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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: FOXO3 (NCBI Gene ID:2309)

Gene Summary

Gene Summary

Gene Information	Gene Name: FOXO3
	Gene ID: 2309
	Gene Symbol	FOXO3
	Gene ID	2309
	Gene Name	forkhead box O3
	Synonyms	AF6q21\|FKHRL1\|FKHRL1P2\|FOXO2\|FOXO3A
	Cytomap	6q21
	Type of Gene	protein-coding
	Description	forkhead box protein O3forkhead box O3Aforkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
	Modification date	20200329
	UniProtAcc	O43524

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FOXO3	GO:0000122	negative regulation of transcription by RNA polymerase II	20371612
Hgene	FOXO3	GO:0006417	regulation of translation	21329882
Hgene	FOXO3	GO:0043065	positive regulation of apoptotic process	20371612
Hgene	FOXO3	GO:0045648	positive regulation of erythrocyte differentiation	14734530
Hgene	FOXO3	GO:0045893	positive regulation of transcription, DNA-templated	10102273\|15084260
Hgene	FOXO3	GO:0045944	positive regulation of transcription by RNA polymerase II	10102273\|14734530

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
FOXO3	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'FOXO3[title] AND translation [title] AND human.'

Gene	Title	PMID
FOXO3	RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation	30591559

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000343882	108984657	108986092	3UTR-3CDS
ENST00000406360	108984657	108986092	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	FOXO3	1.53551104941424	0.00126327311470459
KICH	FOXO3	2.3552334994037	0.00308787822723389
LUSC	FOXO3	-1.27881478220054	0.0174932185880974
STAD	FOXO3	-1.49443762596336	0.0375871751457453

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
GBM	FOXO3	hsa-miR-223-3p	90	-1	0.0166666666666667
KICH	FOXO3	hsa-miR-30c-5p	72	0.417030288653588	0.000131674063476988

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
GBM	FOXO3	2	3	0.00970851687601488	0.570542962962963	0.629531811748054	-0.04387313564856	0.141079836750584
SKCM	FOXO3	2	3	0.0218027475571087	0.572639880952381	0.651418346774194	-0.0615778975532762	0.11831795498129

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	FOXO3	0.027790677	0.017124857
SKCM	FOXO3	0.037016873	0.045830577

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with FOXO3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	FOXO3	GALNT3	0.822835415	3.10E-31
THYM	Cell metabolism gene	FOXO3	PGM3	0.827207814	7.96E-32
THYM	Cell metabolism gene	FOXO3	PIK3C2A	0.836336474	4.09E-33
THYM	CGC	FOXO3	BMPR1A	0.804063076	7.18E-29
THYM	CGC	FOXO3	SETBP1	0.83705612	3.21E-33
THYM	Epifactor	FOXO3	ZZZ3	0.816932803	1.84E-30
THYM	Epifactor	FOXO3	ZMYND11	0.825029945	1.58E-31
THYM	IUPHAR	FOXO3	BMPR1A	0.804063076	7.18E-29
THYM	IUPHAR	FOXO3	RYK	0.812864837	6.04E-30
THYM	IUPHAR	FOXO3	MAP4K3	0.824734638	1.73E-31
THYM	IUPHAR	FOXO3	ZMYND11	0.825029945	1.58E-31
THYM	IUPHAR	FOXO3	PIK3C2A	0.836336474	4.09E-33
THYM	Kinase	FOXO3	BMPR1A	0.804063076	7.18E-29
THYM	Kinase	FOXO3	RYK	0.812864837	6.04E-30
THYM	Kinase	FOXO3	MAP4K3	0.824734638	1.73E-31
THYM	TF	FOXO3	ZNF391	0.805961296	4.26E-29
THYM	TF	FOXO3	ATF7	0.809847416	1.43E-29
THYM	TF	FOXO3	ZZZ3	0.816932803	1.84E-30
THYM	TF	FOXO3	ZNF615	0.82333191	2.66E-31
THYM	TF	FOXO3	SETBP1	0.83705612	3.21E-33
THYM	TSG	FOXO3	BMPR1A	0.804063076	7.18E-29
THYM	TSG	FOXO3	RASSF8	0.813102627	5.64E-30
THYM	TSG	FOXO3	SASH1	0.820416771	6.48E-31
THYM	TSG	FOXO3	ZMYND11	0.825029945	1.58E-31
UCS	Cell metabolism gene	FOXO3	GALNT3	0.822835415	3.10E-31
UCS	Cell metabolism gene	FOXO3	PGM3	0.827207814	7.96E-32
UCS	Cell metabolism gene	FOXO3	PIK3C2A	0.836336474	4.09E-33
UCS	CGC	FOXO3	BMPR1A	0.804063076	7.18E-29
UCS	CGC	FOXO3	SETBP1	0.83705612	3.21E-33
UCS	Epifactor	FOXO3	ZZZ3	0.816932803	1.84E-30
UCS	Epifactor	FOXO3	ZMYND11	0.825029945	1.58E-31
UCS	IUPHAR	FOXO3	BMPR1A	0.804063076	7.18E-29
UCS	IUPHAR	FOXO3	RYK	0.812864837	6.04E-30
UCS	IUPHAR	FOXO3	MAP4K3	0.824734638	1.73E-31
UCS	IUPHAR	FOXO3	ZMYND11	0.825029945	1.58E-31
UCS	IUPHAR	FOXO3	PIK3C2A	0.836336474	4.09E-33
UCS	Kinase	FOXO3	BMPR1A	0.804063076	7.18E-29
UCS	Kinase	FOXO3	RYK	0.812864837	6.04E-30
UCS	Kinase	FOXO3	MAP4K3	0.824734638	1.73E-31
UCS	TF	FOXO3	ZNF391	0.805961296	4.26E-29
UCS	TF	FOXO3	ATF7	0.809847416	1.43E-29
UCS	TF	FOXO3	ZZZ3	0.816932803	1.84E-30
UCS	TF	FOXO3	ZNF615	0.82333191	2.66E-31
UCS	TF	FOXO3	SETBP1	0.83705612	3.21E-33
UCS	TSG	FOXO3	BMPR1A	0.804063076	7.18E-29
UCS	TSG	FOXO3	RASSF8	0.813102627	5.64E-30
UCS	TSG	FOXO3	SASH1	0.820416771	6.48E-31
UCS	TSG	FOXO3	ZMYND11	0.825029945	1.58E-31
UVM	TSG	FOXO3	SASH1	0.811423813	7.07E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	FOXO3	CTNNB1	1.35387002426383	0.000139892101287842
KIRP	FOXO3	CTNNB1	1.44413647030576	0.00019507110118866
HNSC	FOXO3	SIRT1	1.28806606213356	0.000316425336905013
KICH	FOXO3	MYC	1.19194684236579	0.000329077243804932
THCA	FOXO3	EP300	-1.56308189039603	0.00135477973345976
THCA	FOXO3	SIRT3	1.21145960969221	0.00158404977290443
LUSC	FOXO3	MYC	1.80145319254842	0.00250329335752618
LIHC	FOXO3	MDM2	-1.57082310333019	0.00323738381247511
PRAD	FOXO3	EP300	1.28001120737624	0.00383473418852013
LUSC	FOXO3	CTNNB1	-1.53686315879634	0.00765883184752251
STAD	FOXO3	MDM2	-1.99312650485559	0.0132303284481168
UCEC	FOXO3	TP53	2.03295038376694	0.015625
CHOL	FOXO3	SIRT3	-1.28941965967747	0.02734375
LUAD	FOXO3	AKT1	-4.53714460696341	0.0301695351050489
KIRP	FOXO3	CDK2	-1.46324678446435	2.0815059542656e-07
KIRC	FOXO3	MYC	-7.57321539520974	3.45880777969452e-10
THCA	FOXO3	SIRT1	-2.04349883947841	4.53128074436648e-06
KIRC	FOXO3	TP53	-1.43050981150632	4.58942580328929e-09
THCA	FOXO3	TP53	-1.81960143635647	6.18215597921662e-07
STAD	FOXO3	CDK2	-3.08048051920995	6.79492950439454e-06
COAD	FOXO3	YWHAZ	1.56476938178251	7.02440738677979e-05
KIRP	FOXO3	MYC	-5.46971831522856	9.0546440333128e-05
LUAD	FOXO3	CDK2	-3.59648992524193	9.5344646926303e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with FOXO3

SMAD3, SMAD4, YWHAZ, USP7, ATG101, YWHAE, YWHAH, YWHAB, PGK1, FKBP4, GBAS, CTNNB1, SIRT3, MYC, H2AFX, BRCA1, RAD17, ATM, SIRT1, CREBBP, FANCD2, STK4, SMAD1, EP300, VDR, NLK, NR1H2, NR1H3, MDM2, MAPK6, SKP2, ELAVL1, BTRC, MAPK1, CDT1, PCNA, IKBKB, CHUK, AKT1, CDK6, ERBB2IP, YWHAQ, Ep300, CEP44, XPO1, TP53, PPP2CB, PLK1, PPP2R4, PPP2R1A, PPP2R1B, FOXO3B, TRRAP, FOXO6, RBL1, CDC27, FOXK1, RB1, PNKP, ARHGEF2, TAF5L, TERT, Akt1, EGFR, CBY1, HNRNPL, EGLN3, ESR2, ARRB1, KIAA1429, SIRT6, BBC3, BICD2, LDLR, HNRNPH1, S100B, YWHAG,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
FOXO3	chr6	108882830	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FOXO3	chr6	108882843	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FOXO3	chr6	108882915	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FOXO3	chr6	108882994	A	T	single_nucleotide_variant	other	Choroid_plexus_carcinoma	SO:0001587\|nonsense	SO:0001587\|nonsense
FOXO3	chr6	108908518	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FOXO3	chr6	108984735	G	A	single_nucleotide_variant	other	Medulloblastoma	SO:0001587\|nonsense	SO:0001587\|nonsense
FOXO3	chr6	108984783	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FOXO3	chr6	108985057	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FOXO3	chr6	108985221	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FOXO3	chr6	108985530	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FOXO3	chr6	109000742	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FOXO3	chr6	109003321	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
FOXO3	BLCA	chr6	108985092	108985092	C	G	Silent		20
FOXO3	CESC	chr6	108984910	108984910	C	T	Missense_Mutation	p.P292S	6
FOXO3	UVM	chr6	108985561	108985561	G	A	Missense_Mutation	p.V509M	3
FOXO3	HNSC	chr6	108984767	108984767	G	C	Missense_Mutation	p.G244A	3
FOXO3	PAAD	chr6	108985303	108985303	C	A	Missense_Mutation	p.L423M	3
FOXO3	PAAD	chr6	108984662	108984662	C	T	Missense_Mutation	p.S209F	3
FOXO3	PAAD	chr6	108984928	108984928	C	T	Missense_Mutation	p.R298C	3
FOXO3	ESCA	chr6	108882886	108882886	A	C	Missense_Mutation	p.N159H	3
FOXO3	PAAD	chr6	108985053	108985053	T	C	Silent	p.D339D	3
FOXO3	ESCA	chr6	108985092	108985092	C	G	Silent	p.A352	3
FOXO3	STAD	chr6	108985242	108985242	G	A	Silent	p.S402S	2
FOXO3	LIHC	chr6	108986045	108986045	G	-	Frame_Shift_Del	p.W670fs	2
FOXO3	CESC	chr6	108985139	108985139	G	A	Missense_Mutation		2
FOXO3	STAD	chr6	108985055	108985055	A	G	Missense_Mutation	p.D340G	2
FOXO3	BLCA	chr6	108984897	108984897	G	A	Silent	p.Q287Q	2
FOXO3	PAAD	chr6	108984662	108984662	C	T	Missense_Mutation		2
FOXO3	STAD	chr6	108985299	108985299	G	A	Silent	p.S421S	2
FOXO3	LUAD	chr6	108985039	108985039	G	A	Missense_Mutation	p.E335K	2
FOXO3	PAAD	chr6	108984928	108984928	C	T	Missense_Mutation		2
FOXO3	PAAD	chr6	108985303	108985303	C	A	Missense_Mutation		2
FOXO3	SKCM	chr6	108985310	108985310	C	T	Missense_Mutation	p.S425F	2
FOXO3	STAD	chr6	108882982	108882982	G	A	Missense_Mutation		2
FOXO3	STAD	chr6	108882982	108882982	G	A	Missense_Mutation	p.V191M	2
FOXO3	SKCM	chr6	108985241	108985241	C	T	Missense_Mutation	p.S402L	2
FOXO3	KIRP	chr6	108883003	108883003	G	T	Missense_Mutation		2
FOXO3	LUAD	chr6	108984932	108984932	G	T	Missense_Mutation	p.S299I	2
FOXO3	UCEC	chr6	108984839	108984839	C	T	Missense_Mutation	p.A268V	2
FOXO3	ESCA	chr6	108984758	108984758	G	C	Missense_Mutation	p.G241A	2
FOXO3	STAD	chr6	108985139	108985139	G	A	Missense_Mutation	p.R368Q	2
FOXO3	UCEC	chr6	108985322	108985322	C	A	Missense_Mutation	p.S429Y	2
FOXO3	LIHC	chr6	108984701	108984701	G	-	Frame_Shift_Del	p.R222fs	2
FOXO3	BLCA	chr6	108985341	108985341	C	T	Silent	p.F435F	2
FOXO3	UCEC	chr6	108985779	108985779	A	G	Silent	p.Q581	2
FOXO3	BRCA	chr6	108984960	108984964	CTTCC	-	Frame_Shift_Del	p.D308fs	2
FOXO3	ESCA	chr6	108882886	108882886	A	C	Missense_Mutation		1
FOXO3	READ	chr6	108883024	108883024	G	A	Missense_Mutation	p.G205S	1
FOXO3	BLCA	chr6	108882525	108882525	G	A	Silent	p.P38P	1
FOXO3	SKCM	chr6	108984759	108984759	G	A	Silent	p.G241G	1
FOXO3	OV	chr6	108989306	108989306	G	T	Missense_Mutation	p.D68Y	1
FOXO3	GBM	chr6	108985059	108985059	G	A	Silent		1
FOXO3	READ	chr6	108985058	108985058	C	T	Missense_Mutation	p.A341V	1
FOXO3	SARC	chr6	108882511	108882511	C	-	Frame_Shift_Del	p.P34fs	1
FOXO3	UVM	chr6	108882570	108882570	C	T	Silent	p.A53A	1
FOXO3	LIHC	chr6	108882978	108882978	T	C	Silent		1
FOXO3	SKCM	chr6	108984964	108984964	C	T	Missense_Mutation	p.R310C	1
FOXO3	HNSC	chr6	108985068	108985068	G	A	Silent		1
FOXO3	SARC	chr6	108984699	108984699	G	T	Missense_Mutation		1
FOXO3	BLCA	chr6	108985226	108985226	C	G	Missense_Mutation	p.P397R	1
FOXO3	CHOL	chr6	108985269	108985269	C	T	Silent	p.S411S	1
FOXO3	SKCM	chr6	108985383	108985383	G	T	Missense_Mutation	p.Q449H	1
FOXO3	HNSC	chr6	108985068	108985068	G	A	Silent	p.S344S	1
FOXO3	STAD	chr6	108882671	108882671	C	T	Missense_Mutation	p.T87M	1
FOXO3	SARC	chr6	108882648	108882650	CGG	-	In_Frame_Del	p.G83in_frame_del	1
FOXO3	BLCA	chr6	108985224	108985224	C	T	Silent	p.L396L	1
FOXO3	LUAD	chr6	108882901	108882901	G	A	Missense_Mutation	p.D164N	1
FOXO3	COAD	chr6	108984826	108984826	C	A	Missense_Mutation	p.R264S	1
FOXO3	SKCM	chr6	108984980	108984980	C	T	Missense_Mutation	p.S315F	1
FOXO3	BLCA	chr6	108984897	108984897	G	A	Silent		1
FOXO3	STAD	chr6	108985249	108985249	G	-	Frame_Shift_Del	p.G405fs	1
FOXO3	BLCA	chr6	108985225	108985225	C	T	Missense_Mutation	p.P397S	1
FOXO3	LUAD	chr6	108985148	108985148	A	T	Missense_Mutation	p.D371V	1
FOXO3	COAD	chr6	108984984	108984984	C	T	Silent	p.N316N	1
FOXO3	KIRC	chr6	108985226	108985226	C	T	Missense_Mutation	p.P397L	1
FOXO3	THYM	chr6	108882871	108882871	C	T	Missense_Mutation		1
FOXO3	SKCM	chr6	108984893	108984893	C	T	Missense_Mutation	p.S286F	1
FOXO3	BLCA	chr6	108985271	108985271	C	G	Missense_Mutation	p.S412C	1
FOXO3	LUAD	chr6	108985209	108985209	G	A	Silent	p.L391L	1
FOXO3	COAD	chr6	108985061	108985062	CT	-	Frame_Shift_Del	p.342_342del	1
FOXO3	THYM	chr6	108882871	108882871	C	T	Missense_Mutation	p.R154W	1
FOXO3	BLCA	chr6	108985224	108985224	C	T	Silent		1
FOXO3	KIRP	chr6	108985136	108985136	C	T	Missense_Mutation	p.P367L	1
FOXO3	BLCA	chr6	108985623	108985623	C	T	Silent	p.V529V	1
FOXO3	LUAD	chr6	108984958	108984958	G	T	Missense_Mutation	p.D308Y	1
FOXO3	DLBC	chr6	108882915	108882915	C	T	Silent	p.R168R	1
FOXO3	STAD	chr6	108984700	108984700	C	T	Missense_Mutation	p.R222W	1
FOXO3	UCEC	chr6	108985561	108985561	G	T	Missense_Mutation	p.V509L	1
FOXO3	BLCA	chr6	108985225	108985225	C	T	Missense_Mutation		1
FOXO3	SKCM	chr6	108984918	108984918	C	T	Silent	p.S294S	1
FOXO3	BLCA	chr6	108984779	108984779	G	A	Missense_Mutation	p.R248Q	1
FOXO3	STAD	chr6	108985249	108985249	G	-	Frame_Shift_Del	p.T404fs	1
FOXO3	BLCA	chr6	108985271	108985271	C	G	Missense_Mutation		1
FOXO3	LIHC	chr6	108985309	108985310	-	C	Frame_Shift_Ins	p.P425fs	1
FOXO3	SKCM	chr6	108984834	108984834	C	T	Silent	p.R266R	1
FOXO3	BLCA	chr6	108985342	108985342	G	A	Missense_Mutation	p.G436R	1
FOXO3	LUAD	chr6	108882648	108882650	CGG	-	In_Frame_Del	p.IG79del	1
FOXO3	PAAD	chr6	108985160	108985160	C	G	Missense_Mutation	p.T375S	1
FOXO3	BLCA	chr6	108985623	108985623	C	T	Silent		1
FOXO3	SKCM	chr6	108985336	108985336	G	A	Missense_Mutation	p.V434M	1
FOXO3	LUSC	chr6	108985287	108985287	C	A	Silent	p.T417T	1
FOXO3	PRAD	chr6	108984784	108984784	C	T	Missense_Mutation	p.R250W	1
FOXO3	STAD	chr6	108985856	108985857	-	C	Frame_Shift_Ins	p.F607fs	1
FOXO3	BLCA	chr6	108985342	108985342	G	A	Missense_Mutation		1
FOXO3	LIHC	chr6	108882953	108882953	C	-	Frame_Shift_Del	p.S181fs	1
FOXO3	SKCM	chr6	108985335	108985335	G	A	Silent	p.T433T	1
FOXO3	LUSC	chr6	108985121	108985121	G	T	Missense_Mutation	p.C362F	1

Copy number variation (CNV) of FOXO3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across FOXO3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101518	GBM	TCGA-32-1970-01A	FOXO3	chr6	108883032	+	ARMC2	chr6	109274236	+
101518	UVM	TCGA-VD-A8KJ	FOXO3	chr6	108883032	+	ARMC2	chr6	109215669	+
101518	UVM	TCGA-VD-A8KJ	FOXO3	chr6	108883032	+	ARMC2	chr6	109215670	+
101518	UVM	TCGA-VD-A8KJ	FOXO3	chr6	108883032	+	ARMC2	chr6	109220897	+
101518	UVM	TCGA-VD-A8KJ-01A	FOXO3	chr6	108883029	+	ARMC2	chr6	109215667	+
93171	BRCA	TCGA-AR-A1AU-01A	FOXO3	chr6	108883032	+	CHD7	chr8	61653818	+
94452	N/A	AK123151	FOXO3	chr6	108941819	+	FOXN3	chr14	89622792	-
98276	COAD	TCGA-DM-A0XF-01A	FOXO3	chr6	108883032	+	GMDS	chr6	1961200	-
82238	ACC	TCGA-OR-A5LO-01A	FOXO3	chr6	108883032	+	LACE1	chr6	108840900	+
70719	GBM	TCGA-06-2561-01A	FOXO3	chr6	108883032	+	LETMD1	chr12	51442817	+
73590	Non-Cancer	265N	FOXO3	chr6	108986092	+	LINC00222	chr6	109080620	+
98813	BRCA	TCGA-AR-A0TS	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876784	+
98813	BRCA	TCGA-AR-A0TS-01A	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
95340	N/A	W95823	FOXO3	chr6	109003572	+	TCF4	chr18	52891829	-
94647	N/A	AA460379	GSN	chr9	124094859	-	FOXO3	chr6	108908770	-
94647	OV	TCGA-25-1319	HIVEP3	chr1	42094419	-	FOXO3	chr6	108984657	+
94647	.	.	KMT2A	chr11	118353210		FOXO3	chr6	108984657	+
94647	.	.	KMT2A	chr11	118355029		FOXO3	chr6	108984657	+
94647	.	.	KMT2A	chr11	118355029	+	FOXO3	chr	108984657
94647	.	.	KMT2A	chr11	118355690		FOXO3	chr6	108984657	+
94647	N/A	BF989506	NEMF	chr14	50295816	-	FOXO3	chr6	108951529	+
94647	N/A	BE149668	PPM1G	chr2	27604640	+	FOXO3	chr6	108915984	+
94647	BRCA	TCGA-AR-A0TS-01A	PPP1R9A	chr7	94855428	+	FOXO3	chr6	108984658	+
94647	ESCA	TCGA-M9-A5M8	REPS1	chr6	139308666	-	FOXO3	chr6	108882288	+
94647	Non-Cancer	61N	SESN1	chr6	109414997	-	FOXO3	chr6	108984657	+
94653	OV	TCGA-13-1492	TSNARE1	chr8	143484464	-	FOXO3	chr6	108984657	+
94647	N/A	BF432658	ZNF286B	chr17	18569342	+	FOXO3	chr6	109005972	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	FOXO3	0.0210640056888735	0.59
LIHC	FOXO3	0.0238794602578902	0.64
HNSC	FOXO3	0.0284570466750984	0.74

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	FOXO3	0.000507237722975085	0.017
KIRP	FOXO3	0.00633682593695489	0.2
PRAD	FOXO3	0.00731806375817114	0.23
THYM	FOXO3	0.011328010274709	0.34

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0002152	Alloxan Diabetes	2	CTD_human
C0011853	Diabetes Mellitus, Experimental	2	CTD_human
C0038433	Streptozotocin Diabetes	2	CTD_human
C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
C0010606	Adenoid Cystic Carcinoma	1	CTD_human
C0014072	Experimental Autoimmune Encephalomyelitis	1	CTD_human
C0024117	Chronic Obstructive Airway Disease	1	CTD_human
C0028754	Obesity	1	CTD_human
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
C1527303	Chronic Airflow Obstruction	1	CTD_human