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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRRF (NCBI Gene ID:92399)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRRF
	Gene ID: 92399
	Gene Symbol	MRRF
	Gene ID	92399
	Gene Name	mitochondrial ribosome recycling factor
	Synonyms	MRFF\|MTRRF\|RRF
	Cytomap	9q33.2
	Type of Gene	protein-coding
	Description	ribosome-recycling factor, mitochondrialribosome-releasing factor, mitochondrial
	Modification date	20200313
	UniProtAcc	Q96E11

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MRRF	GO:0032790	ribosome disassembly	19716793

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRRF	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRRF[title] AND translation [title] AND human.'

Gene	Title	PMID
MRRF	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000344641	125033142	125033354	5CDS-5UTR
ENST00000344641	125042721	125042877	In-frame
ENST00000344641	125047447	125047566	Frame-shift
ENST00000344641	125054027	125054119	Frame-shift
ENST00000344641	125075505	125075665	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000344641	125042721	125042877	1964	496	651	262	61	113

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	MRRF	1.86992130954506	0.0014527440071106
LIHC	MRRF	-1.19805818879659	0.0305924082275009
PRAD	MRRF	-1.56810957454655	2.74398347191128e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PCPG	MRRF	0.106245962	0.025971636

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRRF (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	MRRF	PMPCA	0.803350973	9.62E-22
THYM	Cell metabolism gene	MRRF	NUPL2	0.836015153	4.56E-33
THYM	Epifactor	MRRF	DNAJC2	0.810895213	1.06E-29
UCS	Cell metabolism gene	MRRF	NUPL2	0.836015153	4.56E-33
UCS	Epifactor	MRRF	DNAJC2	0.810895213	1.06E-29
UVM	Cell metabolism gene	MRRF	TIMM9	0.808685798	1.17E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	MRRF	MRPL20	1.48585631024503	0.000111704804180407
KICH	MRRF	MRPL9	1.16888038960038	0.000120222568511963
LUAD	MRRF	MRPL20	-3.00071204707904	0.000452706327224566
BRCA	MRRF	MRPL20	-1.74379528461375	0.000756034430433012
KIRP	MRRF	GFM1	-3.60557651795202	0.00154796987771988
KIRP	MRRF	MRPL19	-1.9689242575519	0.00179363833740354
BLCA	MRRF	MRPL27	-4.19270554058168	0.00202178955078125
STAD	MRRF	MRPS16	-1.64208084987431	0.00239070039242506
KICH	MRRF	GFM1	1.05246565332639	0.00378090143203735
PRAD	MRRF	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRRF	MRPS16	-2.01564621821803	0.00518989327406416
KICH	MRRF	MRPL19	-2.18550705564541	0.00672554969787598
PRAD	MRRF	ICT1	-1.54848444909352	0.00907723161841939
STAD	MRRF	MRPL9	-1.54523483458273	0.0118026207201183
LIHC	MRRF	MRPL20	-1.08735154161025	0.0158079482509981
CHOL	MRRF	MRPL19	-2.09295650388558	0.0390625
BRCA	MRRF	MRPL27	-1.5584165725499	1.16393956539382e-08
LUSC	MRRF	MRPL21	-4.98277643789037	1.45947399043856e-08
THCA	MRRF	MRPS10	1.33413691764991	1.55171507174296e-05
LUSC	MRRF	MRPS9	-3.60637641031661	1.82498668910368e-07
LUAD	MRRF	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRRF	ICT1	-4.17488220449664	2.73719348917167e-14
LUAD	MRRF	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRRF	MRPL27	-1.81809468729316	3.90393047420304e-06
LUAD	MRRF	GFM1	-2.84901818322678	4.2869535120076e-07
LUAD	MRRF	MRPL21	-1.86897497221853	6.16191557420719e-07
LUSC	MRRF	ICT1	-3.23093376049456	6.60526357089358e-07
BRCA	MRRF	GFM1	1.76831243345242	7.05963288731276e-10
BRCA	MRRF	MRPL21	-1.5345447607194	7.40794680786486e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRRF

ICT1, APP, CDV3, MRPL53, RPS19, NDUFA7, SARNP, TSFM, PPIF, SLIRP, PPIB, NDUFA2, RBMS1, SRPRB, SCP2, HCCS, MRRFP1, DBT, MMAB, NFS1, LYRM7, IBA57, MED4, BANP, MKNK2, ANAPC15, TUBA1C, FBXO18, ARX, SKA1, Evpl, Nek2, Cenph, Cbx7, Pdlim5, Tipin, Cdc26, Mis12, Kif22, Haus1, Cep44, CT55, EFTUD2, ATG16L1, SYP, WIPI2, CMTM5, ZNF408, FAM9B, AGTRAP, FHL3, KRT40, nsp13, nsp3, nsp9, ORF8, KIF14, AUH, MDH2, AARS2, ACAD9, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALYREF, ARGLU1, ATP5B, ATP5C1, ATP5D, ATPIF1, ATP5J2-PTCD1, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCS1L, BRIX1, C17orf80, CARS2, CDK5RAP1, CLPX, COX5A, CS, DAP3, DDX18, DDX28, DDX50, DDX54, DHTKD1, DHX30, DLAT, DLST, EARS2, EBNA1BP2, ECHS1, ECSIT, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FASTKD5, FLAD1, GADD45GIP1, GARS, GATB, GATC, GCDH, GFM1, GLS, GLUD1, GRSF1, GTPBP10, GTPBP3, GTPBP6, GUF1, HADH, HADHA, HARS2, HINT2, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPDL, HNRNPK, HNRNPL, HNRNPR, HSD17B10, HSPA9, HSPD1, IARS2, IDH3A, IVD, KIAA0391, LARS2, LETM1, LONP1, LRPPRC, LUC7L, LUC7L2, LYRM4, MALSU1, ME2, METTL15, RNMTL1, MRPL1, MRPL10, MRPL12, MRPL13, MRPL15, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL32, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL52, MRPL54, MRPL55, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, MTHFD1L, MTIF2, MTPAP, MTRF1L, NDUFA12, NDUFA5, NDUFA6, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NIFK, NIPSNAP1, NME4, NNT, NUBPL, OAT, OGDH, PDE12, PDHA1, PDHB, PDHX, PDK1, PDK3, PDPR, PHB, PMPCA, PNPT1, POLDIP2, POLG, POLRMT, PREPL, PRPF4B, PTCD3, PUS1, PYCR1, PYCR2, WIBG, QRSL1, RBFA, RBM28, RBMX, WBSCR16, RPL36, RSL1D1, RTN4IP1, SHMT2, SLC30A9, SRSF4, STOML2, SUCLA2, SUPV3L1, SYNCRIP, TACO1, TARS2, TEFM, TFAM, THEM4, THG1L, TIMM44, TRMT10C, TRMT11, TRMT61B, TRUB2, C10orf2, U2AF2, VARS2, VWA8, WARS2, YARS2, CLPP, UCHL1, NR3C1, SOCS6, ZNF501, MTIF3, EFNB2, NUDT13, FTSJ2, FGFR1OP2, AHR, ZNF8, NAT1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRRF	chr9	125075600	A	G	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRRF	KIRC	chr9	125033141	125033141	A	T	Splice_Site		3
MRRF	LIHC	chr9	125054104	125054104	G	-	Frame_Shift_Del	p.R179fs	2
MRRF	SKCM	chr9	125084878	125084878	C	T	Silent	p.T257T	2
MRRF	SKCM	chr9	125075623	125075623	G	A	Silent	p.K223K	2
MRRF	HNSC	chr9	125084837	125084837	G	A	Missense_Mutation	p.D244N	2
MRRF	LUAD	chr9	125075536	125075536	G	T	Silent	p.V194V	2
MRRF	SKCM	chr9	125042722	125042722	C	T	Splice_Site	p.A62_splice	2
MRRF	HNSC	chr9	125042818	125042818	C	T	Missense_Mutation	p.S94F	2
MRRF	ESCA	chr9	125047552	125047552	G	A	Missense_Mutation	p.A149T	2
MRRF	LUSC	chr9	125033303	125033303	A	G	Missense_Mutation	p.M45V	1
MRRF	ESCA	chr9	125047541	125047541	T	C	Missense_Mutation		1
MRRF	STAD	chr9	125033202	125033202	T	C	Missense_Mutation	p.V11A	1
MRRF	LIHC	chr9	125042730	125042730	A	-	Frame_Shift_Del	p.K65fs	1
MRRF	OV	chr9	125075605	125075605	C	G	Missense_Mutation	p.N217K	1
MRRF	HNSC	chr9	125084837	125084837	G	A	Missense_Mutation		1
MRRF	LIHC	chr9	125047494	125047494	T	-	Frame_Shift_Del	p.A129fs	1
MRRF	OV	chr9	125033218	125033218	C	T	Silent	p.R16	1
MRRF	HNSC	chr9	125042818	125042818	C	T	Missense_Mutation		1
MRRF	LIHC	chr9	125075615	125075615	A	-	Frame_Shift_Del	p.K221fs	1
MRRF	BLCA	chr9	125054065	125054065	G	T	Missense_Mutation		1
MRRF	PAAD	chr9	125042786	125042786	C	A	Silent		1
MRRF	HNSC	chr9	125047560	125047560	C	T	Silent		1
MRRF	LIHC	chr9	125047451	125047451	C	-	Frame_Shift_Del	p.S115fs	1
MRRF	BLCA	chr9	125042729	125042729	G	C	Silent		1
MRRF	SARC	chr9	125048163	125048163	C	T	RNA	NULL	1
MRRF	HNSC	chr9	125042832	125042832	C	G	Missense_Mutation		1
MRRF	LUAD	chr9	125042807	125042807	A	T	Missense_Mutation	p.E90D	1
MRRF	BLCA	chr9	125042729	125042729	G	C	Silent	p.G64G	1
MRRF	HNSC	chr9	125042832	125042832	C	G	Missense_Mutation	p.L99V	1
MRRF	LUAD	chr9	125047485	125047485	G	T	Silent	p.G126G	1
MRRF	CESC	chr9	125075632	125075632	C	T	Silent		1
MRRF	LUAD	chr9	125042860	125042860	A	G	Missense_Mutation	p.N108S	1
MRRF	COAD	chr9	125042842	125042842	A	C	Missense_Mutation	p.N102T	1
MRRF	SKCM	chr9	125042722	125042722	C	T	Missense_Mutation	p.A62V	1
MRRF	HNSC	chr9	125047560	125047560	C	T	Silent	p.F151F	1
MRRF	ESCA	chr9	125084867	125084867	G	A	Nonsense_Mutation	p.W200*	1
MRRF	LUSC	chr9	125047469	125047469	T	C	Missense_Mutation	p.V121A	1
MRRF	ESCA	chr9	125047541	125047541	T	C	Missense_Mutation	p.L145S	1
MRRF	SKCM	chr9	125054115	125054115	C	T	Missense_Mutation	p.P183S	1
MRRF	LUSC	chr9	125054075	125054075	G	C	Silent	p.L169L	1
MRRF	STAD	chr9	125033141	125033141	A	T	Splice_Site	.	1

Copy number variation (CNV) of MRRF
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRRF
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94882	STAD	TCGA-EQ-A4SO-01A	CDC14B	chr9	99381501	-	MRRF	chr9	125075506	+
94882	N/A	BM972978	MGEA5	chr10	103547843	-	MRRF	chr9	125093607	-
100049	N/A	BG030962	MRRF	chr9	125085310	+	DIAPH3	chr13	60469285	+
85579	STAD	TCGA-CG-4436-01A	MRRF	chr9	125075665	+	GLIS3	chr9	3937189	-
73210	LUSC	TCGA-66-2754-01A	MRRF	chr9	125054119	-	KIAA0368	chr9	114206774	-
95148	BLCA	TCGA-DK-A3X1-01A	MRRF	chr9	125027217	+	NDUFA8	chr9	124906657	-
95595	SARC	TCGA-DX-A8BV-01A	MRRF	chr9	125027217	+	NR4A1	chr12	52448111	+
90011	COAD	TCGA-DM-A28A-01A	MRRF	chr9	125054119	+	TTLL11	chr9	124633027	-
94882	BRCA	TCGA-E2-A15E-06A	RC3H2	chr9	125652591	-	MRRF	chr9	125033143	+
94889	Non-Cancer	TCGA-HU-A4GC-11A	TTBK2	chr15	43212636	-	MRRF	chr9	125075506	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRRF	0.00147403583670778	0.041
TGCT	MRRF	0.00690306132089501	0.19
THCA	MRRF	0.0141606101425267	0.37
BRCA	MRRF	0.0376241179995533	0.94

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	MRRF	0.0244094451202235	0.71
LUSC	MRRF	0.000573537263680879	0.019
KICH	MRRF	0.044034233458587	1
PRAD	MRRF	0.00671363923281181	0.21
PAAD	MRRF	0.00764307713933483	0.24
OV	MRRF	0.0302527725705535	0.85
CESC	MRRF	0.012426527385324	0.37
THYM	MRRF	0.0468019940683807	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source