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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL28 (NCBI Gene ID:6158)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL28
	Gene ID: 6158
	Gene Symbol	RPL28
	Gene ID	6158
	Gene Name	ribosomal protein L28
	Synonyms	L28
	Cytomap	19q13.42
	Type of Gene	protein-coding
	Description	60S ribosomal protein L28large ribosomal subunit protein eL28
	Modification date	20200313
	UniProtAcc	P46779

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL28	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'RPL28[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL28	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	RPL28	-1.47729232710219	0.000489473342895508
LUSC	RPL28	-1.20199087596315	0.0135147608121283
HNSC	RPL28	-1.43542795889237	0.0422964299507385
KIRC	RPL28	-1.00208160167019	2.24154358356525e-09
KIRP	RPL28	-2.04574468571075	5.8719888329506e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
STAD	RPL28	2	1	0.0330522823113542	0.222403846153846	0.162373056786146	0.0408595912418174	-0.0753583021982701

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	RPL28	1	2	0.0134805995839495	0.182698571428572	0.308064786967419	0.8314428794388	0.547019896982095

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	RPL28	0.06326325	0.026975177
KIRC	RPL28	-0.038568264	0.029825749

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL28 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	RPL28	SNRPD2	0.841664419	2.66E-22
ACC	Epifactor	RPL28	TRIM28	0.80938595	1.77E-19
ACC	IUPHAR	RPL28	TRIM28	0.80938595	1.77E-19
ACC	Kinase	RPL28	TRIM28	0.80938595	1.77E-19
CHOL	Cell metabolism gene	RPL28	SNRPD2	0.846879172	2.28E-13
CHOL	Epifactor	RPL28	FBL	0.806580351	2.26E-11
CHOL	TF	RPL28	ZNF581	0.84005093	5.42E-13
CHOL	TSG	RPL28	GLTSCR2	0.877714143	2.50E-15
DLBC	Cell metabolism gene	RPL28	LSM2	0.802329176	7.08E-12
DLBC	Cell metabolism gene	RPL28	GEMIN7	0.805196772	5.23E-12
DLBC	Cell metabolism gene	RPL28	GFER	0.817645963	1.32E-12
DLBC	Cell metabolism gene	RPL28	TOMM22	0.817730898	1.31E-12
DLBC	Cell metabolism gene	RPL28	POLR2J	0.821218876	8.73E-13
DLBC	Cell metabolism gene	RPL28	PPP2R1A	0.822894953	7.17E-13
DLBC	Cell metabolism gene	RPL28	TIMM9	0.827143819	4.31E-13
DLBC	Cell metabolism gene	RPL28	PSMC5	0.828845635	3.50E-13
DLBC	Cell metabolism gene	RPL28	POLR2F	0.833964315	1.84E-13
DLBC	Cell metabolism gene	RPL28	TIMM13	0.837670094	1.14E-13
DLBC	Cell metabolism gene	RPL28	PSMB3	0.841979863	6.47E-14
DLBC	Cell metabolism gene	RPL28	POLR2I	0.84921398	2.39E-14
DLBC	Cell metabolism gene	RPL28	NME2	0.869583942	1.07E-15
DLBC	Cell metabolism gene	RPL28	PFDN5	0.87261128	6.44E-16
DLBC	Cell metabolism gene	RPL28	SNRPD2	0.885578791	6.30E-17
DLBC	Cell metabolism gene	RPL28	FAU	0.891140809	2.13E-17
DLBC	CGC	RPL28	NACA	0.813316283	2.16E-12
DLBC	CGC	RPL28	PPP2R1A	0.822894953	7.17E-13
DLBC	Epifactor	RPL28	DMAP1	0.801654335	7.59E-12
DLBC	Epifactor	RPL28	ZNHIT1	0.805610058	5.00E-12
DLBC	Epifactor	RPL28	MBD3	0.817383417	1.36E-12
DLBC	Epifactor	RPL28	PRPF31	0.842044397	6.42E-14
DLBC	Epifactor	RPL28	FBL	0.869558634	1.07E-15
DLBC	IUPHAR	RPL28	MMP24	0.800123272	8.90E-12
DLBC	TF	RPL28	ZNF787	0.814468696	1.90E-12
DLBC	TF	RPL28	MBD3	0.817383417	1.36E-12
DLBC	TF	RPL28	THAP7	0.822428646	7.58E-13
DLBC	TF	RPL28	ZNF581	0.848408926	2.68E-14
DLBC	TF	RPL28	NME2	0.869583942	1.07E-15
DLBC	TF	RPL28	ZNF444	0.889012373	3.25E-17
DLBC	TSG	RPL28	GADD45GIP1	0.831375619	2.56E-13
DLBC	TSG	RPL28	GLTSCR2	0.841767487	6.66E-14
DLBC	TSG	RPL28	GNB2L1	0.86315155	3.01E-15
GBM	TF	RPL28	ZNF581	0.855784901	1.56E-50
HNSC	TF	RPL28	ZNF581	0.832880359	5.04E-147
KICH	Cell metabolism gene	RPL28	FAU	0.805849552	5.78E-22
KICH	Cell metabolism gene	RPL28	PGLS	0.811578865	1.74E-22
KICH	Cell metabolism gene	RPL28	SNRPD2	0.865679611	1.74E-28
KICH	Epifactor	RPL28	RUVBL2	0.827720181	4.71E-24
KICH	TF	RPL28	ZNF581	0.823860923	1.16E-23
KICH	TSG	RPL28	GLTSCR2	0.808533943	3.31E-22
KICH	TSG	RPL28	GADD45GIP1	0.81150161	1.77E-22
KIRP	Cell metabolism gene	RPL28	PGLS	0.838639702	1.06E-86
KIRP	Cell metabolism gene	RPL28	SNRPD2	0.853450315	7.38E-93
KIRP	Cell metabolism gene	RPL28	FAU	0.884082941	4.47E-108
KIRP	Epifactor	RPL28	SIRT6	0.800447253	2.47E-73
KIRP	Epifactor	RPL28	TAF10	0.801732178	9.79E-74
KIRP	IUPHAR	RPL28	SIRT6	0.800447253	2.47E-73
KIRP	TF	RPL28	ZNF787	0.803149254	3.51E-74
KIRP	TF	RPL28	DRAP1	0.808027697	9.58E-76
KIRP	TF	RPL28	ZNF581	0.833010494	1.61E-84
KIRP	TSG	RPL28	SIRT6	0.800447253	2.47E-73
KIRP	TSG	RPL28	GADD45GIP1	0.826388542	4.66E-82
LAML	Cell metabolism gene	RPL28	FAU	0.83625557	1.73E-46
LGG	TF	RPL28	ZNF581	0.857733739	1.09E-154
LIHC	Epifactor	RPL28	FBL	0.817642662	5.34E-103
LIHC	TF	RPL28	ZNF581	0.808245427	7.11E-99
LIHC	TSG	RPL28	GADD45GIP1	0.804694925	2.25E-97
MESO	Cell metabolism gene	RPL28	SNRPD2	0.810646908	1.85E-21
MESO	TF	RPL28	ZNF581	0.827215206	5.45E-23
MESO	TSG	RPL28	GLTSCR2	0.818980962	3.28E-22
OV	TF	RPL28	ZNF581	0.805128238	2.14E-71
PAAD	Cell metabolism gene	RPL28	FAU	0.819804738	1.08E-45
PAAD	TF	RPL28	ZNF581	0.832581416	2.59E-48
PCPG	Cell metabolism gene	RPL28	PGLS	0.800275883	5.91E-43
PCPG	Cell metabolism gene	RPL28	PFDN5	0.80386176	1.32E-43
PCPG	Cell metabolism gene	RPL28	SNRPD2	0.822265702	3.65E-47
PCPG	CGC	RPL28	MAP2K2	0.819811977	1.15E-46
PCPG	IUPHAR	RPL28	MAP2K2	0.819811977	1.15E-46
PCPG	Kinase	RPL28	MAP2K2	0.819811977	1.15E-46
PCPG	TF	RPL28	ZNF524	0.820757235	7.40E-47
PRAD	Cell metabolism gene	RPL28	POLR2F	0.812975041	8.35E-131
PRAD	Cell metabolism gene	RPL28	MPST	0.814045891	2.03E-131
PRAD	Cell metabolism gene	RPL28	NME2	0.818753689	3.65E-134
PRAD	Cell metabolism gene	RPL28	TIMM13	0.819756042	9.28E-135
PRAD	Cell metabolism gene	RPL28	PSMB7	0.829201298	1.49E-140
PRAD	Cell metabolism gene	RPL28	SNRPD2	0.848609336	1.16E-153
PRAD	Cell metabolism gene	RPL28	PGLS	0.850449659	5.35E-155
PRAD	Cell metabolism gene	RPL28	POLR2I	0.856316607	2.19E-159
PRAD	Cell metabolism gene	RPL28	FAU	0.861553482	1.79E-163
PRAD	Epifactor	RPL28	RUVBL2	0.812158869	2.44E-130
PRAD	Epifactor	RPL28	FBL	0.842820331	1.45E-149
PRAD	IUPHAR	RPL28	MPST	0.814045891	2.03E-131
PRAD	TF	RPL28	NME2	0.818753689	3.65E-134
PRAD	TF	RPL28	ZNF581	0.84556582	1.74E-151
PRAD	TF	RPL28	ZNF524	0.864418841	8.85E-166
PRAD	TSG	RPL28	GAS5	0.802813117	3.58E-125
PRAD	TSG	RPL28	GADD45GIP1	0.820281466	4.51E-135
PRAD	TSG	RPL28	GNB2L1	0.854840534	2.90E-158
READ	Cell metabolism gene	RPL28	SNRPD2	0.810277168	1.20E-25
TGCT	TSG	RPL28	GLTSCR2	0.84405311	1.60E-43
TGCT	TSG	RPL28	PDCD5	0.85338918	2.01E-45
THCA	Cell metabolism gene	RPL28	PGLS	0.817216153	1.56E-138
THCA	Cell metabolism gene	RPL28	GPX4	0.826970613	1.16E-144
THCA	Cell metabolism gene	RPL28	POLR2I	0.828021361	2.40E-145
THCA	Cell metabolism gene	RPL28	FAU	0.838459253	2.14E-152
THCA	Cell metabolism gene	RPL28	SNRPD2	0.86516302	5.45E-173
THCA	Epifactor	RPL28	C17orf49	0.800074867	1.33E-128
THCA	Epifactor	RPL28	SIRT6	0.822486916	8.48E-142
THCA	Epifactor	RPL28	TAF10	0.824566517	4.07E-143
THCA	IUPHAR	RPL28	SIRT6	0.822486916	8.48E-142
THCA	IUPHAR	RPL28	CSNK2B	0.840266058	1.14E-153
THCA	TF	RPL28	ZNF524	0.832341746	3.32E-148
THCA	TSG	RPL28	SIRT6	0.822486916	8.48E-142
THCA	TSG	RPL28	GNB2L1	0.839942158	1.94E-153
THYM	Cell metabolism gene	RPL28	DGAT1	0.800796099	1.74E-28
THYM	Cell metabolism gene	RPL28	TAZ	0.80202505	1.25E-28
THYM	Cell metabolism gene	RPL28	LSM3	0.802528632	1.09E-28
THYM	Cell metabolism gene	RPL28	UROS	0.803210445	9.07E-29
THYM	Cell metabolism gene	RPL28	PHPT1	0.80430144	6.73E-29
THYM	Cell metabolism gene	RPL28	NANS	0.805358472	5.03E-29
THYM	Cell metabolism gene	RPL28	GFER	0.805476774	4.87E-29
THYM	Cell metabolism gene	RPL28	SNRPB	0.805841735	4.40E-29
THYM	Cell metabolism gene	RPL28	HMBS	0.806818048	3.35E-29
THYM	Cell metabolism gene	RPL28	PSMB6	0.811396394	9.21E-30
THYM	Cell metabolism gene	RPL28	MTMR14	0.811491902	8.96E-30
THYM	Cell metabolism gene	RPL28	EXOSC1	0.812925873	5.93E-30
THYM	Cell metabolism gene	RPL28	GEMIN7	0.814204414	4.09E-30
THYM	Cell metabolism gene	RPL28	POLD4	0.814661054	3.58E-30
THYM	Cell metabolism gene	RPL28	PSMC1	0.815806409	2.56E-30
THYM	Cell metabolism gene	RPL28	PSMD4	0.815855604	2.53E-30
THYM	Cell metabolism gene	RPL28	GALK1	0.816539809	2.06E-30
THYM	Cell metabolism gene	RPL28	POLD2	0.816940511	1.83E-30
THYM	Cell metabolism gene	RPL28	SEC61G	0.817849719	1.40E-30
THYM	Cell metabolism gene	RPL28	SRM	0.818168754	1.27E-30
THYM	Cell metabolism gene	RPL28	MTX1	0.81865978	1.10E-30
THYM	Cell metabolism gene	RPL28	SEC61B	0.818806072	1.05E-30
THYM	Cell metabolism gene	RPL28	HSD17B10	0.820234921	6.85E-31
THYM	Cell metabolism gene	RPL28	OAZ1	0.822296241	3.66E-31
THYM	Cell metabolism gene	RPL28	TOMM22	0.82455268	1.83E-31
THYM	Cell metabolism gene	RPL28	APOA1	0.825877941	1.21E-31
THYM	Cell metabolism gene	RPL28	PFDN6	0.826485811	9.99E-32
THYM	Cell metabolism gene	RPL28	TBCB	0.826746983	9.20E-32
THYM	Cell metabolism gene	RPL28	PSME2	0.827014652	8.46E-32
THYM	Cell metabolism gene	RPL28	PAFAH1B3	0.828266139	5.69E-32
THYM	Cell metabolism gene	RPL28	TIMM10	0.830326617	2.95E-32
THYM	Cell metabolism gene	RPL28	TIMM17B	0.830447324	2.83E-32
THYM	Cell metabolism gene	RPL28	MIF	0.83177681	1.84E-32
THYM	Cell metabolism gene	RPL28	EXOSC5	0.833122519	1.19E-32
THYM	Cell metabolism gene	RPL28	TOMM40	0.834475887	7.60E-33
THYM	Cell metabolism gene	RPL28	GMPPA	0.835757818	4.96E-33
THYM	Cell metabolism gene	RPL28	DGUOK	0.837229179	3.03E-33
THYM	Cell metabolism gene	RPL28	UROD	0.837689088	2.59E-33
THYM	Cell metabolism gene	RPL28	FPGS	0.837903739	2.41E-33
THYM	Cell metabolism gene	RPL28	WBSCR22	0.838937522	1.70E-33
THYM	Cell metabolism gene	RPL28	ITPA	0.840214267	1.10E-33
THYM	Cell metabolism gene	RPL28	PGP	0.841156564	7.92E-34
THYM	Cell metabolism gene	RPL28	SMPD2	0.844955839	2.09E-34
THYM	Cell metabolism gene	RPL28	EXOSC4	0.84651627	1.19E-34
THYM	Cell metabolism gene	RPL28	LSM4	0.850642568	2.65E-35
THYM	Cell metabolism gene	RPL28	POLR2H	0.853397063	9.45E-36
THYM	Cell metabolism gene	RPL28	PSMB1	0.854287076	6.75E-36
THYM	Cell metabolism gene	RPL28	PSMB10	0.854579032	6.04E-36
THYM	Cell metabolism gene	RPL28	PSMD13	0.859140008	1.03E-36
THYM	Cell metabolism gene	RPL28	SSR2	0.859791728	7.94E-37
THYM	Cell metabolism gene	RPL28	EBP	0.862313883	2.89E-37
THYM	Cell metabolism gene	RPL28	LSM2	0.869554988	1.42E-38
THYM	Cell metabolism gene	RPL28	IDH3G	0.869766045	1.29E-38
THYM	Cell metabolism gene	RPL28	PSMC3	0.872403537	4.11E-39
THYM	Cell metabolism gene	RPL28	PHKG2	0.872663147	3.67E-39
THYM	Cell metabolism gene	RPL28	SNRPD3	0.874688487	1.49E-39
THYM	Cell metabolism gene	RPL28	MVD	0.874985941	1.31E-39
THYM	Cell metabolism gene	RPL28	SLC27A5	0.878365292	2.80E-40
THYM	Cell metabolism gene	RPL28	POLR2F	0.883155585	2.91E-41
THYM	Cell metabolism gene	RPL28	DPM2	0.887256381	3.87E-42
THYM	Cell metabolism gene	RPL28	GUK1	0.888913487	1.68E-42
THYM	Cell metabolism gene	RPL28	DPM3	0.889838207	1.04E-42
THYM	Cell metabolism gene	RPL28	ACOT8	0.890314857	8.16E-43
THYM	Cell metabolism gene	RPL28	TIMM8B	0.895045835	6.70E-44
THYM	Cell metabolism gene	RPL28	PSMB7	0.895151522	6.32E-44
THYM	Cell metabolism gene	RPL28	TIMM13	0.897394478	1.85E-44
THYM	Cell metabolism gene	RPL28	POLR2I	0.901206079	2.14E-45
THYM	Cell metabolism gene	RPL28	PFDN5	0.904205583	3.70E-46
THYM	Cell metabolism gene	RPL28	PSMB3	0.905208989	2.03E-46
THYM	Cell metabolism gene	RPL28	TIMM50	0.905601135	1.60E-46
THYM	Cell metabolism gene	RPL28	POLR2J	0.911545647	3.87E-48
THYM	Cell metabolism gene	RPL28	APRT	0.912810977	1.69E-48
THYM	Cell metabolism gene	RPL28	PGLS	0.92902832	1.20E-53
THYM	Cell metabolism gene	RPL28	SNRPD2	0.936233954	2.41E-56
THYM	Cell metabolism gene	RPL28	FAU	0.942207455	7.89E-59
THYM	CGC	RPL28	SDHAF2	0.840088513	1.14E-33
THYM	CGC	RPL28	MGMT	0.842630493	4.74E-34
THYM	CGC	RPL28	MAP2K2	0.856470045	2.92E-36
THYM	CGC	RPL28	RBM10	0.872985519	3.18E-39
THYM	CGC	RPL28	TFPT	0.910566135	7.27E-48
THYM	Epifactor	RPL28	PRMT7	0.802404843	1.13E-28
THYM	Epifactor	RPL28	EXOSC1	0.812925873	5.93E-30
THYM	Epifactor	RPL28	LAS1L	0.828046937	6.10E-32
THYM	Epifactor	RPL28	CXXC1	0.828680491	4.99E-32
THYM	Epifactor	RPL28	NOC2L	0.829472341	3.88E-32
THYM	Epifactor	RPL28	SS18L2	0.831554861	1.98E-32
THYM	Epifactor	RPL28	HIST2H2AC	0.831863567	1.79E-32
THYM	Epifactor	RPL28	EXOSC5	0.833122519	1.19E-32
THYM	Epifactor	RPL28	EXOSC4	0.84651627	1.19E-34
THYM	Epifactor	RPL28	DMAP1	0.846601347	1.16E-34
THYM	Epifactor	RPL28	ZGPAT	0.852259915	1.45E-35
THYM	Epifactor	RPL28	PAF1	0.854334489	6.63E-36
THYM	Epifactor	RPL28	MBD3	0.858880774	1.14E-36
THYM	Epifactor	RPL28	RUVBL2	0.86627156	5.68E-38
THYM	Epifactor	RPL28	PPP4C	0.866435109	5.31E-38
THYM	Epifactor	RPL28	C17orf49	0.881246792	7.26E-41
THYM	Epifactor	RPL28	FBL	0.885728183	8.28E-42
THYM	Epifactor	RPL28	INO80E	0.899165728	6.87E-45
THYM	Epifactor	RPL28	CCDC101	0.902807003	8.45E-46
THYM	Epifactor	RPL28	TFPT	0.910566135	7.27E-48
THYM	Epifactor	RPL28	SIRT6	0.913580988	1.02E-48
THYM	Epifactor	RPL28	PRPF31	0.913652107	9.70E-49
THYM	Epifactor	RPL28	BRMS1	0.922166803	2.47E-51
THYM	Epifactor	RPL28	ZNHIT1	0.937439669	7.96E-57
THYM	Epifactor	RPL28	TAF10	0.940730992	3.43E-58
THYM	IUPHAR	RPL28	DGAT1	0.800796099	1.74E-28
THYM	IUPHAR	RPL28	PRMT7	0.802404843	1.13E-28
THYM	IUPHAR	RPL28	SLC39A3	0.805472741	4.87E-29
THYM	IUPHAR	RPL28	RNPEPL1	0.806243222	3.94E-29
THYM	IUPHAR	RPL28	PSMB6	0.811396394	9.21E-30
THYM	IUPHAR	RPL28	CSNK2B	0.812443352	6.82E-30
THYM	IUPHAR	RPL28	SIRT3	0.814495752	3.76E-30
THYM	IUPHAR	RPL28	EGLN2	0.817247376	1.67E-30
THYM	IUPHAR	RPL28	ATG4B	0.820412327	6.49E-31
THYM	IUPHAR	RPL28	SMPD2	0.844955839	2.09E-34
THYM	IUPHAR	RPL28	PPIA	0.846346017	1.27E-34
THYM	IUPHAR	RPL28	PSMB1	0.854287076	6.75E-36
THYM	IUPHAR	RPL28	MAP2K2	0.856470045	2.92E-36
THYM	IUPHAR	RPL28	MMP24	0.857433337	2.01E-36
THYM	IUPHAR	RPL28	PHKG2	0.872663147	3.67E-39
THYM	IUPHAR	RPL28	MVD	0.874985941	1.31E-39
THYM	IUPHAR	RPL28	SLC27A5	0.878365292	2.80E-40
THYM	IUPHAR	RPL28	SIRT6	0.913580988	1.02E-48
THYM	Kinase	RPL28	MAP2K2	0.856470045	2.92E-36
THYM	Kinase	RPL28	PHKG2	0.872663147	3.67E-39
THYM	TF	RPL28	USF1	0.810876805	1.07E-29
THYM	TF	RPL28	ZNF653	0.813106238	5.63E-30
THYM	TF	RPL28	ZNF668	0.822146284	3.83E-31
THYM	TF	RPL28	ZNF581	0.826292898	1.06E-31
THYM	TF	RPL28	ZNF580	0.82836755	5.51E-32
THYM	TF	RPL28	SNAPC2	0.828395344	5.46E-32
THYM	TF	RPL28	CXXC1	0.828680491	4.99E-32
THYM	TF	RPL28	USF2	0.833397643	1.08E-32
THYM	TF	RPL28	ZNF32	0.84158176	6.83E-34
THYM	TF	RPL28	ZNF394	0.843715819	3.24E-34
THYM	TF	RPL28	GLI4	0.848212497	6.47E-35
THYM	TF	RPL28	ZGPAT	0.852259915	1.45E-35
THYM	TF	RPL28	THYN1	0.855081411	4.98E-36
THYM	TF	RPL28	AKAP8L	0.856055805	3.43E-36
THYM	TF	RPL28	THAP3	0.856362817	3.04E-36
THYM	TF	RPL28	IRF3	0.857068479	2.31E-36
THYM	TF	RPL28	MBD3	0.858880774	1.14E-36
THYM	TF	RPL28	ZNF444	0.859572682	8.67E-37
THYM	TF	RPL28	ETV2	0.86013202	6.94E-37
THYM	TF	RPL28	RBCK1	0.862513822	2.67E-37
THYM	TF	RPL28	ZNF688	0.873936047	2.09E-39
THYM	TF	RPL28	ZNF787	0.877548945	4.08E-40
THYM	TF	RPL28	ZNF524	0.878632831	2.47E-40
THYM	TF	RPL28	ZNF428	0.881562396	6.25E-41
THYM	TF	RPL28	THAP7	0.887292005	3.80E-42
THYM	TF	RPL28	DRAP1	0.888279963	2.31E-42
THYM	TSG	RPL28	ST20	0.811958424	7.84E-30
THYM	TSG	RPL28	SIRT3	0.814495752	3.76E-30
THYM	TSG	RPL28	HTRA2	0.820648887	6.04E-31
THYM	TSG	RPL28	ZNF668	0.822146284	3.83E-31
THYM	TSG	RPL28	AIP	0.834992768	6.40E-33
THYM	TSG	RPL28	PARK7	0.84023683	1.09E-33
THYM	TSG	RPL28	MAD1L1	0.842854814	4.38E-34
THYM	TSG	RPL28	GABARAP	0.843615775	3.35E-34
THYM	TSG	RPL28	PFN1	0.84406098	2.87E-34
THYM	TSG	RPL28	IRF3	0.857068479	2.31E-36
THYM	TSG	RPL28	TSSC4	0.887858832	2.86E-42
THYM	TSG	RPL28	NPRL2	0.896560081	2.93E-44
THYM	TSG	RPL28	GNB2L1	0.903492831	5.64E-46
THYM	TSG	RPL28	GADD45GIP1	0.909195098	1.74E-47
THYM	TSG	RPL28	SIRT6	0.913580988	1.02E-48
THYM	TSG	RPL28	GLTSCR2	0.915156115	3.54E-49
THYM	TSG	RPL28	BRMS1	0.922166803	2.47E-51
UCEC	Cell metabolism gene	RPL28	SNRPD2	0.80437468	7.02E-47
UCS	Cell metabolism gene	RPL28	DGAT1	0.800796099	1.74E-28
UCS	Cell metabolism gene	RPL28	TAZ	0.80202505	1.25E-28
UCS	Cell metabolism gene	RPL28	LSM3	0.802528632	1.09E-28
UCS	Cell metabolism gene	RPL28	UROS	0.803210445	9.07E-29
UCS	Cell metabolism gene	RPL28	PHPT1	0.80430144	6.73E-29
UCS	Cell metabolism gene	RPL28	NANS	0.805358472	5.03E-29
UCS	Cell metabolism gene	RPL28	GFER	0.805476774	4.87E-29
UCS	Cell metabolism gene	RPL28	SNRPB	0.805841735	4.40E-29
UCS	Cell metabolism gene	RPL28	HMBS	0.806818048	3.35E-29
UCS	Cell metabolism gene	RPL28	PSMB6	0.811396394	9.21E-30
UCS	Cell metabolism gene	RPL28	MTMR14	0.811491902	8.96E-30
UCS	Cell metabolism gene	RPL28	EXOSC1	0.812925873	5.93E-30
UCS	Cell metabolism gene	RPL28	GEMIN7	0.814204414	4.09E-30
UCS	Cell metabolism gene	RPL28	POLD4	0.814661054	3.58E-30
UCS	Cell metabolism gene	RPL28	PSMC1	0.815806409	2.56E-30
UCS	Cell metabolism gene	RPL28	PSMD4	0.815855604	2.53E-30
UCS	Cell metabolism gene	RPL28	GALK1	0.816539809	2.06E-30
UCS	Cell metabolism gene	RPL28	POLD2	0.816940511	1.83E-30
UCS	Cell metabolism gene	RPL28	SEC61G	0.817849719	1.40E-30
UCS	Cell metabolism gene	RPL28	SRM	0.818168754	1.27E-30
UCS	Cell metabolism gene	RPL28	MTX1	0.81865978	1.10E-30
UCS	Cell metabolism gene	RPL28	SEC61B	0.818806072	1.05E-30
UCS	Cell metabolism gene	RPL28	HSD17B10	0.820234921	6.85E-31
UCS	Cell metabolism gene	RPL28	OAZ1	0.822296241	3.66E-31
UCS	Cell metabolism gene	RPL28	TOMM22	0.82455268	1.83E-31
UCS	Cell metabolism gene	RPL28	APOA1	0.825877941	1.21E-31
UCS	Cell metabolism gene	RPL28	PFDN6	0.826485811	9.99E-32
UCS	Cell metabolism gene	RPL28	TBCB	0.826746983	9.20E-32
UCS	Cell metabolism gene	RPL28	PSME2	0.827014652	8.46E-32
UCS	Cell metabolism gene	RPL28	PAFAH1B3	0.828266139	5.69E-32
UCS	Cell metabolism gene	RPL28	TIMM10	0.830326617	2.95E-32
UCS	Cell metabolism gene	RPL28	TIMM17B	0.830447324	2.83E-32
UCS	Cell metabolism gene	RPL28	MIF	0.83177681	1.84E-32
UCS	Cell metabolism gene	RPL28	EXOSC5	0.833122519	1.19E-32
UCS	Cell metabolism gene	RPL28	TOMM40	0.834475887	7.60E-33
UCS	Cell metabolism gene	RPL28	GMPPA	0.835757818	4.96E-33
UCS	Cell metabolism gene	RPL28	DGUOK	0.837229179	3.03E-33
UCS	Cell metabolism gene	RPL28	UROD	0.837689088	2.59E-33
UCS	Cell metabolism gene	RPL28	FPGS	0.837903739	2.41E-33
UCS	Cell metabolism gene	RPL28	WBSCR22	0.838937522	1.70E-33
UCS	Cell metabolism gene	RPL28	ITPA	0.840214267	1.10E-33
UCS	Cell metabolism gene	RPL28	PGP	0.841156564	7.92E-34
UCS	Cell metabolism gene	RPL28	SMPD2	0.844955839	2.09E-34
UCS	Cell metabolism gene	RPL28	EXOSC4	0.84651627	1.19E-34
UCS	Cell metabolism gene	RPL28	LSM4	0.850642568	2.65E-35
UCS	Cell metabolism gene	RPL28	POLR2H	0.853397063	9.45E-36
UCS	Cell metabolism gene	RPL28	PSMB1	0.854287076	6.75E-36
UCS	Cell metabolism gene	RPL28	PSMB10	0.854579032	6.04E-36
UCS	Cell metabolism gene	RPL28	PSMD13	0.859140008	1.03E-36
UCS	Cell metabolism gene	RPL28	SSR2	0.859791728	7.94E-37
UCS	Cell metabolism gene	RPL28	EBP	0.862313883	2.89E-37
UCS	Cell metabolism gene	RPL28	LSM2	0.869554988	1.42E-38
UCS	Cell metabolism gene	RPL28	IDH3G	0.869766045	1.29E-38
UCS	Cell metabolism gene	RPL28	PSMC3	0.872403537	4.11E-39
UCS	Cell metabolism gene	RPL28	PHKG2	0.872663147	3.67E-39
UCS	Cell metabolism gene	RPL28	SNRPD3	0.874688487	1.49E-39
UCS	Cell metabolism gene	RPL28	MVD	0.874985941	1.31E-39
UCS	Cell metabolism gene	RPL28	SLC27A5	0.878365292	2.80E-40
UCS	Cell metabolism gene	RPL28	POLR2F	0.883155585	2.91E-41
UCS	Cell metabolism gene	RPL28	DPM2	0.887256381	3.87E-42
UCS	Cell metabolism gene	RPL28	GUK1	0.888913487	1.68E-42
UCS	Cell metabolism gene	RPL28	DPM3	0.889838207	1.04E-42
UCS	Cell metabolism gene	RPL28	ACOT8	0.890314857	8.16E-43
UCS	Cell metabolism gene	RPL28	TIMM8B	0.895045835	6.70E-44
UCS	Cell metabolism gene	RPL28	PSMB7	0.895151522	6.32E-44
UCS	Cell metabolism gene	RPL28	TIMM13	0.897394478	1.85E-44
UCS	Cell metabolism gene	RPL28	POLR2I	0.901206079	2.14E-45
UCS	Cell metabolism gene	RPL28	PFDN5	0.904205583	3.70E-46
UCS	Cell metabolism gene	RPL28	PSMB3	0.905208989	2.03E-46
UCS	Cell metabolism gene	RPL28	TIMM50	0.905601135	1.60E-46
UCS	Cell metabolism gene	RPL28	POLR2J	0.911545647	3.87E-48
UCS	Cell metabolism gene	RPL28	APRT	0.912810977	1.69E-48
UCS	Cell metabolism gene	RPL28	PGLS	0.92902832	1.20E-53
UCS	Cell metabolism gene	RPL28	SNRPD2	0.936233954	2.41E-56
UCS	Cell metabolism gene	RPL28	FAU	0.942207455	7.89E-59
UCS	CGC	RPL28	SDHAF2	0.840088513	1.14E-33
UCS	CGC	RPL28	MGMT	0.842630493	4.74E-34
UCS	CGC	RPL28	MAP2K2	0.856470045	2.92E-36
UCS	CGC	RPL28	RBM10	0.872985519	3.18E-39
UCS	CGC	RPL28	TFPT	0.910566135	7.27E-48
UCS	Epifactor	RPL28	PRMT7	0.802404843	1.13E-28
UCS	Epifactor	RPL28	EXOSC1	0.812925873	5.93E-30
UCS	Epifactor	RPL28	LAS1L	0.828046937	6.10E-32
UCS	Epifactor	RPL28	CXXC1	0.828680491	4.99E-32
UCS	Epifactor	RPL28	NOC2L	0.829472341	3.88E-32
UCS	Epifactor	RPL28	SS18L2	0.831554861	1.98E-32
UCS	Epifactor	RPL28	HIST2H2AC	0.831863567	1.79E-32
UCS	Epifactor	RPL28	EXOSC5	0.833122519	1.19E-32
UCS	Epifactor	RPL28	EXOSC4	0.84651627	1.19E-34
UCS	Epifactor	RPL28	DMAP1	0.846601347	1.16E-34
UCS	Epifactor	RPL28	ZGPAT	0.852259915	1.45E-35
UCS	Epifactor	RPL28	PAF1	0.854334489	6.63E-36
UCS	Epifactor	RPL28	MBD3	0.858880774	1.14E-36
UCS	Epifactor	RPL28	RUVBL2	0.86627156	5.68E-38
UCS	Epifactor	RPL28	PPP4C	0.866435109	5.31E-38
UCS	Epifactor	RPL28	C17orf49	0.881246792	7.26E-41
UCS	Epifactor	RPL28	FBL	0.885728183	8.28E-42
UCS	Epifactor	RPL28	INO80E	0.899165728	6.87E-45
UCS	Epifactor	RPL28	CCDC101	0.902807003	8.45E-46
UCS	Epifactor	RPL28	TFPT	0.910566135	7.27E-48
UCS	Epifactor	RPL28	SIRT6	0.913580988	1.02E-48
UCS	Epifactor	RPL28	PRPF31	0.913652107	9.70E-49
UCS	Epifactor	RPL28	BRMS1	0.922166803	2.47E-51
UCS	Epifactor	RPL28	ZNHIT1	0.937439669	7.96E-57
UCS	Epifactor	RPL28	TAF10	0.940730992	3.43E-58
UCS	IUPHAR	RPL28	DGAT1	0.800796099	1.74E-28
UCS	IUPHAR	RPL28	PRMT7	0.802404843	1.13E-28
UCS	IUPHAR	RPL28	SLC39A3	0.805472741	4.87E-29
UCS	IUPHAR	RPL28	RNPEPL1	0.806243222	3.94E-29
UCS	IUPHAR	RPL28	PSMB6	0.811396394	9.21E-30
UCS	IUPHAR	RPL28	CSNK2B	0.812443352	6.82E-30
UCS	IUPHAR	RPL28	SIRT3	0.814495752	3.76E-30
UCS	IUPHAR	RPL28	EGLN2	0.817247376	1.67E-30
UCS	IUPHAR	RPL28	ATG4B	0.820412327	6.49E-31
UCS	IUPHAR	RPL28	SMPD2	0.844955839	2.09E-34
UCS	IUPHAR	RPL28	PPIA	0.846346017	1.27E-34
UCS	IUPHAR	RPL28	PSMB1	0.854287076	6.75E-36
UCS	IUPHAR	RPL28	MAP2K2	0.856470045	2.92E-36
UCS	IUPHAR	RPL28	MMP24	0.857433337	2.01E-36
UCS	IUPHAR	RPL28	PHKG2	0.872663147	3.67E-39
UCS	IUPHAR	RPL28	MVD	0.874985941	1.31E-39
UCS	IUPHAR	RPL28	SLC27A5	0.878365292	2.80E-40
UCS	IUPHAR	RPL28	SIRT6	0.913580988	1.02E-48
UCS	Kinase	RPL28	MAP2K2	0.856470045	2.92E-36
UCS	Kinase	RPL28	PHKG2	0.872663147	3.67E-39
UCS	TF	RPL28	USF1	0.810876805	1.07E-29
UCS	TF	RPL28	ZNF653	0.813106238	5.63E-30
UCS	TF	RPL28	ZNF668	0.822146284	3.83E-31
UCS	TF	RPL28	ZNF581	0.826292898	1.06E-31
UCS	TF	RPL28	ZNF580	0.82836755	5.51E-32
UCS	TF	RPL28	SNAPC2	0.828395344	5.46E-32
UCS	TF	RPL28	CXXC1	0.828680491	4.99E-32
UCS	TF	RPL28	USF2	0.833397643	1.08E-32
UCS	TF	RPL28	ZNF32	0.84158176	6.83E-34
UCS	TF	RPL28	ZNF394	0.843715819	3.24E-34
UCS	TF	RPL28	GLI4	0.848212497	6.47E-35
UCS	TF	RPL28	ZGPAT	0.852259915	1.45E-35
UCS	TF	RPL28	THYN1	0.855081411	4.98E-36
UCS	TF	RPL28	AKAP8L	0.856055805	3.43E-36
UCS	TF	RPL28	THAP3	0.856362817	3.04E-36
UCS	TF	RPL28	IRF3	0.857068479	2.31E-36
UCS	TF	RPL28	MBD3	0.858880774	1.14E-36
UCS	TF	RPL28	ZNF444	0.859572682	8.67E-37
UCS	TF	RPL28	ETV2	0.86013202	6.94E-37
UCS	TF	RPL28	RBCK1	0.862513822	2.67E-37
UCS	TF	RPL28	ZNF688	0.873936047	2.09E-39
UCS	TF	RPL28	ZNF787	0.877548945	4.08E-40
UCS	TF	RPL28	ZNF524	0.878632831	2.47E-40
UCS	TF	RPL28	ZNF428	0.881562396	6.25E-41
UCS	TF	RPL28	THAP7	0.887292005	3.80E-42
UCS	TF	RPL28	DRAP1	0.888279963	2.31E-42
UCS	TSG	RPL28	ST20	0.811958424	7.84E-30
UCS	TSG	RPL28	SIRT3	0.814495752	3.76E-30
UCS	TSG	RPL28	HTRA2	0.820648887	6.04E-31
UCS	TSG	RPL28	ZNF668	0.822146284	3.83E-31
UCS	TSG	RPL28	AIP	0.834992768	6.40E-33
UCS	TSG	RPL28	PARK7	0.84023683	1.09E-33
UCS	TSG	RPL28	MAD1L1	0.842854814	4.38E-34
UCS	TSG	RPL28	GABARAP	0.843615775	3.35E-34
UCS	TSG	RPL28	PFN1	0.84406098	2.87E-34
UCS	TSG	RPL28	IRF3	0.857068479	2.31E-36
UCS	TSG	RPL28	TSSC4	0.887858832	2.86E-42
UCS	TSG	RPL28	NPRL2	0.896560081	2.93E-44
UCS	TSG	RPL28	GNB2L1	0.903492831	5.64E-46
UCS	TSG	RPL28	GADD45GIP1	0.909195098	1.74E-47
UCS	TSG	RPL28	SIRT6	0.913580988	1.02E-48
UCS	TSG	RPL28	GLTSCR2	0.915156115	3.54E-49
UCS	TSG	RPL28	BRMS1	0.922166803	2.47E-51
UVM	Cell metabolism gene	RPL28	PAFAH1B3	0.809943012	9.30E-20
UVM	Cell metabolism gene	RPL28	DOHH	0.809974227	9.25E-20
UVM	Cell metabolism gene	RPL28	POLR2I	0.818975525	1.67E-20
UVM	Cell metabolism gene	RPL28	MPST	0.820066907	1.35E-20
UVM	Cell metabolism gene	RPL28	PGLS	0.836649454	4.35E-22
UVM	Cell metabolism gene	RPL28	SSR2	0.846122362	5.12E-23
UVM	Cell metabolism gene	RPL28	PRKCSH	0.865790783	3.65E-25
UVM	Cell metabolism gene	RPL28	FAU	0.877248362	1.41E-26
UVM	CGC	RPL28	MAP2K2	0.842245695	1.25E-22
UVM	CGC	RPL28	TRAF7	0.85703891	3.61E-24
UVM	Epifactor	RPL28	BRMS1	0.817087202	2.41E-20
UVM	Epifactor	RPL28	CCDC101	0.828877649	2.28E-21
UVM	Epifactor	RPL28	FBL	0.87685006	1.59E-26
UVM	Epifactor	RPL28	TRIM28	0.882726997	2.65E-27
UVM	IUPHAR	RPL28	MAP3K11	0.811519871	6.94E-20
UVM	IUPHAR	RPL28	MPST	0.820066907	1.35E-20
UVM	IUPHAR	RPL28	MAP2K2	0.842245695	1.25E-22
UVM	IUPHAR	RPL28	TRIM28	0.882726997	2.65E-27
UVM	Kinase	RPL28	MAP3K11	0.811519871	6.94E-20
UVM	Kinase	RPL28	MAP2K2	0.842245695	1.25E-22
UVM	Kinase	RPL28	TRIM28	0.882726997	2.65E-27
UVM	TF	RPL28	ETV2	0.807148033	1.55E-19
UVM	TF	RPL28	ZNF205	0.810875352	7.83E-20
UVM	TF	RPL28	ZNF579	0.82656329	3.67E-21
UVM	TF	RPL28	FIZ1	0.850513296	1.81E-23
UVM	TF	RPL28	ZNF787	0.851353597	1.47E-23
UVM	TF	RPL28	ZNF581	0.868751318	1.62E-25
UVM	TF	RPL28	ZNF358	0.87323214	4.57E-26
UVM	TF	RPL28	ZNF524	0.882846289	2.55E-27
UVM	TSG	RPL28	AIP	0.80911059	1.08E-19
UVM	TSG	RPL28	BRMS1	0.817087202	2.41E-20
UVM	TSG	RPL28	GLTSCR2	0.823774371	6.47E-21
UVM	TSG	RPL28	GNB2L1	0.840640532	1.80E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL28	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL28	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL28	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL28	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL28	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL28	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL28	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL28	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL28	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL28	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL28	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL28	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL28	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL28	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL28	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL28	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL28	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL28	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL28	RPS23	-2.03658159814007	0.046875
KIRC	RPL28	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL28	RPS12	-4.91239327478244	1.85340619742495e-09
KIRC	RPL28	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL28	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL28	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL28	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL28	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPL28	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL28	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL28	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL28

MAGEB2, UBC, DCC, ARRB2, TDRD3, CUL2, CDK2, CUL1, COPS5, CAND1, ESR1, MAGOH, EIF4A3, PA2G4, FN1, SMAD4, UBL4A, ITGA4, PAN2, MAP2K5, FBXO6, TARDBP, GTF2I, RPL8, RPS10, RPS18, RPS19, RPS23, RPS29, RPS2, RPS3A, RPS3, GRSF1, TP53, PCSK9, CCNDBP1, BRCA1, CCDC8, RNF2, RPL23A, RPL13, RPL14, RPL19, RPL21, RPL23, RPL3, RPL34, RPL36, RPL5, RPL7, RPLP0, RPS11, RPS14, RPS15, RPS15A, RPS16, RPS25, RPL35, RPL38, RPLP1, RPLP2, RPS6, gag, XPO1, HNRNPU, KIF11, Srp72, Gtf3c2, MCM2, Ksr1, RC3H1, C3orf17, ZNF746, HIST1H1D, HIST1H1A, HIST1H1C, PTPRK, KLHL21, FAT4, ZDBF2, GSG2, FAT3, SIPA1L2, KIAA0020, TRO, KIAA0232, CDC42BPA, TUBB3, RPL18A, IFFO1, RRP8, CELSR2, FREM2, RBM34, AKAP11, PLCH1, RPL4, RPL26L1, PPAN-P2RY11, POLE2, GLYR1, ZNF354A, WHSC1, ZCCHC7, C1QBP, FTSJ3, POLE, ZNF644, BRIX1, RPL32, PTPRD, RPL30, RPL27, TUBA4A, DKC1, RPL18, GPR98, RPL6, ZNF184, CENPU, GPRASP2, RBM28, SDCBP, RPL7A, PEX14, ZNF865, KLHL15, RPS8, NCL, CYLD, INO80B, COX15, DNM1L, PDHA1, SOAT1, VDAC1, FOXA1, TRIM25, MTF1, CFTR, ANAPC13, FAM98B, CEP295, KIF14, PAFAH1B1, PTTG1, PWP1, RPF2, TAF2, TCOF1, ZNF830, HBP1, PPP1CC, WDR77, MATN2, API5, BMP4, CTNNB1, JUP, MAP2K3, PCBP1, PPIE, TRIP4, PIH1D1, EFTUD2, CHD3, TNF, RIOK1, MEPCE, LARP7, AGR2, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, C1orf106, GRWD1, RC3H2, ZBTB7A, PHB, RBX1, NR2C2, CTCF, DYNC1I1, DYNC1I2, DCTN4, VRK1, HIST1H4A, SNRNP70, PTPN21, ITFG1, ARAF, BIRC3, NFX1, WWP2, MATR3, CMTR1, PLEKHA4, PINK1, FANCD2, PTEN, HCVgp1, ZC3H18, MAP3K14, PTPN6, RAB5A, SRP14, M, nsp13, nsp4, nsp5, nsp6, ORF7a, ORF14, ORF8, S, MAP1LC3B, CIT, ANLN, CHMP4C, ECT2, KIF20A, KIF23, INS, NDN, BRD4, Apc2, RBM39, FBP1, LGALS9, BKRF1, USP15, DNAJC1, DNAJC2, TRIM37, PARK2, UFL1, DDRGK1, DHFRL1, PANX1, POLR2C, PTK2, PAGE4, NAA40, ZNF483, RSL1D1, ZNF770, PRKRA, PRPF4B, NSUN4, DDX21, URB2, PAK1IP1, BMS1, NOC3L, TTF1, DDX18, NOP2, COASY, ZCCHC6, GTF3C1, GTF3C2, CENPT, NSA2, DDX31, ZNF121, MAK16, TAF1C, TAF1B, TAF1A, ZNF629, SDAD1, PRDM15, CENPO, SLC4A7, GTPBP10, DDX54, PDCD11, LENG8, DDX24, NVL, CEBPZ, CDKN2AIP, ZC3HAV1, RPL11, RPL9, RPL17, YTHDC2, ZNF777, SCAF1, EBNA1BP2, ZNF771, ZNF445, GZF1, CDK12, NLE1, CENPH, DDX27, TRMT1L, NIP7, CENPN, ZFP62, HNRNPLL, RPF1, DDX55, ZNF317, REXO4, APOBEC3C, RSBN1, DDX51, CENPC, CCDC106, TAF1D, RPL36AL, SRRM1, NOC2L, ZNF624, ZNF70, DHX35, CENPP, BBX, MYBBP1A, GTPBP4, RRP1B, DDX50, SURF6, BUD13, SRPK2, ASH1L, DNTTIP2, WDR12, RRS1, ZNF724P, ZNF397, ZNF768, CENPQ, SRPK1, SRP68, SRP72, ITGB3BP, SPTY2D1, ZC3H10, NOL8, ZCCHC17, URB1, SRBD1, ZNF189, RPL37A, PAPD5, ZNF22, LBR, STAU2, CMAS, ZNF512, RSL24D1, DDX56, MCM3AP, C7orf50, STAU1, CDC42BPG, WDR74, RPL7L1, C12orf43, TUBA8, RRP15, FAM111A, NIFK, SPRTN, BTF3, FBXW7, NLRP7, DPP4, RCHY1, CCNF, KLF12, KLF3, KLF15, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL28	chr19	55903002	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL28	chr19	55912909	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL28	chr19	55912946	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL28	chr19	55912969	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL28	chr19	55912978	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL28	PRAD	chr19	55898050	55898050	A	T	Missense_Mutation	p.K65M	3
RPL28	ESCA	chr19	55899415	55899415	T	C	Missense_Mutation	p.M108T	3
RPL28	PAAD	chr19	55899621	55899621	G	A	Missense_Mutation	p.R112H	3
RPL28	PAAD	chr19	55899358	55899358	C	T	Missense_Mutation	p.T89M	3
RPL28	STAD	chr19	55899351	55899351	C	T	Missense_Mutation	p.R87C	2
RPL28	ESCA	chr19	55899415	55899415	T	C	Missense_Mutation		2
RPL28	BLCA	chr19	55897738	55897738	C	G	Missense_Mutation	p.L5V	2
RPL28	BLCA	chr19	55899468	55899468	G	A	Missense_Mutation	p.E126K	2
RPL28	SARC	chr19	55898033	55898033	T	G	Silent		2
RPL28	LUAD	chr19	55897779	55897779	C	G	Missense_Mutation	p.I18M	2
RPL28	UCEC	chr19	55897789	55897789	A	G	Missense_Mutation	p.K22E	2
RPL28	UCEC	chr19	55899311	55899311	T	C	Silent	p.P73	2
RPL28	UCEC	chr19	55899675	55899675	G	A	Missense_Mutation	p.R130Q	2
RPL28	STAD	chr19	55899351	55899351	C	T	Missense_Mutation		2
RPL28	UCEC	chr19	55902965	55902965	C	T	Missense_Mutation	p.A123V	2
RPL28	BLCA	chr19	55899468	55899468	G	A	Missense_Mutation		1
RPL28	LIHC	chr19	55902977	55902977	G	-	Frame_Shift_Del	p.W127fs	1
RPL28	BLCA	chr19	55898022	55898022	G	A	Missense_Mutation	p.D56N	1
RPL28	PRAD	chr19	55899546	55899546	C	T	Missense_Mutation	p.H152Y	1
RPL28	STAD	chr19	55899503	55899503	G	A	Nonsense_Mutation	p.W137X	1
RPL28	LUAD	chr19	55899329	55899329	G	T	Missense_Mutation	p.G73V	1
RPL28	READ	chr19	55899632	55899632	G	A	Missense_Mutation	p.A116T	1
RPL28	ESCA	chr19	55897713	55897713	C	T	Missense_Mutation		1
RPL28	STAD	chr19	55899503	55899503	G	A	Nonsense_Mutation	p.W137*	1
RPL28	LUAD	chr19	55898026	55898026	G	A	Missense_Mutation	p.G57D	1
RPL28	HNSC	chr19	55899356	55899356	C	T	Missense_Mutation		1
RPL28	STAD	chr19	55899400	55899400	G	A	Missense_Mutation	p.R103H	1
RPL28	CESC	chr19	55898086	55898086	G	C	Missense_Mutation		1
RPL28	SARC	chr19	55898033	55898033	T	G	Silent	p.G59G	1
RPL28	HNSC	chr19	55899356	55899356	C	T	Silent	p.A88A	1
RPL28	STAD	chr19	55897997	55897997	G	C	Missense_Mutation	p.K47N	1
RPL28	LUAD	chr19	55898082	55898082	G	A	Missense_Mutation	p.A76T	1
RPL28	CESC	chr19	55899505	55899505	G	A	Missense_Mutation		1
RPL28	SARC	chr19	55897999	55897999	C	T	Missense_Mutation		1
RPL28	KIRC	chr19	55899365	55899365	C	G	Missense_Mutation	p.S91R	1
RPL28	STAD	chr19	55899503	55899503	G	A	Nonsense_Mutation		1
RPL28	LUAD	chr19	55899329	55899329	G	T	Silent	p.R79R	1
RPL28	SARC	chr19	55898033	55898033	T	G	Silent	p.G59	1
RPL28	CESC	chr19	55898086	55898086	G	C	Missense_Mutation	p.R77T	1
RPL28	KIRP	chr19	55897936	55897936	A	G	Splice_Site	.	1
RPL28	UCEC	chr19	55899311	55899311	T	C	Silent	p.P73P	1
RPL28	LUSC	chr19	55899328	55899328	G	T	Missense_Mutation	p.R79L	1
RPL28	CESC	chr19	55899502	55899502	G	A	Nonsense_Mutation	p.W137*	1
RPL28	SKCM	chr19	55899332	55899332	C	T	Silent	p.T80T	1
RPL28	KIRP	chr19	55897758	55897758	G	T	Silent		1
RPL28	PAAD	chr19	55899358	55899358	C	T	Missense_Mutation		1
RPL28	CESC	chr19	55899505	55899505	G	A	Missense_Mutation	p.R138K	1
RPL28	SKCM	chr19	55897966	55897966	C	T	Missense_Mutation	p.S37F	1
RPL28	LIHC	chr19	55899324	55899324	G	A	Missense_Mutation	p.V78M	1
RPL28	BLCA	chr19	55898022	55898022	G	A	Missense_Mutation		1
RPL28	CESC	chr19	55899664	55899664	G	A	Silent	p.V126	1
RPL28	SKCM	chr19	55899332	55899332	C	T	Missense_Mutation	p.P74L	1
RPL28	LIHC	chr19	55899577	55899578	-	G	Frame_Shift_Ins	p.R162fs	1
RPL28	BLCA	chr19	55897738	55897738	C	G	Missense_Mutation		1
RPL28	COAD	chr19	55897765	55897765	T	C	Missense_Mutation	p.S14P	1
RPL28	LIHC	chr19	55898098	55898098	T	-	Frame_Shift_Del	p.L81fs	1

Copy number variation (CNV) of RPL28
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL28
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103062	COAD	TCGA-AA-A01R-01A	ACIN1	chr14	23564688	-	RPL28	chr19	55899687	+
103062	STAD	TCGA-VQ-A8PJ-01A	AKAP8	chr19	15465660	-	RPL28	chr19	55897718	+
103062	STAD	TCGA-VQ-A8PJ-01A	AKAP8	chr19	15466118	-	RPL28	chr19	55897718	+
103062	N/A	BU543829	ANGPTL4	chr19	8436347	-	RPL28	chr19	55897312	+
103062	STAD	TCGA-IN-7808-01A	CDC42EP5	chr19	54982766	-	RPL28	chr19	55897718	+
103062	N/A	BM144240	COL14A1	chr8	121293326	+	RPL28	chr19	55903460	-
103062	N/A	BG473709	DDX1	chr2	15760492	-	RPL28	chr19	55897300	+
103062	LUSC	TCGA-22-5478	GATAD2A	chr19	19496947	+	RPL28	chr19	55887279	+
103062	LUSC	TCGA-22-5478	GATAD2A	chr19	19496947	+	RPL28	chr19	55897717	+
103062	LUSC	TCGA-22-5478	GATAD2A	chr19	19496947	+	RPL28	chr19	55897718	+
103062	LUSC	TCGA-22-5478-01A	GATAD2A	chr19	19516828	+	RPL28	chr19	55897718	+
103062	ESCA	TCGA-L5-A43M	GPC1	chr2	241392439	+	RPL28	chr19	55897716	+
103062	STAD	TCGA-BR-8487	MYL12A	chr18	3247907	+	RPL28	chr19	55897717	+
103062	N/A	AA533511	NARS	chr18	55284177	-	RPL28	chr19	55899741	-
103062	N/A	BQ653766	NONO	chrX	70517282	+	RPL28	chr19	55899686	+
103062	SKCM	TCGA-D3-A1Q4-06A	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
103062	SKCM	TCGA-D3-A1Q4-06A	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
103062	Non-Cancer	TCGA-E9-A1R7-11A	REV3L	chr6	111804150	-	RPL28	chr19	55897726	+
103062	N/A	AA308428	REV3L	chr6	111804150	-	RPL28	chr19	55897716	+
99545	N/A	BG034598	RPL28	chr19	55899741	+	AHCYL2	chr7	128909148	-
94477	N/A	BP283815	RPL28	chr19	55899761	+	ALDOA	chr16	30077085	+
76387	N/A	EC567947	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
99059	N/A	DB253394	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
102441	GBM	TCGA-06-2559-01A	RPL28	chr19	55898061	+	CCDC106	chr19	56160774	+
97707	N/A	BG031684	RPL28	chr19	55899741	+	EGLN3	chr14	34757427	-
89904	N/A	AA776201	RPL28	chr19	55899611	-	EPB41L1	chr20	34776411	-
77753	UCEC	TCGA-BG-A0M7-01A	RPL28	chr19	55899416	+	FAM159B	chr5	63986324	+
100329	N/A	BG576406	RPL28	chr19	55899741	+	FBXO42	chr1	16662875	-
103040	N/A	AW498880	RPL28	chr19	55899730	+	GAPDH	chr12	6644002	+
101967	N/A	DA524376	RPL28	chr19	55899416	+	GLB1	chr3	33114206	-
86024	N/A	AA532953	RPL28	chr19	55899738	+	GLCE	chr15	69555786	-
94142	LUSC	TCGA-94-8491-01A	RPL28	chr19	55897806	+	GSE1	chr16	85391069	+
76387	N/A	AV686476	RPL28	chr19	55899670	+	IFT122	chr3	129192608	+
97776	N/A	BP226247	RPL28	chr19	55899745	+	KDM6A	chrX	44755889	-
94425	N/A	BE387849	RPL28	chr19	55897775	+	LASP1	chr17	37076280	+
103042	N/A	AA525080	RPL28	chr19	55899741	+	LMX1B	chr9	129425696	+
92542	N/A	BI861441	RPL28	chr19	55899741	+	PCCA	chr13	100834041	-
103062	N/A	AA166763	RPL28	chr19	55899685	-	RPL28	chr19	55899660	+
103062	N/A	AA166944	RPL28	chr19	55899660	-	RPL28	chr19	55899685	+
103062	N/A	AI907286	RPL28	chr19	55898013	+	RPL28	chr19	55899360	-
97459	STAD	TCGA-BR-A4PD-01A	RPL28	chr19	55899416	+	SOD1	chr21	33036103	+
98914	N/A	BE907624	RPL28	chr19	55899741	+	TECPR2	chr14	102942540	+
92537	N/A	BP430996	RPL28	chr19	55899743	+	TMTC3	chr12	88560791	-
103062	N/A	BQ646046	RRN3	chr16	15169104	-	RPL28	chr19	55899743	-
103062	N/A	AA543104	SMG6	chr17	2200292	-	RPL28	chr19	55899741	-
103062	N/A	BG273006	TBC1D5	chr3	18344594	+	RPL28	chr19	55899746	-
103062	N/A	BF342124	TRMT112	chr11	64084929	-	RPL28	chr19	55899702	+
103062	N/A	BQ645838	TSC22D3	chrX	106993491	+	RPL28	chr19	55899743	-
103062	N/A	CB050940	TTTY1B	chrY	6279351	+	RPL28	chr19	55899746	-
103062	STAD	TCGA-HU-A4GN-01A	XPO7	chr8	21777299	+	RPL28	chr19	55897718	+
103064	OV	TCGA-13-0916-01A	ZNF844	chr19	12175691	+	RPL28	chr19	55914311	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPL28	0.0106323631670599	0.3
KIRC	RPL28	0.0215195312355118	0.58

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPL28	0.0201180650660518	0.64
LUSC	RPL28	0.0475649229041292	1
PAAD	RPL28	0.0140907074372425	0.46
THYM	RPL28	0.0393350547481049	1
SARC	RPL28	0.0358399870277739	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source