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Translation Factor: DNAJC5 (NCBI Gene ID:80331) |
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Gene Summary |
Gene Information | Gene Name: DNAJC5 | Gene ID: 80331 | Gene Symbol | DNAJC5 | Gene ID | 80331 |
Gene Name | DnaJ heat shock protein family (Hsp40) member C5 | |
Synonyms | CLN4|CLN4B|CSP|DNAJC5A|NCL|mir-941-2|mir-941-3|mir-941-4|mir-941-5 | |
Cytomap | 20q13.33 | |
Type of Gene | protein-coding | |
Description | dnaJ homolog subfamily C member 5DnaJ (Hsp40) homolog, subfamily C, member 5ceroid-lipofuscinosis neuronal protein 4cysteine string protein alpha | |
Modification date | 20200328 | |
UniProtAcc | . |
Child GO biological process term(s) under GO:0006412 |
GO ID | GO term |
Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Inferred gene age of translation factor. |
Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
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We searched PubMed using 'DNAJC5[title] AND translation [title] AND human.' |
Gene | Title | PMID |
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Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
Exon skipping position in the amino acid sequence. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
Potentially (partially) lost protein functional features of UniProt. |
UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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Gene expression level across TCGA pancancer |
Gene expression level across GTEx pantissue |
Expression level of gene isoforms across TCGA pancancer |
Expression level of gene isoforms across GTEx pantissue |
Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
Cancer type | Translation factor | FC | adj.pval |
CHOL | DNAJC5 | -2.43712099937437 | 0.00390625 |
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Translation factor expression regulation through miRNA binding |
Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
Translation factor expression regulation through methylation in the promoter of Translation factor |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through copy number variation of Translation factor |
Cancer type | Gene | Coefficient | Pvalue |
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Strongly correlated genes belong to cellular important gene groups with DNAJC5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
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Protein 3D structure Visit iCn3D. |
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Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
* Edge colors based on TCGA cancer types. |
* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
PPI interactors with DNAJC5 |
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Clinically associated variants from ClinVar. |
Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
SNVs and Indels |
Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
Copy number variation (CNV) of DNAJC5 * Click on the image to open the original image in a new window. |
Fusion gene breakpoints (product of the structural variants (SVs)) across DNAJC5 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion genes with this translation factor from FusionGDB2.0. |
FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
97120 | N/A | BE067370 | DNAJC5 | chr20 | 62540998 | - | CLASRP | chr19 | 45272525 | + |
93728 | N/A | AA527968 | DNAJC5 | chr20 | 62546791 | + | CLVS1 | chr8 | 62146095 | + |
86482 | N/A | EC457325 | DNAJC5 | chr20 | 62546014 | - | CPNE5 | chr6 | 36799340 | + |
93295 | N/A | AW850806 | DNAJC5 | chr20 | 62534626 | + | DNAJC5 | chr20 | 62528912 | + |
93295 | N/A | AW855153 | DNAJC5 | chr20 | 62142783 | - | DNAJC5 | chr20 | 62531658 | + |
99417 | N/A | BE818200 | DNAJC5 | chr20 | 62565964 | - | MED1 | chr17 | 37563951 | - |
101200 | COAD | TCGA-A6-2674 | DNAJC5 | chr20 | 62562375 | + | PRPF6 | chr20 | 62614399 | + |
78511 | N/A | EC441428 | DNAJC5 | chr20 | 62532433 | - | RTEL1-TNFRSF6B | chr20 | 62298270 | - |
96079 | OV | TCGA-24-1428 | DNAJC5 | chr20 | 62562375 | + | TPD52L2 | chr20 | 62500648 | + |
96079 | OV | TCGA-24-1428-01A | DNAJC5 | chr20 | 62562375 | + | TPD52L2 | chr20 | 62500649 | + |
93295 | N/A | AW372867 | ELK4 | chr1 | 205589416 | - | DNAJC5 | chr20 | 62532466 | + |
93295 | LUSC | TCGA-39-5030 | IGHG1 | chr14 | 106134587 | - | DNAJC5 | chr20 | 62526585 | + |
93295 | BRCA | TCGA-A8-A07O-01A | PCMTD2 | chr20 | 62899363 | + | DNAJC5 | chr20 | 62559688 | + |
93295 | N/A | BG981391 | PIGR | chr1 | 207110597 | - | DNAJC5 | chr20 | 62566666 | + |
93295 | LUAD | TCGA-91-7771-01A | PRPF6 | chr20 | 62626835 | + | DNAJC5 | chr20 | 62562204 | + |
93295 | STAD | TCGA-BR-4280 | SLCO4A1 | chr20 | 61273905 | + | DNAJC5 | chr20 | 62559687 | + |
93300 | Non-Cancer | TCGA-BH-A0AY-11A | TPD52L2 | chr20 | 62505169 | + | DNAJC5 | chr20 | 62559687 | + |
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Kaplan-Meier plots with logrank tests of overall survival (OS) |
Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
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Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
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Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Diseases associated with this translation factor. (DisGeNet 4.0) |
Disease ID | Disease Name | # PubMeds | Disease source |