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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL29 (NCBI Gene ID:6159)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL29
	Gene ID: 6159
	Gene Symbol	RPL29
	Gene ID	6159
	Gene Name	ribosomal protein L29
	Synonyms	HIP\|HUMRPL29\|L29\|RPL29P10\|RPL29_3_370
	Cytomap	3p21.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L29HP/HS-interacting proteincell surface heparin-binding protein HIPheparin/heparan sulfate-binding proteinheparin/heparan sulfate-interacting proteinlarge ribosomal subunit protein eL29ribosomal protein YL43 homologue
	Modification date	20200313
	UniProtAcc	P47914

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL29	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL29[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL29	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000294189	52029057	52029122	Frame-shift
ENST00000466397	52029057	52029122	Frame-shift
ENST00000475248	52029057	52029122	Frame-shift
ENST00000479017	52029057	52029122	Frame-shift
ENST00000495383	52029057	52029122	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	RPL29	1.34120891282909	0.00141303901136259
COAD	RPL29	2.01531946700608	0.00390031933784485
STAD	RPL29	-1.21862598776416	0.0227867118082941
KIRP	RPL29	-3.32206918296731	2.00420618057251e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KICH	RPL29	-0.034907138	0.005537738
STAD	RPL29	-0.051944744	0.027776369

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL29 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL29	GEMIN7	0.807768372	3.97E-12
DLBC	Cell metabolism gene	RPL29	PFDN5	0.815598726	1.67E-12
DLBC	Cell metabolism gene	RPL29	NME2	0.834324462	1.76E-13
DLBC	Cell metabolism gene	RPL29	TIMM9	0.860000465	4.90E-15
DLBC	Cell metabolism gene	RPL29	FAU	0.86581473	1.97E-15
DLBC	IUPHAR	RPL29	SLC25A26	0.812648138	2.32E-12
DLBC	TF	RPL29	THAP4	0.800504159	8.56E-12
DLBC	TF	RPL29	THAP3	0.808057003	3.85E-12
DLBC	TF	RPL29	NME2	0.834324462	1.76E-13
DLBC	TSG	RPL29	GADD45GIP1	0.81925308	1.10E-12
DLBC	TSG	RPL29	GNB2L1	0.873928638	5.15E-16
GBM	Cell metabolism gene	RPL29	SSR2	0.807052387	9.61E-41
GBM	Cell metabolism gene	RPL29	SSR4	0.808325507	5.80E-41
HNSC	Cell metabolism gene	RPL29	IMPDH2	0.805543566	2.70E-130
HNSC	IUPHAR	RPL29	IMPDH2	0.805543566	2.70E-130
KICH	Cell metabolism gene	RPL29	SNRPD2	0.873764713	1.32E-29
KIRP	Cell metabolism gene	RPL29	SNRPD2	0.803191732	3.40E-74
KIRP	Cell metabolism gene	RPL29	FAU	0.81880816	2.30E-79
LGG	Cell metabolism gene	RPL29	IMPDH2	0.828693345	3.49E-135
LGG	Cell metabolism gene	RPL29	FAU	0.851562739	3.37E-150
LGG	CGC	RPL29	NACA	0.820511666	2.41E-130
LGG	IUPHAR	RPL29	IMPDH2	0.828693345	3.49E-135
LGG	TSG	RPL29	GNB2L1	0.832698868	1.20E-137
PRAD	Cell metabolism gene	RPL29	SNRPD2	0.803838993	1.00E-125
PRAD	Cell metabolism gene	RPL29	TIMM9	0.810770751	1.49E-129
PRAD	Cell metabolism gene	RPL29	FAU	0.829006822	1.98E-140
PRAD	Cell metabolism gene	RPL29	NME2	0.830197916	3.48E-141
PRAD	CGC	RPL29	NACA	0.862861332	1.61E-164
PRAD	Epifactor	RPL29	FBL	0.821239081	1.20E-135
PRAD	TF	RPL29	ZNF581	0.810317192	2.68E-129
PRAD	TF	RPL29	NME2	0.830197916	3.48E-141
PRAD	TSG	RPL29	GNB2L1	0.907046181	5.00E-208
THCA	Cell metabolism gene	RPL29	DGUOK	0.802859427	3.79E-130
THCA	Cell metabolism gene	RPL29	EXOSC1	0.804556726	4.21E-131
THCA	Cell metabolism gene	RPL29	EXOSC5	0.80695996	1.80E-132
THCA	Cell metabolism gene	RPL29	PGLS	0.807467322	9.23E-133
THCA	Cell metabolism gene	RPL29	POLR2I	0.822075504	1.54E-141
THCA	Cell metabolism gene	RPL29	PFDN5	0.86499534	7.57E-173
THCA	Cell metabolism gene	RPL29	SNRPD2	0.874623451	2.26E-181
THCA	Cell metabolism gene	RPL29	FAU	0.9082787	7.12E-218
THCA	CGC	RPL29	NACA	0.809791693	4.16E-134
THCA	Epifactor	RPL29	TAF10	0.802500671	6.02E-130
THCA	Epifactor	RPL29	EXOSC1	0.804556726	4.21E-131
THCA	Epifactor	RPL29	EXOSC5	0.80695996	1.80E-132
THCA	IUPHAR	RPL29	CSNK2B	0.82595409	5.25E-144
THCA	TF	RPL29	ZNF524	0.801817446	1.45E-129
THCA	TSG	RPL29	GADD45GIP1	0.820117643	2.57E-140
THCA	TSG	RPL29	AIP	0.820317038	1.93E-140
THCA	TSG	RPL29	GNB2L1	0.863507387	1.37E-171
THYM	Cell metabolism gene	RPL29	MIF	0.800340896	1.97E-28
THYM	Cell metabolism gene	RPL29	FPGS	0.801240553	1.55E-28
THYM	Cell metabolism gene	RPL29	DGUOK	0.802164263	1.21E-28
THYM	Cell metabolism gene	RPL29	POLD4	0.803088427	9.38E-29
THYM	Cell metabolism gene	RPL29	TOMM22	0.807409198	2.84E-29
THYM	Cell metabolism gene	RPL29	IDH3G	0.807473131	2.79E-29
THYM	Cell metabolism gene	RPL29	PMPCA	0.808002982	2.41E-29
THYM	Cell metabolism gene	RPL29	MTX1	0.810236	1.28E-29
THYM	Cell metabolism gene	RPL29	PHKG2	0.811896887	7.98E-30
THYM	Cell metabolism gene	RPL29	LSM4	0.812481549	6.74E-30
THYM	Cell metabolism gene	RPL29	TIMM10	0.817264789	1.67E-30
THYM	Cell metabolism gene	RPL29	LSM2	0.817276224	1.66E-30
THYM	Cell metabolism gene	RPL29	MVD	0.81766129	1.48E-30
THYM	Cell metabolism gene	RPL29	SRM	0.817760759	1.44E-30
THYM	Cell metabolism gene	RPL29	IMPDH2	0.819541074	8.44E-31
THYM	Cell metabolism gene	RPL29	GUK1	0.821232257	5.06E-31
THYM	Cell metabolism gene	RPL29	SMPD2	0.82408178	2.11E-31
THYM	Cell metabolism gene	RPL29	POLD2	0.824334447	1.95E-31
THYM	Cell metabolism gene	RPL29	GEMIN6	0.824337836	1.95E-31
THYM	Cell metabolism gene	RPL29	SNRPD3	0.828330828	5.58E-32
THYM	Cell metabolism gene	RPL29	HMBS	0.833669019	9.92E-33
THYM	Cell metabolism gene	RPL29	PSMD13	0.833808554	9.48E-33
THYM	Cell metabolism gene	RPL29	DPM3	0.834689564	7.08E-33
THYM	Cell metabolism gene	RPL29	DPM2	0.834841345	6.73E-33
THYM	Cell metabolism gene	RPL29	POLR2H	0.837900205	2.42E-33
THYM	Cell metabolism gene	RPL29	POLR2J	0.839979685	1.19E-33
THYM	Cell metabolism gene	RPL29	EBP	0.841070137	8.16E-34
THYM	Cell metabolism gene	RPL29	POLR2I	0.841556082	6.90E-34
THYM	Cell metabolism gene	RPL29	EXOSC4	0.845619707	1.65E-34
THYM	Cell metabolism gene	RPL29	POLR2F	0.847733043	7.70E-35
THYM	Cell metabolism gene	RPL29	APRT	0.84781175	7.48E-35
THYM	Cell metabolism gene	RPL29	PSMB7	0.849531523	3.99E-35
THYM	Cell metabolism gene	RPL29	ITPA	0.851202637	2.15E-35
THYM	Cell metabolism gene	RPL29	EXOSC5	0.852183196	1.49E-35
THYM	Cell metabolism gene	RPL29	PSMC3	0.853421813	9.37E-36
THYM	Cell metabolism gene	RPL29	SSR2	0.856938381	2.43E-36
THYM	Cell metabolism gene	RPL29	TIMM50	0.858871391	1.14E-36
THYM	Cell metabolism gene	RPL29	PSMB3	0.860505744	5.98E-37
THYM	Cell metabolism gene	RPL29	ACOT8	0.868998538	1.80E-38
THYM	Cell metabolism gene	RPL29	TIMM13	0.872657941	3.68E-39
THYM	Cell metabolism gene	RPL29	PFDN5	0.877095075	5.02E-40
THYM	Cell metabolism gene	RPL29	PGLS	0.878391129	2.77E-40
THYM	Cell metabolism gene	RPL29	SLC27A5	0.889785938	1.07E-42
THYM	Cell metabolism gene	RPL29	SNRPD2	0.901228941	2.12E-45
THYM	Cell metabolism gene	RPL29	TIMM8B	0.902838987	8.29E-46
THYM	Cell metabolism gene	RPL29	FAU	0.945512386	2.54E-60
THYM	CGC	RPL29	MGMT	0.81048878	1.19E-29
THYM	CGC	RPL29	SDHAF2	0.829611107	3.71E-32
THYM	CGC	RPL29	TFPT	0.831943793	1.74E-32
THYM	CGC	RPL29	RBM10	0.849150059	4.59E-35
THYM	Epifactor	RPL29	LAS1L	0.804977197	5.59E-29
THYM	Epifactor	RPL29	DMAP1	0.808649919	2.01E-29
THYM	Epifactor	RPL29	C17orf49	0.829107491	4.35E-32
THYM	Epifactor	RPL29	PPP4C	0.829439108	3.92E-32
THYM	Epifactor	RPL29	TFPT	0.831943793	1.74E-32
THYM	Epifactor	RPL29	MBD3	0.833272522	1.13E-32
THYM	Epifactor	RPL29	RUVBL2	0.838412118	2.03E-33
THYM	Epifactor	RPL29	SS18L2	0.839366723	1.47E-33
THYM	Epifactor	RPL29	EXOSC4	0.845619707	1.65E-34
THYM	Epifactor	RPL29	NOC2L	0.846206593	1.34E-34
THYM	Epifactor	RPL29	PRPF31	0.848887537	5.06E-35
THYM	Epifactor	RPL29	CCDC101	0.849129919	4.63E-35
THYM	Epifactor	RPL29	EXOSC5	0.852183196	1.49E-35
THYM	Epifactor	RPL29	ZNHIT1	0.855574651	4.12E-36
THYM	Epifactor	RPL29	INO80E	0.865218523	8.80E-38
THYM	Epifactor	RPL29	SIRT6	0.878974407	2.11E-40
THYM	Epifactor	RPL29	FBL	0.880855065	8.74E-41
THYM	Epifactor	RPL29	BRMS1	0.886531869	5.56E-42
THYM	Epifactor	RPL29	TAF10	0.906608713	8.66E-47
THYM	IUPHAR	RPL29	SIRT3	0.808353674	2.18E-29
THYM	IUPHAR	RPL29	PHKG2	0.811896887	7.98E-30
THYM	IUPHAR	RPL29	MVD	0.81766129	1.48E-30
THYM	IUPHAR	RPL29	IMPDH2	0.819541074	8.44E-31
THYM	IUPHAR	RPL29	SMPD2	0.82408178	2.11E-31
THYM	IUPHAR	RPL29	SIRT6	0.878974407	2.11E-40
THYM	IUPHAR	RPL29	SLC27A5	0.889785938	1.07E-42
THYM	Kinase	RPL29	PHKG2	0.811896887	7.98E-30
THYM	TF	RPL29	RBCK1	0.80114276	1.59E-28
THYM	TF	RPL29	DRAP1	0.802592686	1.07E-28
THYM	TF	RPL29	THYN1	0.803184697	9.13E-29
THYM	TF	RPL29	ZBTB48	0.814972558	3.27E-30
THYM	TF	RPL29	ZNF581	0.820757061	5.85E-31
THYM	TF	RPL29	ZNF688	0.825181874	1.50E-31
THYM	TF	RPL29	ETV2	0.826872882	8.85E-32
THYM	TF	RPL29	THAP3	0.827086007	8.27E-32
THYM	TF	RPL29	THAP7	0.832614769	1.40E-32
THYM	TF	RPL29	MBD3	0.833272522	1.13E-32
THYM	TF	RPL29	ZNF428	0.837620223	2.66E-33
THYM	TF	RPL29	ZNF787	0.842856763	4.38E-34
THYM	TSG	RPL29	SIRT3	0.808353674	2.18E-29
THYM	TSG	RPL29	PARK7	0.81140523	9.19E-30
THYM	TSG	RPL29	AIP	0.812666124	6.39E-30
THYM	TSG	RPL29	ZBTB48	0.814972558	3.27E-30
THYM	TSG	RPL29	GADD45GIP1	0.866848475	4.46E-38
THYM	TSG	RPL29	TSSC4	0.873215696	2.87E-39
THYM	TSG	RPL29	NPRL2	0.873311792	2.75E-39
THYM	TSG	RPL29	SIRT6	0.878974407	2.11E-40
THYM	TSG	RPL29	GLTSCR2	0.879079594	2.01E-40
THYM	TSG	RPL29	BRMS1	0.886531869	5.56E-42
THYM	TSG	RPL29	GNB2L1	0.895488124	5.27E-44
UCS	Cell metabolism gene	RPL29	MIF	0.800340896	1.97E-28
UCS	Cell metabolism gene	RPL29	FPGS	0.801240553	1.55E-28
UCS	Cell metabolism gene	RPL29	DGUOK	0.802164263	1.21E-28
UCS	Cell metabolism gene	RPL29	POLD4	0.803088427	9.38E-29
UCS	Cell metabolism gene	RPL29	TOMM22	0.807409198	2.84E-29
UCS	Cell metabolism gene	RPL29	IDH3G	0.807473131	2.79E-29
UCS	Cell metabolism gene	RPL29	PMPCA	0.808002982	2.41E-29
UCS	Cell metabolism gene	RPL29	MTX1	0.810236	1.28E-29
UCS	Cell metabolism gene	RPL29	PHKG2	0.811896887	7.98E-30
UCS	Cell metabolism gene	RPL29	LSM4	0.812481549	6.74E-30
UCS	Cell metabolism gene	RPL29	TIMM10	0.817264789	1.67E-30
UCS	Cell metabolism gene	RPL29	LSM2	0.817276224	1.66E-30
UCS	Cell metabolism gene	RPL29	MVD	0.81766129	1.48E-30
UCS	Cell metabolism gene	RPL29	SRM	0.817760759	1.44E-30
UCS	Cell metabolism gene	RPL29	IMPDH2	0.819541074	8.44E-31
UCS	Cell metabolism gene	RPL29	GUK1	0.821232257	5.06E-31
UCS	Cell metabolism gene	RPL29	SMPD2	0.82408178	2.11E-31
UCS	Cell metabolism gene	RPL29	POLD2	0.824334447	1.95E-31
UCS	Cell metabolism gene	RPL29	GEMIN6	0.824337836	1.95E-31
UCS	Cell metabolism gene	RPL29	SNRPD3	0.828330828	5.58E-32
UCS	Cell metabolism gene	RPL29	HMBS	0.833669019	9.92E-33
UCS	Cell metabolism gene	RPL29	PSMD13	0.833808554	9.48E-33
UCS	Cell metabolism gene	RPL29	DPM3	0.834689564	7.08E-33
UCS	Cell metabolism gene	RPL29	DPM2	0.834841345	6.73E-33
UCS	Cell metabolism gene	RPL29	POLR2H	0.837900205	2.42E-33
UCS	Cell metabolism gene	RPL29	POLR2J	0.839979685	1.19E-33
UCS	Cell metabolism gene	RPL29	EBP	0.841070137	8.16E-34
UCS	Cell metabolism gene	RPL29	POLR2I	0.841556082	6.90E-34
UCS	Cell metabolism gene	RPL29	EXOSC4	0.845619707	1.65E-34
UCS	Cell metabolism gene	RPL29	POLR2F	0.847733043	7.70E-35
UCS	Cell metabolism gene	RPL29	APRT	0.84781175	7.48E-35
UCS	Cell metabolism gene	RPL29	PSMB7	0.849531523	3.99E-35
UCS	Cell metabolism gene	RPL29	ITPA	0.851202637	2.15E-35
UCS	Cell metabolism gene	RPL29	EXOSC5	0.852183196	1.49E-35
UCS	Cell metabolism gene	RPL29	PSMC3	0.853421813	9.37E-36
UCS	Cell metabolism gene	RPL29	SSR2	0.856938381	2.43E-36
UCS	Cell metabolism gene	RPL29	TIMM50	0.858871391	1.14E-36
UCS	Cell metabolism gene	RPL29	PSMB3	0.860505744	5.98E-37
UCS	Cell metabolism gene	RPL29	ACOT8	0.868998538	1.80E-38
UCS	Cell metabolism gene	RPL29	TIMM13	0.872657941	3.68E-39
UCS	Cell metabolism gene	RPL29	PFDN5	0.877095075	5.02E-40
UCS	Cell metabolism gene	RPL29	PGLS	0.878391129	2.77E-40
UCS	Cell metabolism gene	RPL29	SLC27A5	0.889785938	1.07E-42
UCS	Cell metabolism gene	RPL29	SNRPD2	0.901228941	2.12E-45
UCS	Cell metabolism gene	RPL29	TIMM8B	0.902838987	8.29E-46
UCS	Cell metabolism gene	RPL29	FAU	0.945512386	2.54E-60
UCS	CGC	RPL29	MGMT	0.81048878	1.19E-29
UCS	CGC	RPL29	SDHAF2	0.829611107	3.71E-32
UCS	CGC	RPL29	TFPT	0.831943793	1.74E-32
UCS	CGC	RPL29	RBM10	0.849150059	4.59E-35
UCS	Epifactor	RPL29	LAS1L	0.804977197	5.59E-29
UCS	Epifactor	RPL29	DMAP1	0.808649919	2.01E-29
UCS	Epifactor	RPL29	C17orf49	0.829107491	4.35E-32
UCS	Epifactor	RPL29	PPP4C	0.829439108	3.92E-32
UCS	Epifactor	RPL29	TFPT	0.831943793	1.74E-32
UCS	Epifactor	RPL29	MBD3	0.833272522	1.13E-32
UCS	Epifactor	RPL29	RUVBL2	0.838412118	2.03E-33
UCS	Epifactor	RPL29	SS18L2	0.839366723	1.47E-33
UCS	Epifactor	RPL29	EXOSC4	0.845619707	1.65E-34
UCS	Epifactor	RPL29	NOC2L	0.846206593	1.34E-34
UCS	Epifactor	RPL29	PRPF31	0.848887537	5.06E-35
UCS	Epifactor	RPL29	CCDC101	0.849129919	4.63E-35
UCS	Epifactor	RPL29	EXOSC5	0.852183196	1.49E-35
UCS	Epifactor	RPL29	ZNHIT1	0.855574651	4.12E-36
UCS	Epifactor	RPL29	INO80E	0.865218523	8.80E-38
UCS	Epifactor	RPL29	SIRT6	0.878974407	2.11E-40
UCS	Epifactor	RPL29	FBL	0.880855065	8.74E-41
UCS	Epifactor	RPL29	BRMS1	0.886531869	5.56E-42
UCS	Epifactor	RPL29	TAF10	0.906608713	8.66E-47
UCS	IUPHAR	RPL29	SIRT3	0.808353674	2.18E-29
UCS	IUPHAR	RPL29	PHKG2	0.811896887	7.98E-30
UCS	IUPHAR	RPL29	MVD	0.81766129	1.48E-30
UCS	IUPHAR	RPL29	IMPDH2	0.819541074	8.44E-31
UCS	IUPHAR	RPL29	SMPD2	0.82408178	2.11E-31
UCS	IUPHAR	RPL29	SIRT6	0.878974407	2.11E-40
UCS	IUPHAR	RPL29	SLC27A5	0.889785938	1.07E-42
UCS	Kinase	RPL29	PHKG2	0.811896887	7.98E-30
UCS	TF	RPL29	RBCK1	0.80114276	1.59E-28
UCS	TF	RPL29	DRAP1	0.802592686	1.07E-28
UCS	TF	RPL29	THYN1	0.803184697	9.13E-29
UCS	TF	RPL29	ZBTB48	0.814972558	3.27E-30
UCS	TF	RPL29	ZNF581	0.820757061	5.85E-31
UCS	TF	RPL29	ZNF688	0.825181874	1.50E-31
UCS	TF	RPL29	ETV2	0.826872882	8.85E-32
UCS	TF	RPL29	THAP3	0.827086007	8.27E-32
UCS	TF	RPL29	THAP7	0.832614769	1.40E-32
UCS	TF	RPL29	MBD3	0.833272522	1.13E-32
UCS	TF	RPL29	ZNF428	0.837620223	2.66E-33
UCS	TF	RPL29	ZNF787	0.842856763	4.38E-34
UCS	TSG	RPL29	SIRT3	0.808353674	2.18E-29
UCS	TSG	RPL29	PARK7	0.81140523	9.19E-30
UCS	TSG	RPL29	AIP	0.812666124	6.39E-30
UCS	TSG	RPL29	ZBTB48	0.814972558	3.27E-30
UCS	TSG	RPL29	GADD45GIP1	0.866848475	4.46E-38
UCS	TSG	RPL29	TSSC4	0.873215696	2.87E-39
UCS	TSG	RPL29	NPRL2	0.873311792	2.75E-39
UCS	TSG	RPL29	SIRT6	0.878974407	2.11E-40
UCS	TSG	RPL29	GLTSCR2	0.879079594	2.01E-40
UCS	TSG	RPL29	BRMS1	0.886531869	5.56E-42
UCS	TSG	RPL29	GNB2L1	0.895488124	5.27E-44
UVM	Cell metabolism gene	RPL29	GMDS	0.802241873	3.74E-19
UVM	Cell metabolism gene	RPL29	MPST	0.802908535	3.33E-19
UVM	Cell metabolism gene	RPL29	SLC27A5	0.820315684	1.29E-20
UVM	Cell metabolism gene	RPL29	IMPDH2	0.824451538	5.64E-21
UVM	Cell metabolism gene	RPL29	SSR2	0.828042534	2.71E-21
UVM	Cell metabolism gene	RPL29	POLR2H	0.834055217	7.63E-22
UVM	Cell metabolism gene	RPL29	FAU	0.886415725	8.18E-28
UVM	Epifactor	RPL29	FBL	0.904369336	1.41E-30
UVM	IUPHAR	RPL29	MPST	0.802908535	3.33E-19
UVM	IUPHAR	RPL29	SLC27A5	0.820315684	1.29E-20
UVM	IUPHAR	RPL29	IMPDH2	0.824451538	5.64E-21
UVM	TF	RPL29	REXO4	0.848153408	3.17E-23
UVM	TF	RPL29	ZNF581	0.861148539	1.25E-24
UVM	TSG	RPL29	GLTSCR2	0.822568541	8.23E-21
UVM	TSG	RPL29	GNB2L1	0.834112311	7.54E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL29	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL29	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL29	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL29	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL29	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL29	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL29	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL29	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL29	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL29	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL29	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL29	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL29	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL29	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL29	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL29	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL29	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL29	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL29	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL29	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL29	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL29	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL29	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL29	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL29	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL29	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL29	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL29	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL29

PSTPIP1, DDX56, SYBU, CHD3, BLMH, POU5F1, RPL6, RPL12, RPL23A, RPL5, RPL8, RPL9, RPS15A, RPS23, RPS26, RPSA, RPL14, RPS3, RPL21, RPL4, RPL10A, RPS12, RPS6, RPS3A, RPS16, RPS20, RPS2, RPL7A, RPL17, RPS24, RPL32, RPL38, ILF3, EIF5, EIF4B, RPLP0P6, DES, BTF3, SLC9A3R2, NOC4L, HSP90AA1, ESR1, MDC1, FN1, IL7R, UBL4A, PAN2, PSMC5, STAU1, CUL7, EED, RNF2, RPLP1, RPS25, RPS4X, NTRK1, EWSR1, gag, HIST1H3E, NPM1, RPL10, FBXW7, RC3H1, CDH1, MECP2, RRS1, RPL37A, CYLD, BRCA1, MAP2K3, CUL4B, PYHIN1, LARP1, RNF4, LARP7, RNF31, SPDL1, RIOK1, MEPCE, SNAI1, AGR2, RECQL4, ZBTB38, REST, MYC, HIST1H3A, VCP, RC3H2, ATG16L1, PHB, RBX1, NR2C2, PPP1CC, VRK1, HIST1H4A, SNRNP70, ITFG1, ARAF, HMGB1, BIRC3, LMBR1L, NFX1, WWP2, PINK1, WHSC1, FANCD2, HCVgp1, ZC3H18, CDC42, MAP2K1, PTPN6, DDX18, RPL7, SNIP1, N, nsp2, nsp8, ORF7a, UBR5, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF23, PRC1, MKI67, INS, BRD4, Apc2, RBM39, FBP1, LGALS9, GSK3A, RIN3, JADE1, SETD7, SP100, LIN28A, RPL36, PRPF38A, ZMYND11, METTL17, SUV420H2, SPOP, TRIM37, PARK2, UFL1, DDRGK1, TP53, HTRA4, PAGE4, NUDCD2, NAA40, PPID, CUEDC2, H1FOO, ADARB1, RPL7L1, RBM4B, IL17B, SRSF6, NLRP7, FBXO32, CCNF,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL29	KIRP	chr3	52029445	52029445	G	A	Silent	p.N11N	4
RPL29	BRCA	chr3	52027853	52027854	-	CCTTGG	In_Frame_Ins	p.131in_frame_insAK	3
RPL29	BLCA	chr3	52028115	52028115	G	A	Missense_Mutation	p.R44C	2
RPL29	STAD	chr3	52027960	52027960	T	G	Silent	p.R95R	2
RPL29	UCEC	chr3	52028040	52028040	C	T	Missense_Mutation	p.A69T	2
RPL29	UCEC	chr3	52028047	52028047	A	G	Silent	p.S66	2
RPL29	UCEC	chr3	52029107	52029107	C	T	Missense_Mutation	p.R18K	2
RPL29	SKCM	chr3	52027815	52027815	G	A	Missense_Mutation	p.P144S	2
RPL29	BLCA	chr3	52027803	52027803	G	C	Missense_Mutation	p.P148A	2
RPL29	STAD	chr3	52027925	52027925	C	T	Missense_Mutation	p.R107H	2
RPL29	KIRP	chr3	52028143	52028143	C	A	Splice_Site		1
RPL29	STAD	chr3	52027854	52027865	CCTTGGCCTTGG	-	In_Frame_Del	p.127_131del	1
RPL29	LGG	chr3	52029074	52029074	T	C	Missense_Mutation	p.Y29C	1
RPL29	CESC	chr3	52027809	52027809	G	A	Nonsense_Mutation	p.Q146*	1
RPL29	LGG	chr3	52028026	52028026	C	T	Silent	p.K73K	1
RPL29	STAD	chr3	52027966	52027966	G	A	Silent	p.L93L	1
RPL29	CESC	chr3	52027880	52027880	T	-	Frame_Shift_Del	p.K122fs	1
RPL29	LIHC	chr3	52028106	52028106	T	C	Missense_Mutation	p.K47E	1
RPL29	THYM	chr3	52028090	52028090	T	-	Frame_Shift_Del	p.K52fs	1
RPL29	ESCA	chr3	52027882	52027882	T	G	Silent	p.P121	1
RPL29	LIHC	chr3	52029461	52029461	T	-	Frame_Shift_Del	p.N6fs	1
RPL29	ESCA	chr3	52027882	52027882	T	G	Silent	p.P121P	1
RPL29	LIHC	chr3	52029057	52029057	C	-	Frame_Shift_Del	p.V35fs	1
RPL29	HNSC	chr3	52029004	52029004	G	A	Silent		1
RPL29	LUAD	chr3	52029475	52029475	C	T	Translation_Start_Site	p.M1I	1
RPL29	HNSC	chr3	52028994	52028994	G	A	Missense_Mutation		1
RPL29	PRAD	chr3	52027888	52027888	G	A	Silent	p.C119C	1
RPL29	BLCA	chr3	52027803	52027803	G	C	Missense_Mutation		1
RPL29	KIRP	chr3	52027876	52027876	G	T	Silent	p.A123A	1
RPL29	SKCM	chr3	52027863	52027863	T	G	Missense_Mutation	p.K128Q	1
RPL29	KIRP	chr3	52029445	52029445	G	A	Silent		1

Copy number variation (CNV) of RPL29
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL29
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
84924	N/A	AA078812	AIM1	chr6	106911076	-	RPL29	chr3	52027644	+
84924	N/A	AW860778	CD74	chr5	149786889	+	RPL29	chr3	52029930	-
84924	N/A	AW059704	CTSG	chr14	25042799	+	RPL29	chr3	52027789	+
84924	N/A	DA378405	GAS5	chr1	173834490	-	RPL29	chr3	52029909	-
84924	COAD	TCGA-AA-A03F-01A	IGHA2	chr14	106054630	-	RPL29	chr3	52027835	-
84924	N/A	AA469290	MYO5B	chr18	47575391	-	RPL29	chr3	52027644	+
84924	STAD	TCGA-CD-8529-01A	PCBP4	chr3	52001342	-	RPL29	chr3	52029918	-
84924	HNSC	TCGA-CR-7371-01A	ROCK1	chr18	18690779	-	RPL29	chr3	52029896	-
76410	UCEC	TCGA-D1-A3JQ-01A	RPL29	chr3	52027746	-	ACY1	chr3	52020220	+
76410	UCEC	TCGA-D1-A3JQ-01A	RPL29	chr3	52029058	-	ACY1	chr3	52020271	+
85062	N/A	BP429514	RPL29	chr3	52027646	-	AIM1	chr6	106911076	+
78482	N/A	BI859217	RPL29	chr3	52027644	-	ARL5B	chr10	18951751	-
92497	N/A	BI856281	RPL29	chr3	52027644	-	CANX	chr5	179139930	-
96372	N/A	AA533940	RPL29	chr3	52028875	-	CSNK1A1	chr5	148925385	-
76410	N/A	BG576633	RPL29	chr3	52027644	-	CTD-2532K18.1	chr5	174275295	-
94346	N/A	BF342051	RPL29	chr3	52027644	-	KCNB1	chr20	47915469	-
97464	N/A	BG029929	RPL29	chr3	52027644	-	MLH1	chr3	37057958	-
97464	N/A	BG030047	RPL29	chr3	52027648	-	MLH1	chr3	37057903	-
97464	N/A	BG033510	RPL29	chr3	52027644	-	MLH1	chr3	37058099	-
97464	N/A	BG576518	RPL29	chr3	52027644	-	MLH1	chr3	37057932	-
97464	N/A	BG577028	RPL29	chr3	52027646	-	MLH1	chr3	37057932	-
97464	N/A	BI855671	RPL29	chr3	52027644	-	MLH1	chr3	37057916	-
97464	N/A	BI856902	RPL29	chr3	52027644	-	MLH1	chr3	37057914	-
97464	N/A	BI857810	RPL29	chr3	52027644	-	MLH1	chr3	37057966	-
97464	N/A	BM016560	RPL29	chr3	52027646	-	MLH1	chr3	37057966	-
88068	N/A	BG033592	RPL29	chr3	52027623	-	NNT	chr5	43666765	-
77202	N/A	AA522749	RPL29	chr3	52027644	-	PTPN21	chr14	89013639	+
84924	N/A	AA628072	RPL29	chr3	52027735	+	RPL29	chr3	52027792	-
97086	N/A	BF340887	RPL29	chr3	52027637	-	SLC35F1	chr6	118320109	+
97086	N/A	EC550995	RPL29	chr3	52027711	-	SLC35F1	chr6	118320590	+
96860	N/A	BM015530	RPL29	chr3	52027644	-	TEX2	chr17	62285717	-
84924	N/A	AA651739	SLC35F1	chr6	118320584	-	RPL29	chr3	52027735	-
84924	Non-Cancer	TCGA-IP-7968-11A	SNX22	chr15	64448134	+	RPL29	chr3	52027831	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL29	0.000211461758566544	0.0059
SARC	RPL29	0.0277845691676715	0.75
MESO	RPL29	0.0479744281151289	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL29	0.00183523601407257	0.061
PAAD	RPL29	0.00303838651606443	0.097
THYM	RPL29	0.0373972366348469	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source