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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL37A (NCBI Gene ID:6168)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL37A
	Gene ID: 6168
	Gene Symbol	RPL37A
	Gene ID	6168
	Gene Name	ribosomal protein L37a
	Synonyms	L37A
	Cytomap	2q35
	Type of Gene	protein-coding
	Description	60S ribosomal protein L37alarge ribosomal subunit protein eL43
	Modification date	20200313
	UniProtAcc	P61513

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL37A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL37A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL37A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RPL37A	-1.65819510661681	0.00176054927351573
KIRC	RPL37A	-1.68948520020686	2.40126365595523e-09
KIRP	RPL37A	-1.08756830326799	4.39747236669064e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL37A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPL37A	SNRPD2	0.815930838	8.59E-12
CHOL	CGC	RPL37A	NACA	0.825301853	3.09E-12
CHOL	Epifactor	RPL37A	FBL	0.837808435	7.14E-13
DLBC	Cell metabolism gene	RPL37A	PSMB3	0.80056886	8.50E-12
DLBC	Cell metabolism gene	RPL37A	PTDSS2	0.802360574	7.05E-12
DLBC	Cell metabolism gene	RPL37A	POLR2L	0.803558781	6.22E-12
DLBC	Cell metabolism gene	RPL37A	TBCA	0.805711317	4.95E-12
DLBC	Cell metabolism gene	RPL37A	SNRPD3	0.810657817	2.90E-12
DLBC	Cell metabolism gene	RPL37A	TIMM13	0.812109594	2.47E-12
DLBC	Cell metabolism gene	RPL37A	GEMIN7	0.821649634	8.30E-13
DLBC	Cell metabolism gene	RPL37A	HSCB	0.823722458	6.50E-13
DLBC	Cell metabolism gene	RPL37A	TIMM9	0.827438297	4.15E-13
DLBC	Cell metabolism gene	RPL37A	GFER	0.829132705	3.38E-13
DLBC	Cell metabolism gene	RPL37A	POLR2F	0.834797293	1.66E-13
DLBC	Cell metabolism gene	RPL37A	PFDN4	0.839128989	9.46E-14
DLBC	Cell metabolism gene	RPL37A	TOMM22	0.862361644	3.40E-15
DLBC	Cell metabolism gene	RPL37A	PFDN5	0.878016893	2.52E-16
DLBC	Cell metabolism gene	RPL37A	FAU	0.883061694	1.01E-16
DLBC	Cell metabolism gene	RPL37A	NME2	0.883399616	9.49E-17
DLBC	Cell metabolism gene	RPL37A	SNRPD2	0.891855312	1.85E-17
DLBC	CGC	RPL37A	NACA	0.889927781	2.71E-17
DLBC	Epifactor	RPL37A	FBL	0.840508307	7.88E-14
DLBC	TF	RPL37A	THAP7	0.804842246	5.43E-12
DLBC	TF	RPL37A	ZNF444	0.805412399	5.11E-12
DLBC	TF	RPL37A	THAP4	0.827180715	4.29E-13
DLBC	TF	RPL37A	NME2	0.883399616	9.49E-17
DLBC	TSG	RPL37A	HINT1	0.816246241	1.55E-12
DLBC	TSG	RPL37A	PARK7	0.837698799	1.14E-13
DLBC	TSG	RPL37A	GADD45GIP1	0.852822735	1.43E-14
DLBC	TSG	RPL37A	GNB2L1	0.917181327	5.28E-20
GBM	Cell metabolism gene	RPL37A	PSMB4	0.800601376	1.17E-39
GBM	Cell metabolism gene	RPL37A	PFDN5	0.806494588	1.20E-40
GBM	Cell metabolism gene	RPL37A	CCT4	0.80731792	8.65E-41
GBM	Cell metabolism gene	RPL37A	SSR4	0.81199832	1.33E-41
GBM	Cell metabolism gene	RPL37A	SSR2	0.818922617	7.49E-43
GBM	Cell metabolism gene	RPL37A	FAU	0.838208609	1.25E-46
GBM	TSG	RPL37A	GAS5	0.862912527	2.89E-52
HNSC	Cell metabolism gene	RPL37A	PFDN5	0.801916083	2.82E-128
KIRP	Cell metabolism gene	RPL37A	SNRPD2	0.808243472	8.15E-76
LGG	Cell metabolism gene	RPL37A	FAU	0.855218076	7.81E-153
LGG	CGC	RPL37A	NACA	0.828155249	7.40E-135
LGG	TSG	RPL37A	GAS5	0.850285825	2.70E-149
LIHC	Cell metabolism gene	RPL37A	PFDN5	0.821820774	6.55E-105
PCPG	Cell metabolism gene	RPL37A	PFDN5	0.851374013	9.97E-54
PCPG	TSG	RPL37A	GNB2L1	0.810658439	7.13E-45
PRAD	Cell metabolism gene	RPL37A	SNRPE	0.803355209	1.83E-125
PRAD	Cell metabolism gene	RPL37A	POLR2H	0.805807869	8.49E-127
PRAD	Cell metabolism gene	RPL37A	TIMM13	0.82174813	5.95E-136
PRAD	Cell metabolism gene	RPL37A	TIMM9	0.823129662	8.67E-137
PRAD	Cell metabolism gene	RPL37A	POLR2F	0.834386363	6.91E-144
PRAD	Cell metabolism gene	RPL37A	NME2	0.834649025	4.65E-144
PRAD	Cell metabolism gene	RPL37A	POLR2I	0.837936103	3.09E-146
PRAD	Cell metabolism gene	RPL37A	TOMM7	0.839695789	2.01E-147
PRAD	Cell metabolism gene	RPL37A	PSMB7	0.841778229	7.60E-149
PRAD	Cell metabolism gene	RPL37A	FAU	0.863749602	3.09E-165
PRAD	Cell metabolism gene	RPL37A	SNRPD2	0.885639704	1.07E-184
PRAD	CGC	RPL37A	NACA	0.836052263	5.54E-145
PRAD	Epifactor	RPL37A	FBL	0.864817262	4.19E-166
PRAD	TF	RPL37A	ZNF524	0.822037892	3.98E-136
PRAD	TF	RPL37A	NME2	0.834649025	4.65E-144
PRAD	TSG	RPL37A	GAS5	0.819457418	1.40E-134
PRAD	TSG	RPL37A	GNB2L1	0.861758573	1.23E-163
THCA	Cell metabolism gene	RPL37A	PFDN5	0.80910668	1.04E-133
THCA	Cell metabolism gene	RPL37A	SNRPD2	0.842228554	4.56E-155
THCA	Cell metabolism gene	RPL37A	FAU	0.842640298	2.31E-155
THCA	TSG	RPL37A	GNB2L1	0.811261867	5.74E-135
THYM	Cell metabolism gene	RPL37A	MMAB	0.800682485	1.80E-28
THYM	Cell metabolism gene	RPL37A	SMPD2	0.800913491	1.69E-28
THYM	Cell metabolism gene	RPL37A	GUK1	0.804636286	6.14E-29
THYM	Cell metabolism gene	RPL37A	DPM3	0.804721854	5.99E-29
THYM	Cell metabolism gene	RPL37A	PSMB1	0.805280949	5.14E-29
THYM	Cell metabolism gene	RPL37A	GMPPA	0.807644081	2.66E-29
THYM	Cell metabolism gene	RPL37A	MTX1	0.808325252	2.20E-29
THYM	Cell metabolism gene	RPL37A	POLD2	0.808341522	2.19E-29
THYM	Cell metabolism gene	RPL37A	PMPCA	0.80982706	1.44E-29
THYM	Cell metabolism gene	RPL37A	POLR2J	0.810432974	1.21E-29
THYM	Cell metabolism gene	RPL37A	NT5C	0.812607548	6.50E-30
THYM	Cell metabolism gene	RPL37A	TIMM10	0.812927264	5.93E-30
THYM	Cell metabolism gene	RPL37A	MVD	0.813878647	4.50E-30
THYM	Cell metabolism gene	RPL37A	TOMM7	0.815722917	2.63E-30
THYM	Cell metabolism gene	RPL37A	HMBS	0.818537639	1.14E-30
THYM	Cell metabolism gene	RPL37A	PSMD13	0.819367202	8.90E-31
THYM	Cell metabolism gene	RPL37A	TOMM22	0.82074993	5.86E-31
THYM	Cell metabolism gene	RPL37A	SNRPD3	0.82077846	5.81E-31
THYM	Cell metabolism gene	RPL37A	PSMC5	0.822669152	3.27E-31
THYM	Cell metabolism gene	RPL37A	LCMT1	0.824765479	1.71E-31
THYM	Cell metabolism gene	RPL37A	EXOSC5	0.824993241	1.59E-31
THYM	Cell metabolism gene	RPL37A	LSM2	0.826681705	9.40E-32
THYM	Cell metabolism gene	RPL37A	TALDO1	0.82820852	5.80E-32
THYM	Cell metabolism gene	RPL37A	GFER	0.828936749	4.60E-32
THYM	Cell metabolism gene	RPL37A	IMPDH2	0.831367419	2.10E-32
THYM	Cell metabolism gene	RPL37A	APRT	0.834432754	7.71E-33
THYM	Cell metabolism gene	RPL37A	PSMC3	0.842349976	5.23E-34
THYM	Cell metabolism gene	RPL37A	POLR2F	0.842502087	4.96E-34
THYM	Cell metabolism gene	RPL37A	ITPA	0.843136261	3.97E-34
THYM	Cell metabolism gene	RPL37A	TIMM50	0.843448489	3.56E-34
THYM	Cell metabolism gene	RPL37A	PSMB3	0.844292989	2.64E-34
THYM	Cell metabolism gene	RPL37A	POLR2H	0.845164397	1.94E-34
THYM	Cell metabolism gene	RPL37A	ACOT8	0.845713646	1.59E-34
THYM	Cell metabolism gene	RPL37A	POLR2I	0.848068838	6.82E-35
THYM	Cell metabolism gene	RPL37A	EXOSC4	0.849517246	4.01E-35
THYM	Cell metabolism gene	RPL37A	PSMB7	0.859403551	9.27E-37
THYM	Cell metabolism gene	RPL37A	DPM2	0.865854029	6.76E-38
THYM	Cell metabolism gene	RPL37A	PGLS	0.870808604	8.24E-39
THYM	Cell metabolism gene	RPL37A	TIMM13	0.883179805	2.88E-41
THYM	Cell metabolism gene	RPL37A	TIMM8B	0.889953709	9.83E-43
THYM	Cell metabolism gene	RPL37A	SSR2	0.890629125	6.94E-43
THYM	Cell metabolism gene	RPL37A	SLC27A5	0.896950428	2.37E-44
THYM	Cell metabolism gene	RPL37A	SNRPD2	0.897385856	1.86E-44
THYM	Cell metabolism gene	RPL37A	PFDN5	0.909532562	1.40E-47
THYM	Cell metabolism gene	RPL37A	FAU	0.92780254	3.22E-53
THYM	CGC	RPL37A	TFPT	0.817904382	1.38E-30
THYM	CGC	RPL37A	SDHAF2	0.830937397	2.42E-32
THYM	CGC	RPL37A	RBM10	0.831676607	1.90E-32
THYM	Epifactor	RPL37A	INO80E	0.801894436	1.30E-28
THYM	Epifactor	RPL37A	DMAP1	0.80617422	4.01E-29
THYM	Epifactor	RPL37A	PPP4C	0.806238946	3.94E-29
THYM	Epifactor	RPL37A	RUVBL2	0.807206709	3.01E-29
THYM	Epifactor	RPL37A	TFPT	0.817904382	1.38E-30
THYM	Epifactor	RPL37A	RRP8	0.82013446	7.06E-31
THYM	Epifactor	RPL37A	EXOSC5	0.824993241	1.59E-31
THYM	Epifactor	RPL37A	C17orf49	0.826983778	8.54E-32
THYM	Epifactor	RPL37A	NOC2L	0.829000812	4.51E-32
THYM	Epifactor	RPL37A	MBD3	0.830442533	2.84E-32
THYM	Epifactor	RPL37A	ZNHIT1	0.83390354	9.18E-33
THYM	Epifactor	RPL37A	EXOSC4	0.849517246	4.01E-35
THYM	Epifactor	RPL37A	PRPF31	0.849650107	3.82E-35
THYM	Epifactor	RPL37A	SIRT6	0.855449098	4.33E-36
THYM	Epifactor	RPL37A	TAF10	0.862075811	3.18E-37
THYM	Epifactor	RPL37A	BRMS1	0.864977485	9.73E-38
THYM	Epifactor	RPL37A	FBL	0.917128092	9.16E-50
THYM	IUPHAR	RPL37A	SMPD2	0.800913491	1.69E-28
THYM	IUPHAR	RPL37A	PSMB1	0.805280949	5.14E-29
THYM	IUPHAR	RPL37A	NT5C	0.812607548	6.50E-30
THYM	IUPHAR	RPL37A	MVD	0.813878647	4.50E-30
THYM	IUPHAR	RPL37A	IMPDH2	0.831367419	2.10E-32
THYM	IUPHAR	RPL37A	SIRT6	0.855449098	4.33E-36
THYM	IUPHAR	RPL37A	SLC27A5	0.896950428	2.37E-44
THYM	TF	RPL37A	ZNF524	0.800520897	1.88E-28
THYM	TF	RPL37A	ZNF32	0.812228052	7.25E-30
THYM	TF	RPL37A	THAP7	0.817614352	1.50E-30
THYM	TF	RPL37A	REXO4	0.828536141	5.23E-32
THYM	TF	RPL37A	MBD3	0.830442533	2.84E-32
THYM	TF	RPL37A	ZNF428	0.835350118	5.69E-33
THYM	TF	RPL37A	THAP3	0.845310821	1.84E-34
THYM	TF	RPL37A	ZNF787	0.849196707	4.52E-35
THYM	TF	RPL37A	ZNF581	0.865370479	8.27E-38
THYM	TSG	RPL37A	GABARAP	0.802474819	1.11E-28
THYM	TSG	RPL37A	PARK7	0.810482245	1.20E-29
THYM	TSG	RPL37A	NPRL2	0.822331781	3.62E-31
THYM	TSG	RPL37A	GLTSCR2	0.851392378	2.01E-35
THYM	TSG	RPL37A	SIRT6	0.855449098	4.33E-36
THYM	TSG	RPL37A	GADD45GIP1	0.856963934	2.41E-36
THYM	TSG	RPL37A	BRMS1	0.864977485	9.73E-38
THYM	TSG	RPL37A	TSSC4	0.881824669	5.51E-41
THYM	TSG	RPL37A	GNB2L1	0.889610112	1.17E-42
UCS	Cell metabolism gene	RPL37A	MMAB	0.800682485	1.80E-28
UCS	Cell metabolism gene	RPL37A	SMPD2	0.800913491	1.69E-28
UCS	Cell metabolism gene	RPL37A	GUK1	0.804636286	6.14E-29
UCS	Cell metabolism gene	RPL37A	DPM3	0.804721854	5.99E-29
UCS	Cell metabolism gene	RPL37A	PSMB1	0.805280949	5.14E-29
UCS	Cell metabolism gene	RPL37A	GMPPA	0.807644081	2.66E-29
UCS	Cell metabolism gene	RPL37A	MTX1	0.808325252	2.20E-29
UCS	Cell metabolism gene	RPL37A	POLD2	0.808341522	2.19E-29
UCS	Cell metabolism gene	RPL37A	PMPCA	0.80982706	1.44E-29
UCS	Cell metabolism gene	RPL37A	POLR2J	0.810432974	1.21E-29
UCS	Cell metabolism gene	RPL37A	NT5C	0.812607548	6.50E-30
UCS	Cell metabolism gene	RPL37A	TIMM10	0.812927264	5.93E-30
UCS	Cell metabolism gene	RPL37A	MVD	0.813878647	4.50E-30
UCS	Cell metabolism gene	RPL37A	TOMM7	0.815722917	2.63E-30
UCS	Cell metabolism gene	RPL37A	HMBS	0.818537639	1.14E-30
UCS	Cell metabolism gene	RPL37A	PSMD13	0.819367202	8.90E-31
UCS	Cell metabolism gene	RPL37A	TOMM22	0.82074993	5.86E-31
UCS	Cell metabolism gene	RPL37A	SNRPD3	0.82077846	5.81E-31
UCS	Cell metabolism gene	RPL37A	PSMC5	0.822669152	3.27E-31
UCS	Cell metabolism gene	RPL37A	LCMT1	0.824765479	1.71E-31
UCS	Cell metabolism gene	RPL37A	EXOSC5	0.824993241	1.59E-31
UCS	Cell metabolism gene	RPL37A	LSM2	0.826681705	9.40E-32
UCS	Cell metabolism gene	RPL37A	TALDO1	0.82820852	5.80E-32
UCS	Cell metabolism gene	RPL37A	GFER	0.828936749	4.60E-32
UCS	Cell metabolism gene	RPL37A	IMPDH2	0.831367419	2.10E-32
UCS	Cell metabolism gene	RPL37A	APRT	0.834432754	7.71E-33
UCS	Cell metabolism gene	RPL37A	PSMC3	0.842349976	5.23E-34
UCS	Cell metabolism gene	RPL37A	POLR2F	0.842502087	4.96E-34
UCS	Cell metabolism gene	RPL37A	ITPA	0.843136261	3.97E-34
UCS	Cell metabolism gene	RPL37A	TIMM50	0.843448489	3.56E-34
UCS	Cell metabolism gene	RPL37A	PSMB3	0.844292989	2.64E-34
UCS	Cell metabolism gene	RPL37A	POLR2H	0.845164397	1.94E-34
UCS	Cell metabolism gene	RPL37A	ACOT8	0.845713646	1.59E-34
UCS	Cell metabolism gene	RPL37A	POLR2I	0.848068838	6.82E-35
UCS	Cell metabolism gene	RPL37A	EXOSC4	0.849517246	4.01E-35
UCS	Cell metabolism gene	RPL37A	PSMB7	0.859403551	9.27E-37
UCS	Cell metabolism gene	RPL37A	DPM2	0.865854029	6.76E-38
UCS	Cell metabolism gene	RPL37A	PGLS	0.870808604	8.24E-39
UCS	Cell metabolism gene	RPL37A	TIMM13	0.883179805	2.88E-41
UCS	Cell metabolism gene	RPL37A	TIMM8B	0.889953709	9.83E-43
UCS	Cell metabolism gene	RPL37A	SSR2	0.890629125	6.94E-43
UCS	Cell metabolism gene	RPL37A	SLC27A5	0.896950428	2.37E-44
UCS	Cell metabolism gene	RPL37A	SNRPD2	0.897385856	1.86E-44
UCS	Cell metabolism gene	RPL37A	PFDN5	0.909532562	1.40E-47
UCS	Cell metabolism gene	RPL37A	FAU	0.92780254	3.22E-53
UCS	CGC	RPL37A	TFPT	0.817904382	1.38E-30
UCS	CGC	RPL37A	SDHAF2	0.830937397	2.42E-32
UCS	CGC	RPL37A	RBM10	0.831676607	1.90E-32
UCS	Epifactor	RPL37A	INO80E	0.801894436	1.30E-28
UCS	Epifactor	RPL37A	DMAP1	0.80617422	4.01E-29
UCS	Epifactor	RPL37A	PPP4C	0.806238946	3.94E-29
UCS	Epifactor	RPL37A	RUVBL2	0.807206709	3.01E-29
UCS	Epifactor	RPL37A	TFPT	0.817904382	1.38E-30
UCS	Epifactor	RPL37A	RRP8	0.82013446	7.06E-31
UCS	Epifactor	RPL37A	EXOSC5	0.824993241	1.59E-31
UCS	Epifactor	RPL37A	C17orf49	0.826983778	8.54E-32
UCS	Epifactor	RPL37A	NOC2L	0.829000812	4.51E-32
UCS	Epifactor	RPL37A	MBD3	0.830442533	2.84E-32
UCS	Epifactor	RPL37A	ZNHIT1	0.83390354	9.18E-33
UCS	Epifactor	RPL37A	EXOSC4	0.849517246	4.01E-35
UCS	Epifactor	RPL37A	PRPF31	0.849650107	3.82E-35
UCS	Epifactor	RPL37A	SIRT6	0.855449098	4.33E-36
UCS	Epifactor	RPL37A	TAF10	0.862075811	3.18E-37
UCS	Epifactor	RPL37A	BRMS1	0.864977485	9.73E-38
UCS	Epifactor	RPL37A	FBL	0.917128092	9.16E-50
UCS	IUPHAR	RPL37A	SMPD2	0.800913491	1.69E-28
UCS	IUPHAR	RPL37A	PSMB1	0.805280949	5.14E-29
UCS	IUPHAR	RPL37A	NT5C	0.812607548	6.50E-30
UCS	IUPHAR	RPL37A	MVD	0.813878647	4.50E-30
UCS	IUPHAR	RPL37A	IMPDH2	0.831367419	2.10E-32
UCS	IUPHAR	RPL37A	SIRT6	0.855449098	4.33E-36
UCS	IUPHAR	RPL37A	SLC27A5	0.896950428	2.37E-44
UCS	TF	RPL37A	ZNF524	0.800520897	1.88E-28
UCS	TF	RPL37A	ZNF32	0.812228052	7.25E-30
UCS	TF	RPL37A	THAP7	0.817614352	1.50E-30
UCS	TF	RPL37A	REXO4	0.828536141	5.23E-32
UCS	TF	RPL37A	MBD3	0.830442533	2.84E-32
UCS	TF	RPL37A	ZNF428	0.835350118	5.69E-33
UCS	TF	RPL37A	THAP3	0.845310821	1.84E-34
UCS	TF	RPL37A	ZNF787	0.849196707	4.52E-35
UCS	TF	RPL37A	ZNF581	0.865370479	8.27E-38
UCS	TSG	RPL37A	GABARAP	0.802474819	1.11E-28
UCS	TSG	RPL37A	PARK7	0.810482245	1.20E-29
UCS	TSG	RPL37A	NPRL2	0.822331781	3.62E-31
UCS	TSG	RPL37A	GLTSCR2	0.851392378	2.01E-35
UCS	TSG	RPL37A	SIRT6	0.855449098	4.33E-36
UCS	TSG	RPL37A	GADD45GIP1	0.856963934	2.41E-36
UCS	TSG	RPL37A	BRMS1	0.864977485	9.73E-38
UCS	TSG	RPL37A	TSSC4	0.881824669	5.51E-41
UCS	TSG	RPL37A	GNB2L1	0.889610112	1.17E-42
UVM	Cell metabolism gene	RPL37A	IMPDH2	0.812404988	5.88E-20
UVM	Cell metabolism gene	RPL37A	SSR2	0.82217181	8.91E-21
UVM	Cell metabolism gene	RPL37A	FAU	0.889409121	3.06E-28
UVM	Epifactor	RPL37A	TRIM28	0.810805482	7.93E-20
UVM	Epifactor	RPL37A	FBL	0.900694268	5.73E-30
UVM	IUPHAR	RPL37A	TRIM28	0.810805482	7.93E-20
UVM	IUPHAR	RPL37A	IMPDH2	0.812404988	5.88E-20
UVM	Kinase	RPL37A	TRIM28	0.810805482	7.93E-20
UVM	TF	RPL37A	ZNF581	0.841373436	1.52E-22
UVM	TF	RPL37A	REXO4	0.844553133	7.36E-23
UVM	TSG	RPL37A	GLTSCR2	0.833085699	9.39E-22
UVM	TSG	RPL37A	GNB2L1	0.854591058	6.66E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL37A	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL37A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL37A	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL37A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL37A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL37A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL37A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL37A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL37A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL37A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL37A	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL37A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL37A	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL37A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL37A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL37A	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL37A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL37A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL37A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL37A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL37A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL37A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL37A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL37A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL37A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL37A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL37A	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL37A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL37A

PSTPIP1, LRIF1, CUL3, CUL1, COPS5, CAND1, APP, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18, RPL19, RPL21, RPL22, RPL23, RPL24, RPL27A, RPL30, RPL31, RPL5, RPL6, RPS11, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS23, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS6, RPS7, RPS8, RPSA, RPL23A, RPL4, RPL7A, RPL7, RPL18A, RPS19, RPS5, RPL9, RPS24, RPS20, RPS12, RPL17, RPS21, RPS27A, SLC25A5, NOP56, GNL3, MYBBP1A, ILF3, DHX9, EIF4A3, DDX21, U2AF2, U2AF1, NOP58, NHP2L1, EIF6, TUFM, NAP1L1, RPS27L, PRPF8, RPLP0P6, RPS10P5, RBM25, TPR, RPL10L, M6PR, PRPF40A, DEK, GNB2L1, HIST1H2AD, NFIA, ESR1, UBL4A, NKX3-1, PAN2, CTPS2, IFNGR2, BUB3, TP53, TUBGCP3, MAGEA6, RPL8, NIFK, NPM1, AHCYL1, EIF2S2, EIF3I, IGF2BP1, IGF2BP3, PABPC1, RPL10, RPL13A, RPL26, RPL27, RPL3, RPL32, RPL34, RPL35, RPL36, RPL37, RPL38, RPL39, RPL3L, RPLP0, RPLP1, RPLP2, RPS10, RPS15, LOC101929876, RPS9, RRS1, SERBP1, RPS18, gag, HIST1H3E, KIF11, CDK18, PRKCD, SMC3, EXOSC4, Eif3e, Lgals3bp, Mta1, Brwd3, MCM2, EID1, TUBA8, FAM199X, ZC3HAV1, RPL26L1, CDK12, NOC3L, DDX24, NCL, KIAA0020, DDX31, DDX27, ZC3H10, BRIX1, GNL2, SART3, RPL36AL, ZNF2, RRP8, FTSJ3, NOP2, BUD13, EBNA1BP2, CENPN, NSA2, CNBP, SREK1, GLYR1, PPAN-P2RY11, RBM34, PAPD5, RPF2, STAU1, REXO4, GLTSCR2, ZFP62, WHSC1, HIST1H1E, RBM28, PPAN, TAF1C, MYEF2, MPHOSPH10, ZNF512, TAF1A, DKC1, IMP4, CCDC137, DHX30, KNOP1, NIP7, RPL7L1, GAR1, LYAR, GTPBP4, WDR46, GPATCH4, RPF1, STAU2, FYTTD1, UTP23, H2AFY2, CEBPZ, RPL29, TTF1, UTP3, ZNF22, DDX10, SURF6, RSL24D1, DDX56, HIST2H2AB, RBBP5, PAK1IP1, MDM2, PTPN6, RNGTT, CYLD, TRIM25, BRCA1, CFTR, FBXO7, WDR5, AAR2, LARP7, MEPCE, AGR2, RECQL4, REST, Prkaa1, Prkab1, GRWD1, RC3H1, RC3H2, PHB, NR2C2, PPP1CC, KRAS, VRK1, AKT3, MICB, NOD2, SNRNP70, ITFG1, BIRC3, NFX1, WWP2, PLEKHA4, HCVgp1, ZC3H18, GRB7, MAP3K14, RAB5A, M, nsp13, nsp4, nsp6, ORF3a, ORF7a, CHMP4C, KIF14, KIF20A, PRC1, LRRC59, INS, NDN, E5b, Apc2, RBM39, FBP1, DNAJC1, DNAJC2, SETD4, CXXC1, KANSL2, YEATS2, MCRS1, ASH2L, SETD8, ZZZ3, KMT2B, MBIP, KANSL3, KANSL1, RERE, SETD1A, POU2F1, PARK2, UFL1, DDRGK1, ATG7, USP15, FZR1, MAP4K3, MINK1, BLK, PRKRA, SRSF5, SRSF6, PNMAL1, HIST1H1B, LLPH, C7orf50, ZNF48, CENPV, HIST1H1C, CBX6, KAL1, SART1, PURG, PRDM15, SRPK3, H1FOO, NPM3, ABT1, FGFBP1, ADARB1, ZNF770, RPL28, NEIL1, MAGEB2, HIST1H1A, ZNF346, HIST1H2AG, LIN28A, NKRF, SPRTN, BTF3, FBXW7, NLRP7, RCHY1, SQSTM1, N, SIRT6, NHLH1, EN1, MYB, KLF15, RB1CC1, KLF16, KLF5, KLF8,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL37A	KIRP	chr2	217364692	217364692	T	A	Silent	p.A51A	6
RPL37A	ESCA	chr2	217364062	217364062	A	T	Missense_Mutation	p.M25L	3
RPL37A	STAD	chr2	217366124	217366124	G	A	Silent	p.Q92Q	2
RPL37A	ESCA	chr2	217364062	217364062	A	T	Missense_Mutation		2
RPL37A	UCEC	chr2	217364099	217364099	A	C	Missense_Mutation	p.Y37S	2
RPL37A	KIRP	chr2	217364692	217364692	T	A	Silent		2
RPL37A	LGG	chr2	217364056	217364056	C	T	Missense_Mutation	p.R23W	2
RPL37A	STAD	chr2	217364716	217364716	C	A	Silent	p.S59S	2
RPL37A	THCA	chr2	217366063	217366063	G	A	Splice_Site	.	1
RPL37A	HNSC	chr2	217364725	217364725	G	C	Missense_Mutation	p.K62N	1
RPL37A	KIRP	chr2	217364702	217364709	TGGCACTG	-	Frame_Shift_Del	p.54_57del	1
RPL37A	LGG	chr2	217364056	217364056	C	T	Missense_Mutation		1
RPL37A	LIHC	chr2	217366116	217366116	A	-	Frame_Shift_Del	p.K90fs	1
RPL37A	BLCA	chr2	217364038	217364038	C	A	Missense_Mutation		1
RPL37A	OV	chr2	217364707	217364707	C	T	Silent	p.H56	1
RPL37A	BLCA	chr2	217363511	217363511	C	G	Missense_Mutation		1

Copy number variation (CNV) of RPL37A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL37A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102946	N/A	AA526704	ALG5	chr13	37551927	-	RPL37A	chr2	217366190	-
102946	N/A	AK001254	CCDC88A	chr2	55522937	-	RPL37A	chr2	217366095	+
102946	N/A	BI491370	CTNND2	chr5	11374923	+	RPL37A	chr2	217366190	-
102946	N/A	BG222076	EFCAB6-AS1	chr22	43920603	+	RPL37A	chr2	217366190	-
102946	N/A	AA559192	FAM120B	chr6	170702235	-	RPL37A	chr2	217366190	-
102946	N/A	EC560505	FAM228B	chr2	24384700	+	RPL37A	chr2	217364731	+
102946	LIHC	TCGA-DD-A3A5-01A	IGFBP2	chr2	217498688	+	RPL37A	chr2	217385437	+
102946	N/A	EC560978	IL1RAPL2	chrX	104061955	-	RPL37A	chr2	217364068	+
102946	N/A	AA507779	MSL2	chr3	135884050	-	RPL37A	chr2	217366190	-
102946	N/A	BI496565	NKAIN3	chr8	63558465	-	RPL37A	chr2	217366180	-
102946	N/A	AA533465	PCP4	chr21	41275799	-	RPL37A	chr2	217366190	-
102946	N/A	BG478185	PRPF8	chr17	1581811	-	RPL37A	chr2	217363988	+
102946	STAD	TCGA-D7-8574	RBM33	chr7	155437613	+	RPL37A	chr2	217363992	+
102946	STAD	TCGA-D7-8574-01A	RBM33	chr7	155437613	+	RPL37A	chr2	217363993	+
102946	Non-Cancer	5381N	RCC1	chr1	28834672	+	RPL37A	chr2	217363992	+
102946	N/A	BG223413	REPS2	chrX	17135284	-	RPL37A	chr2	217364672	+
97972	N/A	AA744421	RPL37A	chr2	217366190	+	ALK	chr2	29531213	-
86753	N/A	BG031433	RPL37A	chr2	217366190	+	ATG10	chr5	81357664	-
94400	N/A	AW246883	RPL37A	chr2	217363991	-	CBX6	chr22	39262273	+
76716	N/A	BU634160	RPL37A	chr2	217366987	-	CHPT1	chr12	102140628	+
101234	N/A	BF217525	RPL37A	chr2	217366190	+	COMMD10	chr5	115638994	-
99198	N/A	AW020076	RPL37A	chr2	217366190	+	CSMD1	chr8	3646980	-
91741	N/A	AW020311	RPL37A	chr2	217366190	+	CTNND2	chr5	11374923	-
102756	SKCM	TCGA-GN-A262-06A	RPL37A	chr2	217366186	-	DDX27	chr20	47849303	+
94953	N/A	DR759675	RPL37A	chr2	217364051	+	DHX57	chr2	39046202	-
76716	N/A	AA531074	RPL37A	chr2	217366190	+	DOCK4	chr7	111504293	+
76716	N/A	CF124049	RPL37A	chr2	217366190	+	EBF4	chr20	2696867	+
89665	N/A	AA523771	RPL37A	chr2	217366190	+	EFCAB6-AS1	chr22	43920603	-
95997	STAD	TCGA-BR-A4QI-01A	RPL37A	chr2	217364754	+	ERBB4	chr2	212652884	-
99835	COAD	TCGA-AA-3531-01A	RPL37A	chr2	217364031	+	ETV5	chr3	185826703	-
102854	N/A	BE045088	RPL37A	chr2	217366190	+	FAM120B	chr6	170702235	+
89647	N/A	GW492939	RPL37A	chr2	217366190	+	GOLGA4	chr3	37348926	+
83969	N/A	CD365929	RPL37A	chr2	217366069	-	HCK	chr20	30671812	-
80325	GBM	TCGA-76-4931-01A	RPL37A	chr2	217364754	+	IGFBP2	chr2	217525280	+
92165	N/A	DN912253	RPL37A	chr2	217366190	+	INPP5A	chr10	134460635	-
85790	N/A	BI496566	RPL37A	chr2	217366190	+	KCNB2	chr8	73733864	+
76716	N/A	AA631668	RPL37A	chr2	217364685	-	KLHL12	chr1	202887306	+
97209	N/A	AW023530	RPL37A	chr2	217366190	+	LARP1B	chr4	128983772	-
102892	N/A	AI525486	RPL37A	chr2	217366190	+	MAP3K2	chr2	128064922	+
76716	N/A	CF124171	RPL37A	chr2	217366190	+	MKS1	chr17	56282817	+
99886	N/A	BI857685	RPL37A	chr2	217366190	+	MRPL48	chr11	73545895	-
81407	N/A	BU954401	RPL37A	chr2	217366187	+	MYL6	chr12	56553913	+
90848	N/A	CF123757	RPL37A	chr2	217366183	+	NARS2	chr11	78179084	+
98948	PRAD	TCGA-KC-A4BL-01A	RPL37A	chr2	217366186	-	NDUFV1	chr11	67375697	+
76716	N/A	BI862578	RPL37A	chr2	217366190	+	NEB	chr2	152580288	-
81580	COAD	TCGA-AA-A01R-01A	RPL37A	chr2	217366091	+	NRXN2	chr11	64390518	-
98498	STAD	TCGA-D7-8576-01A	RPL37A	chr2	217364754	+	PIK3C2G	chr12	18443789	+
76716	N/A	AA535584	RPL37A	chr2	217366190	+	POM121L7	chr22	21468878	-
102946	N/A	EC541718	RPL37A	chr2	217366069	-	RPL37A	chr2	217366099	+
83858	N/A	EC464784	RPL37A	chr2	217363601	+	RPS24	chr10	79796952	+
100926	N/A	CD240086	RPL37A	chr2	217366190	+	RPTOR	chr17	78770946	-
87312	N/A	CB048993	RPL37A	chr2	217366190	+	SBF2	chr11	9814506	-
80397	N/A	CD049225	RPL37A	chr2	217366184	+	SENP3-EIF4A1	chr17	7477605	+
76716	STAD	TCGA-CD-8535-01A	RPL37A	chr2	217364754	+	SMARCAL1	chr2	217332667	+
76716	N/A	BF526865	RPL37A	chr2	217366190	+	SRL	chr16	4225581	+
98557	N/A	BI857930	RPL37A	chr2	217366190	+	SYTL2	chr11	85498758	-
102226	N/A	BI861558	RPL37A	chr2	217366190	+	TDRD12	chr19	33220139	-
76716	N/A	CF123466	RPL37A	chr2	217366190	+	TEX33	chr22	37390690	-
76716	N/A	CD240079	RPL37A	chr2	217366190	+	THAP9	chr4	83825239	-
98868	N/A	CD240163	RPL37A	chr2	217366190	+	WDPCP	chr2	63589413	-
100718	N/A	T12393	RPL37A	chr2	217364710	+	ZBTB7C	chr18	45755448	-
76716	N/A	AA469386	RPL37A	chr2	217366190	+	ZNF675	chr19	23715550	-
102946	N/A	CB048992	SBF2-AS1	chr11	9814506	+	RPL37A	chr2	217366190	-
102946	STAD	TCGA-CD-8527-01A	SLC35A2	chrX	48763669	-	RPL37A	chr2	217363993	+
102946	N/A	BG223182	STRN3	chr14	31445042	-	RPL37A	chr2	217366190	-
102946	Non-Cancer	13N	TRPM4	chr19	49669472	+	RPL37A	chr2	217363992	+
102946	N/A	AA876568	ULK4	chr3	41883667	-	RPL37A	chr2	217366190	-
102946	STAD	TCGA-BR-A4PE-01A	XRCC5	chr2	216974180	+	RPL37A	chr2	217364672	+
102946	STAD	TCGA-HU-A4G2	XRCC5	chr2	216974180	+	RPL37A	chr2	217363992	+
102948	PRAD	TCGA-ZG-A9N3	ZNF789	chr7	99077410	+	RPL37A	chr2	217393993	+
102948	PRAD	TCGA-ZG-A9N3-01A	ZNF789	chr7	99077410	+	RPL37A	chr2	217384055	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BLCA	RPL37A	0.0396459165790812	1
COAD	RPL37A	0.0484737018083081	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL37A	0.0366523214946794	1
BLCA	RPL37A	0.0216827213133651	0.72

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0032460	Polycystic Ovary Syndrome	1	CTD_human
C1136382	Sclerocystic Ovaries	1	CTD_human