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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS16 (NCBI Gene ID:6217)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS16
	Gene ID: 6217
	Gene Symbol	RPS16
	Gene ID	6217
	Gene Name	ribosomal protein S16
	Synonyms	S16
	Cytomap	19q13.2
	Type of Gene	protein-coding
	Description	40S ribosomal protein S16small ribosomal subunit protein uS9
	Modification date	20200313
	UniProtAcc	P62249

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS16	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS16[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS16	Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae	24948608

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000251453	39924161	39924209	In-frame
ENST00000251453	39924304	39924401	Frame-shift
ENST00000251453	39926246	39926348	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000251453	39924161	39924209	577	301	348	146	82	98
ENST00000251453	39926246	39926348	577	102	203	146	16	50

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62249	82	98	2	146	Chain	ID=PRO_0000111479;Note=40S ribosomal protein S16
P62249	16	50	2	146	Chain	ID=PRO_0000111479;Note=40S ribosomal protein S16

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	RPS16	-1.35957043617517	0.00019507110118866
THCA	RPS16	-6.16322798156577	0.0115764821363307
KIRC	RPS16	-1.66149869889384	7.8509870430991e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	RPS16	-0.061601907	0.021636014
CESC	RPS16	0.047556121	0.03780426

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS16 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Epifactor	RPS16	FBL	0.825782817	7.69E-21
BLCA	Epifactor	RPS16	FBL	0.82352138	1.92E-106
BRCA	Epifactor	RPS16	FBL	0.840805725	0
CHOL	Cell metabolism gene	RPS16	EXOSC5	0.800004917	4.31E-11
CHOL	Cell metabolism gene	RPS16	SNRPD2	0.887576641	4.54E-16
CHOL	CGC	RPS16	NACA	0.830107192	1.78E-12
CHOL	Epifactor	RPS16	EXOSC5	0.800004917	4.31E-11
CHOL	Epifactor	RPS16	FBL	0.889135708	3.42E-16
CHOL	TSG	RPS16	GNB2L1	0.807819725	1.99E-11
COAD	Cell metabolism gene	RPS16	SNRPD2	0.823691216	1.44E-82
DLBC	Cell metabolism gene	RPS16	GFER	0.801300402	7.88E-12
DLBC	Cell metabolism gene	RPS16	POLR2J	0.820879993	9.09E-13
DLBC	Cell metabolism gene	RPS16	TIMM13	0.821123163	8.83E-13
DLBC	Cell metabolism gene	RPS16	POLR2F	0.829583575	3.19E-13
DLBC	Cell metabolism gene	RPS16	TIMM9	0.845376053	4.08E-14
DLBC	Cell metabolism gene	RPS16	TOMM22	0.846003962	3.74E-14
DLBC	Cell metabolism gene	RPS16	GEMIN7	0.846130601	3.68E-14
DLBC	Cell metabolism gene	RPS16	NME2	0.856498349	8.32E-15
DLBC	Cell metabolism gene	RPS16	PFDN5	0.858158125	6.48E-15
DLBC	Cell metabolism gene	RPS16	SNRPD2	0.885131533	6.86E-17
DLBC	Cell metabolism gene	RPS16	FAU	0.893643744	1.28E-17
DLBC	CGC	RPS16	NACA	0.874007105	5.08E-16
DLBC	Epifactor	RPS16	FBL	0.873756204	5.30E-16
DLBC	TF	RPS16	ZNF581	0.829609245	3.18E-13
DLBC	TF	RPS16	NME2	0.856498349	8.32E-15
DLBC	TSG	RPS16	GLTSCR2	0.823897308	6.36E-13
DLBC	TSG	RPS16	GADD45GIP1	0.829422883	3.26E-13
DLBC	TSG	RPS16	GNB2L1	0.910019264	3.29E-19
GBM	Cell metabolism gene	RPS16	GEMIN7	0.806767441	1.08E-40
GBM	Cell metabolism gene	RPS16	PFDN5	0.807785498	7.19E-41
GBM	Cell metabolism gene	RPS16	SSR2	0.818407845	9.31E-43
GBM	Cell metabolism gene	RPS16	LSM2	0.822069449	1.95E-43
GBM	Cell metabolism gene	RPS16	ZNRD1	0.823936775	8.64E-44
GBM	Cell metabolism gene	RPS16	FAU	0.850488473	2.64E-49
GBM	Cell metabolism gene	RPS16	SNRPD2	0.874738551	2.28E-55
KICH	Cell metabolism gene	RPS16	SNRPD2	0.810755147	2.07E-22
KIRP	Cell metabolism gene	RPS16	FAU	0.86766424	1.92E-99
KIRP	Cell metabolism gene	RPS16	SNRPD2	0.8957653	4.69E-115
KIRP	Epifactor	RPS16	FBL	0.856487025	3.32E-94
KIRP	TF	RPS16	ZNF581	0.807730523	1.20E-75
KIRP	TSG	RPS16	GNB2L1	0.813521615	1.47E-77
LAML	Cell metabolism gene	RPS16	SNRPD2	0.816226648	1.34E-42
LGG	Epifactor	RPS16	FBL	0.914965679	3.04E-210
LGG	TF	RPS16	ZNF581	0.801066105	9.02E-120
LGG	TSG	RPS16	GLTSCR2	0.828353576	5.61E-135
LIHC	Cell metabolism gene	RPS16	SNRPD2	0.848052884	3.55E-118
LIHC	Epifactor	RPS16	FBL	0.912579041	1.32E-165
MESO	Cell metabolism gene	RPS16	FAU	0.804666686	6.06E-21
MESO	Epifactor	RPS16	FBL	0.808143475	3.05E-21
MESO	TSG	RPS16	GLTSCR2	0.809069164	2.54E-21
PAAD	Epifactor	RPS16	FBL	0.882014624	4.79E-61
PCPG	Epifactor	RPS16	FBL	0.870740412	6.29E-59
PCPG	TSG	RPS16	GNB2L1	0.855761274	7.73E-55
PCPG	TSG	RPS16	GLTSCR2	0.900157404	1.09E-68
PRAD	Cell metabolism gene	RPS16	PSMB7	0.811488958	5.84E-130
PRAD	Cell metabolism gene	RPS16	POLR2F	0.814954684	6.08E-132
PRAD	Cell metabolism gene	RPS16	POLR2I	0.82011206	5.70E-135
PRAD	Cell metabolism gene	RPS16	TOMM7	0.821014624	1.64E-135
PRAD	Cell metabolism gene	RPS16	NME2	0.827408941	2.00E-139
PRAD	Cell metabolism gene	RPS16	TIMM9	0.834034643	1.17E-143
PRAD	Cell metabolism gene	RPS16	SNRPD2	0.868035511	9.08E-169
PRAD	Cell metabolism gene	RPS16	FAU	0.870090384	1.66E-170
PRAD	CGC	RPS16	NACA	0.846257454	5.63E-152
PRAD	Epifactor	RPS16	FBL	0.880205816	1.63E-179
PRAD	TF	RPS16	ZNF524	0.803801	1.05E-125
PRAD	TF	RPS16	NME2	0.827408941	2.00E-139
PRAD	TSG	RPS16	GLTSCR2	0.802862746	3.37E-125
PRAD	TSG	RPS16	GAS5	0.813637113	3.49E-131
PRAD	TSG	RPS16	GNB2L1	0.856433747	1.78E-159
SKCM	Epifactor	RPS16	FBL	0.82759378	1.89E-120
TGCT	Cell metabolism gene	RPS16	EXOSC5	0.814300857	3.27E-38
TGCT	Cell metabolism gene	RPS16	TBCB	0.815007843	2.51E-38
TGCT	Cell metabolism gene	RPS16	POLR2I	0.863215379	1.43E-47
TGCT	Cell metabolism gene	RPS16	SNRPD2	0.86676167	2.18E-48
TGCT	Epifactor	RPS16	EXOSC5	0.814300857	3.27E-38
TGCT	Epifactor	RPS16	FBL	0.8892874	3.43E-54
THCA	Cell metabolism gene	RPS16	PFDN5	0.800806589	5.26E-129
THCA	Cell metabolism gene	RPS16	SNRPD2	0.839162361	6.87E-153
THCA	Cell metabolism gene	RPS16	FAU	0.839629482	3.22E-153
THCA	TSG	RPS16	GNB2L1	0.820852256	8.97E-141
THYM	Cell metabolism gene	RPS16	POLD4	0.800019049	2.15E-28
THYM	Cell metabolism gene	RPS16	TBCB	0.80166937	1.38E-28
THYM	Cell metabolism gene	RPS16	PSMB6	0.802742949	1.03E-28
THYM	Cell metabolism gene	RPS16	PFDN6	0.803382735	8.65E-29
THYM	Cell metabolism gene	RPS16	PSMA5	0.803561617	8.24E-29
THYM	Cell metabolism gene	RPS16	OAZ1	0.80375845	7.81E-29
THYM	Cell metabolism gene	RPS16	HMBS	0.80625875	3.92E-29
THYM	Cell metabolism gene	RPS16	AAAS	0.807601453	2.70E-29
THYM	Cell metabolism gene	RPS16	WBSCR22	0.811643868	8.58E-30
THYM	Cell metabolism gene	RPS16	EXOSC4	0.815293448	2.98E-30
THYM	Cell metabolism gene	RPS16	SNRPF	0.816558477	2.05E-30
THYM	Cell metabolism gene	RPS16	ZNRD1	0.819162933	9.46E-31
THYM	Cell metabolism gene	RPS16	PSMA4	0.819318615	9.03E-31
THYM	Cell metabolism gene	RPS16	PSME1	0.820242779	6.83E-31
THYM	Cell metabolism gene	RPS16	TIMM17B	0.820996268	5.44E-31
THYM	Cell metabolism gene	RPS16	TOMM40	0.824406129	1.91E-31
THYM	Cell metabolism gene	RPS16	SNRPD1	0.826694189	9.36E-32
THYM	Cell metabolism gene	RPS16	EXOSC5	0.827020067	8.45E-32
THYM	Cell metabolism gene	RPS16	SEC61G	0.827320679	7.68E-32
THYM	Cell metabolism gene	RPS16	DPM3	0.828213006	5.79E-32
THYM	Cell metabolism gene	RPS16	PGP	0.829899511	3.38E-32
THYM	Cell metabolism gene	RPS16	ITPA	0.830052614	3.22E-32
THYM	Cell metabolism gene	RPS16	SRM	0.830569449	2.72E-32
THYM	Cell metabolism gene	RPS16	SMPD2	0.830788665	2.54E-32
THYM	Cell metabolism gene	RPS16	POLA2	0.830833455	2.50E-32
THYM	Cell metabolism gene	RPS16	EXOSC1	0.831418231	2.07E-32
THYM	Cell metabolism gene	RPS16	PSMB1	0.832717259	1.36E-32
THYM	Cell metabolism gene	RPS16	SEC61B	0.833062182	1.21E-32
THYM	Cell metabolism gene	RPS16	POLR2H	0.833221289	1.15E-32
THYM	Cell metabolism gene	RPS16	DTYMK	0.833790445	9.53E-33
THYM	Cell metabolism gene	RPS16	IDH3G	0.835109227	6.16E-33
THYM	Cell metabolism gene	RPS16	LSM3	0.83827492	2.13E-33
THYM	Cell metabolism gene	RPS16	PSMB10	0.838333169	2.09E-33
THYM	Cell metabolism gene	RPS16	DGUOK	0.838512585	1.96E-33
THYM	Cell metabolism gene	RPS16	LSM5	0.839646519	1.33E-33
THYM	Cell metabolism gene	RPS16	DPM2	0.840635835	9.48E-34
THYM	Cell metabolism gene	RPS16	POLD2	0.840962132	8.47E-34
THYM	Cell metabolism gene	RPS16	GALK1	0.841799217	6.34E-34
THYM	Cell metabolism gene	RPS16	MTMR14	0.843239898	3.83E-34
THYM	Cell metabolism gene	RPS16	SNRPB	0.844568799	2.40E-34
THYM	Cell metabolism gene	RPS16	POLR2I	0.845933293	1.47E-34
THYM	Cell metabolism gene	RPS16	PAFAH1B3	0.849009583	4.84E-35
THYM	Cell metabolism gene	RPS16	EBP	0.850600661	2.69E-35
THYM	Cell metabolism gene	RPS16	UROD	0.852849914	1.16E-35
THYM	Cell metabolism gene	RPS16	PHKG2	0.852975924	1.11E-35
THYM	Cell metabolism gene	RPS16	APOA1	0.857319531	2.10E-36
THYM	Cell metabolism gene	RPS16	LSM4	0.862800826	2.37E-37
THYM	Cell metabolism gene	RPS16	MVD	0.863635128	1.69E-37
THYM	Cell metabolism gene	RPS16	TOMM22	0.865776559	6.98E-38
THYM	Cell metabolism gene	RPS16	SNRPD3	0.8665172	5.13E-38
THYM	Cell metabolism gene	RPS16	PFDN5	0.867493141	3.40E-38
THYM	Cell metabolism gene	RPS16	POLR2F	0.868256276	2.46E-38
THYM	Cell metabolism gene	RPS16	TIMM50	0.86881872	1.94E-38
THYM	Cell metabolism gene	RPS16	POLR2J	0.869264922	1.60E-38
THYM	Cell metabolism gene	RPS16	GUK1	0.870293665	1.03E-38
THYM	Cell metabolism gene	RPS16	SSR2	0.873309481	2.76E-39
THYM	Cell metabolism gene	RPS16	FPGS	0.87335364	2.70E-39
THYM	Cell metabolism gene	RPS16	ACOT8	0.876944405	5.38E-40
THYM	Cell metabolism gene	RPS16	PSMB3	0.881167208	7.54E-41
THYM	Cell metabolism gene	RPS16	PSMD13	0.881331794	6.97E-41
THYM	Cell metabolism gene	RPS16	SLC27A5	0.881818467	5.53E-41
THYM	Cell metabolism gene	RPS16	TIMM8B	0.888163598	2.45E-42
THYM	Cell metabolism gene	RPS16	TIMM13	0.890114715	9.05E-43
THYM	Cell metabolism gene	RPS16	PGLS	0.89841171	1.05E-44
THYM	Cell metabolism gene	RPS16	PSMB7	0.8985907	9.50E-45
THYM	Cell metabolism gene	RPS16	PSMC3	0.900819568	2.68E-45
THYM	Cell metabolism gene	RPS16	APRT	0.901943407	1.40E-45
THYM	Cell metabolism gene	RPS16	LSM2	0.902296168	1.14E-45
THYM	Cell metabolism gene	RPS16	FAU	0.934131489	1.59E-55
THYM	Cell metabolism gene	RPS16	SNRPD2	0.939721621	9.16E-58
THYM	CGC	RPS16	MGMT	0.804812493	5.85E-29
THYM	CGC	RPS16	MAP2K2	0.810700965	1.12E-29
THYM	CGC	RPS16	RBM10	0.864203032	1.34E-37
THYM	CGC	RPS16	SDHAF2	0.878138647	3.11E-40
THYM	CGC	RPS16	TFPT	0.907576413	4.77E-47
THYM	Epifactor	RPS16	LAS1L	0.802469555	1.11E-28
THYM	Epifactor	RPS16	HIST1H2AJ	0.809948827	1.39E-29
THYM	Epifactor	RPS16	EXOSC4	0.815293448	2.98E-30
THYM	Epifactor	RPS16	RBX1	0.823868546	2.26E-31
THYM	Epifactor	RPS16	RRP8	0.826351258	1.04E-31
THYM	Epifactor	RPS16	EXOSC5	0.827020067	8.45E-32
THYM	Epifactor	RPS16	EXOSC1	0.831418231	2.07E-32
THYM	Epifactor	RPS16	ZGPAT	0.834805683	6.81E-33
THYM	Epifactor	RPS16	PPM1G	0.836152292	4.35E-33
THYM	Epifactor	RPS16	PRMT7	0.836346161	4.08E-33
THYM	Epifactor	RPS16	DMAP1	0.844352223	2.59E-34
THYM	Epifactor	RPS16	PAF1	0.846621851	1.15E-34
THYM	Epifactor	RPS16	HIST2H2AC	0.847808184	7.49E-35
THYM	Epifactor	RPS16	NOC2L	0.849582225	3.92E-35
THYM	Epifactor	RPS16	MBD3	0.849889796	3.50E-35
THYM	Epifactor	RPS16	TRIM28	0.850203571	3.12E-35
THYM	Epifactor	RPS16	SS18L2	0.855105188	4.94E-36
THYM	Epifactor	RPS16	SIRT6	0.868967615	1.82E-38
THYM	Epifactor	RPS16	INO80E	0.870178658	1.08E-38
THYM	Epifactor	RPS16	C17orf49	0.870863647	8.05E-39
THYM	Epifactor	RPS16	CCDC101	0.87103735	7.47E-39
THYM	Epifactor	RPS16	CXXC1	0.873552732	2.48E-39
THYM	Epifactor	RPS16	PPP4C	0.879908136	1.36E-40
THYM	Epifactor	RPS16	RUVBL2	0.88414495	1.80E-41
THYM	Epifactor	RPS16	ZNHIT1	0.890255027	8.42E-43
THYM	Epifactor	RPS16	PRPF31	0.897102901	2.17E-44
THYM	Epifactor	RPS16	FBL	0.902909217	7.96E-46
THYM	Epifactor	RPS16	TFPT	0.907576413	4.77E-47
THYM	Epifactor	RPS16	BRMS1	0.912546549	2.01E-48
THYM	Epifactor	RPS16	TAF10	0.924806667	3.38E-52
THYM	IUPHAR	RPS16	TOP1MT	0.801808344	1.33E-28
THYM	IUPHAR	RPS16	EGLN2	0.802260524	1.17E-28
THYM	IUPHAR	RPS16	PSMB6	0.802742949	1.03E-28
THYM	IUPHAR	RPS16	MMP24	0.807002495	3.19E-29
THYM	IUPHAR	RPS16	MAP2K2	0.810700965	1.12E-29
THYM	IUPHAR	RPS16	RNPEPL1	0.821118383	5.24E-31
THYM	IUPHAR	RPS16	SMPD2	0.830788665	2.54E-32
THYM	IUPHAR	RPS16	PSMB1	0.832717259	1.36E-32
THYM	IUPHAR	RPS16	PRMT7	0.836346161	4.08E-33
THYM	IUPHAR	RPS16	TWF2	0.846036249	1.42E-34
THYM	IUPHAR	RPS16	TRIM28	0.850203571	3.12E-35
THYM	IUPHAR	RPS16	PHKG2	0.852975924	1.11E-35
THYM	IUPHAR	RPS16	PPIA	0.855899357	3.64E-36
THYM	IUPHAR	RPS16	CSNK2B	0.856062034	3.42E-36
THYM	IUPHAR	RPS16	MVD	0.863635128	1.69E-37
THYM	IUPHAR	RPS16	SIRT6	0.868967615	1.82E-38
THYM	IUPHAR	RPS16	SLC27A5	0.881818467	5.53E-41
THYM	Kinase	RPS16	MAP2K2	0.810700965	1.12E-29
THYM	Kinase	RPS16	TRIM28	0.850203571	3.12E-35
THYM	Kinase	RPS16	PHKG2	0.852975924	1.11E-35
THYM	TF	RPS16	ZNF32	0.807395872	2.86E-29
THYM	TF	RPS16	AKAP8L	0.811943651	7.87E-30
THYM	TF	RPS16	USF1	0.812597482	6.52E-30
THYM	TF	RPS16	ZNF394	0.81382649	4.57E-30
THYM	TF	RPS16	ZNF691	0.815106874	3.15E-30
THYM	TF	RPS16	THAP7	0.815232516	3.03E-30
THYM	TF	RPS16	ZBTB17	0.826918815	8.72E-32
THYM	TF	RPS16	GTF3A	0.831140748	2.26E-32
THYM	TF	RPS16	IRF3	0.833233256	1.14E-32
THYM	TF	RPS16	ZGPAT	0.834805683	6.81E-33
THYM	TF	RPS16	ETV2	0.836679012	3.65E-33
THYM	TF	RPS16	ZNF668	0.83898042	1.67E-33
THYM	TF	RPS16	USF2	0.841423458	7.22E-34
THYM	TF	RPS16	SNAPC2	0.84144393	7.17E-34
THYM	TF	RPS16	ZNF787	0.842752714	4.54E-34
THYM	TF	RPS16	ZNF653	0.843493752	3.50E-34
THYM	TF	RPS16	THAP3	0.843871166	3.07E-34
THYM	TF	RPS16	PIN1	0.847787488	7.55E-35
THYM	TF	RPS16	MBD3	0.849889796	3.50E-35
THYM	TF	RPS16	RBCK1	0.856557193	2.82E-36
THYM	TF	RPS16	ZNF688	0.857783497	1.75E-36
THYM	TF	RPS16	CXXC1	0.873552732	2.48E-39
THYM	TF	RPS16	DRAP1	0.875790237	9.09E-40
THYM	TF	RPS16	ZNF428	0.877126579	4.95E-40
THYM	TF	RPS16	ZNF444	0.885725387	8.30E-42
THYM	TF	RPS16	THYN1	0.900881891	2.58E-45
THYM	TSG	RPS16	AIF1	0.808407426	2.15E-29
THYM	TSG	RPS16	GABARAP	0.811115051	9.98E-30
THYM	TSG	RPS16	MAD1L1	0.820472775	6.38E-31
THYM	TSG	RPS16	PLEKHO1	0.827928039	6.34E-32
THYM	TSG	RPS16	IRF3	0.833233256	1.14E-32
THYM	TSG	RPS16	ZNF668	0.83898042	1.67E-33
THYM	TSG	RPS16	GADD45GIP1	0.840558029	9.74E-34
THYM	TSG	RPS16	PIN1	0.847787488	7.55E-35
THYM	TSG	RPS16	PARK7	0.852482035	1.33E-35
THYM	TSG	RPS16	HTRA2	0.853945497	7.68E-36
THYM	TSG	RPS16	NPRL2	0.866544142	5.07E-38
THYM	TSG	RPS16	SIRT6	0.868967615	1.82E-38
THYM	TSG	RPS16	TSSC4	0.870080158	1.13E-38
THYM	TSG	RPS16	PFN1	0.879025421	2.06E-40
THYM	TSG	RPS16	AIP	0.890071377	9.26E-43
THYM	TSG	RPS16	BRMS1	0.912546549	2.01E-48
THYM	TSG	RPS16	GNB2L1	0.935545532	4.50E-56
THYM	TSG	RPS16	GLTSCR2	0.94657195	8.08E-61
UCEC	Epifactor	RPS16	FBL	0.820879408	2.65E-50
UCS	Cell metabolism gene	RPS16	POLD4	0.800019049	2.15E-28
UCS	Cell metabolism gene	RPS16	TBCB	0.80166937	1.38E-28
UCS	Cell metabolism gene	RPS16	PSMB6	0.802742949	1.03E-28
UCS	Cell metabolism gene	RPS16	PFDN6	0.803382735	8.65E-29
UCS	Cell metabolism gene	RPS16	PSMA5	0.803561617	8.24E-29
UCS	Cell metabolism gene	RPS16	OAZ1	0.80375845	7.81E-29
UCS	Cell metabolism gene	RPS16	HMBS	0.80625875	3.92E-29
UCS	Cell metabolism gene	RPS16	AAAS	0.807601453	2.70E-29
UCS	Cell metabolism gene	RPS16	WBSCR22	0.811643868	8.58E-30
UCS	Cell metabolism gene	RPS16	EXOSC4	0.815293448	2.98E-30
UCS	Cell metabolism gene	RPS16	SNRPF	0.816558477	2.05E-30
UCS	Cell metabolism gene	RPS16	ZNRD1	0.819162933	9.46E-31
UCS	Cell metabolism gene	RPS16	PSMA4	0.819318615	9.03E-31
UCS	Cell metabolism gene	RPS16	PSME1	0.820242779	6.83E-31
UCS	Cell metabolism gene	RPS16	TIMM17B	0.820996268	5.44E-31
UCS	Cell metabolism gene	RPS16	TOMM40	0.824406129	1.91E-31
UCS	Cell metabolism gene	RPS16	SNRPD1	0.826694189	9.36E-32
UCS	Cell metabolism gene	RPS16	EXOSC5	0.827020067	8.45E-32
UCS	Cell metabolism gene	RPS16	SEC61G	0.827320679	7.68E-32
UCS	Cell metabolism gene	RPS16	DPM3	0.828213006	5.79E-32
UCS	Cell metabolism gene	RPS16	PGP	0.829899511	3.38E-32
UCS	Cell metabolism gene	RPS16	ITPA	0.830052614	3.22E-32
UCS	Cell metabolism gene	RPS16	SRM	0.830569449	2.72E-32
UCS	Cell metabolism gene	RPS16	SMPD2	0.830788665	2.54E-32
UCS	Cell metabolism gene	RPS16	POLA2	0.830833455	2.50E-32
UCS	Cell metabolism gene	RPS16	EXOSC1	0.831418231	2.07E-32
UCS	Cell metabolism gene	RPS16	PSMB1	0.832717259	1.36E-32
UCS	Cell metabolism gene	RPS16	SEC61B	0.833062182	1.21E-32
UCS	Cell metabolism gene	RPS16	POLR2H	0.833221289	1.15E-32
UCS	Cell metabolism gene	RPS16	DTYMK	0.833790445	9.53E-33
UCS	Cell metabolism gene	RPS16	IDH3G	0.835109227	6.16E-33
UCS	Cell metabolism gene	RPS16	LSM3	0.83827492	2.13E-33
UCS	Cell metabolism gene	RPS16	PSMB10	0.838333169	2.09E-33
UCS	Cell metabolism gene	RPS16	DGUOK	0.838512585	1.96E-33
UCS	Cell metabolism gene	RPS16	LSM5	0.839646519	1.33E-33
UCS	Cell metabolism gene	RPS16	DPM2	0.840635835	9.48E-34
UCS	Cell metabolism gene	RPS16	POLD2	0.840962132	8.47E-34
UCS	Cell metabolism gene	RPS16	GALK1	0.841799217	6.34E-34
UCS	Cell metabolism gene	RPS16	MTMR14	0.843239898	3.83E-34
UCS	Cell metabolism gene	RPS16	SNRPB	0.844568799	2.40E-34
UCS	Cell metabolism gene	RPS16	POLR2I	0.845933293	1.47E-34
UCS	Cell metabolism gene	RPS16	PAFAH1B3	0.849009583	4.84E-35
UCS	Cell metabolism gene	RPS16	EBP	0.850600661	2.69E-35
UCS	Cell metabolism gene	RPS16	UROD	0.852849914	1.16E-35
UCS	Cell metabolism gene	RPS16	PHKG2	0.852975924	1.11E-35
UCS	Cell metabolism gene	RPS16	APOA1	0.857319531	2.10E-36
UCS	Cell metabolism gene	RPS16	LSM4	0.862800826	2.37E-37
UCS	Cell metabolism gene	RPS16	MVD	0.863635128	1.69E-37
UCS	Cell metabolism gene	RPS16	TOMM22	0.865776559	6.98E-38
UCS	Cell metabolism gene	RPS16	SNRPD3	0.8665172	5.13E-38
UCS	Cell metabolism gene	RPS16	PFDN5	0.867493141	3.40E-38
UCS	Cell metabolism gene	RPS16	POLR2F	0.868256276	2.46E-38
UCS	Cell metabolism gene	RPS16	TIMM50	0.86881872	1.94E-38
UCS	Cell metabolism gene	RPS16	POLR2J	0.869264922	1.60E-38
UCS	Cell metabolism gene	RPS16	GUK1	0.870293665	1.03E-38
UCS	Cell metabolism gene	RPS16	SSR2	0.873309481	2.76E-39
UCS	Cell metabolism gene	RPS16	FPGS	0.87335364	2.70E-39
UCS	Cell metabolism gene	RPS16	ACOT8	0.876944405	5.38E-40
UCS	Cell metabolism gene	RPS16	PSMB3	0.881167208	7.54E-41
UCS	Cell metabolism gene	RPS16	PSMD13	0.881331794	6.97E-41
UCS	Cell metabolism gene	RPS16	SLC27A5	0.881818467	5.53E-41
UCS	Cell metabolism gene	RPS16	TIMM8B	0.888163598	2.45E-42
UCS	Cell metabolism gene	RPS16	TIMM13	0.890114715	9.05E-43
UCS	Cell metabolism gene	RPS16	PGLS	0.89841171	1.05E-44
UCS	Cell metabolism gene	RPS16	PSMB7	0.8985907	9.50E-45
UCS	Cell metabolism gene	RPS16	PSMC3	0.900819568	2.68E-45
UCS	Cell metabolism gene	RPS16	APRT	0.901943407	1.40E-45
UCS	Cell metabolism gene	RPS16	LSM2	0.902296168	1.14E-45
UCS	Cell metabolism gene	RPS16	FAU	0.934131489	1.59E-55
UCS	Cell metabolism gene	RPS16	SNRPD2	0.939721621	9.16E-58
UCS	CGC	RPS16	MGMT	0.804812493	5.85E-29
UCS	CGC	RPS16	MAP2K2	0.810700965	1.12E-29
UCS	CGC	RPS16	RBM10	0.864203032	1.34E-37
UCS	CGC	RPS16	SDHAF2	0.878138647	3.11E-40
UCS	CGC	RPS16	TFPT	0.907576413	4.77E-47
UCS	Epifactor	RPS16	LAS1L	0.802469555	1.11E-28
UCS	Epifactor	RPS16	HIST1H2AJ	0.809948827	1.39E-29
UCS	Epifactor	RPS16	EXOSC4	0.815293448	2.98E-30
UCS	Epifactor	RPS16	RBX1	0.823868546	2.26E-31
UCS	Epifactor	RPS16	RRP8	0.826351258	1.04E-31
UCS	Epifactor	RPS16	EXOSC5	0.827020067	8.45E-32
UCS	Epifactor	RPS16	EXOSC1	0.831418231	2.07E-32
UCS	Epifactor	RPS16	ZGPAT	0.834805683	6.81E-33
UCS	Epifactor	RPS16	PPM1G	0.836152292	4.35E-33
UCS	Epifactor	RPS16	PRMT7	0.836346161	4.08E-33
UCS	Epifactor	RPS16	DMAP1	0.844352223	2.59E-34
UCS	Epifactor	RPS16	PAF1	0.846621851	1.15E-34
UCS	Epifactor	RPS16	HIST2H2AC	0.847808184	7.49E-35
UCS	Epifactor	RPS16	NOC2L	0.849582225	3.92E-35
UCS	Epifactor	RPS16	MBD3	0.849889796	3.50E-35
UCS	Epifactor	RPS16	TRIM28	0.850203571	3.12E-35
UCS	Epifactor	RPS16	SS18L2	0.855105188	4.94E-36
UCS	Epifactor	RPS16	SIRT6	0.868967615	1.82E-38
UCS	Epifactor	RPS16	INO80E	0.870178658	1.08E-38
UCS	Epifactor	RPS16	C17orf49	0.870863647	8.05E-39
UCS	Epifactor	RPS16	CCDC101	0.87103735	7.47E-39
UCS	Epifactor	RPS16	CXXC1	0.873552732	2.48E-39
UCS	Epifactor	RPS16	PPP4C	0.879908136	1.36E-40
UCS	Epifactor	RPS16	RUVBL2	0.88414495	1.80E-41
UCS	Epifactor	RPS16	ZNHIT1	0.890255027	8.42E-43
UCS	Epifactor	RPS16	PRPF31	0.897102901	2.17E-44
UCS	Epifactor	RPS16	FBL	0.902909217	7.96E-46
UCS	Epifactor	RPS16	TFPT	0.907576413	4.77E-47
UCS	Epifactor	RPS16	BRMS1	0.912546549	2.01E-48
UCS	Epifactor	RPS16	TAF10	0.924806667	3.38E-52
UCS	IUPHAR	RPS16	TOP1MT	0.801808344	1.33E-28
UCS	IUPHAR	RPS16	EGLN2	0.802260524	1.17E-28
UCS	IUPHAR	RPS16	PSMB6	0.802742949	1.03E-28
UCS	IUPHAR	RPS16	MMP24	0.807002495	3.19E-29
UCS	IUPHAR	RPS16	MAP2K2	0.810700965	1.12E-29
UCS	IUPHAR	RPS16	RNPEPL1	0.821118383	5.24E-31
UCS	IUPHAR	RPS16	SMPD2	0.830788665	2.54E-32
UCS	IUPHAR	RPS16	PSMB1	0.832717259	1.36E-32
UCS	IUPHAR	RPS16	PRMT7	0.836346161	4.08E-33
UCS	IUPHAR	RPS16	TWF2	0.846036249	1.42E-34
UCS	IUPHAR	RPS16	TRIM28	0.850203571	3.12E-35
UCS	IUPHAR	RPS16	PHKG2	0.852975924	1.11E-35
UCS	IUPHAR	RPS16	PPIA	0.855899357	3.64E-36
UCS	IUPHAR	RPS16	CSNK2B	0.856062034	3.42E-36
UCS	IUPHAR	RPS16	MVD	0.863635128	1.69E-37
UCS	IUPHAR	RPS16	SIRT6	0.868967615	1.82E-38
UCS	IUPHAR	RPS16	SLC27A5	0.881818467	5.53E-41
UCS	Kinase	RPS16	MAP2K2	0.810700965	1.12E-29
UCS	Kinase	RPS16	TRIM28	0.850203571	3.12E-35
UCS	Kinase	RPS16	PHKG2	0.852975924	1.11E-35
UCS	TF	RPS16	ZNF32	0.807395872	2.86E-29
UCS	TF	RPS16	AKAP8L	0.811943651	7.87E-30
UCS	TF	RPS16	USF1	0.812597482	6.52E-30
UCS	TF	RPS16	ZNF394	0.81382649	4.57E-30
UCS	TF	RPS16	ZNF691	0.815106874	3.15E-30
UCS	TF	RPS16	THAP7	0.815232516	3.03E-30
UCS	TF	RPS16	ZBTB17	0.826918815	8.72E-32
UCS	TF	RPS16	GTF3A	0.831140748	2.26E-32
UCS	TF	RPS16	IRF3	0.833233256	1.14E-32
UCS	TF	RPS16	ZGPAT	0.834805683	6.81E-33
UCS	TF	RPS16	ETV2	0.836679012	3.65E-33
UCS	TF	RPS16	ZNF668	0.83898042	1.67E-33
UCS	TF	RPS16	USF2	0.841423458	7.22E-34
UCS	TF	RPS16	SNAPC2	0.84144393	7.17E-34
UCS	TF	RPS16	ZNF787	0.842752714	4.54E-34
UCS	TF	RPS16	ZNF653	0.843493752	3.50E-34
UCS	TF	RPS16	THAP3	0.843871166	3.07E-34
UCS	TF	RPS16	PIN1	0.847787488	7.55E-35
UCS	TF	RPS16	MBD3	0.849889796	3.50E-35
UCS	TF	RPS16	RBCK1	0.856557193	2.82E-36
UCS	TF	RPS16	ZNF688	0.857783497	1.75E-36
UCS	TF	RPS16	CXXC1	0.873552732	2.48E-39
UCS	TF	RPS16	DRAP1	0.875790237	9.09E-40
UCS	TF	RPS16	ZNF428	0.877126579	4.95E-40
UCS	TF	RPS16	ZNF444	0.885725387	8.30E-42
UCS	TF	RPS16	THYN1	0.900881891	2.58E-45
UCS	TSG	RPS16	AIF1	0.808407426	2.15E-29
UCS	TSG	RPS16	GABARAP	0.811115051	9.98E-30
UCS	TSG	RPS16	MAD1L1	0.820472775	6.38E-31
UCS	TSG	RPS16	PLEKHO1	0.827928039	6.34E-32
UCS	TSG	RPS16	IRF3	0.833233256	1.14E-32
UCS	TSG	RPS16	ZNF668	0.83898042	1.67E-33
UCS	TSG	RPS16	GADD45GIP1	0.840558029	9.74E-34
UCS	TSG	RPS16	PIN1	0.847787488	7.55E-35
UCS	TSG	RPS16	PARK7	0.852482035	1.33E-35
UCS	TSG	RPS16	HTRA2	0.853945497	7.68E-36
UCS	TSG	RPS16	NPRL2	0.866544142	5.07E-38
UCS	TSG	RPS16	SIRT6	0.868967615	1.82E-38
UCS	TSG	RPS16	TSSC4	0.870080158	1.13E-38
UCS	TSG	RPS16	PFN1	0.879025421	2.06E-40
UCS	TSG	RPS16	AIP	0.890071377	9.26E-43
UCS	TSG	RPS16	BRMS1	0.912546549	2.01E-48
UCS	TSG	RPS16	GNB2L1	0.935545532	4.50E-56
UCS	TSG	RPS16	GLTSCR2	0.94657195	8.08E-61
UVM	Cell metabolism gene	RPS16	SSR2	0.861343274	1.19E-24
UVM	Cell metabolism gene	RPS16	FAU	0.881854121	3.47E-27
UVM	Epifactor	RPS16	FBL	0.904825358	1.18E-30
UVM	TF	RPS16	ZNF581	0.834701033	6.64E-22
UVM	TSG	RPS16	GNB2L1	0.897149318	2.10E-29
UVM	TSG	RPS16	GLTSCR2	0.902700303	2.69E-30

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS16	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS16	RPS27A	1.75396693785956	0.000187873840332031
STAD	RPS16	RPS23	1.85076760664576	0.000364991836249828
COAD	RPS16	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS16	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS16	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS16	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS16	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS16	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS16	RPL19	-1.31398026615725	0.00993159558412698
LUSC	RPS16	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS16	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS16	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS16	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS16	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS16	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPS16	RPS23	-2.03658159814007	0.046875
KIRC	RPS16	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS16	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS16	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS16	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS16	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS16	RPL8	-1.53003692350119	6.0301274061203e-05
BRCA	RPS16	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS16	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS16	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS16	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS16	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS16

MAGEB2, DDX56, CNBP, PINX1, CDC5L, TERF1, NOP56, EBNA-LP, RAD21, NDRG1, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RPS4X, APP, RPL12, RPL13, RPS25, RPL10A, RPL11, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL23, RPL24, RPL27A, RPL27, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPLP1, RPS12, RPS13, RPS19, RPS23, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS5, RPS6, RPS8, RPSA, RPS11, RPS17, RPS15A, RPL10, RPS24, RPLP2, RPS20, RPL22, RPLP0, RPS10, RPS15, RPS9, RPS7, RPL30, RPS14, RPL36, RPS21, RPS27A, FAU, RPL17, RPL29, RPL32, EEF2, EEF1A1, RPS29, ILF2, ILF3, HNRNPM, NCL, HNRNPU, TUFM, ACTA2, HSP90AB1, RPL10L, RPLP0P6, RPS27L, PPT2, PRKCDBP, ATP5I, CDH2, HSP90AA1, MLEC, TXN2, UQCRB, DDX5, HSPA5, HSP90AA5P, RPS10P5, RBM8A, ESR1, SMURF1, FN1, VCAM1, UBL4A, ITGA4, US3, PAN2, CD81, IGSF8, ICAM1, LARP7, TARDBP, PARK2, LARP1, DYNLT3, EIF2A, EIF3L, GNB2L1, RPS18, WIBG, RPS27, SND1, TSR1, ASB14, ASB15, ZBTB1, AURKA, AURKB, CDKN1A, CEP250, CEP57, CEP76, TUBG1, TUBGCP4, TP53, HUWE1, EED, ATP6V0D1, RPL13A, RPL28, RPL34, RPL35, RPL35A, RPL38, RPL3L, PABPC1, RPL26, RPL26L1, LOC101929876, VAPA, SFN, gag, XPO1, AHSA1, NPM1, CKAP5, CENPQ, EXOSC5, EXOSC1, Eif3a, Eif3e, Ktn1, Eif3i, Rpl35, Srp72, Rrbp1, SKI, MCM2, Ksr1, ESRRB, RC3H1, WDR4, ZNF746, RRS1, HIST1H1E, H2AFX, RPF1, FGF8, BHLHA15, E4F1, CYLD, INO80B, TRIM25, HEY1, BRCA1, MTF1, ZNF598, FBXO7, HSPA8, DIMT1, ADSS, API5, CTNNB1, HDAC4, IGF1R, PCBP1, TRIP4, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, RNF31, SPDL1, RIOK1, HEXIM1, MEPCE, RNF123, SNAI1, AGR2, RECQL4, DCPS, REST, ZFP36L2, MYC, CDK9, Prkaa1, KRT17, METTL14, KIAA1429, EIF4B, DCAF13, RC3H2, PHB, NR2C2, HDAC2, CTCF, ATXN3, VRK1, SNRNP70, ITFG1, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, SOX2, TRIM28, SQSTM1, CMTR1, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, PVT1, HCVgp1, ORF50, ZC3H18, FAM177B, C1orf87, RBM25, M, nsp4, nsp6, ORF3a, ORF7a, ORF7b, ORF8, NEK4, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, INS, BRD4, NINL, RBM45, CIC, Apc2, RBM39, FBP1, LGALS9, RIN3, DDX58, SPOP, AR, UFL1, DDRGK1, TRIM37, ATG10, FZR1, WDR5, PAGE4, NUDCD2, NAA40, PURG, PARN, DKC1, TBC1D17, HP1BP3, FGF17, SUZ12, U2SURP, DHX36, ZNF724P, SRBD1, ZC3H8, PIP5K1A, RSL1D1, PRKRIR, DHX57, LTV1, YBX1, NOB1, CMSS1, RBM19, GPATCH11, YTHDF1, BBX, PRDM10, THAP11, ZCCHC9, H2AFB2, ZNF629, ZFR, RSBN1L, ZBTB24, TFB1M, H2AFB3, SURF6, LLPH, DDX55, HIST1H1B, EIF2AK2, CHERP, ZNF574, ZNF689, CCDC140, LIN28B, KRR1, NOG, PATZ1, RPSAP58, ZCCHC6, DDX21, TOE1, RPL36AL, NOP14, NOC4L, FGF13, BMS1, BLM, ZNF92, HIST1H1D, GLI4, ZNF668, RRP12, PRDM15, ZKSCAN8, NEIL1, SRSF4, PRR3, HELZ2, XRN1, RIOK2, YTHDC2, TSPYL2, ZNF346, FARS2, TRMT1L, GNL2, TRIM71, PDCD11, YBX2, SRSF6, SRSF5, DAXX, BYSL, STRBP, SRFBP1, SF3B2, HIST1H2AE, RPS4Y2, KNOP1, DDX27, ZBTB11, NOL12, MPHOSPH10, TBC1D15, YBX3, DDX10, UTP3, APOBEC3F, ZNF22, CCDC137, DDX50, HIST1H1A, ABT1, NOP9, NSA2, FAM207A, ZCRB1, KRI1, HIST1H2AM, SPRTN, BTF3, FBXW7, E, nsp1, nsp16, nsp5, S, nsp10, RCHY1, TAX1BP1, MAP1LC3B, USP1, PSMD9, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS16	chr19	39923985	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS16	BRCA	chr19	39924348	39924348	G	T	Silent	p.I68	3
RPS16	BRCA	chr19	39926258	39926258	G	C	Missense_Mutation	p.L47V	3
RPS16	CESC	chr19	39926509	39926509	A	C	Silent		2
RPS16	CESC	chr19	39926521	39926521	G	A	Silent		2
RPS16	TGCT	chr19	39923952	39923952	G	A	Silent		2
RPS16	COAD	chr19	39923952	39923952	G	A	Silent	p.G134G	2
RPS16	UCEC	chr19	39924389	39924389	C	T	Missense_Mutation	p.V55I	2
RPS16	SKCM	chr19	39924333	39924333	C	T	Silent	p.K73K	2
RPS16	BLCA	chr19	39926340	39926340	C	T	Silent	p.A19A	2
RPS16	LUAD	chr19	39924008	39924008	C	A	Missense_Mutation	p.M147I	2
RPS16	LUAD	chr19	39924275	39924275	T	C	Missense_Mutation	p.R93G	2
RPS16	LUAD	chr19	39924009	39924009	A	T	Nonsense_Mutation	p.Y115*	1
RPS16	BLCA	chr19	39924298	39924298	G	A	Missense_Mutation		1
RPS16	STAD	chr19	39923918	39923918	G	A	Missense_Mutation		1
RPS16	LUAD	chr19	39924010	39924010	T	A	Missense_Mutation	p.M147L	1
RPS16	BLCA	chr19	39926329	39926329	G	A	Missense_Mutation		1
RPS16	LUAD	chr19	39924008	39924010	CAT	ATA	Missense_Mutation	p.115_116YD>LY	1
RPS16	BLCA	chr19	39924220	39924220	G	T	Missense_Mutation	p.S111Y	1
RPS16	THYM	chr19	39926492	39926492	C	T	Missense_Mutation	p.R15H	1
RPS16	COAD	chr19	39926521	39926521	G	A	Silent	p.G5G	1
RPS16	READ	chr19	39924346	39924346	C	A	Missense_Mutation	p.R69L	1
RPS16	BLCA	chr19	39924391	39924391	G	A	Missense_Mutation	p.P54L	1
RPS16	KIRC	chr19	39926341	39926341	G	T	Missense_Mutation	p.A19E	1
RPS16	BLCA	chr19	39924227	39924227	A	T	Missense_Mutation	p.C109S	1
RPS16	KIRP	chr19	39923961	39923961	C	G	Missense_Mutation	p.K131N	1
RPS16	BLCA	chr19	39924220	39924220	G	T	Missense_Mutation		1
RPS16	SKCM	chr19	39924197	39924197	G	A	Missense_Mutation	p.S87F	1
RPS16	KIRP	chr19	39926291	39926291	C	A	Missense_Mutation		1
RPS16	BLCA	chr19	39924227	39924227	A	T	Missense_Mutation		1
RPS16	SKCM	chr19	39924009	39924009	A	G	Silent	p.Y115Y	1
RPS16	BLCA	chr19	39924298	39924298	G	A	Missense_Mutation	p.S85F	1
RPS16	LIHC	chr19	39926515	39926515	C	A	Silent	p.L7L	1
RPS16	BLCA	chr19	39924342	39924342	G	A	Silent		1
RPS16	SKCM	chr19	39924197	39924197	G	A	Missense_Mutation	p.P119S	1
RPS16	LIHC	chr19	39924027	39924027	T	-	Frame_Shift_Del	p.K141fs	1
RPS16	BLCA	chr19	39924348	39924348	G	A	Silent		1
RPS16	SKCM	chr19	39924009	39924009	A	G	Missense_Mutation	p.M147T	1
RPS16	BLCA	chr19	39924391	39924391	G	A	Missense_Mutation		1
RPS16	STAD	chr19	39923918	39923918	G	A	Nonsense_Mutation	p.R146X	1
RPS16	CESC	chr19	39923928	39923928	C	T	Silent		1
RPS16	BLCA	chr19	39926340	39926340	C	T	Silent		1
RPS16	STAD	chr19	39923918	39923918	G	A	Nonsense_Mutation	p.R146*	1

Copy number variation (CNV) of RPS16
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS16
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103097	N/A	BE732178	ACTB	chr7	5568957	-	RPS16	chr19	39926573	-
103097	LUAD	TCGA-44-2662-01A	ACTN4	chr19	39138546	+	RPS16	chr19	39924400	-
103097	LUAD	TCGA-44-2662-01A	ACTN4	chr19	39138547	+	RPS16	chr19	39924401	-
103097	LUAD	TCGA-44-2662-01A	ACTN4	chr19	39138547	+	RPS16	chr19	39926348	-
103097	N/A	EC568246	COL28A1	chr7	7398912	-	RPS16	chr19	39923854	+
103097	N/A	CB049511	CTNNA3	chr10	69120173	-	RPS16	chr19	39923864	+
103097	N/A	CB049229	FSIP1	chr15	40002642	-	RPS16	chr19	39923864	+
103097	N/A	AA484132	KIF1B	chr1	10310419	+	RPS16	chr19	39923850	+
103097	N/A	BG998400	LRRC38	chr1	13802168	+	RPS16	chr19	39926191	+
103097	PRAD	TCGA-M7-A720-01A	NRBP1	chr2	27660227	+	RPS16	chr19	39924401	-
103097	STAD	TCGA-CD-A4MI	RALGAPA2	chr20	20505049	-	RPS16	chr19	39924401	-
89617	N/A	AA533314	RPS16	chr19	39923864	-	BIK	chr22	43513381	-
101296	N/A	AA535560	RPS16	chr19	39923851	-	C10orf11	chr10	77466529	-
88856	N/A	AA523142	RPS16	chr19	39923850	-	C22orf34	chr22	49865547	+
96297	N/A	BU620241	RPS16	chr19	39924320	+	CCND1	chr11	69468566	-
77468	N/A	BG575496	RPS16	chr19	39923850	-	CTC-347C20.1	chr5	72057351	+
100995	N/A	BU571079	RPS16	chr19	39923846	-	DLG2	chr11	83735877	-
88899	N/A	BI858915	RPS16	chr19	39923850	-	DYNAP	chr18	52244829	+
101649	OV	TCGA-25-2404	RPS16	chr19	39926246	-	EIF3K	chr19	39123069	+
77468	N/A	BE904292	RPS16	chr19	39926575	+	FBL	chr19	40337034	-
77468	N/A	AI114445	RPS16	chr19	39926560	+	FGA	chr4	155507364	-
90617	N/A	CB049230	RPS16	chr19	39923864	-	FSIP1	chr15	40002642	+
81374	N/A	CB528938	RPS16	chr19	39924014	+	GABARAPL1	chr12	10374746	-
103040	N/A	BP430119	RPS16	chr19	39924313	-	GAPDH	chr12	6647295	+
94402	N/A	AI541256	RPS16	chr19	39923854	-	GOLPH3	chr5	32133010	-
95904	N/A	BE621901	RPS16	chr19	39924390	+	MCM5	chr22	35808549	-
77468	N/A	BF341473	RPS16	chr19	39923854	-	MSR1	chr8	15978119	+
98518	N/A	DT219761	RPS16	chr19	39923847	-	NLGN1	chr3	173430589	-
86596	N/A	BE906373	RPS16	chr19	39926573	+	NOL7	chr6	13615623	+
77468	N/A	BP226597	RPS16	chr19	39923864	-	RND1	chr12	49253880	-
77468	N/A	CB049512	RPS16	chr19	39923864	-	SEC24B-AS1	chr4	110321683	+
102780	N/A	BE843019	RPS16	chr19	39923922	-	UBD	chr6	29527498	-
77468	N/A	AA508438	RPS16	chr19	39923853	-	ZNF90	chr19	20236053	+
77468	N/A	AA643824	RPS16	chr19	39923864	-	ZNF90	chr19	20236051	+
77468	N/A	AA730671	RPS16	chr19	39923906	-	ZNF90	chr19	20236162	-
77468	N/A	BF244803	RPS16	chr19	39923851	-	ZNF90	chr19	20236084	+
103097	N/A	AA532948	SEC24B-AS1	chr4	110321683	-	RPS16	chr19	39923864	+
103097	OV	TCGA-24-2038	SSC5D	chr19	56002447	+	RPS16	chr19	39924401	-
103097	LUSC	TCGA-NC-A5HN	SUPT5H	chr19	39936277	+	RPS16	chr19	39924401	-
103097	N/A	AW609804	UBD	chr6	29527498	+	RPS16	chr19	39923922	+
103097	N/A	BC070487	ZFAS1	chr20	47895191	-	RPS16	chr19	39926556	-
103097	N/A	BG152663	ZNF90	chr19	20236361	-	RPS16	chr19	39923850	+
103097	N/A	EC509044	ZNF90	chr19	20236271	-	RPS16	chr19	39923866	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS16	0.000579506800259142	0.016
SARC	RPS16	0.0165408854833088	0.45
LUSC	RPS16	0.0264541548003376	0.69
TGCT	RPS16	0.0269407161785162	0.69
ACC	RPS16	0.0291376395291083	0.7

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	RPS16	0.0264956857451502	0.85
BRCA	RPS16	0.000557721662917881	0.018
THYM	RPS16	0.0448311503415522	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source