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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: QRSL1 (NCBI Gene ID:55278)

Gene Summary

Gene Summary

Gene Information	Gene Name: QRSL1
	Gene ID: 55278
	Gene Symbol	QRSL1
	Gene ID	55278
	Gene Name	glutaminyl-tRNA amidotransferase subunit QRSL1
	Synonyms	GatA
	Cytomap	6q21
	Type of Gene	protein-coding
	Description	glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialQRSL1, glutaminyl-tRNA amidotransferase subunit Aglu-AdT subunit Aglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1glutaminyl-tRNA synthase-like protein 1glutamyl-tRNA(Gln) amidotransf
	Modification date	20200313
	UniProtAcc	Q9H0R6

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	QRSL1	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	19805282

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
QRSL1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'QRSL1[title] AND translation [title] AND human.'

Gene	Title	PMID
QRSL1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000369046	107090868	107090965	Frame-shift
ENST00000369046	107100083	107100259	Frame-shift
ENST00000369046	107102604	107102797	Frame-shift
ENST00000369046	107110854	107111060	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	QRSL1	-1.44147893876616	0.000391133065002894
LUSC	QRSL1	-1.56841516878295	0.00339826502432084
THCA	QRSL1	-3.10847540716222	1.02220761620756e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	QRSL1	hsa-miR-153-5p	89	-0.367150496562261	0.033367879409282

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	QRSL1	0.033346389	0.035361648
STAD	QRSL1	-0.060794545	0.045914897

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with QRSL1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	TSG	QRSL1	PDSS2	0.833727033	1.04E-45
PRAD	Epifactor	QRSL1	HDAC2	0.813104266	7.04E-131
PRAD	IUPHAR	QRSL1	HDAC2	0.813104266	7.04E-131
STAD	TSG	QRSL1	RTN4IP1	0.837856981	7.51E-120
UVM	Cell metabolism gene	QRSL1	NUP43	0.819830964	1.42E-20
UVM	Epifactor	QRSL1	HDAC2	0.850150254	1.97E-23
UVM	IUPHAR	QRSL1	KATNA1	0.839804896	2.17E-22
UVM	IUPHAR	QRSL1	MAP3K4	0.841567267	1.46E-22
UVM	IUPHAR	QRSL1	HDAC2	0.850150254	1.97E-23
UVM	Kinase	QRSL1	MAP3K4	0.841567267	1.46E-22
UVM	TF	QRSL1	TBPL1	0.827969378	2.75E-21
UVM	TF	QRSL1	HSF2	0.874662173	3.02E-26
UVM	TF	QRSL1	TBP	0.877098239	1.47E-26
UVM	TSG	QRSL1	HACE1	0.801671382	4.14E-19
UVM	TSG	QRSL1	PARK2	0.815934753	3.01E-20
UVM	TSG	QRSL1	MAP3K4	0.841567267	1.46E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	QRSL1	GATC	-3.31212457667297	0.000202139908061226
KICH	QRSL1	NARS	1.07442061729154	0.000249803066253662
KIRP	QRSL1	EARS2	2.04485161641576	0.000364991836249828
BRCA	QRSL1	QARS	-4.19270554058168	0.00045278023754438
STAD	QRSL1	EPRS	-1.48171581324647	0.000789262883452143
LUAD	QRSL1	NARS	-1.22666458579243	0.00134906742748461
THCA	QRSL1	QARS	-1.4601543520666	0.00171161769998529
THCA	QRSL1	MRPS34	-1.45441957963461	0.00290442341112608
THCA	QRSL1	GATC	1.7309635515299	0.00553919070100212
PRAD	QRSL1	MRPS34	-5.35106598630245	0.0285087588592711
CHOL	QRSL1	NARS	-7.86696864946951	0.0390625
LUAD	QRSL1	MRPS34	-2.70136571593428	2.07702654013452e-08
LIHC	QRSL1	EPRS	-7.10731017811505	2.28054594243154e-08
KIRC	QRSL1	NARS	-2.40040204492647	2.49674919862186e-10
BRCA	QRSL1	MRPS34	-2.53214434739385	3.14738496193661e-22
LUSC	QRSL1	EARS2	-4.79437223180067	3.23227619897643e-09
PRAD	QRSL1	QARS	1.84374784424986	3.33417295851411e-06
PRAD	QRSL1	WARS2	2.22021907294155	3.33417295851411e-06
LUAD	QRSL1	EARS2	-4.660053370012	3.79251210274868e-11
BLCA	QRSL1	EARS2	-4.74352280775662	3.814697265625e-06
COAD	QRSL1	GATC	2.11115021298901	4.08291816711426e-06
LUSC	QRSL1	MRPS34	-2.71852874741784	4.28240904037329e-08
STAD	QRSL1	EARS2	-1.69983591205674	4.39747236669064e-05
LIHC	QRSL1	NARS	-3.55177423456569	7.34047974405276e-07
PRAD	QRSL1	EPRS	-1.76339127457265	9.52775218277559e-05
STAD	QRSL1	NARS2	-1.47625969382721	9.99853946268559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with QRSL1

KRT8, XRCC6, GATC, GPBP1L1, GATB, USP47, ARSG, MRM1, HSPD1, PDK1, TRMT61B, IMMP2L, GRSF1, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, C8orf82, CS, FASTKD5, GFM1, HINT2, ICT1, LONP1, LRPPRC, MDH2, METTL15, METTL17, MRPL11, MRPS26, MRRF, MTERF3, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, PMPCA, PMPCB, RPUSD4, SSBP1, TACO1, TBRG4, TFAM, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, HSCB, OGT, AARS2, COX8A, PDHA1, TRAP1, APOA2, DOK4, PTCD1, SMAD4, ADCK4, PNPT1, ACAD10, PUS1, SUV39H2, MED17, RSAD1, POLR3K, ALDH4A1, BCKDK, FAHD1, CYP24A1, SLC34A2, FCGRT, ACSF3, ZBTB2, ZNF444, DARS2, TARS2, NDUFA10, CPT2, YTHDF1, GLS, MILR1, CTNNA3, COQ6, CLPX, IVD, ANKRD49, AHR, PHKA2, FPGS, KIAA1279, PPOX, MTHFD1L, SPECC1L, YARS2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
QRSL1	chr6	107077408	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107077502	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
QRSL1	chr6	107077550	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
QRSL1	chr6	107088231	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107088585	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107088768	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
QRSL1	chr6	107088927	TG	T	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107090935	G	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_40	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107096853	A	C	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_40\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107096917	G	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_40\|Cardiomyopathy,_mitochondrial	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107097074	C	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_40\|Cardiomyopathy,_mitochondrial	SO:0001587\|nonsense	SO:0001587\|nonsense
QRSL1	chr6	107097123	AAC	A	Deletion	Benign	Combined_oxidative_phosphorylation_deficiency_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107097273	TTAAAA	T	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107100113	CCAGAAATCC	ACAAAAATCA	Indel	Pathogenic	Cardiomyopathy,_mitochondrial	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107100396	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107100483	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107102600	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107102602	A	G	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107103389	C	CA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107103389	CA	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107103479	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107103537	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107110973	GC	TT	Indel	Pathogenic	Combined_oxidative_phosphorylation_deficiency_40\|Cardiomyopathy,_mitochondrial	SO:0001583\|missense_variant	SO:0001583\|missense_variant
QRSL1	chr6	107111084	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107113403	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107113509	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107113618	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
QRSL1	chr6	107113715	G	A	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_40\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
QRSL1	chr6	107113953	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
QRSL1	chr6	107113963	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
QRSL1	chr6	107113967	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
QRSL1	LIHC	chr6	107088273	107088273	A	-	Frame_Shift_Del	p.Q25fs	4
QRSL1	ESCA	chr6	107096922	107096922	T	G	Missense_Mutation	p.F135V	3
QRSL1	BRCA	chr6	107096913	107096913	G	C	Missense_Mutation	p.D132H	3
QRSL1	BLCA	chr6	107110891	107110891	G	A	Silent		3
QRSL1	LIHC	chr6	107090936	107090936	A	-	Frame_Shift_Del	p.G117fs	3
QRSL1	LIHC	chr6	107113765	107113765	A	G	Missense_Mutation		3
QRSL1	LIHC	chr6	107113765	107113765	A	G	Missense_Mutation	p.K492R	2
QRSL1	LIHC	chr6	107102785	107102785	G	-	Frame_Shift_Del	p.G344fs	2
QRSL1	KIRC	chr6	107088233	107088233	G	A	Missense_Mutation	p.A12T	2
QRSL1	LIHC	chr6	107103591	107103591	T	-	Frame_Shift_Del	p.F383fs	2
QRSL1	ESCA	chr6	107088318	107088318	A	T	Missense_Mutation	p.Y40F	2
QRSL1	CESC	chr6	107103510	107103510	G	T	Missense_Mutation		2
QRSL1	ESCA	chr6	107096922	107096922	T	G	Missense_Mutation		2
QRSL1	UCEC	chr6	107090882	107090882	T	G	Silent	p.P99	2
QRSL1	SKCM	chr6	107100110	107100110	C	T	Missense_Mutation	p.S195L	2
QRSL1	UCEC	chr6	107097074	107097074	C	T	Silent	p.Y185	2
QRSL1	SKCM	chr6	107102704	107102704	C	T	Missense_Mutation	p.L317F	2
QRSL1	STAD	chr6	107096961	107096961	T	A	Missense_Mutation	p.Y148N	2
QRSL1	UCEC	chr6	107100261	107100261	T	C	Splice_Site	e6+2	2
QRSL1	SKCM	chr6	107102665	107102665	C	T	Missense_Mutation	p.L304F	2
QRSL1	STAD	chr6	107088263	107088263	G	A	Missense_Mutation	p.E22K	2
QRSL1	UCEC	chr6	107103537	107103537	A	T	Missense_Mutation	p.T364S	2
QRSL1	SKCM	chr6	107096972	107096972	G	A	Silent	p.K151K	2
QRSL1	STAD	chr6	107111010	107111010	G	T	Missense_Mutation	p.R439I	2
QRSL1	SKCM	chr6	107102635	107102635	G	A	Missense_Mutation	p.V294I	2
QRSL1	LIHC	chr6	107113739	107113739	T	C	Silent		2
QRSL1	SARC	chr6	107113715	107113715	G	A	Silent		2
QRSL1	SKCM	chr6	107088727	107088727	C	T	Missense_Mutation	p.P72S	2
QRSL1	BLCA	chr6	107100203	107100203	C	T	Missense_Mutation	p.S226L	2
QRSL1	COAD	chr6	107110935	107110935	G	C	Missense_Mutation	p.G414A	1
QRSL1	LUAD	chr6	107100454	107100454	A	G	Silent	p.P282P	1
QRSL1	STAD	chr6	107100220	107100220	A	G	Missense_Mutation	p.I232V	1
QRSL1	HNSC	chr6	107090875	107090875	T	C	Missense_Mutation	p.I97T	1
QRSL1	SARC	chr6	107102617	107102617	C	T	Missense_Mutation		1
QRSL1	SKCM	chr6	107102702	107102702	C	T	Missense_Mutation	p.S316F	1
QRSL1	BLCA	chr6	107113690	107113690	C	G	Nonsense_Mutation	p.S467*	1
QRSL1	DLBC	chr6	107100238	107100238	G	A	Missense_Mutation	p.D238N	1
QRSL1	LUAD	chr6	107111060	107111060	G	T	Splice_Site	p.G456_splice	1
QRSL1	THYM	chr6	107103564	107103564	G	T	Missense_Mutation	p.V373L	1
QRSL1	HNSC	chr6	107100173	107100173	C	T	Missense_Mutation	p.S216F	1
QRSL1	SKCM	chr6	107102707	107102707	C	T	Missense_Mutation	p.P318S	1
QRSL1	BLCA	chr6	107096958	107096958	C	T	Nonsense_Mutation	p.Q147*	1
QRSL1	LUAD	chr6	107100441	107100441	G	T	Missense_Mutation	p.C278F	1
QRSL1	THYM	chr6	107102774	107102774	C	A	Missense_Mutation	p.A340E	1
QRSL1	SKCM	chr6	107113789	107113789	T	C	Missense_Mutation	p.F500S	1
QRSL1	BLCA	chr6	107110891	107110891	G	A	Silent	p.V399V	1
QRSL1	LUAD	chr6	107100349	107100349	G	T	Silent	p.L247L	1
QRSL1	UCEC	chr6	107103514	107103514	C	G	Missense_Mutation	p.S356C	1
QRSL1	BLCA	chr6	107088768	107088768	G	T	Missense_Mutation		1
QRSL1	KIRP	chr6	107111042	107111042	C	A	Missense_Mutation	p.Q450K	1
QRSL1	SKCM	chr6	107097034	107097034	C	T	Missense_Mutation	p.S172L	1
QRSL1	LIHC	chr6	107102702	107102702	C	-	Frame_Shift_Del	p.S316fs	1
QRSL1	ESCA	chr6	107100491	107100491	C	T	Silent		1
QRSL1	LUAD	chr6	107100092	107100092	G	T	Missense_Mutation	p.G189V	1
QRSL1	UCEC	chr6	107103504	107103504	A	G	Missense_Mutation	p.I353V	1
QRSL1	BLCA	chr6	107100544	107100544	A	C	Missense_Mutation		1
QRSL1	LGG	chr6	107113856	107113856	C	A	Silent	p.A522A	1
QRSL1	STAD	chr6	107088346	107088346	A	-	Frame_Shift_Del		1
QRSL1	LIHC	chr6	107113840	107113840	A	-	Frame_Shift_Del	p.E517fs	1
QRSL1	LUAD	chr6	107100091	107100091	G	T	Nonsense_Mutation	p.G189*	1
QRSL1	BLCA	chr6	107100203	107100203	C	T	Missense_Mutation		1
QRSL1	LGG	chr6	107113856	107113856	C	A	Silent		1
QRSL1	STAD	chr6	107088346	107088346	A	-	Frame_Shift_Del	p.L49X	1
QRSL1	CESC	chr6	107113761	107113761	G	T	Missense_Mutation		1
QRSL1	ESCA	chr6	107113700	107113700	G	T	Silent	p.G470G	1
QRSL1	LUSC	chr6	107111000	107111000	G	C	Missense_Mutation	p.E436Q	1
QRSL1	LIHC	chr6	107111007	107111007	A	G	Missense_Mutation		1
QRSL1	CESC	chr6	107110891	107110891	G	A	Silent	p.V399	1
QRSL1	ESCA	chr6	107100491	107100491	C	T	Silent	p.L295L	1
QRSL1	LUSC	chr6	107103556	107103556	A	G	Missense_Mutation	p.N370S	1
QRSL1	BLCA	chr6	107110876	107110876	C	A	Silent		1
QRSL1	LIHC	chr6	107103547	107103547	A	G	Missense_Mutation		1
QRSL1	COAD	chr6	107096993	107096993	C	T	Silent	p.S158S	1
QRSL1	LIHC	chr6	107110886	107110886	A	-	Frame_Shift_Del	p.K398fs	1
QRSL1	GBM	chr6	107103543	107103543	C	T	Missense_Mutation		1
QRSL1	PCPG	chr6	107111062	107111062	T	G	Splice_Site		1
QRSL1	BLCA	chr6	107088298	107088298	G	C	Missense_Mutation		1
QRSL1	LUAD	chr6	107110970	107110970	G	A	Missense_Mutation	p.E426K	1
QRSL1	COAD	chr6	107100176	107100176	G	A	Missense_Mutation	p.R217H	1
QRSL1	HNSC	chr6	107090875	107090875	T	C	Missense_Mutation		1
QRSL1	READ	chr6	107103579	107103579	C	A	Missense_Mutation	p.L378I	1
QRSL1	BLCA	chr6	107100544	107100544	A	C	Missense_Mutation	p.E312D	1
QRSL1	COAD	chr6	107100396	107100396	A	G	Missense_Mutation	p.N263S	1
QRSL1	LUAD	chr6	107088379	107088379	G	C	Missense_Mutation	p.K60N	1
QRSL1	STAD	chr6	107088346	107088346	A	-	Frame_Shift_Del	p.L49fs	1
QRSL1	HNSC	chr6	107100173	107100173	C	T	Missense_Mutation		1
QRSL1	LIHC	chr6	107111016	107111016	G	A	Missense_Mutation	p.R441Q	1

Copy number variation (CNV) of QRSL1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across QRSL1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101678	BRCA	TCGA-AN-A04C	ATG5	chr6	106727535	-	QRSL1	chr6	107113656	+
101678	BRCA	TCGA-AN-A04C-01A	ATG5	chr6	106727536	-	QRSL1	chr6	107113657	+
101678	N/A	BF344883	HLA-B	chr6	31321649	-	QRSL1	chr6	107087018	-
101678	STAD	TCGA-VQ-A8DU-01A	IGF2	chr11	2162177	+	QRSL1	chr6	107110855	+
101678	N/A	CA841180	PNISR	chr6	99860426	-	QRSL1	chr6	107100080	+
101678	BRCA	TCGA-E2-A9RU-01A	PREP	chr6	105845728	-	QRSL1	chr6	107088224	+
101678	STAD	TCGA-BR-8373-01A	PVT1	chr8	128806980	+	QRSL1	chr6	107110855	+
101678	STAD	TCGA-BR-8373-01A	PVT1	chr8	128808254	+	QRSL1	chr6	107110855	+
101678	STAD	TCGA-BR-8373-01A	PVT1	chr8	128808317	+	QRSL1	chr6	107110855	+
101678	STAD	TCGA-CD-8528	PVT1	chr8	128806980	+	QRSL1	chr6	107110854	+
101678	STAD	TCGA-CD-8528	PVT1	chr8	128806980	+	QRSL1	chr6	107113656	+
101678	STAD	TCGA-CD-8528-01A	PVT1	chr8	128806980	+	QRSL1	chr6	107110941	+
101678	STAD	TCGA-CD-8528-01A	PVT1	chr8	128829130	+	QRSL1	chr6	107110855	+
82266	BRCA	TCGA-E2-A9RU-01A	QRSL1	chr6	107090965	+	ATG5	chr6	106740981	-
102854	STAD	TCGA-BR-8058-01A	QRSL1	chr6	107077580	+	FAM120B	chr6	170697375	+
102270	STAD	TCGA-CD-8528-01A	QRSL1	chr6	107110882	+	PVT1	chr8	128806788	+
102270	STAD	TCGA-CD-8528-01A	QRSL1	chr6	107110894	+	PVT1	chr8	128806800	+
102270	STAD	TCGA-CD-8528-01A	QRSL1	chr6	107110935	+	PVT1	chr8	128806787	+
102270	STAD	TCGA-CD-8528-01A	QRSL1	chr6	107110988	+	PVT1	chr8	128806787	+
101678	N/A	BE250091	QRSL1	chr6	107100343	-	QRSL1	chr6	107100378	+
101678	LUSC	TCGA-77-A5G6-01A	RTN4IP1	chr6	107076623	-	QRSL1	chr6	107088224	+
101678	STAD	TCGA-BR-8060-01A	RTN4IP1	chr6	107067077	-	QRSL1	chr6	107110855	+
101680	SARC	TCGA-K1-A42X-01A	ZNF236	chr18	74563895	+	QRSL1	chr6	107088224	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	QRSL1	0.00229331620952357	0.064
GBM	QRSL1	0.0161091094752646	0.43
TGCT	QRSL1	0.0289667308406516	0.75
LGG	QRSL1	0.0381536155914892	0.95
BRCA	QRSL1	0.045068599206044	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	QRSL1	0.000261303775899578	0.0086
KIRP	QRSL1	0.0353379150511616	1
LAML	QRSL1	0.0283567892618622	0.85
PRAD	QRSL1	0.0182876331904275	0.57
PAAD	QRSL1	0.0154612846128301	0.49
ESCA	QRSL1	0.0478557086261393	1
THYM	QRSL1	0.042931468052564	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3532239	Mitochondrial cardiomyopathy	1	GENOMICS_ENGLAND