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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: SECISBP2 (NCBI Gene ID:79048)

Gene Summary

Gene Summary

Gene Information	Gene Name: SECISBP2
	Gene ID: 79048
	Gene Symbol	SECISBP2
	Gene ID	79048
	Gene Name	SECIS binding protein 2
	Synonyms	SBP2
	Cytomap	9q22.2
	Type of Gene	protein-coding
	Description	selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2
	Modification date	20200313
	UniProtAcc	Q96T21

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
SECISBP2	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'SECISBP2[title] AND translation [title] AND human.'

Gene	Title	PMID
SECISBP2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000375807	91940341	91940591	Frame-shift
ENST00000375807	91949436	91949645	Frame-shift
ENST00000375807	91954778	91954868	In-frame
ENST00000375807	91964690	91964844	Frame-shift
ENST00000375807	91972325	91972480	Frame-shift
ENST00000375807	91972913	91973106	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000375807	91954778	91954868	3471	1284	1373	854	404	434

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q96T21	404	434	1	854	Chain	ID=PRO_0000097655;Note=Selenocysteine insertion sequence-binding protein 2
Q96T21	404	434	428	428	Natural variant	ID=VAR_061704;Note=Q->E;Dbxref=dbSNP:rs45452691

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	SECISBP2	-1.75320478083999	0.0244988885611231
PRAD	SECISBP2	1.87774240131642	5.80245434965193e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
ACC	SECISBP2	hsa-miR-181a-5p	87	-0.317989289191821	0.004454406570686
SKCM	SECISBP2	hsa-miR-24-3p	96	-0.330452775073028	0.00307101642400307

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
SARC	SECISBP2	1	2	0.0370837097708538	0.173141025641026	0.301729427083333	-0.174878178216431	0.0985614251490295

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
TGCT	SECISBP2	0.134407401	0.008105699
PRAD	SECISBP2	0.076431097	0.032578613

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with SECISBP2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Cell metabolism gene	SECISBP2	TRDMT1	0.804261952	2.61E-19
UVM	Cell metabolism gene	SECISBP2	PIK3CA	0.80920824	1.07E-19
UVM	Cell metabolism gene	SECISBP2	SLC44A1	0.823486616	6.85E-21
UVM	CGC	SECISBP2	ERCC4	0.806318449	1.81E-19
UVM	CGC	SECISBP2	PIK3CA	0.80920824	1.07E-19
UVM	CGC	SECISBP2	PALB2	0.810018538	9.17E-20
UVM	CGC	SECISBP2	ATR	0.81524597	3.44E-20
UVM	CGC	SECISBP2	MALT1	0.820133681	1.33E-20
UVM	CGC	SECISBP2	SETD2	0.823471934	6.87E-21
UVM	CGC	SECISBP2	RGPD3	0.82807845	2.69E-21
UVM	CGC	SECISBP2	STAG1	0.831864373	1.22E-21
UVM	Epifactor	SECISBP2	MGEA5	0.802983988	3.28E-19
UVM	Epifactor	SECISBP2	CHD6	0.807629876	1.42E-19
UVM	Epifactor	SECISBP2	ZMYND11	0.813165726	5.10E-20
UVM	Epifactor	SECISBP2	ATR	0.81524597	3.44E-20
UVM	Epifactor	SECISBP2	PHC3	0.815249994	3.43E-20
UVM	Epifactor	SECISBP2	SETD2	0.823471934	6.87E-21
UVM	Epifactor	SECISBP2	PPP4R2	0.829638774	1.94E-21
UVM	Epifactor	SECISBP2	SHPRH	0.831111959	1.43E-21
UVM	Epifactor	SECISBP2	USP46	0.832519561	1.06E-21
UVM	Epifactor	SECISBP2	MBIP	0.845563882	5.83E-23
UVM	Epifactor	SECISBP2	TOP2B	0.857148255	3.51E-24
UVM	IUPHAR	SECISBP2	NR2C2	0.806529232	1.74E-19
UVM	IUPHAR	SECISBP2	PIK3CA	0.80920824	1.07E-19
UVM	IUPHAR	SECISBP2	ZMYND11	0.813165726	5.10E-20
UVM	IUPHAR	SECISBP2	ATR	0.81524597	3.44E-20
UVM	IUPHAR	SECISBP2	NEK4	0.816593711	2.65E-20
UVM	IUPHAR	SECISBP2	MALT1	0.820133681	1.33E-20
UVM	IUPHAR	SECISBP2	SETD2	0.823471934	6.87E-21
UVM	IUPHAR	SECISBP2	SLC44A1	0.823486616	6.85E-21
UVM	IUPHAR	SECISBP2	ATP11B	0.85998953	1.70E-24
UVM	Kinase	SECISBP2	ICK	0.801022699	4.64E-19
UVM	Kinase	SECISBP2	ATR	0.81524597	3.44E-20
UVM	Kinase	SECISBP2	NEK4	0.816593711	2.65E-20
UVM	TF	SECISBP2	TMF1	0.800993808	4.66E-19
UVM	TF	SECISBP2	ZNF41	0.801134091	4.55E-19
UVM	TF	SECISBP2	HBP1	0.802375181	3.66E-19
UVM	TF	SECISBP2	ZNF320	0.80318705	3.17E-19
UVM	TF	SECISBP2	NR2C2	0.806529232	1.74E-19
UVM	TF	SECISBP2	ZNF426	0.811810703	6.57E-20
UVM	TF	SECISBP2	ZNF782	0.811812442	6.57E-20
UVM	TF	SECISBP2	ZFP14	0.813465614	4.82E-20
UVM	TF	SECISBP2	ZNF347	0.814228377	4.17E-20
UVM	TF	SECISBP2	ZNF813	0.815132494	3.51E-20
UVM	TF	SECISBP2	BBX	0.815180973	3.48E-20
UVM	TF	SECISBP2	ZNF407	0.817026537	2.44E-20
UVM	TF	SECISBP2	ZBTB11	0.82074006	1.18E-20
UVM	TF	SECISBP2	ZNF160	0.822959351	7.62E-21
UVM	TF	SECISBP2	ZNF558	0.825050301	5.00E-21
UVM	TF	SECISBP2	ZNF621	0.825882483	4.22E-21
UVM	TF	SECISBP2	ZNF611	0.847275513	3.90E-23
UVM	TF	SECISBP2	ZNF844	0.856788411	3.84E-24
UVM	TSG	SECISBP2	HBP1	0.802375181	3.66E-19
UVM	TSG	SECISBP2	HACE1	0.804298964	2.60E-19
UVM	TSG	SECISBP2	NR2C2	0.806529232	1.74E-19
UVM	TSG	SECISBP2	PALB2	0.810018538	9.17E-20
UVM	TSG	SECISBP2	ZMYND11	0.813165726	5.10E-20
UVM	TSG	SECISBP2	ATR	0.81524597	3.44E-20
UVM	TSG	SECISBP2	PHC3	0.815249994	3.43E-20
UVM	TSG	SECISBP2	SETD2	0.823471934	6.87E-21
UVM	TSG	SECISBP2	SHPRH	0.831111959	1.43E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	SECISBP2	TRNAU1AP	-1.56635696696237	0.000137265065605683
BLCA	SECISBP2	SEPHS2	-1.9883328839393	0.000209808349609375
LUSC	SECISBP2	SEPN1	-1.37986364526998	0.000778331171335384
BRCA	SECISBP2	SEPSECS	-1.49569251700223	0.000941794422102645
KIRP	SECISBP2	DIO2	1.91579966070365	0.000980085227638483
COAD	SECISBP2	PSTK	-2.83493023793761	0.00197160243988037
LUSC	SECISBP2	PSTK	-1.10450833392405	0.00201130880831994
PRAD	SECISBP2	PSTK	1.42484344304779	0.00312472017787764
CHOL	SECISBP2	SEPHS2	-1.45963342788287	0.00390625
CHOL	SECISBP2	SEPSECS	-1.79794121924099	0.00390625
STAD	SECISBP2	SEPN1	1.56665495974194	0.00828406633809209
HNSC	SECISBP2	SEPN1	-1.03807164549515	0.017158825403385
COAD	SECISBP2	SEPHS2	-1.01516153437197	0.0189773440361023
COAD	SECISBP2	SEPSECS	-1.79606545257874	0.023610919713974
CHOL	SECISBP2	TRNAU1AP	-1.36228203168816	0.02734375
UCEC	SECISBP2	SEPHS2	-3.10798770240601	0.03125
READ	SECISBP2	EEFSEC	-2.14513057008022	0.03125
LUAD	SECISBP2	RPL30	-1.98579595284099	1.50488235365288e-05
THCA	SECISBP2	TRNAU1AP	-2.34899508686103	1.55290879513537e-06
COAD	SECISBP2	EEFSEC	-9.71610086929807	1.59740447998047e-05
HNSC	SECISBP2	DIO2	-1.03837900519137	1.63011400218238e-05
BRCA	SECISBP2	DIO2	1.30249259220534	1.7498244905122e-06
PRAD	SECISBP2	SEPHS2	-1.35334370834684	3.09428010368575e-05
KIRC	SECISBP2	DIO2	1.46798091921338	3.24635122520647e-05
KIRC	SECISBP2	SEPHS2	-1.2281351725597	5.81016338316469e-09
KIRC	SECISBP2	PSTK	2.45946657502431	7.59244533881681e-10
LUSC	SECISBP2	RPL30	-2.27386662283158	9.09971457907932e-05
KIRC	SECISBP2	RPL30	-1.65763742142219	9.40007073737459e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with SECISBP2

ATXN7L3, APP, SMAD9, GOLGA2, PCM1, SPICE1, TRIM25, EGLN3, RC3H2, FAM168A, CCT6A, HIST1H2AH, N, nsp3, CELF1, DAZL, EIF4ENIF1, FAM120C, FUBP3, FXR1, IGF2BP1, IGF2BP2, LARP4B, LSM14A, LZTS2, MEX3B, MKRN2, MOV10, OTUD4, PABPC1, PRRC2A, PUM1, R3HDM2, RBM47, RBMS1, STAU1, TDRD3, UBAP2L, YTHDF1, YTHDF2, YTHDF3, ZC3HAV1, ZFP36, ANKRD17, CAPRIN1, CSDE1, DDX3X, FMR1, PATL1, SAMD4B, ZC3H7A, SMG7, SYNCRIP, PAIP2, RNF214, TOP3B, XRN1, CIT, RHOT2, RMDN3, FBL, MAPRE3, RPS20, SYNE3, TRIM36, NUDCD2, PIP, MYO18A, KCNE3, TNFRSF1B, QKI, TRNAU1AP, DMRTB1, Cdc42, Htatsf1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
SECISBP2	chr9	91934667	C	G	single_nucleotide_variant	Uncertain_significance	Thyroid_hormone_metabolism,_abnormal	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
SECISBP2	chr9	91934713	G	A	single_nucleotide_variant	Likely_pathogenic	Thyroid_hormone_metabolism,_abnormal	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
SECISBP2	chr9	91940440	CT	C	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001589\|frameshift_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
SECISBP2	chr9	91940581	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
SECISBP2	chr9	91943589	C	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001587\|nonsense,SO:0001623\|5_prime_UTR_variant	SO:0001587\|nonsense,SO:0001623\|5_prime_UTR_variant
SECISBP2	chr9	91943695	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
SECISBP2	chr9	91943699	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
SECISBP2	chr9	91943797	C	CA	Duplication	Pathogenic	Thyroid_hormone_metabolism,_abnormal	SO:0001589\|frameshift_variant,SO:0001623\|5_prime_UTR_variant	SO:0001589\|frameshift_variant,SO:0001623\|5_prime_UTR_variant
SECISBP2	chr9	91953524	G	A	single_nucleotide_variant	Pathogenic	Thyroid_hormone_metabolism,_abnormal	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SECISBP2	chr9	91954841	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
SECISBP2	chr9	91956271	A	T	single_nucleotide_variant	Pathogenic	Thyroid_hormone_metabolism,_abnormal	SO:0001587\|nonsense	SO:0001587\|nonsense
SECISBP2	chr9	91956345	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SECISBP2	chr9	91956347	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SECISBP2	chr9	91961836	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SECISBP2	chr9	91961941	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SECISBP2	chr9	91963010	G	A	single_nucleotide_variant	Pathogenic	Thyroid_hormone_metabolism,_abnormal	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SECISBP2	chr9	91963136	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SECISBP2	chr9	91965577	G	A	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SECISBP2	chr9	91972407	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SECISBP2	chr9	91972952	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SECISBP2	chr9	91972961	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SECISBP2	chr9	91973628	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
SECISBP2	KIRP	chr9	91965762	91965762	C	T	Missense_Mutation	p.S703L	6
SECISBP2	LGG	chr9	91964707	91964707	C	T	Silent	p.D585D	6
SECISBP2	UCS	chr9	91964840	91964840	A	G	Missense_Mutation	p.R630G	3
SECISBP2	ESCA	chr9	91940893	91940893	A	G	Missense_Mutation	p.I172V	3
SECISBP2	KIRP	chr9	91964729	91964729	G	A	Missense_Mutation	p.V593I	3
SECISBP2	ESCA	chr9	91972418	91972418	C	T	Missense_Mutation	p.R736C	3
SECISBP2	LIHC	chr9	91943618	91943618	A	-	Frame_Shift_Del	p.A206fs	3
SECISBP2	UCEC	chr9	91940437	91940437	C	G	Missense_Mutation	p.S93C	3
SECISBP2	ACC	chr9	91949587	91949587	C	T	Missense_Mutation	p.A344V	3
SECISBP2	ESCA	chr9	91972418	91972418	C	T	Missense_Mutation		3
SECISBP2	LGG	chr9	91964707	91964707	C	T	Silent		3
SECISBP2	CESC	chr9	91973638	91973638	G	A	Missense_Mutation		2
SECISBP2	UCEC	chr9	91934606	91934606	A	G	Missense_Mutation	p.R26G	2
SECISBP2	SKCM	chr9	91949551	91949551	C	T	Missense_Mutation	p.A332V	2
SECISBP2	LUAD	chr9	91943595	91943595	G	T	Missense_Mutation	p.D199Y	2
SECISBP2	CESC	chr9	91964815	91964815	C	G	Missense_Mutation		2
SECISBP2	KIRP	chr9	91965762	91965762	C	T	Missense_Mutation		2
SECISBP2	UCEC	chr9	91934609	91934609	T	G	Missense_Mutation	p.F27V	2
SECISBP2	LUAD	chr9	91943726	91943726	G	T	Missense_Mutation	p.W242C	2
SECISBP2	STAD	chr9	91964831	91964831	C	T	Missense_Mutation		2
SECISBP2	CESC	chr9	91972358	91972358	G	A	Missense_Mutation		2
SECISBP2	HNSC	chr9	91953402	91953402	A	T	Missense_Mutation	p.E373D	2
SECISBP2	UCEC	chr9	91940541	91940541	C	T	Nonsense_Mutation	p.R128*	2
SECISBP2	SKCM	chr9	91964815	91964815	C	T	Silent	p.F621F	2
SECISBP2	STAD	chr9	91964831	91964831	C	T	Missense_Mutation	p.R627C	2
SECISBP2	UCEC	chr9	91940542	91940542	G	A	Missense_Mutation	p.R128Q	2
SECISBP2	SKCM	chr9	91949602	91949602	C	T	Missense_Mutation	p.P349L	2
SECISBP2	LUAD	chr9	91943769	91943769	G	C	Missense_Mutation	p.E257Q	2
SECISBP2	STAD	chr9	91954828	91954828	G	A	Missense_Mutation	p.R421K	2
SECISBP2	LGG	chr9	91954798	91954798	A	G	Missense_Mutation	p.N411S	2
SECISBP2	UCEC	chr9	91940885	91940885	C	A	Nonsense_Mutation	p.S169*	2
SECISBP2	ESCA	chr9	91965627	91965627	G	A	Missense_Mutation	p.R658H	2
SECISBP2	SKCM	chr9	91961898	91961898	C	T	Missense_Mutation	p.P513S	2
SECISBP2	BLCA	chr9	91963047	91963047	G	A	Silent	p.V552V	2
SECISBP2	LUAD	chr9	91940394	91940394	C	T	Nonsense_Mutation	p.Q79*	2
SECISBP2	STAD	chr9	91964832	91964832	G	A	Missense_Mutation	p.R627H	2
SECISBP2	HNSC	chr9	91973689	91973689	G	A	Missense_Mutation	p.E839K	2
SECISBP2	UCEC	chr9	91940937	91940937	G	A	Silent	p.E186	2
SECISBP2	ESCA	chr9	91940488	91940488	A	G	Missense_Mutation	p.Q110R	2
SECISBP2	SKCM	chr9	91949601	91949601	C	T	Missense_Mutation	p.P349S	2
SECISBP2	HNSC	chr9	91963111	91963111	G	A	Missense_Mutation	p.E574K	2
SECISBP2	UCEC	chr9	91943758	91943758	C	A	Missense_Mutation	p.S253Y	2
SECISBP2	STAD	chr9	91956314	91956315	-	G	Frame_Shift_Ins	p.L452fs	2
SECISBP2	SARC	chr9	91964806	91964806	C	T	Silent		2
SECISBP2	LIHC	chr9	91973069	91973069	C	-	Frame_Shift_Del	p.G808fs	2
SECISBP2	UCEC	chr9	91943768	91943770	AGA	-	In_Frame_Del	p.E257in_frame_del	2
SECISBP2	ESCA	chr9	91940893	91940893	A	G	Missense_Mutation		2
SECISBP2	TGCT	chr9	91940430	91940430	G	A	Missense_Mutation		2
SECISBP2	LGG	chr9	91954798	91954798	A	G	Missense_Mutation		2
SECISBP2	UCEC	chr9	91949453	91949453	A	G	Silent	p.P299	2
SECISBP2	BLCA	chr9	91972404	91972404	G	A	Missense_Mutation	p.R731H	2
SECISBP2	TGCT	chr9	91940430	91940430	G	A	Missense_Mutation	p.A91T	2
SECISBP2	UCEC	chr9	91973099	91973099	A	G	Silent	p.P818	2
SECISBP2	BRCA	chr9	91934622	91934622	A	G	Missense_Mutation	p.N31S	2
SECISBP2	COAD	chr9	91943617	91943618	-	A	Frame_Shift_Ins	p.A206fs	2
SECISBP2	KIRC	chr9	91972394	91972394	G	A	Missense_Mutation	p.A728T	2
SECISBP2	SKCM	chr9	91961818	91961818	C	T	Missense_Mutation	p.S486F	2
SECISBP2	UCEC	chr9	91973698	91973698	T	G	Missense_Mutation	p.L842V	2
SECISBP2	HNSC	chr9	91973672	91973672	G	C	Missense_Mutation		1
SECISBP2	LUAD	chr9	91943573	91943573	A	T	Splice_Site	p.D192_splice	1
SECISBP2	THCA	chr9	91963110	91963110	C	A	Silent		1
SECISBP2	COAD	chr9	91947846	91947846	C	T	Silent	p.N275N	1
SECISBP2	KIRC	chr9	91965698	91965715	AAACACCTGAAGCTCAAA	-	In_Frame_Del	p.KHLKLK682del	1
SECISBP2	LIHC	chr9	91940828	91940828	A	G	Missense_Mutation		1
SECISBP2	SKCM	chr9	91949501	91949501	C	T	Silent	p.A315A	1
SECISBP2	UCS	chr9	91964840	91964840	A	G	Missense_Mutation		1
SECISBP2	BLCA	chr9	91963078	91963078	G	C	Missense_Mutation		1
SECISBP2	GBM	chr9	91973081	91973081	G	A	Silent		1
SECISBP2	HNSC	chr9	91972401	91972401	A	T	Missense_Mutation	p.N730I	1
SECISBP2	LUSC	chr9	91940430	91940430	G	T	Missense_Mutation	p.A91S	1
SECISBP2	THCA	chr9	91954833	91954833	G	C	Missense_Mutation	p.E423Q	1
SECISBP2	COAD	chr9	91972403	91972403	C	T	Missense_Mutation	p.R731C	1
SECISBP2	KIRC	chr9	91956314	91956315	-	G	Frame_Shift_Ins	p.W452fs	1
SECISBP2	LIHC	chr9	91965617	91965617	T	C	Missense_Mutation		1
SECISBP2	SKCM	chr9	91954840	91954840	C	A	Missense_Mutation	p.P425Q	1
SECISBP2	BLCA	chr9	91972404	91972404	G	A	Missense_Mutation		1
SECISBP2	GBM	chr9	91949596	91949596	C	T	Missense_Mutation		1
SECISBP2	KIRP	chr9	91964729	91964729	G	A	Missense_Mutation		1
SECISBP2	OV	chr9	91137694	91137694	G	A	Missense_Mutation		1
SECISBP2	THYM	chr9	91965654	91965654	C	A	Missense_Mutation		1
SECISBP2	DLBC	chr9	91954848	91954848	C	G	Missense_Mutation	p.Q428E	1
SECISBP2	KIRC	chr9	91943570	91943574	TACAG	-	Splice_Site		1
SECISBP2	LIHC	chr9	91961926	91961926	A	G	Missense_Mutation		1
SECISBP2	LUAD	chr9	91943573	91943573	A	T	Splice_Site		1
SECISBP2	BLCA	chr9	91934667	91934667	C	T	Missense_Mutation		1
SECISBP2	GBM	chr9	91972948	91972948	C	T	Missense_Mutation		1
SECISBP2	CESC	chr9	91939384	91939384	C	T	RNA	NULL	1
SECISBP2	HNSC	chr9	91963071	91963071	C	T	Silent	p.D560D	1
SECISBP2	KIRP	chr9	91943782	91943782	C	A	Missense_Mutation		1
SECISBP2	OV	chr9	91940489	91940489	G	C	Missense_Mutation	p.Q110H	1
SECISBP2	THYM	chr9	91972368	91972368	G	T	Missense_Mutation		1
SECISBP2	LIHC	chr9	91956303	91956303	G	A	Silent		1
SECISBP2	HNSC	chr9	91963071	91963071	C	T	Silent		1
SECISBP2	BLCA	chr9	91934652	91934652	G	A	Missense_Mutation	p.C41Y	1
SECISBP2	CESC	chr9	91964815	91964815	C	G	Missense_Mutation	p.F621L	1
SECISBP2	HNSC	chr9	91973672	91973672	G	C	Missense_Mutation	p.G833A	1
SECISBP2	OV	chr9	91943768	91943768	A	G	Silent	p.R256	1
SECISBP2	THYM	chr9	91965610	91965610	G	T	Silent	p.L652L	1
SECISBP2	KIRP	chr9	91961869	91961869	C	-	Frame_Shift_Del	p.T503fs	1
SECISBP2	LIHC	chr9	91943603	91943603	A	G	Silent		1
SECISBP2	HNSC	chr9	91963111	91963111	G	A	Missense_Mutation		1
SECISBP2	STAD	chr9	91972374	91972374	A	G	Missense_Mutation	p.Q721R	1
SECISBP2	CESC	chr9	91972358	91972358	G	A	Missense_Mutation	p.D716N	1
SECISBP2	LGG	chr9	91940432	91940432	C	A	Silent	p.A91A	1
SECISBP2	PRAD	chr9	91940523	91940523	T	G	Missense_Mutation	p.F122V	1
SECISBP2	THYM	chr9	91940373	91940373	G	T	Nonsense_Mutation	p.G72X	1
SECISBP2	LIHC	chr9	91940370	91940370	T	G	Missense_Mutation	p.F71V	1
SECISBP2	BLCA	chr9	91940549	91940549	G	C	Missense_Mutation	p.E130D	1
SECISBP2	HNSC	chr9	91973689	91973689	G	A	Missense_Mutation		1
SECISBP2	LUAD	chr9	91956281	91956281	T	C	Missense_Mutation	p.V441A	1
SECISBP2	STAD	chr9	91964693	91964693	C	T	Missense_Mutation	p.P581S	1
SECISBP2	STAD	chr9	91964783	91964783	G	A	Missense_Mutation	p.A611T	1
SECISBP2	CESC	chr9	91973638	91973638	G	A	Missense_Mutation	p.E822K	1
SECISBP2	PRAD	chr9	91972384	91972384	C	A	Silent	p.P724P	1
SECISBP2	THYM	chr9	91961933	91961933	C	A	Silent	p.P524P	1
SECISBP2	SKCM	chr9	91972354	91972354	T	G	Missense_Mutation	p.I714M	1
SECISBP2	BLCA	chr9	91940437	91940437	C	T	Missense_Mutation	p.S93F	1
SECISBP2	HNSC	chr9	91953402	91953402	A	T	Missense_Mutation		1
SECISBP2	LUAD	chr9	91943612	91943612	C	G	Missense_Mutation	p.I204M	1
SECISBP2	STAD	chr9	91956315	91956316	-	G	Frame_Shift_Ins	p.L452fs	1
SECISBP2	CHOL	chr9	91943787	91943787	G	T	Missense_Mutation		1
SECISBP2	HNSC	chr9	91940847	91940847	G	-	Frame_Shift_Del	p.Q157fs	1
SECISBP2	LGG	chr9	91963028	91963028	G	A	Missense_Mutation	p.R546H	1
SECISBP2	SKCM	chr9	91954794	91954794	C	T	Missense_Mutation	p.P410S	1
SECISBP2	BLCA	chr9	91963078	91963078	G	C	Missense_Mutation	p.D563H	1
SECISBP2	HNSC	chr9	91940847	91940847	G	-	Frame_Shift_Del		1
SECISBP2	LUAD	chr9	91961840	91961840	G	C	Missense_Mutation	p.E493D	1
SECISBP2	STAD	chr9	91949479	91949479	T	C	Missense_Mutation	p.L308S	1
SECISBP2	COAD	chr9	91940838	91940838	G	A	Silent	p.T153T	1
SECISBP2	KIRC	chr9	91961828	91961831	TGCA	-	Frame_Shift_Del	p.489_490del	1
SECISBP2	SARC	chr9	91964806	91964806	C	T	Silent	p.H618H	1
SECISBP2	UCEC	chr9	91973099	91973099	A	G	Silent	p.P818P	1
SECISBP2	LIHC	chr9	91965698	91965698	A	-	Frame_Shift_Del	p.K682fs	1
SECISBP2	SKCM	chr9	91943605	91943605	C	T	Missense_Mutation	p.S202F	1
SECISBP2	BLCA	chr9	91934652	91934652	G	A	Missense_Mutation		1
SECISBP2	ESCA	chr9	91965627	91965627	G	A	Missense_Mutation		1
SECISBP2	HNSC	chr9	91940849	91940849	A	C	Missense_Mutation		1
SECISBP2	LUAD	chr9	91963091	91963091	G	A	Missense_Mutation	p.G567D	1
SECISBP2	COAD	chr9	91943646	91943646	T	G	Missense_Mutation	p.F216V	1
SECISBP2	KIRC	chr9	91965698	91965715	AAACACCTGAAGCTCAAA	-	In_Frame_Del	p.681_687del	1
SECISBP2	LGG	chr9	91940432	91940432	C	A	Silent		1
SECISBP2	SARC	chr9	91964806	91964806	C	T	Silent	p.H618	1
SECISBP2	UCEC	chr9	91965712	91965713	-	A	Frame_Shift_Ins	p.L686fs	1
SECISBP2	LIHC	chr9	91949500	91949500	C	-	Frame_Shift_Del	p.A315fs	1
SECISBP2	SKCM	chr9	91947859	91947859	G	A	Missense_Mutation	p.V280I	1
SECISBP2	BLCA	chr9	91940549	91940549	G	C	Missense_Mutation		1
SECISBP2	HNSC	chr9	91972401	91972401	A	T	Missense_Mutation		1
SECISBP2	LUAD	chr9	91943789	91943789	A	T	Silent	p.A263A	1
SECISBP2	THCA	chr9	91954833	91954833	G	C	Missense_Mutation		1
SECISBP2	UCEC	chr9	91943768	91943770	AGA	-	In_Frame_Del	p.E257del	1
SECISBP2	LIHC	chr9	91972430	91972430	A	-	Frame_Shift_Del	p.K740fs	1
SECISBP2	SKCM	chr9	91953452	91953452	C	T	Missense_Mutation	p.S390L	1
SECISBP2	BLCA	chr9	91940437	91940437	C	T	Missense_Mutation		1
SECISBP2	GBM	chr9	91973081	91973081	G	A	Silent	p.L812L	1

Copy number variation (CNV) of SECISBP2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across SECISBP2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99349	N/A	BC038854	HIST1H2BC	chr6	26123741	-	SECISBP2	chr9	91972326	+
99349	N/A	AA837640	MRC2	chr17	60770843	-	SECISBP2	chr9	91940369	-
100996	N/A	DB133597	SECISBP2	chr9	91934712	+	ENY2	chr8	110355634	+
101403	UCEC	TCGA-D1-A3DG	SECISBP2	chr9	91934712	+	GNAI3	chr1	110116358	+
96760	ESCA	TCGA-L5-A4OM	SECISBP2	chr9	91934712	+	HSPH1	chr13	31719905	-
80192	N/A	AX053295	SECISBP2	chr9	91943733	+	LBX1-AS1	chr10	103027551	+
100295	N/A	HI518920	SECISBP2	chr9	91953434	+	LPP	chr3	188243069	-
103282	N/A	BQ182443	SECISBP2	chr9	91974167	-	MYH9	chr22	36678569	+
102301	LUAD	TCGA-86-8075	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063398	+
102301	LUAD	TCGA-86-8075-01A	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
86748	N/A	AK125614	SECISBP2	chr9	91973037	+	RBM3	chrX	48434778	+
94651	OV	TCGA-24-1923	SECISBP2	chr9	91934712	+	RIF1	chr2	152315324	+
99349	N/A	AU253387	SECISBP2	chr9	91949494	-	SECISBP2	chr9	91954864	-
99349	N/A	CV416238	SECISBP2	chr9	91939671	+	SECISBP2	chr9	91939346	-
93333	Non-Cancer	TCGA-EJ-7785-11A	SECISBP2	chr9	91934712	+	TOP2B	chr3	25656779	-
89639	STAD	TCGA-D7-5577-01A	SECISBP2	chr9	91934712	+	TPI1	chr12	6978422	+
99351	LUSC	TCGA-22-5483-01A	WNK2	chr9	96026315	+	SECISBP2	chr9	91972326	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LUSC	SECISBP2	1.29229041090514	0.256416156344382	0.000136225409537631	0.000250838969259076	0.000129456123233205	545
SKCM	SECISBP2	0.779814212402275	-0.248699576897911	0.00112536909081141	0.00156785245847934	0.00112247728205648	462
SKCM	SECISBP2	0.779814212402275	-0.248699576897911	0.00112536909081141	0.00156785245847934	0.00112247728205648	462
ACC	SECISBP2	0.413903728468914	-0.882121872128584	0.00590848045913735	0.00821347613909579	0.00560876518263499	79
OV	SECISBP2	1.36074769763708	0.308034326349905	0.0262270142572348	0.0240979733523618	0.0263503256494616	307
THCA	SECISBP2	2.85445790742976	1.04888195027378	0.0305919163196361	0.022526674012398	0.0408893684397861	571
THCA	SECISBP2	2.85445790742976	1.04888195027378	0.0305919163196361	0.022526674012398	0.0408893684397861	571
CESC	SECISBP2	1.39591705392488	0.33355158561567	0.0474431123561847	0.0385996324409987	0.0499382471084021	295
KIRC	SECISBP2	0.722676173477165	-0.32479404999666	4.06290313336189e-06	0.000105179041226319	8.76130480825832e-06	604
KIRC	SECISBP2	0.722676173477165	-0.32479404999666	4.06290313336189e-06	0.000105179041226319	8.76130480825832e-06	604
BRCA	SECISBP2	1.47584046789477	0.389227636254639	4.07730931528054e-05	3.33104312179305e-05	4.51247481061969e-05	1200

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SKCM	SECISBP2	0.00239611748165657	0.067
TGCT	SECISBP2	0.00532321491734708	0.14
THCA	SECISBP2	0.00736976380950581	0.19
KIRC	SECISBP2	0.0113702289178387	0.28
LUAD	SECISBP2	0.0223037675589531	0.54

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	SECISBP2	0.0343393035397836	1
THYM	SECISBP2	0.0364591926594231	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1864761	Thyroid Hormone Metabolism, Abnormal	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0750905	Amino Acid Metabolism, Inherited Disorders	1	CTD_human