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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF3A (NCBI Gene ID:8661)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF3A
	Gene ID: 8661
	Gene Symbol	EIF3A
	Gene ID	8661
	Gene Name	eukaryotic translation initiation factor 3 subunit A
	Synonyms	EIF3\|EIF3S10\|P167\|TIF32\|eIF3-p170\|eIF3-theta\|p180\|p185
	Cytomap	10q26.11
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 3 subunit AEIF3, p180 subunitcentrosomin homologcytoplasmic protein p167eIF-3-thetaeIF3 p167eIF3 p180eIF3 p185eukaryotic translation initiation factor 3 subunit 10eukaryotic translation initiation factor 3
	Modification date	20200313
	UniProtAcc	Q14152

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF3A	GO:0001732	formation of cytoplasmic translation initiation complex	17581632
Hgene	EIF3A	GO:0075522	IRES-dependent viral translational initiation	9573242\|23766293\|24357634
Hgene	EIF3A	GO:0075525	viral translational termination-reinitiation	21347434

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF3A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF3A[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF3A	Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	34887587

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000369144	120797749	120797951	Frame-shift
ENST00000541549	120797749	120797951	Frame-shift
ENST00000369144	120803565	120803654	Frame-shift
ENST00000541549	120803565	120803654	Frame-shift
ENST00000369144	120818723	120818909	In-frame
ENST00000541549	120818723	120818909	In-frame
ENST00000369144	120820735	120820840	In-frame
ENST00000541549	120820735	120820840	In-frame
ENST00000369144	120824910	120825082	Frame-shift
ENST00000541549	120824910	120825082	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000541549	120818723	120818909	4503	1535	1720	1382	447	509
ENST00000369144	120818723	120818909	5489	1572	1757	1382	481	543
ENST00000541549	120820735	120820840	4503	1214	1318	1382	340	375
ENST00000369144	120820735	120820840	5489	1251	1355	1382	374	409

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q14152	481	543	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
Q14152	374	409	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
Q14152	447	509	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
Q14152	340	375	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
Q14152	481	543	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01185
Q14152	374	409	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01185
Q14152	447	509	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01185
Q14152	340	375	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01185
Q14152	481	543	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
Q14152	447	509	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
Q14152	374	409	386	386	Natural variant	ID=VAR_024438;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs967185,PMID:14702039
Q14152	481	543	520	520	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q14152	340	375	336	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	340	375	346	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	340	375	354	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	374	409	367	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	340	375	367	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	374	409	377	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	374	409	385	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	374	409	400	416	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	447	509	448	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	447	509	452	458	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	447	509	464	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	481	543	483	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	447	509	483	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	481	543	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	447	509	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	481	543	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B
Q14152	447	509	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3J8B

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	EIF3A	1.13680328391952	0.000363360004697762
BLCA	EIF3A	-4.45104058307747	0.00532913208007812
BRCA	EIF3A	-1.218215573148	7.39403582934137e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
HNSC	EIF3A	-0.123161789	0.012495119
UVM	EIF3A	-0.107206767	0.034879621

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF3A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	EIF3A	POLR3A	0.80716187	2.64E-19
ACC	Epifactor	EIF3A	EPC1	0.813809603	7.82E-20
ACC	Epifactor	EIF3A	CUL2	0.822818575	1.39E-20
ACC	Epifactor	EIF3A	DDX21	0.887014413	1.47E-27
ACC	IUPHAR	EIF3A	SLK	0.801288837	7.45E-19
ACC	Kinase	EIF3A	SLK	0.801288837	7.45E-19
ACC	TSG	EIF3A	CUL2	0.822818575	1.39E-20
CESC	Epifactor	EIF3A	DDX21	0.876065563	6.04E-99
DLBC	Cell metabolism gene	EIF3A	NEU3	0.800610595	8.47E-12
DLBC	Cell metabolism gene	EIF3A	NCOA2	0.802058172	7.28E-12
DLBC	Cell metabolism gene	EIF3A	GLUD2	0.804882938	5.40E-12
DLBC	Cell metabolism gene	EIF3A	POLR3A	0.834105027	1.81E-13
DLBC	Cell metabolism gene	EIF3A	ARFGEF2	0.842982935	5.66E-14
DLBC	Cell metabolism gene	EIF3A	NCOR1	0.843898658	5.00E-14
DLBC	Cell metabolism gene	EIF3A	NUP153	0.861336433	3.99E-15
DLBC	CGC	EIF3A	ASXL2	0.800422883	8.63E-12
DLBC	CGC	EIF3A	NCOA2	0.802058172	7.28E-12
DLBC	CGC	EIF3A	STAG1	0.806118519	4.74E-12
DLBC	CGC	EIF3A	BARD1	0.811988709	2.50E-12
DLBC	CGC	EIF3A	NFATC2	0.826147503	4.86E-13
DLBC	CGC	EIF3A	BCOR	0.830958764	2.69E-13
DLBC	CGC	EIF3A	NCOR1	0.843898658	5.00E-14
DLBC	Epifactor	EIF3A	ASXL2	0.800422883	8.63E-12
DLBC	Epifactor	EIF3A	NCOA2	0.802058172	7.28E-12
DLBC	Epifactor	EIF3A	CTR9	0.807331784	4.16E-12
DLBC	Epifactor	EIF3A	BARD1	0.811988709	2.50E-12
DLBC	Epifactor	EIF3A	TET3	0.812214277	2.44E-12
DLBC	Epifactor	EIF3A	TAF1L	0.816583777	1.49E-12
DLBC	Epifactor	EIF3A	PPP4R2	0.81734015	1.37E-12
DLBC	Epifactor	EIF3A	RNF168	0.81735126	1.37E-12
DLBC	Epifactor	EIF3A	REST	0.824449846	5.96E-13
DLBC	Epifactor	EIF3A	BCOR	0.830958764	2.69E-13
DLBC	Epifactor	EIF3A	ATF2	0.831348219	2.56E-13
DLBC	Epifactor	EIF3A	SHPRH	0.834599676	1.70E-13
DLBC	Epifactor	EIF3A	SIRT1	0.837346747	1.19E-13
DLBC	Epifactor	EIF3A	NCOR1	0.843898658	5.00E-14
DLBC	Epifactor	EIF3A	DDX21	0.856732915	8.03E-15
DLBC	Epifactor	EIF3A	EPC1	0.864663096	2.37E-15
DLBC	Epifactor	EIF3A	TAF2	0.87211929	7.00E-16
DLBC	IUPHAR	EIF3A	NCOA2	0.802058172	7.28E-12
DLBC	IUPHAR	EIF3A	HIPK3	0.807526954	4.07E-12
DLBC	IUPHAR	EIF3A	TRPM7	0.812088886	2.47E-12
DLBC	IUPHAR	EIF3A	NR2C2	0.813727222	2.06E-12
DLBC	IUPHAR	EIF3A	ADAM10	0.81482058	1.82E-12
DLBC	IUPHAR	EIF3A	TAF1L	0.816583777	1.49E-12
DLBC	IUPHAR	EIF3A	TNKS2	0.820181635	9.86E-13
DLBC	IUPHAR	EIF3A	LMTK2	0.821594353	8.36E-13
DLBC	IUPHAR	EIF3A	SIRT1	0.837346747	1.19E-13
DLBC	Kinase	EIF3A	HIPK3	0.807526954	4.07E-12
DLBC	Kinase	EIF3A	TRPM7	0.812088886	2.47E-12
DLBC	Kinase	EIF3A	TAF1L	0.816583777	1.49E-12
DLBC	Kinase	EIF3A	LMTK2	0.821594353	8.36E-13
DLBC	TF	EIF3A	NCOA2	0.802058172	7.28E-12
DLBC	TF	EIF3A	PRR12	0.803405487	6.32E-12
DLBC	TF	EIF3A	ZNF710	0.807037921	4.29E-12
DLBC	TF	EIF3A	TET3	0.812214277	2.44E-12
DLBC	TF	EIF3A	NR2C2	0.813727222	2.06E-12
DLBC	TF	EIF3A	ZNF281	0.814337924	1.92E-12
DLBC	TF	EIF3A	REST	0.824449846	5.96E-13
DLBC	TF	EIF3A	ELF1	0.825230411	5.43E-13
DLBC	TF	EIF3A	ZNF430	0.825582074	5.20E-13
DLBC	TF	EIF3A	NFATC2	0.826147503	4.86E-13
DLBC	TF	EIF3A	ATF2	0.831348219	2.56E-13
DLBC	TF	EIF3A	ETV3	0.838878135	9.77E-14
DLBC	TSG	EIF3A	CCAR1	0.804011705	5.93E-12
DLBC	TSG	EIF3A	BARD1	0.811988709	2.50E-12
DLBC	TSG	EIF3A	NR2C2	0.813727222	2.06E-12
DLBC	TSG	EIF3A	NFATC2	0.826147503	4.86E-13
DLBC	TSG	EIF3A	SHPRH	0.834599676	1.70E-13
DLBC	TSG	EIF3A	SIRT1	0.837346747	1.19E-13
DLBC	TSG	EIF3A	RASSF3	0.837648828	1.15E-13
GBM	Cell metabolism gene	EIF3A	UPF2	0.807647072	7.60E-41
GBM	IUPHAR	EIF3A	SLK	0.833606877	1.10E-45
GBM	Kinase	EIF3A	SLK	0.833606877	1.10E-45
HNSC	Epifactor	EIF3A	DDX21	0.831571443	3.73E-146
KICH	CGC	EIF3A	CDK12	0.80457321	7.51E-22
KICH	CGC	EIF3A	ASXL2	0.805540186	6.16E-22
KICH	Epifactor	EIF3A	ASXL2	0.805540186	6.16E-22
KICH	Epifactor	EIF3A	BPTF	0.817036765	5.35E-23
KICH	Epifactor	EIF3A	DDX21	0.825565017	7.80E-24
KICH	IUPHAR	EIF3A	TAOK1	0.802744424	1.09E-21
KICH	IUPHAR	EIF3A	CDK12	0.80457321	7.51E-22
KICH	IUPHAR	EIF3A	TNKS2	0.812109024	1.56E-22
KICH	IUPHAR	EIF3A	BPTF	0.817036765	5.35E-23
KICH	IUPHAR	EIF3A	IDE	0.825121132	8.64E-24
KICH	IUPHAR	EIF3A	SLK	0.825457286	7.99E-24
KICH	Kinase	EIF3A	TAOK1	0.802744424	1.09E-21
KICH	Kinase	EIF3A	CDK12	0.80457321	7.51E-22
KICH	Kinase	EIF3A	SLK	0.825457286	7.99E-24
KICH	TF	EIF3A	BPTF	0.817036765	5.35E-23
KIRP	Cell metabolism gene	EIF3A	NCOA2	0.809460383	3.26E-76
KIRP	Cell metabolism gene	EIF3A	PRKAR2A	0.815893165	2.31E-78
KIRP	Cell metabolism gene	EIF3A	PAFAH1B2	0.819032192	1.92E-79
KIRP	Cell metabolism gene	EIF3A	KIF13A	0.81985194	9.96E-80
KIRP	Cell metabolism gene	EIF3A	POLR3A	0.828648465	6.92E-83
KIRP	CGC	EIF3A	ASXL2	0.804374963	1.43E-74
KIRP	CGC	EIF3A	NCOA2	0.809460383	3.26E-76
KIRP	CGC	EIF3A	STAG1	0.811196214	8.74E-77
KIRP	CGC	EIF3A	PAFAH1B2	0.819032192	1.92E-79
KIRP	Epifactor	EIF3A	USP12	0.802747542	4.70E-74
KIRP	Epifactor	EIF3A	ASXL2	0.804374963	1.43E-74
KIRP	Epifactor	EIF3A	NCOA2	0.809460383	3.26E-76
KIRP	Epifactor	EIF3A	PPP4R2	0.819193689	1.69E-79
KIRP	Epifactor	EIF3A	DDX21	0.868650905	6.26E-100
KIRP	IUPHAR	EIF3A	SLC25A40	0.806923396	2.18E-75
KIRP	IUPHAR	EIF3A	DPP8	0.808743032	5.60E-76
KIRP	IUPHAR	EIF3A	NCOA2	0.809460383	3.26E-76
KIRP	IUPHAR	EIF3A	PRKAR2A	0.815893165	2.31E-78
KIRP	IUPHAR	EIF3A	MAPK8	0.82504691	1.43E-81
KIRP	IUPHAR	EIF3A	IDE	0.837146964	4.10E-86
KIRP	Kinase	EIF3A	MAPK8	0.82504691	1.43E-81
KIRP	TF	EIF3A	ETV3	0.808802795	5.36E-76
KIRP	TF	EIF3A	NCOA2	0.809460383	3.26E-76
KIRP	TSG	EIF3A	USP12	0.802747542	4.70E-74
LIHC	Epifactor	EIF3A	DDX21	0.81536861	5.59E-102
LIHC	IUPHAR	EIF3A	SLK	0.802370722	2.07E-96
LIHC	Kinase	EIF3A	SLK	0.802370722	2.07E-96
MESO	Epifactor	EIF3A	DDX21	0.833796438	1.21E-23
PAAD	IUPHAR	EIF3A	IDE	0.808118003	1.81E-43
PCPG	Cell metabolism gene	EIF3A	NUP153	0.802801862	2.07E-43
PCPG	Cell metabolism gene	EIF3A	METTL2B	0.808663582	1.70E-44
PCPG	Cell metabolism gene	EIF3A	LONP2	0.8090782	1.42E-44
PCPG	Cell metabolism gene	EIF3A	NCOA2	0.811089937	5.90E-45
PCPG	Cell metabolism gene	EIF3A	MGAT5	0.821613508	4.96E-47
PCPG	Cell metabolism gene	EIF3A	GSR	0.836466218	3.32E-50
PCPG	Cell metabolism gene	EIF3A	KIF13A	0.837050919	2.45E-50
PCPG	Cell metabolism gene	EIF3A	UGCG	0.844853307	3.85E-52
PCPG	Cell metabolism gene	EIF3A	PAFAH1B2	0.84650683	1.55E-52
PCPG	Cell metabolism gene	EIF3A	GNA11	0.846753561	1.35E-52
PCPG	Cell metabolism gene	EIF3A	NUP155	0.857229515	3.22E-55
PCPG	Cell metabolism gene	EIF3A	XRN2	0.860705264	3.90E-56
PCPG	Cell metabolism gene	EIF3A	PRKAR2A	0.862631526	1.18E-56
PCPG	Cell metabolism gene	EIF3A	GLUD2	0.871619655	3.49E-59
PCPG	CGC	EIF3A	STAG1	0.809913021	9.88E-45
PCPG	CGC	EIF3A	NCOA2	0.811089937	5.90E-45
PCPG	CGC	EIF3A	TRIP11	0.812551569	3.09E-45
PCPG	CGC	EIF3A	NCOA4	0.832409578	2.62E-49
PCPG	CGC	EIF3A	PAFAH1B2	0.84650683	1.55E-52
PCPG	CGC	EIF3A	GNA11	0.846753561	1.35E-52
PCPG	CGC	EIF3A	STRN	0.849843225	2.39E-53
PCPG	CGC	EIF3A	IL6ST	0.849965884	2.23E-53
PCPG	CGC	EIF3A	ASXL2	0.858522743	1.48E-55
PCPG	Epifactor	EIF3A	ZRANB3	0.809855977	1.01E-44
PCPG	Epifactor	EIF3A	NCOA2	0.811089937	5.90E-45
PCPG	Epifactor	EIF3A	RBBP5	0.814373488	1.37E-45
PCPG	Epifactor	EIF3A	GTF2I	0.815864511	7.01E-46
PCPG	Epifactor	EIF3A	RNF168	0.81865054	1.96E-46
PCPG	Epifactor	EIF3A	PPP4R2	0.820086107	1.01E-46
PCPG	Epifactor	EIF3A	GTF3C4	0.85579568	7.57E-55
PCPG	Epifactor	EIF3A	ASXL2	0.858522743	1.48E-55
PCPG	Epifactor	EIF3A	SMARCA5	0.86776956	4.46E-58
PCPG	Epifactor	EIF3A	DDX21	0.905763134	6.79E-71
PCPG	IUPHAR	EIF3A	ERN1	0.800977728	4.42E-43
PCPG	IUPHAR	EIF3A	SAMD8	0.810936024	6.31E-45
PCPG	IUPHAR	EIF3A	NCOA2	0.811089937	5.90E-45
PCPG	IUPHAR	EIF3A	SCYL2	0.811442792	5.05E-45
PCPG	IUPHAR	EIF3A	PXK	0.818285949	2.32E-46
PCPG	IUPHAR	EIF3A	SLK	0.820396602	8.75E-47
PCPG	IUPHAR	EIF3A	HIPK3	0.8243262	1.37E-47
PCPG	IUPHAR	EIF3A	SLC25A40	0.827985771	2.35E-48
PCPG	IUPHAR	EIF3A	DPP8	0.828573082	1.76E-48
PCPG	IUPHAR	EIF3A	GSR	0.836466218	3.32E-50
PCPG	IUPHAR	EIF3A	UGCG	0.844853307	3.85E-52
PCPG	IUPHAR	EIF3A	LMTK2	0.845594222	2.56E-52
PCPG	IUPHAR	EIF3A	IL6ST	0.849965884	2.23E-53
PCPG	IUPHAR	EIF3A	GTF3C4	0.85579568	7.57E-55
PCPG	IUPHAR	EIF3A	ADAM10	0.858248062	1.75E-55
PCPG	IUPHAR	EIF3A	PRKAR2A	0.862631526	1.18E-56
PCPG	Kinase	EIF3A	ERN1	0.800977728	4.42E-43
PCPG	Kinase	EIF3A	SCYL2	0.811442792	5.05E-45
PCPG	Kinase	EIF3A	PXK	0.818285949	2.32E-46
PCPG	Kinase	EIF3A	SLK	0.820396602	8.75E-47
PCPG	Kinase	EIF3A	HIPK3	0.8243262	1.37E-47
PCPG	Kinase	EIF3A	LMTK2	0.845594222	2.56E-52
PCPG	TF	EIF3A	ZNF134	0.804719884	9.22E-44
PCPG	TF	EIF3A	ZNF689	0.808205794	2.07E-44
PCPG	TF	EIF3A	ZNF281	0.810804194	6.68E-45
PCPG	TF	EIF3A	NCOA2	0.811089937	5.90E-45
PCPG	TF	EIF3A	GTF2I	0.815864511	7.01E-46
PCPG	TF	EIF3A	ZNF699	0.817029651	4.13E-46
PCPG	TF	EIF3A	ATF6	0.841334552	2.58E-51
PCPG	TF	EIF3A	ZNF641	0.841552989	2.29E-51
PCPG	TF	EIF3A	ZNF426	0.876302531	1.41E-60
PCPG	TSG	EIF3A	NCOA4	0.832409578	2.62E-49
PRAD	Cell metabolism gene	EIF3A	PRKAR2A	0.801280875	2.37E-124
PRAD	Epifactor	EIF3A	DDX21	0.847343327	9.47E-153
PRAD	IUPHAR	EIF3A	PRKAR2A	0.801280875	2.37E-124
PRAD	IUPHAR	EIF3A	LMTK2	0.806133356	5.63E-127
PRAD	Kinase	EIF3A	LMTK2	0.806133356	5.63E-127
SKCM	Epifactor	EIF3A	DDX21	0.823485396	2.90E-118
TGCT	Cell metabolism gene	EIF3A	NUP153	0.803578877	1.58E-36
TGCT	Cell metabolism gene	EIF3A	NCOA2	0.826430889	2.96E-40
TGCT	Cell metabolism gene	EIF3A	POLR3A	0.84922478	1.47E-44
TGCT	CGC	EIF3A	NCOA2	0.826430889	2.96E-40
TGCT	CGC	EIF3A	ASXL2	0.839680994	1.13E-42
TGCT	CGC	EIF3A	BARD1	0.856540803	4.29E-46
TGCT	Epifactor	EIF3A	PPP4R2	0.809024826	2.27E-37
TGCT	Epifactor	EIF3A	REST	0.81167467	8.65E-38
TGCT	Epifactor	EIF3A	RNF168	0.8118228	8.19E-38
TGCT	Epifactor	EIF3A	RBBP5	0.81990226	3.89E-39
TGCT	Epifactor	EIF3A	NCOA2	0.826430889	2.96E-40
TGCT	Epifactor	EIF3A	ASXL2	0.839680994	1.13E-42
TGCT	Epifactor	EIF3A	BARD1	0.856540803	4.29E-46
TGCT	IUPHAR	EIF3A	SLK	0.800481476	4.64E-36
TGCT	IUPHAR	EIF3A	DPP8	0.823050397	1.14E-39
TGCT	IUPHAR	EIF3A	NCOA2	0.826430889	2.96E-40
TGCT	IUPHAR	EIF3A	SLC30A6	0.845146123	9.72E-44
TGCT	Kinase	EIF3A	SLK	0.800481476	4.64E-36
TGCT	TF	EIF3A	ZNF791	0.801424712	3.35E-36
TGCT	TF	EIF3A	REST	0.81167467	8.65E-38
TGCT	TF	EIF3A	ZNF430	0.811834314	8.15E-38
TGCT	TF	EIF3A	ZNF281	0.81673716	1.31E-38
TGCT	TF	EIF3A	NCOA2	0.826430889	2.96E-40
TGCT	TF	EIF3A	ZNF829	0.831689408	3.44E-41
TGCT	TF	EIF3A	ETV3	0.836151848	5.21E-42
TGCT	TF	EIF3A	ZNF551	0.874051588	3.84E-50
TGCT	TSG	EIF3A	BARD1	0.856540803	4.29E-46
THCA	Cell metabolism gene	EIF3A	MAN1A2	0.801199813	3.19E-129
THCA	Cell metabolism gene	EIF3A	MAN2A1	0.807501688	8.82E-133
THCA	Cell metabolism gene	EIF3A	PHAX	0.808345375	2.88E-133
THCA	Cell metabolism gene	EIF3A	NEU3	0.808459917	2.47E-133
THCA	Cell metabolism gene	EIF3A	SPTLC2	0.811687706	3.22E-135
THCA	Cell metabolism gene	EIF3A	UGCG	0.813294427	3.60E-136
THCA	Cell metabolism gene	EIF3A	PDP2	0.815970714	8.92E-138
THCA	Cell metabolism gene	EIF3A	GSR	0.825497405	1.03E-143
THCA	Cell metabolism gene	EIF3A	CLOCK	0.829357174	3.20E-146
THCA	Cell metabolism gene	EIF3A	MGAT5	0.832451783	2.80E-148
THCA	Cell metabolism gene	EIF3A	IPMK	0.835540089	2.25E-150
THCA	Cell metabolism gene	EIF3A	PIK3CA	0.848288164	1.64E-159
THCA	Cell metabolism gene	EIF3A	SEC24B	0.848561352	1.02E-159
THCA	Cell metabolism gene	EIF3A	NUP155	0.849424949	2.29E-160
THCA	Cell metabolism gene	EIF3A	NCOA2	0.851103379	1.21E-161
THCA	Cell metabolism gene	EIF3A	MED1	0.853028152	3.99E-163
THCA	Cell metabolism gene	EIF3A	GLUD2	0.856001324	1.85E-165
THCA	Cell metabolism gene	EIF3A	GNA11	0.857821905	6.51E-167
THCA	Cell metabolism gene	EIF3A	XRN2	0.868366649	9.35E-176
THCA	Cell metabolism gene	EIF3A	PRKAR2A	0.876005421	1.18E-182
THCA	Cell metabolism gene	EIF3A	PAFAH1B2	0.879103228	1.39E-185
THCA	CGC	EIF3A	CDK12	0.808100768	3.98E-133
THCA	CGC	EIF3A	STAG1	0.829598398	2.22E-146
THCA	CGC	EIF3A	AFF4	0.831339534	1.55E-147
THCA	CGC	EIF3A	PTPN11	0.837776158	6.40E-152
THCA	CGC	EIF3A	TRIP11	0.844503343	1.03E-156
THCA	CGC	EIF3A	LATS1	0.847876791	3.33E-159
THCA	CGC	EIF3A	PIK3CA	0.848288164	1.64E-159
THCA	CGC	EIF3A	NCOA2	0.851103379	1.21E-161
THCA	CGC	EIF3A	IL6ST	0.855013948	1.12E-164
THCA	CGC	EIF3A	GNA11	0.857821905	6.51E-167
THCA	CGC	EIF3A	STRN	0.877426785	5.48E-184
THCA	CGC	EIF3A	PAFAH1B2	0.879103228	1.39E-185
THCA	CGC	EIF3A	ASXL2	0.891699722	2.22E-198
THCA	Epifactor	EIF3A	TAF1L	0.804597522	3.99E-131
THCA	Epifactor	EIF3A	BAZ1B	0.809658909	4.98E-134
THCA	Epifactor	EIF3A	RSF1	0.816153217	6.92E-138
THCA	Epifactor	EIF3A	CSNK2A1	0.816468639	4.46E-138
THCA	Epifactor	EIF3A	GTF3C4	0.816482743	4.37E-138
THCA	Epifactor	EIF3A	UBE2H	0.817193419	1.61E-138
THCA	Epifactor	EIF3A	EYA3	0.823451944	2.08E-142
THCA	Epifactor	EIF3A	SMARCA5	0.824296329	6.05E-143
THCA	Epifactor	EIF3A	PARG	0.825697272	7.68E-144
THCA	Epifactor	EIF3A	CLOCK	0.829357174	3.20E-146
THCA	Epifactor	EIF3A	ATF2	0.831228203	1.84E-147
THCA	Epifactor	EIF3A	GTF2I	0.835077546	4.66E-150
THCA	Epifactor	EIF3A	RNF168	0.838224967	3.12E-152
THCA	Epifactor	EIF3A	REST	0.840599212	6.64E-154
THCA	Epifactor	EIF3A	NCOA2	0.851103379	1.21E-161
THCA	Epifactor	EIF3A	MAP3K7	0.854127462	5.55E-164
THCA	Epifactor	EIF3A	USP12	0.855201089	7.96E-165
THCA	Epifactor	EIF3A	RBBP5	0.875887478	1.52E-182
THCA	Epifactor	EIF3A	PPP4R2	0.875899113	1.48E-182
THCA	Epifactor	EIF3A	ASXL2	0.891699722	2.22E-198
THCA	Epifactor	EIF3A	DDX21	0.909867836	6.19E-220
THCA	IUPHAR	EIF3A	LNPEP	0.801830837	1.42E-129
THCA	IUPHAR	EIF3A	TAF1L	0.804597522	3.99E-131
THCA	IUPHAR	EIF3A	CDK12	0.808100768	3.98E-133
THCA	IUPHAR	EIF3A	BAZ1B	0.809658909	4.98E-134
THCA	IUPHAR	EIF3A	PDPK1	0.81016294	2.53E-134
THCA	IUPHAR	EIF3A	ADAM17	0.810991506	8.27E-135
THCA	IUPHAR	EIF3A	SPTLC2	0.811687706	3.22E-135
THCA	IUPHAR	EIF3A	UGCG	0.813294427	3.60E-136
THCA	IUPHAR	EIF3A	TAOK1	0.814488056	6.97E-137
THCA	IUPHAR	EIF3A	USP1	0.816104977	7.40E-138
THCA	IUPHAR	EIF3A	CSNK2A1	0.816468639	4.46E-138
THCA	IUPHAR	EIF3A	GTF3C4	0.816482743	4.37E-138
THCA	IUPHAR	EIF3A	GSR	0.825497405	1.03E-143
THCA	IUPHAR	EIF3A	SLC30A6	0.826141762	3.98E-144
THCA	IUPHAR	EIF3A	CLOCK	0.829357174	3.20E-146
THCA	IUPHAR	EIF3A	SLC30A5	0.831619817	1.01E-147
THCA	IUPHAR	EIF3A	HIPK3	0.83546665	2.52E-150
THCA	IUPHAR	EIF3A	DPP8	0.836334281	6.39E-151
THCA	IUPHAR	EIF3A	ERN1	0.839638311	3.18E-153
THCA	IUPHAR	EIF3A	LATS1	0.847876791	3.33E-159
THCA	IUPHAR	EIF3A	PIK3CA	0.848288164	1.64E-159
THCA	IUPHAR	EIF3A	SLK	0.850789717	2.10E-161
THCA	IUPHAR	EIF3A	NCOA2	0.851103379	1.21E-161
THCA	IUPHAR	EIF3A	MAP3K7	0.854127462	5.55E-164
THCA	IUPHAR	EIF3A	IL6ST	0.855013948	1.12E-164
THCA	IUPHAR	EIF3A	IDE	0.856601153	6.18E-166
THCA	IUPHAR	EIF3A	SCYL2	0.857154485	2.23E-166
THCA	IUPHAR	EIF3A	SLC25A40	0.857409918	1.39E-166
THCA	IUPHAR	EIF3A	LMTK2	0.862171799	1.80E-170
THCA	IUPHAR	EIF3A	ADAM10	0.867040903	1.33E-174
THCA	IUPHAR	EIF3A	CLCN3	0.868731192	4.48E-176
THCA	IUPHAR	EIF3A	PRKAR2A	0.876005421	1.18E-182
THCA	IUPHAR	EIF3A	MAP3K2	0.890660031	2.89E-197
THCA	Kinase	EIF3A	TAF1L	0.804597522	3.99E-131
THCA	Kinase	EIF3A	CDK12	0.808100768	3.98E-133
THCA	Kinase	EIF3A	BAZ1B	0.809658909	4.98E-134
THCA	Kinase	EIF3A	PDPK1	0.81016294	2.53E-134
THCA	Kinase	EIF3A	TAOK1	0.814488056	6.97E-137
THCA	Kinase	EIF3A	CSNK2A1	0.816468639	4.46E-138
THCA	Kinase	EIF3A	HIPK3	0.83546665	2.52E-150
THCA	Kinase	EIF3A	ERN1	0.839638311	3.18E-153
THCA	Kinase	EIF3A	LATS1	0.847876791	3.33E-159
THCA	Kinase	EIF3A	SLK	0.850789717	2.10E-161
THCA	Kinase	EIF3A	MAP3K7	0.854127462	5.55E-164
THCA	Kinase	EIF3A	SCYL2	0.857154485	2.23E-166
THCA	Kinase	EIF3A	LMTK2	0.862171799	1.80E-170
THCA	Kinase	EIF3A	MAP3K2	0.890660031	2.89E-197
THCA	TF	EIF3A	ZNF281	0.802346312	7.34E-130
THCA	TF	EIF3A	NFIC	0.809208668	9.10E-134
THCA	TF	EIF3A	ZNF689	0.813452637	2.90E-136
THCA	TF	EIF3A	ZNF813	0.816301467	5.63E-138
THCA	TF	EIF3A	ZNF623	0.819121611	1.06E-139
THCA	TF	EIF3A	ZNF134	0.823526984	1.87E-142
THCA	TF	EIF3A	ZNF28	0.82792373	2.78E-145
THCA	TF	EIF3A	CLOCK	0.829357174	3.20E-146
THCA	TF	EIF3A	ATF2	0.831228203	1.84E-147
THCA	TF	EIF3A	GTF2I	0.835077546	4.66E-150
THCA	TF	EIF3A	ETV3	0.836864633	2.75E-151
THCA	TF	EIF3A	REST	0.840599212	6.64E-154
THCA	TF	EIF3A	NCOA2	0.851103379	1.21E-161
THCA	TF	EIF3A	ZNF426	0.855343278	6.15E-165
THCA	TF	EIF3A	ATF6	0.866584577	3.30E-174
THCA	TF	EIF3A	ZFP91	0.884952695	2.44E-191
THCA	TSG	EIF3A	RNF111	0.819102936	1.09E-139
THCA	TSG	EIF3A	EAF1	0.821411268	4.01E-141
THCA	TSG	EIF3A	ANAPC1	0.823805475	1.24E-142
THCA	TSG	EIF3A	PTPN11	0.837776158	6.40E-152
THCA	TSG	EIF3A	LATS1	0.847876791	3.33E-159
THCA	TSG	EIF3A	USP12	0.855201089	7.96E-165
THYM	Cell metabolism gene	EIF3A	POLR1B	0.800860524	1.71E-28
THYM	Cell metabolism gene	EIF3A	B3GNT2	0.801411624	1.48E-28
THYM	Cell metabolism gene	EIF3A	GLS	0.802606989	1.07E-28
THYM	Cell metabolism gene	EIF3A	NCOA6	0.802879876	9.92E-29
THYM	Cell metabolism gene	EIF3A	SYNJ2	0.808836335	1.91E-29
THYM	Cell metabolism gene	EIF3A	IPMK	0.813766233	4.65E-30
THYM	Cell metabolism gene	EIF3A	MTM1	0.816914599	1.85E-30
THYM	Cell metabolism gene	EIF3A	NCOA2	0.818964563	1.00E-30
THYM	Cell metabolism gene	EIF3A	MED1	0.823959319	2.20E-31
THYM	Cell metabolism gene	EIF3A	MUT	0.829665176	3.64E-32
THYM	Cell metabolism gene	EIF3A	MAN2A1	0.83055986	2.73E-32
THYM	Cell metabolism gene	EIF3A	PIK3CA	0.832060877	1.68E-32
THYM	Cell metabolism gene	EIF3A	MED17	0.833461666	1.06E-32
THYM	Cell metabolism gene	EIF3A	PATL1	0.834716947	7.02E-33
THYM	Cell metabolism gene	EIF3A	UGCG	0.835328427	5.73E-33
THYM	Cell metabolism gene	EIF3A	SPTLC2	0.835620716	5.20E-33
THYM	Cell metabolism gene	EIF3A	NCOR1	0.838697498	1.84E-33
THYM	Cell metabolism gene	EIF3A	AASDHPPT	0.842741821	4.56E-34
THYM	Cell metabolism gene	EIF3A	CDK8	0.852267173	1.45E-35
THYM	Cell metabolism gene	EIF3A	ARFGEF2	0.855130375	4.89E-36
THYM	Cell metabolism gene	EIF3A	MANEA	0.857434096	2.01E-36
THYM	Cell metabolism gene	EIF3A	PAFAH1B2	0.857566194	1.91E-36
THYM	Cell metabolism gene	EIF3A	NEU3	0.860889982	5.13E-37
THYM	Cell metabolism gene	EIF3A	POLR2B	0.864571215	1.15E-37
THYM	Cell metabolism gene	EIF3A	RQCD1	0.869892386	1.22E-38
THYM	Cell metabolism gene	EIF3A	PIKFYVE	0.872005121	4.90E-39
THYM	Cell metabolism gene	EIF3A	UPF2	0.885345232	1.00E-41
THYM	Cell metabolism gene	EIF3A	POLR3A	0.887788621	2.96E-42
THYM	Cell metabolism gene	EIF3A	XRN2	0.889728484	1.10E-42
THYM	Cell metabolism gene	EIF3A	GLUD2	0.893192356	1.81E-43
THYM	Cell metabolism gene	EIF3A	NUP153	0.902867403	8.16E-46
THYM	CGC	EIF3A	HIP1	0.800193045	2.05E-28
THYM	CGC	EIF3A	ERCC4	0.801032323	1.64E-28
THYM	CGC	EIF3A	ARID1A	0.809011024	1.81E-29
THYM	CGC	EIF3A	CDC73	0.809629202	1.52E-29
THYM	CGC	EIF3A	WRN	0.81084763	1.08E-29
THYM	CGC	EIF3A	UBR5	0.813128403	5.59E-30
THYM	CGC	EIF3A	TRRAP	0.814054479	4.28E-30
THYM	CGC	EIF3A	ASXL2	0.818807192	1.05E-30
THYM	CGC	EIF3A	NCOA2	0.818964563	1.00E-30
THYM	CGC	EIF3A	BRCA2	0.819096317	9.65E-31
THYM	CGC	EIF3A	BCOR	0.824134985	2.08E-31
THYM	CGC	EIF3A	PIK3CA	0.832060877	1.68E-32
THYM	CGC	EIF3A	NUP98	0.835616572	5.20E-33
THYM	CGC	EIF3A	BRD4	0.838013685	2.32E-33
THYM	CGC	EIF3A	NCOR1	0.838697498	1.84E-33
THYM	CGC	EIF3A	ARID1B	0.83976285	1.28E-33
THYM	CGC	EIF3A	N4BP2	0.840394651	1.03E-33
THYM	CGC	EIF3A	PPM1D	0.843294379	3.76E-34
THYM	CGC	EIF3A	BIRC6	0.852806179	1.18E-35
THYM	CGC	EIF3A	PAFAH1B2	0.857566194	1.91E-36
THYM	CGC	EIF3A	PTPN11	0.860598791	5.76E-37
THYM	CGC	EIF3A	ATF1	0.868217146	2.51E-38
THYM	CGC	EIF3A	VHL	0.876545182	6.45E-40
THYM	CGC	EIF3A	STRN	0.876902054	5.48E-40
THYM	CGC	EIF3A	MLLT10	0.87698023	5.29E-40
THYM	CGC	EIF3A	BRD3	0.877236516	4.71E-40
THYM	CGC	EIF3A	BARD1	0.8781355	3.11E-40
THYM	CGC	EIF3A	FUBP1	0.906003044	1.25E-46
THYM	CGC	EIF3A	STAG1	0.908793985	2.23E-47
THYM	Epifactor	EIF3A	NCOA6	0.802879876	9.92E-29
THYM	Epifactor	EIF3A	TET3	0.804549882	6.28E-29
THYM	Epifactor	EIF3A	RSF1	0.805432123	4.93E-29
THYM	Epifactor	EIF3A	TP53BP1	0.80739474	2.86E-29
THYM	Epifactor	EIF3A	WHSC1L1	0.80760616	2.69E-29
THYM	Epifactor	EIF3A	WAC	0.807815578	2.54E-29
THYM	Epifactor	EIF3A	ARID1A	0.809011024	1.81E-29
THYM	Epifactor	EIF3A	CDC73	0.809629202	1.52E-29
THYM	Epifactor	EIF3A	CTR9	0.811736194	8.35E-30
THYM	Epifactor	EIF3A	MPHOSPH8	0.81293684	5.91E-30
THYM	Epifactor	EIF3A	TAF1	0.813085123	5.67E-30
THYM	Epifactor	EIF3A	UBR5	0.813128403	5.59E-30
THYM	Epifactor	EIF3A	TRRAP	0.814054479	4.28E-30
THYM	Epifactor	EIF3A	SMEK2	0.814965996	3.28E-30
THYM	Epifactor	EIF3A	ASXL2	0.818807192	1.05E-30
THYM	Epifactor	EIF3A	NCOA2	0.818964563	1.00E-30
THYM	Epifactor	EIF3A	BRCA2	0.819096317	9.65E-31
THYM	Epifactor	EIF3A	BCOR	0.824134985	2.08E-31
THYM	Epifactor	EIF3A	RBBP4	0.824181062	2.05E-31
THYM	Epifactor	EIF3A	CUL2	0.827917161	6.36E-32
THYM	Epifactor	EIF3A	ZNF217	0.833213351	1.15E-32
THYM	Epifactor	EIF3A	EPC2	0.833294213	1.12E-32
THYM	Epifactor	EIF3A	SIRT1	0.833925456	9.12E-33
THYM	Epifactor	EIF3A	GLYR1	0.83654247	3.82E-33
THYM	Epifactor	EIF3A	BRD4	0.838013685	2.32E-33
THYM	Epifactor	EIF3A	NCOR1	0.838697498	1.84E-33
THYM	Epifactor	EIF3A	USP12	0.838931135	1.70E-33
THYM	Epifactor	EIF3A	ARID1B	0.83976285	1.28E-33
THYM	Epifactor	EIF3A	TAF1L	0.842170456	5.57E-34
THYM	Epifactor	EIF3A	MAP3K7	0.846505906	1.20E-34
THYM	Epifactor	EIF3A	GTF2I	0.852667819	1.24E-35
THYM	Epifactor	EIF3A	JMJD1C	0.854524097	6.16E-36
THYM	Epifactor	EIF3A	BRPF3	0.857472117	1.98E-36
THYM	Epifactor	EIF3A	PHF8	0.858891608	1.13E-36
THYM	Epifactor	EIF3A	RNF168	0.861512118	4.00E-37
THYM	Epifactor	EIF3A	ADNP	0.863153499	2.06E-37
THYM	Epifactor	EIF3A	FAM175B	0.868620729	2.11E-38
THYM	Epifactor	EIF3A	PARG	0.86915052	1.68E-38
THYM	Epifactor	EIF3A	REST	0.876646129	6.16E-40
THYM	Epifactor	EIF3A	MLLT10	0.87698023	5.29E-40
THYM	Epifactor	EIF3A	SMARCAD1	0.877178783	4.83E-40
THYM	Epifactor	EIF3A	BRD3	0.877236516	4.71E-40
THYM	Epifactor	EIF3A	ATF2	0.877249752	4.68E-40
THYM	Epifactor	EIF3A	BARD1	0.8781355	3.11E-40
THYM	Epifactor	EIF3A	TAF2	0.879707885	1.50E-40
THYM	Epifactor	EIF3A	RBBP5	0.879789791	1.44E-40
THYM	Epifactor	EIF3A	SHPRH	0.886712706	5.08E-42
THYM	Epifactor	EIF3A	BPTF	0.88999906	9.61E-43
THYM	Epifactor	EIF3A	C11orf30	0.892165032	3.11E-43
THYM	Epifactor	EIF3A	EPC1	0.896042721	3.89E-44
THYM	Epifactor	EIF3A	ZRANB3	0.89969189	5.10E-45
THYM	Epifactor	EIF3A	TADA2A	0.902469941	1.03E-45
THYM	Epifactor	EIF3A	PPP4R2	0.905446672	1.75E-46
THYM	Epifactor	EIF3A	SMARCA5	0.905495688	1.70E-46
THYM	Epifactor	EIF3A	DDX21	0.915982613	2.02E-49
THYM	IUPHAR	EIF3A	GLS	0.802606989	1.07E-28
THYM	IUPHAR	EIF3A	SLC30A5	0.806468146	3.70E-29
THYM	IUPHAR	EIF3A	SYNJ2	0.808836335	1.91E-29
THYM	IUPHAR	EIF3A	SLC4A7	0.809944502	1.39E-29
THYM	IUPHAR	EIF3A	ATP13A3	0.810818441	1.09E-29
THYM	IUPHAR	EIF3A	SLC35A3	0.812475159	6.76E-30
THYM	IUPHAR	EIF3A	LMTK2	0.81253169	6.65E-30
THYM	IUPHAR	EIF3A	NPEPPS	0.812888689	6.00E-30
THYM	IUPHAR	EIF3A	SLC10A7	0.81289662	5.98E-30
THYM	IUPHAR	EIF3A	TAF1	0.813085123	5.67E-30
THYM	IUPHAR	EIF3A	TRRAP	0.814054479	4.28E-30
THYM	IUPHAR	EIF3A	NEK1	0.814909004	3.33E-30
THYM	IUPHAR	EIF3A	SLC35E3	0.815732008	2.62E-30
THYM	IUPHAR	EIF3A	NCOA2	0.818964563	1.00E-30
THYM	IUPHAR	EIF3A	SLC30A6	0.826111553	1.12E-31
THYM	IUPHAR	EIF3A	PDPK1	0.830426276	2.85E-32
THYM	IUPHAR	EIF3A	NEK7	0.831025048	2.35E-32
THYM	IUPHAR	EIF3A	PIK3CA	0.832060877	1.68E-32
THYM	IUPHAR	EIF3A	HIPK3	0.832890895	1.28E-32
THYM	IUPHAR	EIF3A	SIRT1	0.833925456	9.12E-33
THYM	IUPHAR	EIF3A	UGCG	0.835328427	5.73E-33
THYM	IUPHAR	EIF3A	SPTLC2	0.835620716	5.20E-33
THYM	IUPHAR	EIF3A	NEK4	0.837907751	2.41E-33
THYM	IUPHAR	EIF3A	BRD4	0.838013685	2.32E-33
THYM	IUPHAR	EIF3A	WNK1	0.840124439	1.13E-33
THYM	IUPHAR	EIF3A	TAF1L	0.842170456	5.57E-34
THYM	IUPHAR	EIF3A	PPM1D	0.843294379	3.76E-34
THYM	IUPHAR	EIF3A	SLC38A7	0.844707733	2.28E-34
THYM	IUPHAR	EIF3A	SLC25A24	0.844846676	2.17E-34
THYM	IUPHAR	EIF3A	MAP3K7	0.846505906	1.20E-34
THYM	IUPHAR	EIF3A	ADAM17	0.850540754	2.75E-35
THYM	IUPHAR	EIF3A	TNKS2	0.851965611	1.62E-35
THYM	IUPHAR	EIF3A	DPP8	0.852073866	1.56E-35
THYM	IUPHAR	EIF3A	CDK8	0.852267173	1.45E-35
THYM	IUPHAR	EIF3A	BIRC6	0.852806179	1.18E-35
THYM	IUPHAR	EIF3A	JMJD1C	0.854524097	6.16E-36
THYM	IUPHAR	EIF3A	BRPF3	0.857472117	1.98E-36
THYM	IUPHAR	EIF3A	PHF8	0.858891608	1.13E-36
THYM	IUPHAR	EIF3A	PIKFYVE	0.872005121	4.90E-39
THYM	IUPHAR	EIF3A	IDE	0.873238911	2.84E-39
THYM	IUPHAR	EIF3A	SLC25A40	0.87662977	6.21E-40
THYM	IUPHAR	EIF3A	BRD3	0.877236516	4.71E-40
THYM	IUPHAR	EIF3A	NR2C2	0.886904073	4.62E-42
THYM	IUPHAR	EIF3A	BPTF	0.88999906	9.61E-43
THYM	IUPHAR	EIF3A	SLK	0.899866207	4.62E-45
THYM	IUPHAR	EIF3A	SCYL2	0.901729392	1.58E-45
THYM	IUPHAR	EIF3A	ADAM10	0.913798753	8.80E-49
THYM	IUPHAR	EIF3A	MAPK8	0.914072427	7.33E-49
THYM	Kinase	EIF3A	LMTK2	0.81253169	6.65E-30
THYM	Kinase	EIF3A	TAF1	0.813085123	5.67E-30
THYM	Kinase	EIF3A	TRRAP	0.814054479	4.28E-30
THYM	Kinase	EIF3A	NEK1	0.814909004	3.33E-30
THYM	Kinase	EIF3A	PDPK1	0.830426276	2.85E-32
THYM	Kinase	EIF3A	NEK7	0.831025048	2.35E-32
THYM	Kinase	EIF3A	HIPK3	0.832890895	1.28E-32
THYM	Kinase	EIF3A	NEK4	0.837907751	2.41E-33
THYM	Kinase	EIF3A	BRD4	0.838013685	2.32E-33
THYM	Kinase	EIF3A	WNK1	0.840124439	1.13E-33
THYM	Kinase	EIF3A	TAF1L	0.842170456	5.57E-34
THYM	Kinase	EIF3A	MAP3K7	0.846505906	1.20E-34
THYM	Kinase	EIF3A	CDK8	0.852267173	1.45E-35
THYM	Kinase	EIF3A	BRD3	0.877236516	4.71E-40
THYM	Kinase	EIF3A	SLK	0.899866207	4.62E-45
THYM	Kinase	EIF3A	SCYL2	0.901729392	1.58E-45
THYM	Kinase	EIF3A	MAPK8	0.914072427	7.33E-49
THYM	TF	EIF3A	ZNF397	0.800155803	2.07E-28
THYM	TF	EIF3A	ZNF627	0.800984733	1.66E-28
THYM	TF	EIF3A	ZNF776	0.802617452	1.07E-28
THYM	TF	EIF3A	ELK3	0.80306744	9.43E-29
THYM	TF	EIF3A	TET3	0.804549882	6.28E-29
THYM	TF	EIF3A	ZNF407	0.805635067	4.66E-29
THYM	TF	EIF3A	KLF7	0.806491455	3.67E-29
THYM	TF	EIF3A	ZNF225	0.807411766	2.84E-29
THYM	TF	EIF3A	ZBTB10	0.807611536	2.69E-29
THYM	TF	EIF3A	TMF1	0.808747713	1.95E-29
THYM	TF	EIF3A	ZNF236	0.809532559	1.57E-29
THYM	TF	EIF3A	ZNF134	0.809604107	1.53E-29
THYM	TF	EIF3A	RREB1	0.810563552	1.17E-29
THYM	TF	EIF3A	ZNF641	0.815287739	2.98E-30
THYM	TF	EIF3A	SP4	0.816201117	2.28E-30
THYM	TF	EIF3A	NCOA2	0.818964563	1.00E-30
THYM	TF	EIF3A	RLF	0.81913926	9.53E-31
THYM	TF	EIF3A	ZNF432	0.819235873	9.26E-31
THYM	TF	EIF3A	ZNF420	0.819855211	7.68E-31
THYM	TF	EIF3A	ZNF623	0.820817046	5.74E-31
THYM	TF	EIF3A	ZBTB26	0.821139537	5.21E-31
THYM	TF	EIF3A	SP3	0.822878325	3.06E-31
THYM	TF	EIF3A	SP2	0.823780443	2.32E-31
THYM	TF	EIF3A	ZNF611	0.823870197	2.26E-31
THYM	TF	EIF3A	JRKL	0.825956791	1.18E-31
THYM	TF	EIF3A	ZNF426	0.826456398	1.01E-31
THYM	TF	EIF3A	ZNF468	0.830106106	3.16E-32
THYM	TF	EIF3A	ZFX	0.830632543	2.67E-32
THYM	TF	EIF3A	ZNF217	0.833213351	1.15E-32
THYM	TF	EIF3A	ZNF800	0.834036183	8.79E-33
THYM	TF	EIF3A	GLYR1	0.83654247	3.82E-33
THYM	TF	EIF3A	ZNF146	0.838471511	1.99E-33
THYM	TF	EIF3A	NFXL1	0.839671342	1.32E-33
THYM	TF	EIF3A	HIVEP1	0.849460161	4.10E-35
THYM	TF	EIF3A	GTF2I	0.852667819	1.24E-35
THYM	TF	EIF3A	ZNF689	0.858840201	1.16E-36
THYM	TF	EIF3A	ZFP91	0.861742405	3.64E-37
THYM	TF	EIF3A	ADNP	0.863153499	2.06E-37
THYM	TF	EIF3A	ZNF710	0.865701959	7.20E-38
THYM	TF	EIF3A	ATF1	0.868217146	2.51E-38
THYM	TF	EIF3A	REST	0.876646129	6.16E-40
THYM	TF	EIF3A	ATF2	0.877249752	4.68E-40
THYM	TF	EIF3A	ZBTB39	0.877329168	4.51E-40
THYM	TF	EIF3A	ZNF28	0.88211222	4.81E-41
THYM	TF	EIF3A	NR2C2	0.886904073	4.62E-42
THYM	TF	EIF3A	BPTF	0.88999906	9.61E-43
THYM	TF	EIF3A	ZNF813	0.892200058	3.06E-43
THYM	TF	EIF3A	ZNF430	0.905320937	1.89E-46
THYM	TF	EIF3A	ZNF281	0.906249008	1.08E-46
THYM	TSG	EIF3A	TP53BP1	0.80739474	2.86E-29
THYM	TSG	EIF3A	WHSC1L1	0.80760616	2.69E-29
THYM	TSG	EIF3A	ARID1A	0.809011024	1.81E-29
THYM	TSG	EIF3A	RBL1	0.809246161	1.70E-29
THYM	TSG	EIF3A	CDC73	0.809629202	1.52E-29
THYM	TSG	EIF3A	EAF1	0.809966906	1.38E-29
THYM	TSG	EIF3A	DIDO1	0.810334558	1.25E-29
THYM	TSG	EIF3A	TANK	0.811329769	9.39E-30
THYM	TSG	EIF3A	GORAB	0.811582405	8.73E-30
THYM	TSG	EIF3A	BRCA2	0.819096317	9.65E-31
THYM	TSG	EIF3A	RASSF3	0.819143815	9.51E-31
THYM	TSG	EIF3A	CUL2	0.827917161	6.36E-32
THYM	TSG	EIF3A	TP53BP2	0.833744324	9.68E-33
THYM	TSG	EIF3A	SIRT1	0.833925456	9.12E-33
THYM	TSG	EIF3A	NUP98	0.835616572	5.20E-33
THYM	TSG	EIF3A	USP12	0.838931135	1.70E-33
THYM	TSG	EIF3A	HACE1	0.847072007	9.78E-35
THYM	TSG	EIF3A	HIVEP1	0.849460161	4.10E-35
THYM	TSG	EIF3A	IGF2R	0.856018859	3.47E-36
THYM	TSG	EIF3A	PTPN11	0.860598791	5.76E-37
THYM	TSG	EIF3A	ANAPC1	0.874535314	1.60E-39
THYM	TSG	EIF3A	VHL	0.876545182	6.45E-40
THYM	TSG	EIF3A	BARD1	0.8781355	3.11E-40
THYM	TSG	EIF3A	SHPRH	0.886712706	5.08E-42
THYM	TSG	EIF3A	NR2C2	0.886904073	4.62E-42
UCEC	Cell metabolism gene	EIF3A	PAFAH1B2	0.802568282	1.59E-46
UCEC	Cell metabolism gene	EIF3A	GLUD2	0.815320222	4.11E-49
UCEC	CGC	EIF3A	PAFAH1B2	0.802568282	1.59E-46
UCEC	Epifactor	EIF3A	DDX21	0.863946635	3.36E-61
UCS	Cell metabolism gene	EIF3A	POLR1B	0.800860524	1.71E-28
UCS	Cell metabolism gene	EIF3A	B3GNT2	0.801411624	1.48E-28
UCS	Cell metabolism gene	EIF3A	GLS	0.802606989	1.07E-28
UCS	Cell metabolism gene	EIF3A	NCOA6	0.802879876	9.92E-29
UCS	Cell metabolism gene	EIF3A	SYNJ2	0.808836335	1.91E-29
UCS	Cell metabolism gene	EIF3A	IPMK	0.813766233	4.65E-30
UCS	Cell metabolism gene	EIF3A	MTM1	0.816914599	1.85E-30
UCS	Cell metabolism gene	EIF3A	NCOA2	0.818964563	1.00E-30
UCS	Cell metabolism gene	EIF3A	MED1	0.823959319	2.20E-31
UCS	Cell metabolism gene	EIF3A	MUT	0.829665176	3.64E-32
UCS	Cell metabolism gene	EIF3A	MAN2A1	0.83055986	2.73E-32
UCS	Cell metabolism gene	EIF3A	PIK3CA	0.832060877	1.68E-32
UCS	Cell metabolism gene	EIF3A	MED17	0.833461666	1.06E-32
UCS	Cell metabolism gene	EIF3A	PATL1	0.834716947	7.02E-33
UCS	Cell metabolism gene	EIF3A	UGCG	0.835328427	5.73E-33
UCS	Cell metabolism gene	EIF3A	SPTLC2	0.835620716	5.20E-33
UCS	Cell metabolism gene	EIF3A	NCOR1	0.838697498	1.84E-33
UCS	Cell metabolism gene	EIF3A	AASDHPPT	0.842741821	4.56E-34
UCS	Cell metabolism gene	EIF3A	CDK8	0.852267173	1.45E-35
UCS	Cell metabolism gene	EIF3A	ARFGEF2	0.855130375	4.89E-36
UCS	Cell metabolism gene	EIF3A	MANEA	0.857434096	2.01E-36
UCS	Cell metabolism gene	EIF3A	PAFAH1B2	0.857566194	1.91E-36
UCS	Cell metabolism gene	EIF3A	NEU3	0.860889982	5.13E-37
UCS	Cell metabolism gene	EIF3A	POLR2B	0.864571215	1.15E-37
UCS	Cell metabolism gene	EIF3A	RQCD1	0.869892386	1.22E-38
UCS	Cell metabolism gene	EIF3A	PIKFYVE	0.872005121	4.90E-39
UCS	Cell metabolism gene	EIF3A	UPF2	0.885345232	1.00E-41
UCS	Cell metabolism gene	EIF3A	POLR3A	0.887788621	2.96E-42
UCS	Cell metabolism gene	EIF3A	XRN2	0.889728484	1.10E-42
UCS	Cell metabolism gene	EIF3A	GLUD2	0.893192356	1.81E-43
UCS	Cell metabolism gene	EIF3A	NUP153	0.902867403	8.16E-46
UCS	CGC	EIF3A	HIP1	0.800193045	2.05E-28
UCS	CGC	EIF3A	ERCC4	0.801032323	1.64E-28
UCS	CGC	EIF3A	ARID1A	0.809011024	1.81E-29
UCS	CGC	EIF3A	CDC73	0.809629202	1.52E-29
UCS	CGC	EIF3A	WRN	0.81084763	1.08E-29
UCS	CGC	EIF3A	UBR5	0.813128403	5.59E-30
UCS	CGC	EIF3A	TRRAP	0.814054479	4.28E-30
UCS	CGC	EIF3A	ASXL2	0.818807192	1.05E-30
UCS	CGC	EIF3A	NCOA2	0.818964563	1.00E-30
UCS	CGC	EIF3A	BRCA2	0.819096317	9.65E-31
UCS	CGC	EIF3A	BCOR	0.824134985	2.08E-31
UCS	CGC	EIF3A	PIK3CA	0.832060877	1.68E-32
UCS	CGC	EIF3A	NUP98	0.835616572	5.20E-33
UCS	CGC	EIF3A	BRD4	0.838013685	2.32E-33
UCS	CGC	EIF3A	NCOR1	0.838697498	1.84E-33
UCS	CGC	EIF3A	ARID1B	0.83976285	1.28E-33
UCS	CGC	EIF3A	N4BP2	0.840394651	1.03E-33
UCS	CGC	EIF3A	PPM1D	0.843294379	3.76E-34
UCS	CGC	EIF3A	BIRC6	0.852806179	1.18E-35
UCS	CGC	EIF3A	PAFAH1B2	0.857566194	1.91E-36
UCS	CGC	EIF3A	PTPN11	0.860598791	5.76E-37
UCS	CGC	EIF3A	ATF1	0.868217146	2.51E-38
UCS	CGC	EIF3A	VHL	0.876545182	6.45E-40
UCS	CGC	EIF3A	STRN	0.876902054	5.48E-40
UCS	CGC	EIF3A	MLLT10	0.87698023	5.29E-40
UCS	CGC	EIF3A	BRD3	0.877236516	4.71E-40
UCS	CGC	EIF3A	BARD1	0.8781355	3.11E-40
UCS	CGC	EIF3A	FUBP1	0.906003044	1.25E-46
UCS	CGC	EIF3A	STAG1	0.908793985	2.23E-47
UCS	Epifactor	EIF3A	NCOA6	0.802879876	9.92E-29
UCS	Epifactor	EIF3A	TET3	0.804549882	6.28E-29
UCS	Epifactor	EIF3A	RSF1	0.805432123	4.93E-29
UCS	Epifactor	EIF3A	TP53BP1	0.80739474	2.86E-29
UCS	Epifactor	EIF3A	WHSC1L1	0.80760616	2.69E-29
UCS	Epifactor	EIF3A	WAC	0.807815578	2.54E-29
UCS	Epifactor	EIF3A	ARID1A	0.809011024	1.81E-29
UCS	Epifactor	EIF3A	CDC73	0.809629202	1.52E-29
UCS	Epifactor	EIF3A	CTR9	0.811736194	8.35E-30
UCS	Epifactor	EIF3A	MPHOSPH8	0.81293684	5.91E-30
UCS	Epifactor	EIF3A	TAF1	0.813085123	5.67E-30
UCS	Epifactor	EIF3A	UBR5	0.813128403	5.59E-30
UCS	Epifactor	EIF3A	TRRAP	0.814054479	4.28E-30
UCS	Epifactor	EIF3A	SMEK2	0.814965996	3.28E-30
UCS	Epifactor	EIF3A	ASXL2	0.818807192	1.05E-30
UCS	Epifactor	EIF3A	NCOA2	0.818964563	1.00E-30
UCS	Epifactor	EIF3A	BRCA2	0.819096317	9.65E-31
UCS	Epifactor	EIF3A	BCOR	0.824134985	2.08E-31
UCS	Epifactor	EIF3A	RBBP4	0.824181062	2.05E-31
UCS	Epifactor	EIF3A	CUL2	0.827917161	6.36E-32
UCS	Epifactor	EIF3A	ZNF217	0.833213351	1.15E-32
UCS	Epifactor	EIF3A	EPC2	0.833294213	1.12E-32
UCS	Epifactor	EIF3A	SIRT1	0.833925456	9.12E-33
UCS	Epifactor	EIF3A	GLYR1	0.83654247	3.82E-33
UCS	Epifactor	EIF3A	BRD4	0.838013685	2.32E-33
UCS	Epifactor	EIF3A	NCOR1	0.838697498	1.84E-33
UCS	Epifactor	EIF3A	USP12	0.838931135	1.70E-33
UCS	Epifactor	EIF3A	ARID1B	0.83976285	1.28E-33
UCS	Epifactor	EIF3A	TAF1L	0.842170456	5.57E-34
UCS	Epifactor	EIF3A	MAP3K7	0.846505906	1.20E-34
UCS	Epifactor	EIF3A	GTF2I	0.852667819	1.24E-35
UCS	Epifactor	EIF3A	JMJD1C	0.854524097	6.16E-36
UCS	Epifactor	EIF3A	BRPF3	0.857472117	1.98E-36
UCS	Epifactor	EIF3A	PHF8	0.858891608	1.13E-36
UCS	Epifactor	EIF3A	RNF168	0.861512118	4.00E-37
UCS	Epifactor	EIF3A	ADNP	0.863153499	2.06E-37
UCS	Epifactor	EIF3A	FAM175B	0.868620729	2.11E-38
UCS	Epifactor	EIF3A	PARG	0.86915052	1.68E-38
UCS	Epifactor	EIF3A	REST	0.876646129	6.16E-40
UCS	Epifactor	EIF3A	MLLT10	0.87698023	5.29E-40
UCS	Epifactor	EIF3A	SMARCAD1	0.877178783	4.83E-40
UCS	Epifactor	EIF3A	BRD3	0.877236516	4.71E-40
UCS	Epifactor	EIF3A	ATF2	0.877249752	4.68E-40
UCS	Epifactor	EIF3A	BARD1	0.8781355	3.11E-40
UCS	Epifactor	EIF3A	TAF2	0.879707885	1.50E-40
UCS	Epifactor	EIF3A	RBBP5	0.879789791	1.44E-40
UCS	Epifactor	EIF3A	SHPRH	0.886712706	5.08E-42
UCS	Epifactor	EIF3A	BPTF	0.88999906	9.61E-43
UCS	Epifactor	EIF3A	C11orf30	0.892165032	3.11E-43
UCS	Epifactor	EIF3A	EPC1	0.896042721	3.89E-44
UCS	Epifactor	EIF3A	ZRANB3	0.89969189	5.10E-45
UCS	Epifactor	EIF3A	TADA2A	0.902469941	1.03E-45
UCS	Epifactor	EIF3A	PPP4R2	0.905446672	1.75E-46
UCS	Epifactor	EIF3A	SMARCA5	0.905495688	1.70E-46
UCS	Epifactor	EIF3A	DDX21	0.915982613	2.02E-49
UCS	IUPHAR	EIF3A	GLS	0.802606989	1.07E-28
UCS	IUPHAR	EIF3A	SLC30A5	0.806468146	3.70E-29
UCS	IUPHAR	EIF3A	SYNJ2	0.808836335	1.91E-29
UCS	IUPHAR	EIF3A	SLC4A7	0.809944502	1.39E-29
UCS	IUPHAR	EIF3A	ATP13A3	0.810818441	1.09E-29
UCS	IUPHAR	EIF3A	SLC35A3	0.812475159	6.76E-30
UCS	IUPHAR	EIF3A	LMTK2	0.81253169	6.65E-30
UCS	IUPHAR	EIF3A	NPEPPS	0.812888689	6.00E-30
UCS	IUPHAR	EIF3A	SLC10A7	0.81289662	5.98E-30
UCS	IUPHAR	EIF3A	TAF1	0.813085123	5.67E-30
UCS	IUPHAR	EIF3A	TRRAP	0.814054479	4.28E-30
UCS	IUPHAR	EIF3A	NEK1	0.814909004	3.33E-30
UCS	IUPHAR	EIF3A	SLC35E3	0.815732008	2.62E-30
UCS	IUPHAR	EIF3A	NCOA2	0.818964563	1.00E-30
UCS	IUPHAR	EIF3A	SLC30A6	0.826111553	1.12E-31
UCS	IUPHAR	EIF3A	PDPK1	0.830426276	2.85E-32
UCS	IUPHAR	EIF3A	NEK7	0.831025048	2.35E-32
UCS	IUPHAR	EIF3A	PIK3CA	0.832060877	1.68E-32
UCS	IUPHAR	EIF3A	HIPK3	0.832890895	1.28E-32
UCS	IUPHAR	EIF3A	SIRT1	0.833925456	9.12E-33
UCS	IUPHAR	EIF3A	UGCG	0.835328427	5.73E-33
UCS	IUPHAR	EIF3A	SPTLC2	0.835620716	5.20E-33
UCS	IUPHAR	EIF3A	NEK4	0.837907751	2.41E-33
UCS	IUPHAR	EIF3A	BRD4	0.838013685	2.32E-33
UCS	IUPHAR	EIF3A	WNK1	0.840124439	1.13E-33
UCS	IUPHAR	EIF3A	TAF1L	0.842170456	5.57E-34
UCS	IUPHAR	EIF3A	PPM1D	0.843294379	3.76E-34
UCS	IUPHAR	EIF3A	SLC38A7	0.844707733	2.28E-34
UCS	IUPHAR	EIF3A	SLC25A24	0.844846676	2.17E-34
UCS	IUPHAR	EIF3A	MAP3K7	0.846505906	1.20E-34
UCS	IUPHAR	EIF3A	ADAM17	0.850540754	2.75E-35
UCS	IUPHAR	EIF3A	TNKS2	0.851965611	1.62E-35
UCS	IUPHAR	EIF3A	DPP8	0.852073866	1.56E-35
UCS	IUPHAR	EIF3A	CDK8	0.852267173	1.45E-35
UCS	IUPHAR	EIF3A	BIRC6	0.852806179	1.18E-35
UCS	IUPHAR	EIF3A	JMJD1C	0.854524097	6.16E-36
UCS	IUPHAR	EIF3A	BRPF3	0.857472117	1.98E-36
UCS	IUPHAR	EIF3A	PHF8	0.858891608	1.13E-36
UCS	IUPHAR	EIF3A	PIKFYVE	0.872005121	4.90E-39
UCS	IUPHAR	EIF3A	IDE	0.873238911	2.84E-39
UCS	IUPHAR	EIF3A	SLC25A40	0.87662977	6.21E-40
UCS	IUPHAR	EIF3A	BRD3	0.877236516	4.71E-40
UCS	IUPHAR	EIF3A	NR2C2	0.886904073	4.62E-42
UCS	IUPHAR	EIF3A	BPTF	0.88999906	9.61E-43
UCS	IUPHAR	EIF3A	SLK	0.899866207	4.62E-45
UCS	IUPHAR	EIF3A	SCYL2	0.901729392	1.58E-45
UCS	IUPHAR	EIF3A	ADAM10	0.913798753	8.80E-49
UCS	IUPHAR	EIF3A	MAPK8	0.914072427	7.33E-49
UCS	Kinase	EIF3A	LMTK2	0.81253169	6.65E-30
UCS	Kinase	EIF3A	TAF1	0.813085123	5.67E-30
UCS	Kinase	EIF3A	TRRAP	0.814054479	4.28E-30
UCS	Kinase	EIF3A	NEK1	0.814909004	3.33E-30
UCS	Kinase	EIF3A	PDPK1	0.830426276	2.85E-32
UCS	Kinase	EIF3A	NEK7	0.831025048	2.35E-32
UCS	Kinase	EIF3A	HIPK3	0.832890895	1.28E-32
UCS	Kinase	EIF3A	NEK4	0.837907751	2.41E-33
UCS	Kinase	EIF3A	BRD4	0.838013685	2.32E-33
UCS	Kinase	EIF3A	WNK1	0.840124439	1.13E-33
UCS	Kinase	EIF3A	TAF1L	0.842170456	5.57E-34
UCS	Kinase	EIF3A	MAP3K7	0.846505906	1.20E-34
UCS	Kinase	EIF3A	CDK8	0.852267173	1.45E-35
UCS	Kinase	EIF3A	BRD3	0.877236516	4.71E-40
UCS	Kinase	EIF3A	SLK	0.899866207	4.62E-45
UCS	Kinase	EIF3A	SCYL2	0.901729392	1.58E-45
UCS	Kinase	EIF3A	MAPK8	0.914072427	7.33E-49
UCS	TF	EIF3A	ZNF397	0.800155803	2.07E-28
UCS	TF	EIF3A	ZNF627	0.800984733	1.66E-28
UCS	TF	EIF3A	ZNF776	0.802617452	1.07E-28
UCS	TF	EIF3A	ELK3	0.80306744	9.43E-29
UCS	TF	EIF3A	TET3	0.804549882	6.28E-29
UCS	TF	EIF3A	ZNF407	0.805635067	4.66E-29
UCS	TF	EIF3A	KLF7	0.806491455	3.67E-29
UCS	TF	EIF3A	ZNF225	0.807411766	2.84E-29
UCS	TF	EIF3A	ZBTB10	0.807611536	2.69E-29
UCS	TF	EIF3A	TMF1	0.808747713	1.95E-29
UCS	TF	EIF3A	ZNF236	0.809532559	1.57E-29
UCS	TF	EIF3A	ZNF134	0.809604107	1.53E-29
UCS	TF	EIF3A	RREB1	0.810563552	1.17E-29
UCS	TF	EIF3A	ZNF641	0.815287739	2.98E-30
UCS	TF	EIF3A	SP4	0.816201117	2.28E-30
UCS	TF	EIF3A	NCOA2	0.818964563	1.00E-30
UCS	TF	EIF3A	RLF	0.81913926	9.53E-31
UCS	TF	EIF3A	ZNF432	0.819235873	9.26E-31
UCS	TF	EIF3A	ZNF420	0.819855211	7.68E-31
UCS	TF	EIF3A	ZNF623	0.820817046	5.74E-31
UCS	TF	EIF3A	ZBTB26	0.821139537	5.21E-31
UCS	TF	EIF3A	SP3	0.822878325	3.06E-31
UCS	TF	EIF3A	SP2	0.823780443	2.32E-31
UCS	TF	EIF3A	ZNF611	0.823870197	2.26E-31
UCS	TF	EIF3A	JRKL	0.825956791	1.18E-31
UCS	TF	EIF3A	ZNF426	0.826456398	1.01E-31
UCS	TF	EIF3A	ZNF468	0.830106106	3.16E-32
UCS	TF	EIF3A	ZFX	0.830632543	2.67E-32
UCS	TF	EIF3A	ZNF217	0.833213351	1.15E-32
UCS	TF	EIF3A	ZNF800	0.834036183	8.79E-33
UCS	TF	EIF3A	GLYR1	0.83654247	3.82E-33
UCS	TF	EIF3A	ZNF146	0.838471511	1.99E-33
UCS	TF	EIF3A	NFXL1	0.839671342	1.32E-33
UCS	TF	EIF3A	HIVEP1	0.849460161	4.10E-35
UCS	TF	EIF3A	GTF2I	0.852667819	1.24E-35
UCS	TF	EIF3A	ZNF689	0.858840201	1.16E-36
UCS	TF	EIF3A	ZFP91	0.861742405	3.64E-37
UCS	TF	EIF3A	ADNP	0.863153499	2.06E-37
UCS	TF	EIF3A	ZNF710	0.865701959	7.20E-38
UCS	TF	EIF3A	ATF1	0.868217146	2.51E-38
UCS	TF	EIF3A	REST	0.876646129	6.16E-40
UCS	TF	EIF3A	ATF2	0.877249752	4.68E-40
UCS	TF	EIF3A	ZBTB39	0.877329168	4.51E-40
UCS	TF	EIF3A	ZNF28	0.88211222	4.81E-41
UCS	TF	EIF3A	NR2C2	0.886904073	4.62E-42
UCS	TF	EIF3A	BPTF	0.88999906	9.61E-43
UCS	TF	EIF3A	ZNF813	0.892200058	3.06E-43
UCS	TF	EIF3A	ZNF430	0.905320937	1.89E-46
UCS	TF	EIF3A	ZNF281	0.906249008	1.08E-46
UCS	TSG	EIF3A	TP53BP1	0.80739474	2.86E-29
UCS	TSG	EIF3A	WHSC1L1	0.80760616	2.69E-29
UCS	TSG	EIF3A	ARID1A	0.809011024	1.81E-29
UCS	TSG	EIF3A	RBL1	0.809246161	1.70E-29
UCS	TSG	EIF3A	CDC73	0.809629202	1.52E-29
UCS	TSG	EIF3A	EAF1	0.809966906	1.38E-29
UCS	TSG	EIF3A	DIDO1	0.810334558	1.25E-29
UCS	TSG	EIF3A	TANK	0.811329769	9.39E-30
UCS	TSG	EIF3A	GORAB	0.811582405	8.73E-30
UCS	TSG	EIF3A	BRCA2	0.819096317	9.65E-31
UCS	TSG	EIF3A	RASSF3	0.819143815	9.51E-31
UCS	TSG	EIF3A	CUL2	0.827917161	6.36E-32
UCS	TSG	EIF3A	TP53BP2	0.833744324	9.68E-33
UCS	TSG	EIF3A	SIRT1	0.833925456	9.12E-33
UCS	TSG	EIF3A	NUP98	0.835616572	5.20E-33
UCS	TSG	EIF3A	USP12	0.838931135	1.70E-33
UCS	TSG	EIF3A	HACE1	0.847072007	9.78E-35
UCS	TSG	EIF3A	HIVEP1	0.849460161	4.10E-35
UCS	TSG	EIF3A	IGF2R	0.856018859	3.47E-36
UCS	TSG	EIF3A	PTPN11	0.860598791	5.76E-37
UCS	TSG	EIF3A	ANAPC1	0.874535314	1.60E-39
UCS	TSG	EIF3A	VHL	0.876545182	6.45E-40
UCS	TSG	EIF3A	BARD1	0.8781355	3.11E-40
UCS	TSG	EIF3A	SHPRH	0.886712706	5.08E-42
UCS	TSG	EIF3A	NR2C2	0.886904073	4.62E-42
UVM	Cell metabolism gene	EIF3A	AP3M1	0.803473218	3.01E-19
UVM	Cell metabolism gene	EIF3A	PIK3C3	0.819824095	1.42E-20
UVM	Cell metabolism gene	EIF3A	UPF2	0.821290801	1.06E-20
UVM	Cell metabolism gene	EIF3A	SMG1	0.822146717	8.96E-21
UVM	Cell metabolism gene	EIF3A	RANBP2	0.848471406	2.94E-23
UVM	CGC	EIF3A	IL6ST	0.802737121	3.43E-19
UVM	CGC	EIF3A	KDM5A	0.814268344	4.14E-20
UVM	CGC	EIF3A	USP8	0.82808224	2.69E-21
UVM	CGC	EIF3A	ATF1	0.832666108	1.03E-21
UVM	CGC	EIF3A	RANBP2	0.848471406	2.94E-23
UVM	Epifactor	EIF3A	CUL2	0.80124934	4.46E-19
UVM	Epifactor	EIF3A	REST	0.801459561	4.30E-19
UVM	Epifactor	EIF3A	NIPBL	0.802433033	3.62E-19
UVM	Epifactor	EIF3A	MPHOSPH8	0.804251538	2.62E-19
UVM	Epifactor	EIF3A	BRCC3	0.80563239	2.04E-19
UVM	Epifactor	EIF3A	C11orf30	0.806614816	1.71E-19
UVM	Epifactor	EIF3A	ASH1L	0.808668695	1.18E-19
UVM	Epifactor	EIF3A	USP12	0.809625118	9.87E-20
UVM	Epifactor	EIF3A	KDM5A	0.814268344	4.14E-20
UVM	Epifactor	EIF3A	EPC1	0.818639391	1.79E-20
UVM	Epifactor	EIF3A	TAF1	0.825190851	4.86E-21
UVM	Epifactor	EIF3A	DDX50	0.829532048	1.99E-21
UVM	Epifactor	EIF3A	INO80	0.83683345	4.18E-22
UVM	Epifactor	EIF3A	ZRANB3	0.841189792	1.59E-22
UVM	Epifactor	EIF3A	PARG	0.844523531	7.42E-23
UVM	Epifactor	EIF3A	WAC	0.867963679	2.02E-25
UVM	Epifactor	EIF3A	DDX21	0.872797937	5.18E-26
UVM	IUPHAR	EIF3A	TAOK3	0.801517559	4.25E-19
UVM	IUPHAR	EIF3A	IL6ST	0.802737121	3.43E-19
UVM	IUPHAR	EIF3A	ASH1L	0.808668695	1.18E-19
UVM	IUPHAR	EIF3A	HIPK3	0.812403891	5.88E-20
UVM	IUPHAR	EIF3A	KDM5A	0.814268344	4.14E-20
UVM	IUPHAR	EIF3A	SLC30A5	0.818529836	1.83E-20
UVM	IUPHAR	EIF3A	PIK3C3	0.819824095	1.42E-20
UVM	IUPHAR	EIF3A	SMG1	0.822146717	8.96E-21
UVM	IUPHAR	EIF3A	SCYL2	0.82432273	5.79E-21
UVM	IUPHAR	EIF3A	TAF1	0.825190851	4.86E-21
UVM	Kinase	EIF3A	TAOK3	0.801517559	4.25E-19
UVM	Kinase	EIF3A	HIPK3	0.812403891	5.88E-20
UVM	Kinase	EIF3A	SMG1	0.822146717	8.96E-21
UVM	Kinase	EIF3A	SCYL2	0.82432273	5.79E-21
UVM	Kinase	EIF3A	TAF1	0.825190851	4.86E-21
UVM	TF	EIF3A	REST	0.801459561	4.30E-19
UVM	TF	EIF3A	ZNF420	0.802743047	3.42E-19
UVM	TF	EIF3A	ASH1L	0.808668695	1.18E-19
UVM	TF	EIF3A	ZNF41	0.811740612	6.66E-20
UVM	TF	EIF3A	ZNF146	0.813445819	4.84E-20
UVM	TF	EIF3A	ZNF407	0.816293956	2.81E-20
UVM	TF	EIF3A	ZNF791	0.817866349	2.08E-20
UVM	TF	EIF3A	ATF1	0.832666108	1.03E-21
UVM	TSG	EIF3A	CUL2	0.80124934	4.46E-19
UVM	TSG	EIF3A	USP12	0.809625118	9.87E-20
UVM	TSG	EIF3A	KDM5A	0.814268344	4.14E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	EIF3A	EIF3K	-1.81556046390697	0.000109195709228516
LUAD	EIF3A	EIF3D	-2.4724631441106	0.000299564272708473
BRCA	EIF3A	EIF5	-1.16704316213885	0.00107943958337404
LIHC	EIF3A	EIF3C	-1.23074521883972	0.00126327311470459
LIHC	EIF3A	EIF2S3	-4.62530933210412	0.00154404530385922
LUAD	EIF3A	EIF3J	-1.1109238877878	0.00216965225011196
KIRP	EIF3A	EIF3G	-2.4178322962129	0.00471024587750435
LIHC	EIF3A	EIF3E	-5.1722332599854	0.00593802028362182
KICH	EIF3A	EIF3D	-5.64942867023017	0.0202749371528625
UCEC	EIF3A	EIF3G	-3.35078334696571	0.03125
BLCA	EIF3A	EIF3G	-3.07707559649091	0.0323410034179688
ESCA	EIF3A	EIF2S3	-1.31322237574718	0.0419921875
LUAD	EIF3A	EIF3B	-5.80435587546762	1.0542655358657e-09
KIRC	EIF3A	EIF3D	-2.33501876832058	1.16831478033445e-08
THCA	EIF3A	EIF3J	1.32428508175103	1.19078203681914e-07
BRCA	EIF3A	EIF3G	1.87948385011271	1.9107949115022e-06
KIRC	EIF3A	EIF3B	-1.56313263784517	2.35252849767166e-12
LIHC	EIF3A	EIF3D	-2.51854304632799	2.35319665208461e-06
KICH	EIF3A	EIF3J	2.09716749126717	3.19480895996094e-05
STAD	EIF3A	EIF3B	-4.7724660972007	3.25962901115418e-08
HNSC	EIF3A	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF3A	EIF3B	-2.7592297042974	4.6566128730774e-09
LIHC	EIF3A	EIF5	-2.12060405382854	4.66164898670786e-08
KIRC	EIF3A	EIF3E	-4.49824101219462	7.8509870430991e-09
BRCA	EIF3A	EIF3E	-1.48408348062463	9.51829316317813e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF3A

EIF1B, EIF4A2, EIF3L, EIF3E, EIF3H, EIF3I, EIF3F, EIF4A1, EIF3K, EIF3M, EIF3D, MCC, TFE3, EIF3B, EIF3G, EIF3J, EIF3C, EIF4G1, EIF4G2, EIF4B, USP3, WDR48, PIK3C2A, PRKAG2, UBA5, YWHAZ, tat, RNF139, CACNA1A, Eif3a, Itsn2, RAD21, CDK2, GRK5, EIF4H, RPLP1, NCL, NAP1L4, HNRNPF, MSMO1, MYH9, MRPL46, MYH11, TOMM40, TUBB6, SMURF1, DDX3X, FN1, VCAM1, UPF1, ITGA4, gag-pol, BBS1, BBS4, CD81, IGSF8, ICAM1, FBXO6, TARDBP, DYNC1I2, EIF3CL, RPS10, RPS12, RPS18, RPS20, RPS23, RPS26, RPS3, RPS3A, LARP1, NUDT21, RPS25, RPS9, YTHDF2, SHFM1, WWOX, LGR4, RIOK2, STAU1, WWP2, REL, TFIP11, OBSL1, CCDC8, EED, RNF2, BZW2, RSPH9, PAIP1, UNK, ABCF2, ATP6V0D1, NTRK1, KRAS, HERC2, SRPK2, AHSA1, KIF11, NPM1, RPL10, XRCC3, Eif3e, Eif3i, Rpl35, GAN, Ksr1, MEX3C, RNF126, U2AF2, FAU, ZNF746, GPBP1L1, CPNE2, GPBP1, UBC, MTNR1B, CYLD, DLD, DNM1L, PDHA1, SOD1, G3BP1, BRCA1, CFTR, ZNF598, PPM1D, PTPN3, PHACTR3, DUSP16, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, FAM188B, SPDL1, RIOK1, ESR2, HEXIM1, MEPCE, LARP7, RUNX1, RNF123, AGR2, RECQL4, MYC, KIAA1429, ATG16L1, TGFBR2, CHEK2, NR2C2, UBQLN2, EIF4E, GBF1, ATXN3, CD74, DDX60, P2RY6, MAB21L2, CDC14A, DUSP21, DUSP28, BIRC3, BRD7, CMTR1, PLEKHA4, MIB1, PINK1, YAP1, TFCP2, LINC01554, ZC3H18, PEBP1, RAB5A, GIMAP8, NLRP12, HNRNPU, ANKRD55, nsp1, ESR1, LAMTOR5, DUX4, CIT, ECT2, KIF14, KIF20A, AIM2, IFI16, MNDA, nsp2ab, LRRC59, NDN, BRD4, NUPR1, CIC, Apc2, RBM39, YWHAE, USP10, CUL4A, EIF4G3, EIF4EBP2, EIF4ENIF1, EIF4EBP1, ANGEL1, PARK2, UFL1, SERBP1, FZR1, FXR1, TSC1, WDR5, NUDCD2, NAA40, GIGYF1, CERS2, PLCD3, SQSTM1, SLFN11, KLF15, KLF16, KLF8,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF3A	chr10	120795626	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120797799	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120801663	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120801896	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF3A	chr10	120801908	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF3A	chr10	120802053	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF3A	chr10	120802157	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF3A	chr10	120810091	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120810098	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF3A	chr10	120820747	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120820799	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120820826	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120832573	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF3A	chr10	120833262	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF3A	chr10	120833280	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF3A	GBM	chr10	120801744	120801744	G	A	Missense_Mutation		9
EIF3A	GBM	chr10	120801756	120801756	G	C	Silent		8
EIF3A	BRCA	chr10	120795555	120795555	C	T	Missense_Mutation	p.R1382H	5
EIF3A	BLCA	chr10	120802195	120802195	C	G	Missense_Mutation	p.R946T	4
EIF3A	KIRC	chr10	120801712	120801712	C	T	Missense_Mutation	p.R1107Q	4
EIF3A	GBM	chr10	120801755	120801755	T	A	Missense_Mutation		4
EIF3A	ESCA	chr10	120830510	120830510	C	T	Missense_Mutation	p.R210H	3
EIF3A	BRCA	chr10	120797885	120797885	G	A	Missense_Mutation	p.S1198L	3
EIF3A	KIRC	chr10	120832959	120832959	G	A	Missense_Mutation	p.P124L	3
EIF3A	PAAD	chr10	120801997	120801997	G	A	Missense_Mutation	p.A1012V	3
EIF3A	LIHC	chr10	120803610	120803610	T	-	Frame_Shift_Del	p.K901fs	3
EIF3A	SKCM	chr10	120795706	120795706	G	A	Missense_Mutation	p.P1332S	3
EIF3A	COAD	chr10	120825029	120825029	C	T	Missense_Mutation	p.R335H	3
EIF3A	SKCM	chr10	120801536	120801536	G	A	Missense_Mutation	p.P1166S	3
EIF3A	READ	chr10	120810137	120810137	C	T	Missense_Mutation	p.R790Q	3
EIF3A	SKCM	chr10	120802039	120802039	G	A	Missense_Mutation	p.P998L	3
EIF3A	UCS	chr10	120816463	120816463	C	T	Silent	p.K689K	3
EIF3A	SKCM	chr10	120809324	120809324	G	A	Missense_Mutation	p.L883F	3
EIF3A	UCEC	chr10	120795673	120795673	G	A	Nonsense_Mutation	p.R1343*	3
EIF3A	ESCA	chr10	120795774	120795774	G	T	Missense_Mutation	p.S1309Y	3
EIF3A	PAAD	chr10	120830529	120830529	G	A	Missense_Mutation	p.H204Y	3
EIF3A	BLCA	chr10	120802040	120802040	G	A	Missense_Mutation	p.P998S	3
EIF3A	UCEC	chr10	120830448	120830448	C	T	Missense_Mutation	p.E231K	3
EIF3A	ESCA	chr10	120817707	120817707	C	T	Missense_Mutation	p.E580K	3
EIF3A	LIHC	chr10	120833382	120833382	T	-	Frame_Shift_Del	p.K39fs	3
EIF3A	SKCM	chr10	120824973	120824973	G	A	Missense_Mutation	p.R354C	3
EIF3A	TGCT	chr10	120820788	120820788	T	C	Missense_Mutation	p.N392S	2
EIF3A	KIRC	chr10	120796677	120796677	G	A	Silent	p.D1291D	2
EIF3A	UCEC	chr10	120801663	120801663	G	A	Silent	p.A1123	2
EIF3A	BLCA	chr10	120801833	120801833	G	A	Missense_Mutation	p.R1067W	2
EIF3A	SKCM	chr10	120801566	120801566	G	A	Missense_Mutation	p.R1156W	2
EIF3A	UCEC	chr10	120810755	120810755	A	C	Missense_Mutation	p.L759V	2
EIF3A	COAD	chr10	120832428	120832428	C	T	Missense_Mutation	p.R172H	2
EIF3A	HNSC	chr10	120809363	120809363	G	A	Missense_Mutation	p.R870W	2
EIF3A	BLCA	chr10	120829139	120829139	G	C	Missense_Mutation		2
EIF3A	UCEC	chr10	120801732	120801732	C	T	Silent	p.R1100	2
EIF3A	LGG	chr10	120796752	120796752	G	A	Silent		2
EIF3A	BLCA	chr10	120817659	120817659	G	A	Nonsense_Mutation	p.Q596*	2
EIF3A	COAD	chr10	120809334	120809334	G	A	Silent	p.G879G	2
EIF3A	SARC	chr10	120824963	120824963	G	T	Missense_Mutation		2
EIF3A	STAD	chr10	120810145	120810145	C	G	Missense_Mutation	p.R787S	2
EIF3A	CESC	chr10	120829034	120829034	G	T	Missense_Mutation		2
EIF3A	UCEC	chr10	120817632	120817632	G	A	Missense_Mutation	p.R605W	2
EIF3A	HNSC	chr10	120820798	120820798	C	A	Missense_Mutation	p.D389Y	2
EIF3A	KIRP	chr10	120817717	120817717	C	A	Missense_Mutation		2
EIF3A	ESCA	chr10	120830510	120830510	C	T	Missense_Mutation		2
EIF3A	UCEC	chr10	120802000	120802000	T	C	Missense_Mutation	p.H1011R	2
EIF3A	SKCM	chr10	120816534	120816534	G	A	Missense_Mutation	p.P666S	2
EIF3A	STAD	chr10	120802173	120802173	G	A	Silent	p.D953D	2
EIF3A	SKCM	chr10	120818836	120818836	G	A	Missense_Mutation	p.P506L	2
EIF3A	UCEC	chr10	120817760	120817760	C	T	Missense_Mutation	p.R562Q	2
EIF3A	HNSC	chr10	120809438	120809438	G	A	Nonsense_Mutation	p.Q845*	2
EIF3A	LUAD	chr10	120802184	120802184	G	A	Missense_Mutation	p.L950F	2
EIF3A	ESCA	chr10	120817707	120817707	C	T	Missense_Mutation		2
EIF3A	LGG	chr10	120802275	120802275	T	G	Missense_Mutation	p.R919S	2
EIF3A	LIHC	chr10	120801825	120801825	G	-	Frame_Shift_Del	p.P1069fs	2
EIF3A	SKCM	chr10	120817749	120817749	G	A	Nonsense_Mutation	p.Q566*	2
EIF3A	UCEC	chr10	120802002	120802002	A	G	Silent	p.R1010	2
EIF3A	SKCM	chr10	120801560	120801560	G	A	Missense_Mutation	p.P1158S	2
EIF3A	STAD	chr10	120825078	120825078	A	G	Missense_Mutation	p.S319P	2
EIF3A	CESC	chr10	120810137	120810137	C	T	Missense_Mutation		2
EIF3A	SKCM	chr10	120818837	120818837	G	A	Missense_Mutation	p.P506S	2
EIF3A	UCEC	chr10	120819163	120819163	A	G	Missense_Mutation	p.F465S	2
EIF3A	HNSC	chr10	120801689	120801689	C	T	Missense_Mutation	p.D1115N	2
EIF3A	ESCA	chr10	120795774	120795774	G	T	Missense_Mutation		2
EIF3A	LGG	chr10	120796752	120796752	G	A	Silent	p.D1266D	2
EIF3A	LIHC	chr10	120803575	120803575	G	-	Frame_Shift_Del	p.P914fs	2
EIF3A	UCEC	chr10	120802004	120802004	G	A	Missense_Mutation	p.R1010C	2
EIF3A	STAD	chr10	120796733	120796733	G	A	Missense_Mutation	p.R1273C	2
EIF3A	CESC	chr10	120797792	120797792	C	G	Missense_Mutation		2
EIF3A	SKCM	chr10	120832525	120832525	G	A	Missense_Mutation	p.R140C	2
EIF3A	UCEC	chr10	120830573	120830573	G	A	Missense_Mutation	p.T189M	2
EIF3A	HNSC	chr10	120802159	120802159	G	T	Missense_Mutation	p.P958H	2
EIF3A	LIHC	chr10	120801558	120801558	G	A	Silent		2
EIF3A	STAD	chr10	120810113	120810113	C	T	Missense_Mutation	p.R798H	2
EIF3A	UCEC	chr10	120802033	120802033	C	T	Missense_Mutation	p.R1000Q	2
EIF3A	UCEC	chr10	120840142	120840142	T	C	Missense_Mutation	p.N16S	2
EIF3A	UCEC	chr10	120795559	120795559	G	A	Nonsense_Mutation	p.R1381*	2
EIF3A	LIHC	chr10	120809425	120809425	T	-	Frame_Shift_Del	p.K850fs	2
EIF3A	STAD	chr10	120801843	120801843	A	G	Silent		2
EIF3A	STAD	chr10	120810115	120810115	C	T	Silent	p.Q797Q	2
EIF3A	UCEC	chr10	120802165	120802165	C	T	Missense_Mutation	p.R956Q	2
EIF3A	UCEC	chr10	120795600	120795600	C	T	Missense_Mutation	p.R1367H	2
EIF3A	LIHC	chr10	120824927	120824927	C	-	Frame_Shift_Del	p.G369fs	2
EIF3A	PAAD	chr10	120830529	120830529	G	A	Missense_Mutation		2
EIF3A	BLCA	chr10	120809348	120809348	C	G	Missense_Mutation	p.E875Q	2
EIF3A	STAD	chr10	120818780	120818780	C	A	Missense_Mutation		2
EIF3A	STAD	chr10	120802226	120802226	G	A	Missense_Mutation	p.R936W	2
EIF3A	UCEC	chr10	120802173	120802173	G	A	Silent	p.D953	2
EIF3A	LIHC	chr10	120819149	120819149	C	T	Missense_Mutation	p.A470T	2
EIF3A	UCEC	chr10	120795664	120795664	C	A	Nonsense_Mutation	p.E1346*	2
EIF3A	LIHC	chr10	120830450	120830450	A	-	Frame_Shift_Del	p.L230fs	2
EIF3A	BLCA	chr10	120795652	120795652	C	T	Missense_Mutation	p.E1350K	2
EIF3A	STAD	chr10	120801843	120801843	A	G	Silent	p.A1063A	2
EIF3A	STAD	chr10	120825026	120825026	G	A	Missense_Mutation	p.T336M	2
EIF3A	UCEC	chr10	120802268	120802268	C	A	Nonsense_Mutation	p.E922*	2
EIF3A	LIHC	chr10	120819149	120819149	C	T	Missense_Mutation		2
EIF3A	KIRC	chr10	120801706	120801706	G	A	Missense_Mutation	p.P1109L	2
EIF3A	UCEC	chr10	120795684	120795684	C	T	Missense_Mutation	p.R1339Q	2
EIF3A	LIHC	chr10	120833029	120833029	T	-	Frame_Shift_Del	p.T101fs	2
EIF3A	STAD	chr10	120801864	120801864	C	T	Silent	p.E1056E	2
EIF3A	UCEC	chr10	120810135	120810135	A	G	Silent	p.L791	2
EIF3A	TGCT	chr10	120820788	120820788	T	C	Missense_Mutation		2
EIF3A	UCEC	chr10	120801538	120801538	C	A	Missense_Mutation	p.R1165I	2
EIF3A	BLCA	chr10	120801973	120801973	C	T	Missense_Mutation	p.R1020Q	2
EIF3A	STAD	chr10	120801952	120801952	C	T	Missense_Mutation	p.G1027E	2
EIF3A	UCEC	chr10	120810725	120810725	G	A	Nonsense_Mutation	p.Q769*	2
EIF3A	LIHC	chr10	120801729	120801729	T	A	Silent		2
EIF3A	LUAD	chr10	120810820	120810820	T	A	Missense_Mutation	p.Q737L	2
EIF3A	LIHC	chr10	120801773	120801773	G	T	Silent	p.R1087R	1
EIF3A	LUSC	chr10	120801982	120801982	G	T	Missense_Mutation	p.P1017Q	1
EIF3A	BLCA	chr10	120820298	120820298	G	T	Missense_Mutation		1
EIF3A	CESC	chr10	120797792	120797792	C	G	Missense_Mutation	p.R1229T	1
EIF3A	SKCM	chr10	120801559	120801559	G	A	Missense_Mutation	p.P1158L	1
EIF3A	UCEC	chr10	120810117	120810117	G	T	Missense_Mutation	p.Q797K	1
EIF3A	HNSC	chr10	120809363	120809363	G	A	Missense_Mutation		1
EIF3A	LGG	chr10	120802275	120802275	T	G	Missense_Mutation		1
EIF3A	LIHC	chr10	120795620	120795620	T	-	Frame_Shift_Del	p.K1360fs	1
EIF3A	PAAD	chr10	120830492	120830492	G	A	Missense_Mutation	p.T216M	1
EIF3A	COAD	chr10	120802153	120802153	C	T	Missense_Mutation	p.R960H	1
EIF3A	SARC	chr10	120816346	120816346	G	T	Missense_Mutation		1
EIF3A	STAD	chr10	120796691	120796691	G	A	Nonsense_Mutation	p.R1287X	1
EIF3A	STAD	chr10	120818780	120818780	C	A	Missense_Mutation	p.A525S	1
EIF3A	LIHC	chr10	120818744	120818744	T	C	Missense_Mutation		1
EIF3A	LUAD	chr10	120832466	120832466	C	A	Missense_Mutation	p.Q159H	1
EIF3A	BLCA	chr10	120809348	120809348	C	G	Missense_Mutation		1
EIF3A	LIHC	chr10	120801558	120801558	G	A	Silent	p.P1158P	1
EIF3A	LUSC	chr10	120795713	120795713	T	A	Silent	p.R1329R	1
EIF3A	CHOL	chr10	120820340	120820340	C	A	Missense_Mutation		1
EIF3A	SKCM	chr10	120797766	120797766	G	A	Missense_Mutation	p.R1238C	1
EIF3A	THCA	chr10	120829168	120829168	T	C	Splice_Site		1
EIF3A	UCEC	chr10	120801732	120801732	C	T	Silent	p.R1100R	1
EIF3A	ESCA	chr10	120801701	120801701	G	T	Silent	p.R1111	1
EIF3A	HNSC	chr10	120820798	120820798	C	A	Missense_Mutation		1
EIF3A	LIHC	chr10	120797935	120797935	T	-	Frame_Shift_Del	p.K1181fs	1
EIF3A	SKCM	chr10	120820272	120820272	G	T	Missense_Mutation	p.R438S	1
EIF3A	STAD	chr10	120810064	120810066	CTC	-	In_Frame_Del	p.E814del	1
EIF3A	COAD	chr10	120832524	120832524	C	A	Missense_Mutation	p.R140L	1
EIF3A	LIHC	chr10	120796778	120796778	T	C	Missense_Mutation		1
EIF3A	LUAD	chr10	120797844	120797844	C	A	Missense_Mutation	p.D1212Y	1
EIF3A	BLCA	chr10	120795652	120795652	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120795646	120795647	-	T	Frame_Shift_Ins	p.E1352fs	1
EIF3A	LUSC	chr10	120801779	120801779	C	A	Missense_Mutation	p.D1085Y	1
EIF3A	BLCA	chr10	120833321	120833321	C	T	Missense_Mutation		1
EIF3A	CHOL	chr10	120820340	120820340	C	A	Missense_Mutation	p.R415M	1
EIF3A	SKCM	chr10	120810750	120810750	G	A	Silent	p.F760F	1
EIF3A	UCEC	chr10	120810041	120810041	A	G	Missense_Mutation	p.M822T	1
EIF3A	HNSC	chr10	120801689	120801689	C	T	Missense_Mutation		1
EIF3A	LGG	chr10	120801913	120801913	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120817547	120817547	T	-	Frame_Shift_Del	p.K634fs	1
EIF3A	PAAD	chr10	120801889	120801889	G	A	Missense_Mutation	p.P1048L	1
EIF3A	BLCA	chr10	120803574	120803574	C	T	Silent	p.P913P	1
EIF3A	COAD	chr10	120810775	120810775	C	T	Missense_Mutation	p.R752Q	1
EIF3A	BLCA	chr10	120802040	120802040	G	A	Missense_Mutation		1
EIF3A	CESC	chr10	120801804	120801804	A	G	Silent		1
EIF3A	STAD	chr10	120810101	120810101	C	T	Missense_Mutation	p.R802H	1
EIF3A	THCA	chr10	120801645	120801645	G	T	Silent		1
EIF3A	COAD	chr10	120795718	120795718	G	T	Missense_Mutation	p.R1328S	1
EIF3A	LIHC	chr10	120797831	120797831	C	T	Missense_Mutation		1
EIF3A	LUSC	chr10	120832423	120832423	A	G	Missense_Mutation	p.Y174H	1
EIF3A	BLCA	chr10	120801902	120801902	C	T	Missense_Mutation		1
EIF3A	COAD	chr10	120795647	120795647	T	-	Frame_Shift_Del	p.E1352fs	1
EIF3A	UCEC	chr10	120795768	120795768	C	G	Missense_Mutation	p.R1311T	1
EIF3A	HNSC	chr10	120802159	120802159	G	T	Missense_Mutation		1
EIF3A	LGG	chr10	120802156	120802156	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120833056	120833056	C	-	Frame_Shift_Del	p.A92fs	1
EIF3A	BLCA	chr10	120796680	120796680	T	C	Silent	p.R1290R	1
EIF3A	COAD	chr10	120816474	120816474	C	T	Missense_Mutation	p.E686K	1
EIF3A	BLCA	chr10	120801973	120801973	C	T	Missense_Mutation		1
EIF3A	STAD	chr10	120818859	120818859	A	G	Silent	p.N498N	1
EIF3A	THCA	chr10	120797843	120797843	T	A	Missense_Mutation		1
EIF3A	COAD	chr10	120801576	120801576	A	G	Silent	p.A1152A	1
EIF3A	LIHC	chr10	120832562	120832562	A	G	Silent		1
EIF3A	LUAD	chr10	120801812	120801812	C	A	Missense_Mutation	p.D1074Y	1
EIF3A	LUSC	chr10	120802059	120802059	G	A	Silent	p.N991N	1
EIF3A	BLCA	chr10	120796685	120796685	G	C	Missense_Mutation		1
EIF3A	COAD	chr10	120796639	120796639	C	T	Missense_Mutation	p.R1304H	1
EIF3A	PRAD	chr10	120802285	120802285	C	A	Splice_Site		1
EIF3A	SKCM	chr10	120802106	120802106	T	C	Missense_Mutation	p.R976G	1
EIF3A	UCEC	chr10	120809471	120809471	G	T	Silent	p.R834R	1
EIF3A	HNSC	chr10	120829137	120829137	G	A	Silent		1
EIF3A	LGG	chr10	120818756	120818756	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120833289	120833289	C	-	Frame_Shift_Del	p.G70fs	1
EIF3A	BLCA	chr10	120824916	120824916	C	T	Missense_Mutation	p.D373N	1
EIF3A	COAD	chr10	120820795	120820795	G	T	Missense_Mutation	p.L390I	1
EIF3A	SKCM	chr10	120801507	120801507	T	C	Silent	p.P1175P	1
EIF3A	BLCA	chr10	120801833	120801833	G	A	Missense_Mutation		1
EIF3A	STAD	chr10	120802094	120802094	G	A	Missense_Mutation	p.R980C	1
EIF3A	THCA	chr10	120797843	120797843	T	A	Missense_Mutation	p.D1212V	1
EIF3A	COAD	chr10	120810158	120810158	A	G	Missense_Mutation	p.L783S	1
EIF3A	LUAD	chr10	120830458	120830458	G	A	Silent	p.S227S	1
EIF3A	ESCA	chr10	120801701	120801701	G	T	Silent	p.R1111R	1
EIF3A	LGG	chr10	120801913	120801913	C	T	Missense_Mutation	p.R1040H	1
EIF3A	LUSC	chr10	120802129	120802129	G	C	Missense_Mutation	p.P968R	1
EIF3A	BLCA	chr10	120796783	120796783	G	C	Missense_Mutation	p.S1256C	1
EIF3A	COAD	chr10	120796668	120796668	G	A	Silent	p.D1294D	1
EIF3A	READ	chr10	120796727	120796727	G	T	Missense_Mutation	p.R1275S	1
EIF3A	STAD	chr10	120810064	120810066	CTC	-	In_Frame_Del		1
EIF3A	UCEC	chr10	120810135	120810135	A	G	Silent	p.L791L	1
EIF3A	HNSC	chr10	120797938	120797938	C	T	Silent		1
EIF3A	LGG	chr10	120830555	120830555	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120820333	120820333	T	C	Silent		1
EIF3A	LIHC	chr10	120801917	120801917	T	-	Frame_Shift_Del	p.R1040fs	1
EIF3A	BLCA	chr10	120830469	120830469	C	G	Missense_Mutation	p.E224Q	1
EIF3A	LIHC	chr10	120832562	120832562	A	G	Silent	p.V127V	1
EIF3A	LUAD	chr10	120833071	120833071	C	G	Missense_Mutation	p.E87Q	1
EIF3A	BLCA	chr10	120803574	120803574	C	T	Silent		1
EIF3A	CESC	chr10	120796821	120796821	C	C	Silent		1
EIF3A	SKCM	chr10	120796713	120796713	G	A	Silent	p.D1279D	1
EIF3A	STAD	chr10	120796691	120796691	G	A	Nonsense_Mutation	p.R1287*	1
EIF3A	THYM	chr10	120797885	120797885	G	A	Missense_Mutation		1
EIF3A	COAD	chr10	120824934	120824934	G	A	Nonsense_Mutation	p.R367X	1
EIF3A	HNSC	chr10	120817671	120817671	C	T	Missense_Mutation	p.E592K	1
EIF3A	GBM	chr10	120801816	120801816	C	G	Silent	p.G1072G	1
EIF3A	LGG	chr10	120832515	120832515	C	T	Missense_Mutation	p.R143K	1
EIF3A	LUSC	chr10	120797901	120797901	G	T	Silent	p.R1193R	1
EIF3A	BLCA	chr10	120802240	120802240	C	G	Missense_Mutation	p.R931T	1
EIF3A	COAD	chr10	120797824	120797826	CTC	-	In_Frame_Del	p.1218_1219del	1
EIF3A	READ	chr10	120801592	120801592	C	T	Missense_Mutation	p.R1147H	1
EIF3A	HNSC	chr10	120809388	120809388	C	T	Silent		1
EIF3A	LGG	chr10	120832515	120832515	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120833288	120833288	A	G	Silent		1
EIF3A	LIHC	chr10	120818874	120818874	A	-	Frame_Shift_Del	p.F493fs	1
EIF3A	COAD	chr10	120829112	120829112	G	T	Missense_Mutation	p.P266T	1
EIF3A	LIHC	chr10	120828985	120828985	T	C	Missense_Mutation	p.K308R	1
EIF3A	LUAD	chr10	120801569	120801569	C	T	Missense_Mutation	p.D1155N	1
EIF3A	BLCA	chr10	120796680	120796680	T	C	Silent		1
EIF3A	CESC	chr10	120819416	120819416	C	G	RNA	NULL	1
EIF3A	SKCM	chr10	120817683	120817683	G	A	Nonsense_Mutation	p.Q588*	1
EIF3A	STAD	chr10	120795603	120795603	C	T	Missense_Mutation	p.R1366H	1
EIF3A	THYM	chr10	120810733	120810733	G	T	Missense_Mutation		1
EIF3A	UCS	chr10	120816463	120816463	C	T	Silent		1
EIF3A	DLBC	chr10	120824953	120824953	A	C	Silent	p.G360G	1
EIF3A	HNSC	chr10	120829139	120829139	G	A	Missense_Mutation	p.H257Y	1
EIF3A	LGG	chr10	120819204	120819204	C	T	Silent	p.E451E	1
EIF3A	COAD	chr10	120801804	120801804	A	G	Silent	p.D1076D	1
EIF3A	HNSC	chr10	120817671	120817671	C	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120820272	120820272	G	A	Missense_Mutation		1
EIF3A	LIHC	chr10	120818890	120818890	G	T	Missense_Mutation		1
EIF3A	LIHC	chr10	120824942	120824942	G	-	Frame_Shift_Del	p.P365fs	1
EIF3A	BLCA	chr10	120829139	120829139	G	C	Missense_Mutation	p.H257D	1
EIF3A	LUSC	chr10	120810778	120810778	G	T	Nonsense_Mutation	p.S751*	1
EIF3A	BLCA	chr10	120824916	120824916	C	T	Missense_Mutation		1
EIF3A	CESC	chr10	120829034	120829034	G	T	Missense_Mutation	p.H292N	1
EIF3A	SKCM	chr10	120801507	120801507	T	C	Splice_Site	p.P1175_splice	1
EIF3A	STAD	chr10	120797783	120797784	TC	-	Frame_Shift_Del	p.D1232fs	1
EIF3A	THYM	chr10	120810733	120810733	G	T	Missense_Mutation	p.A766D	1
EIF3A	DLBC	chr10	120819176	120819187	AAGGAACCAAAG	-	In_Frame_Del	p.457_461del	1
EIF3A	HNSC	chr10	120829137	120829137	G	A	Silent	p.H257H	1
EIF3A	LGG	chr10	120818756	120818756	C	T	Missense_Mutation	p.A533T	1
EIF3A	PAAD	chr10	120801593	120801593	G	T	Missense_Mutation		1
EIF3A	COAD	chr10	120801850	120801850	C	T	Missense_Mutation	p.R1061H	1
EIF3A	READ	chr10	120796666	120796666	C	T	Missense_Mutation	p.R1295Q	1
EIF3A	HNSC	chr10	120840149	120840149	G	A	Missense_Mutation	p.R14C	1
EIF3A	LIHC	chr10	120833382	120833382	T	-	Frame_Shift_Del		1
EIF3A	LIHC	chr10	120824980	120824980	T	-	Frame_Shift_Del	p.K351fs	1
EIF3A	BLCA	chr10	120830514	120830514	G	A	Nonsense_Mutation	p.Q209*	1
EIF3A	LIHC	chr10	120801517	120801517	A	T	Nonsense_Mutation	p.L1172X	1
EIF3A	LUSC	chr10	120801831	120801831	C	A	Silent	p.R1067R	1
EIF3A	BLCA	chr10	120802195	120802195	C	G	Missense_Mutation		1
EIF3A	CESC	chr10	120818980	120818980	C	T	RNA	NULL	1
EIF3A	SKCM	chr10	120816325	120816325	G	A	Missense_Mutation	p.P708L	1
EIF3A	STAD	chr10	120797765	120797765	C	T	Missense_Mutation		1
EIF3A	GBM	chr10	120816470	120816470	C	T	Missense_Mutation		1
EIF3A	LGG	chr10	120830555	120830555	C	T	Missense_Mutation	p.R195H	1
EIF3A	COAD	chr10	120801851	120801851	G	A	Missense_Mutation	p.R1061C	1
EIF3A	READ	chr10	120801943	120801943	C	T	Missense_Mutation	p.R1030Q	1
EIF3A	SKCM	chr10	120817749	120817749	G	A	Nonsense_Mutation	p.Q566X	1
EIF3A	STAD	chr10	120797783	120797784	TC	-	Frame_Shift_Del	p.1232_1232del	1
EIF3A	HNSC	chr10	120809388	120809388	C	T	Silent	p.R861R	1
EIF3A	LIHC	chr10	120828985	120828985	T	C	Missense_Mutation		1
EIF3A	LUAD	chr10	120819115	120819115	T	A	Splice_Site	p.Q481_splice	1
EIF3A	BLCA	chr10	120796783	120796783	G	C	Missense_Mutation		1
EIF3A	BLCA	chr10	120796685	120796685	G	C	Missense_Mutation	p.L1289V	1
EIF3A	LIHC	chr10	120801729	120801729	T	A	Silent	p.R1101R	1
EIF3A	LUSC	chr10	120801850	120801850	C	A	Missense_Mutation	p.R1061L	1
EIF3A	BLCA	chr10	120801862	120801862	C	A	Missense_Mutation		1
EIF3A	CESC	chr10	120796821	120796821	C	T	Silent	p.R1243	1
EIF3A	SKCM	chr10	120803648	120803648	G	C	Missense_Mutation	p.R889G	1
EIF3A	LGG	chr10	120802156	120802156	C	T	Missense_Mutation	p.R959Q	1
EIF3A	PAAD	chr10	120818809	120818809	G	A	Missense_Mutation	p.P515L	1
EIF3A	COAD	chr10	120801892	120801892	C	T	Missense_Mutation	p.G1047E	1
EIF3A	READ	chr10	120810097	120810097	C	T	Silent	p.R803R	1
EIF3A	STAD	chr10	120797765	120797765	C	T	Missense_Mutation	p.R1238H	1
EIF3A	HNSC	chr10	120797938	120797938	C	T	Silent	p.E1180E	1
EIF3A	BLCA	chr10	120802240	120802240	C	G	Missense_Mutation		1

Copy number variation (CNV) of EIF3A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF3A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100213	N/A	BE841770	ATP2C2	chr16	84432115	-	EIF3A	chr10	120817711	+
100213	BRCA	TCGA-D8-A1JK-01A	CACUL1	chr10	120488807	-	EIF3A	chr10	120818909	-
99400	N/A	AI423400	EIF3A	chr10	120814090	+	CORO1C	chr12	109039027	+
100213	N/A	AW606930	EIF3A	chr10	120802277	+	EIF3A	chr10	120796662	+
100213	N/A	AW607722	EIF3A	chr10	120802185	+	EIF3A	chr10	120802111	-
103166	N/A	BI491212	EIF3A	chr10	120834131	-	EWSR1	chr22	29696509	-
89816	BRCA	TCGA-OL-A5D7-01A	EIF3A	chr10	120797912	-	GRK5	chr10	121060194	-
25775	Non-Cancer	ERR188295	EIF3A	chr10	120828958	-	LINC00867	chr10	120117284	+
92440	N/A	BF752470	EIF3A	chr10	120816354	+	LRRFIP1	chr2	238672005	-
61553	N/A	AX395943	EIF3A	chr10	120795531	+	MAOA	chrX	43605687	+
86055	N/A	BC020285	EIF3A	chr10	120794560	-	PCYOX1	chr2	70499240	-
101008	ESCA	TCGA-IG-A3YA	EIF3A	chr10	120810032	-	PSME1	chr14	24606529	+
100319	N/A	CF122514	EIF3A	chr10	120793182	-	PTPRS	chr19	5202417	+
25775	N/A	BM771430	EIF3A	chr10	120840140	-	SFXN4	chr10	120914690	-
67463	N/A	AI207430	EIF3A	chr10	120801566	-	SLCO1B1	chr12	21294366	+
101219	N/A	BE797876	EIF3A	chr10	120801969	-	SMARCC1	chr3	47680270	-
89276	HNSC	TCGA-P3-A6T8	EIF3A	chr10	120809312	-	TBC1D1	chr4	38091552	+
89276	HNSC	TCGA-P3-A6T8-01A	EIF3A	chr10	120809313	-	TBC1D1	chr4	38091553	+
31913	STAD	TCGA-BR-8078-01A	EIF3A	chr10	120840140	-	UBR3	chr2	170871791	+
103068	Non-Cancer	TCGA-06-0678-11A	EIF3A	chr10	120802166	-	UNC13A	chr19	17732679	-
103068	Non-Cancer	TCGA-06-AABW-11A	EIF3A	chr10	120802163	-	UNC13A	chr19	17732676	-
100213	N/A	AU117098	FAM217B	chr20	58522021	+	EIF3A	chr10	120801572	-
100213	N/A	AI420562	MRPS18B	chr6	30593886	-	EIF3A	chr10	120808602	+
100213	N/A	DA942713	PSMD6	chr3	64008050	-	EIF3A	chr10	120809487	-
100213	N/A	AW501580	STAG2	chrX	123205097	+	EIF3A	chr10	120829131	-
100236	BLCA	TCGA-FD-A5BY	YWHAZ	chr8	101937143	-	EIF3A	chr10	120796821	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	EIF3A	0.000592223003729502	0.016
KIRP	EIF3A	0.00218712600235881	0.057
SKCM	EIF3A	0.0278565104176628	0.7
GBM	EIF3A	0.0439218448654405	1
LUSC	EIF3A	0.0471101775166737	1
LUAD	EIF3A	1.87352882516516e-05	0.00052

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	EIF3A	1.5373857922256e-05	0.00051
BRCA	EIF3A	0.0159554565405845	0.51

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0376358	Malignant neoplasm of prostate	1	CTD_human