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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TNRC6C (NCBI Gene ID:57690)

Gene Summary

Gene Summary

Gene Information	Gene Name: TNRC6C
	Gene ID: 57690
	Gene Symbol	TNRC6C
	Gene ID	57690
	Gene Name	trinucleotide repeat containing adaptor 6C
	Synonyms	-
	Cytomap	17q25.3
	Type of Gene	protein-coding
	Description	trinucleotide repeat-containing gene 6C proteintrinucleotide repeat containing 6C
	Modification date	20200313
	UniProtAcc	Q9HCJ0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNRC6C	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21984185
Hgene	TNRC6C	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21984185

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TNRC6C	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'TNRC6C[title] AND translation [title] AND human.'

Gene	Title	PMID
TNRC6C	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000588061	76008083	76008141	5UTR-5UTR
ENST00000301624	76027596	76027923	5UTR-5UTR
ENST00000301624	76067165	76067246	In-frame
ENST00000588061	76067165	76067246	In-frame
ENST00000301624	76073265	76073415	In-frame
ENST00000588061	76073265	76073415	In-frame
ENST00000301624	76075475	76075622	In-frame
ENST00000588061	76075475	76075622	In-frame
ENST00000301624	76079127	76079247	In-frame
ENST00000588061	76079127	76079247	In-frame
ENST00000301624	76087520	76087688	In-frame
ENST00000588061	76087520	76087688	In-frame
ENST00000301624	76089013	76089205	In-frame
ENST00000588061	76089013	76089205	In-frame
ENST00000301624	76094423	76094618	In-frame
ENST00000588061	76094423	76094618	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000588061	76067165	76067246	8436	3506	3586	1690	926	953
ENST00000301624	76067165	76067246	9649	3348	3428	1690	926	953
ENST00000588061	76073265	76073415	8436	3788	3937	1690	1020	1070
ENST00000301624	76073265	76073415	9649	3630	3779	1690	1020	1070
ENST00000588061	76075475	76075622	8436	3938	4084	1690	1070	1119
ENST00000301624	76075475	76075622	9649	3780	3926	1690	1070	1119
ENST00000588061	76079127	76079247	8436	4085	4204	1690	1119	1159
ENST00000301624	76079127	76079247	9649	3927	4046	1690	1119	1159
ENST00000588061	76087520	76087688	8436	4530	4697	1690	1267	1323
ENST00000301624	76087520	76087688	9649	4372	4539	1690	1267	1323
ENST00000588061	76089013	76089205	8436	4698	4889	1690	1323	1387
ENST00000301624	76089013	76089205	9649	4540	4731	1690	1323	1387
ENST00000588061	76094423	76094618	8436	5034	5228	1690	1435	1500
ENST00000301624	76094423	76094618	9649	4876	5070	1690	1435	1500

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9HCJ0	1020	1070	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	926	953	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1070	1119	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1119	1159	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1267	1323	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1435	1500	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1323	1387	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1020	1070	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	926	953	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1070	1119	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1119	1159	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1267	1323	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1435	1500	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	1323	1387	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
Q9HCJ0	926	953	933	978	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00212
Q9HCJ0	926	953	933	978	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00212
Q9HCJ0	926	953	1	926	Region	Note=Sufficient for interaction with argonaute family proteins
Q9HCJ0	926	953	1	926	Region	Note=Sufficient for interaction with argonaute family proteins
Q9HCJ0	1267	1323	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21981923;Dbxref=PMID:21981923
Q9HCJ0	1435	1500	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21981923;Dbxref=PMID:21981923
Q9HCJ0	1323	1387	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21981923;Dbxref=PMID:21981923
Q9HCJ0	1267	1323	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21981923;Dbxref=PMID:21981923
Q9HCJ0	1435	1500	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21981923;Dbxref=PMID:21981923
Q9HCJ0	1323	1387	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21981923;Dbxref=PMID:21981923
Q9HCJ0	1435	1500	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
Q9HCJ0	1323	1387	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
Q9HCJ0	1435	1500	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
Q9HCJ0	1323	1387	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
Q9HCJ0	1323	1387	1371	1417	Region	Note=Required for interaction with PABPC1
Q9HCJ0	1323	1387	1371	1417	Region	Note=Required for interaction with PABPC1
Q9HCJ0	1323	1387	1381	1399	Region	Note=PABPC1-interacting motif-2 (PAM2)
Q9HCJ0	1323	1387	1381	1399	Region	Note=PABPC1-interacting motif-2 (PAM2)
Q9HCJ0	1119	1159	1156	1214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9HCJ0	1119	1159	1156	1214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9HCJ0	1435	1500	1435	1435	Alternative sequence	ID=VSP_023322;Note=In isoform 2. G->GGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
Q9HCJ0	1435	1500	1435	1435	Alternative sequence	ID=VSP_023322;Note=In isoform 2. G->GGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
Q9HCJ0	1267	1323	1294	1300	Mutagenesis	Note=Abolishes association with CCR4-NOT complex. QSRLPQW->AAAAPAA
Q9HCJ0	1267	1323	1294	1300	Mutagenesis	Note=Abolishes association with CCR4-NOT complex. QSRLPQW->AAAAPAA
Q9HCJ0	1435	1500	1445	1445	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1487%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21984184;Dbxref=PMID:21984184
Q9HCJ0	1435	1500	1445	1445	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1487%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21984184;Dbxref=PMID:21984184
Q9HCJ0	1435	1500	1487	1487	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21984184;Dbxref=PMID:21984184
Q9HCJ0	1435	1500	1487	1487	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21984184;Dbxref=PMID:21984184
Q9HCJ0	1435	1500	1494	1494	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1487%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21984184;Dbxref=PMID:21984184
Q9HCJ0	1435	1500	1494	1494	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1487%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21984184;Dbxref=PMID:21984184
Q9HCJ0	926	953	936	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DKL
Q9HCJ0	926	953	936	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DKL

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	TNRC6C	1.3512001263532	7.52485613123653e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	TNRC6C	-0.2359711	0.023782089

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TNRC6C (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	CGC	TNRC6C	NUMA1	0.802421904	5.83E-40
GBM	CGC	TNRC6C	SPEN	0.816079539	2.47E-42
GBM	CGC	TNRC6C	MLLT6	0.81915621	6.78E-43
GBM	Epifactor	TNRC6C	BPTF	0.810948393	2.03E-41
GBM	Epifactor	TNRC6C	SPEN	0.816079539	2.47E-42
GBM	Epifactor	TNRC6C	MLLT6	0.81915621	6.78E-43
GBM	IUPHAR	TNRC6C	BPTF	0.810948393	2.03E-41
GBM	TF	TNRC6C	ZNF142	0.806360661	1.26E-40
GBM	TF	TNRC6C	BPTF	0.810948393	2.03E-41
GBM	TF	TNRC6C	SPEN	0.816079539	2.47E-42
THYM	Cell metabolism gene	TNRC6C	GNG2	0.808476656	2.11E-29
THYM	Cell metabolism gene	TNRC6C	DGKA	0.812688574	6.35E-30
THYM	Cell metabolism gene	TNRC6C	SLC23A1	0.812770568	6.20E-30
THYM	Cell metabolism gene	TNRC6C	DGKE	0.822665108	3.27E-31
THYM	Cell metabolism gene	TNRC6C	PAFAH2	0.844662732	2.32E-34
THYM	Cell metabolism gene	TNRC6C	SMPD3	0.859332615	9.53E-37
THYM	Cell metabolism gene	TNRC6C	ELOVL4	0.866543392	5.07E-38
THYM	CGC	TNRC6C	RHOH	0.807155832	3.05E-29
THYM	CGC	TNRC6C	CBFA2T3	0.812743199	6.25E-30
THYM	CGC	TNRC6C	LCK	0.813694527	4.75E-30
THYM	CGC	TNRC6C	CCND3	0.823256487	2.73E-31
THYM	CGC	TNRC6C	MYB	0.824468295	1.88E-31
THYM	CGC	TNRC6C	LEF1	0.832504611	1.45E-32
THYM	Epifactor	TNRC6C	GFI1	0.800238615	2.03E-28
THYM	Epifactor	TNRC6C	MTA3	0.818702913	1.09E-30
THYM	Epifactor	TNRC6C	RAG2	0.825736484	1.26E-31
THYM	Epifactor	TNRC6C	HDAC7	0.835556019	5.31E-33
THYM	IUPHAR	TNRC6C	SLC7A6	0.80049527	1.89E-28
THYM	IUPHAR	TNRC6C	CD1D	0.80316346	9.19E-29
THYM	IUPHAR	TNRC6C	ZAP70	0.808870955	1.89E-29
THYM	IUPHAR	TNRC6C	CYP2U1	0.810841605	1.08E-29
THYM	IUPHAR	TNRC6C	CAMK4	0.811840173	8.11E-30
THYM	IUPHAR	TNRC6C	CD247	0.812053126	7.63E-30
THYM	IUPHAR	TNRC6C	SLC23A1	0.812770568	6.20E-30
THYM	IUPHAR	TNRC6C	LCK	0.813694527	4.75E-30
THYM	IUPHAR	TNRC6C	CD3E	0.815594871	2.73E-30
THYM	IUPHAR	TNRC6C	PVRIG	0.820932286	5.55E-31
THYM	IUPHAR	TNRC6C	KCNJ4	0.823687909	2.39E-31
THYM	IUPHAR	TNRC6C	SLC7A3	0.828945583	4.59E-32
THYM	IUPHAR	TNRC6C	CD4	0.830956667	2.40E-32
THYM	IUPHAR	TNRC6C	HDAC7	0.835556019	5.31E-33
THYM	IUPHAR	TNRC6C	CCR9	0.837939338	2.38E-33
THYM	IUPHAR	TNRC6C	RORC	0.839852566	1.24E-33
THYM	IUPHAR	TNRC6C	PAFAH2	0.844662732	2.32E-34
THYM	IUPHAR	TNRC6C	ATP8B3	0.844675675	2.31E-34
THYM	IUPHAR	TNRC6C	CHRNA3	0.845580644	1.67E-34
THYM	IUPHAR	TNRC6C	LAIR1	0.851747267	1.76E-35
THYM	IUPHAR	TNRC6C	SMPD3	0.859332615	9.53E-37
THYM	IUPHAR	TNRC6C	STK32B	0.869530193	1.43E-38
THYM	IUPHAR	TNRC6C	PRKCG	0.872222317	4.45E-39
THYM	Kinase	TNRC6C	ZAP70	0.808870955	1.89E-29
THYM	Kinase	TNRC6C	CAMK4	0.811840173	8.11E-30
THYM	Kinase	TNRC6C	LCK	0.813694527	4.75E-30
THYM	Kinase	TNRC6C	STK32B	0.869530193	1.43E-38
THYM	Kinase	TNRC6C	PRKCG	0.872222317	4.45E-39
THYM	TF	TNRC6C	GFI1	0.800238615	2.03E-28
THYM	TF	TNRC6C	MAFK	0.801155867	1.58E-28
THYM	TF	TNRC6C	MYB	0.824468295	1.88E-31
THYM	TF	TNRC6C	LEF1	0.832504611	1.45E-32
THYM	TF	TNRC6C	TFDP2	0.833804136	9.49E-33
THYM	TF	TNRC6C	E2F2	0.834460809	7.64E-33
THYM	TF	TNRC6C	RORC	0.839852566	1.24E-33
THYM	TF	TNRC6C	TCF7	0.840292934	1.07E-33
THYM	TF	TNRC6C	NFATC3	0.855329692	4.53E-36
THYM	TSG	TNRC6C	CBFA2T3	0.812743199	6.25E-30
THYM	TSG	TNRC6C	CD4	0.830956667	2.40E-32
THYM	TSG	TNRC6C	E2F2	0.834460809	7.64E-33
THYM	TSG	TNRC6C	MAL	0.84083049	8.87E-34
UCS	Cell metabolism gene	TNRC6C	GNG2	0.808476656	2.11E-29
UCS	Cell metabolism gene	TNRC6C	DGKA	0.812688574	6.35E-30
UCS	Cell metabolism gene	TNRC6C	SLC23A1	0.812770568	6.20E-30
UCS	Cell metabolism gene	TNRC6C	DGKE	0.822665108	3.27E-31
UCS	Cell metabolism gene	TNRC6C	PAFAH2	0.844662732	2.32E-34
UCS	Cell metabolism gene	TNRC6C	SMPD3	0.859332615	9.53E-37
UCS	Cell metabolism gene	TNRC6C	ELOVL4	0.866543392	5.07E-38
UCS	CGC	TNRC6C	RHOH	0.807155832	3.05E-29
UCS	CGC	TNRC6C	CBFA2T3	0.812743199	6.25E-30
UCS	CGC	TNRC6C	LCK	0.813694527	4.75E-30
UCS	CGC	TNRC6C	CCND3	0.823256487	2.73E-31
UCS	CGC	TNRC6C	MYB	0.824468295	1.88E-31
UCS	CGC	TNRC6C	LEF1	0.832504611	1.45E-32
UCS	Epifactor	TNRC6C	GFI1	0.800238615	2.03E-28
UCS	Epifactor	TNRC6C	MTA3	0.818702913	1.09E-30
UCS	Epifactor	TNRC6C	RAG2	0.825736484	1.26E-31
UCS	Epifactor	TNRC6C	HDAC7	0.835556019	5.31E-33
UCS	IUPHAR	TNRC6C	SLC7A6	0.80049527	1.89E-28
UCS	IUPHAR	TNRC6C	CD1D	0.80316346	9.19E-29
UCS	IUPHAR	TNRC6C	ZAP70	0.808870955	1.89E-29
UCS	IUPHAR	TNRC6C	CYP2U1	0.810841605	1.08E-29
UCS	IUPHAR	TNRC6C	CAMK4	0.811840173	8.11E-30
UCS	IUPHAR	TNRC6C	CD247	0.812053126	7.63E-30
UCS	IUPHAR	TNRC6C	SLC23A1	0.812770568	6.20E-30
UCS	IUPHAR	TNRC6C	LCK	0.813694527	4.75E-30
UCS	IUPHAR	TNRC6C	CD3E	0.815594871	2.73E-30
UCS	IUPHAR	TNRC6C	PVRIG	0.820932286	5.55E-31
UCS	IUPHAR	TNRC6C	KCNJ4	0.823687909	2.39E-31
UCS	IUPHAR	TNRC6C	SLC7A3	0.828945583	4.59E-32
UCS	IUPHAR	TNRC6C	CD4	0.830956667	2.40E-32
UCS	IUPHAR	TNRC6C	HDAC7	0.835556019	5.31E-33
UCS	IUPHAR	TNRC6C	CCR9	0.837939338	2.38E-33
UCS	IUPHAR	TNRC6C	RORC	0.839852566	1.24E-33
UCS	IUPHAR	TNRC6C	PAFAH2	0.844662732	2.32E-34
UCS	IUPHAR	TNRC6C	ATP8B3	0.844675675	2.31E-34
UCS	IUPHAR	TNRC6C	CHRNA3	0.845580644	1.67E-34
UCS	IUPHAR	TNRC6C	LAIR1	0.851747267	1.76E-35
UCS	IUPHAR	TNRC6C	SMPD3	0.859332615	9.53E-37
UCS	IUPHAR	TNRC6C	STK32B	0.869530193	1.43E-38
UCS	IUPHAR	TNRC6C	PRKCG	0.872222317	4.45E-39
UCS	Kinase	TNRC6C	ZAP70	0.808870955	1.89E-29
UCS	Kinase	TNRC6C	CAMK4	0.811840173	8.11E-30
UCS	Kinase	TNRC6C	LCK	0.813694527	4.75E-30
UCS	Kinase	TNRC6C	STK32B	0.869530193	1.43E-38
UCS	Kinase	TNRC6C	PRKCG	0.872222317	4.45E-39
UCS	TF	TNRC6C	GFI1	0.800238615	2.03E-28
UCS	TF	TNRC6C	MAFK	0.801155867	1.58E-28
UCS	TF	TNRC6C	MYB	0.824468295	1.88E-31
UCS	TF	TNRC6C	LEF1	0.832504611	1.45E-32
UCS	TF	TNRC6C	TFDP2	0.833804136	9.49E-33
UCS	TF	TNRC6C	E2F2	0.834460809	7.64E-33
UCS	TF	TNRC6C	RORC	0.839852566	1.24E-33
UCS	TF	TNRC6C	TCF7	0.840292934	1.07E-33
UCS	TF	TNRC6C	NFATC3	0.855329692	4.53E-36
UCS	TSG	TNRC6C	CBFA2T3	0.812743199	6.25E-30
UCS	TSG	TNRC6C	CD4	0.830956667	2.40E-32
UCS	TSG	TNRC6C	E2F2	0.834460809	7.64E-33
UCS	TSG	TNRC6C	MAL	0.84083049	8.87E-34

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	TNRC6C	SETD1A	2.23961225656762	0.000256400555372238
KICH	TNRC6C	MYC	1.19194684236579	0.000329077243804932
LUAD	TNRC6C	SETD1A	-1.25354485923778	0.00034760699866943
KICH	TNRC6C	SETD1A	-1.81005336469658	0.000631332397460937
COAD	TNRC6C	SETD1A	-3.09305284726853	0.000934779644012452
THCA	TNRC6C	EP300	-1.56308189039603	0.00135477973345976
LUSC	TNRC6C	MYC	1.80145319254842	0.00250329335752618
PRAD	TNRC6C	EP300	1.28001120737624	0.00383473418852013
CHOL	TNRC6C	PABPC1	-4.56272528815353	0.00390625
BLCA	TNRC6C	PABPC1	1.31485302792746	0.0180816650390625
LUSC	TNRC6C	SETD1B	-11.2328824858743	0.027282535479515
LIHC	TNRC6C	PABPC1	-1.72076961362188	2.98009622125841e-06
KIRC	TNRC6C	MYC	-7.57321539520974	3.45880777969452e-10
LUSC	TNRC6C	SETD1A	-5.79621909719209	7.61148795377e-06
PRAD	TNRC6C	PABPC1	-2.10200318363476	8.55379952759014e-07
KIRP	TNRC6C	MYC	-5.46971831522856	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TNRC6C

PABPC1, CUL3, CAND1, AGO1, AGO2, AGO3, AGO4, HNRNPUL2, PABPC4, CNOT1, CNOT10, CNOT3, CNOT8, CNOT6, PAN2, PAN3, GNB2L1, NR2E1, AURKA, CNOT2, CNOT6L, CNOT7, NAPRT, SSX2IP, CNTROB, CEP44, ODF2, SCLT1, XPO1, ATOH1, DEF6, DLST, BRCA1, HNRNPL, TOMM20, KIAA1429, PHB, BICD1, NINL, ARIH2, HCVgp1, ANKRD17, CELF1, CEP85, RQCD1, CPEB4, DCP1A, FAM120C, FUBP3, KIAA0355, MEX3B, PRRC2A, R3HDM2, RC3H1, TNRC6A, TNRC6B, AP2A1, AP2B1, AP2M1, BCAR1, C10orf88, CEP135, CEP192, CEP55, CNOT11, CYLD, DSP, DVL2, FAM184A, GIGYF1, GPBP1L1, LZTS2, MIB2, MPHOSPH9, NME7, NUPL1, SEC16A, SEC23B, SEC24A, SEC24B, SPATA2, TBK1, TBKBP1, TCHP, TFG, TNIP1, USP54, UBAP2L, UNK, YTHDF2, YTHDF3, ZC3H7A, ZFP36, CTIF, PUM1, CCDC18, GPBP1, ITSN1, ITSN2, KIAA1524, KIZ, SEC23A, SMG7, TAB1, TTK, HELZ, EIF4E2, SYNM, MKRN2, IQCC, LIMD1, RAVER1, SMAP2, TNPO2, KIF14, RHOT2, nsp12ab, UBC, CLTA, KRT8, LATS1, STIL, SYNE3, VCL, CPEB1, ETV6,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TNRC6C	chr17	76046165	G	A	single_nucleotide_variant	Uncertain_significance	Intellectual_disability	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TNRC6C	LUAD	chr17	76047196	76047196	G	A	Missense_Mutation	p.V685M	7
TNRC6C	BRCA	chr17	76083023	76083023	G	A	Silent	p.P1214	4
TNRC6C	LUAD	chr17	76060902	76060902	C	T	Missense_Mutation	p.A829V	4
TNRC6C	LUAD	chr17	76045357	76045357	G	A	Missense_Mutation	p.G72R	4
TNRC6C	UCEC	chr17	76089762	76089762	C	T	Silent	p.D1405	4
TNRC6C	LUAD	chr17	76060929	76060929	G	A	Missense_Mutation	p.G838D	4
TNRC6C	UCEC	chr17	76047222	76047222	C	T	Silent	p.I693	4
TNRC6C	HNSC	chr17	76045225	76045225	G	A	Missense_Mutation	p.V28I	3
TNRC6C	BRCA	chr17	76045634	76045634	C	T	Missense_Mutation	p.T164M	3
TNRC6C	BRCA	chr17	76046623	76046623	G	A	Missense_Mutation	p.D494N	3
TNRC6C	UCS	chr17	76045946	76045946	G	A	Missense_Mutation	p.G268E	3
TNRC6C	CESC	chr17	76046332	76046332	G	A	Missense_Mutation	p.E397K	3
TNRC6C	SKCM	chr17	76046247	76046247	C	T	Silent	p.V368V	3
TNRC6C	LUAD	chr17	76083029	76083029	G	A	Silent	p.P1216P	3
TNRC6C	KIRP	chr17	76046980	76046980	A	-	Frame_Shift_Del	p.K614fs	3
TNRC6C	LUAD	chr17	76047273	76047273	G	T	Missense_Mutation	p.W710C	3
TNRC6C	CESC	chr17	76093866	76093866	T	C	Silent		3
TNRC6C	GBM	chr17	76089149	76089149	G	A	Missense_Mutation	p.R1369H	3
TNRC6C	BLCA	chr17	76047083	76047083	C	T	Missense_Mutation	p.T647I	3
TNRC6C	LUAD	chr17	76061008	76061008	G	A	Silent	p.L864L	3
TNRC6C	UCEC	chr17	76094525	76094525	G	A	Missense_Mutation	p.A1506T	2
TNRC6C	PAAD	chr17	76089140	76089140	G	A	Missense_Mutation		2
TNRC6C	PRAD	chr17	76045218	76045218	C	T	Silent	p.G25G	2
TNRC6C	STAD	chr17	76046762	76046762	C	T	Missense_Mutation	p.S540L	2
TNRC6C	UCEC	chr17	76060930	76060930	C	T	Silent	p.G838	2
TNRC6C	TGCT	chr17	76075489	76075489	A	G	Missense_Mutation		2
TNRC6C	LIHC	chr17	76060811	76060811	G	A	Splice_Site		2
TNRC6C	CESC	chr17	76045615	76045615	G	A	Missense_Mutation	p.E158K	2
TNRC6C	HNSC	chr17	76046980	76046980	A	G	Missense_Mutation	p.K613E	2
TNRC6C	SKCM	chr17	76045235	76045235	C	T	Missense_Mutation	p.P31L	2
TNRC6C	ESCA	chr17	76047421	76047423	ACC	-	In_Frame_Del	p.T768del	2
TNRC6C	STAD	chr17	76073380	76073380	G	A	Missense_Mutation	p.G1059R	2
TNRC6C	KIRP	chr17	76045567	76045567	G	T	Missense_Mutation	p.G142W	2
TNRC6C	UCEC	chr17	76063847	76063847	C	A	Missense_Mutation	p.S871Y	2
TNRC6C	ESCA	chr17	76046827	76046827	G	T	Missense_Mutation	p.A562S	2
TNRC6C	HNSC	chr17	76089205	76089205	G	C	Splice_Site	p.E1385_splice	2
TNRC6C	LIHC	chr17	76083086	76083086	C	-	Frame_Shift_Del	p.F1235fs	2
TNRC6C	PAAD	chr17	76060855	76060855	T	C	Silent	p.S816S	2
TNRC6C	SARC	chr17	76047077	76047077	C	A	Missense_Mutation		2
TNRC6C	GBM	chr17	76082938	76082938	C	T	Missense_Mutation	p.A1189V	2
TNRC6C	STAD	chr17	76075622	76075622	G	T	Missense_Mutation	p.Q1119H	2
TNRC6C	UCEC	chr17	76063981	76063981	G	A	Missense_Mutation	p.A916T	2
TNRC6C	LIHC	chr17	76046694	76046694	G	A	Silent	p.V517V	2
TNRC6C	PAAD	chr17	76083142	76083142	C	A	Missense_Mutation	p.S1257Y	2
TNRC6C	SARC	chr17	76047369	76047369	A	G	Silent		2
TNRC6C	STAD	chr17	76089187	76089187	A	G	Missense_Mutation	p.S1382G	2
TNRC6C	UCEC	chr17	76071243	76071243	G	A	Missense_Mutation	p.V979M	2
TNRC6C	SARC	chr17	76047077	76047077	C	A	Missense_Mutation	p.T645K	2
TNRC6C	COAD	chr17	76046980	76046980	A	-	Frame_Shift_Del	p.G612fs	2
TNRC6C	ESCA	chr17	76063908	76063908	G	C	Missense_Mutation	p.E891D	2
TNRC6C	ESCA	chr17	76063908	76063908	G	C	Missense_Mutation		2
TNRC6C	PAAD	chr17	76089140	76089140	G	A	Missense_Mutation	p.S1366N	2
TNRC6C	SARC	chr17	76100679	76100679	G	T	Missense_Mutation		2
TNRC6C	CESC	chr17	76060847	76060847	G	A	Missense_Mutation		2
TNRC6C	STAD	chr17	76046871	76046871	G	T	Missense_Mutation	p.K576N	2
TNRC6C	UCEC	chr17	76079172	76079172	C	T	Silent	p.L1131	2
TNRC6C	ESCA	chr17	76099514	76099514	G	T	Missense_Mutation	p.R1567L	2
TNRC6C	LUAD	chr17	76046101	76046101	G	A	Missense_Mutation	p.V320I	2
TNRC6C	SARC	chr17	76045614	76045614	A	G	Silent		2
TNRC6C	ACC	chr17	76067213	76067213	G	C	Silent	p.R942R	2
TNRC6C	STAD	chr17	76071268	76071268	C	T	Missense_Mutation	p.T990I	2
TNRC6C	UCEC	chr17	76082939	76082939	G	A	Silent	p.A1186	2
TNRC6C	HNSC	chr17	76045219	76045219	G	A	Missense_Mutation	p.A26T	2
TNRC6C	LIHC	chr17	76045261	76045261	G	-	Frame_Shift_Del	p.G41fs	2
TNRC6C	ESCA	chr17	76100682	76100682	C	T	Missense_Mutation	p.A1646V	2
TNRC6C	STAD	chr17	76079238	76079238	G	T	Missense_Mutation		2
TNRC6C	CESC	chr17	76046915	76046915	C	G	Missense_Mutation		2
TNRC6C	UCEC	chr17	76082993	76082993	C	T	Silent	p.A1204	2
TNRC6C	HNSC	chr17	76046391	76046391	G	A	Silent	p.T416T	2
TNRC6C	LIHC	chr17	76046694	76046694	G	A	Silent		2
TNRC6C	SKCM	chr17	76046872	76046872	C	T	Missense_Mutation	p.P577S	2
TNRC6C	SKCM	chr17	76089072	76089072	C	T	Silent	p.S1340S	2
TNRC6C	STAD	chr17	76087561	76087561	G	T	Missense_Mutation	p.M1281I	2
TNRC6C	UCEC	chr17	76045538	76045538	C	A	Missense_Mutation	p.A132D	2
TNRC6C	CESC	chr17	76046332	76046332	G	A	Missense_Mutation		2
TNRC6C	UCEC	chr17	76083092	76083092	G	A	Silent	p.S1237	2
TNRC6C	COAD	chr17	76083070	76083070	C	T	Missense_Mutation	p.S1233L	2
TNRC6C	SKCM	chr17	76045900	76045900	C	T	Missense_Mutation	p.P253S	2
TNRC6C	SKCM	chr17	76098601	76098601	C	T	Silent	p.L1552L	2
TNRC6C	ESCA	chr17	76047107	76047107	G	-	Frame_Shift_Del	p.W655fs	2
TNRC6C	STAD	chr17	76045711	76045711	A	G	Missense_Mutation	p.M190V	2
TNRC6C	KICH	chr17	76071339	76071339	C	T	Missense_Mutation	p.R1014C	2
TNRC6C	UCEC	chr17	76046060	76046060	C	A	Missense_Mutation	p.P306H	2
TNRC6C	PAAD	chr17	76047129	76047153	CCCCCAACAGAACTGGGCTAGCAAA	-	Frame_Shift_Del	p.GPQQNWASK662fs	2
TNRC6C	CESC	chr17	76045615	76045615	G	A	Missense_Mutation		2
TNRC6C	BLCA	chr17	76047219	76047219	G	A	Nonsense_Mutation	p.W692*	2
TNRC6C	HNSC	chr17	76045388	76045388	G	A	Missense_Mutation	p.R82K	2
TNRC6C	PAAD	chr17	76060855	76060855	T	C	Silent		2
TNRC6C	BRCA	chr17	76047128	76047128	G	A	Missense_Mutation	p.G662D	2
TNRC6C	STAD	chr17	76047111	76047111	G	T	Silent	p.G656G	2
TNRC6C	UCEC	chr17	76046644	76046644	A	G	Missense_Mutation	p.T501A	2
TNRC6C	PAAD	chr17	76046827	76046827	G	A	Missense_Mutation	p.A562T	2
TNRC6C	CESC	chr17	76067246	76067246	G	A	Silent		2
TNRC6C	LGG	chr17	76094488	76094488	G	T	Silent		2
TNRC6C	UCEC	chr17	76093836	76093836	G	T	Silent	p.P1436	2
TNRC6C	PAAD	chr17	76083142	76083142	C	A	Missense_Mutation		2
TNRC6C	BRCA	chr17	76089144	76089144	G	A	Nonsense_Mutation	p.W1364*	2
TNRC6C	STAD	chr17	76047106	76047107	-	G	Frame_Shift_Ins	p.W655fs	1
TNRC6C	LIHC	chr17	76047249	76047249	G	A	Silent		1
TNRC6C	LUAD	chr17	76046032	76046032	G	T	Missense_Mutation	p.A297S	1
TNRC6C	SARC	chr17	76045614	76045614	A	G	Silent	p.Q157Q	1
TNRC6C	SKCM	chr17	76060873	76060873	C	T	Silent	p.S819S	1
TNRC6C	BLCA	chr17	76094445	76094445	C	T	Missense_Mutation		1
TNRC6C	CESC	chr17	76099590	76099590	C	T	Silent		1
TNRC6C	HNSC	chr17	76045388	76045388	G	A	Missense_Mutation		1
TNRC6C	SKCM	chr17	76094577	76094577	G	A	Nonsense_Mutation	p.W1487X	1
TNRC6C	SKCM	chr17	76046315	76046315	C	T	Missense_Mutation	p.S391F	1
TNRC6C	BLCA	chr17	76047033	76047033	G	A	Nonsense_Mutation	p.W630*	1
TNRC6C	DLBC	chr17	76045908	76045908	C	T	Silent	p.N255N	1
TNRC6C	SKCM	chr17	76094577	76094577	G	A	Nonsense_Mutation	p.W1523*	1
TNRC6C	UCEC	chr17	76060963	76060963	G	A	Silent	p.P852P	1
TNRC6C	LIHC	chr17	76075517	76075517	A	G	Silent	p.A1084A	1
TNRC6C	LIHC	chr17	76075597	76075597	A	-	Frame_Shift_Del	p.Q1108fs	1
TNRC6C	LUAD	chr17	76079138	76079138	A	T	Missense_Mutation	p.Q1120L	1
TNRC6C	SARC	chr17	76100664	76100664	G	T	Missense_Mutation		1
TNRC6C	SKCM	chr17	76063945	76063945	C	T	Nonsense_Mutation	p.Q907X	1
TNRC6C	ESCA	chr17	76046827	76046827	G	T	Missense_Mutation		1
TNRC6C	ESCA	chr17	76063908	76063908	G	C	Missense_Mutation	p.E894D	1
TNRC6C	KIRP	chr17	76089791	76089791	C	G	Missense_Mutation	p.P1418R	1
TNRC6C	HNSC	chr17	76045219	76045219	G	A	Missense_Mutation		1
TNRC6C	UCS	chr17	76045946	76045946	G	A	Missense_Mutation		1
TNRC6C	LUAD	chr17	76087626	76087626	C	G	Missense_Mutation	p.P1300R	1
TNRC6C	SARC	chr17	76100760	76100760	C	T	Missense_Mutation	p.P1672L	1
TNRC6C	SKCM	chr17	76094571	76094571	C	T	Missense_Mutation	p.S1521F	1
TNRC6C	BLCA	chr17	76046718	76046718	C	A	Missense_Mutation		1
TNRC6C	SKCM	chr17	76094543	76094543	C	T	Missense_Mutation	p.P1476S	1
TNRC6C	SKCM	chr17	76075523	76075523	A	G	Silent	p.Q1083Q	1
TNRC6C	BLCA	chr17	76046718	76046718	C	A	Missense_Mutation	p.D525E	1
TNRC6C	DLBC	chr17	76063864	76063864	G	A	Missense_Mutation	p.G880S	1
TNRC6C	SKCM	chr17	76083070	76083070	C	T	Missense_Mutation	p.S1230L	1
TNRC6C	UCEC	chr17	76071243	76071243	G	A	Missense_Mutation	p.V982M	1
TNRC6C	LIHC	chr17	76082984	76082984	C	-	Frame_Shift_Del	p.R1201fs	1
TNRC6C	PAAD	chr17	76047129	76047153	CCCCCAACAGAACTGGGCTAGCAAA	-	Frame_Shift_Del	p.662_670del	1
TNRC6C	PRAD	chr17	76094486	76094486	C	G	Missense_Mutation	p.L1493V	1
TNRC6C	SARC	chr17	76046691	76046691	T	C	Silent		1
TNRC6C	ESCA	chr17	76046979	76046980	-	-	Frame_Shift_Ins		1
TNRC6C	HNSC	chr17	76060832	76060832	G	A	Missense_Mutation		1
TNRC6C	TGCT	chr17	76075489	76075489	A	G	Missense_Mutation	p.N1075S	1
TNRC6C	LIHC	chr17	76046589	76046589	A	G	Silent		1
TNRC6C	LIHC	chr17	76087679	76087679	A	G	Missense_Mutation	p.S1321G	1
TNRC6C	LUAD	chr17	76046235	76046235	G	C	Missense_Mutation	p.E364D	1
TNRC6C	SARC	chr17	76046367	76046367	A	G	Silent	p.E408E	1
TNRC6C	SKCM	chr17	76075568	76075568	T	C	Silent	p.L1098L	1
TNRC6C	BLCA	chr17	76046053	76046053	G	A	Missense_Mutation		1
TNRC6C	SKCM	chr17	76094543	76094543	C	T	Missense_Mutation	p.P1512S	1
TNRC6C	BLCA	chr17	76046637	76046637	G	A	Missense_Mutation	p.M498I	1
TNRC6C	SKCM	chr17	76089158	76089158	C	T	Missense_Mutation	p.S1369F	1
TNRC6C	UCEC	chr17	76060930	76060930	C	T	Silent	p.G841G	1
TNRC6C	READ	chr17	76067174	76067174	G	A	Silent	p.K929K	1
TNRC6C	SKCM	chr17	76089202	76089202	C	T	Missense_Mutation	p.P1387S	1
TNRC6C	HNSC	chr17	76089205	76089205	G	C	Missense_Mutation		1
TNRC6C	TGCT	chr17	76047438	76047438	C	T	Silent	p.T765T	1
TNRC6C	LIHC	chr17	76046560	76046560	G	A	Missense_Mutation		1
TNRC6C	LUAD	chr17	76060902	76060902	C	T	Missense_Mutation	p.A832V	1
TNRC6C	SARC	chr17	76047369	76047369	A	G	Silent	p.V742V	1
TNRC6C	SKCM	chr17	76094559	76094559	C	T	Missense_Mutation	p.P1517L	1
TNRC6C	BLCA	chr17	76046637	76046637	G	A	Missense_Mutation		1
TNRC6C	CESC	chr17	76060847	76060847	G	A	Missense_Mutation	p.E811K	1
TNRC6C	SKCM	chr17	76089054	76089054	G	C	Missense_Mutation	p.K1337N	1
TNRC6C	SKCM	chr17	76060871	76060871	T	G	Missense_Mutation	p.S819A	1
TNRC6C	BLCA	chr17	76046053	76046053	G	A	Missense_Mutation	p.A304T	1
TNRC6C	ESCA	chr17	76047107	76047107	G	-	Frame_Shift_Del	p.E657fs	1
TNRC6C	ESCA	chr17	76027743	76027743	C	G	Missense_Mutation		1
TNRC6C	SKCM	chr17	76060883	76060883	C	T	Silent	p.L823L	1
TNRC6C	HNSC	chr17	76060832	76060832	G	A	Missense_Mutation	p.V806I	1
TNRC6C	UCEC	chr17	76082939	76082939	G	A	Silent	p.A1189A	1
TNRC6C	LIHC	chr17	76099534	76099534	G	-	Frame_Shift_Del	p.G1574fs	1
TNRC6C	READ	chr17	76093868	76093868	C	T	Missense_Mutation	p.S1447L	1
TNRC6C	SKCM	chr17	76060964	76060964	G	A	Missense_Mutation	p.V850M	1
TNRC6C	KIRP	chr17	76046980	76046980	A	-	Frame_Shift_Del	p.K613fs	1
TNRC6C	HNSC	chr17	76094475	76094475	C	A	Missense_Mutation		1
TNRC6C	TGCT	chr17	76075489	76075489	A	G	Missense_Mutation	p.N1072S	1
TNRC6C	LIHC	chr17	76075481	76075481	G	T	Silent		1
TNRC6C	LIHC	chr17	76047470	76047470	A	T	Missense_Mutation	p.E776V	1
TNRC6C	LUAD	chr17	76061008	76061008	G	A	Silent	p.L867L	1
TNRC6C	SKCM	chr17	76087633	76087633	C	T	Silent	p.S1302S	1
TNRC6C	BLCA	chr17	76047001	76047001	G	C	Missense_Mutation		1
TNRC6C	SKCM	chr17	76089072	76089072	C	T	Silent	p.S1343S	1
TNRC6C	SKCM	chr17	76060870	76060870	C	T	Silent	p.S818S	1
TNRC6C	BLCA	chr17	76047001	76047001	G	C	Missense_Mutation	p.D620H	1
TNRC6C	SKCM	chr17	76046866	76046866	C	T	Missense_Mutation	p.P575S	1
TNRC6C	HNSC	chr17	76060832	76060832	G	A	Missense_Mutation	p.V809I	1
TNRC6C	UCEC	chr17	76083092	76083092	G	A	Silent	p.S1240S	1
TNRC6C	LIHC	chr17	76047078	76047078	A	-	Frame_Shift_Del	p.T645fs	1
TNRC6C	SARC	chr17	76046367	76046367	A	G	Silent		1
TNRC6C	SKCM	chr17	76045228	76045228	C	T	Nonsense_Mutation	p.Q29*	1
TNRC6C	ACC	chr17	76100842	76100842	C	T	Silent	p.S1699S	1
TNRC6C	GBM	chr17	76083173	76083173	C	T	Silent	p.A1268_splice	1
TNRC6C	KIRP	chr17	76060977	76060977	G	T	Missense_Mutation		1
TNRC6C	BLCA	chr17	76045934	76045934	G	T	Missense_Mutation		1
TNRC6C	COAD	chr17	76047174	76047174	T	A	Missense_Mutation	p.S677R	1
TNRC6C	HNSC	chr17	76060974	76060974	G	A	Missense_Mutation	p.G853E	1
TNRC6C	THCA	chr17	76089711	76089711	G	A	Silent		1
TNRC6C	LIHC	chr17	76069150	76069150	C	T	Silent		1
TNRC6C	LIHC	chr17	76094497	76094497	A	G	Silent	p.E1496E	1
TNRC6C	LUSC	chr17	76046155	76046155	G	A	Missense_Mutation	p.G338S	1
TNRC6C	SARC	chr17	76045614	76045614	A	G	Silent	p.Q157	1
TNRC6C	SKCM	chr17	76045883	76045883	C	T	Missense_Mutation	p.S247F	1
TNRC6C	SKCM	chr17	76098601	76098601	C	T	Silent	p.L1516L	1
TNRC6C	SKCM	chr17	76045448	76045448	C	T	Missense_Mutation	p.P102L	1
TNRC6C	BLCA	chr17	76045934	76045934	G	T	Missense_Mutation	p.G264V	1
TNRC6C	ESCA	chr17	76063981	76063981	G	T	Missense_Mutation	p.A919S	1
TNRC6C	SKCM	chr17	76083169	76083169	C	T	Missense_Mutation	p.P1263L	1
TNRC6C	HNSC	chr17	76089205	76089205	G	C	Missense_Mutation	p.E1388Q	1
TNRC6C	UCEC	chr17	76063981	76063981	G	A	Missense_Mutation	p.A919T	1
TNRC6C	LIHC	chr17	76060857	76060857	G	-	Frame_Shift_Del	p.W814fs	1
TNRC6C	PAAD	chr17	76083142	76083142	C	A	Missense_Mutation	p.S1254Y	1
TNRC6C	SARC	chr17	76063967	76063967	G	T	Missense_Mutation		1
TNRC6C	SKCM	chr17	76045287	76045287	G	T	Silent	p.A48A	1
TNRC6C	CESC	chr17	76046539	76046539	C	A	Missense_Mutation		1
TNRC6C	GBM	chr17	76083173	76083173	C	T	Silent		1
TNRC6C	KIRP	chr17	76089201	76089201	C	A	Silent		1
TNRC6C	COAD	chr17	76047372	76047372	C	T	Silent	p.N743N	1
TNRC6C	THCA	chr17	76046475	76046475	G	A	Silent	p.L444L	1
TNRC6C	LIHC	chr17	76069163	76069163	G	T	Missense_Mutation		1
TNRC6C	LUSC	chr17	76099517	76099517	C	T	Missense_Mutation	p.T1532I	1
TNRC6C	SARC	chr17	76047369	76047369	A	G	Silent	p.V742	1
TNRC6C	SKCM	chr17	76063945	76063945	C	T	Nonsense_Mutation	p.Q904*	1
TNRC6C	SKCM	chr17	76083169	76083169	C	T	Missense_Mutation	p.P1266L	1
TNRC6C	SKCM	chr17	76046630	76046630	C	T	Missense_Mutation	p.S496F	1
TNRC6C	BLCA	chr17	76045867	76045867	G	T	Nonsense_Mutation	p.E242*	1
TNRC6C	ESCA	chr17	76061018	76061018	G	T	Missense_Mutation	p.A868S	1
TNRC6C	HNSC	chr17	76094475	76094475	C	A	Missense_Mutation	p.T1453K	1
TNRC6C	UCEC	chr17	76046610	76046611	-	G	Frame_Shift_Ins	p.S489fs	1
TNRC6C	LIHC	chr17	76045801	76045801	C	-	Frame_Shift_Del	p.P220fs	1
TNRC6C	PAAD	chr17	76089140	76089140	G	A	Missense_Mutation	p.S1363N	1
TNRC6C	LUAD	chr17	76063980	76063980	C	A	Missense_Mutation	p.N915K	1
TNRC6C	SARC	chr17	76027739	76027739	G	T	Missense_Mutation		1
TNRC6C	SARC	chr17	76045758	76045758	G	T	Silent		1
TNRC6C	SKCM	chr17	76067190	76067190	G	A	Missense_Mutation	p.D932N	1
TNRC6C	ACC	chr17	76067213	76067213	G	C	Silent	p.R939R	1
TNRC6C	GBM	chr17	76089149	76089149	G	A	Missense_Mutation		1
TNRC6C	STAD	chr17	76079238	76079238	G	T	Missense_Mutation	p.Q1153H	1
TNRC6C	LGG	chr17	76094488	76094488	G	T	Silent	p.L1493L	1
TNRC6C	BLCA	chr17	76079209	76079209	C	T	Missense_Mutation	p.H1144Y	1
TNRC6C	COAD	chr17	76083032	76083032	C	A	Silent	p.P1220P	1
TNRC6C	THYM	chr17	76063945	76063945	C	A	Missense_Mutation	p.Q907K	1
TNRC6C	LIHC	chr17	76046753	76046753	G	-	Frame_Shift_Del	p.W537fs	1
TNRC6C	MESO	chr17	76083171	76083171	C	A	Missense_Mutation		1
TNRC6C	SKCM	chr17	76045228	76045228	C	T	Nonsense_Mutation	p.Q29X	1
TNRC6C	SKCM	chr17	76046938	76046938	T	C	Missense_Mutation	p.W599R	1
TNRC6C	BLCA	chr17	76079209	76079209	C	T	Missense_Mutation	p.H1147Y	1
TNRC6C	ESCA	chr17	76082657	76082657	A	G	Missense_Mutation	p.Q1181R	1
TNRC6C	ESCA	chr17	76082657	76082657	A	G	Missense_Mutation	p.Q1184R	1
TNRC6C	KICH	chr17	76071339	76071339	C	T	Missense_Mutation		1
TNRC6C	LIHC	chr17	76046028	76046028	A	-	Frame_Shift_Del	p.G295fs	1
TNRC6C	PAAD	chr17	76060855	76060855	T	C	Silent	p.S813S	1
TNRC6C	SARC	chr17	76046138	76046138	G	T	Missense_Mutation		1
TNRC6C	SARC	chr17	76099592	76099592	G	T	Missense_Mutation		1
TNRC6C	SKCM	chr17	76089202	76089202	C	T	Missense_Mutation	p.P1384S	1
TNRC6C	BLCA	chr17	76047083	76047083	C	T	Missense_Mutation		1
TNRC6C	HNSC	chr17	76046980	76046980	A	G	Missense_Mutation		1
TNRC6C	STAD	chr17	76089061	76089061	A	G	Missense_Mutation	p.I1340V	1
TNRC6C	LGG	chr17	76045849	76045849	G	A	Missense_Mutation	p.V236I	1
TNRC6C	BLCA	chr17	76089176	76089176	C	T	Missense_Mutation	p.S1375L	1
TNRC6C	HNSC	chr17	76094475	76094475	C	A	Missense_Mutation	p.T1489K	1
TNRC6C	THYM	chr17	76045266	76045266	A	G	Silent	p.G41G	1
TNRC6C	LIHC	chr17	76045435	76045435	C	A	Missense_Mutation	p.L98I	1
TNRC6C	LIHC	chr17	76071341	76071341	C	-	Frame_Shift_Del	p.R1011fs	1
TNRC6C	OV	chr17	76046839	76046839	G	T	Missense_Mutation	p.D566Y	1
TNRC6C	SKCM	chr17	76045832	76045832	G	A	Missense_Mutation	p.G230E	1
TNRC6C	SKCM	chr17	76060883	76060883	C	T	Silent	p.L826L	1
TNRC6C	BLCA	chr17	76089176	76089176	C	T	Missense_Mutation	p.S1378L	1
TNRC6C	ESCA	chr17	76100682	76100682	C	T	Missense_Mutation		1
TNRC6C	LIHC	chr17	76046711	76046711	G	-	Frame_Shift_Del	p.W523fs	1
TNRC6C	SARC	chr17	76067213	76067213	G	T	Silent		1
TNRC6C	SARC	chr17	76087618	76087618	G	T	Missense_Mutation		1
TNRC6C	SKCM	chr17	76089763	76089763	G	A	Missense_Mutation	p.V1406I	1
TNRC6C	BLCA	chr17	76079209	76079209	C	T	Missense_Mutation		1
TNRC6C	HNSC	chr17	76046391	76046391	G	A	Silent		1
TNRC6C	STAD	chr17	76046405	76046405	G	T	Missense_Mutation	p.R421M	1
TNRC6C	LGG	chr17	76047335	76047335	G	-	Frame_Shift_Del	p.W731fs	1
TNRC6C	COAD	chr17	76087620	76087620	C	T	Missense_Mutation	p.T1301M	1
TNRC6C	THYM	chr17	76046788	76046788	G	A	Missense_Mutation	p.A549T	1
TNRC6C	LIHC	chr17	76046560	76046560	G	A	Missense_Mutation	p.D473N	1
TNRC6C	LIHC	chr17	76046036	76046036	G	-	Frame_Shift_Del	p.W298fs	1
TNRC6C	SKCM	chr17	76075523	76075523	A	G	Silent	p.Q1086Q	1
TNRC6C	SKCM	chr17	76045529	76045529	C	T	Missense_Mutation	p.P129L	1
TNRC6C	SKCM	chr17	76094559	76094559	C	T	Missense_Mutation	p.P1481L	1
TNRC6C	ESCA	chr17	76047107	76047107	G	-	Frame_Shift_Del		1
TNRC6C	ESCA	chr17	76083023	76083023	G	T	Silent	p.P1217P	1
TNRC6C	KIRP	chr17	76045429	76045429	A	G	Missense_Mutation	p.I96V	1
TNRC6C	LIHC	chr17	76046929	76046929	G	-	Frame_Shift_Del	p.G597fs	1
TNRC6C	SARC	chr17	76083122	76083122	G	A	Silent		1
TNRC6C	SARC	chr17	76027758	76027758	C	T	Missense_Mutation		1
TNRC6C	SKCM	chr17	76083028	76083028	C	T	Missense_Mutation	p.P1216L	1
TNRC6C	BLCA	chr17	76089176	76089176	C	T	Missense_Mutation		1
TNRC6C	HNSC	chr17	76082941	76082941	G	A	Missense_Mutation		1
TNRC6C	STAD	chr17	76046806	76046806	G	T	Missense_Mutation	p.G555C	1
TNRC6C	BLCA	chr17	76094445	76094445	C	T	Missense_Mutation	p.S1479L	1
TNRC6C	COAD	chr17	76089762	76089762	C	T	Silent	p.D1408D	1
TNRC6C	SKCM	chr17	76089185	76089185	C	T	Missense_Mutation	p.S1378F	1
TNRC6C	HNSC	chr17	76082941	76082941	G	A	Missense_Mutation	p.R1187H	1
TNRC6C	THYM	chr17	76046788	76046788	G	A	Missense_Mutation		1
TNRC6C	LIHC	chr17	76075532	76075532	C	T	Silent	p.T1089T	1
TNRC6C	LIHC	chr17	76047179	76047179	G	-	Frame_Shift_Del	p.W679fs	1
TNRC6C	SKCM	chr17	76094571	76094571	C	T	Missense_Mutation	p.S1485F	1
TNRC6C	SKCM	chr17	76046879	76046879	C	T	Missense_Mutation	p.S579F	1
TNRC6C	SKCM	chr17	76089158	76089158	C	T	Missense_Mutation	p.S1372F	1
TNRC6C	ESCA	chr17	76099514	76099514	G	T	Missense_Mutation		1
TNRC6C	ESCA	chr17	76061018	76061018	G	T	Missense_Mutation	p.A871S	1
TNRC6C	STAD	chr17	76099610	76099610	C	T	Missense_Mutation	p.A1599V	1
TNRC6C	KIRP	chr17	76087521	76087521	C	G	Missense_Mutation	p.A1268G	1
TNRC6C	LIHC	chr17	76046970	76046970	G	-	Frame_Shift_Del	p.L609fs	1
TNRC6C	PAAD	chr17	76047298	76047298	C	A	Missense_Mutation		1

Copy number variation (CNV) of TNRC6C
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TNRC6C
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
78250	LUAD	TCGA-38-4630-01A	AFMID	chr17	76187141	+	TNRC6C	chr17	76060803	+
78250	N/A	FN136800	AVEN	chr15	34208726	-	TNRC6C	chr17	75967463	+
78250	OV	TCGA-31-1951	ENGASE	chr17	77076446	+	TNRC6C	chr17	76082583	+
78250	OV	TCGA-31-1951-01A	ENGASE	chr17	77076446	+	TNRC6C	chr17	76082584	+
78250	STAD	TCGA-CG-5717-01A	PLEKHA2	chr8	38814904	+	TNRC6C	chr17	76079128	+
78250	GBM	TCGA-06-5856-01A	RPUSD3	chr3	9885149	-	TNRC6C	chr17	76089701	+
92906	N/A	AI371982	TNRC6C	chr17	76100746	-	ALG2	chr9	101980528	+
98193	BRCA	TCGA-D8-A27N-01A	TNRC6C	chr17	76089205	+	APPBP2	chr17	58577848	-
92906	N/A	KR072911	TNRC6C	chr17	76020971	-	FARS2	chr6	5473477	+
102615	LUSC	TCGA-56-A4BY-01A	TNRC6C	chr17	76001160	+	PHACTR1	chr6	13287295	+
100584	BRCA	TCGA-A2-A1FW	TNRC6C	chr17	76075622	+	PLCB4	chr20	9433993	+
100584	BRCA	TCGA-A2-A1FW	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433993	+
100584	BRCA	TCGA-A2-A1FW-01A	TNRC6C	chr17	76075622	+	PLCB4	chr20	9433994	+
100584	BRCA	TCGA-A2-A1FW-01A	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
92906	STAD	TCGA-CD-5799-01A	TNRC6C	chr17	76102650	+	RAB7A	chr3	128532395	+
101978	N/A	BI021858	TNRC6C	chr17	76089913	-	RIN3	chr14	93097760	-
100926	UVM	TCGA-WC-A884-01A	TNRC6C	chr17	76001160	+	RPTOR	chr17	78704360	+
101750	BRCA	TCGA-C8-A1HI-01A	TNRC6C	chr17	76047529	+	SCAPER	chr15	76697020	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	TNRC6C	0.000255226712990539	0.0071
LIHC	TNRC6C	0.00873482977411716	0.24
LUAD	TNRC6C	0.00953263462057139	0.25
HNSC	TNRC6C	0.0170507438871902	0.43
KICH	TNRC6C	0.0339021848689683	0.81
BRCA	TNRC6C	0.0360848614174654	0.83

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	TNRC6C	0.0122745671067292	0.39
KIRC	TNRC6C	0.0216515760255284	0.65
LGG	TNRC6C	0.03201200800558	0.93
THYM	TNRC6C	0.000118520747519716	0.0039
SARC	TNRC6C	0.0179525800450184	0.56

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source