	-	GPC6	chr13	94679983	+
98325	STAD	TCGA-HU-A4GH-01A	DNAJC3	chr13	96329591	+	GPC6	chr13	94482407	+
95580	N/A	AX341659	DNAJC3	chr13	96407545	-	HSD17B4	chr5	118877949	-
96788	LIHC	TCGA-DD-A1EJ-01A	DNAJC3	chr13	96329591	+	MCF2L	chr13	113678958	+
79503	N/A	BE004606	DNAJC3	chr13	96444701	-	NPC2	chr14	74946734	+
95067	STAD	TCGA-HF-A5NB	DNAJC3	chr13	96377506	+	STK24	chr13	99118815	-
87800	N/A	AY957067	DNAJC3	chr13	96348597	+	STK32B	chr4	5406416	+
89570	N/A	BI496356	DNAJC3	chr13	96385991	+	XPNPEP1	chr10	111624525	+
99324	SARC	TCGA-DX-AB2P-01A	PCCA	chr13	100888132	+	DNAJC3	chr13	96443127	+
99324	PRAD	TCGA-H9-7775-01A	RAF1	chr3	12644582	-	DNAJC3	chr13	96416206	-
99341	N/A	DA727905	WNK1	chr12	994550	+	DNAJC3	chr13	96361511	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	DNAJC3	0.00427117152639423	0.12
SARC	DNAJC3	0.0327525639641725	0.88
READ	DNAJC3	0.0361831605806665	0.94

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	DNAJC3	0.00150135443356335	0.048
PRAD	DNAJC3	0.0104453918991844	0.32
CESC	DNAJC3	0.0250091195786174	0.75
ESCA	DNAJC3	0.00055854896811666	0.018
THYM	DNAJC3	0.0398326192447414	1
COAD	DNAJC3	0.0468991673570424	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0376358	Malignant neoplasm of prostate	1	CTD_human
C4015436	ATAXIA, COMBINED CEREBELLAR AND PERIPHERAL, WITH HEARING LOSS AND DIABETES MELLITUS	1	CTD_human;GENOMICS_ENGLAND;ORPHANET