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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: SARNP (NCBI Gene ID:84324)

Gene Summary

Gene Summary

Gene Information	Gene Name: SARNP
	Gene ID: 84324
	Gene Symbol	SARNP
	Gene ID	84324
	Gene Name	SAP domain containing ribonucleoprotein
	Synonyms	CIP29\|HCC1\|HSPC316\|THO1
	Cytomap	12q13.2
	Type of Gene	protein-coding
	Description	SAP domain-containing ribonucleoproteincytokine induced protein 29 kDacytokine-induced protein of 29 kDahepatocellular carcinoma 1nuclear protein Hcc-1proliferation associated cytokine-inducible protein CIP29
	Modification date	20200313
	UniProtAcc	P82979

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SARNP	GO:0006406	mRNA export from nucleus	20844015

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'SARNP[title] AND translation [title] AND human.'

Gene	Title	PMID
SARNP	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000336133	56194637	56194684	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	SARNP	-1.36357226720204	0.00828406633809209
UCEC	SARNP	1.44617934285218	0.03125
BRCA	SARNP	-3.14252975671143	4.58760516408467e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LIHC	SARNP	hsa-miR-16-2-3p	97	0.358983122141017	0.00143593541243135

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LIHC	SARNP	2	1	0.015514949905748	0.204298333333333	0.191542084377611	0.24324873715648	0.552719062970913

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	SARNP	0.158049615	0.00054862
GBM	SARNP	0.340599754	0.006094388
OV	SARNP	-0.098976422	0.030281272
CHOL	SARNP	0.047719356	0.048350082
MESO	SARNP	0.059003067	0.048531058

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with SARNP (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	SARNP	TBCB	0.820521662	5.24E-12
CHOL	Cell metabolism gene	SARNP	PFDN1	0.820605233	5.19E-12
CHOL	Epifactor	SARNP	SIRT6	0.850359641	1.44E-13
CHOL	IUPHAR	SARNP	DYRK1B	0.826107913	2.82E-12
CHOL	IUPHAR	SARNP	MFSD5	0.828587461	2.13E-12
CHOL	IUPHAR	SARNP	SIRT6	0.850359641	1.44E-13
CHOL	Kinase	SARNP	DYRK1B	0.826107913	2.82E-12
CHOL	TF	SARNP	HES4	0.801231628	3.83E-11
CHOL	TSG	SARNP	SIRT6	0.850359641	1.44E-13
DLBC	Cell metabolism gene	SARNP	TPI1	0.803241404	6.43E-12
DLBC	Cell metabolism gene	SARNP	TOMM22	0.803338533	6.36E-12
DLBC	Cell metabolism gene	SARNP	TIMM50	0.805446159	5.09E-12
DLBC	Cell metabolism gene	SARNP	PFDN5	0.807159429	4.24E-12
DLBC	Cell metabolism gene	SARNP	TIMM13	0.809066072	3.45E-12
DLBC	Cell metabolism gene	SARNP	TBCA	0.810953355	2.80E-12
DLBC	Cell metabolism gene	SARNP	PSMC1	0.815317724	1.72E-12
DLBC	Cell metabolism gene	SARNP	NME2	0.818850377	1.15E-12
DLBC	Cell metabolism gene	SARNP	HSD17B10	0.822227244	7.76E-13
DLBC	Cell metabolism gene	SARNP	SEC61G	0.824450075	5.96E-13
DLBC	Cell metabolism gene	SARNP	POLR2L	0.824594633	5.86E-13
DLBC	Cell metabolism gene	SARNP	PSMC5	0.826442199	4.69E-13
DLBC	Cell metabolism gene	SARNP	PSMA7	0.82970949	3.14E-13
DLBC	Cell metabolism gene	SARNP	PSMC3	0.830127875	2.98E-13
DLBC	Cell metabolism gene	SARNP	LSM3	0.830894117	2.71E-13
DLBC	Cell metabolism gene	SARNP	POLR2I	0.832525146	2.21E-13
DLBC	Cell metabolism gene	SARNP	SNRPD3	0.837124235	1.23E-13
DLBC	Cell metabolism gene	SARNP	POLR2F	0.838407388	1.04E-13
DLBC	Cell metabolism gene	SARNP	PSMB3	0.852029655	1.60E-14
DLBC	Cell metabolism gene	SARNP	PSMD13	0.857140341	7.56E-15
DLBC	Cell metabolism gene	SARNP	DTYMK	0.857547495	7.11E-15
DLBC	Cell metabolism gene	SARNP	SNRPB	0.863482726	2.86E-15
DLBC	Cell metabolism gene	SARNP	SNRPD2	0.865221611	2.17E-15
DLBC	Epifactor	SARNP	PPP4C	0.835092606	1.60E-13
DLBC	IUPHAR	SARNP	BIRC5	0.849913205	2.17E-14
DLBC	TF	SARNP	NME2	0.818850377	1.15E-12
DLBC	TF	SARNP	PIN1	0.822618517	7.41E-13
DLBC	TSG	SARNP	PHB	0.804655434	5.54E-12
DLBC	TSG	SARNP	PIN1	0.822618517	7.41E-13
DLBC	TSG	SARNP	GADD45GIP1	0.82477796	5.73E-13
DLBC	TSG	SARNP	PARK7	0.831735198	2.44E-13
GBM	Cell metabolism gene	SARNP	LSM1	0.801899956	7.13E-40
GBM	Cell metabolism gene	SARNP	SNRPG	0.804450326	2.66E-40
GBM	Cell metabolism gene	SARNP	PSMD14	0.808506889	5.40E-41
GBM	Cell metabolism gene	SARNP	PFDN5	0.813957613	5.95E-42
GBM	Epifactor	SARNP	UBE2N	0.806113791	1.39E-40
GBM	Epifactor	SARNP	DPY30	0.82368701	9.64E-44
GBM	IUPHAR	SARNP	PSMD14	0.808506889	5.40E-41
KICH	Cell metabolism gene	SARNP	SNRPD2	0.802994774	1.03E-21
KIRP	Cell metabolism gene	SARNP	SNRPF	0.829377605	3.72E-83
KIRP	Cell metabolism gene	SARNP	PFDN5	0.833623693	9.40E-85
PRAD	Cell metabolism gene	SARNP	PSMB3	0.811612429	4.98E-130
PRAD	Cell metabolism gene	SARNP	PSMC1	0.815295874	3.86E-132
PRAD	Cell metabolism gene	SARNP	SNRPD2	0.817016869	3.84E-133
PRAD	Cell metabolism gene	SARNP	PFDN5	0.833923496	1.39E-143
PRAD	Epifactor	SARNP	RBX1	0.808082417	4.74E-128
THCA	Cell metabolism gene	SARNP	PSMB3	0.801469481	2.26E-129
THCA	Cell metabolism gene	SARNP	PSMB1	0.83694828	2.41E-151
THCA	Cell metabolism gene	SARNP	SNRPD1	0.845944476	9.05E-158
THCA	Cell metabolism gene	SARNP	SNRPD2	0.856426916	8.51E-166
THCA	Epifactor	SARNP	C17orf49	0.807234951	1.25E-132
THCA	IUPHAR	SARNP	PSMB1	0.83694828	2.41E-151
THYM	Cell metabolism gene	SARNP	SNRPG	0.801223431	1.55E-28
THYM	Cell metabolism gene	SARNP	PSMA6	0.802980528	9.66E-29
THYM	Cell metabolism gene	SARNP	FPGS	0.803343283	8.75E-29
THYM	Cell metabolism gene	SARNP	SNRPE	0.803682498	7.97E-29
THYM	Cell metabolism gene	SARNP	MTMR14	0.805281418	5.14E-29
THYM	Cell metabolism gene	SARNP	SLC25A11	0.8055658	4.75E-29
THYM	Cell metabolism gene	SARNP	PSME1	0.80641979	3.75E-29
THYM	Cell metabolism gene	SARNP	OAZ1	0.806480256	3.69E-29
THYM	Cell metabolism gene	SARNP	PSMB10	0.807805904	2.55E-29
THYM	Cell metabolism gene	SARNP	GUK1	0.809342302	1.65E-29
THYM	Cell metabolism gene	SARNP	POLR2H	0.809923858	1.40E-29
THYM	Cell metabolism gene	SARNP	TIMM22	0.813140593	5.58E-30
THYM	Cell metabolism gene	SARNP	PFDN5	0.815793857	2.57E-30
THYM	Cell metabolism gene	SARNP	UROD	0.81827415	1.23E-30
THYM	Cell metabolism gene	SARNP	PFDN6	0.819443525	8.70E-31
THYM	Cell metabolism gene	SARNP	PHKG2	0.821355625	4.88E-31
THYM	Cell metabolism gene	SARNP	FAU	0.826396519	1.03E-31
THYM	Cell metabolism gene	SARNP	SLC27A5	0.827728934	6.75E-32
THYM	Cell metabolism gene	SARNP	SEC61G	0.829233018	4.18E-32
THYM	Cell metabolism gene	SARNP	TIMM13	0.82954166	3.79E-32
THYM	Cell metabolism gene	SARNP	APRT	0.830822271	2.51E-32
THYM	Cell metabolism gene	SARNP	SEC13	0.834829525	6.76E-33
THYM	Cell metabolism gene	SARNP	GALK1	0.835815385	4.87E-33
THYM	Cell metabolism gene	SARNP	LSM5	0.836702038	3.62E-33
THYM	Cell metabolism gene	SARNP	SNRPD3	0.838127954	2.24E-33
THYM	Cell metabolism gene	SARNP	EXOSC1	0.83844147	2.01E-33
THYM	Cell metabolism gene	SARNP	ACOT8	0.839712707	1.30E-33
THYM	Cell metabolism gene	SARNP	PSMB1	0.84112992	7.99E-34
THYM	Cell metabolism gene	SARNP	NUDT5	0.842973768	4.20E-34
THYM	Cell metabolism gene	SARNP	TXN	0.84392047	3.01E-34
THYM	Cell metabolism gene	SARNP	DTYMK	0.859902185	7.60E-37
THYM	Cell metabolism gene	SARNP	SNRPB	0.865523953	7.76E-38
THYM	Cell metabolism gene	SARNP	ZNRD1	0.866877851	4.41E-38
THYM	Cell metabolism gene	SARNP	POLR3K	0.868569646	2.16E-38
THYM	Cell metabolism gene	SARNP	PSMA5	0.870231339	1.06E-38
THYM	Cell metabolism gene	SARNP	PSMB3	0.87220676	4.48E-39
THYM	Cell metabolism gene	SARNP	PSMB6	0.87256726	3.83E-39
THYM	Cell metabolism gene	SARNP	TIMM8B	0.873403874	2.64E-39
THYM	Cell metabolism gene	SARNP	AAAS	0.873485679	2.55E-39
THYM	Cell metabolism gene	SARNP	SEC61B	0.87380341	2.21E-39
THYM	Cell metabolism gene	SARNP	PSMB7	0.874528774	1.60E-39
THYM	Cell metabolism gene	SARNP	SNRPD2	0.875625309	9.79E-40
THYM	Cell metabolism gene	SARNP	LSM3	0.879800655	1.44E-40
THYM	Cell metabolism gene	SARNP	DGUOK	0.885887563	7.66E-42
THYM	Cell metabolism gene	SARNP	PSMA4	0.887337788	3.72E-42
THYM	Cell metabolism gene	SARNP	SNRPF	0.895119469	6.44E-44
THYM	Cell metabolism gene	SARNP	PSMD9	0.897465428	1.78E-44
THYM	Cell metabolism gene	SARNP	LSM2	0.899244311	6.57E-45
THYM	Cell metabolism gene	SARNP	LSM4	0.900264741	3.68E-45
THYM	Cell metabolism gene	SARNP	SNRPD1	0.903277166	6.41E-46
THYM	Cell metabolism gene	SARNP	PSMC3	0.916572661	1.34E-49
THYM	Cell metabolism gene	SARNP	PSMD13	0.930315736	4.15E-54
THYM	CGC	SARNP	TFPT	0.848500914	5.82E-35
THYM	CGC	SARNP	U2AF1	0.84881611	5.19E-35
THYM	CGC	SARNP	BAX	0.849424655	4.15E-35
THYM	CGC	SARNP	SDHAF2	0.858518516	1.31E-36
THYM	Epifactor	SARNP	MAZ	0.808152189	2.31E-29
THYM	Epifactor	SARNP	PRPF31	0.811297994	9.47E-30
THYM	Epifactor	SARNP	BRMS1	0.827013166	8.46E-32
THYM	Epifactor	SARNP	SIRT6	0.838093159	2.26E-33
THYM	Epifactor	SARNP	EXOSC1	0.83844147	2.01E-33
THYM	Epifactor	SARNP	RBX1	0.83888323	1.73E-33
THYM	Epifactor	SARNP	TFPT	0.848500914	5.82E-35
THYM	Epifactor	SARNP	TRIM28	0.849750098	3.68E-35
THYM	Epifactor	SARNP	TAF10	0.850776386	2.52E-35
THYM	Epifactor	SARNP	PPM1G	0.853230958	1.01E-35
THYM	Epifactor	SARNP	SS18L2	0.858204081	1.49E-36
THYM	Epifactor	SARNP	INO80C	0.859283421	9.72E-37
THYM	Epifactor	SARNP	C17orf49	0.872417441	4.09E-39
THYM	Epifactor	SARNP	RUVBL2	0.874430072	1.67E-39
THYM	Epifactor	SARNP	PPP4C	0.900970811	2.46E-45
THYM	Epifactor	SARNP	MCRS1	0.909811166	1.18E-47
THYM	IUPHAR	SARNP	TWF2	0.800455485	1.91E-28
THYM	IUPHAR	SARNP	MFSD2B	0.805289136	5.13E-29
THYM	IUPHAR	SARNP	SLC25A11	0.8055658	4.75E-29
THYM	IUPHAR	SARNP	MPDU1	0.809635245	1.52E-29
THYM	IUPHAR	SARNP	DYRK4	0.821106762	5.26E-31
THYM	IUPHAR	SARNP	PHKG2	0.821355625	4.88E-31
THYM	IUPHAR	SARNP	SLC27A5	0.827728934	6.75E-32
THYM	IUPHAR	SARNP	SIRT6	0.838093159	2.26E-33
THYM	IUPHAR	SARNP	PSMB1	0.84112992	7.99E-34
THYM	IUPHAR	SARNP	TRIM28	0.849750098	3.68E-35
THYM	IUPHAR	SARNP	PPIA	0.851884482	1.67E-35
THYM	IUPHAR	SARNP	CSNK2B	0.869696387	1.33E-38
THYM	IUPHAR	SARNP	PSMB6	0.87256726	3.83E-39
THYM	Kinase	SARNP	DYRK4	0.821106762	5.26E-31
THYM	Kinase	SARNP	PHKG2	0.821355625	4.88E-31
THYM	Kinase	SARNP	TRIM28	0.849750098	3.68E-35
THYM	TF	SARNP	NAIF1	0.80033945	1.97E-28
THYM	TF	SARNP	ZNF787	0.805072353	5.44E-29
THYM	TF	SARNP	MAZ	0.808152189	2.31E-29
THYM	TF	SARNP	THAP3	0.813572222	4.92E-30
THYM	TF	SARNP	GTF3A	0.815629209	2.70E-30
THYM	TF	SARNP	ZNF668	0.822114423	3.87E-31
THYM	TF	SARNP	ZNF653	0.822943408	3.00E-31
THYM	TF	SARNP	DRAP1	0.826220056	1.09E-31
THYM	TF	SARNP	PIN1	0.834032754	8.80E-33
THYM	TF	SARNP	ZNF444	0.850648154	2.64E-35
THYM	TF	SARNP	ZNF428	0.853124005	1.05E-35
THYM	TF	SARNP	DNTTIP1	0.870382935	9.91E-39
THYM	TF	SARNP	THYN1	0.882525412	3.94E-41
THYM	TSG	SARNP	FBXO25	0.806277293	3.90E-29
THYM	TSG	SARNP	PARK7	0.817273967	1.66E-30
THYM	TSG	SARNP	GNB2L1	0.819640112	8.20E-31
THYM	TSG	SARNP	ZNF668	0.822114423	3.87E-31
THYM	TSG	SARNP	BRMS1	0.827013166	8.46E-32
THYM	TSG	SARNP	DIABLO	0.831314375	2.14E-32
THYM	TSG	SARNP	PIN1	0.834032754	8.80E-33
THYM	TSG	SARNP	TSSC4	0.835481109	5.44E-33
THYM	TSG	SARNP	SIRT6	0.838093159	2.26E-33
THYM	TSG	SARNP	BAX	0.849424655	4.15E-35
THYM	TSG	SARNP	AIP	0.856584092	2.79E-36
THYM	TSG	SARNP	HTRA2	0.860548837	5.88E-37
THYM	TSG	SARNP	PFN1	0.888921928	1.67E-42
UCS	Cell metabolism gene	SARNP	SNRPG	0.801223431	1.55E-28
UCS	Cell metabolism gene	SARNP	PSMA6	0.802980528	9.66E-29
UCS	Cell metabolism gene	SARNP	FPGS	0.803343283	8.75E-29
UCS	Cell metabolism gene	SARNP	SNRPE	0.803682498	7.97E-29
UCS	Cell metabolism gene	SARNP	MTMR14	0.805281418	5.14E-29
UCS	Cell metabolism gene	SARNP	SLC25A11	0.8055658	4.75E-29
UCS	Cell metabolism gene	SARNP	PSME1	0.80641979	3.75E-29
UCS	Cell metabolism gene	SARNP	OAZ1	0.806480256	3.69E-29
UCS	Cell metabolism gene	SARNP	PSMB10	0.807805904	2.55E-29
UCS	Cell metabolism gene	SARNP	GUK1	0.809342302	1.65E-29
UCS	Cell metabolism gene	SARNP	POLR2H	0.809923858	1.40E-29
UCS	Cell metabolism gene	SARNP	TIMM22	0.813140593	5.58E-30
UCS	Cell metabolism gene	SARNP	PFDN5	0.815793857	2.57E-30
UCS	Cell metabolism gene	SARNP	UROD	0.81827415	1.23E-30
UCS	Cell metabolism gene	SARNP	PFDN6	0.819443525	8.70E-31
UCS	Cell metabolism gene	SARNP	PHKG2	0.821355625	4.88E-31
UCS	Cell metabolism gene	SARNP	FAU	0.826396519	1.03E-31
UCS	Cell metabolism gene	SARNP	SLC27A5	0.827728934	6.75E-32
UCS	Cell metabolism gene	SARNP	SEC61G	0.829233018	4.18E-32
UCS	Cell metabolism gene	SARNP	TIMM13	0.82954166	3.79E-32
UCS	Cell metabolism gene	SARNP	APRT	0.830822271	2.51E-32
UCS	Cell metabolism gene	SARNP	SEC13	0.834829525	6.76E-33
UCS	Cell metabolism gene	SARNP	GALK1	0.835815385	4.87E-33
UCS	Cell metabolism gene	SARNP	LSM5	0.836702038	3.62E-33
UCS	Cell metabolism gene	SARNP	SNRPD3	0.838127954	2.24E-33
UCS	Cell metabolism gene	SARNP	EXOSC1	0.83844147	2.01E-33
UCS	Cell metabolism gene	SARNP	ACOT8	0.839712707	1.30E-33
UCS	Cell metabolism gene	SARNP	PSMB1	0.84112992	7.99E-34
UCS	Cell metabolism gene	SARNP	NUDT5	0.842973768	4.20E-34
UCS	Cell metabolism gene	SARNP	TXN	0.84392047	3.01E-34
UCS	Cell metabolism gene	SARNP	DTYMK	0.859902185	7.60E-37
UCS	Cell metabolism gene	SARNP	SNRPB	0.865523953	7.76E-38
UCS	Cell metabolism gene	SARNP	ZNRD1	0.866877851	4.41E-38
UCS	Cell metabolism gene	SARNP	POLR3K	0.868569646	2.16E-38
UCS	Cell metabolism gene	SARNP	PSMA5	0.870231339	1.06E-38
UCS	Cell metabolism gene	SARNP	PSMB3	0.87220676	4.48E-39
UCS	Cell metabolism gene	SARNP	PSMB6	0.87256726	3.83E-39
UCS	Cell metabolism gene	SARNP	TIMM8B	0.873403874	2.64E-39
UCS	Cell metabolism gene	SARNP	AAAS	0.873485679	2.55E-39
UCS	Cell metabolism gene	SARNP	SEC61B	0.87380341	2.21E-39
UCS	Cell metabolism gene	SARNP	PSMB7	0.874528774	1.60E-39
UCS	Cell metabolism gene	SARNP	SNRPD2	0.875625309	9.79E-40
UCS	Cell metabolism gene	SARNP	LSM3	0.879800655	1.44E-40
UCS	Cell metabolism gene	SARNP	DGUOK	0.885887563	7.66E-42
UCS	Cell metabolism gene	SARNP	PSMA4	0.887337788	3.72E-42
UCS	Cell metabolism gene	SARNP	SNRPF	0.895119469	6.44E-44
UCS	Cell metabolism gene	SARNP	PSMD9	0.897465428	1.78E-44
UCS	Cell metabolism gene	SARNP	LSM2	0.899244311	6.57E-45
UCS	Cell metabolism gene	SARNP	LSM4	0.900264741	3.68E-45
UCS	Cell metabolism gene	SARNP	SNRPD1	0.903277166	6.41E-46
UCS	Cell metabolism gene	SARNP	PSMC3	0.916572661	1.34E-49
UCS	Cell metabolism gene	SARNP	PSMD13	0.930315736	4.15E-54
UCS	CGC	SARNP	TFPT	0.848500914	5.82E-35
UCS	CGC	SARNP	U2AF1	0.84881611	5.19E-35
UCS	CGC	SARNP	BAX	0.849424655	4.15E-35
UCS	CGC	SARNP	SDHAF2	0.858518516	1.31E-36
UCS	Epifactor	SARNP	MAZ	0.808152189	2.31E-29
UCS	Epifactor	SARNP	PRPF31	0.811297994	9.47E-30
UCS	Epifactor	SARNP	BRMS1	0.827013166	8.46E-32
UCS	Epifactor	SARNP	SIRT6	0.838093159	2.26E-33
UCS	Epifactor	SARNP	EXOSC1	0.83844147	2.01E-33
UCS	Epifactor	SARNP	RBX1	0.83888323	1.73E-33
UCS	Epifactor	SARNP	TFPT	0.848500914	5.82E-35
UCS	Epifactor	SARNP	TRIM28	0.849750098	3.68E-35
UCS	Epifactor	SARNP	TAF10	0.850776386	2.52E-35
UCS	Epifactor	SARNP	PPM1G	0.853230958	1.01E-35
UCS	Epifactor	SARNP	SS18L2	0.858204081	1.49E-36
UCS	Epifactor	SARNP	INO80C	0.859283421	9.72E-37
UCS	Epifactor	SARNP	C17orf49	0.872417441	4.09E-39
UCS	Epifactor	SARNP	RUVBL2	0.874430072	1.67E-39
UCS	Epifactor	SARNP	PPP4C	0.900970811	2.46E-45
UCS	Epifactor	SARNP	MCRS1	0.909811166	1.18E-47
UCS	IUPHAR	SARNP	TWF2	0.800455485	1.91E-28
UCS	IUPHAR	SARNP	MFSD2B	0.805289136	5.13E-29
UCS	IUPHAR	SARNP	SLC25A11	0.8055658	4.75E-29
UCS	IUPHAR	SARNP	MPDU1	0.809635245	1.52E-29
UCS	IUPHAR	SARNP	DYRK4	0.821106762	5.26E-31
UCS	IUPHAR	SARNP	PHKG2	0.821355625	4.88E-31
UCS	IUPHAR	SARNP	SLC27A5	0.827728934	6.75E-32
UCS	IUPHAR	SARNP	SIRT6	0.838093159	2.26E-33
UCS	IUPHAR	SARNP	PSMB1	0.84112992	7.99E-34
UCS	IUPHAR	SARNP	TRIM28	0.849750098	3.68E-35
UCS	IUPHAR	SARNP	PPIA	0.851884482	1.67E-35
UCS	IUPHAR	SARNP	CSNK2B	0.869696387	1.33E-38
UCS	IUPHAR	SARNP	PSMB6	0.87256726	3.83E-39
UCS	Kinase	SARNP	DYRK4	0.821106762	5.26E-31
UCS	Kinase	SARNP	PHKG2	0.821355625	4.88E-31
UCS	Kinase	SARNP	TRIM28	0.849750098	3.68E-35
UCS	TF	SARNP	NAIF1	0.80033945	1.97E-28
UCS	TF	SARNP	ZNF787	0.805072353	5.44E-29
UCS	TF	SARNP	MAZ	0.808152189	2.31E-29
UCS	TF	SARNP	THAP3	0.813572222	4.92E-30
UCS	TF	SARNP	GTF3A	0.815629209	2.70E-30
UCS	TF	SARNP	ZNF668	0.822114423	3.87E-31
UCS	TF	SARNP	ZNF653	0.822943408	3.00E-31
UCS	TF	SARNP	DRAP1	0.826220056	1.09E-31
UCS	TF	SARNP	PIN1	0.834032754	8.80E-33
UCS	TF	SARNP	ZNF444	0.850648154	2.64E-35
UCS	TF	SARNP	ZNF428	0.853124005	1.05E-35
UCS	TF	SARNP	DNTTIP1	0.870382935	9.91E-39
UCS	TF	SARNP	THYN1	0.882525412	3.94E-41
UCS	TSG	SARNP	FBXO25	0.806277293	3.90E-29
UCS	TSG	SARNP	PARK7	0.817273967	1.66E-30
UCS	TSG	SARNP	GNB2L1	0.819640112	8.20E-31
UCS	TSG	SARNP	ZNF668	0.822114423	3.87E-31
UCS	TSG	SARNP	BRMS1	0.827013166	8.46E-32
UCS	TSG	SARNP	DIABLO	0.831314375	2.14E-32
UCS	TSG	SARNP	PIN1	0.834032754	8.80E-33
UCS	TSG	SARNP	TSSC4	0.835481109	5.44E-33
UCS	TSG	SARNP	SIRT6	0.838093159	2.26E-33
UCS	TSG	SARNP	BAX	0.849424655	4.15E-35
UCS	TSG	SARNP	AIP	0.856584092	2.79E-36
UCS	TSG	SARNP	HTRA2	0.860548837	5.88E-37
UCS	TSG	SARNP	PFN1	0.888921928	1.67E-42
UVM	TF	SARNP	ZNF140	0.803448715	3.02E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	SARNP	POLDIP3	-1.36570096217917	0.000163098851560177
LUAD	SARNP	THOC6	-1.90262048273771	0.000168034255737158
LUAD	SARNP	THOC1	-1.06832301661838	0.000221536863639365
ESCA	SARNP	THOC6	-1.34410621278202	0.0009765625
COAD	SARNP	THOC5	-2.56175519219209	0.00468936562538148
CHOL	SARNP	THOC2	-2.40493946242101	0.01953125
LIHC	SARNP	THOC6	-1.30431783981178	0.0227162265784831
ESCA	SARNP	THOC2	1.32339478260186	0.0244140625
KICH	SARNP	THOC6	-1.97403024254731	0.0341737866401672
BRCA	SARNP	THOC1	1.10115715089473	0.0351942828492497
UCEC	SARNP	THOC7	1.82323719111749	0.046875
THCA	SARNP	THOC5	-3.65510543042315	1.669702536531e-09
BRCA	SARNP	THOC6	-2.05474598873329	3.04803888661931e-16
KIRC	SARNP	THOC5	-1.91220971053405	3.94691334869101e-05
BRCA	SARNP	THOC2	1.19658609838291	4.13174318927989e-05
STAD	SARNP	THOC6	-2.52142458864358	5.24520874023438e-06
KIRC	SARNP	THOC6	-1.65810184458569	7.97099448083997e-11
THCA	SARNP	THOC6	-3.08710759510512	9.10957289155119e-07
LIHC	SARNP	THOC2	-1.08253591644136	9.8153527952559e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with SARNP

DDX39A, FUS, CSNK2B, CDK2, VHL, MRPL14, MRRF, VDAC3, NABP2, SRCAP, TIMM44, TAGLN, ZC3H11A, UBL4A, SBDS, MPLKIP, TBL2, MRPS31, STX7, SRPRB, THY1, SRRM2, RBMS1, SNRPC, TPX2, ACAA1, UBE2I, UBE4B, TIAL1, HSPD1, FN1, PLCG1, RIC8A, CSTB, DPP7, YARS, WDR61, ESR1, DNAJC14, EWSR1, THOC1, MPP1, PFKFB2, THOC2, THOC7, LIMK1, U2AF2, CCDC9, ZC3H14, FYTTD1, KBTBD7, ACIN1, CHTOP, C17orf85, RNPS1, PPIG, POLDIP3, MAGOH, PPP2R2D, PNN, CRIP2, THOC5, CPVL, EIF4A3, WDR45B, COPZ1, SUB1, CHORDC1, DIS3, SEPT7, PRCC, CDK5, SH3GLB1, DRG1, SCYL2, PDHA1, TNIP2, CHD3, DAPK1, HERC2, RECQL4, HIST1H3A, ATG16L1, XRCC6, DDX39B, FANCD2, HMMR, HTR1A, UBR5, CIT, BRD4, NUPR1, RBM39, SMYD1, ADSS, CAPNS1, HIST1H2BG, RPS6, TERF2IP, ZNF330, DDAH2, YTHDF1, EXOSC8, Ddx39, ORF7a, ORF7b, MAP1LC3B, SIRT6, BRD3,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
SARNP	LGG	chr12	56197482	56197482	G	A	Missense_Mutation	p.R23C	3
SARNP	BRCA	chr12	56211512	56211512	C	A	RNA	NULL	2
SARNP	UCEC	chr12	56197481	56197481	C	A	Missense_Mutation	p.R23L	2
SARNP	STAD	chr12	56211464	56211464	G	A	Missense_Mutation	p.L8F	2
SARNP	TGCT	chr12	56154395	56154395	C	T	Silent		2
SARNP	UCEC	chr12	56151231	56151231	A	G	RNA	NULL	2
SARNP	ESCA	chr12	56184369	56184369	T	A	Silent		2
SARNP	UCEC	chr12	56182893	56182893	C	A	Missense_Mutation	p.R156I	2
SARNP	UCEC	chr12	56188601	56188601	G	A	Missense_Mutation	p.R123W	2
SARNP	UCEC	chr12	56188666	56188666	T	A	Splice_Site	e6-2	2
SARNP	UCEC	chr12	56189808	56189808	C	T	Splice_Site	e5+1	2
SARNP	UCEC	chr12	56194405	56194405	T	G	Missense_Mutation	p.E64D	2
SARNP	BLCA	chr12	56194387	56194387	G	C	Silent		1
SARNP	SKCM	chr12	56211530	56211530	C	A	Translation_Start_Site		1
SARNP	BLCA	chr12	56188172	56188172	C	A	Splice_Site		1
SARNP	SKCM	chr12	56188603	56188603	G	A	Missense_Mutation	p.A62V	1
SARNP	BRCA	chr12	56151291	56151291	T	C	RNA	NULL	1
SARNP	LIHC	chr12	56182898	56182898	A	G	Silent		1
SARNP	BLCA	chr12	56188160	56188160	G	C	Missense_Mutation		1
SARNP	CESC	chr12	56182900	56182900	C	T	Missense_Mutation		1
SARNP	LIHC	chr12	56197433	56197433	T	C	Missense_Mutation		1
SARNP	BLCA	chr12	56189844	56189844	C	T	Missense_Mutation		1
SARNP	COAD	chr12	56188597	56188597	G	A	Missense_Mutation	p.A124V	1
SARNP	LIHC	chr12	56154345	56154345	T	C	Missense_Mutation	p.E194G	1
SARNP	BLCA	chr12	56188642	56188642	C	T	Missense_Mutation		1
SARNP	TGCT	chr12	56154395	56154395	C	T	Silent	p.R177R	1
SARNP	COAD	chr12	56197484	56197484	G	A	Missense_Mutation	p.A22V	1
SARNP	LIHC	chr12	56197508	56197508	G	A	Missense_Mutation	p.A14V	1
SARNP	BLCA	chr12	56188173	56188173	T	C	Splice_Site		1
SARNP	LUAD	chr12	56211462	56211462	G	A	Silent	p.L8L	1
SARNP	BLCA	chr12	56194392	56194392	C	T	Missense_Mutation		1
SARNP	ESCA	chr12	56154405	56154405	A	G	Missense_Mutation	p.L174P	1
SARNP	LUAD	chr12	56188646	56188646	C	T	Missense_Mutation	p.E48K	1
SARNP	BLCA	chr12	56194413	56194413	C	G	Missense_Mutation		1
SARNP	ESCA	chr12	56184369	56184369	T	A	Silent	p.S138S	1
SARNP	READ	chr12	56194674	56194674	C	A	Missense_Mutation	p.E49D	1
SARNP	BLCA	chr12	56188642	56188642	C	T	Missense_Mutation	p.R49Q	1
SARNP	HNSC	chr12	56182870	56182870	T	C	Missense_Mutation		1
SARNP	SARC	chr12	56197444	56197444	G	T	Silent		1
SARNP	BLCA	chr12	56184362	56184362	T	C	Missense_Mutation	p.N81D	1
SARNP	KIRC	chr12	56154343	56154343	C	G	Missense_Mutation	p.D195H	1
SARNP	SKCM	chr12	56182877	56182877	G	A	Silent	p.V161V	1
SARNP	BLCA	chr12	56194392	56194392	C	T	Missense_Mutation	p.E9K	1
SARNP	KIRP	chr12	56182870	56182870	T	C	Missense_Mutation	p.I164V	1

Copy number variation (CNV) of SARNP
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across SARNP
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102999	N/A	AI821510	CHRM1	chr11	62676153	-	SARNP	chr12	56193377	-
102999	BRCA	TCGA-BH-A6R8-01A	CPSF4	chr7	99040869	-	SARNP	chr12	56194367	-
102999	PRAD	TCGA-QU-A6IO-01A	CPSF4	chr7	99040816	-	SARNP	chr12	56194410	-
102999	N/A	BM972619	CPSF4	chr7	99040924	+	SARNP	chr12	56151054	+
102999	SKCM	TCGA-GN-A26D-06A	GABRA3	chrX	151393235	-	SARNP	chr12	56146624	-
102999	STAD	TCGA-BR-4257	GNS	chr12	65152864	-	SARNP	chr12	56154424	-
102999	SARC	TCGA-DX-A2J1-01A	HMGA2	chr12	66345195	+	SARNP	chr12	56146624	-
102999	.	.	KMT2A	chr11	118353210	+	SARNP	chr12	56197512	-
102999	STAD	TCGA-HU-A4GJ-01A	LMBR1	chr7	156469080	-	SARNP	chr12	56197512	-
102999	SARC	TCGA-DX-A2J1-01A	NR4A1	chr12	52437695	+	SARNP	chr12	56151337	-
102999	SARC	TCGA-DX-A2J1	ORMDL2	chr12	56211896	+	SARNP	chr12	56151337	-
102999	PRAD	TCGA-HC-8264	PKP2	chr12	32955337	-	SARNP	chr12	56151337	-
102999	PRAD	TCGA-HC-8264-01B	PKP2	chr12	32955337	-	SARNP	chr12	56154424	-
102999	BRCA	TCGA-A8-A0A4-01A	RILPL1	chr12	123968727	-	SARNP	chr12	56151337	-
102999	PRAD	TCGA-J4-A67S	RNF41	chr12	56615543	-	SARNP	chr12	56146624	-
102999	PRAD	TCGA-J4-A67S	RNF41	chr12	56615686	-	SARNP	chr12	56146624	-
102999	PRAD	TCGA-J4-A67S	RNF41	chr12	56615687	-	SARNP	chr12	56146624	-
102999	PRAD	TCGA-J4-A67S-01A	RNF41	chr12	56615544	-	SARNP	chr12	56146624	-
101898	STAD	TCGA-BR-8286	SARNP	chr12	56182858	-	ATF1	chr12	51189691	+
92021	N/A	BC007099	SARNP	chr12	56151058	-	ATP5J2-PTCD1	chr7	99043163	-
92021	N/A	FN177874	SARNP	chr12	56188589	-	ATP5J2-PTCD1	chr7	99040800	-
79206	BRCA	TCGA-3C-AALJ-01A	SARNP	chr12	56182859	-	BLOC1S1	chr12	56112875	+
103187	N/A	BE843441	SARNP	chr12	56211285	+	C7orf73	chr7	135359100	-
99245	OV	TCGA-29-1697-01A	SARNP	chr12	56188591	-	CS	chr12	56676775	-
103035	N/A	AI393207	SARNP	chr12	56127968	-	HDLBP	chr2	242240440	-
96769	OV	TCGA-09-1666	SARNP	chr12	56211449	-	KCNN4	chr19	44280788	-
96769	OV	TCGA-09-1666-01A	SARNP	chr12	56209671	-	KCNN4	chr19	44280788	-
96769	OV	TCGA-09-1666-01A	SARNP	chr12	56211450	-	KCNN4	chr19	44280788	-
101006	UCEC	TCGA-AJ-A3NF-01A	SARNP	chr12	56189809	-	KRT8	chr12	53298811	-
79206	SARC	TCGA-HB-A43Z-01A	SARNP	chr12	56211450	-	MMP19	chr12	56236222	-
95310	SARC	TCGA-DX-A2IZ-01A	SARNP	chr12	56188143	-	NT5DC3	chr12	104200707	-
79206	BLCA	TCGA-2F-A9KP	SARNP	chr12	56211449	-	PAN2	chr12	56722425	-
79206	BLCA	TCGA-2F-A9KP-01A	SARNP	chr12	56211450	-	PAN2	chr12	56722425	-
93143	OV	TCGA-30-1714	SARNP	chr12	56211449	-	PTGES3	chr12	57064148	-
93143	OV	TCGA-30-1714	SARNP	chr12	56211449	-	PTGES3	chr12	57065631	-
93143	OV	TCGA-30-1714-01A	SARNP	chr12	56211450	-	PTGES3	chr12	57065631	-
88008	LUAD	TCGA-44-7669-01A	SARNP	chr12	56182859	-	PTMS	chr12	6878769	+
95099	OV	TCGA-36-1578	SARNP	chr12	56182858	-	SMARCC2	chr12	56571877	-
98143	STAD	TCGA-BR-8080-01A	SARNP	chr12	56211450	-	STAT6	chr12	57502082	-
97458	LUSC	TCGA-NC-A5HQ-01A	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
79206	ESCA	TCGA-LN-A4A3	SARNP	chr12	56188143	-	WIBG	chr12	56297264	-
86327	N/A	FN167689	SARNP	chr12	56146372	-	ZNF474	chr5	121471851	+
102999	N/A	NM_001136258	SGMS2	chr4	108836203	+	SARNP	chr12	56061458	+
102999	ACC	TCGA-OR-A5KT-01A	SLC16A7	chr12	59990017	+	SARNP	chr12	56154424	-
102999	N/A	BF809919	TOMM20	chr1	235273945	-	SARNP	chr12	56194347	+
102999	Non-Cancer	TCGA-HC-7819-11A	WBP11	chr12	14956285	-	SARNP	chr12	56154424	-
102999	OV	TCGA-29-1698-01A	WIBG	chr12	56308060	-	SARNP	chr12	56184376	-
102999	OV	TCGA-29-1698-01A	WIBG	chr12	56320860	-	SARNP	chr12	56184376	-
102999	OV	TCGA-29-1698-01A	WIBG	chr12	56321509	-	SARNP	chr12	56184376	-
102999	PRAD	TCGA-ZG-A9L5	ZNF528	chr19	52909286	+	SARNP	chr12	56197512	-
102999	SARC	TCGA-DX-A6BE-01A	ZNF562	chr19	9785691	-	SARNP	chr12	56146624	-
102999	PRAD	TCGA-ZG-A9L5-01A	ZNF761	chr19	53952892	+	SARNP	chr12	56197512	-
103002	PRAD	TCGA-ZG-A9L5	ZNF813	chr19	53990012	+	SARNP	chr12	56197512	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	SARNP	0.0202880310593061	0.57
ACC	SARNP	0.0415317898388475	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	SARNP	0.0362804110830447	1
GBM	SARNP	0.0443212726671179	1
THYM	SARNP	0.0418766150489048	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source