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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL9 (NCBI Gene ID:65005)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL9
	Gene ID: 65005
	Gene Symbol	MRPL9
	Gene ID	65005
	Gene Name	mitochondrial ribosomal protein L9
	Synonyms	L9mt
	Cytomap	1q21.3
	Type of Gene	protein-coding
	Description	39S ribosomal protein L9, mitochondrialmitochondrial large ribosomal subunit protein bL9m
	Modification date	20200313
	UniProtAcc	Q9BYD2

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL9	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL9[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL9	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000368830	151733291	151733375	In-frame
ENST00000368830	151733926	151734028	In-frame
ENST00000368830	151734580	151734631	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000368830	151733291	151733375	1313	674	757	267	196	224
ENST00000368830	151733926	151734028	1313	572	673	267	162	196
ENST00000368830	151734580	151734631	1313	521	571	267	145	162

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9BYD2	145	162	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
Q9BYD2	196	224	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
Q9BYD2	162	196	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
Q9BYD2	196	224	210	210	Natural variant	ID=VAR_028137;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11279069;Dbxref=dbSNP:rs8480,PMID:11279069

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	MRPL9	1.16888038960038	0.000120222568511963
STAD	MRPL9	-1.54523483458273	0.0118026207201183

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	MRPL9	0.150393224	0.009322867
HNSC	MRPL9	0.088307859	0.03172172
PRAD	MRPL9	0.10739752	0.049178809

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL9 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	MRPL9	PSMD4	0.816882162	4.38E-20
ACC	Epifactor	MRPL9	VPS72	0.837283527	6.97E-22
BLCA	Cell metabolism gene	MRPL9	PSMB4	0.81147398	5.75E-101
BRCA	Cell metabolism gene	MRPL9	PSMB4	0.824702737	2.90E-303
BRCA	Epifactor	MRPL9	VPS72	0.869249257	0
CHOL	Cell metabolism gene	MRPL9	POLR3C	0.800275282	4.20E-11
CHOL	Cell metabolism gene	MRPL9	PPOX	0.810780924	1.47E-11
CHOL	Cell metabolism gene	MRPL9	FLAD1	0.815041593	9.44E-12
CHOL	Cell metabolism gene	MRPL9	PI4KB	0.818168854	6.76E-12
CHOL	Cell metabolism gene	MRPL9	PSMD4	0.82001047	5.54E-12
CHOL	Cell metabolism gene	MRPL9	SSR2	0.864674936	1.93E-14
CHOL	Cell metabolism gene	MRPL9	SNRPE	0.868785569	1.04E-14
CHOL	Cell metabolism gene	MRPL9	B4GALT3	0.893049588	1.64E-16
CHOL	CGC	MRPL9	SETDB1	0.8545304	8.21E-14
CHOL	CGC	MRPL9	PRCC	0.895455784	1.03E-16
CHOL	Epifactor	MRPL9	SETDB1	0.8545304	8.21E-14
CHOL	Epifactor	MRPL9	USP21	0.882970451	1.03E-15
CHOL	Epifactor	MRPL9	VPS72	0.932295888	1.32E-20
CHOL	IUPHAR	MRPL9	PI4KB	0.818168854	6.76E-12
CHOL	IUPHAR	MRPL9	CLK2	0.851979455	1.16E-13
CHOL	IUPHAR	MRPL9	SETDB1	0.8545304	8.21E-14
CHOL	Kinase	MRPL9	CLK2	0.851979455	1.16E-13
CHOL	TF	MRPL9	ZNF692	0.829850374	1.84E-12
CHOL	TF	MRPL9	USF1	0.830410612	1.72E-12
CHOL	TF	MRPL9	SETDB1	0.8545304	8.21E-14
CHOL	TSG	MRPL9	GAS5	0.832126538	1.41E-12
COAD	Cell metabolism gene	MRPL9	CCT3	0.814919586	1.86E-79
COAD	Cell metabolism gene	MRPL9	SNRPE	0.848264896	2.75E-92
COAD	Epifactor	MRPL9	VPS72	0.848705584	1.77E-92
DLBC	Cell metabolism gene	MRPL9	SNRPE	0.805524595	5.05E-12
DLBC	CGC	MRPL9	PRCC	0.850990229	1.86E-14
DLBC	Epifactor	MRPL9	VPS72	0.832178058	2.31E-13
KICH	Cell metabolism gene	MRPL9	TBCE	0.802448267	1.16E-21
KICH	Cell metabolism gene	MRPL9	PPOX	0.804570367	7.51E-22
KICH	Cell metabolism gene	MRPL9	LSM2	0.81119494	1.89E-22
KICH	Cell metabolism gene	MRPL9	EXOSC1	0.818665198	3.73E-23
KICH	Cell metabolism gene	MRPL9	NUDT5	0.837777717	4.09E-25
KICH	Cell metabolism gene	MRPL9	PSMD4	0.895192675	5.44E-33
KICH	Epifactor	MRPL9	DPY30	0.817498917	4.83E-23
KICH	Epifactor	MRPL9	EXOSC1	0.818665198	3.73E-23
KIRP	Cell metabolism gene	MRPL9	SNRPE	0.839913108	3.33E-87
LIHC	Epifactor	MRPL9	VPS72	0.856785749	3.68E-123
LUAD	Cell metabolism gene	MRPL9	FLAD1	0.819935229	3.57E-141
LUAD	Cell metabolism gene	MRPL9	PSMD4	0.845804782	9.26E-159
LUAD	Cell metabolism gene	MRPL9	PSMB4	0.846870151	1.49E-159
LUAD	Epifactor	MRPL9	VPS72	0.856198949	9.17E-167
LUSC	Cell metabolism gene	MRPL9	PSMD4	0.854681436	5.33E-159
LUSC	Cell metabolism gene	MRPL9	PSMB4	0.861390846	3.16E-164
LUSC	Epifactor	MRPL9	VPS72	0.846336637	7.45E-153
OV	Epifactor	MRPL9	VPS72	0.834550711	3.25E-81
PAAD	Cell metabolism gene	MRPL9	CCT3	0.804294131	8.95E-43
PAAD	Cell metabolism gene	MRPL9	PFDN2	0.810743034	5.91E-44
PAAD	Cell metabolism gene	MRPL9	PSMB4	0.817074947	3.70E-45
PAAD	Cell metabolism gene	MRPL9	FLAD1	0.841658069	2.58E-50
PAAD	Cell metabolism gene	MRPL9	PSMD4	0.884335123	8.85E-62
PAAD	Epifactor	MRPL9	VPS72	0.85271814	6.24E-53
PCPG	Epifactor	MRPL9	VPS72	0.849888048	2.33E-53
PRAD	Cell metabolism gene	MRPL9	PSMB4	0.801921046	1.08E-124
READ	Cell metabolism gene	MRPL9	FLAD1	0.800626274	1.19E-24
READ	Cell metabolism gene	MRPL9	PSMB4	0.801013059	1.09E-24
READ	Epifactor	MRPL9	VPS72	0.804980022	4.30E-25
STAD	Cell metabolism gene	MRPL9	PSMB4	0.806300097	3.21E-104
STAD	Epifactor	MRPL9	VPS72	0.830670998	5.21E-116
TGCT	Cell metabolism gene	MRPL9	MTX1	0.801625531	3.12E-36
TGCT	Cell metabolism gene	MRPL9	PSMD4	0.887331213	1.22E-53
TGCT	Cell metabolism gene	MRPL9	PSMB4	0.897337094	1.41E-56
THYM	Cell metabolism gene	MRPL9	PSMD4	0.814086085	4.24E-30
THYM	Cell metabolism gene	MRPL9	PSMB4	0.830691414	2.62E-32
THYM	Cell metabolism gene	MRPL9	SNRPE	0.835884877	4.76E-33
THYM	Epifactor	MRPL9	VPS72	0.806237068	3.94E-29
UCEC	Epifactor	MRPL9	VPS72	0.81310512	1.20E-48
UCS	Cell metabolism gene	MRPL9	PSMD4	0.814086085	4.24E-30
UCS	Cell metabolism gene	MRPL9	PSMB4	0.830691414	2.62E-32
UCS	Cell metabolism gene	MRPL9	SNRPE	0.835884877	4.76E-33
UCS	Epifactor	MRPL9	VPS72	0.806237068	3.94E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPL9	MRPL32	-3.7979134181794	0.000134327661287861
STAD	MRPL9	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL9	MRPL11	-1.04966837625557	0.000354478033746394
KIRC	MRPL9	MRPL24	-1.34802117098363	0.000369980864421695
LIHC	MRPL9	MRPL13	1.54402472107614	0.000655351190157038
LUAD	MRPL9	MRPL32	-2.1966239418264	0.00121089428940613
KIRP	MRPL9	MRPL19	-1.9689242575519	0.00179363833740354
BLCA	MRPL9	MRPL27	-4.19270554058168	0.00202178955078125
KICH	MRPL9	MRPL24	1.42000841970622	0.00378090143203735
CHOL	MRPL9	MRPL3	-2.68429255990621	0.00390625
ESCA	MRPL9	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL9	MRPL15	1.17181689924568	0.00513318181037904
KICH	MRPL9	MRPL19	-2.18550705564541	0.00672554969787598
ESCA	MRPL9	MRPL13	-1.07746088474995	0.0068359375
ESCA	MRPL9	MRPL17	-1.18756178214998	0.009765625
LIHC	MRPL9	MRPL17	-1.06225729770915	0.0124123499319886
KIRP	MRPL9	MRPL24	-2.9092481117556	0.0139979305677116
STAD	MRPL9	MRPL4	1.4393539135682	0.0279771662317216
KIRC	MRPL9	MRPL32	-2.79664327578899	0.0376051795400881
CHOL	MRPL9	MRPL19	-2.09295650388558	0.0390625
LUAD	MRPL9	MRPL24	-3.53731160751159	1.10656371043093e-09
PRAD	MRPL9	MRPL11	1.12581653394628	1.15996224044503e-05
BRCA	MRPL9	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL9	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL9	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL9	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL9	MRPL3	1.69955762234244	1.97132191719422e-08
LIHC	MRPL9	MRPL32	-1.20074144698753	2.24402029682138e-06
LIHC	MRPL9	MRPL24	1.01230339617377	2.71217975233539e-06
COAD	MRPL9	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL9	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL9	MRPL27	-1.81809468729316	3.90393047420304e-06
BRCA	MRPL9	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL9	MRPL17	-6.83409683292749	6.93230040561614e-07
LUSC	MRPL9	MRPL24	-2.80841690659614	7.95689711347621e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL9

ICT1, CAND1, MRPL15, MRPL37, MRPL3, MRPL44, MRPL39, MRPL38, MRPL19, MRPL2, MRPL45, MRPL40, MRPL55, MRPL11, MRPL13, MRPL32, MRPL23, MRPL12, MRPL28, TMEM177, ILF3, DDX28, SLC25A3, PLP2, EIF4H, SAT1, SOX2, FAM9B, EGFR, RPL13, ZNF22, RBMS3, RPL6, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPS30, MRPL47, GAA, MRPL17, MRPL18, MRPL46, MRPL48, DLD, GANAB, MRPL24, NSF, SCFD1, PLBD2, MRPL49, SLC25A10, EIF4G1, JUP, TK2, MRPL33, MRPL42, MRPL22, ITSN2, MRPL51, MRPL30, MRPL27, MRPL35, MRPL50, MRPL16, MRPL20, MRPS18A, NLN, MRPL14, MRPL41, MRPL34, MRPL1, THAP9, MRPL43, MICALL1, GADD45GIP1, MRPL53, MRPL54, MRPL52, MRPL10, TMEM92, MRPL21, NANOG, POU5F1, C6orf203, MEPCE, LARP7, UBE3A, RECQL4, SERBP1, MRM1, HSPD1, TRMT61B, AURKAIP1, ALYREF, SNRNP70, TRIM28, CDC37, HNRNPK, PLEKHA4, ESR1, ZC3HAV1, ACAD9, AUH, C12orf65, C1QBP, C21orf33, CHCHD1, CS, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD3, RPUSD4, SLIRP, SSBP1, TACO1, TBRG4, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, Apc2, DNAJC15, HSCB, DCAF13, CIAO1, FAM76B, EZH2, HTRA4, RPL35, RPL13A, H2AFB3, RPL37, RPL19, RBMS2, SRSF3, HIST1H1E, LIN28A, RPL26, RPL18, KRR1, ABT1, MALSU1, APOBEC3C, GNL3, GLI4, RPL27A, THAP3, HNRNPU, RPL17, YBX2, MRPS17, FAU, IGF2BP3, H1FNT, SRSF4, MSI1, YBX1, PRR3, ZNF485, SRSF5, RPL10, MRPS25, HIST1H1T, APOBEC3D, RPS6, NEIL1, HIST1H1A, FAHD1, RPL23A, HIST1H2AM, SRSF7,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPL9	chr1	151733379	C	CAA	Duplication	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL9	chr1	151734985	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL9	CESC	chr1	151735576	151735576	T	C	Missense_Mutation		3
MRPL9	SKCM	chr1	151734888	151734888	G	A	Silent	p.S133S	3
MRPL9	UCEC	chr1	151734931	151734931	C	T	Missense_Mutation	p.G119D	3
MRPL9	HNSC	chr1	151735515	151735515	C	T	Silent	p.K87K	2
MRPL9	SKCM	chr1	151733936	151733936	G	A	Silent	p.F193F	2
MRPL9	HNSC	chr1	151732598	151732598	C	A	Missense_Mutation	p.K244N	2
MRPL9	UCEC	chr1	151732590	151732590	C	A	Missense_Mutation	p.R247I	2
MRPL9	BRCA	chr1	151734858	151734858	C	A	Missense_Mutation	p.E143D	2
MRPL9	SKCM	chr1	151734008	151734008	G	A	Silent	p.S169S	2
MRPL9	HNSC	chr1	151732587	151732587	T	C	Missense_Mutation	p.Y248C	2
MRPL9	UCEC	chr1	151733313	151733313	G	A	Silent	p.G217	2
MRPL9	BRCA	chr1	151735549	151735549	C	T	Missense_Mutation	p.R76Q	2
MRPL9	SKCM	chr1	151733957	151733957	A	T	Silent	p.P186P	2
MRPL9	UCEC	chr1	151734876	151734876	C	A	Missense_Mutation	p.K137N	2
MRPL9	SKCM	chr1	151733958	151733958	G	A	Missense_Mutation	p.P186L	2
MRPL9	KIRP	chr1	151735832	151735832	C	T	Missense_Mutation	p.A42T	2
MRPL9	STAD	chr1	151733319	151733319	C	T	Silent	p.R215R	2
MRPL9	STAD	chr1	151732634	151732634	T	A	Missense_Mutation	p.R232S	2
MRPL9	HNSC	chr1	151734860	151734860	C	A	Nonsense_Mutation	p.E143*	2
MRPL9	CESC	chr1	151735518	151735518	C	A	Silent	p.T86	1
MRPL9	SARC	chr1	151735297	151735297	G	A	RNA	NULL	1
MRPL9	UCEC	chr1	151735576	151735576	T	-	Frame_Shift_Del	p.E67fs	1
MRPL9	BLCA	chr1	151733963	151733963	C	T	Silent	p.L184L	1
MRPL9	LIHC	chr1	151732544	151732544	G	-	Frame_Shift_Del	p.P262fs	1
MRPL9	COAD	chr1	151732618	151732618	C	T	Missense_Mutation	p.V238M	1
MRPL9	LIHC	chr1	151732601	151732601	G	-	Frame_Shift_Del	p.P243fs	1
MRPL9	COAD	chr1	151732620	151732620	A	G	Missense_Mutation	p.V237A	1
MRPL9	LIHC	chr1	151735885	151735885	C	-	Frame_Shift_Del	p.G25fs	1
MRPL9	COAD	chr1	151733327	151733327	T	C	Missense_Mutation	p.I213V	1
MRPL9	KIRC	chr1	151732588	151732588	A	T	Missense_Mutation	p.Y248N	1
MRPL9	CESC	chr1	151733335	151733335	T	G	Missense_Mutation		1
MRPL9	LUAD	chr1	151732528	151732528	A	T	Nonstop_Mutation	p.*268K	1
MRPL9	DLBC	chr1	151735913	151735913	G	A	Missense_Mutation	p.R15W	1
MRPL9	KIRC	chr1	151735551	151735551	C	T	Silent	p.R75R	1
MRPL9	LUAD	chr1	151732565	151732565	T	-	Frame_Shift_Del	p.Q255fs	1
MRPL9	ESCA	chr1	151734490	151734490	C	T	RNA	NULL	1
MRPL9	CESC	chr1	151735518	151735518	C	A	Silent		1
MRPL9	LUSC	chr1	151732535	151732535	G	C	Silent	p.P265P	1
MRPL9	ESCA	chr1	151735572	151735573	-	C	Frame_Shift_Ins	p.R69fs	1
MRPL9	KIRP	chr1	151735603	151735616	CGCTCCACGATGAC	-	Frame_Shift_Del	p.VIVER54fs	1
MRPL9	CESC	chr1	151734851	151734851	C	T	Splice_Site		1
MRPL9	LUSC	chr1	151732617	151732617	A	-	Frame_Shift_Del	p.V238fs	1
MRPL9	HNSC	chr1	151732598	151732598	C	A	Missense_Mutation		1
MRPL9	KIRP	chr1	151735603	151735616	CGCTCCACGATGAC	-	Frame_Shift_Del	p.54_58del	1
MRPL9	CESC	chr1	151733963	151733963	C	T	Silent		1
MRPL9	OV	chr1	150000577	150000577	T	C	Missense_Mutation		1
MRPL9	HNSC	chr1	151732587	151732587	T	C	Missense_Mutation		1
MRPL9	UCEC	chr1	151733292	151733292	C	T	Silent	p.T224_splice	1
MRPL9	KIRP	chr1	151735603	151735616	CGCTCCACGATGAC	-	Frame_Shift_Del	p.V54fs	1
MRPL9	CESC	chr1	151734851	151734851	C	T	Splice_Site	e3+1	1
MRPL9	SARC	chr1	151732538	151732538	G	T	Missense_Mutation		1
MRPL9	HNSC	chr1	151735515	151735515	C	T	Silent		1
MRPL9	BLCA	chr1	151733936	151733936	G	T	Missense_Mutation		1
MRPL9	LIHC	chr1	151734954	151734954	C	T	Silent		1
MRPL9	CESC	chr1	151733963	151733963	C	T	Silent	p.L184	1
MRPL9	SARC	chr1	151732554	151732554	G	T	Missense_Mutation		1
MRPL9	UCEC	chr1	151734859	151734860	-	C	Frame_Shift_Ins	p.E143fs	1
MRPL9	BLCA	chr1	151733936	151733936	G	T	Missense_Mutation	p.F193L	1
MRPL9	LIHC	chr1	151734628	151734628	T	C	Missense_Mutation		1

Copy number variation (CNV) of MRPL9
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL9
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96568	HNSC	TCGA-CN-4731	ANKFY1	chr17	4145550	-	MRPL9	chr1	151733375	-
96568	Non-Cancer	TCGA-BT-A20W-11A	ANXA9	chr1	150959137	+	MRPL9	chr1	151732657	-
96568	STAD	TCGA-CD-8525-01A	BCAM	chr19	45315805	+	MRPL9	chr1	151734028	-
96568	Non-Cancer	TCGA-IP-7968-11A	DCAF15	chr19	14065473	+	MRPL9	chr1	151734028	-
96568	N/A	BP431009	ELP4	chr11	31561238	+	MRPL9	chr1	151732583	+
91103	OV	TCGA-13-0765	MRPL9	chr1	151734580	-	CYBA	chr16	88712605	-
94663	N/A	AA700950	MRPL9	chr1	151734599	-	NCAM1	chr11	113148979	+
96051	STAD	TCGA-RD-A8N9	MRPL9	chr1	151733291	-	RBM5	chr3	50150815	+
98506	OV	TCGA-24-1428	MRPL9	chr1	151733291	-	RORC	chr1	151789756	-
100204	N/A	AI432441	MRPL9	chr1	151732422	+	RPS6KA2	chr6	166824834	-
96568	N/A	BM837406	STRN	chr2	37072134	-	MRPL9	chr1	151735972	-
96575	BLCA	TCGA-GU-A764-01A	UCK2	chr1	165797169	+	MRPL9	chr1	151734976	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
COAD	MRPL9	0.00327562718430628	0.092
ESCA	MRPL9	0.00685524336224175	0.19

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPL9	0.014378652707464	0.45
LUSC	MRPL9	0.0104975929699441	0.34
LGG	MRPL9	0.000404647279508591	0.013
PAAD	MRPL9	0.0285738280765235	0.83
UVM	MRPL9	0.0444012151703387	1
UCEC	MRPL9	0.048621940355047	1
ESCA	MRPL9	0.027606411753896	0.83

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human