Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL8 (NCBI Gene ID:6132)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL8
	Gene ID: 6132
	Gene Symbol	RPL8
	Gene ID	6132
	Gene Name	ribosomal protein L8
	Synonyms	L8
	Cytomap	8q24.3
	Type of Gene	protein-coding
	Description	60S ribosomal protein L8large ribosomal subunit protein uL2
	Modification date	20200327
	UniProtAcc	P62917

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL8	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL8	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'RPL8[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL8	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000262584	146015739	146015855	Frame-shift
ENST00000394920	146015739	146015855	Frame-shift
ENST00000528957	146015739	146015855	Frame-shift
ENST00000262584	146016661	146016880	In-frame
ENST00000394920	146016661	146016880	In-frame
ENST00000528957	146016661	146016880	In-frame
ENST00000262584	146017376	146017525	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000394920	146016661	146016880	982	437	655	257	93	166
ENST00000528957	146016661	146016880	1032	503	721	257	93	166
ENST00000262584	146016661	146016880	1058	514	732	257	93	166

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15489334,ECO:0000269\|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	RPL8	-4.84588284974558	0.00110314154326131
KIRC	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL8	-1.53003692350119	6.0301274061203e-05

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	RPL8	1	2	0.00770570003797883	0.18096862745098	0.236749007561437	-1.364636527509	-1.08739342731965
KICH	RPL8	1	2	0.0186025880435652	0.141049358974359	0.250290384615385	0.937683985312062	0.365686549415631
TGCT	RPL8	1	2	0.014749855668119	0.148698175182482	0.208786842105263	0.198860552783978	-0.337057580139347
UCS	RPL8	1	2	0.0464178015275538	0.189851666666667	0.228430357142857	-0.02315652750696	0.291042043921524

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KICH	RPL8	0.074660989	0.005302707
MESO	RPL8	0.084121836	0.008797755
GBM	RPL8	0.234757899	0.026972995

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL8 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	IUPHAR	RPL8	TOP1MT	0.823430295	1.55E-301
CHOL	Cell metabolism gene	RPL8	SNRPD2	0.831383808	1.54E-12
CHOL	Epifactor	RPL8	FBL	0.824032401	3.56E-12
CHOL	TSG	RPL8	GAS5	0.804199857	2.86E-11
DLBC	Cell metabolism gene	RPL8	GEMIN7	0.811735978	2.57E-12
DLBC	Cell metabolism gene	RPL8	SNRPD2	0.814059191	1.98E-12
DLBC	Cell metabolism gene	RPL8	EXOSC4	0.814516204	1.89E-12
DLBC	Cell metabolism gene	RPL8	FAU	0.856167555	8.74E-15
DLBC	Cell metabolism gene	RPL8	NME2	0.864911779	2.28E-15
DLBC	Cell metabolism gene	RPL8	TIMM9	0.88416299	8.23E-17
DLBC	CGC	RPL8	NACA	0.82710598	4.33E-13
DLBC	Epifactor	RPL8	EXOSC4	0.814516204	1.89E-12
DLBC	Epifactor	RPL8	FBL	0.825609789	5.18E-13
DLBC	IUPHAR	RPL8	SLC39A4	0.824734333	5.76E-13
DLBC	TF	RPL8	NME2	0.864911779	2.28E-15
DLBC	TF	RPL8	ZNF581	0.871552899	7.70E-16
DLBC	TSG	RPL8	GLTSCR2	0.80651109	4.54E-12
DLBC	TSG	RPL8	GADD45GIP1	0.813645835	2.08E-12
DLBC	TSG	RPL8	SLC39A4	0.824734333	5.76E-13
DLBC	TSG	RPL8	GNB2L1	0.921123194	1.79E-20
GBM	Cell metabolism gene	RPL8	SSR2	0.812836924	9.42E-42
KIRP	Cell metabolism gene	RPL8	SNRPD2	0.809328188	3.61E-76
KIRP	Cell metabolism gene	RPL8	FAU	0.815521964	3.09E-78
LGG	Cell metabolism gene	RPL8	EXOSC4	0.801988167	3.03E-120
LGG	Cell metabolism gene	RPL8	FAU	0.856304226	1.25E-153
LGG	Epifactor	RPL8	EXOSC4	0.801988167	3.03E-120
LGG	TSG	RPL8	GNB2L1	0.807633763	3.31E-123
LIHC	Cell metabolism gene	RPL8	EXOSC4	0.855400744	2.39E-122
LIHC	Epifactor	RPL8	EXOSC4	0.855400744	2.39E-122
LIHC	IUPHAR	RPL8	TOP1MT	0.810578064	7.08E-100
LIHC	TF	RPL8	HSF1	0.833718169	1.22E-110
PRAD	Cell metabolism gene	RPL8	FAU	0.800598002	5.48E-124
PRAD	Cell metabolism gene	RPL8	EXOSC4	0.82053722	3.17E-135
PRAD	Epifactor	RPL8	FBL	0.800784381	4.36E-124
PRAD	Epifactor	RPL8	EXOSC4	0.82053722	3.17E-135
PRAD	TF	RPL8	HSF1	0.805388839	1.44E-126
PRAD	TSG	RPL8	GNB2L1	0.804225084	6.19E-126
READ	Cell metabolism gene	RPL8	EXOSC4	0.81804513	1.73E-26
READ	Epifactor	RPL8	EXOSC4	0.81804513	1.73E-26
TGCT	Cell metabolism gene	RPL8	TIMM13	0.801583763	3.17E-36
TGCT	Cell metabolism gene	RPL8	EXOSC4	0.815559461	2.04E-38
TGCT	Epifactor	RPL8	EXOSC4	0.815559461	2.04E-38
TGCT	IUPHAR	RPL8	TOP1MT	0.845072997	1.01E-43
TGCT	TF	RPL8	HSF1	0.809731961	1.76E-37
THCA	Cell metabolism gene	RPL8	GPX4	0.800518725	7.59E-129
THCA	Cell metabolism gene	RPL8	SNRPD2	0.839046833	8.28E-153
THCA	Cell metabolism gene	RPL8	FAU	0.870283912	1.91E-177
THCA	TF	RPL8	ZNF524	0.835512007	2.35E-150
THCA	TSG	RPL8	GNB2L1	0.880683864	4.15E-187
THYM	Cell metabolism gene	RPL8	POLR2F	0.802993978	9.62E-29
THYM	Cell metabolism gene	RPL8	GSTZ1	0.803536161	8.30E-29
THYM	Cell metabolism gene	RPL8	ALG3	0.803703192	7.93E-29
THYM	Cell metabolism gene	RPL8	SNRPD2	0.804855591	5.78E-29
THYM	Cell metabolism gene	RPL8	GEMIN7	0.8049256	5.67E-29
THYM	Cell metabolism gene	RPL8	POLR2H	0.80505134	5.47E-29
THYM	Cell metabolism gene	RPL8	ECHS1	0.80573855	4.53E-29
THYM	Cell metabolism gene	RPL8	PSMC5	0.809209877	1.71E-29
THYM	Cell metabolism gene	RPL8	GPAA1	0.809449581	1.60E-29
THYM	Cell metabolism gene	RPL8	TOMM7	0.810711537	1.12E-29
THYM	Cell metabolism gene	RPL8	PMPCA	0.812087478	7.55E-30
THYM	Cell metabolism gene	RPL8	TIMM10	0.812888091	6.00E-30
THYM	Cell metabolism gene	RPL8	SSR2	0.814998659	3.25E-30
THYM	Cell metabolism gene	RPL8	MMAB	0.815493691	2.81E-30
THYM	Cell metabolism gene	RPL8	GMPPA	0.8157529	2.60E-30
THYM	Cell metabolism gene	RPL8	TIMM8B	0.817506995	1.55E-30
THYM	Cell metabolism gene	RPL8	ATP5G1	0.81850239	1.15E-30
THYM	Cell metabolism gene	RPL8	DPM3	0.819077882	9.70E-31
THYM	Cell metabolism gene	RPL8	EXOSC5	0.820012405	7.33E-31
THYM	Cell metabolism gene	RPL8	LCMT1	0.821576416	4.56E-31
THYM	Cell metabolism gene	RPL8	GFER	0.822437179	3.51E-31
THYM	Cell metabolism gene	RPL8	HMBS	0.828672122	5.00E-32
THYM	Cell metabolism gene	RPL8	SLC27A5	0.829249883	4.16E-32
THYM	Cell metabolism gene	RPL8	TIMM50	0.83362967	1.01E-32
THYM	Cell metabolism gene	RPL8	PFDN5	0.833739274	9.69E-33
THYM	Cell metabolism gene	RPL8	IMPDH2	0.835559591	5.30E-33
THYM	Cell metabolism gene	RPL8	NME2	0.835707121	5.05E-33
THYM	Cell metabolism gene	RPL8	PHPT1	0.837610478	2.66E-33
THYM	Cell metabolism gene	RPL8	PYCRL	0.839664413	1.32E-33
THYM	Cell metabolism gene	RPL8	TIMM13	0.841762019	6.42E-34
THYM	Cell metabolism gene	RPL8	FAU	0.842119567	5.67E-34
THYM	Cell metabolism gene	RPL8	MIF	0.844641124	2.33E-34
THYM	Cell metabolism gene	RPL8	DPM2	0.847301408	9.00E-35
THYM	Cell metabolism gene	RPL8	MTX1	0.847613864	8.04E-35
THYM	Cell metabolism gene	RPL8	PTGES2	0.850385735	2.91E-35
THYM	Cell metabolism gene	RPL8	PGLS	0.85191509	1.65E-35
THYM	Cell metabolism gene	RPL8	POLR2I	0.853216642	1.01E-35
THYM	Cell metabolism gene	RPL8	GSTP1	0.858975045	1.10E-36
THYM	Cell metabolism gene	RPL8	EXOSC4	0.881186233	7.47E-41
THYM	CGC	RPL8	ASPSCR1	0.83690034	3.39E-33
THYM	Epifactor	RPL8	PRPF31	0.809980318	1.38E-29
THYM	Epifactor	RPL8	EXOSC5	0.820012405	7.33E-31
THYM	Epifactor	RPL8	SIRT6	0.830838661	2.50E-32
THYM	Epifactor	RPL8	FBL	0.858693669	1.23E-36
THYM	Epifactor	RPL8	EXOSC4	0.881186233	7.47E-41
THYM	IUPHAR	RPL8	SIRT3	0.816179941	2.30E-30
THYM	IUPHAR	RPL8	SLC27A5	0.829249883	4.16E-32
THYM	IUPHAR	RPL8	SIRT6	0.830838661	2.50E-32
THYM	IUPHAR	RPL8	IMPDH2	0.835559591	5.30E-33
THYM	IUPHAR	RPL8	PTGES2	0.850385735	2.91E-35
THYM	TF	RPL8	CENPB	0.801832068	1.32E-28
THYM	TF	RPL8	REXO4	0.807803777	2.55E-29
THYM	TF	RPL8	THAP7	0.822884918	3.06E-31
THYM	TF	RPL8	ZBTB48	0.823311878	2.68E-31
THYM	TF	RPL8	ZNF787	0.833222601	1.15E-32
THYM	TF	RPL8	NME2	0.835707121	5.05E-33
THYM	TF	RPL8	ZNF524	0.83804427	2.30E-33
THYM	TF	RPL8	ZNF581	0.886402189	5.93E-42
THYM	TSG	RPL8	PHB	0.815582945	2.74E-30
THYM	TSG	RPL8	SIRT3	0.816179941	2.30E-30
THYM	TSG	RPL8	ZBTB48	0.823311878	2.68E-31
THYM	TSG	RPL8	TSSC4	0.830761896	2.56E-32
THYM	TSG	RPL8	SIRT6	0.830838661	2.50E-32
THYM	TSG	RPL8	STUB1	0.83815594	2.21E-33
THYM	TSG	RPL8	GADD45GIP1	0.85571668	3.90E-36
THYM	TSG	RPL8	GSTP1	0.858975045	1.10E-36
UCS	Cell metabolism gene	RPL8	POLR2F	0.802993978	9.62E-29
UCS	Cell metabolism gene	RPL8	GSTZ1	0.803536161	8.30E-29
UCS	Cell metabolism gene	RPL8	ALG3	0.803703192	7.93E-29
UCS	Cell metabolism gene	RPL8	SNRPD2	0.804855591	5.78E-29
UCS	Cell metabolism gene	RPL8	GEMIN7	0.8049256	5.67E-29
UCS	Cell metabolism gene	RPL8	POLR2H	0.80505134	5.47E-29
UCS	Cell metabolism gene	RPL8	ECHS1	0.80573855	4.53E-29
UCS	Cell metabolism gene	RPL8	PSMC5	0.809209877	1.71E-29
UCS	Cell metabolism gene	RPL8	GPAA1	0.809449581	1.60E-29
UCS	Cell metabolism gene	RPL8	TOMM7	0.810711537	1.12E-29
UCS	Cell metabolism gene	RPL8	PMPCA	0.812087478	7.55E-30
UCS	Cell metabolism gene	RPL8	TIMM10	0.812888091	6.00E-30
UCS	Cell metabolism gene	RPL8	SSR2	0.814998659	3.25E-30
UCS	Cell metabolism gene	RPL8	MMAB	0.815493691	2.81E-30
UCS	Cell metabolism gene	RPL8	GMPPA	0.8157529	2.60E-30
UCS	Cell metabolism gene	RPL8	TIMM8B	0.817506995	1.55E-30
UCS	Cell metabolism gene	RPL8	ATP5G1	0.81850239	1.15E-30
UCS	Cell metabolism gene	RPL8	DPM3	0.819077882	9.70E-31
UCS	Cell metabolism gene	RPL8	EXOSC5	0.820012405	7.33E-31
UCS	Cell metabolism gene	RPL8	LCMT1	0.821576416	4.56E-31
UCS	Cell metabolism gene	RPL8	GFER	0.822437179	3.51E-31
UCS	Cell metabolism gene	RPL8	HMBS	0.828672122	5.00E-32
UCS	Cell metabolism gene	RPL8	SLC27A5	0.829249883	4.16E-32
UCS	Cell metabolism gene	RPL8	TIMM50	0.83362967	1.01E-32
UCS	Cell metabolism gene	RPL8	PFDN5	0.833739274	9.69E-33
UCS	Cell metabolism gene	RPL8	IMPDH2	0.835559591	5.30E-33
UCS	Cell metabolism gene	RPL8	NME2	0.835707121	5.05E-33
UCS	Cell metabolism gene	RPL8	PHPT1	0.837610478	2.66E-33
UCS	Cell metabolism gene	RPL8	PYCRL	0.839664413	1.32E-33
UCS	Cell metabolism gene	RPL8	TIMM13	0.841762019	6.42E-34
UCS	Cell metabolism gene	RPL8	FAU	0.842119567	5.67E-34
UCS	Cell metabolism gene	RPL8	MIF	0.844641124	2.33E-34
UCS	Cell metabolism gene	RPL8	DPM2	0.847301408	9.00E-35
UCS	Cell metabolism gene	RPL8	MTX1	0.847613864	8.04E-35
UCS	Cell metabolism gene	RPL8	PTGES2	0.850385735	2.91E-35
UCS	Cell metabolism gene	RPL8	PGLS	0.85191509	1.65E-35
UCS	Cell metabolism gene	RPL8	POLR2I	0.853216642	1.01E-35
UCS	Cell metabolism gene	RPL8	GSTP1	0.858975045	1.10E-36
UCS	Cell metabolism gene	RPL8	EXOSC4	0.881186233	7.47E-41
UCS	CGC	RPL8	ASPSCR1	0.83690034	3.39E-33
UCS	Epifactor	RPL8	PRPF31	0.809980318	1.38E-29
UCS	Epifactor	RPL8	EXOSC5	0.820012405	7.33E-31
UCS	Epifactor	RPL8	SIRT6	0.830838661	2.50E-32
UCS	Epifactor	RPL8	FBL	0.858693669	1.23E-36
UCS	Epifactor	RPL8	EXOSC4	0.881186233	7.47E-41
UCS	IUPHAR	RPL8	SIRT3	0.816179941	2.30E-30
UCS	IUPHAR	RPL8	SLC27A5	0.829249883	4.16E-32
UCS	IUPHAR	RPL8	SIRT6	0.830838661	2.50E-32
UCS	IUPHAR	RPL8	IMPDH2	0.835559591	5.30E-33
UCS	IUPHAR	RPL8	PTGES2	0.850385735	2.91E-35
UCS	TF	RPL8	CENPB	0.801832068	1.32E-28
UCS	TF	RPL8	REXO4	0.807803777	2.55E-29
UCS	TF	RPL8	THAP7	0.822884918	3.06E-31
UCS	TF	RPL8	ZBTB48	0.823311878	2.68E-31
UCS	TF	RPL8	ZNF787	0.833222601	1.15E-32
UCS	TF	RPL8	NME2	0.835707121	5.05E-33
UCS	TF	RPL8	ZNF524	0.83804427	2.30E-33
UCS	TF	RPL8	ZNF581	0.886402189	5.93E-42
UCS	TSG	RPL8	PHB	0.815582945	2.74E-30
UCS	TSG	RPL8	SIRT3	0.816179941	2.30E-30
UCS	TSG	RPL8	ZBTB48	0.823311878	2.68E-31
UCS	TSG	RPL8	TSSC4	0.830761896	2.56E-32
UCS	TSG	RPL8	SIRT6	0.830838661	2.50E-32
UCS	TSG	RPL8	STUB1	0.83815594	2.21E-33
UCS	TSG	RPL8	GADD45GIP1	0.85571668	3.90E-36
UCS	TSG	RPL8	GSTP1	0.858975045	1.10E-36
UVM	IUPHAR	RPL8	TOP1MT	0.926534389	7.42E-35

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL8	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL8	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL8	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL8	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL8	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL8	RPS11	-1.01861570565103	0.00105937570333481
PRAD	RPL8	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL8	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL8	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL8	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL8	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL8	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL8	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL8	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL8	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL8	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL8	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL8	RPS23	-2.03658159814007	0.046875
KIRC	RPL8	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL8	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL8	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL8	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL8	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL8	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL8	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL8	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL8	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL8	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL8

C11orf49, ST3GAL3, ARL15, FGFR3, NUDT3, Supt5, ARIH2, NOP56, EBNA-LP, CHDH, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPL4, RPL30, RPL6, RPS13, RPL10A, RPL15, RPL18A, RPL18, RPL21, RPL23A, RPL23, RPL3, RPL5, RPL7A, RPL9, RPS16, RPS23, RPS2, RPS3A, RPS3, RPS4X, RPS6, RPS8, RPSA, RPL19, RPL14, RPL7, RPS26, RPL12, RPS20, RPS9, RPL11, RPL10, RPL31, RPS17, RPL27A, RPLP0, RPL36, RPL38, RPL17, RPL29, RPL32, ILF3, ILF2, NCL, EIF3C, EIF4A1, EEF1G, TUFM, RPLP0P6, MRPL23, TXN2, CDH2, PPT2, HSPA5, RPL10L, HSPA8, ATF7IP, TUBA1C, ESR1, MAGOH, EIF4A3, PA2G4, VCAM1, FN1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, DPH3, UPF2, FBXO6, TARDBP, PARK2, RPL28, RPS25, ZBTB1, STAU1, CEP250, TP53, TUBGCP3, HUWE1, CUL7, OBSL1, CCDC8, UBE2I, EED, EBNA1BP2, RPL26L1, RPLP2, CCDC137, RBM28, POP1, DDX24, FTSJ3, ZNF668, DKC1, STAU2, DDX27, GLYR1, REXO4, WHSC1, C7orf50, RRP8, PAPD5, ZC3HAV1, NOP2, GNL2, CCDC86, RBM34, MINA, LIN28B, KIAA0020, RPL13A, RPL37A, RSBN1L, RPF2, RPS24, ZNF770, RPS6KB2, NTRK1, EIF6, PES1, RPL13, RPL22, RPL24, RPL26, RPL34, RPL35A, RPL3L, DDX18, HIRIP3, MRPL24, MRPL4, MRPS7, PABPC4, RPL27, RPL35, RPS10, RPS27, RPS5, RPS11, RPS14, RPS15, RPS15A, RPS18, RPS19, LOC101929876, RPS29, RPS7, TUBB4B, SFN, EWSR1, XPO1, HNRNPU, NPM1, Eif3a, Eif3e, Srp72, Rrbp1, Ccdc9, GAN, NF2, Ksr1, RC3H1, ZNF746, RRS1, MECP2, PRDM5, CNBP, ZNF512, H2AFX, PINX1, ZBTB24, H2AFY2, CYLD, INO80B, TRIM25, HEY1, BRCA1, MTF1, CFTR, UBA2, TMPO, PPP1CC, APOE, BCL2L1, BMP4, WDR77, KRAS, PCBP1, PPIE, PPP6C, TRIP4, API5, CTNNB1, DIMT1, MAP2K1, MATN2, MED9, UBE2M, PYHIN1, PRPF8, AAR2, PIH1D1, EFTUD2, RNF4, CHD3, CHD4, LARP7, RIOK1, HEXIM1, MEPCE, SNAI1, AGR2, RECQL4, REST, MYC, Prkaa1, Prkab1, FBL, HIST1H3A, AURKAIP1, ZNF598, GRWD1, METTL14, RC3H2, ESR2, PHB, TGFBR2, FAF1, RBX1, KIN, NR2C2, VRK1, HIST1H4A, SNRNP70, ITFG1, HMGB1, BIRC3, NFX1, WWP2, BRD7, MATR3, SOX2, PLEKHA4, FANCD2, ZC3H18, MAP3K14, PRKAR1A, PTPN6, PTPRJ, IGSF1, LRRC59, RRBP1, E, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF7a, ORF7b, ORF8, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, INS, NMRAL1, NDN, Rnf183, BRD4, RBM45, Apc2, RBM39, FBP1, LGALS9, IFI16, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC25, DNAJC2, DRG1, SETD8, TSPYL5, ATXN2L, CBX4, METTL17, KDM2A, SP100, NUFIP2, DCAF13, KDF1, OGT, DDRGK1, UFL1, ELOVL5, TRIM37, ATG3, WDR5, PAGE4, NUDCD2, NAA40, PRKRA, GZF1, SRSF1, DDX21, RSL1D1, DDX31, ZC3H10, H1FOO, CBX6, RPL7L1, BRIX1, ZNF354A, DHX8, NMNAT1, TAF1C, C1QBP, HIST1H1A, CCDC140, SRSF6, ZCCHC7, UTP23, SPPL3, TTF1, SURF6, TAF1A, PRDM15, ZNF48, TAF1D, NPM3, NOC3L, MYBBP1A, RBM4B, TUBA8, BUD13, SPECC1L, XRN1, NIFK, NKRF, MPHOSPH10, SPATS2L, THAP3, GTPBP4, RBMX2, SRSF5, RRP1B, KNOP1, DDX54, IL17B, YTHDC2, BMS1, ZBTB11, NIP7, PDCD11, PPAN-P2RY11, DHX30, CTCF, NEIL1, IMP4, NSA2, RSBN1, HMGN4, FAM111A, PRKRIR, NOC2L, DDX50, RPF1, GLTSCR2, UTP3, LIN28A, TSPYL1, FGFBP1, C8orf33, CEBPZ, C14orf169, ZNF768, PRPF4B, RPL36AL, SRP68, DDX10, MAGEB2, HIST2H2AB, PPP1R9B, NOL12, RSL24D1, PAK1IP1, ARRB1, MAK16, DDX56, SPRTN, BTF3, FBXW7, UBR5, RCHY1, CCNF, N, SIRT6, RB1CC1,

Top

Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL8	COAD	chr8	146016869	146016869	T	C	Missense_Mutation	p.I98V	3
RPL8	ESCA	chr8	146015317	146015317	G	A	Missense_Mutation	p.H216Y	3
RPL8	COAD	chr8	146015195	146015195	C	A	Missense_Mutation	p.E256D	3
RPL8	SKCM	chr8	146016825	146016825	G	A	Silent	p.I112I	2
RPL8	UCEC	chr8	146015828	146015828	T	C	Missense_Mutation	p.D176G	2
RPL8	HNSC	chr8	146017246	146017246	C	A	Silent	p.R64R	2
RPL8	KICH	chr8	146015277	146015277	G	A	Missense_Mutation	p.A229V	2
RPL8	ESCA	chr8	146017167	146017167	C	T	Missense_Mutation	p.G91S	2
RPL8	STAD	chr8	146017173	146017173	A	G	Missense_Mutation	p.Y89H	2
RPL8	BRCA	chr8	146016828	146016829	-	GG	Frame_Shift_Ins	p.I112fs	2
RPL8	ESCA	chr8	146015317	146015317	G	A	Missense_Mutation		2
RPL8	ESCA	chr8	146015762	146015762	C	A	Missense_Mutation	p.R198L	2
RPL8	STAD	chr8	146015800	146015800	C	T	Silent	p.A185A	2
RPL8	STAD	chr8	146015267	146015267	G	A	Silent	p.G232G	2
RPL8	SKCM	chr8	146017431	146017431	G	C	Silent	p.R28R	2
RPL8	SKCM	chr8	146017189	146017189	G	A	Silent	p.H83H	2
RPL8	SKCM	chr8	146015848	146015848	C	A	Silent	p.V169V	2
RPL8	BLCA	chr8	146015295	146015295	G	T	Missense_Mutation		1
RPL8	LUSC	chr8	146015201	146015201	C	T	Silent	p.E254E	1
RPL8	COAD	chr8	146015856	146015856	C	A	Splice_Site	.	1
RPL8	HNSC	chr8	146015766	146015766	G	A	Missense_Mutation	p.P197S	1
RPL8	BLCA	chr8	146016748	146016748	G	A	Missense_Mutation		1
RPL8	LUSC	chr8	146017203	146017203	C	A	Missense_Mutation	p.A79S	1
RPL8	SKCM	chr8	146017259	146017259	T	G	Missense_Mutation	p.K60T	1
RPL8	BLCA	chr8	146017210	146017210	G	T	Missense_Mutation		1
RPL8	LUSC	chr8	146016768	146016768	C	T	Silent	p.G131G	1
RPL8	COAD	chr8	146017171	146017171	A	G	Silent	p.Y89Y	1
RPL8	SKCM	chr8	146017234	146017234	C	T	Silent	p.R68R	1
RPL8	KICH	chr8	146015277	146015277	G	A	Missense_Mutation		1
RPL8	BLCA	chr8	146015295	146015295	G	T	Missense_Mutation	p.S223Y	1
RPL8	LUSC	chr8	146015194	146015194	T	C	Missense_Mutation	p.N257D	1
RPL8	STAD	chr8	146016765	146016771	GTTCCCT	-	Frame_Shift_Del	p.131_133del	1
RPL8	BLCA	chr8	146016748	146016748	G	A	Missense_Mutation	p.S138F	1
RPL8	LUSC	chr8	146017419	146017419	C	A	Silent	p.V32V	1
RPL8	LIHC	chr8	146016689	146016689	T	A	Missense_Mutation	p.I158F	1
RPL8	OV	chr8	145986010	145986010	G	C	Missense_Mutation	p.Q253E	1
RPL8	STAD	chr8	146015749	146015749	C	A	Silent	p.V202V	1
RPL8	LUAD	chr8	146017270	146017270	C	A	Silent	p.A56A	1
RPL8	CESC	chr8	146016665	146016665	C	A	Missense_Mutation		1
RPL8	PRAD	chr8	146017507	146017507	C	T	Missense_Mutation	p.R3H	1
RPL8	LUAD	chr8	146017200	146017200	C	T	Missense_Mutation	p.E80K	1
RPL8	CESC	chr8	146016665	146016665	C	A	Missense_Mutation	p.V166F	1
RPL8	PRAD	chr8	146015222	146015222	C	A	Silent	p.R247R	1
RPL8	ESCA	chr8	146015762	146015762	C	A	Missense_Mutation		1
RPL8	LUAD	chr8	146017463	146017463	C	T	Missense_Mutation	p.A18T	1
RPL8	CESC	chr8	146015306	146015306	G	A	Silent	p.I219	1
RPL8	HNSC	chr8	146017266	146017266	G	-	Frame_Shift_Del		1
RPL8	STAD	chr8	146016676	146016676	T	C	Missense_Mutation	p.N162S	1
RPL8	LUAD	chr8	146017401	146017401	G	A	Silent	p.H38H	1
RPL8	HNSC	chr8	146017246	146017246	C	A	Silent		1
RPL8	THYM	chr8	146017215	146017215	G	T	Missense_Mutation	p.L75M	1
RPL8	LUAD	chr8	146015223	146015223	C	A	Missense_Mutation	p.R247L	1
RPL8	COAD	chr8	146015299	146015299	G	A	Missense_Mutation	p.P222S	1
RPL8	HNSC	chr8	146015766	146015766	G	A	Missense_Mutation		1
RPL8	THYM	chr8	146017215	146017215	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPL8
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL8
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
91484	Non-Cancer	43N	AAAS	chr12	53702508	-	RPL8	chr8	146015855	-
91484	N/A	EC560160	ARHGAP26	chr5	142409159	+	RPL8	chr8	146016732	-
91484	Non-Cancer	SPNT_369	CRAMP1L	chr16	1716601	+	RPL8	chr8	146015855	-
91484	N/A	BQ330581	DAPK2	chr15	64241232	-	RPL8	chr8	146015787	-
91484	N/A	BM824657	DDX5	chr17	62498626	-	RPL8	chr8	146015205	-
91484	N/A	BP429833	HDAC9	chr7	18458046	-	RPL8	chr8	146015154	+
91484	N/A	AA523041	IFT46	chr11	118419101	+	RPL8	chr8	146015154	+
91484	N/A	BG924889	LBH	chr2	30482430	+	RPL8	chr8	146017524	-
91484	N/A	CV422156	MPZL3	chr11	118097589	-	RPL8	chr8	146015259	+
91484	N/A	BF956598	NRGN	chr11	124616710	-	RPL8	chr8	146017272	-
91484	N/A	BQ681327	NVL	chr1	224514150	-	RPL8	chr8	146016811	-
91484	CESC	TCGA-FU-A23K-01A	PCOLCE2	chr3	142546216	+	RPL8	chr8	146015284	-
91484	LGG	TCGA-HT-A74O-01A	PCOLCE2	chr3	142546199	-	RPL8	chr8	146016682	+
91484	OV	TCGA-09-0367-01A	PCOLCE2	chr3	142546413	-	RPL8	chr8	146017263	+
91484	UCEC	TCGA-EY-A547-01A	PCOLCE2	chr3	142546221	+	RPL8	chr8	146015282	-
91484	N/A	EC487349	PCOLCE2	chr3	142546165	-	RPL8	chr8	146016881	-
91484	N/A	BP306137	PRR13	chr12	53839831	+	RPL8	chr8	146017774	-
91484	N/A	AA523225	RAP1GAP2	chr17	2900926	+	RPL8	chr8	146015152	+
91484	N/A	CB050826	RARB	chr3	25462476	-	RPL8	chr8	146015154	+
91484	N/A	BC015588	RIN2	chr20	19769073	-	RPL8	chr8	146015154	+
86917	PRAD	TCGA-HI-7168-01A	RPL8	chr8	146015154	-	ABCF1	chr6	30545853	+
90092	N/A	CX752756	RPL8	chr8	146015760	-	ACIN1	chr14	23531702	-
101271	UCEC	TCGA-BK-A4ZD-01A	RPL8	chr8	146017395	+	ACTG1	chr17	79479296	-
101271	N/A	BQ949002	RPL8	chr8	146017527	+	ACTG1	chr17	79478365	-
102085	N/A	BI860230	RPL8	chr8	146015154	-	APP	chr21	27473434	-
101692	BLCA	TCGA-GV-A3QI-01A	RPL8	chr8	146016933	-	ARHGAP39	chr8	145871502	-
100994	N/A	AW023919	RPL8	chr8	146015154	-	C16orf47	chr16	73327880	+
99073	N/A	BM014124	RPL8	chr8	146015154	-	CASP8AP2	chr6	90565574	+
92661	OV	TCGA-20-1687-01A	RPL8	chr8	146016822	-	CD74	chr5	149792314	-
85629	N/A	T11639	RPL8	chr8	146015154	-	CDC42BPA	chr1	227200913	+
94750	LUAD	TCGA-95-A4VN-01A	RPL8	chr8	146015155	-	CFB	chr6	31913427	+
101209	N/A	EC575685	RPL8	chr8	146016660	-	COL14A1	chr8	121270714	+
102173	BLCA	TCGA-FD-A3SQ-01A	RPL8	chr8	146015278	-	COL1A1	chr17	48261577	-
84637	Non-Cancer	TCGA-HU-A4GP-11A	RPL8	chr8	146015193	-	CPE	chr4	166408675	+
102507	STAD	TCGA-BR-8591-01A	RPL8	chr8	146015155	-	DDX21	chr10	70723858	+
100903	N/A	BI857246	RPL8	chr8	146015155	-	DNAH8	chr6	38807162	-
77062	COAD	TCGA-AZ-4681-01A	RPL8	chr8	146015780	-	EFS	chr14	23828978	-
99835	READ	TCGA-AG-3605	RPL8	chr8	146015757	-	ETV5	chr3	185826703	-
96299	STAD	TCGA-BR-8077-01A	RPL8	chr8	146017377	-	FAF1	chr1	51061888	-
95894	SKCM	TCGA-EE-A29Q-06A	RPL8	chr8	146015154	-	FMN1	chr15	33096533	-
100997	SKCM	TCGA-EE-A2MT-06A	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
92918	N/A	AI638676	RPL8	chr8	146015279	+	KIRREL	chr1	158069421	-
94447	HNSC	TCGA-CV-7416	RPL8	chr8	146015274	-	KRT13	chr17	39657474	-
77062	N/A	AA523054	RPL8	chr8	146015154	-	LINC00431	chr13	111629546	-
96577	N/A	BG029949	RPL8	chr8	146015154	-	MUC12	chr7	100614443	+
98948	BRCA	TCGA-D8-A1XS-01A	RPL8	chr8	146015155	-	NDUFV1	chr11	67375697	+
82954	LGG	TCGA-CS-5393-01A	RPL8	chr8	146015155	-	NOVA1	chr14	27066692	-
77062	N/A	BI860266	RPL8	chr8	146015154	-	POLQ	chr3	121217168	+
101173	N/A	BG575269	RPL8	chr8	146015154	-	RAD51B	chr14	68837701	+
93096	N/A	CB050827	RPL8	chr8	146015154	-	RARB	chr3	25462476	+
82562	PRAD	TCGA-EJ-5512-01A	RPL8	chr8	146015154	-	SCARB1	chr12	125324217	-
92257	SARC	TCGA-DX-A8BP-01A	RPL8	chr8	146015155	-	SLC1A3	chr5	36606541	+
102406	BRCA	TCGA-E9-A1RE-01A	RPL8	chr8	146015155	-	SNW1	chr14	78189203	-
100748	COAD	TCGA-AZ-4308-01A	RPL8	chr8	146017187	-	SYNJ2	chr6	158514057	+
91280	N/A	CV366110	RPL8	chr8	146015323	-	TM9SF4	chr20	30729302	+
102496	N/A	BD309704	RPL8	chr8	146015154	-	UBE2L3	chr22	21920043	+
100715	N/A	AA522562	RPL8	chr8	146015152	-	UBE2R2	chr9	33879772	-
91485	N/A	EC563838	TMED9	chr5	177023032	-	RPL8	chr8	146015215	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPL8	0.00488728032553225	0.14
KIRC	RPL8	0.00869767546808195	0.23
TGCT	RPL8	0.0343712469066451	0.89
SARC	RPL8	0.0416619126403495	1

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL8	0.00107117966924114	0.035
PRAD	RPL8	0.0386090404714205	1
PAAD	RPL8	0.0316524174144728	0.98
OV	RPL8	0.0118106601806411	0.38

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source