About FusionBase* FusionBase aims to serve as the base camp for understanding DNA breakage and coded structural variants, annotating the potential function of fusion genes/proteins, developing therapeutics targeting human fusion genes/proteins, clinical assessment of fusion genes/proteins, and distributing knowledge of fusion genes/proteins in diverse aspects including biology, biochemistry, pharmacology, and biomedical information. From the DNA breakpoint information, until we identify fusion-specific targeting therapeutics, we will continue to study this field with our knowledge and experiences with omnidirectional bioinformatics studies and serve diverse biology research fields.
News
*03/19/2025 - Corrected an error of the fusion mRNA/protein sequence length.
*02/12/2025 - These we are working on developing FusionGDB3. It will have up-to-date fusion gene breakpoints with more diverse functional annotation.
* 02/12/2025 - We release FusionPub: Therapeutic Landscape of Human Fusion Gene. Try to search your fusion gene to know all previous studies on targeting your fusion gene.
* 07/11/2024 - We provide 'Gene assessment score in pan-cancer fusion genes' information in the Download page of FusionGDB2. This file provides the individual human genes' potential impact assessment in pan-cancer fusion genes with our made scoreing methods.
* 07/11/2024 - We start to use new FusionGDB ID system for FusionGDB 2.0. The ID format is 'hg' + 5'-gene's NCBI gene ID + 'tg'+ 3'-gene's NCI gene ID. For example, the new FusionGDB ID of 'BCR-ABL1' is 'hg613tg25'. We also show all fusion gene information of the searched fusion gene considering all gene synonyms for each annotation category.
* 06/26/2024 - We moved our web server to the Cloudflare WAF system. It affects the loading time of our web pages. We will try to fix this issue. Please understand the situation.
* 04/30/2024 - We are making a new FusionGDB ID system from FusionGDB 2.0. All annotations are the same, but the ID will be different. It will be updated soon.
* 03/24/2022 - We have finished adding the curated fusion gene information (ChimerKB4) and following annotations into FusionGDB 2.0.
*02/12/2025 - These we are working on developing FusionGDB3. It will have up-to-date fusion gene breakpoints with more diverse functional annotation.
* 02/12/2025 - We release FusionPub: Therapeutic Landscape of Human Fusion Gene. Try to search your fusion gene to know all previous studies on targeting your fusion gene.
* 07/11/2024 - We provide 'Gene assessment score in pan-cancer fusion genes' information in the Download page of FusionGDB2. This file provides the individual human genes' potential impact assessment in pan-cancer fusion genes with our made scoreing methods.
* 07/11/2024 - We start to use new FusionGDB ID system for FusionGDB 2.0. The ID format is 'hg' + 5'-gene's NCBI gene ID + 'tg'+ 3'-gene's NCI gene ID. For example, the new FusionGDB ID of 'BCR-ABL1' is 'hg613tg25'. We also show all fusion gene information of the searched fusion gene considering all gene synonyms for each annotation category.
* 06/26/2024 - We moved our web server to the Cloudflare WAF system. It affects the loading time of our web pages. We will try to fix this issue. Please understand the situation.
* 04/30/2024 - We are making a new FusionGDB ID system from FusionGDB 2.0. All annotations are the same, but the ID will be different. It will be updated soon.
* 03/24/2022 - We have finished adding the curated fusion gene information (ChimerKB4) and following annotations into FusionGDB 2.0.
Resources for Precision Medicine of Fusion GenesChimerDB 2.0 : a knowledgebase for fusion genes updated
FusionGDB (1.0, 2.0, 3.0): Functional Annotation of Human Fusion Genes
FusionPDB (1.0, 2.0): Resource of the Fusion Protein 3D Structures
Models for Fusion Gene Features, ImpactsFusionAI: Predicting Fusion Breakpoint From DNA Sequence With Deep Learning
FusionAI protocol
Fusion gene & MMEJ
FusionNW: Clinical Impact Assessment of Kinases in Pan-Cancer Fusion Gene Network
Multimodal Functional Annotation of Fusion Genes/ProteinsFGviewer: Online Visualization Tool for Functional Features of Human Fusion Genes
Predict fusion protein 3D structure: Artificial Intelligence in Fusion Protein Three-Dimensional Structure Prediction
Novel fusion discoveryFusionScan: Accurate Prediction of Fusion Genes from RNA-Seq Data
ALK-PTPN3 from human non-small cell lung carcinoma cell line
VAMP2-NRG1, a Novel Oncogenic Driver of Non–Small-Cell Lung Adenocarcinoma
Frequent CTLA4-CD28 In Diverse Types Of T Cell Lymphoma
Publication: Fusion Gene Publications
Targeting Fusion GenesFusionTarget: Computational framework for drug repurposing against modeled fusion protein structures from genomic breakpoints
KinaseFusionDB: Integrative Knowledge of Kinase Fusion Proteins in Multi-Scales
FusionNeoAntigen: Resource of Fusion Gene-Specific Neoantigens
FusionPub: Therapeutic Landscape of Human Fusion Genes
Consults/Collaborators* Dr. Sanghyuk Lee, Professor, Department of Life Sciences, Ewha Womans University, Seoul, South Korea
* Dr. Wenshe Liu, Professor, Department of Chemistry, Texas A&M University, College Station, TX, USA
* Dr. Yoon-La Choi, Associate Professor of Pathology, Sungkyunkwan University School of Medicine, Samsung Medical center, Seoul, South Korea
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