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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NCK2 (NCBI Gene ID:8440)

Gene Summary

Gene Summary

Gene Information	Gene Name: NCK2
	Gene ID: 8440
	Gene Symbol	NCK2
	Gene ID	8440
	Gene Name	NCK adaptor protein 2
	Synonyms	GRB4\|NCKbeta
	Cytomap	2q12.2
	Type of Gene	protein-coding
	Description	cytoplasmic protein NCK2SH2/SH3 adaptor protein NCK-betagrowth factor receptor-bound protein 4noncatalytic region of tyrosine kinase, beta
	Modification date	20200327
	UniProtAcc	O43639

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NCK2	GO:0033137	negative regulation of peptidyl-serine phosphorylation	16835242
Hgene	NCK2	GO:0045944	positive regulation of transcription by RNA polymerase II	10026169
Hgene	NCK2	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	16835242

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
NCK2	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'NCK2[title] AND translation [title] AND human.'

Gene	Title	PMID
NCK2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000233154	106471503	106471745	5CDS-5UTR
ENST00000233154	106497783	106498505	Frame-shift
ENST00000393349	106497783	106498505	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
HNSC	NCK2	-1.04620070721258	0.000590976526609666
KICH	NCK2	1.48700943339852	0.00181567668914795

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	NCK2	0.062350553	0.020558003

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NCK2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	NCK2	B3GNT3	0.809566639	1.67E-11
CHOL	Cell metabolism gene	NCK2	TEAD4	0.818272042	6.69E-12
CHOL	Cell metabolism gene	NCK2	MTMR2	0.821446553	4.74E-12
CHOL	Cell metabolism gene	NCK2	PPAP2C	0.82187304	4.52E-12
CHOL	Cell metabolism gene	NCK2	AACS	0.822770308	4.09E-12
CHOL	Cell metabolism gene	NCK2	ITPR3	0.836402865	8.47E-13
CHOL	Cell metabolism gene	NCK2	CACNB3	0.839334638	5.92E-13
CHOL	Cell metabolism gene	NCK2	INPP5J	0.855582901	7.10E-14
CHOL	Cell metabolism gene	NCK2	PLCD3	0.862813989	2.54E-14
CHOL	CGC	NCK2	ERCC3	0.804025126	2.91E-11
CHOL	CGC	NCK2	ATP1A1	0.807939326	1.97E-11
CHOL	CGC	NCK2	ELF4	0.809862901	1.62E-11
CHOL	CGC	NCK2	CCDC6	0.815779105	8.73E-12
CHOL	CGC	NCK2	MACC1	0.820347407	5.34E-12
CHOL	CGC	NCK2	SMAD3	0.82144762	4.74E-12
CHOL	CGC	NCK2	SRC	0.843334813	3.59E-13
CHOL	Epifactor	NCK2	CHAF1B	0.80040163	4.15E-11
CHOL	Epifactor	NCK2	RAI1	0.808815375	1.80E-11
CHOL	Epifactor	NCK2	CBX1	0.810962124	1.44E-11
CHOL	Epifactor	NCK2	CHEK1	0.815613156	8.89E-12
CHOL	Epifactor	NCK2	HIST3H2A	0.829424388	1.93E-12
CHOL	Epifactor	NCK2	HDAC7	0.831683167	1.48E-12
CHOL	Epifactor	NCK2	PCGF2	0.84833293	1.89E-13
CHOL	Epifactor	NCK2	CTBP2	0.89851884	5.62E-17
CHOL	IUPHAR	NCK2	SLC4A3	0.802416133	3.41E-11
CHOL	IUPHAR	NCK2	ATP1A1	0.807939326	1.97E-11
CHOL	IUPHAR	NCK2	CHEK1	0.815613156	8.89E-12
CHOL	IUPHAR	NCK2	S100A11	0.819616644	5.78E-12
CHOL	IUPHAR	NCK2	BRSK1	0.823036506	3.98E-12
CHOL	IUPHAR	NCK2	ST14	0.826072533	2.83E-12
CHOL	IUPHAR	NCK2	HDAC7	0.831683167	1.48E-12
CHOL	IUPHAR	NCK2	ITPR3	0.836402865	8.47E-13
CHOL	IUPHAR	NCK2	SRC	0.843334813	3.59E-13
CHOL	IUPHAR	NCK2	LPAR2	0.846472535	2.40E-13
CHOL	IUPHAR	NCK2	SLC37A1	0.849136864	1.70E-13
CHOL	IUPHAR	NCK2	CDC42BPG	0.850213368	1.47E-13
CHOL	IUPHAR	NCK2	STK39	0.850896196	1.34E-13
CHOL	IUPHAR	NCK2	MMP14	0.851416386	1.25E-13
CHOL	IUPHAR	NCK2	ITGB4	0.853325201	9.67E-14
CHOL	IUPHAR	NCK2	INPP5J	0.855582901	7.10E-14
CHOL	IUPHAR	NCK2	GABBR1	0.86024432	3.68E-14
CHOL	IUPHAR	NCK2	PLCD3	0.862813989	2.54E-14
CHOL	IUPHAR	NCK2	DDR1	0.870433518	8.04E-15
CHOL	IUPHAR	NCK2	SFXN3	0.877914313	2.42E-15
CHOL	Kinase	NCK2	CHEK1	0.815613156	8.89E-12
CHOL	Kinase	NCK2	BRSK1	0.823036506	3.98E-12
CHOL	Kinase	NCK2	SRC	0.843334813	3.59E-13
CHOL	Kinase	NCK2	CDC42BPG	0.850213368	1.47E-13
CHOL	Kinase	NCK2	STK39	0.850896196	1.34E-13
CHOL	Kinase	NCK2	DDR1	0.870433518	8.04E-15
CHOL	TF	NCK2	ELF4	0.809862901	1.62E-11
CHOL	TF	NCK2	CREB5	0.817086147	7.60E-12
CHOL	TF	NCK2	TEAD4	0.818272042	6.69E-12
CHOL	TF	NCK2	SMAD3	0.82144762	4.74E-12
CHOL	TF	NCK2	FBXL19	0.825743503	2.94E-12
CHOL	TF	NCK2	OVOL2	0.841055202	4.78E-13
CHOL	TF	NCK2	PCGF2	0.84833293	1.89E-13
CHOL	TSG	NCK2	ABI2	0.811176689	1.41E-11
CHOL	TSG	NCK2	CHEK1	0.815613156	8.89E-12
CHOL	TSG	NCK2	TES	0.818832717	6.30E-12
CHOL	TSG	NCK2	S100A11	0.819616644	5.78E-12
CHOL	TSG	NCK2	BRSK1	0.823036506	3.98E-12
CHOL	TSG	NCK2	SPINT2	0.839459253	5.83E-13
CHOL	TSG	NCK2	RAB25	0.846962533	2.25E-13
CHOL	TSG	NCK2	PCGF2	0.84833293	1.89E-13

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	NCK2	EGFR	1.32757138391417	0.000102202753672845
HNSC	NCK2	EFNB2	1.33945028543449	0.000109012144321241
STAD	NCK2	EFNB1	2.32526184708489	0.000121572986245155
COAD	NCK2	ILK	-2.29465178781443	0.00032070279121399
THCA	NCK2	EFNB2	-1.62161447026231	0.000405886158765646
LIHC	NCK2	NPHS1	-1.04631683480058	0.00070993257333961
STAD	NCK2	WASL	-1.81042588602242	0.00143672106787562
STAD	NCK2	ILK	-3.54377290530959	0.00192895717918873
CHOL	NCK2	GIT1	-6.01208723881845	0.00390625
LUSC	NCK2	EFNB1	1.13625020246463	0.00457577784727754
LIHC	NCK2	EGFR	-1.2230538094017	0.00496795806084514
CHOL	NCK2	NPHS1	-4.25064888606967	0.0142661867014469
PRAD	NCK2	KDR	-1.58796255343738	0.0194951957597077
ESCA	NCK2	WASL	-1.76047279146432	0.0244140625
READ	NCK2	WASL	-8.07531071992977	0.03125
KIRP	NCK2	EGFR	1.14056399927375	0.0394268441013992
HNSC	NCK2	LIMS1	1.90219087459442	1.07480439055508e-05
LUAD	NCK2	EFNB2	-1.51745607512969	1.16091444027929e-06
BRCA	NCK2	NPHS1	-1.92014454328342	1.17868654242659e-09
BRCA	NCK2	KDR	-1.01112009429379	1.35259778392042e-14
THCA	NCK2	EFNB1	-1.83599341929798	1.79479101961734e-07
KIRC	NCK2	EFNB2	1.01920922443458	1.86865390189606e-06
PRAD	NCK2	PAK1	1.99443643932778	2.04165287904647e-06
PRAD	NCK2	ILK	-1.49342752513425	2.0788587191656e-08
KIRC	NCK2	EGFR	1.55836383937799	2.25998111659284e-12
THCA	NCK2	GIT1	-1.99083797314897	3.0868085248098e-08
KIRC	NCK2	LIMS1	1.2184317645304	3.5168676455393e-06
HNSC	NCK2	EFNB1	1.52101417251379	3.95402821595781e-10
COAD	NCK2	WASL	-2.04452450106745	4.17232513427735e-07
KICH	NCK2	LIMS1	2.44907381603712	4.54187393188476e-05
KIRC	NCK2	ILK	1.75052148174077	4.61148288257625e-10
KIRC	NCK2	NPHS1	-2.67100943365389	5.95530520218696e-10
THCA	NCK2	LIMS1	2.80966685326125	6.03921940186051e-06
PRAD	NCK2	EFNB1	1.9222304468589	6.08744261568541e-10
KIRC	NCK2	GIT1	-1.57679395608611	7.43306349049898e-12
LUAD	NCK2	KDR	-1.05756116228192	8.0748918934853e-08
KICH	NCK2	NPHS1	-3.91534965627019	8.34465026855468e-07
KIRP	NCK2	NPHS1	-3.15978603773708	8.84756445884705e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NCK2

ABI2, TRIP6, KIAA1217, NCKIPSD, SF3B4, CBLB, WBP11, CPSF6, FXR2, CPSF7, HNRNPK, EEF1G, EGFR, PDGFRB, DOK1, DOCK1, WIPF2, CD3E, PTK2, PAK1, PKN2, SOS1, NTRK2, LIMS1, ILK, Pdgfrb, IRS1, MASP1, KHDRBS1, BLNK, FASLG, ATN1, EFNB1, ABI1, AXIN1, DNM1, ERBB2, ERBB3, SRPK2, SRPK1, SYNPO, WAS, CBL, PSMD10, CHN1, DVL1, NR5A1, HOXC4, LCP2, MAGEA6, MEOX2, REL, TRIM27, TCF4, TNR, RASSF7, NCK2, SORBS2, EIF3H, WASL, ARHGAP32, SPRY2, DRAP1, ZBTB7B, ABI3, FAM53C, BCL11A, VARS2, HOMEZ, RBM26, FCRL2, VPS37B, CCDC33, EFHC2, LZTS2, LNX1, TRIM41, PRR20A, LRRIQ3, UBC, DYX1C1, NCK1, SH3PXD2B, ARAP1, NCKAP1, ABL2, GIT2, GIT1, RAPH1, BAIAP2, ASAP2, ASAP1, CYFIP2, CYFIP1, PRRC2A, TNK2, MAP4K4, MINK1, TNIK, PAK2, NHSL1, CASKIN2, PEAK1, ARHGEF7, ARHGEF6, WASF1, WASF2, WASF3, TTC28, PIK3AP1, SHB, WIPF1, KIAA1522, NHSL2, MLLT4, WIPF3, LZTR1, SEMA6A, FAM83H, BRK1, FAM217B, FYB, SORBS1, CEP170, CEP44, CEP19, TRIM15, FGFR1, CDH1, PTPN12, LRFN4, DOK2, CPNE5, YLPM1, SMARCB1, LAS17, CAF16, HNRNPL, TNIP2, EFS, PKD1, SKAP2, BCAR1, PRDM6, MNT, TXK, DLGAP4, FBXL19, C19orf26, KCTD17, SNW1, SCML2, ZC2HC1A, SF3A2, SHD, PBX4, HOXA1, CHN2, INTS2, KLHL24, ZC2HC1B, SRMS, FOSB, RBBP8NL, NUTM2F, ZNF341, BTG1, C4orf17, GAREM, CCDC120, FAM83A, KLHL35, FAM124A, MIA3, SPATA2L, HSF2BP, SPATC1L, DISC1, ANKRD55, MBD6, NFKBID, ZNF526, SF1, REEP4, NPAS2, USP32, SSH3, NET1, HOXD8, MYPOP, DTX3, GGN, ZBTB42, DEFB124, CUEDC1, PRR16, TMEM121, CIB1, ANKS1B, NELFA, FAM47A, CLEC17A, KIAA0408, INCA1, SYNGAP1, FAM109A, CIPC, KPRP, ZBTB12, PRR20B, ONECUT3, PRR20D, PRR20C, ZNF688, PRR20E, TCP10L, SCX, SOCS7, DAB1, ORF3a, RET, PTPRA, GAB1, KIT, MET, ERBB4, CXADR, GJA1, PFN1, PXN, TJP2, VASP, MAP4K1, CD209, ADIPOR2, ARHGAP39, MICAL1, NHS, KLC2, CDC45, TOP3B, IFITM3, N,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NCK2	LUAD	chr2	106498084	106498084	C	G	Missense_Mutation	p.S176C	5
NCK2	COAD	chr2	106498393	106498393	G	A	Missense_Mutation	p.R279H	4
NCK2	BLCA	chr2	106498397	106498397	C	T	Silent		4
NCK2	SARC	chr2	106498349	106498349	G	A	Silent	p.A264A	3
NCK2	BLCA	chr2	106498397	106498397	C	T	Silent	p.F280F	3
NCK2	KIRP	chr2	106498221	106498221	A	G	Missense_Mutation	p.M222V	3
NCK2	PAAD	chr2	106509467	106509467	G	A	Silent	p.A326A	3
NCK2	PAAD	chr2	106498449	106498449	G	A	Missense_Mutation	p.A298T	3
NCK2	PAAD	chr2	106471526	106471526	G	A	Missense_Mutation	p.E3K	3
NCK2	PRAD	chr2	106497794	106497794	G	A	Silent	p.K79K	3
NCK2	SKCM	chr2	106509458	106509458	C	T	Missense_Mutation	p.P83S	3
NCK2	BRCA	chr2	106471553	106471553	G	T	Missense_Mutation	p.D12Y	3
NCK2	ESCA	chr2	106471533	106471533	T	G	Missense_Mutation	p.V5G	3
NCK2	BRCA	chr2	106509512	106509512	C	T	Silent	p.V341	3
NCK2	UCEC	chr2	106509519	106509519	A	G	Missense_Mutation	p.I344V	3
NCK2	UCEC	chr2	106471637	106471637	C	T	Missense_Mutation	p.R40W	3
NCK2	CHOL	chr2	106471558	106471558	C	T	Silent		3
NCK2	CHOL	chr2	106471558	106471558	C	T	Silent	p.Y13Y	3
NCK2	UCEC	chr2	106471537	106471537	T	G	Missense_Mutation	p.I6M	2
NCK2	PAAD	chr2	106509467	106509467	G	A	Silent		2
NCK2	STAD	chr2	106497824	106497824	G	A	Silent	p.A89A	2
NCK2	SKCM	chr2	106498356	106498356	C	G	Missense_Mutation	p.P267A	2
NCK2	UCEC	chr2	106471619	106471619	G	A	Missense_Mutation	p.D34N	2
NCK2	STAD	chr2	106497989	106497989	C	G	Missense_Mutation	p.C144W	2
NCK2	SKCM	chr2	106498412	106498412	G	T	Missense_Mutation	p.W285C	2
NCK2	UCEC	chr2	106471675	106471675	G	A	Silent	p.P52	2
NCK2	KIRP	chr2	106498221	106498221	A	G	Missense_Mutation		2
NCK2	STAD	chr2	106497812	106497812	C	T	Silent	p.S85S	2
NCK2	SKCM	chr2	106498299	106498299	C	T	Missense_Mutation	p.P248S	2
NCK2	UCEC	chr2	106497898	106497898	T	A	Missense_Mutation	p.I114N	2
NCK2	HNSC	chr2	106497977	106497977	C	T	Silent	p.V140V	2
NCK2	KIRP	chr2	106471718	106471718	C	A	Missense_Mutation		2
NCK2	STAD	chr2	106497999	106497999	T	A	Missense_Mutation		2
NCK2	STAD	chr2	106497880	106497880	G	A	Missense_Mutation	p.R108H	2
NCK2	SKCM	chr2	106498219	106498219	C	T	Missense_Mutation	p.T221I	2
NCK2	UCEC	chr2	106498188	106498188	G	A	Missense_Mutation	p.E211K	2
NCK2	HNSC	chr2	106497993	106497993	G	A	Missense_Mutation	p.D146N	2
NCK2	UCEC	chr2	106509466	106509466	C	T	Missense_Mutation	p.A326V	2
NCK2	HNSC	chr2	106498068	106498068	G	A	Missense_Mutation	p.E171K	2
NCK2	STAD	chr2	106498373	106498373	C	T	Silent	p.T272T	2
NCK2	SKCM	chr2	106497949	106497949	C	T	Missense_Mutation	p.S131F	2
NCK2	STAD	chr2	106497999	106497999	T	A	Missense_Mutation	p.W148R	2
NCK2	CESC	chr2	106471654	106471654	C	A	Silent		2
NCK2	ESCA	chr2	106471692	106471692	G	T	Missense_Mutation	p.R58L	2
NCK2	HNSC	chr2	106498121	106498121	G	A	Silent	p.L188L	2
NCK2	LIHC	chr2	106471663	106471663	G	-	Frame_Shift_Del	p.T48fs	2
NCK2	ESCA	chr2	106471533	106471533	T	G	Missense_Mutation		2
NCK2	STAD	chr2	106498353	106498353	G	A	Missense_Mutation	p.A266T	2
NCK2	SARC	chr2	106498349	106498349	G	A	Silent		2
NCK2	LUAD	chr2	106498470	106498470	G	T	Nonsense_Mutation	p.E305*	2
NCK2	ESCA	chr2	106498469	106498469	G	A	Silent		2
NCK2	PAAD	chr2	106471526	106471526	G	A	Missense_Mutation		2
NCK2	STAD	chr2	106497875	106497875	C	T	Silent	p.A106A	2
NCK2	SARC	chr2	106471560	106471560	C	G	Missense_Mutation	p.T14S	2
NCK2	HNSC	chr2	106497876	106497876	G	A	Missense_Mutation	p.D107N	2
NCK2	ESCA	chr2	106498469	106498469	G	A	Silent	p.V304V	2
NCK2	PAAD	chr2	106498449	106498449	G	A	Missense_Mutation		2
NCK2	STAD	chr2	106509597	106509597	G	A	Missense_Mutation	p.G370R	2
NCK2	HNSC	chr2	106498429	106498429	C	T	Missense_Mutation		1
NCK2	COAD	chr2	106497917	106497917	C	T	Silent	p.F120F	1
NCK2	HNSC	chr2	106498358	106498358	A	G	Silent	p.P267P	1
NCK2	LUAD	chr2	106497870	106497870	G	A	Missense_Mutation	p.G105S	1
NCK2	SKCM	chr2	106497819	106497819	G	A	Missense_Mutation	p.D88N	1
NCK2	BLCA	chr2	106471515	106471515	G	C	Missense_Mutation		1
NCK2	ESCA	chr2	106498188	106498188	G	T	Nonsense_Mutation	p.E211X	1
NCK2	BLCA	chr2	106498419	106498419	G	A	Missense_Mutation	p.G288R	1
NCK2	HNSC	chr2	106509549	106509549	G	C	Missense_Mutation		1
NCK2	COAD	chr2	106498382	106498382	G	A	Silent	p.S275S	1
NCK2	LUAD	chr2	106498387	106498387	G	T	Missense_Mutation	p.S277I	1
NCK2	SKCM	chr2	106471673	106471673	C	T	Missense_Mutation	p.P52S	1
NCK2	BLCA	chr2	106509608	106509608	C	G	Silent		1
NCK2	HNSC	chr2	106497993	106497993	G	A	Missense_Mutation		1
NCK2	BLCA	chr2	106498105	106498105	G	A	Missense_Mutation	p.R183H	1
NCK2	HNSC	chr2	106509549	106509549	G	C	Missense_Mutation	p.E354Q	1
NCK2	LUAD	chr2	106498290	106498290	G	T	Missense_Mutation	p.G245C	1
NCK2	SKCM	chr2	106497906	106497906	T	A	Missense_Mutation	p.F117I	1
NCK2	BLCA	chr2	106498229	106498229	G	C	Silent		1
NCK2	HNSC	chr2	106498068	106498068	G	A	Missense_Mutation		1
NCK2	BLCA	chr2	106497939	106497939	G	A	Missense_Mutation	p.D128N	1
NCK2	COAD	chr2	106509531	106509531	C	T	Missense_Mutation	p.R348C	1
NCK2	LUAD	chr2	106497819	106497819	G	T	Missense_Mutation	p.D88Y	1
NCK2	HNSC	chr2	106497977	106497977	C	T	Silent		1
NCK2	BLCA	chr2	106498407	106498407	G	C	Missense_Mutation	p.E284Q	1
NCK2	COAD	chr2	106471730	106471730	C	T	Silent	p.L71L	1
NCK2	LIHC	chr2	106509478	106509478	A	G	Missense_Mutation		1
NCK2	LUAD	chr2	106497818	106497818	G	A	Silent	p.R87R	1
NCK2	STAD	chr2	106498373	106498373	C	T	Silent		1
NCK2	BLCA	chr2	106498419	106498419	G	A	Missense_Mutation		1
NCK2	HNSC	chr2	106497901	106497901	C	A	Missense_Mutation		1
NCK2	STAD	chr2	106498310	106498310	C	T	Silent	p.Y251Y	1
NCK2	LIHC	chr2	106498261	106498261	G	A	Nonsense_Mutation	p.W235X	1
NCK2	LUSC	chr2	106498233	106498233	G	C	Missense_Mutation	p.E226Q	1
NCK2	BLCA	chr2	106497939	106497939	G	A	Missense_Mutation		1
NCK2	HNSC	chr2	106498358	106498358	A	G	Silent		1
NCK2	READ	chr2	106497813	106497813	G	A	Missense_Mutation	p.A86T	1
NCK2	STAD	chr2	106471695	106471695	A	C	Missense_Mutation	p.K59T	1
NCK2	HNSC	chr2	106509493	106509493	T	C	Missense_Mutation	p.V335A	1
NCK2	ESCA	chr2	106498469	106498469	G	A	Silent	p.V304	1
NCK2	LIHC	chr2	106497846	106497846	G	A	Missense_Mutation	p.A97T	1
NCK2	LUSC	chr2	106498213	106498213	G	T	Missense_Mutation	p.G219V	1
NCK2	BLCA	chr2	106498407	106498407	G	C	Missense_Mutation		1
NCK2	HNSC	chr2	106497876	106497876	G	A	Missense_Mutation		1
NCK2	READ	chr2	106498143	106498143	G	A	Missense_Mutation	p.V196M	1
NCK2	SKCM	chr2	106498484	106498484	C	T	Silent	p.L309L	1
NCK2	HNSC	chr2	106497991	106497991	G	A	Missense_Mutation	p.S145N	1
NCK2	OV	chr2	105837967	105837967	A	T	Missense_Mutation		1
NCK2	STAD	chr2	106497888	106497888	G	A	Missense_Mutation	p.D111N	1
NCK2	SARC	chr2	106471560	106471560	C	G	Missense_Mutation		1
NCK2	BLCA	chr2	106498138	106498138	C	T	Missense_Mutation	p.S194F	1
NCK2	HNSC	chr2	106498121	106498121	G	A	Silent		1
NCK2	SKCM	chr2	106498298	106498298	C	T	Silent	p.V247V	1
NCK2	CESC	chr2	106471654	106471654	C	A	Silent	p.A45	1
NCK2	OV	chr2	105838035	105838035	G	T	Silent	p.R28	1
NCK2	UCEC	chr2	106509618	106509618	A	C	Silent	p.R377R	1
NCK2	BLCA	chr2	106509608	106509608	C	G	Silent	p.L373L	1
NCK2	HNSC	chr2	106497991	106497991	G	A	Missense_Mutation		1
NCK2	HNSC	chr2	106498429	106498429	C	T	Missense_Mutation	p.T291M	1
NCK2	SKCM	chr2	106498441	106498441	C	T	Missense_Mutation	p.A295V	1
NCK2	ACC	chr2	106471685	106471685	G	A	Missense_Mutation	p.V56M	1
NCK2	UCEC	chr2	106498291	106498291	G	T	Missense_Mutation	p.G245V	1
NCK2	BLCA	chr2	106498229	106498229	G	C	Silent	p.V224V	1
NCK2	HNSC	chr2	106509493	106509493	T	C	Missense_Mutation		1
NCK2	SKCM	chr2	106471561	106471561	C	T	Silent	p.T14T	1
NCK2	BLCA	chr2	106498138	106498138	C	T	Missense_Mutation		1

Copy number variation (CNV) of NCK2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NCK2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103286	OV	TCGA-25-1319	NCK2	chr2	106433070	+	ACTR3	chr2	114670748	+
103286	OV	TCGA-25-1319-01A	NCK2	chr2	106433070	+	ACTR3	chr2	114670749	+
100784	N/A	BI000173	NCK2	chr2	106481280	+	ATP6V0D1	chr16	67472368	-
97828	GBM	TCGA-06-5412-01A	NCK2	chr2	106471745	+	C2orf40	chr2	106688300	+
97828	UCS	TCGA-NG-A4VU	NCK2	chr2	106498505	+	C2orf40	chr2	106694221	+
83411	N/A	BF333117	NCK2	chr2	106429034	-	DDI2	chr1	15964848	+
97829	Non-Cancer	TCGA-BH-A0B8-11A	NCK2	chr2	106471745	+	FHL2	chr2	106002997	-
100804	PRAD	TCGA-G9-7525	NCK2	chr2	106361595	+	KDM4C	chr9	7165237	+
100804	PRAD	TCGA-G9-7525-01A	NCK2	chr2	106361595	+	KDM4C	chr9	7165238	+
90171	STAD	TCGA-HU-A4GH-01A	NCK2	chr2	106361595	+	LANCL1	chr2	211320038	-
81868	STAD	TCGA-VQ-A925	NCK2	chr2	106361595	+	MRPS9	chr2	105705441	+
81868	STAD	TCGA-VQ-A925-01A	NCK2	chr2	106361595	+	MRPS9	chr2	105705442	+
102402	Non-Cancer	TCGA-HU-A4GC-11A	NCK2	chr2	106433070	+	NFYC	chr1	41213205	+
97166	MESO	TCGA-ZN-A9VP	NCK2	chr2	106471745	+	NUP93	chr16	56782145	+
97166	MESO	TCGA-ZN-A9VP-01A	NCK2	chr2	106471745	+	NUP93	chr16	56782146	+
57615	N/A	BI491262	NCK2	chr2	106084765	-	PHF6	chrX	133555857	-
91993	OV	TCGA-25-2042	NCK2	chr2	106471745	+	RHOQ	chr2	46803225	+
100025	BRCA	TCGA-A8-A09I-01A	NCK2	chr2	106471745	+	SFXN5	chr2	73198814	-
101438	STAD	TCGA-BR-8296-01A	NCK2	chr2	106361595	+	TMEM131	chr2	98392481	-
102622	STAD	TCGA-BR-8485	NCK2	chr2	106471745	+	ZNF638	chr2	71645731	+
64051	N/A	BG029720	PDPR	chr16	70196432	+	NCK2	chr2	106374885	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	NCK2	0.000423946133907574	0.011
KIRC	NCK2	0.00135983853277719	0.035
SKCM	NCK2	0.0113869666865187	0.28
BLCA	NCK2	0.0155406360990489	0.37
PCPG	NCK2	0.0155747542126878	0.37
LIHC	NCK2	2.81793984006828e-10	7.9e-09

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	NCK2	0.000150683759235443	0.0048
LUSC	NCK2	0.0431748259376809	1
KICH	NCK2	0.0322297844849493	0.9
LGG	NCK2	0.0235126607111278	0.68
BRCA	NCK2	8.15373867598655e-08	2.7e-06
OV	NCK2	0.00932961052266558	0.29
THYM	NCK2	0.017459184647413	0.52

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source