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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: METTL16 (NCBI Gene ID:79066)

Gene Summary

Gene Summary

Gene Information	Gene Name: METTL16
	Gene ID: 79066
	Gene Symbol	METTL16
	Gene ID	79066
	Gene Name	methyltransferase like 16
	Synonyms	METT10D
	Cytomap	17p13.3
	Type of Gene	protein-coding
	Description	RNA N6-adenosine-methyltransferase METTL16N6-adenosine-methyltransferase METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferaseU6 snRNA methyltransferasemethyltransferase 10 domain containingmethyltransferase 10 domain-containing proteinm
	Modification date	20200320
	UniProtAcc	Q86W50

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	METTL16	GO:0006556	S-adenosylmethionine biosynthetic process	28525753\|30197297
Hgene	METTL16	GO:0010608	posttranscriptional regulation of gene expression	28525753
Hgene	METTL16	GO:0048024	regulation of mRNA splicing, via spliceosome	28525753
Hgene	METTL16	GO:0080009	mRNA methylation	30197297\|30197299
Hgene	METTL16	GO:0120049	snRNA (adenine-N6)-methylation	28525753\|29051200
Hgene	METTL16	GO:1905869	negative regulation of 3'-UTR-mediated mRNA stabilization	28525753

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
METTL16	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'METTL16[title] AND translation [title] AND human.'

Gene	Title	PMID
METTL16	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000263092	2341402	2341492	In-frame
ENST00000263092	2371054	2371170	Frame-shift
ENST00000263092	2376817	2376958	In-frame
ENST00000263092	2405497	2405625	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000263092	2341402	2341492	5728	927	1016	562	266	296
ENST00000263092	2376817	2376958	5728	457	597	562	109	156
ENST00000263092	2405497	2405625	5728	129	256	562	0	42

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q86W50	0	42	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Q86W50	109	156	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Q86W50	266	296	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Q86W50	266	296	289	400	Region	Note=VCR 1;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28525753;Dbxref=PMID:28525753
Q86W50	109	156	110	110	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PDB:2H00,ECO:0000269\|Ref.13
Q86W50	109	156	133	133	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PDB:2H00,ECO:0000269\|Ref.13
Q86W50	266	296	225	562	Alternative sequence	ID=VSP_029341;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q86W50	0	42	39	39	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q86W50	0	42	5	7	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	0	42	12	15	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	0	42	20	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	0	42	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	105	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	112	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	116	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	128	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	136	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	152	154	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	109	156	155	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	266	296	268	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91
Q86W50	266	296	280	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6B91

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with METTL16 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	METTL16	RBM15B	-2.89224914085525	0.000102996826171875
KIRP	METTL16	RBM15B	-4.15875719217488	0.000280400272458792
KIRC	METTL16	RBM15	-1.35007713201106	0.000600141235926365
COAD	METTL16	KIAA1429	-3.39420981646075	0.000664144754409791
LUAD	METTL16	METTL14	-1.43596594596523	0.00121089428940613
HNSC	METTL16	RBM15B	-2.90773760599283	0.00186235073124408
PRAD	METTL16	RBM15	-1.09327807917714	0.00277499505363991
CHOL	METTL16	RBM15B	-2.36781718450114	0.0078125
LUAD	METTL16	WTAP	-1.78616226090853	0.00791615044666943
LUAD	METTL16	RBM15	-1.24579793729144	0.0103856608841715
KIRC	METTL16	WTAP	-2.70273660495067	0.0143053039058135
BLCA	METTL16	WTAP	-2.90881954846739	0.0159721374511719
STAD	METTL16	KIAA1429	-1.61567103280556	0.020511694252491
ESCA	METTL16	RBM15B	-2.20401464424729	0.0244140625
LUAD	METTL16	MAT2A	1.42883184393255	0.0278902380223951
READ	METTL16	MAT2A	-4.20640628561165	0.03125
BRCA	METTL16	RBM15B	-1.21088084774422	0.0367624289903515
CHOL	METTL16	KIAA1429	-2.83229200442768	0.0390625
CHOL	METTL16	METTL3	-3.31943495691848	0.0390625
UCEC	METTL16	WTAP	-3.78629147221377	0.046875
LUAD	METTL16	METTL8	-1.35943731385146	1.10446534121172e-08
COAD	METTL16	METTL3	-3.54288918740857	2.08616256713867e-06
THCA	METTL16	MAT2A	-2.23545517548056	2.28018015752425e-08
THCA	METTL16	KIAA1429	1.4688007829704	2.5764473552472e-05
THCA	METTL16	METTL14	-2.3091931665824	3.03433720687169e-07
LIHC	METTL16	METTL3	-1.43381447667708	3.17814170396599e-08
PRAD	METTL16	METTL3	2.27777667743557	5.10126106041513e-07
HNSC	METTL16	RBM15	1.40615182569303	5.61373060463667e-05
THCA	METTL16	WTAP	-2.89392443867004	5.83719995580266e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with METTL16

MEPCE, APP, YARS, FAM50A, HCCS, NHP2L1, TCEA1, NTRK1, METTL16, KPNA6, SLC39A9, LARP7, RNU6-1, KIAA1429, PTEN, SNRNP70, LMBR1L, ORF7b, KIF14, LDLR, BCAR1, ORF4a, BRD4, WDR5, GPRC5D, GYPA, HYPM,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
METTL16	LGG	chr17	2324130	2324130	G	A	Silent	p.S319S	3
METTL16	UCEC	chr17	2324179	2324179	C	A	Missense_Mutation	p.R303I	2
METTL16	LGG	chr17	2371168	2371168	C	T	Missense_Mutation	p.V158M	2
METTL16	UCEC	chr17	2324182	2324182	C	T	Missense_Mutation	p.R302Q	2
METTL16	LIHC	chr17	2371076	2371076	A	-	Frame_Shift_Del	p.F188fs	2
METTL16	UCEC	chr17	2344825	2344825	A	G	Missense_Mutation	p.C253R	2
METTL16	CESC	chr17	2381091	2381091	C	G	Missense_Mutation		2
METTL16	LUAD	chr17	2381013	2381013	C	T	Missense_Mutation	p.D99N	2
METTL16	SKCM	chr17	2323568	2323568	G	A	Missense_Mutation	p.P462L	2
METTL16	LGG	chr17	2324130	2324130	G	A	Silent		2
METTL16	KIRC	chr17	2323872	2323872	G	A	Missense_Mutation	p.P361S	2
METTL16	SKCM	chr17	2323843	2323843	G	A	Silent	p.F370F	2
METTL16	SKCM	chr17	2381162	2381162	G	A	Missense_Mutation	p.P49L	2
METTL16	SKCM	chr17	2405514	2405514	G	A	Silent	p.L38L	2
METTL16	KIRP	chr17	2323643	2323643	C	A	Missense_Mutation	p.R437L	2
METTL16	SKCM	chr17	2381097	2381097	G	A	Missense_Mutation	p.P71S	2
METTL16	KIRP	chr17	2344810	2344810	G	T	Missense_Mutation		2
METTL16	BLCA	chr17	2341488	2341488	G	C	Missense_Mutation		1
METTL16	LIHC	chr17	2380980	2380980	C	T	Missense_Mutation	p.G110S	1
METTL16	GBM	chr17	2381079	2381079	G	T	Missense_Mutation		1
METTL16	PAAD	chr17	2324089	2324089	G	T	Nonsense_Mutation	p.S333X	1
METTL16	SKCM	chr17	2323815	2323815	G	T	Missense_Mutation	p.H380N	1
METTL16	BLCA	chr17	2324067	2324067	G	T	Silent		1
METTL16	HNSC	chr17	2323366	2323366	G	A	Silent		1
METTL16	READ	chr17	2323838	2323838	G	A	Missense_Mutation	p.T372M	1
METTL16	SKCM	chr17	2323675	2323675	G	A	Silent	p.P426P	1
METTL16	BLCA	chr17	2341488	2341488	G	C	Missense_Mutation	p.P268R	1
METTL16	LIHC	chr17	2381077	2381077	G	-	Frame_Shift_Del	p.P77fs	1
METTL16	HNSC	chr17	2323740	2323740	C	T	Missense_Mutation		1
METTL16	SARC	chr17	2323314	2323314	G	T	Missense_Mutation		1
METTL16	LGG	chr17	2323752	2323752	C	T	Missense_Mutation	p.D401N	1
METTL16	SKCM	chr17	2323266	2323266	A	T	Nonstop_Mutation	p.*563K	1
METTL16	LIHC	chr17	2405536	2405536	A	-	Frame_Shift_Del	p.F30fs	1
METTL16	HNSC	chr17	2323740	2323740	C	T	Missense_Mutation	p.A405T	1
METTL16	SARC	chr17	2310279	2310279	G	A	RNA	NULL	1
METTL16	LGG	chr17	2323636	2323636	G	A	Silent	p.G439G	1
METTL16	SKCM	chr17	2323707	2323707	A	G	Missense_Mutation	p.S416P	1
METTL16	CESC	chr17	2381091	2381091	C	G	Missense_Mutation	p.E73Q	1
METTL16	HNSC	chr17	2323366	2323366	G	A	Silent	p.A529A	1
METTL16	LGG	chr17	2323299	2323299	G	A	Missense_Mutation	p.R552C	1
METTL16	SKCM	chr17	2381128	2381128	T	A	Silent	p.L60L	1
METTL16	STAD	chr17	2324091	2324091	G	C	Silent	p.R332R	1
METTL16	COAD	chr17	2323517	2323517	C	T	Missense_Mutation	p.S479N	1
METTL16	LUAD	chr17	2323656	2323656	C	A	Missense_Mutation	p.G433W	1
METTL16	HNSC	chr17	2323539	2323539	C	A	Nonsense_Mutation	p.G472*	1
METTL16	SKCM	chr17	2323266	2323266	A	T	Missense_Mutation	p.X563K	1
METTL16	SKCM	chr17	2323331	2323331	C	T	Missense_Mutation	p.R541K	1
METTL16	STAD	chr17	2323660	2323660	G	-	Frame_Shift_Del	p.C432fs	1
METTL16	COAD	chr17	2324158	2324158	T	A	Missense_Mutation	p.K310I	1
METTL16	LUAD	chr17	2367611	2367611	G	C	Missense_Mutation	p.P207A	1
METTL16	LGG	chr17	2371168	2371168	C	T	Missense_Mutation		1
METTL16	STAD	chr17	2323552	2323552	C	T	Silent	p.R467R	1
METTL16	THYM	chr17	2323680	2323680	C	T	Missense_Mutation		1
METTL16	COAD	chr17	2341478	2341478	C	T	Silent	p.T271T	1
METTL16	LUSC	chr17	2381044	2381044	C	A	Missense_Mutation	p.W88C	1
METTL16	KIRC	chr17	2323880	2323880	T	G	Missense_Mutation	p.K358T	1
METTL16	LGG	chr17	2323299	2323299	G	A	Missense_Mutation		1
METTL16	STAD	chr17	2324151	2324151	T	G	Silent	p.I312I	1
METTL16	THYM	chr17	2323353	2323353	G	A	Missense_Mutation		1
METTL16	DLBC	chr17	2371109	2371109	G	C	Missense_Mutation	p.I177M	1
METTL16	LUSC	chr17	2405605	2405605	C	T	Missense_Mutation	p.M7I	1
METTL16	KIRP	chr17	2405596	2405596	T	G	Missense_Mutation	p.R10S	1
METTL16	LGG	chr17	2323636	2323636	G	A	Silent		1
METTL16	THYM	chr17	2323353	2323353	G	A	Missense_Mutation	p.H534Y	1
METTL16	LUSC	chr17	2323574	2323574	G	C	Missense_Mutation	p.P460R	1
METTL16	GBM	chr17	2376954	2376954	C	A	Silent		1
METTL16	LIHC	chr17	2323799	2323799	T	C	Missense_Mutation	p.K385R	1
METTL16	THYM	chr17	2323680	2323680	C	T	Missense_Mutation	p.G425S	1
METTL16	GBM	chr17	2324096	2324096	G	A	Silent		1
METTL16	OV	chr17	2323627	2323627	G	A	Silent	p.A442A	1
METTL16	SKCM	chr17	2381069	2381069	G	A	Missense_Mutation	p.P80L	1

Copy number variation (CNV) of METTL16
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across METTL16
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100143	SARC	TCGA-N1-A6IA	GPATCH8	chr17	42512432	-	METTL16	chr17	2381179	-
100143	SARC	TCGA-N1-A6IA-01A	GPATCH8	chr17	42512433	-	METTL16	chr17	2381179	-
100143	N/A	BC047770	H6PD	chr1	9295721	+	METTL16	chr17	2320444	-
100143	N/A	CV420659	MECP2	chrX	153355617	+	METTL16	chr17	2352115	-
53071	SARC	TCGA-DX-A3M1-01A	METTL16	chr17	2339968	-	CLEC10A	chr17	6982204	-
53071	HNSC	TCGA-F7-8298-01A	METTL16	chr17	2376818	-	DHX8	chr17	41566817	+
53071	LUSC	TCGA-98-8020	METTL16	chr17	2344784	-	FAM101B	chr17	293285	-
93209	SARC	TCGA-IE-A6BZ-01A	METTL16	chr17	2405498	-	FXR2	chr17	7507398	-
93209	SARC	TCGA-IE-A6BZ-01A	METTL16	chr17	2405498	-	FXR2	chr17	7509467	-
90830	BRCA	TCGA-A8-A08G-01A	METTL16	chr17	2367502	-	KDM6B	chr17	7749190	+
99622	N/A	FN119331	METTL16	chr17	2369649	-	LACTB2	chr8	71577421	-
100143	N/A	CV395950	METTL16	chr17	2385933	+	METTL16	chr17	2404906	-
95663	N/A	CB054915	METTL16	chr17	2319343	-	PPP6R2	chr22	50793679	-
100155	UCEC	TCGA-D1-A3DH	METTL16	chr17	2341402	-	RTN4RL1	chr17	1841102	-
100155	UCEC	TCGA-D1-A3DH-01A	METTL16	chr17	2341403	-	RTN4RL1	chr17	1841102	-
84133	BLCA	TCGA-DK-A1A6	METTL16	chr17	2415052	-	VPS53	chr17	463813	-
84133	BLCA	TCGA-DK-A1A6-01A	METTL16	chr17	2415053	-	VPS53	chr17	463813	-
100143	N/A	AA226015	PAFAH1B1	chr17	2562475	-	METTL16	chr17	2413300	-
100143	N/A	CB054900	PPP6R2	chr22	50793679	+	METTL16	chr17	2319343	+
100143	N/A	BG059139	WDR82	chr3	52289320	+	METTL16	chr17	2327643	+
100162	OV	TCGA-61-2111	YWHAE	chr17	1303340	-	METTL16	chr17	2405625	-
100162	OV	TCGA-61-2111-01A	YWHAE	chr17	1303341	-	METTL16	chr17	2405625	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source