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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DHPS (NCBI Gene ID:1725)

Gene Summary

Gene Summary

Gene Information	Gene Name: DHPS
	Gene ID: 1725
	Gene Symbol	DHPS
	Gene ID	1725
	Gene Name	deoxyhypusine synthase
	Synonyms	DHS\|DS\|MIG13\|NEDSSWI
	Cytomap	19p13.13
	Type of Gene	protein-coding
	Description	deoxyhypusine synthasemigration-inducing gene 13
	Modification date	20200327
	UniProtAcc	P49366

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DHPS	GO:0008216	spermidine metabolic process	23525104
Hgene	DHPS	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	23525104

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DHPS	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DHPS[title] AND translation [title] AND human.'

Gene	Title	PMID
DHPS	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000210060	12786830	12786956	In-frame
ENST00000210060	12787921	12788025	Frame-shift
ENST00000210060	12790270	12790357	In-frame
ENST00000210060	12790614	12790736	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000210060	12786830	12786956	1380	1025	1150	369	296	338
ENST00000210060	12790270	12790357	1380	728	814	369	197	226

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P49366	296	338	1	369	Chain	ID=PRO_0000134469;Note=Deoxyhypusine synthase
P49366	197	226	1	369	Chain	ID=PRO_0000134469;Note=Deoxyhypusine synthase
P49366	296	338	308	309	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9493264;Dbxref=PMID:9493264
P49366	296	338	314	316	Region	Note=Spermidine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	296	338	323	329	Region	Note=Spermidine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	296	338	329	329	Active site	Note=Nucleophile;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9405486;Dbxref=PMID:9405486
P49366	296	338	262	308	Alternative sequence	ID=VSP_001351;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8615810;Dbxref=PMID:8615810
P49366	296	338	305	305	Mutagenesis	Note=Strongly reduced NAD binding. No effect on enzyme activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11311149;Dbxref=PMID:11311149
P49366	296	338	313	313	Mutagenesis	Note=Strongly reduced NAD binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11311149;Dbxref=PMID:11311149
P49366	296	338	316	316	Mutagenesis	Note=Reduces spermidine binding by 98%25. Loss of covalent intermediate formation and deoxyhypusine synthesis. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11311149;Dbxref=PMID:11311149
P49366	296	338	317	317	Mutagenesis	Note=Strongly reduced NAD binding. No effect on enzyme activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11311149;Dbxref=PMID:11311149
P49366	296	338	323	323	Mutagenesis	Note=Reduces spermidine binding by 98%25. Strongly reduced formation of covalent intermediate. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11311149;Dbxref=PMID:11311149
P49366	296	338	327	327	Mutagenesis	Note=Reduces spermidine binding by 98%25. Loss of covalent intermediate formation and deoxyhypusine synthesis. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11311149;Dbxref=PMID:11311149
P49366	296	338	329	329	Mutagenesis	Note=Loss of covalent intermediate formation and deoxyhypusine synthesis. K->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9405486;Dbxref=PMID:9405486
P49366	197	226	199	199	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	197	226	199	199	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	197	226	220	220	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	197	226	220	220	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	296	338	296	297	Sequence conflict	Note=MR->SG;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	296	338	311	311	Sequence conflict	Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305
P49366	197	226	203	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1RLZ
P49366	197	226	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1RLZ
P49366	296	338	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1RLZ
P49366	296	338	299	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1RLZ
P49366	296	338	321	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1RLZ
P49366	296	338	337	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1RLZ

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	DHPS	-2.2143641551526	0.00180184141035168
BRCA	DHPS	-1.35684185337444	1.3885583420074e-06
PRAD	DHPS	1.82553075697225	4.6388445697259e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SARC	DHPS	0.400695589	0.006847481

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DHPS (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	DHPS	GALK1	0.808601291	3.62E-12
TGCT	TF	DHPS	THAP8	0.833224975	1.81E-41
THCA	TSG	DHPS	AIP	0.800603418	6.82E-129
THYM	Cell metabolism gene	DHPS	UROD	0.800228685	2.03E-28
THYM	Cell metabolism gene	DHPS	INPP5K	0.802889944	9.90E-29
THYM	Cell metabolism gene	DHPS	TOMM22	0.804302667	6.73E-29
THYM	Cell metabolism gene	DHPS	PSMB2	0.806133719	4.06E-29
THYM	Cell metabolism gene	DHPS	SNRPE	0.809467532	1.59E-29
THYM	Cell metabolism gene	DHPS	SNRPD3	0.809534889	1.56E-29
THYM	Cell metabolism gene	DHPS	AAAS	0.80992629	1.40E-29
THYM	Cell metabolism gene	DHPS	PSME1	0.811532262	8.86E-30
THYM	Cell metabolism gene	DHPS	PSMD8	0.812222167	7.27E-30
THYM	Cell metabolism gene	DHPS	ANP32A	0.813801875	4.60E-30
THYM	Cell metabolism gene	DHPS	ACTB	0.813859161	4.53E-30
THYM	Cell metabolism gene	DHPS	NOP56	0.814630634	3.62E-30
THYM	Cell metabolism gene	DHPS	SNRPF	0.816397681	2.15E-30
THYM	Cell metabolism gene	DHPS	PSMB6	0.816618302	2.02E-30
THYM	Cell metabolism gene	DHPS	MED18	0.817812788	1.42E-30
THYM	Cell metabolism gene	DHPS	TIMM50	0.818809864	1.05E-30
THYM	Cell metabolism gene	DHPS	POLD1	0.818991642	9.96E-31
THYM	Cell metabolism gene	DHPS	OAZ1	0.819477077	8.61E-31
THYM	Cell metabolism gene	DHPS	NT5M	0.819625684	8.23E-31
THYM	Cell metabolism gene	DHPS	SLC27A5	0.820043862	7.26E-31
THYM	Cell metabolism gene	DHPS	TOMM40	0.822190537	3.78E-31
THYM	Cell metabolism gene	DHPS	MVD	0.82293193	3.01E-31
THYM	Cell metabolism gene	DHPS	POLR2J	0.824446445	1.89E-31
THYM	Cell metabolism gene	DHPS	FPGS	0.829289049	4.11E-32
THYM	Cell metabolism gene	DHPS	GCDH	0.829669805	3.64E-32
THYM	Cell metabolism gene	DHPS	TXN	0.829982366	3.29E-32
THYM	Cell metabolism gene	DHPS	SEC61B	0.830627648	2.67E-32
THYM	Cell metabolism gene	DHPS	SEC61G	0.830985678	2.38E-32
THYM	Cell metabolism gene	DHPS	TIMM8B	0.835210095	5.96E-33
THYM	Cell metabolism gene	DHPS	APRT	0.83687289	3.42E-33
THYM	Cell metabolism gene	DHPS	PHKG2	0.845046095	2.02E-34
THYM	Cell metabolism gene	DHPS	PGP	0.845156968	1.94E-34
THYM	Cell metabolism gene	DHPS	TIMM13	0.84555343	1.69E-34
THYM	Cell metabolism gene	DHPS	ZNRD1	0.84954096	3.98E-35
THYM	Cell metabolism gene	DHPS	POLR3K	0.850427306	2.87E-35
THYM	Cell metabolism gene	DHPS	APOA1	0.850945413	2.37E-35
THYM	Cell metabolism gene	DHPS	DUT	0.851977124	1.61E-35
THYM	Cell metabolism gene	DHPS	PSMA5	0.853884226	7.86E-36
THYM	Cell metabolism gene	DHPS	GUK1	0.854142524	7.13E-36
THYM	Cell metabolism gene	DHPS	TIMM17B	0.854547493	6.11E-36
THYM	Cell metabolism gene	DHPS	PSMA4	0.855623176	4.05E-36
THYM	Cell metabolism gene	DHPS	PSMB10	0.856010669	3.49E-36
THYM	Cell metabolism gene	DHPS	MTMR14	0.856354286	3.05E-36
THYM	Cell metabolism gene	DHPS	SNRPD1	0.860201049	6.75E-37
THYM	Cell metabolism gene	DHPS	DGUOK	0.861430141	4.13E-37
THYM	Cell metabolism gene	DHPS	EBP	0.861537716	3.95E-37
THYM	Cell metabolism gene	DHPS	POLD2	0.861594072	3.87E-37
THYM	Cell metabolism gene	DHPS	POLA2	0.862804743	2.37E-37
THYM	Cell metabolism gene	DHPS	LSM2	0.86764539	3.19E-38
THYM	Cell metabolism gene	DHPS	PSMB7	0.868184227	2.54E-38
THYM	Cell metabolism gene	DHPS	LSM5	0.868839426	1.92E-38
THYM	Cell metabolism gene	DHPS	PSMA6	0.869798214	1.28E-38
THYM	Cell metabolism gene	DHPS	PSMB3	0.87262453	3.73E-39
THYM	Cell metabolism gene	DHPS	LSM3	0.879874318	1.39E-40
THYM	Cell metabolism gene	DHPS	DTYMK	0.882929222	3.25E-41
THYM	Cell metabolism gene	DHPS	ACOT8	0.887133617	4.12E-42
THYM	Cell metabolism gene	DHPS	LSM4	0.892346994	2.83E-43
THYM	Cell metabolism gene	DHPS	SNRPB	0.892806729	2.22E-43
THYM	Cell metabolism gene	DHPS	SNRPD2	0.893285235	1.72E-43
THYM	Cell metabolism gene	DHPS	PAFAH1B3	0.895256947	5.97E-44
THYM	Cell metabolism gene	DHPS	PSMD13	0.900671621	2.92E-45
THYM	Cell metabolism gene	DHPS	PSMC3	0.902376528	1.09E-45
THYM	Cell metabolism gene	DHPS	GALK1	0.916398706	1.52E-49
THYM	CGC	DHPS	RECQL4	0.813066052	5.70E-30
THYM	CGC	DHPS	POLD1	0.818991642	9.96E-31
THYM	CGC	DHPS	BCL2L12	0.822156006	3.82E-31
THYM	CGC	DHPS	RBM10	0.833359769	1.10E-32
THYM	CGC	DHPS	BAX	0.86296675	2.22E-37
THYM	CGC	DHPS	SDHAF2	0.885020708	1.17E-41
THYM	CGC	DHPS	TFPT	0.897123645	2.15E-44
THYM	Epifactor	DHPS	CDK9	0.801918479	1.29E-28
THYM	Epifactor	DHPS	CDK5	0.803557104	8.25E-29
THYM	Epifactor	DHPS	CCDC101	0.803637202	8.07E-29
THYM	Epifactor	DHPS	SUV420H2	0.805991732	4.22E-29
THYM	Epifactor	DHPS	PKN1	0.807432172	2.83E-29
THYM	Epifactor	DHPS	HIST1H3C	0.809244967	1.70E-29
THYM	Epifactor	DHPS	ZGPAT	0.812620309	6.48E-30
THYM	Epifactor	DHPS	ANP32A	0.813801875	4.60E-30
THYM	Epifactor	DHPS	ACTB	0.813859161	4.53E-30
THYM	Epifactor	DHPS	HIST1H3F	0.814931367	3.31E-30
THYM	Epifactor	DHPS	H1FX	0.81826161	1.24E-30
THYM	Epifactor	DHPS	INO80E	0.818899432	1.02E-30
THYM	Epifactor	DHPS	RBX1	0.819538983	8.45E-31
THYM	Epifactor	DHPS	HIST1H2BH	0.820183583	6.96E-31
THYM	Epifactor	DHPS	MAZ	0.826098637	1.13E-31
THYM	Epifactor	DHPS	PAF1	0.826451916	1.01E-31
THYM	Epifactor	DHPS	SIRT6	0.826560667	9.76E-32
THYM	Epifactor	DHPS	ZNHIT1	0.828663104	5.02E-32
THYM	Epifactor	DHPS	MCRS1	0.829476098	3.87E-32
THYM	Epifactor	DHPS	HMGN2	0.829712183	3.59E-32
THYM	Epifactor	DHPS	PRPF31	0.83705223	3.22E-33
THYM	Epifactor	DHPS	CXXC1	0.841976983	5.96E-34
THYM	Epifactor	DHPS	TAF10	0.842736445	4.57E-34
THYM	Epifactor	DHPS	SS18L2	0.845472994	1.74E-34
THYM	Epifactor	DHPS	HIST1H2AJ	0.847748	7.66E-35
THYM	Epifactor	DHPS	H2AFX	0.859810311	7.89E-37
THYM	Epifactor	DHPS	HIRIP3	0.863441643	1.83E-37
THYM	Epifactor	DHPS	PRMT7	0.865781191	6.97E-38
THYM	Epifactor	DHPS	BRMS1	0.868464313	2.26E-38
THYM	Epifactor	DHPS	HIST2H2AC	0.873560481	2.47E-39
THYM	Epifactor	DHPS	SUV39H1	0.874614201	1.54E-39
THYM	Epifactor	DHPS	PPM1G	0.879049676	2.04E-40
THYM	Epifactor	DHPS	TRIM28	0.888008143	2.65E-42
THYM	Epifactor	DHPS	PPP4C	0.894119595	1.10E-43
THYM	Epifactor	DHPS	TFPT	0.897123645	2.15E-44
THYM	Epifactor	DHPS	RUVBL2	0.901459505	1.85E-45
THYM	IUPHAR	DHPS	CDK9	0.801918479	1.29E-28
THYM	IUPHAR	DHPS	INPP5K	0.802889944	9.90E-29
THYM	IUPHAR	DHPS	CDK5	0.803557104	8.25E-29
THYM	IUPHAR	DHPS	PSMB2	0.806133719	4.06E-29
THYM	IUPHAR	DHPS	PKN1	0.807432172	2.83E-29
THYM	IUPHAR	DHPS	TOP1MT	0.810909795	1.06E-29
THYM	IUPHAR	DHPS	TP53RK	0.811968998	7.81E-30
THYM	IUPHAR	DHPS	VRK3	0.812275868	7.15E-30
THYM	IUPHAR	DHPS	PSMB6	0.816618302	2.02E-30
THYM	IUPHAR	DHPS	NT5M	0.819625684	8.23E-31
THYM	IUPHAR	DHPS	SLC27A5	0.820043862	7.26E-31
THYM	IUPHAR	DHPS	MVD	0.82293193	3.01E-31
THYM	IUPHAR	DHPS	SIRT6	0.826560667	9.76E-32
THYM	IUPHAR	DHPS	CSNK2B	0.833712964	9.78E-33
THYM	IUPHAR	DHPS	BIRC5	0.836011698	4.56E-33
THYM	IUPHAR	DHPS	PHKG2	0.845046095	2.02E-34
THYM	IUPHAR	DHPS	TWF2	0.853785998	8.16E-36
THYM	IUPHAR	DHPS	PPIA	0.865629013	7.43E-38
THYM	IUPHAR	DHPS	PRMT7	0.865781191	6.97E-38
THYM	IUPHAR	DHPS	SUV39H1	0.874614201	1.54E-39
THYM	IUPHAR	DHPS	TRIM28	0.888008143	2.65E-42
THYM	Kinase	DHPS	CDK9	0.801918479	1.29E-28
THYM	Kinase	DHPS	CDK5	0.803557104	8.25E-29
THYM	Kinase	DHPS	PKN1	0.807432172	2.83E-29
THYM	Kinase	DHPS	TP53RK	0.811968998	7.81E-30
THYM	Kinase	DHPS	VRK3	0.812275868	7.15E-30
THYM	Kinase	DHPS	ADCK4	0.818201694	1.26E-30
THYM	Kinase	DHPS	PHKG2	0.845046095	2.02E-34
THYM	Kinase	DHPS	TRIM28	0.888008143	2.65E-42
THYM	TF	DHPS	USF2	0.800852909	1.72E-28
THYM	TF	DHPS	E2F1	0.804180678	6.96E-29
THYM	TF	DHPS	ETV2	0.811648495	8.57E-30
THYM	TF	DHPS	ZGPAT	0.812620309	6.48E-30
THYM	TF	DHPS	IRF3	0.81434506	3.93E-30
THYM	TF	DHPS	TIGD3	0.825485774	1.37E-31
THYM	TF	DHPS	MAZ	0.826098637	1.13E-31
THYM	TF	DHPS	ZNF428	0.826203884	1.09E-31
THYM	TF	DHPS	USF1	0.826413214	1.02E-31
THYM	TF	DHPS	ZNF668	0.827368678	7.57E-32
THYM	TF	DHPS	MYPOP	0.836739476	3.57E-33
THYM	TF	DHPS	CXXC1	0.841976983	5.96E-34
THYM	TF	DHPS	ZNF688	0.845084611	1.99E-34
THYM	TF	DHPS	DRAP1	0.862177095	3.06E-37
THYM	TF	DHPS	ZNF653	0.867087756	4.04E-38
THYM	TF	DHPS	RBCK1	0.872078996	4.74E-39
THYM	TF	DHPS	MXD3	0.875426292	1.07E-39
THYM	TF	DHPS	THYN1	0.896276536	3.43E-44
THYM	TF	DHPS	GTF3A	0.900329719	3.55E-45
THYM	TF	DHPS	ZNF444	0.918600052	3.27E-50
THYM	TF	DHPS	PIN1	0.922528085	1.89E-51
THYM	TSG	DHPS	FBXO25	0.800287608	2.00E-28
THYM	TSG	DHPS	E2F1	0.804180678	6.96E-29
THYM	TSG	DHPS	AIF1	0.808537711	2.07E-29
THYM	TSG	DHPS	TSSC4	0.810706828	1.12E-29
THYM	TSG	DHPS	PLEKHO1	0.810822075	1.09E-29
THYM	TSG	DHPS	ANP32A	0.813801875	4.60E-30
THYM	TSG	DHPS	IRF3	0.81434506	3.93E-30
THYM	TSG	DHPS	SIRT6	0.826560667	9.76E-32
THYM	TSG	DHPS	ZNF668	0.827368678	7.57E-32
THYM	TSG	DHPS	GNB2L1	0.841394752	7.29E-34
THYM	TSG	DHPS	H2AFX	0.859810311	7.89E-37
THYM	TSG	DHPS	NPRL2	0.862136826	3.11E-37
THYM	TSG	DHPS	BAX	0.86296675	2.22E-37
THYM	TSG	DHPS	BRMS1	0.868464313	2.26E-38
THYM	TSG	DHPS	PFN1	0.869709738	1.32E-38
THYM	TSG	DHPS	HTRA2	0.884320599	1.65E-41
THYM	TSG	DHPS	AIP	0.908201347	3.24E-47
THYM	TSG	DHPS	PIN1	0.922528085	1.89E-51
UCS	Cell metabolism gene	DHPS	UROD	0.800228685	2.03E-28
UCS	Cell metabolism gene	DHPS	INPP5K	0.802889944	9.90E-29
UCS	Cell metabolism gene	DHPS	TOMM22	0.804302667	6.73E-29
UCS	Cell metabolism gene	DHPS	PSMB2	0.806133719	4.06E-29
UCS	Cell metabolism gene	DHPS	SNRPE	0.809467532	1.59E-29
UCS	Cell metabolism gene	DHPS	SNRPD3	0.809534889	1.56E-29
UCS	Cell metabolism gene	DHPS	AAAS	0.80992629	1.40E-29
UCS	Cell metabolism gene	DHPS	PSME1	0.811532262	8.86E-30
UCS	Cell metabolism gene	DHPS	PSMD8	0.812222167	7.27E-30
UCS	Cell metabolism gene	DHPS	ANP32A	0.813801875	4.60E-30
UCS	Cell metabolism gene	DHPS	ACTB	0.813859161	4.53E-30
UCS	Cell metabolism gene	DHPS	NOP56	0.814630634	3.62E-30
UCS	Cell metabolism gene	DHPS	SNRPF	0.816397681	2.15E-30
UCS	Cell metabolism gene	DHPS	PSMB6	0.816618302	2.02E-30
UCS	Cell metabolism gene	DHPS	MED18	0.817812788	1.42E-30
UCS	Cell metabolism gene	DHPS	TIMM50	0.818809864	1.05E-30
UCS	Cell metabolism gene	DHPS	POLD1	0.818991642	9.96E-31
UCS	Cell metabolism gene	DHPS	OAZ1	0.819477077	8.61E-31
UCS	Cell metabolism gene	DHPS	NT5M	0.819625684	8.23E-31
UCS	Cell metabolism gene	DHPS	SLC27A5	0.820043862	7.26E-31
UCS	Cell metabolism gene	DHPS	TOMM40	0.822190537	3.78E-31
UCS	Cell metabolism gene	DHPS	MVD	0.82293193	3.01E-31
UCS	Cell metabolism gene	DHPS	POLR2J	0.824446445	1.89E-31
UCS	Cell metabolism gene	DHPS	FPGS	0.829289049	4.11E-32
UCS	Cell metabolism gene	DHPS	GCDH	0.829669805	3.64E-32
UCS	Cell metabolism gene	DHPS	TXN	0.829982366	3.29E-32
UCS	Cell metabolism gene	DHPS	SEC61B	0.830627648	2.67E-32
UCS	Cell metabolism gene	DHPS	SEC61G	0.830985678	2.38E-32
UCS	Cell metabolism gene	DHPS	TIMM8B	0.835210095	5.96E-33
UCS	Cell metabolism gene	DHPS	APRT	0.83687289	3.42E-33
UCS	Cell metabolism gene	DHPS	PHKG2	0.845046095	2.02E-34
UCS	Cell metabolism gene	DHPS	PGP	0.845156968	1.94E-34
UCS	Cell metabolism gene	DHPS	TIMM13	0.84555343	1.69E-34
UCS	Cell metabolism gene	DHPS	ZNRD1	0.84954096	3.98E-35
UCS	Cell metabolism gene	DHPS	POLR3K	0.850427306	2.87E-35
UCS	Cell metabolism gene	DHPS	APOA1	0.850945413	2.37E-35
UCS	Cell metabolism gene	DHPS	DUT	0.851977124	1.61E-35
UCS	Cell metabolism gene	DHPS	PSMA5	0.853884226	7.86E-36
UCS	Cell metabolism gene	DHPS	GUK1	0.854142524	7.13E-36
UCS	Cell metabolism gene	DHPS	TIMM17B	0.854547493	6.11E-36
UCS	Cell metabolism gene	DHPS	PSMA4	0.855623176	4.05E-36
UCS	Cell metabolism gene	DHPS	PSMB10	0.856010669	3.49E-36
UCS	Cell metabolism gene	DHPS	MTMR14	0.856354286	3.05E-36
UCS	Cell metabolism gene	DHPS	SNRPD1	0.860201049	6.75E-37
UCS	Cell metabolism gene	DHPS	DGUOK	0.861430141	4.13E-37
UCS	Cell metabolism gene	DHPS	EBP	0.861537716	3.95E-37
UCS	Cell metabolism gene	DHPS	POLD2	0.861594072	3.87E-37
UCS	Cell metabolism gene	DHPS	POLA2	0.862804743	2.37E-37
UCS	Cell metabolism gene	DHPS	LSM2	0.86764539	3.19E-38
UCS	Cell metabolism gene	DHPS	PSMB7	0.868184227	2.54E-38
UCS	Cell metabolism gene	DHPS	LSM5	0.868839426	1.92E-38
UCS	Cell metabolism gene	DHPS	PSMA6	0.869798214	1.28E-38
UCS	Cell metabolism gene	DHPS	PSMB3	0.87262453	3.73E-39
UCS	Cell metabolism gene	DHPS	LSM3	0.879874318	1.39E-40
UCS	Cell metabolism gene	DHPS	DTYMK	0.882929222	3.25E-41
UCS	Cell metabolism gene	DHPS	ACOT8	0.887133617	4.12E-42
UCS	Cell metabolism gene	DHPS	LSM4	0.892346994	2.83E-43
UCS	Cell metabolism gene	DHPS	SNRPB	0.892806729	2.22E-43
UCS	Cell metabolism gene	DHPS	SNRPD2	0.893285235	1.72E-43
UCS	Cell metabolism gene	DHPS	PAFAH1B3	0.895256947	5.97E-44
UCS	Cell metabolism gene	DHPS	PSMD13	0.900671621	2.92E-45
UCS	Cell metabolism gene	DHPS	PSMC3	0.902376528	1.09E-45
UCS	Cell metabolism gene	DHPS	GALK1	0.916398706	1.52E-49
UCS	CGC	DHPS	RECQL4	0.813066052	5.70E-30
UCS	CGC	DHPS	POLD1	0.818991642	9.96E-31
UCS	CGC	DHPS	BCL2L12	0.822156006	3.82E-31
UCS	CGC	DHPS	RBM10	0.833359769	1.10E-32
UCS	CGC	DHPS	BAX	0.86296675	2.22E-37
UCS	CGC	DHPS	SDHAF2	0.885020708	1.17E-41
UCS	CGC	DHPS	TFPT	0.897123645	2.15E-44
UCS	Epifactor	DHPS	CDK9	0.801918479	1.29E-28
UCS	Epifactor	DHPS	CDK5	0.803557104	8.25E-29
UCS	Epifactor	DHPS	CCDC101	0.803637202	8.07E-29
UCS	Epifactor	DHPS	SUV420H2	0.805991732	4.22E-29
UCS	Epifactor	DHPS	PKN1	0.807432172	2.83E-29
UCS	Epifactor	DHPS	HIST1H3C	0.809244967	1.70E-29
UCS	Epifactor	DHPS	ZGPAT	0.812620309	6.48E-30
UCS	Epifactor	DHPS	ANP32A	0.813801875	4.60E-30
UCS	Epifactor	DHPS	ACTB	0.813859161	4.53E-30
UCS	Epifactor	DHPS	HIST1H3F	0.814931367	3.31E-30
UCS	Epifactor	DHPS	H1FX	0.81826161	1.24E-30
UCS	Epifactor	DHPS	INO80E	0.818899432	1.02E-30
UCS	Epifactor	DHPS	RBX1	0.819538983	8.45E-31
UCS	Epifactor	DHPS	HIST1H2BH	0.820183583	6.96E-31
UCS	Epifactor	DHPS	MAZ	0.826098637	1.13E-31
UCS	Epifactor	DHPS	PAF1	0.826451916	1.01E-31
UCS	Epifactor	DHPS	SIRT6	0.826560667	9.76E-32
UCS	Epifactor	DHPS	ZNHIT1	0.828663104	5.02E-32
UCS	Epifactor	DHPS	MCRS1	0.829476098	3.87E-32
UCS	Epifactor	DHPS	HMGN2	0.829712183	3.59E-32
UCS	Epifactor	DHPS	PRPF31	0.83705223	3.22E-33
UCS	Epifactor	DHPS	CXXC1	0.841976983	5.96E-34
UCS	Epifactor	DHPS	TAF10	0.842736445	4.57E-34
UCS	Epifactor	DHPS	SS18L2	0.845472994	1.74E-34
UCS	Epifactor	DHPS	HIST1H2AJ	0.847748	7.66E-35
UCS	Epifactor	DHPS	H2AFX	0.859810311	7.89E-37
UCS	Epifactor	DHPS	HIRIP3	0.863441643	1.83E-37
UCS	Epifactor	DHPS	PRMT7	0.865781191	6.97E-38
UCS	Epifactor	DHPS	BRMS1	0.868464313	2.26E-38
UCS	Epifactor	DHPS	HIST2H2AC	0.873560481	2.47E-39
UCS	Epifactor	DHPS	SUV39H1	0.874614201	1.54E-39
UCS	Epifactor	DHPS	PPM1G	0.879049676	2.04E-40
UCS	Epifactor	DHPS	TRIM28	0.888008143	2.65E-42
UCS	Epifactor	DHPS	PPP4C	0.894119595	1.10E-43
UCS	Epifactor	DHPS	TFPT	0.897123645	2.15E-44
UCS	Epifactor	DHPS	RUVBL2	0.901459505	1.85E-45
UCS	IUPHAR	DHPS	CDK9	0.801918479	1.29E-28
UCS	IUPHAR	DHPS	INPP5K	0.802889944	9.90E-29
UCS	IUPHAR	DHPS	CDK5	0.803557104	8.25E-29
UCS	IUPHAR	DHPS	PSMB2	0.806133719	4.06E-29
UCS	IUPHAR	DHPS	PKN1	0.807432172	2.83E-29
UCS	IUPHAR	DHPS	TOP1MT	0.810909795	1.06E-29
UCS	IUPHAR	DHPS	TP53RK	0.811968998	7.81E-30
UCS	IUPHAR	DHPS	VRK3	0.812275868	7.15E-30
UCS	IUPHAR	DHPS	PSMB6	0.816618302	2.02E-30
UCS	IUPHAR	DHPS	NT5M	0.819625684	8.23E-31
UCS	IUPHAR	DHPS	SLC27A5	0.820043862	7.26E-31
UCS	IUPHAR	DHPS	MVD	0.82293193	3.01E-31
UCS	IUPHAR	DHPS	SIRT6	0.826560667	9.76E-32
UCS	IUPHAR	DHPS	CSNK2B	0.833712964	9.78E-33
UCS	IUPHAR	DHPS	BIRC5	0.836011698	4.56E-33
UCS	IUPHAR	DHPS	PHKG2	0.845046095	2.02E-34
UCS	IUPHAR	DHPS	TWF2	0.853785998	8.16E-36
UCS	IUPHAR	DHPS	PPIA	0.865629013	7.43E-38
UCS	IUPHAR	DHPS	PRMT7	0.865781191	6.97E-38
UCS	IUPHAR	DHPS	SUV39H1	0.874614201	1.54E-39
UCS	IUPHAR	DHPS	TRIM28	0.888008143	2.65E-42
UCS	Kinase	DHPS	CDK9	0.801918479	1.29E-28
UCS	Kinase	DHPS	CDK5	0.803557104	8.25E-29
UCS	Kinase	DHPS	PKN1	0.807432172	2.83E-29
UCS	Kinase	DHPS	TP53RK	0.811968998	7.81E-30
UCS	Kinase	DHPS	VRK3	0.812275868	7.15E-30
UCS	Kinase	DHPS	ADCK4	0.818201694	1.26E-30
UCS	Kinase	DHPS	PHKG2	0.845046095	2.02E-34
UCS	Kinase	DHPS	TRIM28	0.888008143	2.65E-42
UCS	TF	DHPS	USF2	0.800852909	1.72E-28
UCS	TF	DHPS	E2F1	0.804180678	6.96E-29
UCS	TF	DHPS	ETV2	0.811648495	8.57E-30
UCS	TF	DHPS	ZGPAT	0.812620309	6.48E-30
UCS	TF	DHPS	IRF3	0.81434506	3.93E-30
UCS	TF	DHPS	TIGD3	0.825485774	1.37E-31
UCS	TF	DHPS	MAZ	0.826098637	1.13E-31
UCS	TF	DHPS	ZNF428	0.826203884	1.09E-31
UCS	TF	DHPS	USF1	0.826413214	1.02E-31
UCS	TF	DHPS	ZNF668	0.827368678	7.57E-32
UCS	TF	DHPS	MYPOP	0.836739476	3.57E-33
UCS	TF	DHPS	CXXC1	0.841976983	5.96E-34
UCS	TF	DHPS	ZNF688	0.845084611	1.99E-34
UCS	TF	DHPS	DRAP1	0.862177095	3.06E-37
UCS	TF	DHPS	ZNF653	0.867087756	4.04E-38
UCS	TF	DHPS	RBCK1	0.872078996	4.74E-39
UCS	TF	DHPS	MXD3	0.875426292	1.07E-39
UCS	TF	DHPS	THYN1	0.896276536	3.43E-44
UCS	TF	DHPS	GTF3A	0.900329719	3.55E-45
UCS	TF	DHPS	ZNF444	0.918600052	3.27E-50
UCS	TF	DHPS	PIN1	0.922528085	1.89E-51
UCS	TSG	DHPS	FBXO25	0.800287608	2.00E-28
UCS	TSG	DHPS	E2F1	0.804180678	6.96E-29
UCS	TSG	DHPS	AIF1	0.808537711	2.07E-29
UCS	TSG	DHPS	TSSC4	0.810706828	1.12E-29
UCS	TSG	DHPS	PLEKHO1	0.810822075	1.09E-29
UCS	TSG	DHPS	ANP32A	0.813801875	4.60E-30
UCS	TSG	DHPS	IRF3	0.81434506	3.93E-30
UCS	TSG	DHPS	SIRT6	0.826560667	9.76E-32
UCS	TSG	DHPS	ZNF668	0.827368678	7.57E-32
UCS	TSG	DHPS	GNB2L1	0.841394752	7.29E-34
UCS	TSG	DHPS	H2AFX	0.859810311	7.89E-37
UCS	TSG	DHPS	NPRL2	0.862136826	3.11E-37
UCS	TSG	DHPS	BAX	0.86296675	2.22E-37
UCS	TSG	DHPS	BRMS1	0.868464313	2.26E-38
UCS	TSG	DHPS	PFN1	0.869709738	1.32E-38
UCS	TSG	DHPS	HTRA2	0.884320599	1.65E-41
UCS	TSG	DHPS	AIP	0.908201347	3.24E-47
UCS	TSG	DHPS	PIN1	0.922528085	1.89E-51
UVM	Cell metabolism gene	DHPS	GNB2	0.803274812	3.12E-19
UVM	Cell metabolism gene	DHPS	GPI	0.804222658	2.63E-19
UVM	Cell metabolism gene	DHPS	POLR2I	0.810717541	8.06E-20
UVM	Epifactor	DHPS	PAF1	0.805555371	2.07E-19
UVM	Epifactor	DHPS	RUVBL2	0.816820117	2.54E-20
UVM	Epifactor	DHPS	PRMT1	0.822985645	7.58E-21
UVM	IUPHAR	DHPS	PRMT1	0.822985645	7.58E-21
UVM	TF	DHPS	ZNF444	0.8061208	1.87E-19
UVM	TF	DHPS	THAP7	0.810163284	8.93E-20
UVM	TF	DHPS	ZNF414	0.811619084	6.81E-20
UVM	TSG	DHPS	GADD45GIP1	0.816813641	2.54E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	DHPS	SRM	2.14321209186902	0.000110303983092308
LIHC	DHPS	EIF5A	-2.36221705677847	0.000122033393260438
THCA	DHPS	EIF5A	-1.78363731048148	0.000163107625527599
PRAD	DHPS	EIF5A2	1.76773292297344	0.00192930085721699
STAD	DHPS	EIF5A	-3.31350115276852	0.00239070039242506
KICH	DHPS	EIF5A	1.13226408826506	0.00308787822723389
KICH	DHPS	EIF5A2	2.29158986097535	0.00507164001464844
LUAD	DHPS	EIF5A2	-2.4963976518052	0.00773628245812536
THCA	DHPS	DOHH	-1.77397594528087	0.0113302146920605
ESCA	DHPS	EIF5A	-1.53981930599908	0.013671875
PRAD	DHPS	DOHH	-1.36546815787639	0.0278551491578459
READ	DHPS	DOHH	-2.91730296765426	0.03125
LUSC	DHPS	ODC1	2.44308535501876	0.0322065864649941
CHOL	DHPS	AMD1	-1.47752782809998	0.0390625
ESCA	DHPS	EIF5AL1	-2.32233967926379	0.0419921875
KIRP	DHPS	EIF5AL1	-4.49629470970514	1.17812305688858e-07
LUAD	DHPS	EIF5A	-3.54842210612043	1.73122747932354e-05
THCA	DHPS	EIF5A2	1.86994054726467	1.93116089157046e-10
KIRP	DHPS	SRM	-1.81615580400449	2.56113708019257e-08
BRCA	DHPS	EIF5A	-1.08858196408792	6.35242413482859e-13
LUAD	DHPS	SRM	-2.81631030957382	7.49985882331115e-10
BRCA	DHPS	EIF5AL1	-1.22214040868425	7.69375537587838e-12
THCA	DHPS	EIF5AL1	-1.0790957838624	8.27580425414032e-05
LUAD	DHPS	EIF5AL1	-3.12239466078497	9.17061162320812e-07
LUSC	DHPS	SRM	-4.19028774458098	9.39810820844289e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DHPS

NIF3L1, NUDT18, EIF5A2, RPL9, ARF6, SRRM2, MAPK3, ACTR2, ANKMY2, ANP32B, ARIH1, ARPC1B, CTPS2, AAMP, RPA3, SAE1, DPP8, HNRNPF, HSF1, PLIN3, PPP2R5D, SRP9, SURF2, DHPS, EIF5A, PTPRH, RAB27B, REL, ZNF138, VASH1, WDYHV1, BRCA1, TIRAP, SUSD4, BYSL, SPHK1, KCNAB3, CDK17, PTPN7, PTPRR, DUSP19, DUSP28, FAM19A3, SAFB2, ARHGAP15, CFAP46, ZNF414, SFPQ, SPATA24, PROSER2, LRRC6, PTPDC1, EXOSC4, EXOSC2, EXOSC7, RNH70, TGFB1, RECQL4, PAX6, LNX1, MEOX2, RBP1, MAPK1, nsp12, nsp16, nsp7, SP110, DRG2, TULP3, ACTR3, ANAPC2, VPS33A, ZNF276, LGR5, MYEOV2, DLX1, EPS8L1, KIAA1522, PLCD3, CCHCR1, SRSF2, C9orf170, SPANXN4, TRAV20, PADI6, PRTN3, FAM133A, KCNN4, ZRANB1, M, N, nsp13, nsp14, nsp8, nsp9, FBXO32,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DHPS	chr19	12786830	C	T	single_nucleotide_variant	Uncertain_significance	Neurodevelopmental_disorder_with_seizures_and_speech_and_walking_impairment\|not_provided	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant
DHPS	chr19	12786927	GATGTAA	G	Deletion	Conflicting_interpretations_of_pathogenicity	Neurodevelopmental_disorder_with_seizures_and_speech_and_walking_impairment\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001822\|inframe_deletion,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001822\|inframe_deletion,SO:0001627\|intron_variant
DHPS	chr19	12790510	T	C	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Neurodevelopmental_disorder_with_seizures_and_speech_and_walking_impairment\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
DHPS	chr19	12792580	T	C	single_nucleotide_variant	Uncertain_significance	Neurodevelopmental_disorder_with_seizures_and_speech_and_walking_impairment\|not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DHPS	BLCA	chr19	12792434	12792434	G	T	Missense_Mutation	p.F49L	10
DHPS	BLCA	chr19	12792434	12792434	G	T	Missense_Mutation		10
DHPS	BRCA	chr19	12788192	12788192	T	G	Missense_Mutation	p.S233R	3
DHPS	BRCA	chr19	12792473	12792473	G	C	Missense_Mutation	p.F36L	3
DHPS	STAD	chr19	12791075	12791075	C	T	Missense_Mutation	p.R91H	3
DHPS	UVM	chr19	12790677	12790677	C	T	Silent		2
DHPS	CESC	chr19	12791062	12791062	G	C	Silent		2
DHPS	STAD	chr19	12790343	12790343	C	T	Silent	p.T202T	2
DHPS	UVM	chr19	12790677	12790677	C	T	Silent	p.A144A	2
DHPS	PRAD	chr19	12790632	12790632	C	A	Silent	p.R159R	2
DHPS	UCEC	chr19	12786878	12786878	C	T	Missense_Mutation	p.E323K	2
DHPS	BLCA	chr19	12790678	12790678	G	A	Missense_Mutation	p.A144V	2
DHPS	SKCM	chr19	12790694	12790694	G	A	Missense_Mutation	p.L139F	2
DHPS	UCEC	chr19	12787986	12787986	C	T	Missense_Mutation	p.C275Y	2
DHPS	BLCA	chr19	12790506	12790506	C	T	Silent		2
DHPS	BLCA	chr19	12792434	12792434	G	A	Silent	p.F49F	2
DHPS	SKCM	chr19	12791116	12791116	C	T	Silent	p.L77L	2
DHPS	UCEC	chr19	12788163	12788163	G	A	Silent	p.G242	2
DHPS	BRCA	chr19	12788175	12788175	G	A	Silent	p.D238	2
DHPS	SKCM	chr19	12790530	12790530	G	A	Silent	p.I166I	2
DHPS	UCEC	chr19	12790661	12790661	C	T	Missense_Mutation	p.E150K	2
DHPS	HNSC	chr19	12790281	12790281	C	T	Nonsense_Mutation	p.W223*	2
DHPS	UCEC	chr19	12791009	12791009	C	T	Splice_Site	e2+1	2
DHPS	LUAD	chr19	12786738	12786738	C	T	Missense_Mutation	p.D342N	2
DHPS	UCEC	chr19	12791010	12791010	G	A	Missense_Mutation	p.R113C	2
DHPS	BLCA	chr19	12787963	12787963	C	A	Missense_Mutation		2
DHPS	CESC	chr19	12788010	12788010	T	C	Missense_Mutation		2
DHPS	UCEC	chr19	12791091	12791091	C	T	Missense_Mutation	p.D86N	2
DHPS	CESC	chr19	12791059	12791059	G	T	Missense_Mutation		2
DHPS	STAD	chr19	12790510	12790510	T	A	Missense_Mutation	p.N173I	2
DHPS	UCEC	chr19	12792409	12792409	T	A	Missense_Mutation	p.N58Y	2
DHPS	PAAD	chr19	12790297	12790297	C	A	Nonsense_Mutation	p.E218*	2
DHPS	CESC	chr19	12791023	12791023	G	T	Silent		2
DHPS	STAD	chr19	12792443	12792443	C	T	Silent	p.L46L	2
DHPS	LIHC	chr19	12790986	12790986	G	T	Missense_Mutation		1
DHPS	BLCA	chr19	12786939	12786939	G	A	Silent	p.Y302Y	1
DHPS	PAAD	chr19	12790297	12790297	C	A	Nonsense_Mutation		1
DHPS	LIHC	chr19	12792433	12792433	C	A	Missense_Mutation		1
DHPS	BLCA	chr19	12792570	12792570	G	A	Missense_Mutation	p.S4F	1
DHPS	PRAD	chr19	12786735	12786735	C	T	Missense_Mutation	p.A343T	1
DHPS	CESC	chr19	12788010	12788010	T	C	Missense_Mutation	p.N267S	1
DHPS	THYM	chr19	12792393	12792393	A	T	Missense_Mutation		1
DHPS	LIHC	chr19	12791048	12791048	A	-	Frame_Shift_Del	p.F100fs	1
DHPS	COAD	chr19	12786914	12786914	C	A	Nonsense_Mutation	p.E311X	1
DHPS	LIHC	chr19	12791122	12791122	T	-	Frame_Shift_Del	p.E75fs	1
DHPS	COAD	chr19	12786945	12786945	G	A	Silent	p.A300A	1
DHPS	LUAD	chr19	12788168	12788168	G	A	Silent	p.L241L	1
DHPS	COAD	chr19	12790663	12790663	C	T	Missense_Mutation	p.G149D	1
DHPS	BLCA	chr19	12792437	12792437	G	A	Silent		1
DHPS	LUAD	chr19	12790352	12790352	T	C	Silent	p.V199V	1
DHPS	COAD	chr19	12790981	12790981	G	T	Missense_Mutation	p.H122Q	1
DHPS	BLCA	chr19	12792570	12792570	G	A	Missense_Mutation		1
DHPS	LUAD	chr19	12790715	12790715	C	A	Missense_Mutation	p.A132S	1
DHPS	SKCM	chr19	12792466	12792466	C	G	Missense_Mutation	p.G39R	1
DHPS	STAD	chr19	12791075	12791075	C	T	Missense_Mutation		1
DHPS	KIRC	chr19	12790293	12790302	GACTCTGGGT	-	Frame_Shift_Del	p.216_219del	1
DHPS	LUSC	chr19	12790661	12790661	C	A	Nonsense_Mutation	p.E150*	1
DHPS	KIRC	chr19	12790293	12790302	GACTCTGGGT	-	Frame_Shift_Del	p.NPES216fs	1
DHPS	BLCA	chr19	12790678	12790678	G	A	Missense_Mutation		1
DHPS	PAAD	chr19	12790297	12790297	C	A	Nonsense_Mutation	p.E218X	1
DHPS	KIRP	chr19	12788201	12788201	G	T	Missense_Mutation		1
DHPS	BLCA	chr19	12792437	12792437	G	A	Silent	p.A48A	1

Copy number variation (CNV) of DHPS
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DHPS
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99124	UCEC	TCGA-PG-A7D5-01A	ASNA1	chr19	12849472	+	DHPS	chr19	12791139	-
102383	OV	TCGA-09-1667-01C	DHPS	chr19	12792374	-	CACNA1A	chr19	13325422	-
99124	N/A	BQ436553	DHPS	chr19	12786856	+	DHPS	chr19	12791093	-
99124	N/A	CV364179	DHPS	chr19	12791114	+	DHPS	chr19	12792684	-
102959	BRCA	TCGA-AN-A0XT-01A	DHPS	chr19	12792332	-	HOOK2	chr19	12878238	-
102520	N/A	BI494899	DHPS	chr19	12786529	-	MGAT3	chr22	39847859	+
102974	N/A	AA643868	DHPS	chr19	12783661	-	WDR83OS	chr19	12781635	-
99124	N/A	CB050790	IMMP2L	chr7	111125651	-	DHPS	chr19	12786533	+
99124	BLCA	TCGA-CF-A47V-01A	WDR83	chr19	12786594	-	DHPS	chr19	12786873	-
99124	BLCA	TCGA-S5-AA26-01A	WDR83	chr19	12786619	-	DHPS	chr19	12786856	-
99124	BRCA	TCGA-BH-A28O-01A	WDR83	chr19	12786620	-	DHPS	chr19	12787983	-
99124	BRCA	TCGA-LD-A7W6-01A	WDR83	chr19	12786619	-	DHPS	chr19	12786871	-
99124	CESC	TCGA-DG-A2KH-01A	WDR83	chr19	12786635	-	DHPS	chr19	12786913	-
99124	CESC	TCGA-EK-A3GM-01A	WDR83	chr19	12786621	-	DHPS	chr19	12786881	-
99124	CESC	TCGA-EK-A3GN-01A	WDR83	chr19	12786620	-	DHPS	chr19	12786854	-
99124	CESC	TCGA-EX-A1H5-01A	WDR83	chr19	12786568	-	DHPS	chr19	12786852	-
99124	CESC	TCGA-FU-A23K-01A	WDR83	chr19	12786621	-	DHPS	chr19	12786852	-
99124	CESC	TCGA-MY-A913-01A	WDR83	chr19	12786617	-	DHPS	chr19	12786871	-
99124	KIRC	TCGA-BP-4992-01A	WDR83	chr19	12786619	-	DHPS	chr19	12786874	-
99124	LGG	TCGA-DB-A75O-01A	WDR83	chr19	12786617	-	DHPS	chr19	12788153	-
99124	LUSC	TCGA-56-A4BX-01A	WDR83	chr19	12786390	-	DHPS	chr19	12786688	-
99124	LUSC	TCGA-56-A4BX-01A	WDR83	chr19	12786617	-	DHPS	chr19	12786854	-
99124	OV	TCGA-29-A5NZ-01A	WDR83	chr19	12786455	+	DHPS	chr19	12786734	-
99124	OV	TCGA-31-1951-01A	WDR83	chr19	12786631	-	DHPS	chr19	12788070	-
99124	PRAD	TCGA-HC-8261-01A	WDR83	chr19	12786642	+	DHPS	chr19	12786854	-
99124	PRAD	TCGA-HC-8265-01A	WDR83	chr19	12786564	-	DHPS	chr19	12786851	-
99124	SARC	TCGA-DX-A3UF-01A	WDR83	chr19	12786620	-	DHPS	chr19	12786852	-
99124	SARC	TCGA-IW-A3M5-01A	WDR83	chr19	12786623	-	DHPS	chr19	12787950	-
99124	STAD	TCGA-2H-A9GJ-01A7	WDR83	chr19	12786619	-	DHPS	chr19	12788150	-
99124	STAD	TCGA-L5-A4OR-01A4	WDR83	chr19	12786594	+	DHPS	chr19	12792478	-
99124	STAD	TCGA-R6-A8WC-01A6	WDR83	chr19	12786614	-	DHPS	chr19	12787966	-
99124	UCEC	TCGA-A5-A1OH-01A	WDR83	chr19	12786620	-	DHPS	chr19	12786876	-
99124	UCEC	TCGA-EY-A2OQ-01A	WDR83	chr19	12786597	-	DHPS	chr19	12786855	-
99124	N/A	BF591524	WDR83	chr19	12786747	+	DHPS	chr19	12786831	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	DHPS	0.0157702036319335	0.44
KIRC	DHPS	0.0241175991451159	0.65
BRCA	DHPS	0.0266597109447851	0.69

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	DHPS	0.040282776770412	1
LUSC	DHPS	0.013992574018335	0.43
LGG	DHPS	0.00153351004741018	0.051
BRCA	DHPS	0.0192873346354188	0.58
THYM	DHPS	0.0049978946722573	0.16

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P49366	DB03639	1-Guanidinium-7-Aminoheptane	Inhibitor	Small molecule	Experimental
P49366	DB03639	1-Guanidinium-7-Aminoheptane	Inhibitor

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0557874	Global developmental delay	1	GENOMICS_ENGLAND