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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL11 (NCBI Gene ID:6135)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL11
	Gene ID: 6135
	Gene Symbol	RPL11
	Gene ID	6135
	Gene Name	ribosomal protein L11
	Synonyms	DBA7\|GIG34\|L11\|uL5
	Cytomap	1p36.11
	Type of Gene	protein-coding
	Description	60S ribosomal protein L11CLL-associated antigen KW-12cell growth-inhibiting protein 34large ribosomal subunit protein uL5
	Modification date	20200327
	UniProtAcc	P62913

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL11	GO:0002181	cytoplasmic translation	25957688
Hgene	RPL11	GO:0010628	positive regulation of gene expression	18560357
Hgene	RPL11	GO:2000435	negative regulation of protein neddylation	18560357

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL11	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL11[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL11	Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity	24061479

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	RPL11	-5.47536848868151	6.13619476098216e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UVM	RPL11	-0.187225278	0.000203145
SARC	RPL11	-0.122862782	0.019352662

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL11 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL11	PFDN5	0.826071293	4.90E-13
DLBC	Cell metabolism gene	RPL11	SNRPD2	0.835041619	1.61E-13
DLBC	Cell metabolism gene	RPL11	FAU	0.843684601	5.14E-14
DLBC	CGC	RPL11	NACA	0.835959105	1.43E-13
DLBC	TSG	RPL11	GNB2L1	0.855018473	1.04E-14
KICH	TSG	RPL11	GAS5	0.807618321	4.01E-22
KIRP	Cell metabolism gene	RPL11	FAU	0.815237102	3.86E-78
LGG	Epifactor	RPL11	FBL	0.858118298	5.63E-155
PRAD	Cell metabolism gene	RPL11	TOMM7	0.814388597	1.29E-131
PRAD	Cell metabolism gene	RPL11	SNRPD2	0.832267719	1.64E-142
PRAD	Cell metabolism gene	RPL11	FAU	0.844620309	8.05E-151
PRAD	CGC	RPL11	NACA	0.843116855	9.03E-150
PRAD	Epifactor	RPL11	FBL	0.867968003	1.03E-168
PRAD	TSG	RPL11	GLTSCR2	0.802013431	9.63E-125
PRAD	TSG	RPL11	GAS5	0.802539477	5.03E-125
PRAD	TSG	RPL11	GNB2L1	0.863350635	6.50E-165
THCA	Cell metabolism gene	RPL11	SNRPD2	0.840394965	9.27E-154
THCA	Cell metabolism gene	RPL11	FAU	0.861377181	8.20E-170
THCA	Cell metabolism gene	RPL11	PFDN5	0.876010713	1.17E-182
THCA	CGC	RPL11	NACA	0.825263747	1.46E-143
THCA	Epifactor	RPL11	FBL	0.843521674	5.33E-156
THCA	TSG	RPL11	GNB2L1	0.814442086	7.43E-137
THYM	Cell metabolism gene	RPL11	POLR2I	0.803466885	8.46E-29
THYM	Cell metabolism gene	RPL11	SSR2	0.803576706	8.21E-29
THYM	Cell metabolism gene	RPL11	PSMC3	0.806159928	4.03E-29
THYM	Cell metabolism gene	RPL11	TIMM13	0.806894769	3.28E-29
THYM	Cell metabolism gene	RPL11	POLR2J	0.808337698	2.19E-29
THYM	Cell metabolism gene	RPL11	SLC27A5	0.813554244	4.95E-30
THYM	Cell metabolism gene	RPL11	TIMM8B	0.820958145	5.50E-31
THYM	Cell metabolism gene	RPL11	POLR2F	0.821041763	5.37E-31
THYM	Cell metabolism gene	RPL11	UROD	0.821188834	5.13E-31
THYM	Cell metabolism gene	RPL11	IDH3G	0.826787044	9.09E-32
THYM	Cell metabolism gene	RPL11	PSMB7	0.829508211	3.83E-32
THYM	Cell metabolism gene	RPL11	DPM2	0.830963935	2.40E-32
THYM	Cell metabolism gene	RPL11	SNRPD3	0.831148471	2.26E-32
THYM	Cell metabolism gene	RPL11	APRT	0.831350422	2.12E-32
THYM	Cell metabolism gene	RPL11	SNRPD2	0.83975411	1.28E-33
THYM	Cell metabolism gene	RPL11	PGLS	0.843798759	3.15E-34
THYM	Cell metabolism gene	RPL11	PFDN5	0.851102488	2.23E-35
THYM	Cell metabolism gene	RPL11	FAU	0.899487611	5.73E-45
THYM	CGC	RPL11	TFPT	0.80119465	1.57E-28
THYM	Epifactor	RPL11	TFPT	0.80119465	1.57E-28
THYM	Epifactor	RPL11	SIRT6	0.803319234	8.80E-29
THYM	Epifactor	RPL11	INO80E	0.808564649	2.06E-29
THYM	Epifactor	RPL11	BRMS1	0.81099026	1.03E-29
THYM	Epifactor	RPL11	PRPF31	0.825847772	1.22E-31
THYM	Epifactor	RPL11	C17orf49	0.829098985	4.37E-32
THYM	Epifactor	RPL11	DMAP1	0.830908629	2.44E-32
THYM	Epifactor	RPL11	FBL	0.834696926	7.06E-33
THYM	Epifactor	RPL11	ZNHIT1	0.834818984	6.78E-33
THYM	Epifactor	RPL11	TAF10	0.84476895	2.23E-34
THYM	IUPHAR	RPL11	SIRT6	0.803319234	8.80E-29
THYM	IUPHAR	RPL11	SLC27A5	0.813554244	4.95E-30
THYM	TF	RPL11	THAP7	0.801144954	1.59E-28
THYM	TF	RPL11	THYN1	0.820427744	6.46E-31
THYM	TF	RPL11	THAP3	0.825782668	1.25E-31
THYM	TF	RPL11	ZNF428	0.826832532	8.96E-32
THYM	TSG	RPL11	GABARAP	0.800158728	2.07E-28
THYM	TSG	RPL11	SIRT6	0.803319234	8.80E-29
THYM	TSG	RPL11	TSSC4	0.805542563	4.78E-29
THYM	TSG	RPL11	BRMS1	0.81099026	1.03E-29
THYM	TSG	RPL11	PARK7	0.828563645	5.18E-32
THYM	TSG	RPL11	GLTSCR2	0.869412584	1.50E-38
THYM	TSG	RPL11	GNB2L1	0.889741659	1.10E-42
UCS	Cell metabolism gene	RPL11	POLR2I	0.803466885	8.46E-29
UCS	Cell metabolism gene	RPL11	SSR2	0.803576706	8.21E-29
UCS	Cell metabolism gene	RPL11	PSMC3	0.806159928	4.03E-29
UCS	Cell metabolism gene	RPL11	TIMM13	0.806894769	3.28E-29
UCS	Cell metabolism gene	RPL11	POLR2J	0.808337698	2.19E-29
UCS	Cell metabolism gene	RPL11	SLC27A5	0.813554244	4.95E-30
UCS	Cell metabolism gene	RPL11	TIMM8B	0.820958145	5.50E-31
UCS	Cell metabolism gene	RPL11	POLR2F	0.821041763	5.37E-31
UCS	Cell metabolism gene	RPL11	UROD	0.821188834	5.13E-31
UCS	Cell metabolism gene	RPL11	IDH3G	0.826787044	9.09E-32
UCS	Cell metabolism gene	RPL11	PSMB7	0.829508211	3.83E-32
UCS	Cell metabolism gene	RPL11	DPM2	0.830963935	2.40E-32
UCS	Cell metabolism gene	RPL11	SNRPD3	0.831148471	2.26E-32
UCS	Cell metabolism gene	RPL11	APRT	0.831350422	2.12E-32
UCS	Cell metabolism gene	RPL11	SNRPD2	0.83975411	1.28E-33
UCS	Cell metabolism gene	RPL11	PGLS	0.843798759	3.15E-34
UCS	Cell metabolism gene	RPL11	PFDN5	0.851102488	2.23E-35
UCS	Cell metabolism gene	RPL11	FAU	0.899487611	5.73E-45
UCS	CGC	RPL11	TFPT	0.80119465	1.57E-28
UCS	Epifactor	RPL11	TFPT	0.80119465	1.57E-28
UCS	Epifactor	RPL11	SIRT6	0.803319234	8.80E-29
UCS	Epifactor	RPL11	INO80E	0.808564649	2.06E-29
UCS	Epifactor	RPL11	BRMS1	0.81099026	1.03E-29
UCS	Epifactor	RPL11	PRPF31	0.825847772	1.22E-31
UCS	Epifactor	RPL11	C17orf49	0.829098985	4.37E-32
UCS	Epifactor	RPL11	DMAP1	0.830908629	2.44E-32
UCS	Epifactor	RPL11	FBL	0.834696926	7.06E-33
UCS	Epifactor	RPL11	ZNHIT1	0.834818984	6.78E-33
UCS	Epifactor	RPL11	TAF10	0.84476895	2.23E-34
UCS	IUPHAR	RPL11	SIRT6	0.803319234	8.80E-29
UCS	IUPHAR	RPL11	SLC27A5	0.813554244	4.95E-30
UCS	TF	RPL11	THAP7	0.801144954	1.59E-28
UCS	TF	RPL11	THYN1	0.820427744	6.46E-31
UCS	TF	RPL11	THAP3	0.825782668	1.25E-31
UCS	TF	RPL11	ZNF428	0.826832532	8.96E-32
UCS	TSG	RPL11	GABARAP	0.800158728	2.07E-28
UCS	TSG	RPL11	SIRT6	0.803319234	8.80E-29
UCS	TSG	RPL11	TSSC4	0.805542563	4.78E-29
UCS	TSG	RPL11	BRMS1	0.81099026	1.03E-29
UCS	TSG	RPL11	PARK7	0.828563645	5.18E-32
UCS	TSG	RPL11	GLTSCR2	0.869412584	1.50E-38
UCS	TSG	RPL11	GNB2L1	0.889741659	1.10E-42

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL11	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL11	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL11	RPS16	-1.35957043617517	0.00019507110118866
KIRP	RPL11	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL11	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL11	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL11	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL11	RPS12	1.26997381758431	0.00308787822723389
LIHC	RPL11	MDM2	-1.57082310333019	0.00323738381247511
LUAD	RPL11	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL11	RPS16	-6.16322798156577	0.0115764821363307
STAD	RPL11	MDM2	-1.99312650485559	0.0132303284481168
BLCA	RPL11	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL11	RPS27A	-1.04747470069188	0.0258216857910156
COAD	RPL11	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL11	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL11	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL11	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL11	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL11	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL11	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL11	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL11	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL11	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL11	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL11	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL11	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL11

PML, MDM2, CDKN2A, TP53, BLMH, RPL23, RPL5, MYC, AGO4, NOP56, EBNA-LP, RAD21, ARRB2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPL10A, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL24, RPL27A, RPL31, RPL37A, RPL6, RPL7A, RPL7, RPL9, RPS11, RPS12, RPS13, RPS14, RPS15A, RPS16, RPS20, RPS23, RPS24, RPS25, RPS28, RPS2, RPS3, RPS4X, RPS6, RPS8, RPSA, RPL30, RPS3A, RPS5, RPS19, RPL4, RPS7, RPL22, RPS26, RPLP1, RPL36, RPL8, RPLP0, RPL3, RPS9, RPL10, RPL35, RPS10, RPL38, RPL17, RPS21, EEF1A1, RPS27A, EEF2, GNL3, FBL, ILF3, ILF2, SLC25A5, NCL, NHP2L1, TUFM, HNRNPM, NOP58, NAP1L1, NOLC1, RPS27L, NOP2, MRPL12, BTF3, ANXA2, RPL10L, RPLP0P6, RRS1, NIFK, UQCRB, NEMF, UPF1, RBM8A, ESR1, LIG4, FMNL1, PA2G4, FN1, VCAM1, UBL4A, ITGA4, PELP1, VHL, PAN2, CD81, IGSF8, ICAM1, MYEOV2, ARFGAP1, PAIP2, STAT3, HP, IGF1R, C12orf5, TARDBP, QRICH1, ZBTB1, AURKA, CEP57, CEP250, TUBGCP2, TUBGCP3, FUS, CAMK2B, KRT40, KRTAP10-7, CUL7, OBSL1, CCDC8, EED, SURF2, BRIX1, FAU, MRPL24, MRPS10, MRPS7, PAK1IP1, DDX18, DDX24, EBNA1BP2, KPNA6, KRR1, PABPC1, POLR1B, RPL13A, RPL27, RPLP2, RPS15, RPL32, RPL35A, RPL3L, RPS18, LOC101929876, RPS27, APP, HSPB2, gag, AHSA1, HNRNPU, NPM1, Eif3a, Eif3e, Rpl35, Srp72, Naa50, Rrbp1, Brwd3, TP73, MCM2, Mdm2, ZNF618, RC3H1, GRWD1, CDC73, CHIT1, CNBP, ALDH2, TUBA1A, CYLD, INO80B, TRIM25, HEY1, BRCA1, LMNA, MTF1, ARL2, BDP1, DCTN4, DUT, EIF4G2, LEO1, PSMD4, SNAPC1, UBA2, ZNHIT6, FBXO7, GLTSCR2, PCBP1, ACO2, API5, BMP4, CTNNB1, GSK3A, TGFB1, YAF2, YAP1, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, LARP7, TNF, SPDL1, RIOK1, HEXIM1, MEPCE, RNF123, SNAI1, AGR2, RECQL4, WWP1, GPC1, REST, ZFP36L2, ATM, Prkaa1, Prkab1, RPS6KB2, SENP1, UBE2I, METTL14, RC3H2, PHB, RBX1, USP14, NR2C2, PPP1CC, CTCF, KRAS, VRK1, VRK3, HIST1H4A, SNRNP70, ITFG1, ARAF, HMGB1, PPP1CA, STAU1, NFX1, WWP2, SOX2, PARK2, CMTR1, OSBPL3, DVL3, IP6K1, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, HCVgp1, PCAT1, ZC3H18, PTPN6, MED6, TIPARP, SNIP1, M, nsp4, nsp6, ORF7a, MAP1LC3B, SMC1A, SMC3, STAG2, WAPAL, MAU2, CPEB4, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, FASN, LRRC59, INS, NDN, Rnf183, BRD4, NINL, RBM45, Apc2, RBM39, FBP1, RIN3, OGT, SPOP, UFL1, DDRGK1, DHFRL1, TRIM37, ATG3, FZR1, PAGE4, NUDCD2, NAA40, ZBTB2, GLYR1, GLE1, ZNF771, ADARB1, NVL, NMNAT1, REPIN1, DDX21, SURF6, FTSJ3, GZF1, HEATR3, KIAA0020, MDM4, RBM34, CENPU, RPL36AL, WHSC1, ZNF184, NOC3L, DDX31, ZNF888, RPL28, HIST2H2BF, ZCCHC7, ZNF689, PAPD5, ZNF354A, ZBTB10, ZNF48, TAF1D, GNL2, HP1BP3, NSA2, GTPBP4, PPAN-P2RY11, USP42, RSL24D1, RBM28, PRDM15, ZNF770, ZNF668, UTP23, TTF1, RRP8, ZNF724P, DDX27, AATF, MAGEB2, KBTBD6, NIP7, HIST1H1E, NOC2L, DKC1, NKRF, SDAD1, RBMX2, LYAR, KNOP1, RPL7L1, DDX54, DDX56, RPL26, RSL1D1, ZC3HAV1, LUC7L, HIST1H1T, RPL26L1, PRPF4B, ZNF512, RRP1B, BMS1, EPB41L5, SRPK2, SRP72, FAM111A, IMP3, NOM1, RNH1, WDR74, GAR1, ZNF768, BUD13, RSBN1, UTP3, NOL12, SRP68, PRKRA, CEBPZ, DDX50, TRIP12, FCF1, ABT1, NPM3, IMP4, CCDC137, TRIM56, PBRM1, DHX30, DDX51, NGDN, NOP16, C1orf35, EPB41L4B, NEIL1, RPF2, ZNF346, SRSF5, DDX10, C8orf33, C7orf50, CDC5L, ZBTB11, ZNF574, GPATCH4, BOP1, ZFR, RRP15, MYBBP1A, CCDC59, TAF1C, HIST2H2AB, RPF1, CCDC86, MAK16, LIN28A, MPHOSPH10, SPRTN, FBXW7, NLRP7, nsp1, RCHY1, CCNF, N, PSMD9, PIGR,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL11	chr1	24018205	C	T	single_nucleotide_variant	Benign	not_provided
RPL11	chr1	24018224	C	T	single_nucleotide_variant	Benign	not_provided
RPL11	chr1	24018277	C	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPL11	chr1	24018300	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_7	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPL11	chr1	24018317	G	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24018318	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24018327	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24018338	G	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24018369	G	T	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24018387	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24018953	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24018965	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24018999	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24019079	G	T	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24019089	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24019098	G	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001574\|splice_acceptor_variant,SO:0001627\|intron_variant	SO:0001574\|splice_acceptor_variant,SO:0001627\|intron_variant
RPL11	chr1	24019106	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24019116	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24019122	C	T	single_nucleotide_variant	Benign/Likely_benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24019125	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24019133	AACTTCGC	A	Deletion	Pathogenic	Diamond-Blackfan_anemia_7	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019149	ACT	A	Microsatellite	Pathogenic	Diamond-Blackfan_anemia_7	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019152	CTG	C	Deletion	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019194	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24019194	G	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24019198	GC	G	Deletion	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019201	GC	G	Deletion	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019207	G	GT	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019209	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24019213	G	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001587\|nonsense	SO:0001587\|nonsense
RPL11	chr1	24019231	A	ACC	Duplication	Likely_pathogenic	Reticulocytopenia\|Anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019234	CCT	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24019245	C	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24020290	C	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24020290	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_7	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24020296	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPL11	chr1	24020298	T	TA	Duplication	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24020310	C	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24020328	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24020341	AT	A	Deletion	Pathogenic	Diamond-Blackfan_anemia_7	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24020342	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24020362	C	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPL11	chr1	24020363	G	A	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24020397	T	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24020404	G	A	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPL11	chr1	24020412	A	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_7	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24020470	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24021154	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24021155	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_7	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24021172	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_7	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24021178	ACTT	A	Deletion	Uncertain_significance	not_specified	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPL11	chr1	24021182	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24021185	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24021191	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24021224	C	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24021228	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL11	chr1	24021290	A	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24021403	TCTC	T	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24022284	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24022286	A	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPL11	chr1	24022334	C	CAG	Duplication	Uncertain_significance	not_specified	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24022343	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24022345	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL11	chr1	24022352	AAC	A	Microsatellite	Pathogenic	Diamond-Blackfan_anemia_7	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24022365	CAA	C	Deletion	Pathogenic	Diamond-Blackfan_anemia_7	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPL11	chr1	24022368	AGAG	A	Microsatellite	Pathogenic	Diamond-Blackfan_anemia_7	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPL11	chr1	24022437	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL11	chr1	24022832	A	G	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_7	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPL11	chr1	24022915	A	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_7\|not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPL11	chr1	24023011	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL11	LUAD	chr1	24021184	24021184	C	T	Missense_Mutation	p.S100L	7
RPL11	KIRP	chr1	24021204	24021204	T	G	Missense_Mutation	p.F107V	4
RPL11	ESCA	chr1	24019129	24019129	C	T	Missense_Mutation	p.R13W	3
RPL11	LIHC	chr1	24022368	24022368	A	G	Silent	p.K159K	3
RPL11	COAD	chr1	24022315	24022315	G	A	Missense_Mutation	p.A142T	3
RPL11	ESCA	chr1	24019156	24019156	C	G	Missense_Mutation	p.L22V	3
RPL11	ESCA	chr1	24019156	24019156	C	G	Missense_Mutation		2
RPL11	SKCM	chr1	24020315	24020315	C	T	Missense_Mutation	p.S59F	2
RPL11	BLCA	chr1	24019138	24019138	C	T	Missense_Mutation	p.R16C	2
RPL11	ESCA	chr1	24021225	24021225	G	T	Missense_Mutation		2
RPL11	SKCM	chr1	24019189	24019189	C	A	Missense_Mutation	p.L33M	2
RPL11	UVM	chr1	24019228	24019229	-	AG	Frame_Shift_Ins	p.Q46fs	2
RPL11	BLCA	chr1	24021260	24021260	C	G	Missense_Mutation	p.I125M	2
RPL11	PRAD	chr1	24019135	24019135	C	T	Missense_Mutation	p.L15F	2
RPL11	BLCA	chr1	24021182	24021182	C	T	Silent	p.F99F	2
RPL11	GBM	chr1	24018320	24018320	G	C	Splice_Site	p.A2_splice	2
RPL11	PRAD	chr1	24020353	24020353	T	C	Missense_Mutation	p.C72R	2
RPL11	UCEC	chr1	24022328	24022328	G	A	Missense_Mutation	p.R146H	2
RPL11	SARC	chr1	24018316	24018331	GGCGGTGAGTAGCTGG	-	Splice_Site		2
RPL11	UCEC	chr1	24022839	24022839	T	C	Silent	p.D171	2
RPL11	KIRP	chr1	24021148	24021148	A	T	Splice_Site		1
RPL11	UVM	chr1	24019228	24019229	-	-	Frame_Shift_Ins		1
RPL11	PAAD	chr1	24022341	24022341	C	A	Nonsense_Mutation	p.C150*	1
RPL11	KIRP	chr1	24021204	24021204	T	G	Missense_Mutation		1
RPL11	SKCM	chr1	24021238	24021238	A	C	Missense_Mutation	p.K118T	1
RPL11	KIRP	chr1	24022841	24022841	G	T	Missense_Mutation		1
RPL11	UVM	chr1	24019228	24019229	-	AG	Frame_Shift_Ins	p.D46fs	1
RPL11	PRAD	chr1	24021277	24021277	A	G	Missense_Mutation	p.Y131C	1
RPL11	SKCM	chr1	24022390	24022390	C	T	Nonsense_Mutation	p.Q167*	1
RPL11	LIHC	chr1	24022333	24022333	A	G	Missense_Mutation		1
RPL11	BLCA	chr1	24020391	24020391	G	A	Silent	p.E84E	1
RPL11	GBM	chr1	24019182	24019185	AGAC	-	Frame_Shift_Del	p.G30fs	1
RPL11	SKCM	chr1	24022389	24022389	C	T	Silent	p.F166F	1
RPL11	BLCA	chr1	24020313	24020313	A	G	Silent	p.R58R	1
RPL11	PRAD	chr1	24019112	24019112	A	-	Frame_Shift_Del	p.E7fs	1
RPL11	HNSC	chr1	24019119	24019119	G	A	Silent		1
RPL11	STAD	chr1	24018320	24018320	G	T	Splice_Site	.	1
RPL11	BLCA	chr1	24019138	24019138	C	T	Missense_Mutation		1
RPL11	LIHC	chr1	24022333	24022333	A	G	Missense_Mutation	p.T148A	1
RPL11	CESC	chr1	24022845	24022845	C	T	Silent		1
RPL11	READ	chr1	24021271	24021271	A	T	Missense_Mutation	p.D129V	1
RPL11	HNSC	chr1	24019119	24019119	G	A	Silent	p.E9E	1
RPL11	THCA	chr1	24021247	24021247	C	A	Missense_Mutation		1
RPL11	BLCA	chr1	24021182	24021182	C	T	Silent		1
RPL11	LIHC	chr1	24022327	24022327	C	T	Missense_Mutation	p.R146C	1
RPL11	CESC	chr1	24022845	24022845	C	T	Silent	p.I173	1
RPL11	READ	chr1	24022387	24022387	T	C	Missense_Mutation	p.F166L	1
RPL11	KICH	chr1	24021261	24021261	T	-	Frame_Shift_Del		1
RPL11	THYM	chr1	24019235	24019235	C	G	Missense_Mutation	p.P48R	1
RPL11	BLCA	chr1	24021260	24021260	C	G	Missense_Mutation		1
RPL11	LIHC	chr1	24020395	24020395	G	T	Missense_Mutation	p.G86C	1
RPL11	READ	chr1	24022845	24022845	C	T	Silent	p.I173I	1
RPL11	KICH	chr1	24021261	24021261	T	-	Frame_Shift_Del	p.I125fs	1
RPL11	UCEC	chr1	24021169	24021170	-	A	Frame_Shift_Ins	p.R95fs	1
RPL11	BLCA	chr1	24020313	24020313	A	G	Silent		1
RPL11	LUAD	chr1	24021209	24021209	G	T	Silent	p.G108G	1
RPL11	SARC	chr1	24021265	24021265	G	T	Missense_Mutation		1
RPL11	KIRC	chr1	24022342	24022342	A	T	Missense_Mutation	p.I151F	1
RPL11	BLCA	chr1	24018290	24018290	C	T	Missense_Mutation		1
RPL11	ESCA	chr1	24021225	24021225	G	T	Missense_Mutation	p.D114Y	1
RPL11	BLCA	chr1	24019102	24019102	G	A	Missense_Mutation		1
RPL11	LUAD	chr1	24021163	24021163	A	T	Missense_Mutation	p.E93V	1

Copy number variation (CNV) of RPL11
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL11
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97188	N/A	AA076379	AC006460.2	chr2	191507719	+	RPL11	chr1	24022908	-
97188	N/A	AA650167	AC006460.2	chr2	191507718	+	RPL11	chr1	24022908	-
97188	N/A	CV387556	ADAMTS2	chr5	178701856	-	RPL11	chr1	24018296	+
97188	N/A	BI496666	ADNP	chr20	49506660	-	RPL11	chr1	24022904	-
97188	N/A	BI491968	CASC1	chr12	25328617	+	RPL11	chr1	24022908	-
97188	N/A	AU100496	FRYL	chr4	48531069	+	RPL11	chr1	24019132	+
97188	N/A	BG030720	KPNB1	chr17	45761891	-	RPL11	chr1	24021242	+
97188	N/A	BU598868	NAA50	chr3	113442278	-	RPL11	chr1	24022297	+
97188	READ	TCGA-AG-3882	NAIP	chr5	70281590	-	RPL11	chr1	24019101	+
97188	BRCA	TCGA-E2-A1LS-01A	PTEN	chr10	89705770	+	RPL11	chr1	24022859	+
97188	CESC	TCGA-EA-A3HU-01A	PTEN	chr10	89705654	+	RPL11	chr1	24021153	+
97188	KIRC	TCGA-A3-3382-01A	PTEN	chr10	89705653	+	RPL11	chr1	24021205	+
97188	LAML	TCGA-AB-2854-03A	PTEN	chr10	89705770	+	RPL11	chr1	24022324	+
97188	PRAD	TCGA-EJ-5512-01A	PTEN	chr10	89705655	+	RPL11	chr1	24021153	+
97188	N/A	AA420671	RGS6	chr14	72680908	+	RPL11	chr1	24022908	-
75840	N/A	AA522625	RPL11	chr1	24022908	+	AC006460.2	chr2	191507719	-
80097	N/A	BG031525	RPL11	chr1	24022908	+	AGMO	chr7	15175632	-
75840	SARC	TCGA-DX-A8BX-01A	RPL11	chr1	24021281	+	ARMC9	chr2	232225466	+
75840	N/A	BG033694	RPL11	chr1	24022908	+	C11orf40	chr11	4596738	+
75840	N/A	CD240152	RPL11	chr1	24022908	+	C1S	chr12	7169581	+
99549	BRCA	TCGA-D8-A1XZ-01A	RPL11	chr1	24022398	+	CAMTA1	chr1	7805905	+
92198	N/A	BE613010	RPL11	chr1	24020323	-	EPHX1	chr1	226027547	+
101363	N/A	BG033299	RPL11	chr1	24022915	+	FAM189A1	chr15	29815797	-
95950	N/A	AV693175	RPL11	chr1	24022915	+	GRIK4	chr11	120856328	+
75840	N/A	AA447363	RPL11	chr1	24022300	-	KDM5C	chrX	53222271	+
82058	N/A	BG575204	RPL11	chr1	24022915	+	MORF4L1	chr15	79153896	-
75840	N/A	CB409379	RPL11	chr1	24022397	+	NDUFB4	chr3	120321083	+
95332	N/A	BF218124	RPL11	chr1	24022883	+	PAQR5	chr15	69577797	+
102311	N/A	BM013660	RPL11	chr1	24022908	+	PARD3	chr10	34685269	+
98891	UCEC	TCGA-AP-A054-01A	RPL11	chr1	24020403	+	PDE6A	chr5	149246797	-
75840	UCS	TCGA-ND-A4WC-01A	RPL11	chr1	24020403	+	PNRC2	chr1	24287419	+
95629	N/A	BI858658	RPL11	chr1	24022908	+	PRR5-ARHGAP8	chr22	45168133	-
98789	N/A	EC486423	RPL11	chr1	24022398	+	PTEN	chr10	89705718	+
95238	N/A	AA523674	RPL11	chr1	24022908	+	RNF138	chr18	29674180	-
97188	N/A	AA876625	RPL11	chr1	24022330	+	RPL11	chr1	24022384	-
97188	N/A	BQ310852	RPL11	chr1	24019146	-	RPL11	chr1	24022354	-
98682	UCEC	TCGA-AJ-A3EJ-01A	RPL11	chr1	24022915	-	SIAE	chr11	124543777	-
75840	N/A	AU134575	RPL11	chr1	24022367	+	STRN4	chr19	47228158	-
101954	N/A	BP280989	RPL11	chr1	24021281	+	TCEB3	chr1	24075511	+
97303	N/A	CD388242	RPL11	chr1	24020406	+	TKT	chr3	53259752	-
75840	N/A	CN269184	RPL11	chr1	24022336	+	TMCO6	chr5	140021281	+
75840	STAD	TCGA-BR-8676-01A	RPL11	chr1	24022908	+	ZNF747	chr16	30542803	-
97188	STAD	TCGA-IN-7808-01A	SF3B2	chr11	65828202	+	RPL11	chr1	24022288	+
97188	Non-Cancer	131Nd	SNHG1	chr11	62622895	-	RPL11	chr1	24022287	+
97188	N/A	BE044946	SUN2	chr22	39159587	+	RPL11	chr1	24022908	-
97188	N/A	BG272717	THADA	chr2	43731343	+	RPL11	chr1	24022912	-
97189	N/A	AA483472	USP12	chr13	27727077	-	RPL11	chr1	24022904	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPL11	0.00730598665757407	0.2
BRCA	RPL11	0.0195653356260141	0.53

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	RPL11	0.00335955529948194	0.11
BRCA	RPL11	0.000328302873351686	0.011

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P62913	DB02494	(S)-3-phenyllactic acid		Small molecule	Experimental
P62913	DB07374	Anisomycin		Small molecule	Experimental
P62913	DB08437	Puromycin		Small molecule	Experimental
P62913	DB02494	(S)-3-phenyllactic acid
P62913	DB07374	Anisomycin
P62913	DB08437	Puromycin

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	4	GENOMICS_ENGLAND
C2675512	Diamond-Blackfan Anemia 7	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
C0431890	Hypoplasia of thumb	2	GENOMICS_ENGLAND
C0376358	Malignant neoplasm of prostate	1	CTD_human