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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL19 (NCBI Gene ID:6143)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL19
	Gene ID: 6143
	Gene Symbol	RPL19
	Gene ID	6143
	Gene Name	ribosomal protein L19
	Synonyms	L19
	Cytomap	17q12
	Type of Gene	protein-coding
	Description	60S ribosomal protein L19large ribosomal subunit protein eL19
	Modification date	20200313
	UniProtAcc	P84098

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL19	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL19	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL19[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL19	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000225430	37358569	37358692	In-frame
ENST00000225430	37359241	37359362	Frame-shift
ENST00000225430	37360329	37360440	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000225430	37358569	37358692	749	175	297	196	37	78
ENST00000225430	37360329	37360440	749	419	529	196	119	155

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P84098	119	155	1	196	Chain	ID=PRO_0000131169;Note=60S ribosomal protein L19
P84098	37	78	1	196	Chain	ID=PRO_0000131169;Note=60S ribosomal protein L19
P84098	37	78	38	38	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	RPL19	1.36901182894089	0.00250792503356934
LUAD	RPL19	-1.31398026615725	0.00993159558412698
LUSC	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL19	-2.73485271276676	1.33980982873695e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
MESO	RPL19	1	2	0.0212344849557325	0.184754437869822	0.227699792099792	-0.189392074792377	0.506594203793632

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
CESC	RPL19	1	2	0.0143031188816401	0.164999	0.276581357615894	-0.5308607842379	-0.0592655524490985
DLBC	RPL19	1	2	0.0296673366854866	0.160484848484849	0.244985897435898	-1.21734442060309	-0.995069245776846
THYM	RPL19	1	2	0.0410004528574362	0.185899507389163	0.219073319327731	-0.145701473892269	-0.0336381371782616

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	RPL19	0.127861609	0.023331786
KICH	RPL19	0.01996991	0.042866181

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL19 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	RPL19	NACA	0.817449058	7.31E-12
CHOL	Epifactor	RPL19	FBL	0.805661329	2.47E-11
CHOL	TSG	RPL19	GNB2L1	0.842719608	3.88E-13
DLBC	Cell metabolism gene	RPL19	TIMM13	0.803986469	5.94E-12
DLBC	Cell metabolism gene	RPL19	TOMM22	0.805678307	4.97E-12
DLBC	Cell metabolism gene	RPL19	POLR2F	0.812050386	2.48E-12
DLBC	Cell metabolism gene	RPL19	GEMIN7	0.821817108	8.14E-13
DLBC	Cell metabolism gene	RPL19	PFDN5	0.846880631	3.32E-14
DLBC	Cell metabolism gene	RPL19	SNRPD2	0.856929709	7.80E-15
DLBC	Cell metabolism gene	RPL19	TIMM9	0.871803488	7.38E-16
DLBC	Cell metabolism gene	RPL19	NME2	0.881762395	1.28E-16
DLBC	Cell metabolism gene	RPL19	FAU	0.889394417	3.01E-17
DLBC	CGC	RPL19	NACA	0.883550302	9.23E-17
DLBC	Epifactor	RPL19	FBL	0.848844478	2.52E-14
DLBC	TF	RPL19	ZNF581	0.862941809	3.11E-15
DLBC	TF	RPL19	NME2	0.881762395	1.28E-16
DLBC	TSG	RPL19	GADD45GIP1	0.811678732	2.59E-12
DLBC	TSG	RPL19	GLTSCR2	0.857987873	6.65E-15
DLBC	TSG	RPL19	GNB2L1	0.941727768	2.12E-23
GBM	Cell metabolism gene	RPL19	FAU	0.834254613	8.13E-46
KICH	Cell metabolism gene	RPL19	NME1	0.81078408	2.06E-22
KICH	Cell metabolism gene	RPL19	PSMB3	0.837188976	4.74E-25
KICH	Cell metabolism gene	RPL19	SSR2	0.852031464	9.48E-27
KICH	IUPHAR	RPL19	CSNK2B	0.854430018	4.84E-27
KICH	TSG	RPL19	NME1	0.81078408	2.06E-22
KICH	TSG	RPL19	GAS5	0.813009487	1.28E-22
KIRP	Cell metabolism gene	RPL19	NME1	0.805322487	7.14E-75
KIRP	Cell metabolism gene	RPL19	FAU	0.814824297	5.33E-78
KIRP	Cell metabolism gene	RPL19	NME2	0.841806733	5.81E-88
KIRP	Cell metabolism gene	RPL19	SNRPD2	0.853513744	6.92E-93
KIRP	Cell metabolism gene	RPL19	PSMB3	0.864618469	5.70E-98
KIRP	TF	RPL19	NME2	0.841806733	5.81E-88
KIRP	TSG	RPL19	NME1	0.805322487	7.14E-75
LGG	Cell metabolism gene	RPL19	IMPDH2	0.801324132	6.65E-120
LGG	Cell metabolism gene	RPL19	FAU	0.920285693	2.46E-217
LGG	CGC	RPL19	NACA	0.848044482	9.93E-148
LGG	IUPHAR	RPL19	IMPDH2	0.801324132	6.65E-120
LGG	TSG	RPL19	GAS5	0.823108736	7.47E-132
LGG	TSG	RPL19	GNB2L1	0.875848897	3.35E-169
PAAD	Cell metabolism gene	RPL19	FAU	0.806861758	3.07E-43
PCPG	Cell metabolism gene	RPL19	PSMB3	0.802532588	2.31E-43
PRAD	Cell metabolism gene	RPL19	PGLS	0.80337925	1.78E-125
PRAD	Cell metabolism gene	RPL19	POLR2I	0.808687571	2.18E-128
PRAD	Cell metabolism gene	RPL19	POLR2F	0.824381478	1.49E-137
PRAD	Cell metabolism gene	RPL19	TIMM9	0.828962979	2.11E-140
PRAD	Cell metabolism gene	RPL19	SNRPD2	0.845894258	1.02E-151
PRAD	Cell metabolism gene	RPL19	NME2	0.859988557	3.11E-162
PRAD	Cell metabolism gene	RPL19	FAU	0.876491375	4.09E-176
PRAD	CGC	RPL19	NACA	0.863520305	4.74E-165
PRAD	Epifactor	RPL19	FBL	0.85651714	1.53E-159
PRAD	TF	RPL19	ZNF524	0.810303563	2.73E-129
PRAD	TF	RPL19	NME2	0.859988557	3.11E-162
PRAD	TSG	RPL19	GAS5	0.816002532	1.50E-132
PRAD	TSG	RPL19	GNB2L1	0.886891771	6.26E-186
TGCT	Cell metabolism gene	RPL19	FAU	0.817980467	8.14E-39
THCA	Cell metabolism gene	RPL19	POLR2I	0.804844067	2.90E-131
THCA	Cell metabolism gene	RPL19	SNRPD2	0.858748397	1.16E-167
THCA	Cell metabolism gene	RPL19	PFDN5	0.874073108	7.24E-181
THCA	Cell metabolism gene	RPL19	FAU	0.894912686	6.71E-202
THCA	CGC	RPL19	NACA	0.814085817	1.21E-136
THCA	TSG	RPL19	GNB2L1	0.805825427	8.03E-132
THCA	TSG	RPL19	AIP	0.811543423	3.92E-135
THCA	TSG	RPL19	GADD45GIP1	0.812502056	1.06E-135
THYM	Cell metabolism gene	RPL19	MTX1	0.80161845	1.40E-28
THYM	Cell metabolism gene	RPL19	SNRPE	0.801977342	1.27E-28
THYM	Cell metabolism gene	RPL19	FPGS	0.802060389	1.24E-28
THYM	Cell metabolism gene	RPL19	PSMC5	0.804211401	6.90E-29
THYM	Cell metabolism gene	RPL19	TXN	0.807177481	3.03E-29
THYM	Cell metabolism gene	RPL19	PSMA4	0.80833186	2.20E-29
THYM	Cell metabolism gene	RPL19	PSMB1	0.808395115	2.16E-29
THYM	Cell metabolism gene	RPL19	TIMM10	0.809583468	1.54E-29
THYM	Cell metabolism gene	RPL19	POLR2J	0.80992021	1.40E-29
THYM	Cell metabolism gene	RPL19	POLR2F	0.813295615	5.33E-30
THYM	Cell metabolism gene	RPL19	GEMIN7	0.814452912	3.81E-30
THYM	Cell metabolism gene	RPL19	DTYMK	0.814662068	3.58E-30
THYM	Cell metabolism gene	RPL19	MTMR14	0.815701311	2.64E-30
THYM	Cell metabolism gene	RPL19	PSMB10	0.81600705	2.42E-30
THYM	Cell metabolism gene	RPL19	PSME1	0.816074322	2.37E-30
THYM	Cell metabolism gene	RPL19	PAFAH1B3	0.816504519	2.09E-30
THYM	Cell metabolism gene	RPL19	EXOSC4	0.818595626	1.12E-30
THYM	Cell metabolism gene	RPL19	SRM	0.819630013	8.22E-31
THYM	Cell metabolism gene	RPL19	LSM5	0.819917025	7.54E-31
THYM	Cell metabolism gene	RPL19	HMBS	0.821971373	4.04E-31
THYM	Cell metabolism gene	RPL19	SNRPB	0.825286282	1.45E-31
THYM	Cell metabolism gene	RPL19	EBP	0.827228933	7.91E-32
THYM	Cell metabolism gene	RPL19	POLR2I	0.82918142	4.25E-32
THYM	Cell metabolism gene	RPL19	TOMM22	0.830402177	2.87E-32
THYM	Cell metabolism gene	RPL19	POLR2H	0.831421122	2.07E-32
THYM	Cell metabolism gene	RPL19	PFDN6	0.831797005	1.83E-32
THYM	Cell metabolism gene	RPL19	SNRPD3	0.832190054	1.61E-32
THYM	Cell metabolism gene	RPL19	GEMIN6	0.834801936	6.82E-33
THYM	Cell metabolism gene	RPL19	ITPA	0.835265741	5.85E-33
THYM	Cell metabolism gene	RPL19	SMPD2	0.835967041	4.63E-33
THYM	Cell metabolism gene	RPL19	SNRPD1	0.836691898	3.63E-33
THYM	Cell metabolism gene	RPL19	PGLS	0.837073905	3.19E-33
THYM	Cell metabolism gene	RPL19	ACOT8	0.837970518	2.36E-33
THYM	Cell metabolism gene	RPL19	TOMM40	0.839642674	1.33E-33
THYM	Cell metabolism gene	RPL19	PHKG2	0.839729133	1.30E-33
THYM	Cell metabolism gene	RPL19	TIMM50	0.840053621	1.16E-33
THYM	Cell metabolism gene	RPL19	SSR2	0.840434882	1.02E-33
THYM	Cell metabolism gene	RPL19	SNRPF	0.846078052	1.40E-34
THYM	Cell metabolism gene	RPL19	TIMM13	0.846404115	1.24E-34
THYM	Cell metabolism gene	RPL19	LSM4	0.846427253	1.23E-34
THYM	Cell metabolism gene	RPL19	EXOSC5	0.849160468	4.58E-35
THYM	Cell metabolism gene	RPL19	DGUOK	0.850968969	2.35E-35
THYM	Cell metabolism gene	RPL19	SLC27A5	0.853538394	8.96E-36
THYM	Cell metabolism gene	RPL19	LSM2	0.854446402	6.35E-36
THYM	Cell metabolism gene	RPL19	EXOSC1	0.859191838	1.01E-36
THYM	Cell metabolism gene	RPL19	PSMB7	0.860373308	6.30E-37
THYM	Cell metabolism gene	RPL19	APRT	0.867428936	3.50E-38
THYM	Cell metabolism gene	RPL19	PFDN5	0.868995061	1.80E-38
THYM	Cell metabolism gene	RPL19	PSMC3	0.870800321	8.27E-39
THYM	Cell metabolism gene	RPL19	PSMD13	0.876949021	5.37E-40
THYM	Cell metabolism gene	RPL19	PSMB3	0.883963322	1.97E-41
THYM	Cell metabolism gene	RPL19	SNRPD2	0.903790102	4.73E-46
THYM	Cell metabolism gene	RPL19	TIMM8B	0.905536658	1.66E-46
THYM	Cell metabolism gene	RPL19	FAU	0.92209126	2.62E-51
THYM	CGC	RPL19	TFPT	0.811786144	8.24E-30
THYM	CGC	RPL19	SDHAF2	0.855988158	3.52E-36
THYM	Epifactor	RPL19	PRMT1	0.802715468	1.04E-28
THYM	Epifactor	RPL19	C17orf49	0.804374642	6.59E-29
THYM	Epifactor	RPL19	SIRT7	0.806560177	3.60E-29
THYM	Epifactor	RPL19	CXXC1	0.806934352	3.25E-29
THYM	Epifactor	RPL19	TFPT	0.811786144	8.24E-30
THYM	Epifactor	RPL19	EXOSC4	0.818595626	1.12E-30
THYM	Epifactor	RPL19	PRPF31	0.822601092	3.34E-31
THYM	Epifactor	RPL19	CCDC101	0.824730888	1.73E-31
THYM	Epifactor	RPL19	ZNHIT1	0.82861992	5.09E-32
THYM	Epifactor	RPL19	PPM1G	0.830367552	2.91E-32
THYM	Epifactor	RPL19	NOC2L	0.833023823	1.23E-32
THYM	Epifactor	RPL19	EXOSC5	0.849160468	4.58E-35
THYM	Epifactor	RPL19	INO80E	0.854073583	7.32E-36
THYM	Epifactor	RPL19	PPP4C	0.857692798	1.82E-36
THYM	Epifactor	RPL19	EXOSC1	0.859191838	1.01E-36
THYM	Epifactor	RPL19	SS18L2	0.859907875	7.59E-37
THYM	Epifactor	RPL19	RUVBL2	0.867220337	3.82E-38
THYM	Epifactor	RPL19	SIRT6	0.86758637	3.27E-38
THYM	Epifactor	RPL19	FBL	0.872519553	3.91E-39
THYM	Epifactor	RPL19	BRMS1	0.878919569	2.16E-40
THYM	Epifactor	RPL19	TAF10	0.908935373	2.04E-47
THYM	IUPHAR	RPL19	PRMT1	0.802715468	1.04E-28
THYM	IUPHAR	RPL19	SIRT7	0.806560177	3.60E-29
THYM	IUPHAR	RPL19	PSMB1	0.808395115	2.16E-29
THYM	IUPHAR	RPL19	PPIA	0.832454128	1.48E-32
THYM	IUPHAR	RPL19	SMPD2	0.835967041	4.63E-33
THYM	IUPHAR	RPL19	PHKG2	0.839729133	1.30E-33
THYM	IUPHAR	RPL19	SLC27A5	0.853538394	8.96E-36
THYM	IUPHAR	RPL19	SIRT6	0.86758637	3.27E-38
THYM	Kinase	RPL19	PHKG2	0.839729133	1.30E-33
THYM	TF	RPL19	THAP3	0.80292371	9.81E-29
THYM	TF	RPL19	IRF3	0.803456911	8.48E-29
THYM	TF	RPL19	CXXC1	0.806934352	3.25E-29
THYM	TF	RPL19	GTF3A	0.807324134	2.91E-29
THYM	TF	RPL19	ZNF668	0.816742718	1.94E-30
THYM	TF	RPL19	ZNF511	0.819177061	9.42E-31
THYM	TF	RPL19	DRAP1	0.820018782	7.31E-31
THYM	TF	RPL19	ZNF444	0.827775406	6.65E-32
THYM	TF	RPL19	THYN1	0.831222598	2.21E-32
THYM	TF	RPL19	ZNF688	0.843016169	4.14E-34
THYM	TF	RPL19	ZNF787	0.845566093	1.68E-34
THYM	TF	RPL19	ZNF428	0.848728383	5.36E-35
THYM	TSG	RPL19	IRF3	0.803456911	8.48E-29
THYM	TSG	RPL19	PFN1	0.80660718	3.56E-29
THYM	TSG	RPL19	ZNF668	0.816742718	1.94E-30
THYM	TSG	RPL19	TSSC4	0.838028033	2.31E-33
THYM	TSG	RPL19	GADD45GIP1	0.842411765	5.12E-34
THYM	TSG	RPL19	HTRA2	0.843438125	3.57E-34
THYM	TSG	RPL19	AIP	0.846356964	1.27E-34
THYM	TSG	RPL19	PARK7	0.857342423	2.08E-36
THYM	TSG	RPL19	NPRL2	0.860228602	6.68E-37
THYM	TSG	RPL19	SIRT6	0.86758637	3.27E-38
THYM	TSG	RPL19	GNB2L1	0.873247649	2.83E-39
THYM	TSG	RPL19	BRMS1	0.878919569	2.16E-40
THYM	TSG	RPL19	GLTSCR2	0.882080277	4.88E-41
UCS	Cell metabolism gene	RPL19	MTX1	0.80161845	1.40E-28
UCS	Cell metabolism gene	RPL19	SNRPE	0.801977342	1.27E-28
UCS	Cell metabolism gene	RPL19	FPGS	0.802060389	1.24E-28
UCS	Cell metabolism gene	RPL19	PSMC5	0.804211401	6.90E-29
UCS	Cell metabolism gene	RPL19	TXN	0.807177481	3.03E-29
UCS	Cell metabolism gene	RPL19	PSMA4	0.80833186	2.20E-29
UCS	Cell metabolism gene	RPL19	PSMB1	0.808395115	2.16E-29
UCS	Cell metabolism gene	RPL19	TIMM10	0.809583468	1.54E-29
UCS	Cell metabolism gene	RPL19	POLR2J	0.80992021	1.40E-29
UCS	Cell metabolism gene	RPL19	POLR2F	0.813295615	5.33E-30
UCS	Cell metabolism gene	RPL19	GEMIN7	0.814452912	3.81E-30
UCS	Cell metabolism gene	RPL19	DTYMK	0.814662068	3.58E-30
UCS	Cell metabolism gene	RPL19	MTMR14	0.815701311	2.64E-30
UCS	Cell metabolism gene	RPL19	PSMB10	0.81600705	2.42E-30
UCS	Cell metabolism gene	RPL19	PSME1	0.816074322	2.37E-30
UCS	Cell metabolism gene	RPL19	PAFAH1B3	0.816504519	2.09E-30
UCS	Cell metabolism gene	RPL19	EXOSC4	0.818595626	1.12E-30
UCS	Cell metabolism gene	RPL19	SRM	0.819630013	8.22E-31
UCS	Cell metabolism gene	RPL19	LSM5	0.819917025	7.54E-31
UCS	Cell metabolism gene	RPL19	HMBS	0.821971373	4.04E-31
UCS	Cell metabolism gene	RPL19	SNRPB	0.825286282	1.45E-31
UCS	Cell metabolism gene	RPL19	EBP	0.827228933	7.91E-32
UCS	Cell metabolism gene	RPL19	POLR2I	0.82918142	4.25E-32
UCS	Cell metabolism gene	RPL19	TOMM22	0.830402177	2.87E-32
UCS	Cell metabolism gene	RPL19	POLR2H	0.831421122	2.07E-32
UCS	Cell metabolism gene	RPL19	PFDN6	0.831797005	1.83E-32
UCS	Cell metabolism gene	RPL19	SNRPD3	0.832190054	1.61E-32
UCS	Cell metabolism gene	RPL19	GEMIN6	0.834801936	6.82E-33
UCS	Cell metabolism gene	RPL19	ITPA	0.835265741	5.85E-33
UCS	Cell metabolism gene	RPL19	SMPD2	0.835967041	4.63E-33
UCS	Cell metabolism gene	RPL19	SNRPD1	0.836691898	3.63E-33
UCS	Cell metabolism gene	RPL19	PGLS	0.837073905	3.19E-33
UCS	Cell metabolism gene	RPL19	ACOT8	0.837970518	2.36E-33
UCS	Cell metabolism gene	RPL19	TOMM40	0.839642674	1.33E-33
UCS	Cell metabolism gene	RPL19	PHKG2	0.839729133	1.30E-33
UCS	Cell metabolism gene	RPL19	TIMM50	0.840053621	1.16E-33
UCS	Cell metabolism gene	RPL19	SSR2	0.840434882	1.02E-33
UCS	Cell metabolism gene	RPL19	SNRPF	0.846078052	1.40E-34
UCS	Cell metabolism gene	RPL19	TIMM13	0.846404115	1.24E-34
UCS	Cell metabolism gene	RPL19	LSM4	0.846427253	1.23E-34
UCS	Cell metabolism gene	RPL19	EXOSC5	0.849160468	4.58E-35
UCS	Cell metabolism gene	RPL19	DGUOK	0.850968969	2.35E-35
UCS	Cell metabolism gene	RPL19	SLC27A5	0.853538394	8.96E-36
UCS	Cell metabolism gene	RPL19	LSM2	0.854446402	6.35E-36
UCS	Cell metabolism gene	RPL19	EXOSC1	0.859191838	1.01E-36
UCS	Cell metabolism gene	RPL19	PSMB7	0.860373308	6.30E-37
UCS	Cell metabolism gene	RPL19	APRT	0.867428936	3.50E-38
UCS	Cell metabolism gene	RPL19	PFDN5	0.868995061	1.80E-38
UCS	Cell metabolism gene	RPL19	PSMC3	0.870800321	8.27E-39
UCS	Cell metabolism gene	RPL19	PSMD13	0.876949021	5.37E-40
UCS	Cell metabolism gene	RPL19	PSMB3	0.883963322	1.97E-41
UCS	Cell metabolism gene	RPL19	SNRPD2	0.903790102	4.73E-46
UCS	Cell metabolism gene	RPL19	TIMM8B	0.905536658	1.66E-46
UCS	Cell metabolism gene	RPL19	FAU	0.92209126	2.62E-51
UCS	CGC	RPL19	TFPT	0.811786144	8.24E-30
UCS	CGC	RPL19	SDHAF2	0.855988158	3.52E-36
UCS	Epifactor	RPL19	PRMT1	0.802715468	1.04E-28
UCS	Epifactor	RPL19	C17orf49	0.804374642	6.59E-29
UCS	Epifactor	RPL19	SIRT7	0.806560177	3.60E-29
UCS	Epifactor	RPL19	CXXC1	0.806934352	3.25E-29
UCS	Epifactor	RPL19	TFPT	0.811786144	8.24E-30
UCS	Epifactor	RPL19	EXOSC4	0.818595626	1.12E-30
UCS	Epifactor	RPL19	PRPF31	0.822601092	3.34E-31
UCS	Epifactor	RPL19	CCDC101	0.824730888	1.73E-31
UCS	Epifactor	RPL19	ZNHIT1	0.82861992	5.09E-32
UCS	Epifactor	RPL19	PPM1G	0.830367552	2.91E-32
UCS	Epifactor	RPL19	NOC2L	0.833023823	1.23E-32
UCS	Epifactor	RPL19	EXOSC5	0.849160468	4.58E-35
UCS	Epifactor	RPL19	INO80E	0.854073583	7.32E-36
UCS	Epifactor	RPL19	PPP4C	0.857692798	1.82E-36
UCS	Epifactor	RPL19	EXOSC1	0.859191838	1.01E-36
UCS	Epifactor	RPL19	SS18L2	0.859907875	7.59E-37
UCS	Epifactor	RPL19	RUVBL2	0.867220337	3.82E-38
UCS	Epifactor	RPL19	SIRT6	0.86758637	3.27E-38
UCS	Epifactor	RPL19	FBL	0.872519553	3.91E-39
UCS	Epifactor	RPL19	BRMS1	0.878919569	2.16E-40
UCS	Epifactor	RPL19	TAF10	0.908935373	2.04E-47
UCS	IUPHAR	RPL19	PRMT1	0.802715468	1.04E-28
UCS	IUPHAR	RPL19	SIRT7	0.806560177	3.60E-29
UCS	IUPHAR	RPL19	PSMB1	0.808395115	2.16E-29
UCS	IUPHAR	RPL19	PPIA	0.832454128	1.48E-32
UCS	IUPHAR	RPL19	SMPD2	0.835967041	4.63E-33
UCS	IUPHAR	RPL19	PHKG2	0.839729133	1.30E-33
UCS	IUPHAR	RPL19	SLC27A5	0.853538394	8.96E-36
UCS	IUPHAR	RPL19	SIRT6	0.86758637	3.27E-38
UCS	Kinase	RPL19	PHKG2	0.839729133	1.30E-33
UCS	TF	RPL19	THAP3	0.80292371	9.81E-29
UCS	TF	RPL19	IRF3	0.803456911	8.48E-29
UCS	TF	RPL19	CXXC1	0.806934352	3.25E-29
UCS	TF	RPL19	GTF3A	0.807324134	2.91E-29
UCS	TF	RPL19	ZNF668	0.816742718	1.94E-30
UCS	TF	RPL19	ZNF511	0.819177061	9.42E-31
UCS	TF	RPL19	DRAP1	0.820018782	7.31E-31
UCS	TF	RPL19	ZNF444	0.827775406	6.65E-32
UCS	TF	RPL19	THYN1	0.831222598	2.21E-32
UCS	TF	RPL19	ZNF688	0.843016169	4.14E-34
UCS	TF	RPL19	ZNF787	0.845566093	1.68E-34
UCS	TF	RPL19	ZNF428	0.848728383	5.36E-35
UCS	TSG	RPL19	IRF3	0.803456911	8.48E-29
UCS	TSG	RPL19	PFN1	0.80660718	3.56E-29
UCS	TSG	RPL19	ZNF668	0.816742718	1.94E-30
UCS	TSG	RPL19	TSSC4	0.838028033	2.31E-33
UCS	TSG	RPL19	GADD45GIP1	0.842411765	5.12E-34
UCS	TSG	RPL19	HTRA2	0.843438125	3.57E-34
UCS	TSG	RPL19	AIP	0.846356964	1.27E-34
UCS	TSG	RPL19	PARK7	0.857342423	2.08E-36
UCS	TSG	RPL19	NPRL2	0.860228602	6.68E-37
UCS	TSG	RPL19	SIRT6	0.86758637	3.27E-38
UCS	TSG	RPL19	GNB2L1	0.873247649	2.83E-39
UCS	TSG	RPL19	BRMS1	0.878919569	2.16E-40
UCS	TSG	RPL19	GLTSCR2	0.882080277	4.88E-41
UVM	Cell metabolism gene	RPL19	NME2	0.81147569	7.00E-20
UVM	Cell metabolism gene	RPL19	FAU	0.822181955	8.89E-21
UVM	TF	RPL19	NME2	0.81147569	7.00E-20
UVM	TSG	RPL19	GLTSCR2	0.805869039	1.96E-19
UVM	TSG	RPL19	GNB2L1	0.810331464	8.66E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL19	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL19	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL19	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL19	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL19	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL19	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL19	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL19	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL19	RPS12	1.26997381758431	0.00308787822723389
THCA	RPL19	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL19	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL19	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL19	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL19	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL19	RPS11	1.35307548998204	0.0312207043170929
UCEC	RPL19	RPS23	-2.03658159814007	0.046875
BRCA	RPL19	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL19	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL19	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL19	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL19	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL19	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL19	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL19	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL19	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL19	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL19	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL19

HDGF, ARRB2, SIRT7, TERF1, CUL3, CUL4A, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL21, RPL22, RPL23, RPL24, RPL27A, RPL30, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL9, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS19, RPS23, RPS25, RPS26, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL8, RPL23A, RPS24, RPS11, RPS28, RPL10, RPS20, RPS12, RPLP0, RPL36, RPL27, RPS9, RPL17, RPL32, RPS27A, RPS21, NOP56, NCL, ILF3, RSL1D1, HNRNPU, GNL3, ILF2, SRP14, SLC25A5, EIF4A1, FBL, NOP58, TUFM, DDX21, NHP2L1, LUC7L2, NOLC1, HNRNPM, NIFK, NOP2, RPLP0P6, RPL10L, RPS27L, RRS1, SND1, PTGES3, GNB2L1, ECE1, NUP214, TUBB7P, DDX5, MRPL12, ESR1, MAGOH, EIF4A3, UBL4A, PAN2, IGSF8, ICAM1, COX11, YWHAQ, TARDBP, PARP1, KARS, NMT1, QARS, RPLP1, RPA3, RPA2, RPA1, STAU1, CEP250, TP53, CUL7, OBSL1, RNF2, RPS6KB2, RPL13A, RPL38, RPS29, RPL26, RPL28, RPL34, RPL35, RPL35A, RPL3L, RPLP2, RPS10, RPS15, RPS18, LOC101929876, SEC61A1, NTRK1, HIST1H3E, NPM1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, Ksr1, E4F1, ZCRB1, SART3, H2AFX, CYLD, INO80B, TRIM25, YAP1, MTF1, TRIM14, GSK3A, ARNT, BMP4, MAP2K3, PCBP1, PYHIN1, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, RNF4, CHD4, RIOK1, FGF11, HEXIM1, MEPCE, LARP7, SNAI1, RECQL4, REST, MYC, HIST1H3A, METTL14, KIAA1429, RC3H1, RC3H2, ACTC1, PHB, RBX1, KIN, NR2C2, PPP1CC, CTCF, NINL, VRK1, HIST1H4A, SNRNP70, Dppa3, PTPN21, ITFG1, HMGB1, BIRC3, WWP2, CMTR1, ARIH2, PLEKHA4, KCTD10, PINK1, FANCD2, HCVgp1, ZC3H18, GRB7, MAP3K14, PTPN6, HIST2H2BE, FMNL3, IGF2R, FKBP2, TMEM132C, TEX15, NISCH, ORF8, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, LRRC59, NDN, Rnf183, BRD4, N, Apc2, RBM39, FBP1, RIN3, PARK2, UFL1, DDRGK1, TRIM37, ATG3, USP15, FZR1, WDR5, PAGE4, NUDCD2, NAA40, WHSC1, ADARB1, PURA, RRP8, MRPL45, RSBN1, AATF, MALSU1, MRPL49, RPL26L1, HIST2H2AC, YTHDF1, SF3B1, NGDN, ZNF22, PRR3, MRPL11, MRPL9, MRPL1, MRPL38, MRPL40, ZNF646, ZNF384, MRPL28, NPM3, DHX8, MRPL47, MRPL16, GADD45GIP1, ZFR, MRPL50, PABPC4L, MRPL55, DDX55, BMS1, ZFP62, CHERP, ISG20L2, MRPL30, MRPS30, PRDM15, RRP12, STRBP, GZF1, BHLHA15, ZNF768, KNOP1, NOC2L, MRPS15, MRPS9, MRPS25, MRPL21, ZNF346, GTPBP4, YTHDC1, GLE1, ZNF777, TOE1, H1FOO, ZNF771, KRR1, ZNF770, PRKRIR, ZNF70, KRI1, RPL36AL, NOC4L, PRKRA, ZBTB24, STAU2, DDX18, RBM34, BUD13, REXO4, HERC5, ZFP91, RBM19, MRPL23, SF3B2, MRPL13, DAXX, MINA, TRIM71, MRPL44, MRPL43, FARS2, NOL10, MRPL10, CCDC140, ZKSCAN8, MRPL51, SRSF1, DDX10, BLM, YBX1, MRPL39, MRPL32, MRPL24, CEBPZ, NOA1, MRPL22, MRPL2, NAT10, MPHOSPH10, SREK1, RBM5, ZNF668, ZNF624, GNL2, RSBN1L, DHX57, WDR55, ZC3HAV1, MRPL34, ICT1, MRPS10, YBX2, MRPS7, ZNF629, NOC3L, SRSF6, SRSF5, ZSCAN25, UTP23, ZBTB11, ZNF16, ELAVL4, MRPL18, DDX31, MRPL15, MRPS26, ZNF574, RBM28, ABT1, PTCD3, METTL17, MRPL42, PRPF4B, MRPL3, MAP7D1, C7orf50, WDR74, GLYR1, DDX27, YTHDC2, MRPL20, GLTSCR2, EPB41L5, FAM111A, ZNF512, MRPL27, MRPL52, MRPL57, MRPS17, MRPS18C, PAK1IP1, MRPL4, MRPS35, SRSF10, RSL24D1, OASL, CCDC137, DDX50, DKC1, MRPL48, DDX24, MRPS5, VPRBP, LARP1B, MAGEB2, SURF6, NKRF, EIF2AK2, SCAF1, GAR1, HIST2H2AB, PPAN-P2RY11, DAP3, MTERF3, APOBEC3F, LTV1, MRPL41, DDX54, NOL12, DHX36, MAK16, RPL7L1, MRPL37, POP1, YBX3, MRPS14, MRPS11, NOP16, FTSJ3, MRPL35, MRPL17, NSA2, MRPL46, RPS4Y2, BTF3, FBXW7, EIF4ENIF1, Rbm14, NLRP7, RCHY1, CCNF, OPTN, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL19	chr17	37356599	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
RPL19	chr17	37357506	CG	AT	Indel	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL19	chr17	37357556	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37358647	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37358679	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37359324	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37359356	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL19	chr17	37360342	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37360769	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL19	chr17	37360793	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37360844	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37360846	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL19	chr17	37360863	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL19	chr17	37360874	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37360889	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL19	chr17	37360895	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL19	PCPG	chr17	37360890	37360890	A	G	Missense_Mutation	p.T194A	4
RPL19	BRCA	chr17	37358625	37358625	G	A	Silent	p.T56	3
RPL19	BRCA	chr17	37359326	37359326	G	A	Missense_Mutation	p.R107K	3
RPL19	KIRC	chr17	37360863	37360863	A	T	Missense_Mutation	p.I185F	3
RPL19	KIRP	chr17	37358657	37358657	C	T	Missense_Mutation		2
RPL19	UCEC	chr17	37358641	37358641	C	T	Nonsense_Mutation	p.R62*	2
RPL19	UCEC	chr17	37359247	37359247	C	T	Missense_Mutation	p.R81W	2
RPL19	UCEC	chr17	37359332	37359332	A	G	Missense_Mutation	p.Y109C	2
RPL19	UCEC	chr17	37359355	37359355	C	T	Missense_Mutation	p.R117C	2
RPL19	TGCT	chr17	37360424	37360424	C	T	Missense_Mutation	p.R151C	2
RPL19	KIRP	chr17	37358657	37358657	C	T	Missense_Mutation	p.T67I	2
RPL19	THYM	chr17	37359313	37359313	C	T	Missense_Mutation	p.R103C	2
RPL19	SKCM	chr17	37358611	37358611	C	T	Missense_Mutation	p.R52C	1
RPL19	BLCA	chr17	37360850	37360850	G	C	Missense_Mutation		1
RPL19	THYM	chr17	37360425	37360425	G	A	Missense_Mutation	p.R151H	1
RPL19	LIHC	chr17	37357506	37357506	C	T	Missense_Mutation	p.R16C	1
RPL19	SKCM	chr17	37360881	37360881	G	A	Missense_Mutation	p.E189K	1
RPL19	BLCA	chr17	37360850	37360850	G	C	Missense_Mutation	p.K178N	1
RPL19	LUAD	chr17	37358692	37358692	G	T	Splice_Site	p.G77_splice	1
RPL19	SKCM	chr17	37357520	37357520	G	A	Silent	p.K18K	1
RPL19	LUAD	chr17	37357505	37357505	C	T	Silent	p.L13L	1
RPL19	SKCM	chr17	37358611	37358611	C	T	Missense_Mutation	p.R50C	1
RPL19	LUAD	chr17	37360818	37360818	C	G	Missense_Mutation	p.R168G	1
RPL19	STAD	chr17	37359334	37359334	C	T	Missense_Mutation	p.R110C	1
RPL19	COAD	chr17	37360385	37360385	C	T	Missense_Mutation	p.L138F	1
RPL19	LUAD	chr17	37358692	37358692	G	T	Missense_Mutation	p.G79C	1
RPL19	STAD	chr17	37359273	37359273	G	T	Missense_Mutation	p.M89I	1
RPL19	LUSC	chr17	37357551	37357551	G	A	Missense_Mutation	p.E31K	1
RPL19	KIRC	chr17	37357533	37357533	G	C	Missense_Mutation	p.D25H	1
RPL19	PAAD	chr17	37357437	37357437	G	A	Missense_Mutation		1
RPL19	THCA	chr17	37360844	37360844	G	A	Silent		1
RPL19	KIRC	chr17	37360793	37360793	C	T	Silent	p.A161A	1
RPL19	THCA	chr17	37360846	37360846	C	T	Missense_Mutation		1
RPL19	KIRC	chr17	37360846	37360846	C	T	Missense_Mutation	p.A179V	1
RPL19	PRAD	chr17	37360425	37360425	G	A	Missense_Mutation	p.R149H	1
RPL19	BLCA	chr17	37357435	37357435	C	T	Missense_Mutation		1
RPL19	THYM	chr17	37359313	37359313	C	T	Missense_Mutation		1
RPL19	PRAD	chr17	37357515	37357517	AAG	-	In_Frame_Del	p.K19del	1
RPL19	BLCA	chr17	37357472	37357472	C	T	Silent		1

Copy number variation (CNV) of RPL19
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL19
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
57232	BRCA	TCGA-A8-A08B-01A	CACNB1	chr17	37341037	-	RPL19	chr17	37358570	+
57232	LAML	TCGA-AB-2932_704G6AAXX_6	CDK12	chr17	37628016	+	RPL19	chr17	37359242	+
57232	N/A	BI496727	DLG2	chr11	83548765	-	RPL19	chr17	37360980	-
57232	N/A	AA075993	FAM153C	chr5	177482847	-	RPL19	chr17	37360980	-
57232	N/A	AA491515	FAM153C	chr5	177483265	+	RPL19	chr17	37360330	+
57232	N/A	AA164713	ISPD	chr7	16328015	-	RPL19	chr17	37360975	-
57233	N/A	EC555197	NAPEPLD	chr7	102782084	-	RPL19	chr17	37359240	+
76103	N/A	AA579455	RPL19	chr17	37360821	+	AC009997.1	chr15	56038831	+
99398	N/A	BI861713	RPL19	chr17	37360975	+	ADAM9	chr8	38871032	-
76103	N/A	DT217361	RPL19	chr17	37360365	+	ALAD	chr9	116155751	-
76103	N/A	AW021565	RPL19	chr17	37360980	+	ALOX12P2	chr17	6840435	+
99260	Non-Cancer	TCGA-IP-7968-11A	RPL19	chr17	37357572	+	CACNB1	chr17	37351223	-
76103	BRCA	TCGA-BH-A0B7	RPL19	chr17	37356602	+	CCL11	chr17	32614114	+
76103	BRCA	TCGA-BH-A0B7-01A	RPL19	chr17	37356602	+	CCL11	chr17	32614115	+
76103	BRCA	TCGA-BH-A0B7-01A	RPL19	chr17	37356731	+	CCL11	chr17	32614115	+
94731	N/A	BF526730	RPL19	chr17	37360975	+	CEP152	chr15	49020117	+
76103	N/A	AV682672	RPL19	chr17	37360980	+	ERVMER34-1	chr4	53592064	-
76103	N/A	AA316329	RPL19	chr17	37359365	+	FAM153C	chr5	177482622	+
76103	N/A	AA541786	RPL19	chr17	37358569	-	FAM153C	chr5	177483111	-
76103	N/A	BI855679	RPL19	chr17	37360980	+	FAM153C	chr5	177482611	+
76103	N/A	BI858244	RPL19	chr17	37360980	+	FAM153C	chr5	177482622	+
76103	N/A	BI858270	RPL19	chr17	37360870	-	FAM153C	chr5	177483187	+
76103	N/A	HH980979	RPL19	chr17	37360980	+	FAM153C	chr5	177482573	+
100117	N/A	BI496198	RPL19	chr17	37360975	+	ISPD	chr7	16328015	+
96230	MESO	TCGA-MQ-A6BR-01A	RPL19	chr17	37357572	+	ITLN1	chr1	160846606	-
94447	N/A	BE720744	RPL19	chr17	37360412	-	KRT13	chr17	39657355	-
87953	N/A	BG575833	RPL19	chr17	37360980	+	MAGI1	chr3	65935556	+
100576	N/A	AA508102	RPL19	chr17	37360980	+	MAP2K5	chr15	67843129	-
95663	N/A	BI493272	RPL19	chr17	37360980	+	PPP6R2	chr22	50828443	-
102036	N/A	BM013487	RPL19	chr17	37360975	+	PRKCZ	chr1	2078034	-
102127	N/A	AA483007	RPL19	chr17	37360980	+	RAPGEF4	chr2	173736372	-
83858	BRCA	TCGA-OL-A5RZ-01A	RPL19	chr17	37359365	+	RPS24	chr10	79800367	+
102305	N/A	AW021900	RPL19	chr17	37360980	+	STX8	chr17	9353128	-
92453	N/A	T20077	RPL19	chr17	37360975	+	ZNF407	chr18	72724905	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL19	0.0269158656989509	0.75

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL19	0.000456375023925282	0.015
PAAD	RPL19	0.00813363357155575	0.26
CHOL	RPL19	0.0432762826814578	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	1	GENOMICS_ENGLAND